Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.63393527
ICAM 3 interacts with LFA 1 and regulates the LFA 1 / ICAM 1 cell adhesion pathway . 0.63393527^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :1.1649884
ICAM 3 appears to be unique among the ICAMs in utilizing residues on both faces of domain 1 for interaction with its ligand LFA 1 . . 1.1649884^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.63140711
ICAM 3 binds to LFA 1 on antigen presenting cells ( APC ) stabilizing the T cell APC interaction , facilitating signaling through the CD3 / TCR complex . 0.63140711^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.59911805
We observed that although ICAM 3 binds poorly to LFA 1 expressed on resting T cells , it specifically facilitates and increases LFA 1 mediated adhesion to the high affinity ligand of LFA 1 , ICAM 1 . 0.59911805^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.84119481
We report that 1 ) LFA 1 binds ICAM 3 as its primary ligand supporting homotypic adhesion , although the possibility of other ligands was also detected . 2 ) Mac 1 binding to an unidentified ligand supports homotypic adhesion with an efficiency comparable to LFA 1 at low shear rates of approximately 100 s 1 . 0.84119481^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.54957535
ICAM 3 interacts with LFA 1 , and is involved in the intercellular adhesion of leukocytes as well as in the mainenance of cell survival . 0.54957535^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.93479692
These findings suggest that the interaction of CD 50 with its natural ligand ( LFA 1 ) may result in T lymphocyte activation events , in which CD 50 could play a very active role after antigen triggering . . 0.93479692^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.91566014
Our findings suggest that the interaction of CD 50 with its natural ligand LFA 1 results in the induction of apoptosis in a significant fraction of resting PBMC . 0.91566014^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Thus , targeting LFA 1 alpha with mAb results in homotypic aggregation of T cell lines which is independent of ICAM 1 / LFA 1 interactions , but may involve other LFA 1 ligands such as ICAM 2 or ICAM 3 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Molecular cloning of ICAM 3 , a third ligand for LFA 1 , constitutively expressed on resting leukocytes . ^^^ Recent work has indicated that resting leukocytes express a third ligand , ICAM 3 , for LFA 1 ( refs 11 , 12 ) . ^^^ ICAM 3 is potentially the most important ligand for LFA 1 in the initiation of the immune response because the expression of ICAM 1 on resting leukocytes is low . ^^^ ICAM 3 is closely related to ICAM 1 , consists of five immunoglobulin domains , and binds LFA 1 through its two N terminal domains . . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Other leukointegrin ligands therefore probably exist , such as a glycoprotein of M ( r ) 124K that binds LFA 1 and has been designated ICAM 3 on the basis of this function . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
In assays of adhesion of resting lymphocytes to purified LFA 1 , ICAM 3 is by far the most functionally important ICAM , implying an important role for ICAM 3 in the generation of immune responses . . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Expression of ICAM R ( ICAM 3 ) , a novel counter receptor for LFA 1 , in rheumatoid and nonrheumatoid synovium . ^^^ To study the distribution of intercellular adhesion molecule receptor ( ICAM R , or ICAM 3 ) , a novel ligand for the leukointegrin lymphocyte function associated antigen 1 ( LFA 1 ) , in normal and rheumatoid synovial membranes and to compare this with the distribution of ICAM 1 , ICAM 2 , vascular cell adhesion molecule 1 ( VCAM 1 ) , and endothelial leukocyte adhesion molecule 1 ( ELAM 1 ) . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Involvement of the `` 1 ' ' domain of LFA 1 in selective binding to ligands ICAM 1 and ICAM 3 . ^^^ To analyze the binding requirements of LFA 1 for its two most homologous ligands , ICAM 1 and ICAM 3 , we compared the effects of various LFA 1 activation regimes and a panel of anti LFA 1 mAbs in T cell binding assays to ICAM 1 or ICAM 3 coated on plastic . ^^^ A screen of 29 anti LFA 1 mAbs led to the identification of two mAbs specific for the alpha subunit of LFA 1 which selectively blocked adhesion of T cells to ICAM 3 but not ICAM 1 . ^^^ Blocking was not due to a steric interference between anti LFA 1 mAbs and N linked carbohydrate residues present on ICAM 3 but not ICAM 1 . ^^^ Failure to induce ICAM 3 binding by mAb MEM 83 was not due to a blockade of the ICAM 3 binding site on LFA 1 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Induction of tyrosine phosphorylation during ICAM 3 and LFA 1 mediated intercellular adhesion , and its regulation by the CD 45 tyrosine phosphatase . ^^^ We have previously described the involvement of ICAM 3 in the regulation of LFA 1 / ICAM 1 dependent cell cell interaction of T lymphoblasts . ^^^ We have found that ICAM 3 is also able to mediate LFA 1 / ICAM 1 independent cell aggregation of the leukemic JM T cell line and the LFA 1 / CD18 deficient HAFSA B cell line . ^^^ In addition , inhibitors of tyrosine kinase activity also abolished ICAM 3 and LFA 1 mediated cell aggregation . ^^^ The induction of tyrosine phosphorylation through ICAM 3 and LFA 1 antigens was studied by immunofluorescence , and it was found that tyrosine phosphorylated proteins were preferentially located at intercellular boundaries upon the induction of cell aggregation by either anti ICAM 3 or anti LFA 1 alpha mAb . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Early hematopoietic CD34+ cells express CD 18 , CD11a , CD49d , CD49e , CD 44 , ICAM 1 , and ICAM 3 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
