Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.62077872
A reliable flow cytometric assay for human CD 18 in transplant recipients was developed based on : ( a ) the availability of human specific CD 18 monoclonal antibodies and ( b ) the observation that human CD 18 can form chimeric heterodimers with murine CD11a on the cell surface . 0.62077872^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.66644129
These studies suggest that human CD 18 will form a heterodimer with murine CD11a and that human CD 18 is not expressed on the cell surface of cells not expressing CD 11 . 0.66644129^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.96361113
This is in contrast to neutrophil adhesion to ICAM 1 transfected cells , where LFA 1 binds with a higher avidity than Mac 1 to ICAM 1 . 3 ) Following stimulation , the capacity of LFA 1 to support aggregate formation decreases with time at a rate approximately 3 fold faster than that of Mac 1 . 0.96361113^^^ We report that 1 ) LFA 1 binds ICAM 3 as its primary ligand supporting homotypic adhesion , although the possibility of other ligands was also detected . 2 ) Mac 1 binding to an unidentified ligand supports homotypic adhesion with an efficiency comparable to LFA 1 at low shear rates of approximately 100 s 1 . 0.84119481^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Paxillin binding to the alpha 4 integrin subunit stimulates LFA 1 ( integrin alpha L beta 2 ) dependent T cell migration by augmenting the activation of focal adhesion kinase / proline rich tyrosine kinase 2 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To investigate this problem in the leukocyte integrin alpha L beta 2 ( LFA 1 ) , we generated a series of cytoplasmic truncation or internal substitution mutants of the alpha L and beta 2 cytoplasmic domains , and assessed their biochemical and functional properties upon ectopic expression in constitutively adherent cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The leukocyte integrin alpha L beta 2 ( LFA 1 ) is important in transendothelial migration . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Although it is well accepted that intercellular adhesion involving the CD11a / CD18 ( LFA 1 ) complex is critical in a wide array of T cell dependent processes , recent demonstrations of an LFA 1 high avidity state , induced by triggering the T cell receptor ( TCR ) complex , has raised questions about the intracellular signals generated and molecular events leading to effective cell coupling , as well as their orderly sequence . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We asked if age dependent DNA hypomethylation might contribute to overexpression of the T cell ITGAL gene , which encodes CD11a , a subunit of LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Bisulfite sequencing was used to compare methylation patterns in the promoter and 5 ' flanking regions of the ITGAL gene , encoding CD11a , in normal human T cells , which express LFA 1 , and fibroblasts , which do not . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
It was found that the MoAbs against LFA 1 ( CD11a ) , CD11c , LFA 3 ( CD 58 ) , ICAM 1 ( CD 54 ) or HLA DR could significantly suppress T cell proliferation in an allogeneic mixed lymphocyte reaction ( P < 0 . 05 ) , while being unable to inhibit clustering of BDC with T cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Although CD21+ ( CR 2 ) and CD35+ ( CR 1 ) cells all expressed DAF , CD11a ( LFA 1 ) levels correlated inversely with those of DAF . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies ( MoAbs ) against CD11a , CD11b , CD 18 , and CD 54 and a polyclonal anti human fibronectin antibody do not inhibit attachment of either B or T lymphoblastic cells to MSC . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
TS treated HL 60 cells exhibited binucleated morphological appearance ; however , the cells did not exhibit chemotaxis , phagocytosis , or changes in the expression of the cell surface markers , CD11a and CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
HBL 4 cells lacked CD 23 ( H 107 ) , CD11a ( LFA 1 ) , and latent membrane protein ( LMP ) but expressed CD 54 ( ICAM 1 ) at low levels , whereas HBL 5 cells showed the high level of expression of CD 54 and faint expression of LMP but lacked CD11a . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
JK T 1 had lymphocyte function associated antigen 1 ( LFA 1 ) ( CD11a , CD 18 ) on its surface and could adhere to the hematologic stromal layer . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
MAY . 035 was shown as to recognize the alpha chain of LFA 1 ( CD11a ) , and both MAY . 017 and MAY . 044 the beta chain of the beta 2 integrin family ( CD 18 ) . ^^^ Three murine monoclonal antibodies ( MAbs ) directed against human lymphocyte function associated antigen 1 ( LFA 1 , CD11a / CD18 ) , designated as MAY . 017 , MAY . 035 , and MAY . 044 , were newly generated . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Inhibition of intravascular leukocyte leukocyte aggregation with mAb against CD11b ( Mac 1 ) showed partial inhibition of hemorrhage , while mAb against CD11a ( LFA 1 ) showed no inhibitory activity . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The addition of mAb directed at the CD11a or CD 18 molecules almost completely inhibited the responses to ICAM 2 Rg . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We found that MCP 1 induced expression of CD11c ( p 150 , 95 alpha subunit ) and CD11b ( Mac 1 alpha subunit ) , and caused little or no change of CD11a ( lymphocyte function associated Ag 1 alpha subunit ) , very late activation Ag 4 , or leukocyte adhesion molecule 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The leukocyte integrins consist of a common CD 18 ( beta ) subunit and individual , noncovalently associated alpha subunits designated CD11a , CD11b , and CD11c . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Mouse L cells cotransfected with both MHC class 2 ( DR2A or DR 7 ) and ICAM 1 stimulated T cells at 100 fold lower concentrations of SEA as compared to the single transfected cells . mAb reacting with the CD11a , CD 18 , or ICAM 1 molecules efficiently inhibited T cell activation with the cotransfected HLA DR2A / ICAM 1 cell but did not influence T cell activation with the HLA DR2A single transfected cell . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of the CD 54 ( ICAM 1 ) and CD11a ( LFA 1 ) adhesion molecules in oral mucosal inflammation . ^^^ The present study evaluated the expression of CD 54 and its ligand , CD11a ( lymphocyte function associated antigen , LFA 1 ) in oral lesions of lichen planus , recurrent aphthous stomatitis , secondary Sjgren ' s syndrome and traumatic ulceration using an immunoperoxide technique . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Positivity of CD 18 Ad cells with the common beta 2 integrin ( CD 18 ) is largely attributable to expression of alpha L ( CD11a ) chain , rather than alpha M ( CD11b ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Fresh frozen sections from 12 monoclonal CNS NHLs ( 11 primary , one secondary ) were stained with monoclonal antibodies to LFA 1 alpha chain ( CD11a ) , beta chain ( CD 18 ) and , ICAM 1 ( CD 54 ) . ^^^ Non tumor brain from two patients and non tumor cerebral blood vessels showed no staining with CD11a , CD 18 or CD 54 antibodies . ^^^ Normal SCID mouse brains showed no staining with CD11a , CD 18 , CD 54 or mouse ICAM 1 antibodies . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Experiments have also demonstrated the ability of monoclonal antibodies with specificity for two human T cell adhesion molecules , lymphocyte function associated ( LFA ) antigen 1 ( LFA 1 , CD11a , alpha chain / CD18 , beta chain ) and LFA 2 ( CD 2 ) , to inhibit conjugate formation in vitro . ^^^ Studies in a nonhuman primate model were undertaken to determine whether the in vivo administration of monoclonal antibodies with specificity for the alpha chain of LFA 1 ( CD11a ) or with specificity for CD 2 could modulate in vivo T cell function . ^^^ Modulation of the LFA 1 molecule on circulating T cells occurred as a result of treatment with anti CD11a ( or the combination of anti CD11a plus anti CD 2 ) , whereas treatment with anti CD 2 ( or anti CD11a plus anti CD 2 ) did not result in modulation of the CD 2 antigen despite detectable levels of circulating anti CD 2 mAb . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The adherence of both L 1210 and L5178Y to MSC was unaffected by rat monoclonal antibodies to murine CD11a , CD11b , and CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This A / R induced hyperadherence was significantly diminished by monoclonal antibodies ( MAb ) directed at CD11a , CD11b , CD 18 or ICAM 1 , but not by MAb directed at ELAM 1 . ^^^ The inhibitory effects of anti CD11a and anti CD11b were additive and equivalent to that of anti CD 18 MAb . ^^^ However , immunofluorescence flow cytometry indicated that incubation of neutrophils in supernatants of A / R conditioned HUVEC elicited an increase of surface CD11b and CD 18 , but not CD11a . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The leukocyte integrin LFA 1 ( CD11a / CD18 ) plays a key role in many adhesive interactions involving cells of the immune system . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Ling Zhi 8 ( LZ 8 ) , a novel immunomodulatory protein , markedly enhanced the expression of CD11b , but not CD11a , CD 13 , CD 14 , CD 18 , CD 33 or HLA DR , on the U 937 cell line in a dose dependent fashion . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Northern blot analysis indicated the presence of CD11a , CD11c , and CD 18 mRNA in the AMs . ^^^ We conclude that : ( 1 ) AMs obtained from human and nonhuman primates constitutively express predominantly CD11a / CD18 surface antigen and mRNA , ( 2 ) chemotaxis of AMs is CD 18 dependent , and ( 3 ) adhesion of AMs to an alveolar epithelial cell monolayer is partly but not completely dependent on the beta 2 integrins . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Antibodies to CD11a , CD11b , and CD 18 on PMN also inhibited PMN epithelial adherence . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of three alpha chains designed as CD11a , CD11b , CD11c , a common beta chain CD 18 , and of a ligand for several integrins CD 54 ( ICAM 1 ) was studied on alveolar macrophages of patients with active and inactive sarcoidosis and in control subjects . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The mean fluorescence intensity ( MFI ) of monocyte CD11a was enhanced by interleukin 2 ( IL 2 ) , TNF alpha and TNF beta , and that of CD11b , CD11c and CD 18 was increased by IL 2 , IL 4 , TNF alpha and TNF beta . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
