Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Two leukocyte integrins , alpha M beta 2 ( CD11b / CD18 , Mac 1 ) and alpha 10 beta 2 ( CD11c / CD18 , p 150 , 95 ) , are the main fibrinogen receptors expressed on neutrophils , monocytes , macrophages and several subsets of lymphocytes . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
An antibody ( LeuM 5 ) to the CD11c antigen ( p150 . 95 ) gave the highest level of inhibition , and anti CD11a ( LFA 1 ) also was inhibitory , while anti CD 56 ( NKH 1 ) or anti CD11b did not interfere with adhesion to plastic . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Such macrophages also expressed CD 4 ( Leu 3a and 3b ) and 2H4 , which are the cell membrane determinants of suppressor inducer T lymphocyte ; CD 2 ( Leu 5b ) , which is a marker of pan T cell ; Leu M 3 , Leu M 5 and Mac 1 , which are the markers of monocyte and macrophage lineage ; leukocyte common antigen , which is a marker of bone marrow derived cell ; and alpha antichymotrypsin , which is a glycoprotein associated with macrophages . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Granulocytes from patients genetically deficient in the leukocyte glycoprotein family , Mo 1 , LFA 1 , and Leu M 5 ( P 150 , 94 ) , have defective complement receptor type 3 ( CR 3 ) activity as well as abnormal adhesion dependent functions such as spreading , chemotaxis , and phagocytosis . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Each of the three antigens , Mo 1 , LFA 1 , and Leu M 5 has a distinct alpha subunit noncovalently associated with a common beta subunit that appears to be required for the expression of these antigens on the cell surface . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The leukocyte adhesion 90 kDa glycoprotein GP 90 ( antigen CD 18 ) is non covalently associated separately with cell surface glycoproteins GP 160 ( antigens CD11a , TA 1 , LFA 1 ) , GP 155 ( antigens CD11b , OKM 1 , MO 1 ) or GP 130 ( antigens CD 11c , Leu M 5 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Approximately 60 % of T 6 Dr+ UV EC bore the monocyte marker defined by monoclonal antibody OKM 5 , but lacked determinants recognized by OKM 1 , Leu M 1 , Leu M 3 , Leu M 4 , Leu M 5 , and Mac 1 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
By immunofluorescence analysis , CD11b and CD 18 monoclonal antibodies specific for the 155 kd alpha polypeptide of Mo 1 ( gp 155 , 94 ) and the 94 kd beta peptide common to Mo 1 , LFA 1 ( gp 170 , 94 ) , and Leu M 5 ( p 150 , 94 ) ( surface molecules that promote leukocyte adhesion ) failed to bind to unstimulated and A 23187 calcium ionophore stimulated granulocytes or mononuclear cells of the affected dog as compared with strong specific binding to canine control cells . ^^^ Deficiency of leukocyte surface glycoproteins Mo 1 , LFA 1 , and Leu M 5 in a dog with recurrent bacterial infections : an animal model . ^^^ Dogs with deficiency of leukocyte Mo 1 , LFA 1 , and Leu M 5 expression may represent a useful animal model to characterize further the molecular basis for an inherited disorder in leukocyte effector function . . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Third member of the LFA 1 / CR3 polypeptide family identified by anti Leu M 5 monoclonal antibody . ^^^ Sequential immunoprecipitation with anti p 95 beta chain mAb specifically removed the antigens detected by anti LFA 1 , anti CR 3 and anti Leu M 5 mAb . ^^^ Stimulation of normal granulocytes with f Met Leu Phe , C5a desArg , or calcium ionophore resulted in increased expression of Mo 1 and Leu M 5 antigens on the cell surface , but did not significantly increase expression of LFA 1 antigen . ^^^ These studies clearly indicate that the p150 / 95 antigen recognized by the anti Leu M 5 antibody is a structurally distinct member of the LFA 1 / CR3 family . . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
It was found that the MoAbs against LFA 1 ( CD11a ) , CD11c , LFA 3 ( CD 58 ) , ICAM 1 ( CD 54 ) or HLA DR could significantly suppress T cell proliferation in an allogeneic mixed lymphocyte reaction ( P < 0 . 05 ) , while being unable to inhibit clustering of BDC with T cells . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Adherence to rat pulmonary artery endothelial cells by human neutrophils and endothelial cell killing by phorbol ester activated human neutrophils required CD11b , CD11c , and CD 18 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The leukocyte integrins consist of a common CD 18 ( beta ) subunit and individual , noncovalently associated alpha subunits designated CD11a , CD11b , and CD11c . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
MoAb to CD11b , CD11c , and CD 18 each efficiently blocked ADCC by normal PMN . ^^^ Granulocyte macrophage colony stimulating factor ( GM CSF ) significantly increased the expression of CD11b , CD11c , and CD 18 on normal PMN , decreased the expression of Fc receptors ( FcR ) , and enhanced ADCC by normal but not by LAD PMN . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We found that MCP 1 induced expression of CD11c ( p 150 , 95 alpha subunit ) and CD11b ( Mac 1 alpha subunit ) , and caused little or no change of CD11a ( lymphocyte function associated Ag 1 alpha subunit ) , very late activation Ag 4 , or leukocyte adhesion molecule 1 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Northern blot analysis indicated the presence of CD11a , CD11c , and CD 18 mRNA in the AMs . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The expression of three alpha chains designed as CD11a , CD11b , CD11c , a common beta chain CD 18 , and of a ligand for several integrins CD 54 ( ICAM 1 ) was studied on alveolar macrophages of patients with active and inactive sarcoidosis and in control subjects . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The mean fluorescence intensity ( MFI ) of monocyte CD11a was enhanced by interleukin 2 ( IL 2 ) , TNF alpha and TNF beta , and that of CD11b , CD11c and CD 18 was increased by IL 2 , IL 4 , TNF alpha and TNF beta . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The beta 2 ( B 2 ) integrin ( leukocyte integrin , CD11 / CD18 ) subfamily comprising three members , each consisting of a shared beta subunit ( CD 18 ) non covalently associated with unique alpha subunits ( CD11a , CD11b , CD11c ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
These 6 included a new anti canine CD 18 mAb , 2 anti canine CD11a mAb , 2 anti canine CD11c mAb , and a mAb which recognizes a novel canine CD11 / CD18 related macrophage antigen , designated LeuCAMmac , which is described in a separate report . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
These nonphagocytic cells appear to be related to follicular dendritic cell ( FDC ) as they do not have properties of monocytic lineage cells or dendritic cells and because , like FDC , 1 ) they express CD11b , CD 14 , CD 29 , CD 40 , CD 54 , CD 73 , CD 74 , and VCAM 1 , and do not express CD11c , CD 22 , T cell markers , CD 18 , CD 25 and CD 45 ; and 2 ) they bind human B lymphocytes and B cell lines , but not T lymphocytes by an adhesion blocked in part by mAb to VLA 4 ( CD49d ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The adhesion and subsequent migration of freshly isolated NK cells was mainly mediated by CD11b / CD18 , because migration could be inhibited by 80 + / 8 % anti CD11b ( Mac 1 ) antibodies but not with antibodies against CD11a ( LFA 1 ) or CD11c ( p 150 , 95 ) , the other alpha chains of the beta 2 integrins . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
With this , we analyzed the phenotypes of CD34+ HSCs and showed that primitive HSCs or CD34+CD33 cells expressed adhesion molecules such as CD 43 , CD 44 , CD11a , CD11c , CD 18 , and leukocyte adhesion molecule ( LAM 1 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
CD11a ( LFA 1 ) and CD11b are less expressed , whereas CD11c is preserved . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Other molecules involved in cell / cell adhesion are LFA 1 ( CD11a / CD18 ) , Mac 1 ( CD11b / CD18 ) and their ligand ICAM 1 ( CD 54 ) , p 150 , 95 ( CD11c / CD18 ) , LFA 3 ( CD 58 ) , CD 44 , and LECAM 1 . ^^^ Thymic B cell lymphomas consistently lacked VLA 1 , 2 , 3 , 5 , 6 , and CD11b , expressed ICAM 1 in 21 of 23 cases but were heterogenous for VLA 4 , LFA 1 , CD11c , LFA 3 , CD 44 , and LECAM 1 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The HC were shown to express the integrin beta 1 subfamily molecules , LFA 1 ( CD11a ) and p 150 , 95 ( CD11c ) in high density but lacked CR 3 ( CD11b ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Differentiation of promyelocytic HL 60 cells along the pathway toward granulocytes using dimethyl sulfoxide ( DMSO ) led to increased expression of the adhesion molecules CD11b ( Mac 1 ) , CD11c ( p 150 , 95 ) , and CD 35 ( CR 1 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
By immunohistochemical staining , the cells were identified as macrophages due to expression of Mac 1 and p 150 , 95 ( CD11C ) Ag . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
CD11a ( LFA 1 ) was more expressed in NHL and IDL than in B CLL ( P = . 047 ) , although it was demonstrable in 74 . 2 % of cases ; CD11c was more expressed in B CLL ( P less than . 0001 ) , and its expression was preserved in almost all of the cases of small lymphocytic lymphoma . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The role of leucocyte integrins in phagocyte function has been studied by comparing normal neutrophils with those from a patient with partial leucocyte adhesion deficiency ( LAD ) , in whom the levels of CD11b and CD11c were 10 % of controls , whereas CD11a levels were normal . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
These markers include the arrest of cell proliferation , production of reactive oxygen species , changes in the cell surface expression of differentiation associated antigens such as the transferrin receptor , CD11b and CD11c and changes in the levels of several specific gene transcripts such as CD 18 antigen , c myc , ornithine decarboxylase and vimentin . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The expression of the adhesion molecules ( CD11a , b , c / CD18 ) of peritoneal neutrophils , which was determined by an immunofluorescence study , was about four times as much in CD11b and twice as much in CD11c and CD 18 compared to that in blood neutrophils . ^^^ The enhanced adherence activity of peritoneal neutrophils to tumor cells was significantly inhibited by pretreatment of the neutrophils with anti CD11b and anti CD 18 monoclonal antibodies ( mAb ) , but not by pretreatment with anti CD11a or anti CD11c mAb . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Components involved in superoxide anion production ( cytochrome b ) and in cell adhesion processes ( CD11b , CD11c , CD 18 ) , two early functional responses of neutrophils during acute inflammation , are intracellularly located in resting human neutrophils . ^^^ We have found a correlation between secretion of gelatinase and overexpression in the plasma membrane of CD11b , CD11c , CD 18 and cytochrome b upon cell activation . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