In this report , we investigated the role of intercellular adhesion molecule 3 ( ICAM 3 ) , the third identified ligand for the beta 2 integrin leukocyte function associated antigen 1 ( LFA 1 ) , in the regulation of leukocyte adhesion to ICAM 1 , vascular cell adhesion molecule 1 ( VCAM 1 ) , and the 38 and 80 kD fragments of fibronectin ( FN 40 and FN 80 ) . ^^^ We also studied the localization of ICAM 3 , LFA 1 , and the VLA beta 1 integrin , by immunofluorescence microscopy , on cells interacting with ICAM 1 , VCAM 1 and FN 80 . ^^^ Thus , ICAM 3 was almost exclusively concentrated in the most distal portion of the heading uropod whereas either LFA 1 or the VLA beta 1 integrin were uniformly distributed all over the large contact area . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
LFA 1 binding site in ICAM 3 contains a conserved motif and non contiguous amino acids . ^^^ The intercellular adhesion molecule 3 ( ICAM 3 ) is a counter receptor for the integrin LFA 1 that supports cell cell adhesion dependent functions . ^^^ Here , we characterize the overall shape of ICAM 3 and the amino acid residues involved in binding LFA 1 and monoclonal antibodies ( Mab ) . ^^^ Six out of nine ICAM 3 Mab described blocked the interaction with LFA 1 to varying degrees . ^^^ Domain assignment of blocking Mab epitopes and characterization of LFA 1 dependent cell adhesion to ICAM 3 mutants demonstrate that the amino terminal domain of ICAM 3 interacts with LFA 1 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
B cell homotypic adhesion through exon A restricted epitopes of CD 45 involves LFA 1 / ICAM 1 , ICAM 3 interactions , and induces coclustering of CD 45 and LFA 1 . ^^^ CD 45 mediated intercellular adhesion was abrogated upon incubation with anti leukocyte function associated antigen 1 ( anti LFA 1 ) , intercellular cell adhesion molecule 1 ( ICAM 1 ) , and ICAM 3 MoAbs , thus indicating that this phenomenon involved both LFA 1 / ICAM 1 and LFA 1 / ICAM 3 cell adhesion pathways . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
UVB irradiation of monocytes did result in reduction in the expression of HLA DR ( 30 % ) , LFA 3 ( 40 % ) , ICAM 1 ( 65 % ) AND B 7 1 and B 7 3 ( 90 % ) , but had no effect on CD 14 , LFA 1 and ICAM 3 expression . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The LFA 1 ligands involved in adhesion of resting CD 4 T cells to DC and alloreactive CD4+ T cells to specific DC differed in part , since ICAM 3 on resting T cells and ICAM 1 on alloreactive T lymphocytes preferentially bound LFA 1 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
We therefore examined the expression of the more recently identified LFA 1 ligand , ICAM 3 ( CD 50 ) , in comparison to ICAM 1 and ICAM 2 on blood DC and sought a functional role for ICAM 3 in DC mediated T lymphocyte responses . ^^^ However , the anti ICAM 3 mAb CAL 3 . 10 inhibited a DC stimulated MLR to a greater extent than anti ICAM 1 or anti ICAM 2 reagents and appeared to act by blocking the DC ICAM 3 T lymphocyte LFA 1 interaction . ^^^ As ICAM 3 is the predominant LFA 1 ligand on resting blood DC , we postulate that DC may utilize ICAM 3 for initial DC T lymphocyte interactions , and that ICAM 1 , which is up regulated upon DC activation , and / or ICAM 2 , may contribute to DC migration or later phases of the T lymphocyte activation process . . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The Ab induces binding of the LFA 1 expressing cell line , JY , to ICAM 1 ( CD 54 ) and ICAM 3 ( CD 50 ) . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The present study examined the presence on human LC of the LFA 1 ligands ICAM 2 ( CD 102 ) and ICAM 3 ( CD 50 ) and their functional role in the activation of allogeneic T cells . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies to epitopes within the mid to C terminal portion of the 1 domain and the N terminal portion of the region between the 1 domain and the EF hand like repeats gave good inhibition of LFA 1 dependent homotypic aggregation with cells that express either ICAM 1 or ICAM 3 as the major LFA 1 ligand . . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule ( ICAM ) 1 , ICAM 2 , and ICAM 3 have been identified as counter receptors for the leukocyte integrin lymphocyte function associated antigen 1 ( LFA 1 ) . ^^^ Despite extensive differences in N linked glycosylation , ICAM 3 purified from lymphoid cells and from neutrophils supports adhesion of LFA 1 bearing cells equally well ; however , neither supports adhesion of Mac 1 or p 150 , 95 expressing chinese hamster ovary cell transfectants . ^^^ Heterogenous glycosylation of ICAM 3 and lack of interaction with Mac 1 and p 150 , 95 . ^^^ ICAM 1 and ICAM 3 are highly homologous , and an undefined ligand for Mac 1 is present on neutrophils where ICAM 3 is well expressed . ^^^ We therefore sought to characterize ICAM 3 heterogeneity and determine whether ICAM 3 was a ligand for either Mac 1 or p 150 , 95 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Three counter receptors for LFA 1 of the immunoglobulin family have been discovered : ICAM 1 , ICAM 2 , and ICAM 3 . ^^^ The finding that ICAM 3 is much better expressed than other LFA 1 ligands on monocytes and resting T cells , and that this discovery may be important in the initiation of immune responses prompted us to search for the expression of ICAM 3 by human epidermal Langerhans cells ( LC ) . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule 3 ( ICAM 3 , CD 50 ) is a member of the immunoglobulin superfamily and is a constitutively expressed ligand for the leukocyte integrin LFA 1 ( CD11a / CD18 ) . ^^^ ICAM 3 is expressed at high levels by all resting leukocyte populations and antigen presenting cells and is a major ligand for LFA 1 in the resting immune system . ^^^ Mutant ICAM 3 Fc chimeric proteins were quantitatively analyzed for their ability to bind COS cells expressing human LFA 1 . ^^^ The LFA 1 binding site on ICAM 3 is located in the N terminal 2 Ig domains . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The intercellular adhesion molecule 3 ( ICAM 3 ) has been identified as the third LFA 1 ligand in addition to ICAM 1 and ICAM 2 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule 3 ( ICAM 3 , CD 50 ) , a member of the immunoglobulin gene superfamily , is a major ligand for the lymphocyte function associated antigen 1 ( LFA 1 , CD18 / CD11a ) in the resting immune system and plays a role as a signaling and costimulatory molecule on T lymphocytes . ^^^ By using an adhesion assay employing COS cells expressing LFA 1 binding to recombinant chimeric ICAM 3 Fc proteins ( which overcomes the confounding effects of interleukocyte LFA 1 / ICAM binding events ) , we have been able to examine the effects of these antibodies in blocking LFA 1 / ICAM 3 adhesion . ^^^ Our data suggests that only a small minority of ICAM 3 mAb , recognizing a distinct epitope , are able to mimic the effects of LFA 1 binding to ICAM 3 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
We have characterized the immunobiology of the interaction of intercellular adhesion molecule 3 ( ICAM 3 ; CD 50 ) with its counter receptor , leukocyte function associated antigen 1 ( LFA 1 ; CD11a / CD18 ) . ^^^ Purified ICAM 3 supported LFA 1 dependent adhesion in a temperature and cation dependent manner . ^^^ Activation of cells bearing LFA 1 increased adhesiveness for ICAM 3 in parallel to adhesiveness for ICAM 1 . ^^^ Although CBR IC3 / 1 monoclonal antibody ( mAb ) blocked adhesion of cells to purified LFA 1 , when tested alone , neither CBR IC3 / 1 nor five novel ICAM 3 mAbs characterized here blocked adhesion of cells to purified ICAM 3 or homotypic adhesion . ^^^ Two ICAM 3 mAbs , CBR IC3 / 1 and CBR IC3 / 2 , were required to block LFA 1 dependent adhesion to purified ICAM 3 or LFA 1 dependent , ICAM 1 , ICAM 2 independent homotypic adhesion of lymphoid cell lines . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The chicken beta 2 can associate on the cell surface with the human alpha subunit of LFA 1 and yields a hybrid molecule capable of binding to purified ICAM 1 and ICAM 3 . . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
LFA 1 ( CD11a / CD18 ) mediates leukocyte adhesion by binding to one of its ligands : ICAM 1 , ICAM 2 or ICAM 3 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
These results indicate that the interaction between LFA 1 and ICAM is a critical step in HIV mediated syncytia formation , and that ICAM 1 , ICAM 2 and ICAM 3 are the receptor molecules for the LFA 1 dependent syncytia formation . . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
U 266 and IM 9 myeloma cell lines express mainly CD 29 , CD49d , VLA 1 , CD 18 , CD 54 , ICAM 2 and ICAM 3 . ^^^ The combination of these MoAbs ( anti CD 29 , CD 18 , CD11a , CD49d , VLA 5 , CD 44 , CD 54 , ICAM 2 , ICAM 3 MoAbs ) decreased but did not completely abrogate binding of IM 9 to BMSCs . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
These results suggest that other DC ligands for LFA 1 , perhaps ICAM 3 , may be present on DC and act as the major functional ligand for T cell activation . . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Based on protein sequence , we have isolated a cDNA for intercellular adhesion molecule 3 ( ICAM 3 ) , the most recently defined counter receptor for lymphocyte function associated antigen 1 ( LFA 1 ) . ^^^ Expression of the cDNA yields a product that reacts with monoclonal antibody to ICAM 3 and functions as a ligand for LFA 1 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Recent functional studies have shown that ICAM 3 is a ligand for LFA 1 , and plays an important part in immune reactions . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The ICAM 3 / LFA 1 interaction is critical for epidermal Langerhans cell alloantigen presentation to CD4+ T cells . ^^^ These data indicate that ICAM 3 is constitutively expressed by Langerhans cells and is a major ligand for LFA 1 on CD4+ T cells during their response to Langerhans cells . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
In the present study , we used a series of human / murine CD11a 1 domain chimeras , to localize a fourth 1 domain epitope ( IdeD ) , recognized by three independently derived anti CD11a antibodies that selectively block the binding of LFA 1 to ICAM 3 , but not to ICAM 1 . ^^^ Although mutation of Asp 182 and Ser 184 failed to abolish ICAM 3 adhesion of LFA 1 transfectants , alignment of these residues with the crystal structure of the CD11a 1 domain suggested that the IdeD epitope is located in close proximity to residues ( Ile 126 and Asn 129 ) recently implicated in the ICAM 3 binding site . ^^^ Taken together , these data indicate that distinct regions of the CD11a 1 domain contain epitopes for antibodies that either selectively inhibit binding of LFA 1 to ICAM 3 , or interfere with both ICAM 1 and ICAM 3 binding of LFA 1 . . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