On the other hand , the expression of LFA 1 ( CD11a and CD 18 ) was more or less similar among the cell lines with and without HTLV 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Fluorescence and neutrophil / myocyte adherence followed the same time course , and both were blocked by monoclonal antibodies to CD 18 , CD11b , and ICAM 1 , but mAb R7 . 1 , recognizing a functional epitope on CD11a , was not inhibitory . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The beta 2 ( B 2 ) integrin ( leukocyte integrin , CD11 / CD18 ) subfamily comprising three members , each consisting of a shared beta subunit ( CD 18 ) non covalently associated with unique alpha subunits ( CD11a , CD11b , CD11c ) . ^^^ In biopsies obtained from positive tuberculin tests and from the clinically involved skin of patients with LP , PV , MF or PPC , a multifocally occurring , suprabasal peroxidase positive reaction was observed on the membranes of the HKs when the monoclonal antibodies ( MABs ) Dako CD11a , Dako p 150 , 95 or Dako CD 18 were used . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The activities of anti CD 3 stimulated human CD4+ PBL were compared to anti CD 3 plus anti CD 2 , anti CD 4 , or anti CD11a ( LFA 1 ) stimulated cells . [ 3H ] thymidine incorporation , lymphokine receptor expression , expansion of cell numbers , and lymphokine mRNA and protein were measured . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Treatment of the PMN with mAb against CD11a , CD11b , or CD 18 markedly reduced PMN adhesion to PiV 2 infected 1 degree TEC and 9HTEo cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
These 6 included a new anti canine CD 18 mAb , 2 anti canine CD11a mAb , 2 anti canine CD11c mAb , and a mAb which recognizes a novel canine CD11 / CD18 related macrophage antigen , designated LeuCAMmac , which is described in a separate report . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In this model system , mAb to either the alpha ( CD11a ) or beta ( CD 18 ) chain of LFA 1 or ICAM 1 ( CD 54 ) reversed the suppression of B cell function by suppressor CD4+ T cells significantly . ^^^ The role of leukocyte function associated Ag 1 ( LFA 1 , CD11a / CD18 ) and intercellular adhesion molecule 1 ( ICAM 1 , CD 54 ) interactions in the suppression of human B cell function by immobilized anti CD 3 activated CD4+ T cells was examined by studying the effects of mAb to these determinants . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition , the activation antigens ( HLA DR ) and two adhesion molecules , including the alpha chain of the leukocyte function associated antigen 1 ( LFA 1 alpha : CD11a ) and its ligand ( intercellular adhesion molecule 1 : ICAM 1 : CD 54 ) expressed on T cells , were compared . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We investigated the role of lymphocyte function associated antigen 1 ( LFA 1 ) in human T cell polarization and migration assay by using monoclonal antibody specific to beta chain ( CD 18 ) and alpha chain ( CD11a ) . ^^^ T cell polarization in response to fetal calf serum ( FCS ) and colchicine was suppressed by the addition of CD 18 and CD11a antibodies . ^^^ Furthermore , T cell migration in response to lymphocyte chemotactic factor ( LCF ) and casein was markedly depressed by the addition of CD 18 and CD11a antibodies . ^^^ Additional studies to evaluate effects of interleukin 8 ( IL 8 ) on polarization and migration of T cells preincubated with CD 18 or CD11a antibody showed that IL 8 restored the capability of migration of T cells , whereas did not restore polarization activity of such cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Adhesion of LFA 1+ T cells to unstimulated EC was inhibited ( average inhibition of 58 % ) with mAb to CD11a or CD 18 . ^^^ Considerably less inhibition of adhesion occurred with mAb to CD11a or CD 18 ( average inhibition , 20 % ) when LFA 1+ T cells were incubated with rTNF alpha stimulated EC . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast , other anti LFA 1 mAbs ( CD11a and CD 18 ) suppressed this anti CD 2 mAb induced T cell proliferation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Blockade of CD11a , CD11b and CD 18 with saturating concentrations of specific mAb did not inhibit the release of cytokines from LPS stimulated monocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
With this , we analyzed the phenotypes of CD34+ HSCs and showed that primitive HSCs or CD34+CD33 cells expressed adhesion molecules such as CD 43 , CD 44 , CD11a , CD11c , CD 18 , and leukocyte adhesion molecule ( LAM 1 ) . ^^^ The more primitive hematopoietic cells or CD34+CD38 cells also expressed CD11a and CD 18 with an incidence of 20 % to 30 % . ^^^ When CD 18 or CD11a antibody was added to a coculture system of CD34+CD33 cells with stromal layers , the number of generated CFCs decreased significantly compared with the no antibody control . ^^^ Leukocyte function associated antigen 1 ( LFA 1 ) ( CD11a / CD18 ) was expressed on some populations of hematopoietic cells and contributed to the proliferation by interacting with stromal cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD11a ( LFA 1 ) and CD11b are less expressed , whereas CD11c is preserved . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Ovine haemopoietic progenitor cells that form colonies ( CFC ) in soft agar cultures were compared to more mature bone marrow cells for their level of expression of the adhesion receptor molecules ovine ( ov ) CD 44 , ov CD11a ( LFA 1 ) and ov CD 58 ( LFA 3 ) as well as the 175 antigen using specific monoclonal antibodies . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Other molecules involved in cell / cell adhesion are LFA 1 ( CD11a / CD18 ) , Mac 1 ( CD11b / CD18 ) and their ligand ICAM 1 ( CD 54 ) , p 150 , 95 ( CD11c / CD18 ) , LFA 3 ( CD 58 ) , CD 44 , and LECAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LFA 1 alpha ( CD11a ) and LFA 1 beta ( CD 18 ) and their ligand ICAM 1 ( CD 54 ) , H CAM ( lymphocyte homing receptor ; CD 44 ) and N CAM ( CD 56 ) . ^^^ All plasma cells from normals and multiple myeloma patients were negative for CD 2 , CD11a and CD 18 . ^^^ LFA 1 alpha ( CD11a ) and LFA 1 beta ( CD 18 ) and their ligand ICAM 1 ( CD 54 ) , H CAM ( lymphocyte homing receptor ; CD 44 ) and N CAM ( CD 56 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of the immunoglobulin related molecules CD 2 , CD 54 ( ICAM 1 ) and CD 58 ( LFA 3 ) was higher on RA SFL when compared to RA PBL or CO PBL , and similar results were obtained with the beta 2 integrin subunits CD11a and CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Most striking , however , was the observation that lymphocytes from A LAK cultures consistently contained a high density of CD 2 , CD11a , and CD 18 adhesion molecules , as indicated cytometrically by their `` bright ' ' fluorescence intensity . ^^^ The CD11a , CD 18 , and partially CD 2 molecules were important in the A LAK cytolytic mechanism against AML , since blocking of these structures with monoclonal antibodies ( MAb ) significantly decreased the antileukemia effect . ^^^ Additionally , the ability of A LAK to adhere to plastic was most strongly inhibited by anti CD11a MAb and less , but significantly , by MAb against CD 2 , CD 18 , and CD 56 molecules . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The adhesion and subsequent migration of freshly isolated NK cells was mainly mediated by CD11b / CD18 , because migration could be inhibited by 80 + / 8 % anti CD11b ( Mac 1 ) antibodies but not with antibodies against CD11a ( LFA 1 ) or CD11c ( p 150 , 95 ) , the other alpha chains of the beta 2 integrins . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
For treatment of steroid resistant severe graft versus host disease , a murine monoclonal antibody ( 25 . 3 ) against the alpha chain ( CD11a ) of the lymphocyte function associated antigen 1 ( LFA 1 ) was infused into a patient with posthepatitic aplastic anemia who had undergone allogeneic bone marrow transplantation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The degree of expression of LFA 1 ( CD11a ) remains to be characterised fully . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Large cell lymphomas often involve the stomach ; commonly express the lymphocyte adhesion molecules CD 44 , LFA 1 ( CD11a and CD 18 ) , and CD 54 ; and may express monotypic cytoplasmic immunoglobulin in approximately one third of cases . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Lymphocyte function associated antigen 1 ( LFA 1 ) ( CD11a / CD18 ) expression on bone marrow derived plasma cells from normal individuals , patients with monoclonal gammopathies of undetermined significance ( MGUS ) , and patients with multiple myeloma ( MM ) was studied by immunofluorescence microscopy and flow cytometry using a new monoclonal antibody ( MoAb ) F8 . 8 . ^^^ This MoAb recognizes the alpha chain ( CD11a ) of LFA 1 as determined by immunoprecipitation , and inhibits T cell induced cytotoxicity . ^^^ Using the anti CD11a MoAb F8 . 8 , a strong correlation was found between LFA 1 expression and disease activity in MM , as defined by clinical performance and serum M protein level . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The data demonstrate that whatever the source of lymphocytes used for ALG preparation ( thymocytes , thoracic duct lymphocytes , B or T cell lines ) , ( 1 ) ALG react with both B and T cell lines , and ( 2 ) ALG contain antibodies specific for B cells ( eg , CD 21 ) or common to T and B cells ( eg anti beta 2 microglobulin , anti HLA DR , CD 18 , CD11a ) in addition to T cell specific antibodies . ^^^ This selective B cell antiproliferative property of ALG was not reproduced with CD11a , CD 18 , CD 21 , CD 24 , or anti HLA DR monoclonal antibodies ( MoAbs ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The HC were shown to express the integrin beta 1 subfamily molecules , LFA 1 ( CD11a ) and p 150 , 95 ( CD11c ) in high density but lacked CR 3 ( CD11b ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The in vivo studies have mostly utilized antibodies to CD 18 , the common beta subunit of CD11a , b , c / CD18 molecules and thus have blocked the function of all three family members , making evaluation of the role of individual subunits impossible . ^^^ The contribution of LFA 1 ( CD11a / CD18 ) and MAC 1 ( CD11b / CD18 ) to the in vivo migration of polymorphonuclear leucocytes to inflammatory reactions in the rat . ^^^ Here we report the effects on polymorphonuclear leucocyte ( PMNL ) adhesion and in vivo migration of a new monoclonal antibody ( mAb ) TA 3 , which recognizes and blocks rat CD11a / CD18 ( LFA 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