When the role of different a chains was studied , anti alpha L ( CD11a , LFA 1 ) , anti alpha M ( CD11b , Mac 1 ) and anti alpha 10 ( CD11c , p 150 , 95 ) caused marginal inhibition , but the effect of the 3 combined was comparable to that of anti CD 18 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
By modifying our microassay , we were able to assess PMN transmigration across T 84 monolayers in the physiological direction ( which , for technical reasons , has not been studied in epithelia ) : transmigration was again largely attenuated by MAb to CD 18 or CD11b ( 86 + / 2 % and 73 + / 3 % inhibition , respectively ) but was unaffected by MAb to CD11a , CD11c . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The three molecules consist of a specific alpha chain ( CD11a , CD11b , or CD11c ) and share a common beta chain ( CD 18 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Whereas expression of CD11b and CD11c is almost exclusively restricted to cells of the myeloid lineage , that of CD11a and CD 18 is panleukocytic . ^^^ Further analysis of this region of the CD11b gene and comparison with the promoters of the CD11a , CD11c , and CD 18 genes should lead to significant insights into the molecular mechanisms by which these genes are regulated during hematopoietic development and upon activation . . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Treatment of U 937 cells with PMA markedly increased CD 14 , CD11a , CD11b and CD 18 antigen expression , and slightly increased CD11c expression . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Monocyte adhesion induced by anti CD 14 mAb required neither Fcy gamma R engagement nor cross linking of CD 14 , because adhesion was induced by F ( ab ) ' 2 fragments , as well as by monovalent F ( ab ) fragments of anti CD 14 mAb . mAb to CD11a , CD 18 , and intercellular adhesion molecule 1 ( ICAM 1 ) , but not antibodies to CD11b and CD11c , inhibited monocyte adhesion induced by CD 14 engagement . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The overall molecular organization of this family of leukocyte integrins was similar to the human counterpart , and consisted of a common beta subunit of 95 kD ( CD 18 ) and non covalently linked alpha subunits of 150 kD ( CD11C ) , 165 kD ( CD11b ) and 180 kD ( Cd11a ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Adhesion was markedly inhibited by MAb against CD 18 and CD11b , with lesser or no inhibition being afforded by MAb against CD11a , CD11c , or ICAM 1 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The expression of CD11a , CD11b , CD11c , CD 15 , CD 18 , CD 10 , CD 24 and B 13 3 membrane antigens was also evaluated . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
CD11b , CD11c , CD 14 and CD 18 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
In particular , QE7 . 3E8 stains lymphoid tissue with a distribution clearly distinguishable from CD 18 antibodies ; it precipitates four bands from a T cell line which does not express the CD11b and CD11c alpha chains , and cross immunoprecipitation with QE7 . 3E8 and a CD11a antibody show that the molecules recognized by these antibodies are not associated . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The members of the LFA family of integrins , Mac 1 / Mo1 ( CD11 / CD18 ) and gp150 / 95 ( CD11c / CD18 ) , involved in adhesion of myeloid cells to endothelia and other substrates , were found to be overexpressed on the plasma membrane of neutrophils from patients undergoing hemodialysis with a Cuprophane dialyzer , whereas no change was observed in the expression of LFA 1 ( CD11a / CD18 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Preincubating AM with a monoclonal antibody to CD 18 reduced the adhesion of AM to MDCK cells by 40 % while a significant reduction could not be demonstrated after preincubation with antibodies to either CD11b or CD11c . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
However , chemotaxis in response to zymosan activated serum ( ZAS ) and f Met Leu Phe ( f MLP ) , was further impaired on the last day of treatment , which was associated with a marked increase in the expression of the granulocyte adhesion receptors CD11a ( P = 0 . 01 ) , CD11b ( P = 0 . 002 ) , CD11c ( P = 0 . 00015 ) and CD 18 ( P = 0 . 0014 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We have characterized the binding and phagocytosis of Hc yeasts by human PMN and quantified the PMN respiratory burst in response to this organism . mAb specific for CD11a , CD11b , and CD11c all partially blocked the attachment of unopsonized yeasts to PMN ; a mAb to CD 18 inhibited attachment by greater than 90 % . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Binding of labelled concanavalin A to membrane proteins which were separated by PAGE and transferred to nitrocellulose paper indicated that proteins with apparent molecular masses similar to those of CD11c ( 150 kDa ) and CD 18 ( 95 kDa ) molecules were the main concanavalin A binding proteins in differentiated U 937 cells as well as in mature neutrophils . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The distribution of leucocyte common antigen ( LCA ) protein subspecies and the cellular adhesion molecules LFA 1 ( CD11a ) , ICAM 1 ( CD 54 ) and p 150 , 95 ( CD11c ) has been established within frozen sections of human foetal thymus . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
In normal monocytes , CD 18 and CD11c are concentrated at specific adhesion sites , named podosomes , together with actin , vinculin , and talin , while CD11a , CD11b , CD29 / beta 1 , CDw49d / alpha 4 and CD54 / ICAM 1 retain a diffuse distribution on the cell surface without a selective pattern of localization . ^^^ Further , in these cells CD 18 , CD11a , CD11c , ICAM 1 , and talin , but not vinculin , co localize in homotypic cell junctions , thus showing a close relationship between integrins and talin . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Resting microglia were found to express constitutively CD11a ( LFA 1 ) , CD11b ( Mac 1 , CR 3 ) , CD11c ( P 150 , 95 ; CR 4 ) , and CD 18 ( beta 2 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Antibodies to either CD11a , CD11b or CD11c did not inhibit adhesion when used separately , whereas as a mixture their inhibitory capacity was as strong as that of anti CD 18 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Indeed , preincubation with antibodies to either CD 18 or CD11b , but not to CD11c , inhibited the oscillations of cytosolic free Ca2+ in adherent neutrophils . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
In contrast , mAb against the alpha subunits of Mac 1 ( CD11b ) and p150 . 95 ( CD11c ) were hardly effective . fMLP mediated neutrophil adhesion was reduced to below baseline levels by anti LeuCAM ( CD 18 ) mAb , whereas the LeuCAM contribution in IL 1 mediated neutrophil adhesion was less pronounced and varied in time . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The leukocyte cell adhesion receptors , complexes of the cluster of differentiation antigen 11a with cluster of differentiation antigen 18 ( CD11a / CD18 ) , cluster of differentiation antigen 11b with cluster of differentiation antigen 18 ( CD11b CD 18 ) and cluster of differentiation antigen 11c with cluster of differentiation antigen 18 ( CD11c CD 18 ) , are of major importance in several leukocyte functions . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Uninvolved keratinocytes were found to stain with anti CD 58 ( leucocyte function associated antigen 3 , LFA 3 ) and there was weak expression of CD11b ( alpha chain of complement C3bi receptor ) and CD11c ( alpha chain of p 150 , 95 molecule ) but not CD11a ( leucocyte function associated antigen 1 , LFA 1 , alpha chain ) on those cells . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Immunophenotypically , they are highly reactive for CD 4 , phagocytic receptors FcRI , 2 , and 3 , for HLA Dr and CD 31 , as well as for the integrins CD11a , CD11c , and CD 18 , but negative for CD 35 and transferrin receptor epitopes . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Few synovial lining cells expressed CD11a ( LFA 1 ) and CD11c ( p 150 , 95 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
One , 2E6 , bound a determinant common to all members of the CD11 / CD18 family , most likely the shared 90 kD CD 18 beta chain . 2E6 immunoprecipitated the characteristic beta 2 integrin heterodimers from lymphocytes ( p 180 , 90 ; CD11a ) and macrophages ( p 170 , 90 ; CD11b ) , but from dendritic cells , a p 150 , 90 ( presumably CD11c ) integrin was the predominant species . 2E6 inhibited the binding function of the CD11a and CD11b integrins on B cells and macrophages in appropriate assays , but 2E6 exerted little or no inhibition on the clustering of dendritic cells to T cells early in primary MLR , suggesting a CD11 / CD18 independent mechanism for this binding . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The leucocyte surface glycoproteins CD11a ( gp 160 , LFA 1 antigen , TA 1 antigen ) , CD11b ( gp 155 , Mac 1 antigen , OKM 1 antigen , Mo 1 antigen ) , CD11c ( gp 130 , Leu M 5 antigen ) , and CD 18 ( gp 90 ) constitute three heterodimers with different alpha chains and a common beta chain . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Antibodies to CD11a , CD11b , CD11c , CD 15 , CD 17 , CD 18 , and CD 45 do not activate monocytes . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The CD11 / CD18 family of leukocyte adhesion promoting proteins is comprised of three members , each composed of a shared beta subunit ( CD 18 ) noncovalently associated with unique alpha subunits ( CD11a , CD11b and CD11c respectively ) . ^^^ A vast series of immunostaining procedures was carried out , using monoclonal antibodies anti CD11a , CD11b , CD11c , and CD 18 . ^^^ The results demonstrated the expression on the membrane of Langerhans cells of the CD11b , CD11c and CD 18 antigens , thus indicating that at least both the H Mac 1 ( CD11b / CD18 ) and the gp 150 , 95 ( CD11c / CD18 ) members of the CD11 / CD18 family are detectable on the cell surface of human resting Langerhans cells . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