ICAM 3 , a ligand of LFA 1 , is thought to mediate intercellular adhesion essential for the initiation of immune responses . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Engagement of the CD 45 molecule induces homotypic adhesion of human thymocytes through a LFA 1 / ICAM 3 dependent pathway . ^^^ Finally , because inhibitions observed with mAbs against LFA 1 and ICAM 3 are only partial , it can be assumed that another adhesion pathway is involved in thymocyte adhesion . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The mechanism underlaying this activation appear to involve the interaction of ICAM 3 with a beta 2 integrin , likely to be LFA 1 , since mAb to the CD 18 chain completely inhibited T cell activation . ^^^ ICAM 3 , the third LFA 1 counterreceptor , is a co stimulatory molecule for both resting and activated T lymphocytes . ^^^ Soluble ICAM 3 , anti ICAM 3 and anti CD 3 mAb were utilized to address the role of the ICAM 3 / LFA 1 pathway in TcR / CD3 dependent or independent T cell activation . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Our results indicate that ICAM 3 is the main LFA 1 counter receptor in human resident epidermal Langerhans cells . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
LFA 1 / ICAM 3 mediates neutrophil homotypic aggregation under fluid shear stress . ^^^ Furthermore , this neutrophil aggregation under fluid shear stress was completely inhibited by pretreatment with antibody against LFA 1 or ICAM 3 . ^^^ These results suggested that NiCl 2 sensitive Ca2+ channel played an important role in LFA 1 / ICAM 3 mediated neutrophil homotypic aggregation under fluid shear stress . . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Furthermore , LFA 1 and ICAM 1 , but not ICAM 3 ( the third ligand for LFA 1 ) were observed in the interstitial foam cells . ^^^ LFA 1 and ICAM 3 were observed mainly in interstitial infiltrating cells , but ICAM 1 was observed to a much lesser extent in these cells . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Three ligands have been described for the leucocyte integrin LFA 1 , namely intercellular adhesion molecule ( ICAM ) 1 , ICAM 2 , and ICAM 3 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Cell interaction molecules lymphocyte function associated antigen 1 ( LFA 1 ) ( CD11a ) , intracellular adhesion molecule 1 ( ICAM 1 ) ( CD 54 ) , ICAM 3 ( CD 50 ) and B7 . 2 ( CD 86 ) were up regulated on HL 60 R 7 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Localization of the binding site on intercellular adhesion molecule 3 ( ICAM 3 ) for lymphocyte function associated antigen 1 ( LFA 1 ) . ^^^ Intercellular adhesion molecule 3 ( ICAM 3 ; CD 50 ) is the predominant counter receptor on resting T cells and monocytes for the leukocyte integrin , lymphocyte function associated antigen 1 ( LFA 1 ; CD11a / CD18 ) , and may play an important role in the initial stages of the T cell dependent immune response . ^^^ Deletion of individual immunoglobulin superfamily ( IgSF ) domains of ICAM 3 and ICAM 3 IgSF domain chimeras with CD 21 showed there is a single LFA 1 binding site in ICAM 3 and that IgSF domain 1 is necessary and sufficient for LFA 1 binding . ^^^ Epitope mapping and functional studies performed with 17 anti ICAM 3 monoclonal antibodies demonstrated that only some monoclonal antibodies , with epitopes wholly within domain 1 of ICAM 3 , were able to block binding of ICAM 3 bearing cells to purified LFA 1 , in agreement with the data obtained from the domain deletion mutants and CD 21 chimeras . ^^^ Analysis of a panel of 45 point mutants of domain 1 of ICAM 3 identified five residues that may contact LFA 1 as part of the binding site , Asn 23 , Ser 25 , Glu 37 , Phe 54 , and Gln 75 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
To identify potential molecular substrates for leukocyte trafficking and activation in multiple sclerosis ( MS ) brain , we determined the immunocytochemical distribution of the beta , integrin lymphocyte function associated antigen 1 ( LFA 1 ) and its major ligands , intercellular adhesion molecule ( ICAM ) 1 , ICAM 2 , and ICAM 3 in MS tissue . ^^^ Both ICAM 3 and LFA 1 were detected on the vast majority of infiltrating lymphocytes and monocytes in and near MS lesions , and these cells were often closely apposed to each other . ^^^ ICAM 3 positive leukocytes were often closely apposed to LFA 1 positive microglia . ^^^ These results suggest a role for ICAM 1 , 2 , and LFA 1 in the transendothelial migration of leukocytes into MS brain and a role for ICAM 3 / LFA 1 interactions in the activation of lymphocytes , monocytes , and microglia in MS lesions . . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Immunohistochemistry was performed for CD 18 , CD11a , CD11b , CD11c , alpha d , ICAM 1 , ICAM 2 , and ICAM 3 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
ICAM 3 / CD50 is a recently described LFA 1 counter receptor that seems to play an important role in the initiation of immune responses . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
We have previously reported that a physiological range of shear stress induces neutrophil homotypic aggregation mediated by lymphocyte function associated antigen 1 ( LFA 1 ) and intercellular adhesion molecule 3 ( ICAM 3 ) interactions . ^^^ This shear stress induced actin polymerization was not observed when neutrophils were pretreated with anti LFA 1 or anti ICAM 3 antibody . ^^^ In conclusion , LFA 1 and ICAM 3 interaction mediated by the increase of [ Ca2+ ] 1 generated the intercellular signal in order to accumulate F actin in the cell cell contact regions . . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
CD 50 ( ICAM 3 ) has been identified as the third CD11a / CD18 ( LFA 1 ) counter receptor . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