These include LFA 1 alpha and beta chains ( CD11a , CD 18 ) , and ICAM 1 ( CD 54 ) . ^^^ It seems likely then that neoplastic B cells without CD11a , CD 18 and CD 54 surface molecules are unable to associate with FDC and now invade other compartments . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD11a ( LFA 1 ) was more expressed in NHL and IDL than in B CLL ( P = . 047 ) , although it was demonstrable in 74 . 2 % of cases ; CD11c was more expressed in B CLL ( P less than . 0001 ) , and its expression was preserved in almost all of the cases of small lymphocytic lymphoma . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Also , both lymphocyte function associated antigen 1s , CD11a and CD 18 , and intercellular adhesion molecule 1 were demonstrated on the tumor cells and vascular walls in the lesions . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Furthermore , cells from all clones analyzed expressed CD 5 , CD 7 , CD45RO ( UCHL 1 ) , CD11a ( LFA 1 ) , CD 25 , and HLA DR antigens . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In this model system , mAb to either the alpha ( CD11a ) or beta ( CD 18 ) chain of LFA 1 or ICAM 1 ( CD 54 ) inhibited B cell responses significantly . ^^^ The role of leukocyte function associated Ag 1 ( LFA 1 , CD11a / CD18 ) and intercellular adhesion molecule 1 ( ICAM 1 , CD 54 ) interactions in human T cell and B cell collaboration was examined by studying the effect of mAb to these determinants on B cell proliferation and differentiation stimulated by culturing resting B cells with CD4+ T cells activated with immobilized mAb to the CD 3 molecular complex . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Adhesion molecules CD11a , CD 18 , and ICAM 1 on human epidermal Langerhans cells serve a functional role in the activation of alloreactive T cells . ^^^ Human epidermal cells ( EC ) , Ficoll enriched for LC ( greater than 10 % ) , were incubated with monoclonal antibodies ( MoAb ) specific for the adhesion molecules CD11a ( LFA 1 alpha ) , CD 18 ( LFA 1 beta ) , or ICAM 1 ; staining was evaluated by fluorescence microscopy . ^^^ After 12 h of culture only HLA DR+ cells ( LC ) expressed CD11a , CD 18 , and ICAM 1 . ^^^ MoAb against CD11a , CD 18 , or ICAM 1 reduced the allostimulatory capacity of LC by greater than 70 % ; combinations of these MoAb reduced proliferation even more ( 90 % ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The mean ( SE ) percentages of lymphocytes expressing CD11a ( RA 93 . 4 ( 1 . 7 ) % ; controls 97 . 2 ( 1 . 8 ) % ) and CD 18 ( RA 91 . 3 ( 2 . 3 ) % ; controls 97 . 0 ( 2 . 6 ) % ) were lower and the percentage of monocytes expressing CD11b ( RA 86 . 9 ( 11 . 4 ) % ; controls 78 . 4 ( 11 . 9 ) % ) and CR 1 ( RA 62 . 6 ( 15 . 5 ) % ; controls 36 . 6 ( 17 . 6 ) % ) were higher in patients with RA than in controls . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies R15 . 7 ( anti CD 18 ) , R7 . 1 ( anti CD11a , LFA 1 ) , and R6 . 5 ( anti ICAM 1 ) , administered intravenously before C5a exposure , strongly inhibited leukocyte adherence while antibody LM 2 ( anti CD11b , Mac 1 ) produced significant , but weaker , inhibition . ^^^ These data confirm earlier findings establishing a role for CD 18 in leukocyte adhesion in vivo and extend those observations to implicate both CD11a and CD11b in that adhesion . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The role of leucocyte integrins in phagocyte function has been studied by comparing normal neutrophils with those from a patient with partial leucocyte adhesion deficiency ( LAD ) , in whom the levels of CD11b and CD11c were 10 % of controls , whereas CD11a levels were normal . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Late treatment with anti LFA 1 ( CD11a ) antibody prevents cerebral malaria in a mouse model . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies ( MoAbs ) to CD11a , CD11b , and CD 18 on the neutrophils inhibited this migration by 52 % + / 11 % , 29 % + / 19 % , and 90 % + / 7 % , respectively . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The phosphorylated CD 18 subunit was associated with both CD11a and CD11b . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We have attempted to characterize the rat leukocyte integrin , CD11 / CD18 , by the use of newly generated monoclonal antibodies ( mAb ) WT . 1 ( anti CD11a ) and WT . 3 ( anti CD 18 ) in conjunction with an mAb , OX 42 , reactive with a rat integrin like molecule , with respect to the biochemistry , cellular distribution and function . ^^^ The conclusion that the mAb WT . 1 and WT . 3 specifically recognize the rat CD11a and CD 18 , respectively , was based on : ( a ) their ability to inhibit homotypic aggregation of splenic concanavalin A ( Con A ) blasts ; ( b ) sodium dodecyl sulfate polyacrylamide gel electrophoretic analysis of the antigens recognized ; ( c ) their ability to inhibit binding of Con A blasts to the purified ligand , namely the ICAM 1 antigen and ( d ) their blocking abilities in mixed leukocyte reaction . ^^^ In the rat , CD 18 has an apparent molecular mass of 95 100 kDa and can associate with at least three distinct alpha subunits of 160 170 kDa ( CD11a ) , 140 150 kDa and 120 130 kDa . ^^^ Rat thymocytes , PBL , thoracic duct lymphocytes , monocytes and neutrophils expressed differential levels of CD11a and CD 18 . ^^^ Peritoneal M phi showed virtually no CD11a expression , although CD 18 was expressed at levels similar to those seen on blood monocytes , showing an interesting pattern of LFA 1 expression regulation in this cell lineage . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of the adhesion molecules ( CD11a , b , c / CD18 ) of peritoneal neutrophils , which was determined by an immunofluorescence study , was about four times as much in CD11b and twice as much in CD11c and CD 18 compared to that in blood neutrophils . ^^^ The enhanced adherence activity of peritoneal neutrophils to tumor cells was significantly inhibited by pretreatment of the neutrophils with anti CD11b and anti CD 18 monoclonal antibodies ( mAb ) , but not by pretreatment with anti CD11a or anti CD11c mAb . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
When the role of different a chains was studied , anti alpha L ( CD11a , LFA 1 ) , anti alpha M ( CD11b , Mac 1 ) and anti alpha 10 ( CD11c , p 150 , 95 ) caused marginal inhibition , but the effect of the 3 combined was comparable to that of anti CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of the LFA 1 beta 2 integrin ( CD11a / CD18 ) and ICAM 1 ( CD 54 ) in normal and coeliac small bowel mucosa . ^^^ CD11a ( leucocyte function associated antigen 1 , LFA 1 ) is expressed by most T cells , and is involved in antigen presentation by macrophages via its counter receptor , intercellular adhesion molecule ( ICAM 1 , CD 54 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
It is shown here that induction of suppression by DY follows established activation pathways : ( 1 ) cell adhesion was required because CD11a ( LFA 1 ) mAb blocked suppressor induction ; ( 2 ) CD 4 mAb also blocked , consistent with the involvement of class 2 products in suppressor induction ; ( 3 ) cell proliferation was required because mAb to transferrin receptors , or irradiation , inhibited induction ; and ( 4 ) such proliferation appeared to be interleukin ( IL ) 2 dependent because it was blocked by mAb to IL 2 receptor , and enhanced by exogenous IL 2 but not IL 4 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Moreover , cell adhesion triggered through VLA 4 can not be inhibited by cell preincubation with anti LFA 1 alpha ( CD11a ) , LFA 1 beta ( CD 18 ) , or ICAM 1 ( CD 54 ) mAb as opposed to that mediated by phorbol esters , indicating that it is a LFA 1 / ICAM 1 independent process . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The fimbriated bacteria also bound to CD11a , b , c and CD 18 separated by polyacrylamide gel electrophoresis with sodium dodecyl sulfate and blotted onto nitrocellulose paper . ^^^ Monoclonal antibodies to CD11a , CD11b , or CD 18 inhibited the binding of the bacteria to intact human granulocytes by 55 to 80 % , whereas antibodies against other leukocyte surface antigens were not inhibitory . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
By modifying our microassay , we were able to assess PMN transmigration across T 84 monolayers in the physiological direction ( which , for technical reasons , has not been studied in epithelia ) : transmigration was again largely attenuated by MAb to CD 18 or CD11b ( 86 + / 2 % and 73 + / 3 % inhibition , respectively ) but was unaffected by MAb to CD11a , CD11c . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Increases of CD 10 , CD 13 , and CD11b but not CD11a ( LFA 1 ) were also observed in leukocytes from patients undergoing hemodialysis with cuprophan membranes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The three molecules consist of a specific alpha chain ( CD11a , CD11b , or CD11c ) and share a common beta chain ( CD 18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Whereas expression of CD11b and CD11c is almost exclusively restricted to cells of the myeloid lineage , that of CD11a and CD 18 is panleukocytic . ^^^ Further analysis of this region of the CD11b gene and comparison with the promoters of the CD11a , CD11c , and CD 18 genes should lead to significant insights into the molecular mechanisms by which these genes are regulated during hematopoietic development and upon activation . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Treatment of U 937 cells with PMA markedly increased CD 14 , CD11a , CD11b and CD 18 antigen expression , and slightly increased CD11c expression . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We found that activated mature and immature thymocytes bound maximally at 37 degrees C to IFN gamma treated ICAM 1+ and HLA DR+ TE cells and this TE activated thymocyte binding was inhibited by antibodies to LFA 1 alpha chain ( CD11a ) ( 68 . 1 + / 5 . 6 % inhibition , p less than 0 . 01 ) and ICAM 1 ( 73 . 9 + / 7 . 7 % inhibition , p less than 0 . 