These antibodies immunoprecipitated pig proteins corresponding to the human alpha subunits of LFA 1 ( CD11a ) , Mac 1 ( CD11b ) and LeuM 5 ( CD11c ) , and their common beta subunit ( CD 18 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Pretreatment of lymphocytes with mAb to the accessory molecules CD 2 , CD 3 , CD 4 , CD 8 , CD11b , or CD11c did not interfere with their response to HD cells . mAb to CD11a ( LFA 1 ) , the alleged ligand of ICAM 1 , inhibited the ICAM 1 but not the HD lectin mediated lymphocyte stimulation . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Inhibition of PMN attachment to IL 1 activated HEC was measured in a quantitative in vitro monolayer adhesion assay , after treatment with mAb directed to ELAM 1 ( mAb H18 / 17 ) , and to CD11a ( mAb L 11 ) , CD11b ( mAb 44 ) , CD11c ( mAb L 29 ) , and CD 18 ( mAb 10F12 ) , alone or in combination . ^^^ At this time , CD11 / CD18 dependent adhesive mechanisms predominated and a CD11c dependent mechanism became apparent ( anti CD11a , 67 + / 4 % inhibition ; anti CD11b , 45 + / 9 % ; anti CD11c , 26 + / 6 % ; anti CD 18 , 97 + / 1 % ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We focused on the E / T interaction of opsonized cells in the presence of anti CD 18 mAb . mAb directed to the CD11a molecule caused 0 to 30 % inhibition of the lysis of both non opsonized and opsonized cells whereas the mAb antibody directed to the CD11c molecule had no effect . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
A small component of phosphothreonine was present in CD11c and CD 18 and a minor component of phosphotyrosine was also detected in CD 18 upon leukocyte activation may regulate the adhesion functions mediated by the CD11 / CD18 family of molecules . . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies against CD 2 , CD 4 , CD11a , CD 18 , LFA 3 , ICAM 1 , class 1 and class 2 major histocompatibility complex ( MHC ) inhibited T cell proliferation in this response , whereas antibodies against CD 8 , CD11b , CD11c and CD 16 had no effect . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
HC commonly expressed the CD11a , CR 4 ( CD11c ) , CD 15 , CD 18 and a number of activation antigens but did not stain with a variety of macrophage specific antibodies . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
To determine the individual roles of CD11a / CD18 ( LFA 1 ) , CD11b / CD18 ( CR 3 , Mac 1 ) and CD11c / CD18 ( p 150 , 95 ) in adhesion of PDB stimulated PMN to unstimulated EC , mAb against the CD 11 chains were used . mAb against CD11a or CD11b each blocked adhesion of PMN to EC by approximately 50 % , but mAb against CD11c had no effect . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The aggregation of the two types of cell was blocked effectively by the addition of monoclonal antibodies to the alpha and beta chains ( CD11a , CD 18 ) of lymphocyte function associated antigen ( LFA ) , but not by monoclonal antibodies to LFA 3 and the alpha chain of p 150 , 95 ( CD11c ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The acquisition of monocyte cytotoxicity was associated with nearly a twofold increase in surface expression of three CD 18 bearing cell surface molecules ( CD11a , CD11b , CD11c ) . ^^^ The inhibition by anti CD 18 MAb could not be attributed to LFA 1 ( CD11a ) alone , suggesting that CR 3 ( CD11b ) and p 150 , 95 ( CD11c ) may also participate in monocyte mediated cytotoxicity . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Primed T cells become independent of the blocking effects of monoclonal antibodies against IL 1 beta and the CD 5 , CD11a ( LFA 1 ) , and CD11c ( p 150 , 95 ) molecules . ^^^ We have compared the requirements of the primary MLR and the responses of alloreactive , primed lymphocytes ( PL ) by inhibition studies using monoclonal antibodies ( MoAb ) directed against ( 1 ) adhesion molecules belonging to the CD 11 cluster of leucocyte antigens ( CD11a , LFA 1 ; CD11b , MAC 1 = CR 3 ; and CD11c , p 150 , 95 ) ; ( 2 ) various T cell related antigens ( CD 2 , CD 4 , CD 5 and CD 8 ) ; and ( 3 ) recombinant IL 1 beta . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Previous investigations of p 150 , 95 ( CD11c ) , the third member of the CD 18 membrane glycoprotein family that includes CR 3 ( Mac 1 or CD11b ) and LFA 1 ( CD11a ) , had demonstrated that solubilized p 150 , 95 bound to iC3b agarose in a manner similar to isolated CR 3 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
To assess the possible in vivo significance of these observations we studied the effect of GM CSF on CD11b , CD11a ( LFA 1 ) , and CD11c ( gp 150 , 95 ) expression on granulocytes from nine adult patients with sarcoma who were receiving GM CSF as part of a phase 1 trial . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Whereas noninfected U 937 cells expressed moderate amounts of lymphocyte function associated antigen 1 ( LFA 1 ) ( CD11a ) and minimal amounts of the C3bi receptor ( CD11b ) and p150 / 95 ( CD11c ) , U937 / HIV cells expressed moderate amounts of C3bi receptor and p150 / 95 and showed elevated expression of LFA 1 alpha ( CD11a ) and beta ( CD 18 ) chains . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Stimulation of human neutrophils by the chemoattractant formyl methionyl leucyl phenylalanine or the calcium ionophore A 23187 induced increments in the cell surface expression of the alpha subunits of Mo 1 ( CD11b ) and gp 150 , 95 ( CD11c ) and their common beta subunit ( CD 18 ) . ^^^ By subcellular fractionation and immunoprecipitation studies , we have found that CD11b , CD11c and CD 18 molecules were mainly localized in the membranes of tertiary granules , which were resolved from the specific and azurophilic granules as well as from the plasma membrane fraction . . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
This antibody recognizes GP 90 ( CD 18 ) , a leukocyte surface glycoprotein which is separately and noncovalently associated to either GP 160 ( CD11a ) , GP 155 ( CD11b ) , or GP 130 ( CD11c ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Flow cytometric analysis demonstrated that monocytes stimulated with 500 U / ml rIFN gamma for 24 h showed increased expression of CR 3 ( CD11b / CD18 ) , p 150 , 95 ( CD11c / CD18 ) and Fc gamma RI ( CD 64 ) ; the expression of LFA 1 ( CD11a / CD18 ) , L selectin , CD 14 and VLA 4 ( CD49d / CD29 ) did not change or was slightly reduced . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
This effect appeared to be restricted to CD11b ( CR 3 ) and CD11c ( gp 150 95 ) , because CD11a ( LFA 1 alpha chain ) was not modified . beta 2 Adrenoceptor stimulation was also found to potentiate the effect of IL 4 on CD11b , CD11c , and CD 18 expression . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The density ( expressed as mean fluorescence intensity ) of CD11b on monocytes and polymorphs was increased ( P < 0 . 005 ) , as was CD11c ( P < 0 . 005 ) and CD 18 ( P < 0 . 05 ) on polymorphs . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
All three chemokines tested induced increased expression of the alpha chains of two members of beta 2 family of integrins , CD11b and CD11c , and their common beta chain ( CD 18 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Triggering via CD 40 using NIH3T3 CD 40 ligand transfectant ( CD40LT ) cells increased ( > 30 % ) cell surface CD 80 , CD 18 , CD11a , CD11b , and CD11c expression on MM cell lines . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Certain antibodies directed against CD 18 , CD11b and CD11c inhibited HIV 1 induced syncytium formation but not entry , in agreement with previous reports . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
For the beta 2 integrin subfamily , the cell surface density was increased for CD 18 and CD11a , while the CD11c molecule was expressed exclusively on the HTLV 1 and HTLV 2 infected cell lines . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
This study examined the relationship between exercise induced changes in the concentration of circulating immunocompetent cells and their surface expression of adhesion molecules : L selectin ( CD62L ) and three beta 2 integrins [ LFA 1 ( CD11a / CD18 ) , Mac 1 ( CD11b / CD18 ) , and p150 / 95 ( CD11c / CD18 ) ] . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We show that IFN beta downregulates both basal and IFN gamma induced expression of VLA 4 ( very late activation antigen 4 ) antigen on monocytes , but has no effect on the expression of CD11a , CD11b , CD11c , L selectin , CD 18 , ICAM 1 , beta 1 integrin or CD 44 on monocytes or ICAM 1 on EAhy 926 cells . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Hematopoietic cell type dependent regulation of leukocyte integrin functional activity : CD11b and CD11c expression inhibits LFA 1 dependent aggregation of differentiated U 937 cells . ^^^ These results confirm the role of CD11b / CD18 and CD11c / CD18 in myeloid cell adhesion and spreading and suggest that the CD11b / and CD11c / CD18 mediated recognition of substrate bound ligands competes or interferes with LFA 1 dependent intercellular adhesion . . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
During transdifferentiation , expression of CD11c was present for only 3 days and that of CD 18 , for only 7 days . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Intracellular calcium content was monitored in real time with the calcium indicator , indo 1 , after cross linking Fc gamma RI , Fc gamma RII , CD11b , CD11c , or CD 18 molecules , or addition of interleukin 1 alpha , IL 1 beta , interferon gamma , bradykinin , substance P , or FMLP . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
CMC were not recognized by MoAbs to lymphocyte function associated antigen 2 ( LFA 2 ; CD 2 ) , T cell receptor ( TcR ; CD 3 ) , T 4 antigen ( CD 4 ) , LFA 1 alpha chain ( CD11a ) , C3biR alpha chain ( CD11b ) , CR 4 alpha chain ( CD11c ) , LPS R related Ag ( CD 14 ) , 3 FAL / x hapten ( CD 15 ) , Fc gamma RIII ( CD 16 ) , lactosylceramid ( CDw 17 ) , the B cell antigen CD 19 , or CR 1 ( CD 35 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Normal blood basophils and KU 812 cells were found to express C5aR ( CD 88 ) , membrane cofactor protein ( CD 46 ) , decay accelerating factor ( CD 55 ) , and membrane attack complex inhibitory factor ( CD 59 ) , as well as the previously recognized CR 1 ( CD 35 ) , CR 3 alpha ( CD11b ) , CR 4 alpha ( CD11c ) , and CR3 / 4 beta ( CD 18 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The beta 2 integrins are composed of a common 95 kD beta subunit ( CD 18 ) and one of three possible alpha subunits : CD11a , CD11b , or CD11c . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Immunohistochemistry showed that BDC were strongly positive for antibodies against HLA DR , CD11c , CD 18 , CD 44 and CD 54 , and moderately positive for anti CD11a , CD 31 , CD 43 and CD 58 . ^^^ Preincubation of HUVEC with antibodies against E selectin ( 10 micrograms / ml ) significantly inhibited ( P < 0 . 02 ) the binding of radiolabelled BDC to activated HUVEC ( 32 . 2 + / 1 . 3 % ) whereas preincubation of BDC with antibodies against CD 54 , CD 18 , CD11b , CD11c and Sialyl Lewis 10 did not produce any significant inhibition . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Treatment of leukocytes with phorbol myristate acetate ( PMA ) caused significant increases in the expression of adhesion molecules , CD11a , CD11b , CD11c , and CD 18 , on the surface of the leukocytes . ^^^ Both the early increase in peroxide production and late cell lysis were abolished by specific antibodies against CD11a , CD11b , CD 18 , and ICAM 1 , but not CD11c . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