In the normal conjunctiva , intercellular adhesion molecule 1 ( ICAM 1 ) was expressed only on the vascular endothelium , lymphocyte function associated antigen 1 ( LFA 1 ) and intercellular adhesion molecule 3 ( ICAM 3 ) on epithelial and stromal mononuclear cells , and very late activation antigen 4 ( VLA 4 ) on a few stromal mononuclear cells . ^^^ LFA 1 and ICAM 3 were expressed on the majority of infiltrating mononuclear cells . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Lymphocyte function associated antigen 1 ( LFA 1 ) is able to bind selectively to its ligands intercellular adhesion molecules 1 and 3 ( ICAM 1 and ICAM 3 ) , suggesting that LFA 1 can exist in distinct ligand specific binding states . ^^^ We have investigated the role of ligands ( ICAM 1 and ICAM 3 ) in LFA 1 activation by using ICAM blocking monoclonal antibodies and a fixation protocol for `` freezing ' ' LFA 1 on the surface of cells after prior exposure to ICAM 1 and ICAM 3 . ^^^ These studies not only confirm that LFA 1 exists in distinct ICAM specific activation states , but also demonstrate that ICAM 1 plays a role in the activation of LFA 1 binding to ICAM 3 . . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
RESULTS : Conjunctival dendriform cells reliably expressed several antigens : class 2 antigens HLA DR and HLA DQ , CD1a , vimentin , CD11a and CD 18 ( LFA 1 ) , CD 14 , CD 22 , CD 36 , CD45RO , ICAM 3 and CD 63 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
At the initial biopsy , there was no difference in the degree of glomerular C3c deposition , glomerular intercellular adhesion molecule ( ICAM ) 1 expression , or the numbers of cells bearing leukocyte function associated antigen 1 ( LFA 1 ) , Mac 1 , and ICAM 3 between the two groups . ^^^ At the follow up biopsy , the degree of glomerular C3c deposition , and the numbers of cells bearing LFA 1 , Mac 1 , and ICAM 3 , were significantly decreased only in group A ( P < 0 . 01 , P < 0 . 001 , P < 0 . 001 , and P < 0 . 01 , respectively ) . ^^^ The number of cells bearing LFA 1 was positively correlated with that of cells bearing ICAM 3 ( P < 0 . 00001 ) . ^^^ These results suggest that the glomerular leukocytes , infiltrating through Mac 1 / complement interaction , express ICAM 3 by themselves , and that LFA 1 / ICAM 3 interaction might participate in the glomerular aggregation of leukocytes in MPGN type 1 . ^^^ Most of Mac 1 positive cells were CD 15 positive cells ( granulocytes / monocytes ) , and a considerable number of Mac 1 positive cells concurrently expressed ICAM 3 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
RANTES stimulation of T lymphocyte adhesion and activation : role for LFA 1 and ICAM 3 . ^^^ Intercellular adhesion molecule 3 ( ICAM 3 ) and possibly ICAM 1 participate as LFA 1 ligands . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The expression of two adhesion molecules , ICAM 1 ( CD 54 ) and ICAM 3 ( CD 50 ) , infiltrating cells positive for their ligand , LFA 1 ( CD11a ) , and the markers of total leukocytes ( CD 45 ) , T cells ( CD 3 ) , granulocytes / monocytes ( CD 15 ) , and macrophages ( CD 68 ) in renal interstitium were examined by an indirect immunoperoxidase method . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The constitutive high expression of CD 50 ( ICAM 3 ) on resting leukocytes , coupled with the observation that CD 50 is the primary LFA 1 ligand on resting T cells , suggests that CD 50 may be an important LFA 1 ligand in the initiation of the immune / inflammatory response . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule 3 ( ICAM 3 ) , the third receptor for the lymphocyte function associated antigen molecule 1 ( LFA 1 ) was recently characterized . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Immunohistopathological studies were performed on cryostat sections of bucal mucosa biopsies using antibodies to CD 3 , CD 4 , CD 8 , CD 20 , CD 14 , CD 25 , LFA 1 , ICAM 3 HLA class 2 , tumor necrosis factor alpha , interleukin 1 , and interferon gamma . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Notably , antibodies directed against VLA 4 , other beta 2 integrins ( Mac 1 and p 150 ) , or other potential LFA 1 counterstructures that were expressed on the cell surface ( ICAM 1 and ICAM 3 ) did not block aggregation . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
There was decreased percentage expression of CD11a , CD 18 , and ICAM 3 in Crohn ' s disease and ulcerative colitis compared with normal , but an increased MFI for these molecules among patients with Crohn ' s disease . ^^^ We hypothesize that the decreased percentage expression and increased MFI of CD11a , CD 18 , and ICAM 3 may suggest that cells up regulate these ligands following activation and are egressing into tissue . . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The interactions of intercellular adhesion molecules 1 and 3 ( ICAM 1 and ICAM 3 ) with lymphocyte function associated antigen 1 ( LFA 1 ) have been characterized and compared on the molecular and cellular level . ^^^ Enzyme linked immunosorbent based molecular assays have been utilized to calculate the binding affinities of soluble ICAM 1 ( sICAM 1 ) and soluble ICAM 3 ( sICAM 3 ) for LFA 1 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Immunohistochemistry was performed for CD 18 , CD11a , CD11b , CD11c , alphad , ICAM 1 , ICAM 2 , and ICAM 3 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
We used a panel of specific monoclonal antibodies ( mAbs ) directed against intercellular adhesion molecule 1 ( ICAM 1 ) , intercellular adhesion molecule 3 ( ICAM 3 ) , lymphocyte function associated antigen 1 ( LFA 1 ) , very late activation antigen 4 ( VLA 4 ) , vascular cell adhesion molecule 1 ( VCAM 1 ) , and endothelial leucocyte adhesion molecule 1 ( ELAM 1 ) In addition , a panel of mAbs were used to characterise the composition of the inflammatory infiltrate . ^^^ RESULTS : In the normal conjunctiva , ICAM 1 was expressed on the vascular endothelium only , LFA 1 and ICAM 3 on epithelial and stromal mononuclear cells , and VLA 4 on stromal mononuclear cells . ^^^ LFA 1 and ICAM 3 were expressed on the majority of epithelial and stromal infiltrating mononuclear cells . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Adhesion molecules identified were intercellular adhesion molecule 1 ( ICAM 1 ) , ICAM 2 , ICAM 3 , vascular cell adhesion molecule 1 ( VCAM 1 ) , platelet endothelial cell adhesion molecule 1 ( PECAM 1 ) , E selectin , P selectin , L selectin , lymphocyte function associated antigen 1 ( LFA 1 ) , and very late activation antigen 4 ( VLA 4 ) . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The expression of ICAM 1 , ICAM 3 , LFA 3 , CD 2 , LFA 1 , VLA 4 , CD1a , VCAM 1 , CD 69 , and activated b 1 integrins were assessed by immunostaining . ^^^ An increased expression of LFA 1 , LFA 2 , ICAM 3 , VLA 4 , and activated b 1 integrins was observed in the cell infiltrate of actinic prurigo lesions and an up regulated expression of ICAM 1 was detected in keratinocytes from these specimens . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The leukocyte differentiation antigen CD 50 ( intercellular adhesion molecule 3 , ICAM 3 ) , mediates cell cell adhesion through its ligand LFA 1 and is a transducting receptor molecule during T cell activation . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
This alteration in co stimulatory molecule expression was selective , because UV Mphi express equal levels of ICAM 1 and ICAM 3 , and increased levels of LFA 1 , relative to LC . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The increased binding induced by both cytokines and the TNF alpha induced sensitivity of SR 91 cells to NK 92 cell killing were abrogated by anti LFA 1 mAb as well as by a combination of antibodies against the three ligands of LFA 1 ( CD11a / CD18 ) , ICAM 1 ( CD 54 ) , ICAM 2 ( CD 102 ) and ICAM 3 ( CD 50 ) . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
At relatively low shear rates ( 100 200 s ( 1 ) ) firm adhesion is mediated in equal measure by LFA 1 binding to ICAM 3 , and Mac 1 binding to an as yet undefined ligand . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Activated neutrophils aggregate in a shear field via bonding of L selectin to P selectin glycoprotein ligand 1 ( PSGL 1 ) followed by a more stable bonding of LFA 1 ( CD11a / CD18 ) to intercellular adhesion molecule 3 ( ICAM 3 ) and Mac 1 ( CD11b / CD18 ) to an unknown counter receptor . ^^^ Assuming that the Mac 1 counter receptor is ICAM 3 like in strength and number , rate processes were deconvoluted from neutrophil homoaggregation data for shear rates ( G ) of 100 3000 s 1 with a two body hydrodynamic collision model ( . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
A significant higher expression of CD 29 ( beta 1 integrin ) ( p = 0 . 001 ) , VLA 3 ( p = 0 . 002 ) , VLA 4 ( p = 0 . 03 ) , and VLA 5 ( p = 0 . 001 ) were observed on PBMCs of chronic alcoholics , compared with control subjects , whereas no changes were observed in CD 18 ( beta 2 integrin ) and CD 50 ( ICAM 3 ) expression . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Alteration of ICAM 3 on apoptotic cells permitting recognition by macrophages resulted in a switch in ICAM 3 binding preference from the prototypic ICAM 3 counterreceptor , LFA 1 , to an alternative macrophage receptor . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Human T cell leukaemia / lymphoma virus type 1 syncytium formation is regulated in a cell specific manner by ICAM 1 , ICAM 3 and VCAM 1 and can be inhibited by antibodies to integrin beta 2 or beta 7 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
While the virus particle gained several molecules when passed through the different cell lines ( e . g . , ICAM 3 , LFA 1 , ICAM 1 , or MHC class 2 ) , BZ 167 never incorporated significant levels of CXCR 4 , CCR 5 , or CCR 3 into its envelope even though some or all of the cell lines in which it was grown expressed them . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Furthermore , most of interstitial foam cells were positive for both leukocyte function associated antigen 1 ( LFA 1 ) and intercellular adhesion molecule 1 ( ICAM 1 ) , but not for ICAM 3 ( the third ligand for LFA 1 ) . ^^^ By contrast , most of infiltrating nonfoamy M phi s were positive for ICAM 3 and LFA 1 , however , ICAM 1 was observed on only some of them . ^^^ The accumulation of foam cells , which have characteristics of mature M phi , may be related to ICAM 1 as a ligand of LFA 1 , whereas infiltration of nonfoamy M phi s has a close relationship with ICAM 3 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The LFA 1 adhesion molecule is involved in cell adhesion events of leukocytes through binding to ICAM 1 , ICAM 2 and ICAM 3 . ^^^ Interestingly , we observed that LFA 1 / ICAM 1 co stimulation of T cells resulted in high production of the Th 2 cytokine IL 10 compared to ICAM 2 or ICAM 3 co stimulation . ^^^ In contrast , ICAM 2 and ICAM 3 induced a much stronger secretion of the Th 1 cytokine TNF alpha compared to LFA 1 / ICAM 1 induced co stimulation , despite the lower proliferation rate . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
We found that an HLA DR+ subclone ( HEL DR+ ) expresses LFA 1 , LFA 3 , ICAM 1 , ICAM 3 , but neither CD 80 nor CD 86 on the surface . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Interestingly , although inhibitable by two of six mAbs against LFA 1 , HMC 1 aggregation induced via ICAM 3 appears to be mediated by an adhesive pathway independent of LFA 1 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Adhesion molecules identified were intercellular adhesion molecule 1 ( ICAM 1 ) , ICAM 2 , ICAM 3 , vascular cell adhesion molecule 1 ( VCAM 1 ) , platelet endothelial cell adhesion molecule 1 ( PECAM 1 ) , E selectin , P selectin , L selectin , lymphocyte function associated antigen 1 ( LFA 1 ) , very late activation antigen 4 ( VLA 4 ) , Mac 1 ( CD18 / CD11b ) , and gp 150 , 95 ( CD18 / CD11c ) . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule 3 ( ICAM 3 , CD 50 ) is an immunoglobulin ( Ig ) domain containing cell cell adhesion receptor that binds to the lymphocyte function antigen 1 ( LFA 1 ; CD11a / CD18 ) integrin . ^^^ ICAM 3 / LFA 1 binding during a lymphocyte mediated cellular immune response has been well established ; however , its role in the marrow compartment is unclear . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
