| Interacting proteins: Q15762 and P05107 |
Pubmed |
SVM Score :1.037945 |
| Further studies demonstrated that LFA 1 physically associates with DNAM 1 in NK cells and anti CD 3 mAb stimulated T cells , for which serine phosphorylation of DNAM 1 plays a critical role . 1.037945^^^ |
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| Interacting proteins: Q15762 and P05107 |
Pubmed |
SVM Score :0.61673765 |
| The TCR mediated signal also induces physical association of DNAM 1 with LFA 1 , for which the serine phosphorylation of DNAM 1 is also responsible . 0.61673765^^^ These results suggest that the serine phosphorylation of DNAM 1 primarily induces physical association of DNAM 1 with LFA 1 , which then takes DNAM 1 into lipid raft compartment . . 0.52540379^^^ |
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| Interacting proteins: Q15762 and P05107 |
Pubmed |
SVM Score :0.0 |
| The expression levels of adhesion molecules ( CD 2 , CD11a , CD 18 , DNAX accessory molecule 1 ) , CD 16 , and CD 57 for CD56dim NK cells in CB were significantly lower than those in PB , and approximately one third of CB CD56dim NK cells were capable of forming conjugates with K 562 cells , compared with PB CD56dim NK cells . ^^^ |
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| Interacting proteins: Q15762 and P05107 |
Pubmed |
SVM Score :0.0 |
| Upon antigen recognition by the T cell receptor , lymphocyte function associated antigen 1 ( LFA 1 ) physically associates with the leukocyte adhesion molecule CD 226 ( DNAM 1 ) and the protein tyrosine kinase Fyn . ^^^ |
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| Interacting proteins: Q15762 and P05107 |
Pubmed |
SVM Score :0.0 |
| Upon antigen recognition by the TCR , leukocyte function associated antigen 1 ( LFA 1 ) physically associates with the leukocyte adhesion molecule DNAM 1 ( CD 226 ) , for which the serine phosphorylation at residue 329 ( S 329 ) of DNAM 1 plays a critical role . ^^^ The TCR mediated signal also induces the formation of the immunological synapse ( IS ) , in which lipid raft associated molecules , including LFA 1 , DNAM 1 , protein kinase C , Fyn and others , are recruited , resulting in efficient signal transduction for T cell activation . ^^^ We also demonstrate that the association of DNAM 1 with lipid rafts was necessary for the tyrosine phosphorylation of DNAM 1 , which is essential for LFA 1 mediated co stimulatory signaling for naive T cell proliferation and differentiation . . ^^^ |
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| Interacting proteins: Q15762 and P05107 |
Pubmed |
SVM Score :0.0 |
| The LFA 1 associated molecule PTA 1 ( CD 226 ) on T cells forms a dynamic molecular complex with protein 4 . 1G and human discs large . ^^^ |
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| Interacting proteins: Q15762 and P05107 |
Pubmed |
SVM Score :0.0 |
| We investigated the expression of CD 226 and lymphocyte function associated antigen 1 ( LFA 1 ) ( CD11a ) during hemopoiesis . ^^^ We also studied the effect of CD 226 monoclonal antibody ( MoAb ) and LFA 1 MoAb on megakaryocyte with antibody cross liking technique . ^^^ CD 226 MoAb in combination with LFA 1 MoAb shifted the ploidy of generated megakaryocytes from adult derived CD 34 ( + ) cells to higher classes significantly although CD 226 and LFA 1 MoAb slightly increased the ploidy of the generated megakaryocytes individually . ^^^ CD 226 MoAb or LFA 1 MoAb or CD 226 MoAb plus LFA 1 MoAbs did not increase the ploidy of the generated megakaryocytes from fetus derived CD 34 ( + ) cells . ^^^ CONCLUSION : CD 226 molecules play an important role in maturation of the megakaryocytes in combination with LFA 1 . . ^^^ |
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| Interacting proteins: Q15762 and P05107 |
Pubmed |
SVM Score :0.0 |
| CD 226 synergizes with FcepsilonRI on mast cells , and its engagement augments degranulation through a pathway involving Fyn , linker of activation of T cells , phospholipase C gamma 2 , and CD 18 . ^^^ |
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