05 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Serum free culture of human monocytes in the presence of monoclonal antibodies to the LFA 1 alpha chain ( CD11a ) , CR 3 alpha chain ( CD11b ) or beta chain ( CD 18 ) bound to Sepharose induced the dose dependent production of cell associated interleukin ( IL ) 1 activity and of IL 1 alpha and IL 1 beta antigens , but no release of extracellular IL 1 activity or antigen in the culture medium . ^^^ Induction of cell associated interleukin 1 through stimulation of the adhesion promoting proteins LFA 1 ( CD11a / CD18 ) and CR 3 ( CD11b / CD18 ) of human monocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monocyte adhesion induced by anti CD 14 mAb required neither Fcy gamma R engagement nor cross linking of CD 14 , because adhesion was induced by F ( ab ) ' 2 fragments , as well as by monovalent F ( ab ) fragments of anti CD 14 mAb . mAb to CD11a , CD 18 , and intercellular adhesion molecule 1 ( ICAM 1 ) , but not antibodies to CD11b and CD11c , inhibited monocyte adhesion induced by CD 14 engagement . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The results indicate that antibodies against CD 54 ( intercellular adhesion molecule 1 , ICAM 1 ) , CD11a ( leucocyte function antigen 1 , LFA 1 , alpha chain ) , and CD 18 ( common beta chain of the beta 2 integrin family ) significantly ( by 50 % ) reduce the binding of LGL onto inhibitory target cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The molecules studied included CD 3 , CD45R , UCHL 1 ( CD45RO ) , lymphocyte function associated antigen 1 ( LFA 1 ) ( CD11a , CD 18 ) , intercellular adhesion molecule 1 ( ICAM 1 ) ( CD 54 ) , 4B4 ( CD 29 ) , CD 44 , CD 2 , and LFA 3 ( CD 58 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD27+ B lymphocytes are characterized by the following criteria : ( a ) in terms of physical properties , the CD27+ B cells form a population with an increased cell size combined with a decreased cell density ; ( b ) the CD 27 expression of tonsillar B lymphocytes is postively correlated with mIgA but negatively correlated with membrane IgM / membrane IgD positivity ; ( c ) CD 27 on B cells can be induced selectively by the combination of Staphylococcus aureus plus interleukin 2 , but not by either treatment alone , and ( d ) CD27+ B lymphocytes express high levels of the adhesion structures LFA 1 ( CD11a ) , ICAM 1 ( CD 54 ) , LFA 3 ( CD 58 ) and of the lymphocyte homing receptor CD 44 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Neither 1 . 6 nM PMA , nor immobilized anti CD 5 mAb were mitogenic as a sole stimulus . mAb identifying CD 4 , CD 7 , CD11a , CD 18 , and major histocompatibility complex class 1 molecules were not comitogenic with PMA . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The complementary adhesion molecules LFA 1 ( CD11a , 18 ) / ICAM 1 ( CD 54 ) and LFA 2 ( CD 2 ) / LFA 3 ( CD 58 ) have been shown to be important in T cell interaction with lymphoid target cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies ( MoAb ) Mas 191c , IOT 18 ( directed against the beta chain , 95 kDa , CD 18 ) and IOT 16 , SPVL 7 , MHM 24 ( identificating the alpha chain , 180 kDa , CD11a ) were used , defining the ' CD11a / CD18 ' antibody panel . ^^^ Functional activity comparison of the different anti LFA 1 MoAb showed that the CD11a MoAb significantly inhibited the proliferation of lymphocytes stimulated by the phytohaemagglutinin to various extents , as the LFA 1 alpha determinant identified . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Among the mAb that inhibited B cell DNA synthesis and / or Ig production , only mAb to CD11a , CD 18 , or CD 54 inhibited initial B cell activation as assessed by RNA synthesis . ^^^ Even though mAB to CD11a / CD18 inhibited the capacity of fixed activated T cells to induce B cell responses , the finding that fixed activated CD 18 deficit clones provided help for B cells indicated that expression of the beta 2 family of integrins by T cells was not necessary . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The overall molecular organization of this family of leukocyte integrins was similar to the human counterpart , and consisted of a common beta subunit of 95 kD ( CD 18 ) and non covalently linked alpha subunits of 150 kD ( CD11C ) , 165 kD ( CD11b ) and 180 kD ( Cd11a ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Adhesion was markedly inhibited by MAb against CD 18 and CD11b , with lesser or no inhibition being afforded by MAb against CD11a , CD11c , or ICAM 1 . ^^^ These actions were blocked by actinomycin D or cycloheximide and by MAb against HMC ICAM 1 or phagocyte CD 18 , CD11a , or CD11b , suggesting that cytokines provoked adhesion by inducing HMC ICAM 1 synthesis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Like particular monoclonal antibodies to CD 4 , monoclonal antibodies to epitopes localized at the top of the alpha subunit ( CD11a ) and at the stem of the beta subunit ( CD 18 ) of the lymphocyte function associated antigen 1 ( LFA 1 ) block syncytium formation when added to CD4+ T cells before or shortly after ( 5 min ) cell free HIV 1 is added . ^^^ Syncytium formation is still blocked by CD 4 antibodies when added two hours after virus adsorption , CD11a and CD 18 antibodies are ineffective at this late stage . ^^^ Radio immune precipitation experiments in acutely infected T cells with the appropriate CD11a and CD 18 antibodies suggested a link between CD 18 and CD 4 in the cell lines studied , possibly mediated by the CD3 / TCR complex . ^^^ CD11a / CD18 ( LFA 1 ) epitopes involved in syncytium formation among CD4+ T cells following cell free HIV 1 infection . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The alpha subunits of each of the 3 members , lymphocyte function associated antigen 1 ( LFA 1 ) , macrophage antigen 1 ( Mac 1 ) and p 150 , 95 are designated CD11a , b and c respectively . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Biopsies were taken from 48 h patch test reactions to six structurally unrelated irritants , and frozen sections immunolabeled with monoclonal antibodies to the major histocompatibility complex class 2 antigen , HLA DR , intercellular adhesion molecule 1 ( ICAM 1 ) , and the 88 Kd glycoprotein CD 36 ( OKM 5 ) , as well as to the CD 3 ( T cells ) and CD11a ( lymphocyte function associated antigen 1 , LFA 1 ) antigens . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of CD11a , CD11b , CD11c , CD 15 , CD 18 , CD 10 , CD 24 and B 13 3 membrane antigens was also evaluated . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Regulation of expression of the leukocyte integrin CD11a ( LFA 1 ) molecule during differentiation of HL 60 cells along the monocyte / macrophage pathway . ^^^ The CD11a / CD18 ( LFA 1 ) leukocyte integrin receptor mediates homotypic and heterotypic leukocyte adhesion by binding to one of two defined ligands , ICAM 1 or 2 , on the conjugate cell . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Lymphocytes ( CD 2 positive ) that infiltrated the iris were predominantly helper T cells ( 70 % ) and strongly expressed the lymphocyte function associated antigen 1 ( CD11a , CD 18 ) molecule , the ligand for intercellular adhesion molecule 1 , in four of the seven biopsy specimens . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In particular , QE7 . 3E8 stains lymphoid tissue with a distribution clearly distinguishable from CD 18 antibodies ; it precipitates four bands from a T cell line which does not express the CD11b and CD11c alpha chains , and cross immunoprecipitation with QE7 . 3E8 and a CD11a antibody show that the molecules recognized by these antibodies are not associated . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Effect of anti LFA 1 ( CD11a ) monoclonal antibodies in acute rejection in human kidney transplantation . ^^^ A murine IgG 1 monoclonal antibody , 25 3 ( Immunotech , France ) , directed against the alpha chain ( CD11a ) of the human LFA 1 molecule was used in the treatment of 7 histologically documented first acute rejection in first kidney transplantations under cyclosporine . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast , mAbs directed against CD 8 , CD45R , and CD11a ( LFA 1 , lymphocyte function associated antigen 1 ) failed to evoke lytic activity . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition to the well established role of class 2 antigens in low affinity adhesion provided by interactions between class 2 and CD 4 , recent data indicated that class 2 may also induce adhesion between T and B cells by activating the CD18 / CD11a ( LFA 1 ) adhesion pathway . ^^^ The aggregation was not influenced by mAb against accessory molecules previously shown to be involved directly or indirectly in homotypic aggregation [ CD11a ( LFA 1 ) / CD18 / CD54 ( ICAM 1 ) , CD 58 ( LFA 3 ) / CD2 , BB1 / CD28 , CD 43 , and CD 44 ] . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
While several of the surface structures were differentially modulated by cytokine treatment , it was found that only monoclonal antibodies to the adhesion proteins CD11a and CD 18 were capable of blocking lysis of either cytokine treated or untreated target macrophages . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Surface antigens CD11b , CD11c , CD 2 , and CD 18 on nonadherent NK cells were clustered at the cellular poles by both immunofluorescence and immunogold electron microscopy , whereas CD11a ( LFA 1 ) and CD 56 antigens were distributed diffusely . ^^^ An antibody ( LeuM 5 ) to the CD11c antigen ( p150 . 95 ) gave the highest level of inhibition , and anti CD11a ( LFA 1 ) also was inhibitory , while anti CD 56 ( NKH 1 ) or anti CD11b did not interfere with adhesion to plastic . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast , anti TCR mAb induced proliferation is blocked by anti lymphocyte function antigen 1 ( LFA 1 , CD11a ) mAb and is not demonstrable in PBL from two patients with severe congenital LFA 1 deficiency , not even in the presence of irradiated LFA 1+ PBL . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The possible role ( s ) of the adhesion molecules LFA 1 alpha ( CD11a ) , LFA 1 beta ( CD 18 ) , ICAM 1 ( CD 54 ) , CD 2 ( T 11 , LFA 2 ) , and LFA 3 ( CD 58 ) in the in vitro activation of nickel specific peripheral blood ( PB ) T lymphocytes was studied . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The PMNL migration was highly dependent on the function of both CD11a ( LFA 1 ) and CD11b ( MAC 1 ) PMNL adhesion molecules , since monoclonal antibodies to either inhibited migration by about 80 % . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