BACKGROUND : ICAM 3 has been recently identified as the third leukocyte function associated 1 ( LFA 1 ) ligand . ^^^ RESULTS : Peripheral blood eosinophils constitutively expressed low levels of ICAM 1 and ICAM 2 ( < 10 FMI ) , moderate levels ( 10 50 FMI ) of CD 29 and L selectin , and high levels ( > 50 FMI ) of ICAM 3 , LFA 1 , and Mac 1 . ^^^ L selectin expression decreased at 6 and 24 h , but ICAM 2 , ICAM 3 , LFA 1 , and CD 29 expression did not show any significant change after calcium ionophore stimulation . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
We discovered that instead of the common ICAM 3 receptors LFA 1 and alphaDbeta 2 , a novel DC specific C type lectin , DC SIGN , binds ICAM 3 with high affinity . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Serial colonic sections ( 10 UC , 10 CD , and 10 controls ) were stained immunohistochemically for ICAM 1 , ICAM 2 , ICAM 3 , CD11a , CD11b , CD 18 , and PECAM 1 . ^^^ In conclusion , CD11b , CD 18 , and ICAM 2 seem to be important for PMN transepithelial migration in UC , whereas CD11a , CD11c , ICAM 1 , and ICAM 3 seem central in leukocyte locomotion and aggregation in CD . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
LFA 1 and its ligands , ICAM 1 , ICAM 2 , and ICAM 3 , can be expressed on the cells infected by HIV , as well as on the HIV virions themselves . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Agglutination induced by A 80 was inhibited by stromal cell derived factor 1 , T 22 , and phorbol 12 myristate 13 acetate but was not significantly altered by pretreatment of cells with pertussis toxin , wortmannin , or MAbs to LFA 1 , ICAM 1 , ICAM 2 , and ICAM 3 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Binding of LFA 1 ( CD11a ) to intercellular adhesion molecule 3 ( ICAM 3 ; CD 50 ) and ICAM 2 ( CD 102 ) triggers transmigration of human immunodeficiency virus type 1 infected monocytes through mucosal epithelial cells . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
We have investigated the interaction between ICAM 3 and ezrin / radixin / moesin ( ERM ) proteins and its role in LFA 1 induced cell cell interactions and membrane positioning of ICAM 3 in polarized migrating lymphocytes . ^^^ This interaction was not essential for the binding of ICAM 3 to LFA 1 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Fluorescence activated cell sorting analyses showed that neither tumors nor ascitic cells grown in SCID mice expressed leukocyte function associated antigen ( LFA ) 1alpha ( CD11a ) , LFA 1lbeta ( CD 18 ) , LFA 2 ( CD 2 ) , LFA 3 ( CD 58 ) , intercellular adhesion molecule ( ICAM ) 1 ( CD 54 ) , ICAM 2 ( CD 102 ) , ICAM 3 ( CD 50 ) , or leukocyte endothelial adhesion molecule ( LECAM ) 1 ( CD62L ) , suggesting that these cytoadhesion molecules are not involved in tumor formation of RM P 1 cells in vivo . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Although the integrin LFA 1 is a counter receptor for both ICAM 2 and ICAM 3 , on DC , DC SIGN is the high affinity adhesion receptor for ICAM 2 / 3 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Only SB 203580 could reverse the effect on CD11b , CD 18 , and ICAM 3 expressions . ^^^ Therefore , the expression of ICAM 1 might involve both p 38 MAPK and NF kappaB activities , whereas the regulation of CD11b , CD 18 , and ICAM 3 expressions might be mediated through p 38 MAPK but not NF kappaB . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The beta ( 2 ) integrin LFA 1 ( CD11a / CD18 ) is a leukocyte specific adhesion molecule that mediates leukocyte extravasation , antigen presentation , and T cell mediated cytolysis through its interaction with its counter receptors , ICAM 1 , ICAM 2 , and ICAM 3 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The aim of this study was to investigate adhesion molecule expression ( ICAM 1 , ICAM 3 , VCAM 1 , LFA 1 and ELAM 1 ) by using an immunophosphatase alkaline ( APAAP ) technique in a double blind controlled study . ^^^ In group A , ICAM 1 positive cells decreased from 75 . 8 ( SE + / 15 . 12 ) to 38 . 8 ( SE + / 7 . 57 ) ICAM 3 positive cells decreased from 61 . 7 ( SE + / 12 . 72 ) to 45 . 2 ( SE + / 9 . 44 ) and LFA 1 decreased from 103 . 9 ( SE + / 17 . 34 ) to 66 . 5 ( SE + / 8 . 63 ) after cetirizine treatment ( p = 0 . 02 ) . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
In a comparison of LFA 1 ligands , intercellular adhesion molecule 2 ( ICAM 2 ) and ICAM 3 promoted LFA 1 directed perforin release , whereas ICAM 1 had little effect . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
DLGL are CD56bright and express the CD 2 , CD11a , CD 18 , CD 38 and CD 50 molecules , dimly the CD 54 molecule , and poorly the CD 102 and CD 69 molecules . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
We pulsed cells of monocytoid lineage ( established and primary ) and CD 4 negative epithelial cells transiently expressing DC SIGN or LFA 1 with isogenic HIV 1 particles either devoid or bearing host derived ICAM 1 or ICAM 3 before incubation with an indicator cell line . ^^^ To our surprise , the ICAM 1 / LFA 1 association was a more efficient transmission factor than the combined gp120 / DC SIGN and ICAM 3 / DC SIGN interactions . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