According to previous findings , basophils express CD 9 ( p 24 ) , CD11a ( LFA 1 alpha chain ) , CD11b ( C3biR ) , CD11c ( CR 4 ) , CD 13 ( aminopeptidase N ) , CDw 17 ( lactosylceramide ) , CD 18 ( beta chain of beta 2 ) , CD 25 ( IL 2R alpha chain ) , CD 26 ( dipeptidylpeptidase ) , CD 31 ( PECAM ) , CD 35 ( CR 1 ) , CD 38 ( T 10 ) , CD 43 ( leukosialin ) , CD 44 ( Pgp 1 ) , CD 45 ( pan leukocyte Ag ) , and CD 63 ( basophil activation Ag ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The expression of adhesion molecules in vitro was differential : the number of cells carrying CD11c , CD 29 , CDw49b , CDw49d , CDw49e , CDw49f , CD 54 , CD 56 and ELAM 1 being significantly overrepresented among the nickel induced lymphoblasts whereas the number of blasts carrying CD 44 was underrepresented and those of CD11a , CD 18 , CD 58 and LAM 1 remained unchanged . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
In addition , these cells were weakly positive for CD11b ( Mac 1 ) and CD 54 ( ICAM 1 ) , but were negative for lymphocyte specific CD11a ( LFA 1 ) and CD11c ( p 150 , 95 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The beta subunit gene ( CD 18 ) is constitutively expressed on all leukocytes , however , the alpha subunit genes for LFA 1 , Mac 1 and p 150 , 95 ( CD11a , CD11b and CD11c , respectively ) show cell and developmental stage specific expression . ^^^ The half life of CD11c MRNA in differentiated HL 60 cells was not unusually long and similar to that of CD 18 mRNA found in both undifferentiated and differentiated cells which suggested that altered mRNA stability did not account for the appearance of CD11c mRNA . ^^^ Inhibition of protein synthesis in differentiated HL 60 cells did not lead to significant changes in the steady state levels of either CD11c or CD 18 mRNAs . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Since CD 18 is expressed on all leukocyte lineages , the restricted expression of p 150 , 95 must be controlled at the level of CD11c gene transcription . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The percentage of BAL lymphocytes showed a relationship with the expression of macrophage antigens in 11 out of 15 antigens studied ( all except adhesive molecules CD11a , CD11c , CD 18 and the antigen 25F9 present on mature macrophages ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Neutrophil integrin expression ( CD 18 , CD11a , CD11c ) , aggregation , and transendothelial migration were studied in vitro . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
CD11a , CD11b , CD11c , CD 18 , CD49b , and CD49f failed to demonstrate any immunostaining with type 2 cells . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We tested fluorometrically the expression of neutrophil membrane molecules ( CD11b , CD11c , CD 18 ) and neutrophil oxidative burst using a chemiluminescence ( CL ) generation system . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The mean fluorescence of CD 18 on lymphocytes and CD11c on monocytes of HIV 1 infected subjects was significantly higher than for the control group ( P = . 008 and . 014 , respectively ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The leukocyte integrins consist of a common beta 2 chain ( CD 18 ) covalently linked to one of three different alpha chains ( CD11a , CD11b , CD11c ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Now , data which reveal that exposure of HL 60 cells to this factor also brings about an increase in the mean level of surface expression of CD11c , the alpha chain of another leukocyte integrin ( p 150 , 95 ) , but leaves CD11a , the alpha chain of the third leukointegrin ( LFA 1 ) , virtually unchanged ( < 10 % ) are presented . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Surface expression of the beta 2 integrin chains ( CD11a , CD11b , CD11c and CD 18 ) , and the beta 1 integrin chains ( CD49b , CD49d , CD49f and CD 29 ) , as well as that of members of the immunoglobulin superfamily ( CD 2 , CD 54 , CD 56 and CD 58 ) , were analyzed by one or two color flow cytometry . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
During the third trimester fetal expression of CD 18 , CD11b , and CD11c on neutrophils and CD11b on monocytes was lower , and maternal expression of CD11a on neutrophils and CD 18 , CD11a and CD11c on monocytes was higher than were the control adult values . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Spreading was inhibited by the addition of antibodies against CD 18 or CD11c . ^^^ Culturing in the presence of prednisolone resulted in an inhibition of spreading , most likely mediated via a down regulation of CD 18 and CD11c expression . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Like IL 4 , it enhanced the expression of CD11b , CD11c , CD 18 , CD 29 , CD49e ( VLA 5 ) , class 2 MHC , CD 13 , and CD 23 , whereas it decreased the expression of CD 64 , CD 32 , CD 16 , and CD 14 in a dose dependent manner . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Because leukocyte integrin expression on PMNs affects transendothelial migration , we also compared surface expression of CD 18 , CD11a , and CD11c on PMNs from the two age groups . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Surface expression of the beta 2 integrin chains ( CD 18 , CD11a , CD11b , CD11c ) , as well as that of members of the immunoglobulin superfamily ( CD 2 , CD 54 , CD 56 , CD 58 ) , were analysed by one or two colour flow cytometry . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
PIF has no significant inhibitory effect on staining of CR 1 ( CD 35 ) , CR 2 , ( CD 21 ) , 20 kDa homologous restriction factor ( CD 59 ) , decay accelerating factor ( CD 55 ) , LFA 1 ( CD11a ) , or p150 . 95 ( CD11c ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The effects of the cytokine tumour necrosis factor alpha and the calcium ionophore A 23187 upon CD11a , CD11b , CD11c and CD 18 leucocyte membrane expression was analysed in whole blood using monoclonal antibodies and flow cytometry . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The expression of the Leu CAM proteins ( CD11a , CD11b , CD11c , CD 18 ) was also evaluated during the culture period . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Expression of LeuCAM on freshly isolated cells was studied using the peroxidase antiperoxidase method with monoclonal antibodies ( MoAb ) detecting CD11a , CD11b , CD11c , and CD 18 . ^^^ Compared with nonsmokers , the samples from SA and IPF patients contained an increased number of AM expressing CD11a , CD11b , CD11c , and CD 18 ( all p < 0 . 008 ) , which was correlated to the number of AM / ml BAL ( p < 0 . 008 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Sodium dodecyl sulfate polyacrylamide gel electrophoresis of immunoprecipitates obtained from lysates of 125I labeled macrophages with rabbit polyclonal antibodies against the CD11a c / CD18 complex or against CD 18 , revealed four radioactive bands corresponding to CD11a , CD11b , CD11c , and CD 18 . ^^^ Monoclonal antibodies against CD11b and CD 18 inhibited by 80 and 90 % , respectively , the oxidative burst activation of the macrophages by type 1 fimbriated Escherichia coli , whereas monoclonal antibodies against CD11a , CD11c , and CD 43 were without effect . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Human lymphocyte function associated antigen 1 ( LFA 1 , CD11a / CD18 , alpha L / beta 2 ) is a cell surface heterodimer , which , together with Mac 1 ( CD11b / CD18 , alpha M / beta 2 ) and p 150 , 95 ( CD11c / CD18 , alpha X / beta 2 ) , constitutes the leukocyte integrin beta 2 ( CD 18 ) subfamily . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Cell surface marker analysis revealed that the cells were CD 4 , CD11a , CD11c , CD 13 , CD 14 , CD 18 , CD 33 , and HLA DR positive . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
It is LFA 1 dependent because CD11a and CD 18 mAbs inhibit homotypic aggregation , whereas CD11b and CD11c mAbs do not . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
With regard to the integrin family , monocytes expressed beta 1 ( CD 29 ) , alpha 4 , alpha 5 , alpha 6 , beta 2 ( CD 18 ) , CD11a , CD11b , and CD11c subunits , but not alpha 5 ( CD 51 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Except for CD11b , all other leukocyte integrins examined ( CD11a , CD11c and CD 18 ) and their ligand ( CD 54 ) were highly expressed in non CLL cases . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Expression of LeuCAM on freshly isolated cells was studied using a sensitive peroxidase antiperoxidase method with monoclonal antibodies ( mAB ) against CD11a , CD11b , CD11c , and CD 18 . ^^^ Compared with nonsmoker AM , significantly more AM from smokers expressed CD11b ( p < 0 . 001 ) , CD11c ( p < 0 . 001 ) , CD 18 ( p < 0 . 001 ) , and CD11a ( p < 0 . 004 ) , whereas there was no difference in the expression of other common epitopes of human macrophages such as CD 68 , CD 71 , CD 45 , HLA DQ , and HLA DR . ^^^ The number of AM expressing CD11a , CD11c , and CD 18 showed a correlation to the total number of AM obtained by BAL ( p < 0 . 001 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Murine monoclonal anti human antibodies directed against neutrophil adhesion protein receptors CD 35 , CD 18 , CD11b , CD11c and the Fc receptors CD 64 ( Fc gamma RI ) , CD 32 ( FC gamma RII ) and CD 16 ( Fc gamma RIII ) were evaluated regarding their ability to bind to the canine homologues . ^^^ The antibodies against CD 35 , CD 18 , CD11b , CD11c and CD 16 could be used to evaluate the expression of canine homologues . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