However , chemotaxis in response to zymosan activated serum ( ZAS ) and f Met Leu Phe ( f MLP ) , was further impaired on the last day of treatment , which was associated with a marked increase in the expression of the granulocyte adhesion receptors CD11a ( P = 0 . 01 ) , CD11b ( P = 0 . 002 ) , CD11c ( P = 0 . 00015 ) and CD 18 ( P = 0 . 0014 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Finally , of the 3 alpha chains associated with CD 18 , only antibodies to LFA 1 ( CD11a ) partially blocked binding of LAK cells to monocytes and tumor cells . ^^^ It is possible , then , that both CD11a and CD 18 may work in concert to effect the lysis of target cells by LAK cells . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In these studies , we observed opposite effects of antibodies against CD11a ( LFA 1 alpha chain ) or CD 18 ( LFA 1 beta chain ) . ^^^ Here , we determined the effects of anti CD11a and anti CD 18 mAb on proliferation of cloned influenza virus specific T cells . ^^^ Similar differences in effects of anti CD11a and anti CD 18 mAb were observed when proliferation of the T cell clones was induced by immobilized anti TCR mAb . ^^^ When proliferation was induced by influenza virus presented by monocytes as APC , both anti CD11a and anti CD 18 mAb inhibited T cell proliferation . ^^^ However , when EBV transformed B cells were used as APC , neither anti CD11a nor anti CD 18 mAb inhibited proliferation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The CD 18 molecule ( beta chain of CD11a , b , c ) is ubiquitous on the surface of leukocytes and is implicated in a variety of cellular functions . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Antibodies MEM 25 , MEM 83 and MEM 95 are shown to react with a determinant ( s ) present on the isolated larger subunit identified as the CD11a glycoprotein , MEM 48 reacts with the isolated smaller subunit which is identical to the CD 18 glycoprotein . ^^^ Antibodies against subunits of the LFA 1 ( CD11a / CD18 ) leucocyte adhesion glycoprotein . ^^^ Antibodies MEM 30 and MEM 94 recognize probably a determinant in the CD11a / CD18 complex ( i . e . , LFA 1 antigen ) dependent on association of the constituent chains . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The distribution of leucocyte common antigen ( LCA ) protein subspecies and the cellular adhesion molecules LFA 1 ( CD11a ) , ICAM 1 ( CD 54 ) and p 150 , 95 ( CD11c ) has been established within frozen sections of human foetal thymus . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This heterodimeric leucocyte integrin consists of CD11a ( alpha ) subunits non covalently associated with CD 18 ( beta ) subunits coded , respectively , by genes on chromosomes 16 and 21 . ^^^ To determine whether monosomy 21 results in decreased expression of LFA 1 , monoclonal antibodies were used to compare the expression of CD11a and CD 18 on the M 21 LCL with LCL from trisomy 21 ( Down ' s syndrome , T 21 ) , normal controls and a possible case of leucocyte adhesion deficiency . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In normal monocytes , CD 18 and CD11c are concentrated at specific adhesion sites , named podosomes , together with actin , vinculin , and talin , while CD11a , CD11b , CD29 / beta 1 , CDw49d / alpha 4 and CD54 / ICAM 1 retain a diffuse distribution on the cell surface without a selective pattern of localization . ^^^ Further , in these cells CD 18 , CD11a , CD11c , ICAM 1 , and talin , but not vinculin , co localize in homotypic cell junctions , thus showing a close relationship between integrins and talin . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Resting microglia were found to express constitutively CD11a ( LFA 1 ) , CD11b ( Mac 1 , CR 3 ) , CD11c ( P 150 , 95 ; CR 4 ) , and CD 18 ( beta 2 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Antibodies to either CD11a , CD11b or CD11c did not inhibit adhesion when used separately , whereas as a mixture their inhibitory capacity was as strong as that of anti CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In order to evaluate the functions of lymphocyte function antigen 1 ( LFA 1 ) ( CD11a / CD18 ) and Mac 1 ( CD11b / CD18 ) on neonatal neutrophils , we examined neutrophil adhesion to and migration through human umbilical vein endothelial cell ( HUVEC ) monolayers in vitro . ^^^ This migration was significantly inhibited by monoclonal antibodies ( MoAbs ) against LFA 1 ( CD11a ) and Mac 1 ( CD11b ) subunits . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Under all conditions , monocyte adhesion was only partly ( 30 % 40 % ) inhibited by monoclonal antibodies ( mAb ) against the common beta subunit of the leukocyte cell adhesion molecules ( LeuCAM : CD 18 ) and 25 % 30 % by mAb against the alpha subunit of LFA 1 ( CD11a ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We have characterized the binding and phagocytosis of Hc yeasts by human PMN and quantified the PMN respiratory burst in response to this organism . mAb specific for CD11a , CD11b , and CD11c all partially blocked the attachment of unopsonized yeasts to PMN ; a mAb to CD 18 inhibited attachment by greater than 90 % . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Lymphocytes from patients with LAD were exposed to CD 18 expressing retrovirus and enriched for cells that express CD11a and CD 18 ( LFA 1 ) on the cell surface . ^^^ Molecular and functional analyses of these cells revealed ( 1 ) one copy of proviral sequence per cell , ( 2 ) viral directed CD 18 RNA that exceeded normal endogenous levels , ( 3 ) normal quantities of CD11a and CD 18 protein on the cell surface , and ( 4 ) reconstitution of LFA 1 dependent adhesive function . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Reduction of graft failure by a monoclonal antibody ( anti LFA 1 CD11a ) after HLA nonidentical bone marrow transplantation in children with immunodeficiencies , osteopetrosis , and Fanconi ' s anemia : a European Group for Immunodeficiency / European Group for Bone Marrow Transplantation report . ^^^ To prevent graft failure , a mouse monoclonal antibody specific for the CD11a lymphocyte function associated antigen 1 ( LFA 1 ) molecule was infused into the patients . ^^^ The in vivo use of an anti CD11a LFA 1 antibody as an additional immunosuppressive therapy in HLA nonidentical BMT may thus promote engraftment and survival with correction of the primary disease in a significant number of patients with life threatening immunodeficiency and osteopetrosis , but not with Fanconi ' s anemia . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies recognizing CD 18 , CD11a , CD11b , and neutrophil lectin adhesion molecule 1 ( LECAM 1 ) , i . e . , the human homologue of the murine MEL 14 antigen , were used to assess the relative contribution of these glycoproteins to neutrophil endothelial adhesion . ^^^ Under static conditions , the adhesion of neutrophils to IL 1 stimulated human umbilical vein endothelial cell ( HUVEC ) monolayers was inhibited by antibodies to CD 18 , CD11a , and the neutrophil LECAM 1 , and the effect of combining anti LECAM 1 and anti CD11a was almost additive . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Using a quantitative immunofluorescence assay by flow cytometry we could estimate the minimal amounts of antibodies to LFA 1 ( CD11a and CD 18 ) , CD 45 , CD 3 , and CD 5 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Uninvolved keratinocytes were found to stain with anti CD 58 ( leucocyte function associated antigen 3 , LFA 3 ) and there was weak expression of CD11b ( alpha chain of complement C3bi receptor ) and CD11c ( alpha chain of p 150 , 95 molecule ) but not CD11a ( leucocyte function associated antigen 1 , LFA 1 , alpha chain ) on those cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Immunophenotypically , they are highly reactive for CD 4 , phagocytic receptors FcRI , 2 , and 3 , for HLA Dr and CD 31 , as well as for the integrins CD11a , CD11c , and CD 18 , but negative for CD 35 and transferrin receptor epitopes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Few synovial lining cells expressed CD11a ( LFA 1 ) and CD11c ( p 150 , 95 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Immunocytochemical investigations using anti CD11a , CD11b and CD 18 monoclonal antibodies on fresh tissue or , better , peripheral leucocytes are necessary to confirm the diagnosis of this uncommon immunological autosomic recessive inherited disorder . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies IOT 18 ( recognizing the beta chain , 95 kDa , CD 18 ) and SPVL 7 ( recognizing the alpha chain , 180 kDa , CD11a ) were used . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
One , 2E6 , bound a determinant common to all members of the CD11 / CD18 family , most likely the shared 90 kD CD 18 beta chain . 2E6 immunoprecipitated the characteristic beta 2 integrin heterodimers from lymphocytes ( p 180 , 90 ; CD11a ) and macrophages ( p 170 , 90 ; CD11b ) , but from dendritic cells , a p 150 , 90 ( presumably CD11c ) integrin was the predominant species . 2E6 inhibited the binding function of the CD11a and CD11b integrins on B cells and macrophages in appropriate assays , but 2E6 exerted little or no inhibition on the clustering of dendritic cells to T cells early in primary MLR , suggesting a CD11 / CD18 independent mechanism for this binding . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Furthermore , a combination of an intact CD11a and CD 18 antibody does induce a rise in intracellular calcium and production of superoxide . ^^^ Activation of monocytic cells by monoclonal antibodies to the CD11a / 18 ( LFA 1 ) complex : mediation by Fc receptor . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We here describe the in vivo use of a monoclonal antibody to the alpha chain of LFA 1 ( CD11a ) to prevent rejection of T cell depleted allogeneic bone marrow . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Of 15 cases tested for the expression of CD11a and CD 18 lymphocyte function associated ( LFA 1 ) antigens and their ligand ICAM 1 ( CD 54 ) , seven were positive and six negative for the three markers , while the other two cases expressed alternatively the two molecules . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