This triggers binding of ligands to LFA 1 that are shared with DC SIGN , such as ICAM 3 , but not of ligands that are not shared with DC SIGN , such as ICAM 1 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Binding of ICAM 3 , and ICAM 1 to a lesser extent , to LFA 1 expressed by mature but not immature DC , induced MHC 2 clustering into the immune synapse . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Resting BAL CD4+ T cells constitutively express high levels of HLA DP , lymphocyte function associated antigen 1 ( LFA 1 ) and ICAM 3 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
These responses were specific for CD 53 , as cross linking of CD11a , CD 18 , CD 35 , CD 43 , CD 44 , CD 45 , or CDw 50 did not induce leukocyte activation . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The constitutive high expression of CD 50 on resting leukocytes suggests that it is an important LFA 1 ligand in the initiation of the immune / inflammatory response . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
When the reactivity of mNI 11 and mAbs binding human differentiation antigens such as CD11a , CD11b , CD11c , CD 14 , CD 16 , CD 18 , CD 23 , CD 28 , CD 29 , CD 31 , CD 43 , CD 44 , CD45RA , CD49d , CD 50 , CD 54 , CD 58 , CD 80 , CD 102 , CD 106 , HLA class 1 , or HLA class 2 antigen was compared , no mNI 11 reactivity resembling that of these mAbs was found . mNI 11 markedly induced homotypic cell aggregation of U 937 cells when they were stimulated with LPS . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Incubation of CLC with monoclonal antibodies against HLA DR , CD11b , CD 18 , CD 50 , CD 54 , CD 58 or CD 80 , but not anti major histocompatibility complex class 1 ( MHC 1 ) , inhibited antigen specific T cell proliferation to varying degrees . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
FDCs were immunochemically positive for Mac 1 ( CD11b ) , sialyl Lex ( CD15s ) , CD 22 , integrin beta 1 ( CD 29 ) , CD 40 , very late activation antigen ( VLA ) alpha 3 ( CD49c ) , VLA alpha 5 ( CD49e ) , VLA alpha 6 ( CD49f ) , intercellular adhesion molecule ( ICAM ) 3 ( CD 50 ) , ICAM 1 ( CD 54 ) , B 7 ( CD 80 ) , and vascular cell adhesion molecule ( VCAM ) 1 ( CD 106 ) . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
When the reactive patterns between mNI 58A and the mAbs to various human differentiation antigens ( CD11a , CD11b , CD11c , CD 14 , CD 16 , CD 18 , CD 23 , CD 28 , CD 29 , CD 31 , CD 43 , CD 44 , CD45RA , CD 50 , CD 54 , CD 58 , CD 80 , CD 102 , CD 106 , HLA class 1 and class 2 antigen ) were compared , that of mNI 58A was found to be similar to those of the leukocyte function associated antigen 1 ( LFA 1 ) mAbs . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
RESULTS : Conjunctival dendritic cells exhibited surface markers both in normal and inflammatory conditions : class 2 antigens HLA DR and HLA DQ , CD1a , vimentin , CD11a and CD 18 ( LFA 1 ) , CD 22 , CD45RO and CD 50 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
When the reactivity of mNKES and mouse mAbs recognizing the human adhesion associated antigen ( CD 10 , CD11a , CD11b , CD11c , CD 14 , CD 16 , CD 18 , CD 23 , CD 28 , CD 29 , CD 31 , CD 43 , CD 44 , CD45RA , CD 50 , CD 54 , CD 58 , CD 80 , CD 102 , CD 106 , and HLA class 1 , and HLA class 2 antigen ) with various cell lines was compared , mNKES reactivity was found to be unique , not resembling that of any of these mouse mAbs . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
CBDC expressed the CD 4 , CD11a , CD 18 , CD45RA , CD 50 and CD 54 antigens but revealed no expression of the CD1a , CD11c , CD 40 , CD45R0 , CD 58 , CD 83 , CD 86 and CD 102 antigens . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
CBDC expressed CD 4 , CD11a , CD 18 , CD45RA , CD 50 , CD 54 , and CD 123 , but showed no expression of CD1a , CD11c , CD 33 , CD 40 , CD45R0 , CD 80 , CD 83 , and CD 86 and only limited expression of CD 58 , CD 102 , and CD 116 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Interestingly , the reactivity of gammadelta T cells against mycobacterial antigens was significantly increased by costimulatory signals generated through CD 7 , LFA 1 , CD 50 and CD 69 in all groups . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
In fact , depending on the environment ( organ ) , stage of cell maturation , type of disease , and other factors , MC express variable amounts of activation linked antigens ( CD 25 , CD 63 , CD 69 , CD 88 ) , cell recognition molecules ( CD 2 , CD 11 , CD 18 , CD 50 , CD 54 ) , or cytokine receptors . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
They expressed CD 4 , CD11a , CD11b , CD11c , CD 18 , CD 32 , CD 33 , CD45R0 , CD 48 , CD 50 , CD 54 , CD 58 , CD 64 , CD 86 , CD 102 , CD 116 , CD 123 , and HLA DR ; showed no expression of CD1a and CD 83 ; and weak expression of CD 16 , CD45RA , and CD 80 . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Neutrophil expression of CD 64 , CD 43 , CD 44 , CD 50 , CD62L and Mac 1 , and plasma levels of interleukin ( IL ) 1beta , IL 6 , tumor necrosis factor alpha ( TNF alpha ) and soluble L selectin ( sCD62L ) , were determined . ^^^ In contrast , we found that plasma levels of IL 1beta and sCD62L , as well as the expression of Mac 1 , CD 43 , CD 44 , CD 50 , and CD62L , do not appear to be useful for the diagnosis of NS . . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
Cell surface expression of CD 18 , CD11a , CD11b , CD11c , CD 50 , and CD 54 was not affected by Na ( 2 ) SO ( 3 ) treatment . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
The research included study of co expression of adhesion molecules , belonging to the following families : beta 2 integrins ( CD 11 beta , CD 18 ) , immunoglobulins ( CD 50 ) , and CD 38 on tumor blood B lymphocytes of various CD types and T lymphocytes in chronic leucosis . ^^^
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32942 and P05107	Pubmed	SVM Score :0.0
NA