In this study we report the expression of adhesion molecules ( CD11a , CD11c , CD 18 and ICAM 1 ) , lymphocyte surface markers ( CD 3 , CD 4 , CD 8 and CD 22 ) and HLA DR molecules in 25 epiretinal membranes obtained from eyes undergoing vitrectomy for the treatment of retinal detachment complicated by epiretinal membrane formation . ^^^ The results showed that cells expressing the adhesion molecules CD11a , CD11c and CD 18 were present in 5 of 25 , 17 of 25 and 11 of 23 membranes , respectively . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We found epidermal CD1a+ Langerhans cells significantly decreased in pemphigus foliaceus compared to pemphigus vulgaris , but pemphigus foliaceus and not pemphigus vulgaris epidermis harbored large amounts of bone marrow derived ( CD45+ ) cells that expressed CD 68 , HLA DR , and beta 2 integrin antigens , the most pronounced expression being observed for CD11c and CD 18 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Those in zone B were distinguished by their dendritic morphology and strong reactivity with MoAbs directed against class 2 molecules , FcRI ( CD 64 ) and CD 68 , whereas macrophages in zone C were larger , more heterogeneous in shape , and were distinguished by strong reactivity with MoAbs directed against CR 4 ( CD11c , CD 18 ) and MRP8 / MRP14 , and with MoAb 24 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Identification of Sp 1 binding sites in the CD11c ( p 150 , 95 alpha ) and CD11a ( LFA 1 alpha ) integrin subunit promoters and their involvement in the tissue specific expression of CD11c . ^^^ The leukocyte integrins LFA 1 ( CD11a / CD18 ) and p 150 , 95 ( CD11c / CD18 ) mediate cell cell and cell extracellular matrix interactions during inflammatory responses and signal transduction into the cytoplasm . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The expression of molecules of the beta 2 integrin family ( CD11a , CD11b , CD11c , and CD 18 ) was explored on 2 human megakaryocytic cell lines and on platelets from different donors by immunofluorescence and flow cytometry using a large panel of mAb . ^^^ CD11a , CD11b , CD11c and CD 18 were detected on the megakaryocytic cell lines DAMI and HEL . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Despite extensive research in this field , only three members of this integrin subfamily have been described : CD11a / CD18 ( LFA 1 ) , CD11b / CD18 ( Mac 1 ) , and CD11c / CD18 ( p 150 , 95 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
In contrast , CD 18 ( beta 2 integrin ) , CD 61 ( beta 3 integrin ) , ICAM 2 , CD11a , CD11b and CD11c were all absent from these cells . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Whereas CD11a was increased only on monocytes , CD11b , CD11c , and CD 18 were strongly enhanced on monocytes and polymorphonuclear cells ( PMNs ) after treatment with MDPs . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We examined the expression of adhesion molecules of the integrin family ( CDw49b , CDw49d , CDw49e , CDw49f , CD 18 , CD11a CD11c , and CD11b ) , the immunoglobulin superfamily ( CD 54 , CD 56 , CD 58 , and CD 31 ) , the selectin family ( ELAM 1 , LECAM 1 , and CD 62 ) , and CD 44 , CD41b , and CD42b on platelets , megakaryocytes , and megakaryocytes with CP . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
In a retrospective study based on 107 B CLL patients , the expression of the adhesion molecules CD 44 , CD11a , CD11b , CD11c , CD 18 , CD 25 and CD 54 was analysed in bone marrow cryostat sections by immunohistochemistry . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
When the reactivity of mNI 11 and mAbs binding human differentiation antigens such as CD11a , CD11b , CD11c , CD 14 , CD 16 , CD 18 , CD 23 , CD 28 , CD 29 , CD 31 , CD 43 , CD 44 , CD45RA , CD49d , CD 50 , CD 54 , CD 58 , CD 80 , CD 102 , CD 106 , HLA class 1 , or HLA class 2 antigen was compared , no mNI 11 reactivity resembling that of these mAbs was found . mNI 11 markedly induced homotypic cell aggregation of U 937 cells when they were stimulated with LPS . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Infiltrating mononuclear cells expressed CD11a ( 68 % ) , CD 18 ( 73 % ) , CD11b ( 13 % ) , CD11c ( 21 % ) , CD 58 ( 13 % ) , CD 4 ( 44 % ) , CD 8 ( 17 % ) , CD62L ( L selectin ) ( 18 % ) , CD49d ( 38 % ) , CD49e ( 15 % ) , CD 2 ( 56 % ) , and CD 44 ( 77 % ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Soluble CD 16 bound to CR 3 ( CDllb / CD18 ) and CR 4 ( CDllc / CD18 ) positive leukocytes and cell lines , the labeling was inhibited by anti CD11b , CD11c or CD 18 mAbs , and the up regulation of CR 3 and CR 4 led to an increased fixation of sCD 16 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The resultant low density cell fraction consisted of a nonadherent cell population expressing different intensities of CD11c that could at least be characterized by typical DC morphology ( e . g . abundant cytoplasma with veil like cytoplasmatic dendrites , irregularly shaped nuclei , multivesicular and multilamellar bodies ) , constitutive levels of surface MHC class 2 , the presence of macrophage specific markers , such as F4 / 80 , Mac 1 and Fc receptors , respectively , on subpopulations of CD11c+ sorted cells and expression of adhesion and co stimulatory receptors like ICAM 1 and CD 44 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Surface expression of LFA 1 , Mac 1 , p 150 , 95 , and VLA 4 on neutrophils , lymphocytes , and monocytes was measured by fluorescent antibody cell sorting with monoclonal antibodies against CD11a , CD11b , CD11c , CD 18 , CD49d , and CD 29 respectively . ^^^ We tested the hypothesis that the expression of the beta 1 chain integrin VLA 4 ( CD49d / CD29 ) and the beta 2 chain integrins LFA 1 ( CD11a / CD18 ) , Mac 1 ( CD11a / CD18 ) , and gp 150 , 95 ( CD11c / CD18 ) is increased on leukocytes in patients with active WG . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Immunohistochemistry was performed for CD 18 , CD11a , CD11b , CD11c , alpha d , ICAM 1 , ICAM 2 , and ICAM 3 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
No significant changes in the cell surface expression of adhesion molecules CD11a , CD11b , CD11c , CD 18 , CD 54 , CD 44 , CD49d ( alpha 4 integrin ) and CD62L ( L selectin ) were observed on MV infected monocytes . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The expression of CD 18 , CD11a , CD11b and CD11c on the surface of polymorphonuclear leukocytes was examined by flow cytometry with monoclonal antibodies . ^^^ OBJECTIVES : This study evaluated the role of neutrophil adhesion molecules LFA 1 ( CD11a / CD18 ) , Mac 1 ( CD11b / CD18 ) and p 150 , 95 ( CD11c / CD18 ) in patients undergoing percutaneous transluminal coronary angioplasty ( PTCA ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
When the reactive patterns between mNI 58A and the mAbs to various human differentiation antigens ( CD11a , CD11b , CD11c , CD 14 , CD 16 , CD 18 , CD 23 , CD 28 , CD 29 , CD 31 , CD 43 , CD 44 , CD45RA , CD 50 , CD 54 , CD 58 , CD 80 , CD 102 , CD 106 , HLA class 1 and class 2 antigen ) were compared , that of mNI 58A was found to be similar to those of the leukocyte function associated antigen 1 ( LFA 1 ) mAbs . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Both the early and the late events were abolished in the presence of specific antibodies against CD ( cluster of differentiation ) 11a , CD11b , CD 18 and ICAM ( intercellular adhesion molecule ) 1 , but not CD11c . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Differential leukocyte count was performed on cytospin preparations and the expression of integrin alpha ( CD11a , CD11b , CD11c ) and beta ( CD 18 ) chains was assessed on granulocytes and mononuclear cells by immunocytology . ^^^ The numbers of neutrophils expressing CD11b and CD 18 , but not CD11c or CD11a , were increased in the subjects with airway obstruction compared with those without airway obstruction . ^^^ No significant correlations were found between CD11a , CD11b , CD11c , CD 18 positive mononuclear cells and lung function measurements . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Treatment of Dex induced monocytes with antibodies against RM3 / 1 , CD11a , CD11b , CD11c , CD 14 and CD 18 resulted in suppression of adhesion to stimulated HUVEC by 46 % , 18 % , 17 % , 12 % , 25 % and 15 % , respectively . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The expression of surface adhesion molecules on granulocytes , monocytes ( CD11a , CD11b , CD11c , CD 18 , L selectin ) , and platelets ( P selectin , gpIIb IIIa ) was determined after incubation with different graft surfaces [ expanded polytetrafluoroethylene ( ePTFE ) or woven Dacron ] . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
No changes in HLA DR or in other adhesion protein ( CD11a , CD11c , CD 18 , CD 54 ) expression were detected , and levels were similar in both patients and normal controls . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Comparable expression of CD 18 , CD11a , CD11b , and CD11c could be detected by immunofluorescence in leukocytes from samples drawn from either arm before tourniquet application . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Treatment with retinoic acid ( RA , 1 microM ) or 1 , 250 ( OH ) 2 vitamin D 3 ( 1 , 25 D 3 , 10 nM ) increased the expression of the monocytic surface antigens CD11b plus CD11c , and CD11b , CD11c , CD 14 plus CD 18 , respectively . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
When the reactivity of mNKES and mouse mAbs recognizing the human adhesion associated antigen ( CD 10 , CD11a , CD11b , CD11c , CD 14 , CD 16 , CD 18 , CD 23 , CD 28 , CD 29 , CD 31 , CD 43 , CD 44 , CD45RA , CD 50 , CD 54 , CD 58 , CD 80 , CD 102 , CD 106 , and HLA class 1 , and HLA class 2 antigen ) with various cell lines was compared , mNKES reactivity was found to be unique , not resembling that of any of these mouse mAbs . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Among the beta 2 integrins , the levels of Mac 1 ( CD11b ) and p150 . 25 ( CD11c ) were positive , while LFA 1 ( CD11a ) was not detectable . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The HMC 1 cells clearly expressed CD11a , CD 18 and CD 54 , while expression of CD11b and CD11c was low . ^^^ Phorbol myristate acetate ( PMA ) induced a time and dose dependent up regulation of CD11a , CD11b , CD11c , CD 18 and CD 54 that was inhibited by cycloheximide , suggesting a dependence on de novo protein synthesis . ^^^ Enhanced expression of CD11a , CD11b , CD11c and CD 18 could also be confirmed at the gene level as demonstrated by semi quantitative reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ Only LTB 4 was shown specifically to up regulate CD11a and CD 18 , but not CD11b or CD11c . ^^^ The presence of CD11a , CD11c and CD 18 could be confirmed on a low percentage of normal skin mast cells by immunofluorescence , using a double staining technique . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Exposure of NK cells to IL 2 and IL 12 augmented their adhesive ability , while IL 4 had an inhibitory effect . mAb directed against CD 18 and CD11a inhibited binding and migration of NK cells across resting or IL 1 activated EC , whereas anti CD11b and Cd11c did not . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