These antigens were also present on macrophages and macrophage polykaryons both of which also strongly expressed CD11a , b , c , CD 18 , ( LFA family ) , CD 14 , CD 31 , CD 36 , CD 37 , CD 39 and CD 43 antigens . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Immobilized MAb directed at CD 2 , class 1 major histocompatibility complex ( MHC ) encoded gene products or CD11a ( LFA 1 ) dramatically enhanced the response , whereas soluble MAb directed at these determinants did not . ^^^ The data suggest that when anti CD 3 stimulation is suboptimal , responses can be enhanced by MAb to CD 5 or CD 28 ( Tp 44 ) or by immobilized MAb to CD 4 , CD 2 , CD11a ( LFA 1 ) , or class 1 MHC encoded gene products . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Mechanisms of monoclonal antibody facilitated tolerance induction : a possible role for the CD 4 ( L3T4 ) and CD11a ( LFA 1 ) molecules in self non self discrimination . ^^^ Tolerance induction is not a property peculiar to the CD 4 molecule , as similar effects can be elicited with a monoclonal antibody directed to the CD11a ( LFA 1 ) molecule . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Triggering of co mitogenic signals in T cell proliferation by anti LFA 1 ( CD 18 , CD11a ) , LFA 3 , and CD 7 monoclonal antibodies . ^^^ Proliferative T cell responses were elicited in a comitogenic assay when purified mAb against CD 18 , CD11a , LFA 3 , and CD 7 were immobilized onto solid plastic surfaces together with submitogenic doses of mAb against the CD 3 complex . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The CD11 / CD18 family of leukocyte adhesion promoting proteins is comprised of three members , each composed of a shared beta subunit ( CD 18 ) noncovalently associated with unique alpha subunits ( CD11a , CD11b and CD11c respectively ) . ^^^ A vast series of immunostaining procedures was carried out , using monoclonal antibodies anti CD11a , CD11b , CD11c , and CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Exposure to IFN gamma induced expression of both CD11a and CD 18 antigens on epidermal Langerhans cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
These antibodies immunoprecipitated pig proteins corresponding to the human alpha subunits of LFA 1 ( CD11a ) , Mac 1 ( CD11b ) and LeuM 5 ( CD11c ) , and their common beta subunit ( CD 18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Tolerance induction in the adult using monoclonal antibodies to CD 4 , CD 8 , and CD11a ( LFA 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Lymphocyte function associated antigen 1 ( LFA 1 ) is a heterodimeric leucocyte adhesion molecule comprising non covalently associated 95 kD , CD 18 and 180 kD , CD11a subunits . ^^^ Sequential flow cytometric analysis of cell cycle related changes in LFA 1 ( CD18 / CD11a ) expression by trisomy 21 ( Down ' s syndrome ) lymphoblastoid cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Pretreatment of lymphocytes with mAb to the accessory molecules CD 2 , CD 3 , CD 4 , CD 8 , CD11b , or CD11c did not interfere with their response to HD cells . mAb to CD11a ( LFA 1 ) , the alleged ligand of ICAM 1 , inhibited the ICAM 1 but not the HD lectin mediated lymphocyte stimulation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Studies on CD11a and CD 18 molecules with two new monoclonal antibodies : differential myelomonocytic antigen expression of PMA treated HL 60 and U 937 cell lines . ^^^ Biochemical and functional aspects as well as features of cellular distribution of the differentiation groups CD11a and CD 18 were studied in the course of a detailed characterization of two new monoclonal antibodies which recognize the alpha ( GRS 3 ) and beta ( GRF 1 ) chains of the LFA 1 antigen . ^^^ No variation in the expression of LFA complex antigen ( CD11a , b and c , or CD 18 ) was observed on U 937 cells , which on the other hand presented de novo expression of HLA DR and CD 14 antigens . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The leucocyte surface glycoproteins CD11a ( gp 160 , LFA 1 antigen , TA 1 antigen ) , CD11b ( gp 155 , Mac 1 antigen , OKM 1 antigen , Mo 1 antigen ) , CD11c ( gp 130 , Leu M 5 antigen ) , and CD 18 ( gp 90 ) constitute three heterodimers with different alpha chains and a common beta chain . ^^^ Monoclonal antibodies to CD11a , b , or c block adhesion of certain types of leucocytes only , while several antibodies to CD 18 inhibit adhesion in all of them . ^^^ We have now isolated the CD11a , b , c CD 18 leucocyte antigen complex in large amounts from human leucocytes , and produced several new monoclonal antibodies reacting with CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Antibodies to CD11a , CD11b , CD11c , CD 15 , CD 17 , CD 18 , and CD 45 do not activate monocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD11a , CD 18 , and ICAM 1 were demonstrated on up to 80 % of HIV 1 infected H 9 T cells by flow cytometry ; these molecules were not evident on uninfected H 9 . ^^^ Cell surface expression of CD11a and CD 18 , but not ICAM 1 , was increased on HIV infected , as compared to uninfected U 937 and THP 1 monocytoid cells . ^^^ Preincubating the monocytoid cells with anti CD 18 or anti CD11a or preincubating endothelial cells with anti ICAM 1 suppressed these cell to cell interactions . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A majority of both IPP and JPP lymphocytes ( 80 95 % ) expressed the cell adhesion molecules CD11a ( LFA 1 ) and LFA 3 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Antibodies directed towards integrin molecules ( LFA 1 alpha or beta chain , CD11a and CD 18 respectively ) reduced the adherence , others ( anti CR 3 or anti gp 150 / 95 , CD11b and c respectively ) did not influence it . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Inhibition of PMN attachment to IL 1 activated HEC was measured in a quantitative in vitro monolayer adhesion assay , after treatment with mAb directed to ELAM 1 ( mAb H18 / 17 ) , and to CD11a ( mAb L 11 ) , CD11b ( mAb 44 ) , CD11c ( mAb L 29 ) , and CD 18 ( mAb 10F12 ) , alone or in combination . ^^^ CD11 / CD18 directed mAb significantly blocked PMN adhesion to activated HEC ( anti CD11a , 40 + / 3 % ; anti CD11b , 34 + / 4 % ; anti CD 18 , 78+ / 6 % inhibition ) . ^^^ At this time , CD11 / CD18 dependent adhesive mechanisms predominated and a CD11c dependent mechanism became apparent ( anti CD11a , 67 + / 4 % inhibition ; anti CD11b , 45 + / 9 % ; anti CD11c , 26 + / 6 % ; anti CD 18 , 97 + / 1 % ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We focused on the E / T interaction of opsonized cells in the presence of anti CD 18 mAb . mAb directed to the CD11a molecule caused 0 to 30 % inhibition of the lysis of both non opsonized and opsonized cells whereas the mAb antibody directed to the CD11c molecule had no effect . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies to CD 18 and CD11A ( LFA 1 ) distinguish Down ' s syndrome ( trisomy 21 ) from normal lymphoblastoid cells . ^^^ To evaluate the potential of using fluorescence flow cytometry ( FFC ) in the diagnosis of Down ' s syndrome we analysed a series of Trisomy 21 lymphoid cell lines ( LCL ) with a panel of monoclonal antibodies ( MoAb ) to the CD11a and CD 18 subunits of lymphocyte function associated antigen 1 ( LFA 1 ) . ^^^ In pairwise analysis of Trisomy 21 ( T 21 ) and normal LCL with 6 CD 18 and 10 CD11a MoAb we found that T 21 LCL could be distinguished from normal LCL with both types of MoAb , even though only the CD 18 gene is duplicated in Down ' s syndrome . ^^^ Experiments in which CD 18 or CD11a were capped showed that the two subunits co migrate on T 21 and normal LCL , probably as heterodimers . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The leukocyte CD11 / CD18 adhesion molecules ( beta 2 integrins ) are a family of three heterodimeric glycoproteins each with a distinct alpha subunit ( CD11a , b , or c ) and a common beta subunit ( CD 18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To determine the individual roles of CD11a / CD18 ( LFA 1 ) , CD11b / CD18 ( CR 3 , Mac 1 ) and CD11c / CD18 ( p 150 , 95 ) in adhesion of PDB stimulated PMN to unstimulated EC , mAb against the CD 11 chains were used . mAb against CD11a or CD11b each blocked adhesion of PMN to EC by approximately 50 % , but mAb against CD11c had no effect . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies to LFA 1 alpha ( CD11a ) and beta ( CD 18 ) chains were unable to mimic the action of IL 4 on normal B cells in costimulation assays with anti IgM , and did not inhibit normal B cell proliferation in response to IL 4 and anti IgM . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The aggregation of the two types of cell was blocked effectively by the addition of monoclonal antibodies to the alpha and beta chains ( CD11a , CD 18 ) of lymphocyte function associated antigen ( LFA ) , but not by monoclonal antibodies to LFA 3 and the alpha chain of p 150 , 95 ( CD11c ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies ( MAbs ) against platelet glycoprotein gpIIb / IIIa and the leucocyte adhesion molecules LFA 1 , Mac 1 , and gp 150 , 95 alpha chain ( CD11a , b , c ) and beta chain ( CD 18 ) have been tested in normal and leukaemic bone marrows , in different human tissues , and in a patient with leucocyte adhesion deficiency ( LAD ) . ^^^ Platelets and megakaryocytes were reactive with one CD11a ( 25 . 5 . 2 ) , and with no CD11b / c or CD 18 MAbs . ^^^ GpIIb / IIIa was present on the platelets of the patient with LAD , whereas 25 . 5 . 2 , ( CD11a ) bound to his platelets but not to his leucocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The mouse monoclonal antibody 25 3 specific for the alpha subunit of LFA 1 ( CD11a ) has been infused to children undergoing HLA non identical bone marrow transplantation because of lethal inherited diseases or of leukemia in order to prevent graft failure . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The role of lymphocyte function associated antigen 1 ( LFA 1 ) in human T cell chemotaxis was investigated by using mAb specific to the beta chain ( TS1 / 18 ) ( CD 18 ) and alpha chain ( TS1 / 22 ) ( CD11a ) of LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies against CD 2 , CD 4 , CD11a , CD 18 , LFA 3 , ICAM 1 , class 1 and class 2 major histocompatibility complex ( MHC ) inhibited T cell proliferation in this response , whereas antibodies against CD 8 , CD11b , CD11c and CD 16 had no effect . ^^^ Further , antibodies against CD 2 , CD11a , CD 18 , LFA 3 and ICAM 1 inhibited the early dendritic cell T cell clustering event which occurs in this cell interaction . ^^^ However , antibodies against CD11a , CD 18 , ICAM 1 and class 1 MHC may inhibit at either or both cell levels . ^^^ Dendritic cell T cell clustering is mediated by bidirectional binding of LFA 1 ( CD11a and CD 18 ) and ICAM 1 ( involving both molecules on both cell types ) and unidirectional binding of CD 2 and LFA 3 ( involving T cell CD 2 and dendritic cell LFA 3 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
