| In this study , we found that protein phosphatase 2Cbeta ( PP2Cbeta ) , which functions in the nuclear factor kappaB ( NF kappaB ) pathway via dephosphorylation of TGF beta activated kinase , was ISGylated , and analysis by NF kappaB luciferase reporter assay revealed that PP2Cbeta activity was suppressed by co expression of ISG 15 , UBE1L , and UbcH 8 . ^^^ |