However , adhesion to myeloperoxidase was inhibited by monoclonal antibodies to alpha M ( CD11b ) or to beta 2 ( CD 18 ) integrin subunits , but not by antibodies to alpha L ( CD11a ) , alpha M ( CD11c ) , or to other integrins . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Granulocyte and monocyte surface adhesion molecule expression was determined indirectly using a panel of monoclonal antibodies against CD11a , CD11b , CD11c , CD 18 , and L selectin in donor white blood cells exposed to patient plasma . ^^^ CD11b , CD11c , and CD 18 molecules on both granulocytes and monocytes were significantly upregulated 60 minutes after the endovascular procedure compared to conventional surgery . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Surface expression of integrins was measured by FACS analysis in 19 healthy subjects ( 16 males , 3 females , 36 . 6 + / 8 . 7 years , 177 . 1 + / 7 . 5 cm , 70 . 3 + / 8 . 1 kg ) before and after submaximal exercise ( 3 h run ) using monoclonal antibodies against cd11a , cd11b , cd11c , cd 18 , cd 29 and cd 49 . ^^^ Nevertheless , the expression ( indicated by the mean log fluorescence ) of cd11a ( 94 + / 24 vs . 78 + / 14 ) and cd 18 ( 128 + / 31 vs . 102 + / 21 ) on lymphocytes and of cd11a ( 104 + / 25 vs . 85 + / 16 ) , cd11c ( 497 + / 171 vs . 408 + / 126 ) cd 29 ( 109 + / 16 vs . 89 + / 16 ) , cd 49 ( 69 + / 8 vs . 54 + / 11 ) on monocytes was decreased after exercise ( all P < 0 . 05 ) . ^^^ Since leucocyte adhesion is mediated by integrins , we tested the hypothesis that surface expression of the integrin adhesive receptors LFA 1 ( cd11a / cd18 ) , MAC 1 ( cd11b / cd18 ) , gp 150 / 95 ( cd11c / cd18 ) , and VLA 4 ( cd29 / cd49 ) is decreased by moderate endurance exercise . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
A panel of monoclonal antibodies against CD11a , CD11b , CD11c , CD 18 and L selectin was used . ^^^ RESULTS : The expression of CD11a adhesion molecules only showed slight variations regarding granulocytes , but was more pronounced on monocytes , however , without significant differences between the two patient groups , CD11b , CD11c and CD 18 molecules on both granulocytes and monocytes were significantly upregulated 60 min after the endovascular procedure compared to conventional aneurysm repair , and L selectin molecules were by this time correspondingly cleaved off . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The inhibitory action of PU . 1 on CD11c is in contrast with its positive regulatory effect on the CD11b and CD 18 integrin gene promoters , which might contribute to the differentially regulated expression of CD11b / CD18 and CD11c / CD18 during monocyte extravasation and terminal maturation . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Using mAbs directed against human CD 14 and components of the human LFA 1 complex , we identified coelomocyte surface antigens cross reactive with CD 14 , CD11b and CD11c . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
On alveolar macrophages obtained after the release of aortic cross clamp , macrophages as compared with alveolar macrophages obtained before cardiopulmonary bypass , there was a significant enhancement of CD11a , CD11b , CD11c , and CD 18 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The effects of linoleic acid , linoleic acid anilide , and arachidonic acid on the expression of CD11b / CD 18 , CD11c / CD18 integrins and L selectin on human neutrophils were studied by flow cytometry in a whole blood assay . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Splenic Mphi and DC were purified by sorting on the basis of Mac 1 and CD11c expression and stimulated with LPS or Chinese hamster ovary cells expressing CD40L . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Expressions of CD11b , CD 18 and CD 54 , but not CD11a or CD11c , were higher on monocytes freshly isolated by density gradient separation and plastic adherence as compared with cells labelled directly in whole blood . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Increased adhesiveness was not associated with an abnormal expression of CD11a , CD11b , CD11c , CD 18 , CD62L , or CD 15 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We have studied the post injury expression of the lymphocyte , monocyte and neutrophil adhesion molecules CD11a ( LFA 1 ) , CD11b , CD11c , CD 29 ( beta 1 integrin ) and CD62L ( L selectin ) in a group of 36 trauma patients , 13 of whom had suffered major trauma ( ISS > or = 16 ) , 15 moderate trauma ( ISS = 9 15 ) and eight minor trauma ( ISS < 9 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Moreover , several integrins ( CD11b , CD11c , CD 18 , CD41a , CD 61 and CD 29 ) were also found . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Immunohistochemistry was performed for CD 18 , CD11a , CD11b , CD11c , alphad , ICAM 1 , ICAM 2 , and ICAM 3 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Previous studies have shown that triggering multiple myeloma ( MM ) cells via CD 40 induces IL 6 mediated autocrine growth as well as increased expression of cell surface adhesion molecules including CD11a , CD11b , CD11c , and CD 18 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The expression of CAM was analyzed by flow cytometry using monoclonal antibodies against CD49d , CD 29 , CD11a , CD11b , CD11c , CD 18 , CD62L , CD 54 and CD 44 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The expression of CD11b , CD11c , and CD 18 on human neutrophils after G CSF treatment increased , but CD11a did not . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Third , maturation from imDC to maDC efficiently silenced expression of beta 2 integrins CD11b , CD11c , and CD 18 by maDC . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Using a binding assay with 125I labeled fimbriae , we observed that fimbrial binding to the macrophages was inhibited by treatment with CD11a , CD11b , CD11c , or CD 18 antibody but not by that with CD 29 antibody . ^^^ Furthermore , Northern blot analyses showed that the fimbria induced expression of IL 1beta and TNF alpha genes in the cells was inhibited strongly by CD 18 antibody treatment and slightly by CD11a , CD11b , or CD11c antibody treatment . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
CBDC expressed the CD 4 , CD11a , CD 18 , CD45RA , CD 50 and CD 54 antigens but revealed no expression of the CD1a , CD11c , CD 40 , CD45R0 , CD 58 , CD 83 , CD 86 and CD 102 antigens . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We investigated the expression of some adhesion molecules ( E and L selectin , VLA 4 , ICAM 1 , PECAM 1 , VCAM 1 and CD 18 and CD11c chains of beta 2 integrins ) on endothelial and inflammatory cells by immunohistochemistry on cryostat sections of erythema nodosum lesions taken from 15 patients with BD and 12 patients with erythema nodosum of unknown cause . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
CD 10 , CD11b , CD11c , CD 13 , CD 18 , CD 35 , CD 45 , CD66acde , and CD66b were upregulated at 15 min and remained upregulated at 180 min . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We induced beta 2 integrin cross linking by plating PMN onto surface bound mAbs directed against either the common beta chain ( CD 18 ) or the individual alpha chains ( CD11a , CD11b , CD11c ) of LFA 1 , CR 3 , and gp150 / 95 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Neutrophils from healthy subjects were preincubated with various concentrations of these substances and adhesion to plastic bound monoclonal antibodies to CD11a / CD18 , CD11c / CD 18 and CD 44 was determined . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Immunohistochemistry was performed using the APAAP method and directing specific mouse anti human monoclonal antibodies against ICAM 1 ( CD 54 ) , VCAM 1 ( CD 106 ) , E selectin ( CD62E ) , alpha LFA 1 ( CD11a ) , alpha Mac 1 ( CD11b ) , alpha p150 / 95 ( CD11c ) and the beta 2 integrin chain ( CD 18 ) . ^^^ CD 18 , LFA 1 ( CD11a ) , Mac 1 ( CD11b ) and p150 / 95 ( CD11c ) were markedly expressed on infiltrating immunocytes in HTX compared to CABG where no expression of beta 2 integrins was observed . ^^^ CD 18 , LFA 1 ( CD11a ) , Mac 1 ( CD11b ) and p150 / 95 ( CD11c ) were markedly expressed on infiltrating immunocytes in HTX compared to CABG where no expression of beta 2 integrins was observed . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
CBDC expressed CD 4 , CD11a , CD 18 , CD45RA , CD 50 , CD 54 , and CD 123 , but showed no expression of CD1a , CD11c , CD 33 , CD 40 , CD45R0 , CD 80 , CD 83 , and CD 86 and only limited expression of CD 58 , CD 102 , and CD 116 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
These results suggest that fibrin as well as fibrinogen function as a stimulator to macrophages , and leukocyte integrin p 150 , 95 ( CD11c / CD 18 ) , not Mac 1 ( CD11b / CD18 ) , is involved in mediating fibrin stimulatory activity in macrophages . . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Thus , HCL is characterized by high CD 54 , CD 44 , VLA 4 , CD11c , and CD 18 and by low or absent CD11a and L selectin , whereas FL confined to the lymph nodes is characterized by high CD11a , CD 18 , and CD 54 expression . ^^^ Cases with splenomegaly as their prominent feature bear high CD11a , CD 18 , CD 29 , and CD11c on the surface of the leukemic cells . ^^^ The main AM studied either by immunohistochemistry on lymph node sections or by flow cytometry in blood and bone marrow specimens are L selectin , CD11a / CD18 ( LFA 1 ) , CD 54 ( ICAM 1 ) , CD 44 ( HCAM ) , CD11c / CD18 ( gp150 / 95 ) , and CD49d / CD29 ( VLA 4 ) . ^^^ In general , low LFA 1 and CD 54 , high L selectin and CD 44 , and variable CD11c characterize B CLL . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The purified proteins reacted specifically with monoclonal antibodies specific for CD11a , CD11b , CD11c ( the alpha chains of beta ( 2 ) integrins ) , and CD 18 ( the beta chain of beta ( 2 ) integrins ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We analyzed the role of ICAM 1 , CD 18 , CD11a , CD11b , and CD11c during episodes of rejection or infection in patients after lung transplantation and compared the results to episodes without apparent complication . ^^^ ICAM 1 , CD 18 , CD11a , CD11b , and CD11c expressions were detected immunocytochemically on alveolar macrophages . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Flow cytometric analysis of dispersed lung cells showed that expression of IL 10 in the airway reduced the absolute number of Class 2 major histocompatibility complex ( MHC ) ( + ) / CD11c ( + ) ( dendritic cells ) and Class 2 MHC ( + ) / Mac 1 ( bright ) ( macrophages ) cells expressing the costimulatory molecules B7 . 1 and B7 . 2 by 30 % . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Several integrin molecules potentially involved in this process , i . e . , CD 29 , CD 18 , CD11a , CD11b and CD11c , were therefore studied by fluorescence activated cell sorting analysis . ^^^ Among the beta 2 integrins , the expression of LFA 1 ( CD11a ) and of Mac 1 ( CD11b ) , but not of p 150 , 95 ( CD11c ) , was induced by RA . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Mac 1 , but not a mutated Mac 1 in which M 25 was replaced with the homologous sequence of CD11c , co precipitated with uPAR . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
These markers included CD 2 , CD11b , CD11c , CD 18 , CD 16 , CD 54 , CD 56 , CD 98 , CD 25 , CD 122 , HLA class 1 , HLA class 2 , CD 94 , ILT 2 , p58 . 1 , p 70 , and NKp 46 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Human blood monocytes interact with type 1 collagen through alpha 10 beta 2 integrin ( CD11c CD 18 , gp 150 95 ) . ^^^ Adhesion and activation of monocytes on acid soluble type 1 collagen depended on the presence of divalent cations . mAbs directed against integrin subunits CD11c and CD 18 specifically inhibited adhesion and activation of monocytes on type 1 collagen . ^^^ In the case of both acid soluble and pepsin digested collagens , two bands were revealed with mAbs against CD11c and CD 18 integrin subunits . ^^^ Our results demonstrate that monocytes interact with type 1 collagen through CD11c CD 18 ( alpha 10 beta 2 ) integrins , which promote their adhesion and activation . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We demonstrate that ligation of CD11b ( Mac 1 , CR 3 ) or CD11c ( p 150 , CR 4 ) alpha chains of beta 2 integrins by mAbs or soluble chimeric CD 23 ( sCD 23 ) on human freshly isolated monocytes rapidly stimulates high levels of interleukin 1beta production . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The lipopolysaccharide ( LPS ) mediated stimulatory effects of tumor necrosis factor alpha ( TNF alpha ) cytokine production and cell adhesion molecule ( CD11c , CD 18 , CD 14 , CD 54 ) expression in human monocytic THP 1 cells were modulated by treatments of the TW extracts or tacrolimus ( FK 506 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Additionally , the appearance of several activation ( CD 25 , CD 69 , HLA DR ) and adhesion ( CD11a , CD11b , CD11c , CD 18 , CD49b , CD49d , CD 54 ) receptors on CD 4 cells were analyzed . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
On the other hand , the beta 2 integrins CD11a , CD11b , CD11c and CD 18 were all expressed on MAC and DC . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
In conclusion , CD11b , CD 18 , and ICAM 2 seem to be important for PMN transepithelial migration in UC , whereas CD11a , CD11c , ICAM 1 , and ICAM 3 seem central in leukocyte locomotion and aggregation in CD . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We show that the CD14+CD16++ cells express dendritic cell markers : CD 40 , CD 80 , CD 86 , HLA DR , CD11b , CD11c , CD 18 , CD1a , and CD 83 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
As shown by flow cytometry , Mac 1 ( high ) Ia ( + ) cells , which mainly included F4 / 80 ( + ) cells ( macrophages ) and a minor population of CD11c ( + ) cells ( dendritic cells ) , increased in proportion in IHLs but not in SPCs at 6 to 24 hours . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
In these subjects we determined , at baseline and after in vitro activation with 4 phorbol 12 myristate 13 acetate and N : formyl methionyl leucyl phenylalanine , the polymorphonuclear leukocyte membrane fluidity , obtained by labeling the cells with 1 [ 4 ( trimethylamino ) phenyl ] 6 phenyl 1 , 3 , 5 hexatriene , cytosolic Ca ( 2+ ) concentration , obtained by marking the cells with Fura 2 AM , and integrin pattern ( CD11a , CD11b , CD11c , and CD 18 ) , by using the indirect immunofluorescence with a flow cytometer . ^^^ In normal subjects , after activation , we observed a significant increase of the expression of all adhesion molecules , whereas in hypertensives we found an increase of the expression of CD11b , CD11c , and CD 18 but also a decrease of CD11a . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We periodically drew blood from the dorsalis pedis vein and a brachial vein of 11 healthy test persons and 8 patients with stage 3 CVI during experimental venous hypertension in order to evaluate the expression pattern of leukocyte adhesion molecules involved in inflammation : LFA 1 ( CD11a ) , Mac 1 ( CD11b ) , p 150 , 95 ( CD11c ) , CD 18 , VLA 4 ( CD49d ) , and L selectin ( CD62L ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Acquisition of the osteoclast phenotype [ the alphavbeta 3 subunit of the vitronectin receptor ( VNR ) , calcitonin receptor ( CTR ) and F actin ring positive cells ] is associated with loss of monocyte / macrophage associated integrins , specifically CD11b , CD11c and CD 18 . ^^^ Unlike osteoclasts generated in vivo , F actin ring positive ( resorbing ) osteoclasts formed in soluble RANKL in vitro , in the absence of stromal cells , and co expressed CD11c and CD 18 . ^^^ However , when osteoclasts were generated from peripheral blood mononuclear cells ( PBMNCs ) in co cultures with the murine bone marrow stromal cell line 218 ( which does not produce membrane bound RANKL ) in the presence of soluble RANKL , CD11c and CD 18 were not expressed by osteoclasts . ^^^ These findings indicate that the persistent expression of CD11c and CD 18 is not accounted for by RANKL being presented in a soluble form and that membrane bound RANKL is not required for the normal integrin expression in resorbing osteoclasts . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We analyzed the phenotype of CB monocytes in the presence or absence of an inflammatory signal ( rIFN gamma ) and compared them to adult blood ( AB ) ; the expression of HLA DR and 17 different markers ( CD11a , CD11b , CD11c , CD 18 , CD 29 , CD 40 , CD 44 , CD49a , CD49d , CD49e , CD49f , CD 54 , CD 58 , CD62L , CD 80 , CD 86 and CD 102 ) was measured by flow cytometry . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
At 14 weeks of culture , more mature CHMCs expressed CD11b , CD11c , CD 29 , CD49b , CD49c , CD49d , CD49e , CD 51 , CD 61 , and CD 54 and weakly expressed CD 18 and CD11a . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The effect of infection of sheep with the gastrointestinal nematode parasite Trichostrongylus colubriformis on expression of adhesion molecules CD11a , CD11b , CD11c , CD 18 , CD 44 , CD49d and CD62L by peripheral blood eosinophils was examined by flow cytometry . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We examined in 19 subjects with acute ischaemic stroke ( AIS ) the PMN integrin pattern ( CD11a , CD11b , CD11c , CD 18 ) , using indirect immunofluorescence and adopting a flow cytometer , at baseline and during activation , prolonged for 5 and 15 min , with 4 phorbol 12 myristate 13 acetate ( PMA ) . ^^^ At baseline , an increase in the expression of CD11c and CD 18 and a decrease in the CD11b were evident in AIS subjects compared to normals . ^^^ After activation , we found in normals a constant and significant increase of all PMN adhesive molecules , while in AIS subjects , we found an increase in CD11b and CD 18 , a decrease in CD11a and no variation in CD11c . ^^^ While the basal upregulation of CD11c and CD 18 may depend on the PMN spontaneous activation or on the increase of cytokines , the decrease of CD11b may be due to its self consumption . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Physiological concentrations of ICAM 1 ( 0 . 05 500 pM ) were separated from neutrophils by nitrocellulose filters , and cell migration was evaluated using the leading front technique . beta 2 integrins on neutrophils were blocked with antibodies to CD11a , CD11b , CD11c and CD 18 , and migration towards ICAM 1 was examined . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
By flow cytometry , we also measured the expression of leukocyte CD11a , CD11b , CD11c , CD 18 , CD 31 , CD49d , and CD62L ( L selectin ) in 13 patients . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Flow cytometric analysis of membrane antigen density of neutrophils activated with bG CSF revealed an upregulation in the expression of CD11a ( > 114 % ) , CD11b ( > 148 % ) , CD11c ( > 87 % ) , and CD 18 ( > 109 % ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Incubation of PMNs with anti CD 16 prevented the up regulation of beta ( 2 ) integrins , particularly CD11b , which is the alpha chain of complement receptor type 3 , but also CD 18 , which is its beta chain , as well as CD11a and CD11c . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
They expressed CD 4 , CD11a , CD11b , CD11c , CD 18 , CD 32 , CD 33 , CD45R0 , CD 48 , CD 50 , CD 54 , CD 58 , CD 64 , CD 86 , CD 102 , CD 116 , CD 123 , and HLA DR ; showed no expression of CD1a and CD 83 ; and weak expression of CD 16 , CD45RA , and CD 80 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
CD 18 ( A270V ) supports , at a diminished level , CD11b / CD18 ( Mac 1 , alphaMbeta 2 integrin ) and CD11c / CD18 ( p 150 , 95 , alphaXbeta 2 integrin ) expression and function but not CD11a / CD18 ( LFA 1 , alphaLbeta 2 integrin ) expression . ^^^ CD 18 ( C590R ) and CD 18 ( R593C ) show a decreasing capacity to associate with the CD11a , CD11c and CD11b subunits . ^^^ CD 18 ( A270V ) supports , at a diminished level , CD11b / CD18 ( Mac 1 , alphaMbeta 2 integrin ) and CD11c / CD18 ( p 150 , 95 , alphaXbeta 2 integrin ) expression and function but not CD11a / CD18 ( LFA 1 , alphaLbeta 2 integrin ) expression . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Overexpression of protein kinase C zeta ( PKC zeta ) in the leukemic myeloid cell line U 937 ( U 937 PKC zeta cells ) , previously shown to induce leukemic cell differentiation , resulted in nearly complete downregulation of leukocyte integrins CD11a , CD11b , CD11d , and CD 18 , but not CD11c from the cell surface . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
In this study we analysed blood samples taken from the dorsalis pedis vein and a brachial vein of 11 healthy test persons and 8 patients with venous leg ulcer under experimental venous hypertension in order to examine changes in the expression of leukocyte adhesion molecules ( LFA 1 ( CD11a ) , Mac 1 ( CD11b ) , p 150 , 95 ( CD11c ) , CD 18 , VLA 4 ( CD49d ) and L selectin ( CD62L ) ) which are involved in the adhesion steps of leukocytes to endothelial cells for transmigration into tissues . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Our results demonstrated that CD 7 ( + ) AML expressed Ang 2 mRNA frequently and integrin family adhesion molecules ( CD11c and CD 18 ) intensively , suggesting the close correlation with endothelial cells . ^^^ On the other hand , in t ( 8 ; 21 ) AML cells , expression of Ang 2 was infrequent and expression of integrin family adhesion molecules ( CD11b , CD11c and CD 18 ) was weak , suggesting the sparse association with endothelial cells . ^^^ As for CD 7 ( + ) AML cells , despite the frequent and intense expression of endothelial cell associated molecules ( such as Ang 2 , CD11c and CD 18 ) , intensity of Tie 2 expression was quite low ( P < 0 . 05 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The Fes expressing differentiated cells became adherent , had distinctive macrophage morphology , and exhibited increased expression of myelomonocytic differentiation markers , including CD11b , CD11c , CD 18 , CD 14 , and the macrophage colony stimulating factor receptor . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Splenocyte populations with CD 19 ( + ) , Mac 1 ( + ) , Gr 1 ( + ) and CD11c ( + ) positive surface markers significantly increased in immune mice compared to controls ones . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
CD11c is a member of the beta ( 2 ) integrin family of adhesion molecules that , together with CD 18 , forms a heterodimeric receptor on the surface of myeloid , NK , dendritic , and certain leukemic , lymphoma , and activated lymphoid cells . ^^^ Monocytic differentiation is associated with an induction of both CD11c and CD 18 gene expression . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The adhesion molecule expression pattern was consistent in all patients : L Selectin and CD11c were negative , CD11alpha and CD 18 weakly positive and CD 54 strongly positive . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Integrins CD11c and / or CD 18 , Toll like receptors ( TLRs ) , as well as CD 55 , have been suggested to serve this function . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Lkt binds to beta ( 2 ) integrins on the surface of bovine leukocytes . beta ( 2 ) integrins have a common beta subunit , CD 18 , that associates with three distinct alpha chains , CD11a , CD11b , and CD11c , to give rise to three different beta ( 2 ) integrins , CD11a / CD18 ( LFA 1 ) , CD11b / CD18 ( Mac 1 ) , and CD11c / CD18 ( CR 4 ) , respectively . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The PMN adhesion molecules ( CD11a , CD11b , CD11c , CD 18 ) were evaluated using indirect immunofluorescence and a flow cytometer , at baseline and after in vitro activation with 4 phorbol 12 myristate 13 acetate ( PMA ) and N formyl methionyl leucyl phenyl alanine ( fMLP ) . ^^^ At baseline , in diabetic subjects the phenotypical expression of CD11a and CD11b was significantly reduced and CD11c was increased , whereas CD 18 was unchanged in comparison with normals . ^^^ Considering type 1 and 2 diabetic subjects separately , CD11a was reduced and CD11c was increased in both subgroups , CD11b was decreased only in type 1 diabetics and CD 18 , decreased in type 1 , was increased in type 2 subjects . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Cells phenotypes were identified using three color flow cytometry analysis for the following receptors HLA DR , CD 80 , CD 83 , CD 86 , CD11c , CD 18 , CD 54 , CD 58 , CD 3 , CD 4 , CD 8 , CD 19 , CD 20 , CD 14 , CD 16 , CD 56 . ^^^ HLA DR molecules , co stimulatory receptors CD 80 , CD 86 , CD 83 and adhesion molecules CD 18 , CD11c , CD 54 , CD 58 , were analyzed by two color immunofluorescence microscopy on ST serial sections . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Cell surface expression of CD 18 , CD11a , CD11b , CD11c , CD 50 , and CD 54 was not affected by Na ( 2 ) SO ( 3 ) treatment . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The cells were exposed to 1 nm FMLP , 5 pm free ICAM 1 , or antibodies binding ICAM 1 or the beta 2 integrins CD11a , CD11b , CD11c and CD 18 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
As evidenced by flow cytometry , ATRA ( at 1 microM ) clearly and donor independently suppressed the expression of all integrin chains investigated ( CD11a , CD11b , CD11c , and CD 18 ) , most strikingly of CD11a . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
We evaluated the expression of some PMN integrins ( CD11a , CD11b , CD11c , CD 18 ) , using flow cytofluorimetry , at baseline and after in vitro activation with 4 phorbol 12 myristate 13 acetate . ^^^ Type 2 diabetic subjects with MVC showed , compared to normals , an increase of CD11a and CD 18 and a decrease of CD11b and CD11c . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Following an additional 3 days of culture in the presence of GM CSF , IL 4 , IL 1beta , IL 6 , TNFalpha , and PGE ( 2 ) , cells ( 82 . 0 + / 5 . 8 % CD83+ ) displayed a mature DC morphology and phenotype , including expression of CD11b , CD11c , CD 18 , CD 25 , CD 40 , CD 54 , CD 58 , CD 80 , CD 86 , HLA class 1 , and HLA DR as well as expression of CCR 7 but not CCR 5 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Compared with PMN , monocytes exhibited an expression level that was similar for CD 18 , higher for CD11a and CD11c , but lower for CD11b . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
CD 18 , CD 44 , CD 23 , CD 5 , CD11c and CD 43 were positive in different B cell subpopulations . 78 % of B cells were IgD positive and ratio kappa / lambda was 1 . 26 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Fetal granulocytes tend to have a lower expression of CD11b , CD11c , CD 18 , and CD 32 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
GBS induced TNF alpha release was inhibited by monoclonal antibodies directed against each of the components of CR 3 and CR 4 : the common integrin beta subunit CD 18 and the alpha subunits CD11b ( of CR 3 ) and CD11c ( of CR 4 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The majority of EPCs expressed monocyte / macrophage markers such as CD 14 ( 95 . 7+ / 0 . 3 % ) , Mac 1 ( 57 . 6+ / 13 . 5 % ) , and CD11c ( 90 . 8+ / 4 . 9 % ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Eotaxin was mainly expressed in subepidermal tissue in close proximity to eosinophils that expressed high levels of adhesion molecules ( CD11b , CD11c , CD 18 and CD49d ) and the activation marker HLA DR . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
In 27 subjects with VAD we examined , at baseline and after in vitro activation with 4 phorbol 12 myristate 13 acetate ( PMA ) , the PMN integrin pattern ( CD11a , CD11b , CD11c , CD 18 ) using indirect immunofluorescence and a flow cytometer . ^^^ At baseline VAD subjects showed an increase of CD11a and CD 18 and a decrease of Cd11b and Cd11c as compared to normal subjects . ^^^ After activation , in normal subjects , we found an increase in the expression of all integrins , while in VAD subjects we observed an increase of CD11b and Cd11c and a decrease of Cd11a and CD 18 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Most of the DCs express immunocytochemically detectable antigens like : S 100 , CD1a , CD 40 receptor , adhesion molecules ( ICAM 1 or CD 54 , LFA 1 and LFA 3 ) , integrins ( CD11a , CD11c and CD 18 ) , CD 45 , CD 54 , co stimulatory molecules ( B 7 1 or CD 80 , B 7 2 or CD 86 ) , F 418 , MHC class 1 and 2 and DEC 205 , multilectin receptor , immunostimulatory cytokine ( IL 12 ) and , of course , Fc and complement receptors . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
DESIGN : This study utilized quantitative flow cytometry to determine whether the expression of surface adhesion molecules : CD 18 , CD11a , CD11b , and CD11c on cord blood neutrophils using mean channel fluorescence values ( MCF ) . ^^^ RESULTS : MCF values were significantly higher in infants born to pre eclamptic women vs controls : CD 18 ( 432 . 0+ / 236 . 3 vs 230 . 5+ / 97 . 9 ; p=0 . 002 ) , CD11a ( 552 . 9+ / 272 . 4 vs 326 . 9+ / 268 . 6 ; p=0 . 003 ) , CD11b ( 937 . 2+ / 521 . 9 vs 576 . 6+ / 352 . 9 ; p=0 . 025 ) , and CD11c ( 228 . 5+ / 130 . 3 vs 133 . 0+ / 77 . 1 ; p=0 . 006 ) , respectively . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies directed against CD 18 , CD11a , CD11b , CD11c , CD 21 , CD 3 , CD 4 , CD 8 and Major Histocompatibility Complex class 1 and 2 ( MHC 1 and MHC 2 ) were also employed . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The defect in T cell proliferation with SEA was more severe in splenocytes from mice deficient in CD 18 , CD11b , or CD11d than in CD11a deficient splenocytes , with a normal response in CD11c deficient splenocytes . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
RESULTS : Good mobilizing patients , defined as those who collected their target in one apheresis procedure , had significantly fewer cells that expressed CD11a ( LFA 1 ) and CD 54 ( ICAM 1 ) and borderline fewer that expressed CD11c , CD49d ( VLA 4 ) , and CD49d ( VLA 5 ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
In a group of patients with mild CRF we determined , at baseline and after in vitro activation with 4 phorbol 12 myristate 13 acetate ( PMA ) and N formyl methionyl leucyl phenylalanine ( fMLP ) , the polymorphonuclear leukocytes ( PMN ) beta 2 integrin pattern ( CD11a , CD11b , CD11c and CD 18 ) by using indirect immunofluorescence with a flow cytometer . ^^^ At baseline we observed an increase in the phenotypical expression of CD11b , CD11c and CD 18 in CRF patients . ^^^ In normal subjects , after activation with both agents , we noted an increase of all adhesion molecules , while in CRF patients we found an increase in the expression of CD11b , CD11c and CD 18 but not of CD11a . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The beta 2 integrins are found exclusively in leukocytes and they are composed of a common beta chain , CD 18 , and one of four unique alpha chains , CD11a ( alphaL subunit ) , CD11b ( alphaM subunit ) , CD11c ( alphaX subunit ) , or CD11d ( alphaD subunit ) . alphaX beta 2 which binds several ligands including fibrinogen and iC3b is expressed in monocytes / macrophages and dendritic cells playing an important role in the host defense . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Neutrophils were treated with IL 15 and cell surface expression of CD11a , CD11b , CD11c and CD 18 was monitored by flow cytometry . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
In a group of 18 subjects with acute deep venous thrombosis ( DVT ) , evidenced by clinical examination and echo color Doppler , we examined the phenotypical expression of the polymorphonuclear leukocyte ( PMN ) beta 2 integrins ( CD11a , CD11b , CD11c , CD 18 ) , obtained by using a flow cytofluorimeter . ^^^ In DVT subjects , at baseline , the phenotypical expression of CD11b was decreased and that of CD11c was increased when compared with normal controls ; no difference was found in CD11a and CD 18 expression . ^^^ In normal subjects PMN activation with both activators led to a constant increase of all PMN adhesion molecules ; in DVT subjects CD11b , CD11c and CD 18 increased , while CD11a expression did not show any change . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Hearts were procured at 1 , 2 , 4 , and 8 weeks after ESC transplantation and analyzed by immunohistochemistry to assess immune cell infiltration ( CD 3 , CD 4 , CD 8 , B 220 , CD11c , Mac 1 , and Gr 1 ) and ESC differentiation ( hematoxylin and eosin ) . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
Comparison of infected PMNLs with uninfected cells showed a decrease of up to 50 % in the expression of CD11b , CD11c , and CD 18 . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
The lack of CD 18 results in the deficiency of all beta 2 integrins , i . e . , CD11a / CD18 ( LFA 1 ) , CD11b / CD18 ( Mac 1 / CR3 ) , CD11c / CD18 ( p 150 , 95 / CR4 ) , and CD11d / CD18 . ^^^ Similarly to CD 18 hypomorph mice , CD11c / mice expressed higher levels of MCP 1 , compared to both WT and CD11a / mice , as determined by in vitro analysis of MCP 1 secretion by bone marrow derived dendritic cells and in vivo analysis of MCP 1 mRNA expression in B . burgdorferi infected hearts . ^^^ Overall , our results suggest that the increased severity of Lyme carditis in CD 18 hypomorph mice is caused by deficiency in CD11a or CD11c , possibly via different mechanisms . . ^^^
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20702 and P05107	Pubmed	SVM Score :0.0
NA