HC commonly expressed the CD11a , CR 4 ( CD11c ) , CD 15 , CD 18 and a number of activation antigens but did not stain with a variety of macrophage specific antibodies . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Aggregation was dependent on active cell metabolism ( inhibited by azide and at low temperatures ) , on the presence of divalent cations ( Mg2+ ) and was inhibited by antibodies to CD 18 but not by antibodies to CD11a ( leukocyte function associated Ag 1 alpha ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The leukocyte adhesion 90 kDa glycoprotein GP 90 ( antigen CD 18 ) is non covalently associated separately with cell surface glycoproteins GP 160 ( antigens CD11a , TA 1 , LFA 1 ) , GP 155 ( antigens CD11b , OKM 1 , MO 1 ) or GP 130 ( antigens CD 11c , Leu M 5 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Effect of mAb against the CD11a c , CD 18 , and GP 84 adhesion molecules on the binding and cytotoxicity of human NK cells was studied . ^^^ The mAb 60 . 3 against CD 18 , the common beta chain associated to CD11a c , strongly inhibited both the binding and cytotoxicity of large granular lymphocytes ( LGL ) against all the target cells tested . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The acquisition of monocyte cytotoxicity was associated with nearly a twofold increase in surface expression of three CD 18 bearing cell surface molecules ( CD11a , CD11b , CD11c ) . ^^^ The inhibition by anti CD 18 MAb could not be attributed to LFA 1 ( CD11a ) alone , suggesting that CR 3 ( CD11b ) and p 150 , 95 ( CD11c ) may also participate in monocyte mediated cytotoxicity . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Similar results were obtained with the CD 18 MAB MHM 23 , and with the CD11a MAB MHM 24 ( LFA 1 alpha ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Primed T cells become independent of the blocking effects of monoclonal antibodies against IL 1 beta and the CD 5 , CD11a ( LFA 1 ) , and CD11c ( p 150 , 95 ) molecules . ^^^ We have compared the requirements of the primary MLR and the responses of alloreactive , primed lymphocytes ( PL ) by inhibition studies using monoclonal antibodies ( MoAb ) directed against ( 1 ) adhesion molecules belonging to the CD 11 cluster of leucocyte antigens ( CD11a , LFA 1 ; CD11b , MAC 1 = CR 3 ; and CD11c , p 150 , 95 ) ; ( 2 ) various T cell related antigens ( CD 2 , CD 4 , CD 5 and CD 8 ) ; and ( 3 ) recombinant IL 1 beta . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Previous investigations of p 150 , 95 ( CD11c ) , the third member of the CD 18 membrane glycoprotein family that includes CR 3 ( Mac 1 or CD11b ) and LFA 1 ( CD11a ) , had demonstrated that solubilized p 150 , 95 bound to iC3b agarose in a manner similar to isolated CR 3 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To assess the possible in vivo significance of these observations we studied the effect of GM CSF on CD11b , CD11a ( LFA 1 ) , and CD11c ( gp 150 , 95 ) expression on granulocytes from nine adult patients with sarcoma who were receiving GM CSF as part of a phase 1 trial . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
MAb recognizing the CTL cell surface molecules CD 3 , CD 8 and LFA 1 ( CD11a ) significantly inhibited CTL mediated lysis of both target cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Whereas noninfected U 937 cells expressed moderate amounts of lymphocyte function associated antigen 1 ( LFA 1 ) ( CD11a ) and minimal amounts of the C3bi receptor ( CD11b ) and p150 / 95 ( CD11c ) , U937 / HIV cells expressed moderate amounts of C3bi receptor and p150 / 95 and showed elevated expression of LFA 1 alpha ( CD11a ) and beta ( CD 18 ) chains . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Conversely , the cell surface expression of the alpha subunit of the lymphocyte function associated antigen 1 or LFA 1 ( CD11a ) was not altered upon cell activation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In the presence of this compound , monoclonal antibody 60 . 3 to GP 90 ( CD 18 , a leucocyte adhesion protein which is non covalently associated to either GP 160 , GP 155 , or GP 130 ) was found to inhibit the adhesion of the four types of leucocytes to a considerable extent , while anti lymphocyte function associated antigen 1 ( LFA 1 ) antibody to GP 160 ( CD11a ) inhibited the adhesion of T and B cells only . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This antibody recognizes GP 90 ( CD 18 ) , a leukocyte surface glycoprotein which is separately and noncovalently associated to either GP 160 ( CD11a ) , GP 155 ( CD11b ) , or GP 130 ( CD11c ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The following molecules were detected in patients before culture : CD 18 ( mean percentage 94 % ) , CD11a ( 94 % ) , CD11b ( 39 % ) , CD 54 ( 23 % ) , CD 58 ( 62 % ) , CD 44 ( Hermes 1 ; 82 % ) , CD 49 d ( VLA 4 ; 80 % ) , CD 25 ( 11 % ) and LECAM 1 ( 62 % ) . ^^^ After stimulation with PHA , there was an increase in the levels of CD 18 ( 2 . 5 fold ) , CD11a ( 2 . 3 fold ) , CD 54 ( 10 . 2 fold ) , CD 58 ( 2 . 5 fold ) , CD 44 ( 2 . 4 fold ) , CD49d ( 3 . 4 fold ) and CD 25 ( 62 fold ) on lymphocytes from both patients and controls . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
FACS analysis revealed the expression of SLex as well as other adhesion molecules such as L selectin , CD11a , CD11b and CD 18 on the cell surface of rat PMN . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LFA 1 like antigen was reactive to mAb 2F12 or HVS6B6 , but not to any of the other five different LFA 1 alpha ( CD11a ) specific or four LFA 1 beta ( CD 18 ) specific mAb . mAb 2F12 immunoprecipitated a 200 kDa membrane protein ( LFA 1 like antigen ) from MKN45 . 16 cells , whereas it precipitated 180 kDa ( LFA 1 alpha ) and 95 kDa ( LFA 1 beta ) proteins from a monocytic cell line ( THP 1 ) under both nonreducing and reducing conditions . ^^^ LFA 1 like antigen was reactive to mAb 2F12 or HVS6B6 , but not to any of the other five different LFA 1 alpha ( CD11a ) specific or four LFA 1 beta ( CD 18 ) specific mAb . mAb 2F12 immunoprecipitated a 200 kDa membrane protein ( LFA 1 like antigen ) from MKN45 . 16 cells , whereas it precipitated 180 kDa ( LFA 1 alpha ) and 95 kDa ( LFA 1 beta ) proteins from a monocytic cell line ( THP 1 ) under both nonreducing and reducing conditions . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Both anti CD11a ( LFA 1 ) and anti CD11b ( MAC 1 ) therapy delay the onset and diminish the severity of experimental autoimmune encephalomyelitis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast , the expression of HLA DR , CD11a and CD 18 was not changed in the course of phagocytosis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition , the treatment induced phenotypic alterations in these cells , as evidenced by the acquisition of the monocyte marker CD 14 and the increase of the alpha chain ( CD11a ) and of the common beta chain ( CD 18 ) of the leucocyte function associated antigen 1 ( LFA 1 ) family antigens . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Furthermore , treatment of the BBECs with antibodies against CD11a ( LFA 1 ) , CD11b ( MAC 1 ) , or ICAM 1 significantly decreased SP induced adherence ( p < 0 . 01 all comparisons ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Studies with MoAbs against adhesion molecules on monocytes revealed that the binding of rIFN gamma stimulated monocytes , but not that of non stimulated monocytes , to rIL 1 alpha stimulated EC was inhibited by about 30 60 % with MoAbs against CD11a , CD11b , CD 18 , L selectin or CD 14 . ^^^ Flow cytometric analysis demonstrated that monocytes stimulated with 500 U / ml rIFN gamma for 24 h showed increased expression of CR 3 ( CD11b / CD18 ) , p 150 , 95 ( CD11c / CD18 ) and Fc gamma RI ( CD 64 ) ; the expression of LFA 1 ( CD11a / CD18 ) , L selectin , CD 14 and VLA 4 ( CD49d / CD29 ) did not change or was slightly reduced . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Infiltrating cells were positive for CD 3 , CD11a , and CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
On analysis of the CD 18 molecular defect in a female Japanese patient with a severe deficiency LAD phenotype , neither CD11a nor CD 18 molecules could be detected on the patient ' s EBV transformed B lymphoblastoid cell line . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This effect appeared to be restricted to CD11b ( CR 3 ) and CD11c ( gp 150 95 ) , because CD11a ( LFA 1 alpha chain ) was not modified . beta 2 Adrenoceptor stimulation was also found to potentiate the effect of IL 4 on CD11b , CD11c , and CD 18 expression . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Freshly isolated LC did not display ICAM 1 ( CD 54 ) , ICAM 2 , LFA 1 ( CD11a ) , and LFA 3 ( CD 58 ) , as detected by double color FACS analysis , using HLA DR expression for LC identification . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A series of cutaneous and mucosal lesions were immunolabeled with monoclonal antibodies to the major histocompatibility complex class 1 ( beta 2 microglobulin ) and 2 ( HLA DR antigens ) , intercellular adhesion molecule ( ICAM 1 ) and glycoprotein CD 36 ( OKM 5 ) as well as CD1a ( Langerhans cells ) , CD 4 , CD 8 ( T cells ) and CD11a ( LFA 1 antigen ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Investigation of biopsies obtained 4 8 weeks after start of treatment revealed a significant fall in the numbers of activated mononuclear cells expressing CD 25 ( IL 2 receptor alpha chain ) , HLA DR , or CD11a ( lymphocyte function associated antigen 1 , LFA 1 alpha chain ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Levels of expression of CD11a , CD 18 , CD49b , CD 58 and CD 71 were unaltered by these cytokines . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The beta 2 integrin CD11a ( Leu CAMa , LFA 1 ) was detected on some B cell clones and seemed to relate to tissue localization of the disease . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Treatment with Abs against CD11a , CD 18 , or CD 54 inhibited not only the homotypic adhesion but also the inhibition of anti IgM Ab induced apoptosis by anti CD 40 Ab . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Aggregation was blocked by monoclonal antibodies to ICAM 1 ( CL18 / 6 ) and CD11a ( R7 . 1 ) and CD 18 ( R15 . 7 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We assessed the expression of the adhesion molecules leukocyte function antigen 1 ( LFA 1 , CD11a ) , intercellular adhesion molecule 1 ( ICAM 1 , CD 54 ) , homing associated cell adhesion molecule ( H CAM , CD 44 ) , and c kit ( stem cell factor receptor ) on the CD34+ progenitor population from the leukapheresis products of 23 patients ( LP CD34+ ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The presence of CD 14 , CD11a , and CD 18 , and possible associated adhesion potential were examined , particularly on microparticles . ^^^ CD 14 , CD11a , and CD 18 were detected by flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Early hematopoietic CD34+ cells express CD 18 , CD11a , CD49d , CD49e , CD 44 , ICAM 1 , and ICAM 3 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Adhesion through the LFA 1 ( CD11a / CD18 ) ICAM 1 ( CD 54 ) and the VLA 4 ( CD49d ) VCAM 1 ( CD 106 ) pathways prevents apoptosis of germinal center B cells . ^^^ Previously , we have shown that the LFA 1 ( CD11a / CD18 ) ICAM 1 ( CD 54 ) and VLA 4 ( CD49d ) VCAM 1 ( CD 106 ) adhesion pathways are involved in FDC B cell interaction . ^^^ Using FDC and B cells derived from human tonsils , we found that only B cells adherent to FDC remain viable : disruption of FDC B cell clusters with mAb against LFA 1 alpha ( CD11a ) , VLA 4 ( CD49d ) , ICAM 1 ( CD 54 ) , or VCAM 1 ( CD 106 ) results in apoptosis of the B cells . ^^^ Together , our data strongly suggest that adhesion of B cells via the LFA 1 ( CD11a / CD18 ) ICAM 1 ( CD 54 ) pathway and VLA 4 ( CD49d ) VCAM 1 ( CD 106 ) pathway contributes to B cell selection . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Constitutive expression of HLA class 2 , LFA 1 alpha ( CD11a ) and ICAM 1 ( CD 54 ) was lower and varied among different cultures , while LFA 2 ( CD 2 ) was absent . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We herein report a case of acute myeloid leukaemia ( AML , FAB : M 0 ) who showed upregulation of T lymphoid antigens ( CD 2 , CD 7 ) and adhesion molecules ( CD11a , CD11b , CD 18 ) on leukaemic cells after in vivo administration of granulocyte colony stimulating factor ( G CSF ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of the adhesion molecules LFA 1 ( CD11a CD 18 ) , Mac 1 ( CD11b CD 18 ) , and LAM 1 on predialysis and intradialysis neutrophils ( PMN ) was analyzed by flow cytometry in 10 chronic hemodialysis patients ( CHD ) and compared with age matched normal controls . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Initial localization of epitopes was accomplished using chimeric proteins constructed by splicing fragments of cDNAs encoding the alpha subunit of LFA 1 ( CD11a ) and the alpha subunit of the closely related leukocyte integrin , Mac 1 ( CD11b ) . ^^^ The location of these residues accounts for the binding specificity of LFA 1 blocking antibodies and identifies particular conserved sequences ( residues 126 150 ) in the 1 domain of CD11a and homologous sequences in other beta 2 integrin alpha subunits that may be important for ligand binding . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Administration of anti tumor necrosis factor alpha ( anti TNF alpha ) or anti CD11a ( LFA 1 ) antibodies to normal adult mice for about 10 days markedly decreased the hydroxyproline content in lung and femur . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Rat thymocytes of the T cell receptorlow ( TcRlow ) CD4+8+ subset which is the target of repertoire selection are heterogeneous with respect to expression of the cell interaction ( CI ) molecules CD 2 , CD 5 , CD11a / CD18 ( LFA 1 ) , CD 28 and CD 44 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Triggering via CD 40 using NIH3T3 CD 40 ligand transfectant ( CD40LT ) cells increased ( > 30 % ) cell surface CD 80 , CD 18 , CD11a , CD11b , and CD11c expression on MM cell lines . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition , the vast majority of LB cells also express the beta 2 ( CD 18 ) and alpha L ( CD11a ) chains of LFA 1 integrin . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Dibutyryl cAMP induced eosinophilic differentiation of EoL 1 cells from 6 9 days after the start of culture with down regulation of CD11a , CD 18 , and CD 49 expression and up regulation of CD11b expression . ^^^ We examined the effect of dibutyryl cAMP ( dbcAMP ) on the expression of LFA 1 ( CD11a / CD18 ) , Mac 1 ( CD11b / CD18 ) , and VLA 4 ( CD49 / CD29 ) and on eosinophilic differentiation of a human leukemia cell line , EoL 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CMC were not recognized by MoAbs to lymphocyte function associated antigen 2 ( LFA 2 ; CD 2 ) , T cell receptor ( TcR ; CD 3 ) , T 4 antigen ( CD 4 ) , LFA 1 alpha chain ( CD11a ) , C3biR alpha chain ( CD11b ) , CR 4 alpha chain ( CD11c ) , LPS R related Ag ( CD 14 ) , 3 FAL / x hapten ( CD 15 ) , Fc gamma RIII ( CD 16 ) , lactosylceramid ( CDw 17 ) , the B cell antigen CD 19 , or CR 1 ( CD 35 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In the gut epithelium , gamma delta cells express less LFA 1 ( CD11a ) , Pgp 1 ( CD 44 ) , and alpha 4 integrin than the corresponding alpha beta cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Protective effects of mAb were also reflected in reductions of retrievable neutrophils in BAL fluids . mAb to rat CD11b and CD 18 but not to rat CD11a suppressed in vitro production of TNF alpha by immune complex stimulated rat alveolar macrophages . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
For the beta 2 integrin subfamily , the cell surface density was increased for CD 18 and CD11a , while the CD11c molecule was expressed exclusively on the HTLV 1 and HTLV 2 infected cell lines . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Skin test sites in delayed pressure urticaria , and urticarial lesions ( > 6 h duration ) of acute and chronic recurrent urticaria also showed marked upregulation of CD11b and CD 18 , and to a lesser extent of CD11a , but this did not strongly correlate with the intensity of the mixed cellular infiltrate . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of other adhesion molecules , LFA 1 alpha ( CD11a ) , LFA 1 beta ( CD 18 ) , Pgp 1 ( CD 44 ) , CD 45 , MEL 14 ( L selectin ) , and VLA 4 alpha ( CD49d ) , were all increased as a result of anti CD 2 treatment , whereas CD 25 ( IL 2R ) , CD 48 ( CD 2 ligand ) , and ICAM 1 ( CD 54 ) remained unchanged . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
When complexed with CD 18 , all CD11a chimeras bound ICAM 1 at levels comparable to wild type CD11a / CD18 , indicating that the residues in these chimeras which differ in human and murine 1 domains may not play a critical role in LFA 1 binding to ICAM 1 . ^^^ Identification of amino acids in the CD11a 1 domain important for binding of the leukocyte function associated antigen 1 ( LFA 1 ) to intercellular adhesion molecule 1 ( ICAM 1 ) . ^^^ Using human / murine chimeras of the 1 domain of the LFA 1 alpha subunit ( CD11a ) , we recently identified the epitopes recognized by eight monoclonal antibodies against CD11a that inhibit LFA 1 binding to ICAM 1 . ^^^ In this report , we determined that replacement of the entire human 1 domain with the entire murine 1 domain in CD11a completely abrogated LFA 1 binding to human ICAM 1 without affecting the gross conformation or heterodimer formation of LFA 1 , as assayed by antibody binding . ^^^ Substitution of alanine for proline at position 192 in the human CD11a 1 domain abrogated adhesion of LFA 1 to ICAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Frozen tissue samples were stained by a labeled avidin biotin technique using primary antibodies to LFA 1 ( CD11a ) , CD 2 , CD 4 , CD 8 , CD 20 , CD 68 , HLA DR , ICAM 1 ( CD 54 ) , and VCAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A low proportion of TMF ( 10 20 % ) expressed CD11a ( LFA 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Furthermore , the aggregation induced by rapamycin was blocked by antibodies to the alpha ( CD11a ) or beta ( CD 18 ) subunits of the integrin , LFA 1 , or to its ligands , ICAM 1 and ICAM 2 , and did not occur in LFA 1 deficient YAC mutants . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The ability of inactivated viruses , bacteria , protozoa and fungi to modulate the expression of CD 14 , CD49d , CD49f , CD11a ( LFA 1 ) , and CD 54 ( ICAM 1 ) molecules in unprimed bone marrow derived mononuclear phagocytes ( BMM phi ) was investigated by means of flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Some mAbs recognizing the LFA 1 alpha chain ( CD11a ) or LFA 1 beta chain ( CD 18 ) inhibited the binding of YTA 1 to peripheral blood mononuclear cells . ^^^ YTA 1 bound to COS 7 cells co transfected with CD11a and CD 18 cDNAs , but not to untransfected cells . ^^^ Reactivities of YTA 1 to K 562 cells transfected with LFA 1 alpha and beta ( CD11a / CD18 ) cDNAs and to CHO cells transfected with Mac 1 ( CD11b / CD18 ) or p 150 , 95 ( CD11c / CD18 ) cDNAs strongly suggest that YTA 1 recognizes either LFA 1 alpha or an epitope formed by a combination of LFA 1 alpha and beta . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast to monoclonal antibodies to CD 18 , none of the monoclonal antibodies significantly increased the risk of abscess formation by S . aureus , although inhibition of CD11a increased the rate of abscess formation by P . aeruginosa . . ^^^ The following studies were carried out to determine whether monoclonal antibodies to other adhesion molecules , including L selectin ( CD62L ) , and CD11a ( the alpha chain of LFA 1 ) , also increase susceptibility to infection . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To delineate the adhesion proteins involved in the cell cell interactions , assays were performed in the presence of specific blocking monoclonal antibodies to eosinophil CD 18 , CD11a , or CD11b , and REC ICAM 1 molecules . ^^^ In contrast , antibodies to CD 18 , CD11a , and CD11b significantly decreased ( P < 0 . 01 ) eosinophil adhesion , thus demonstrating pivotal roles for the CD11 / CD18 ( beta 2 ) integrins , but not necessarily for ICAM 1 , in interactions between the REC and eosinophils . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
These results suggest that neutrophil endothelial adhesive interactions , which occur via CD11a / CD 18 and CD11b / CD18 dependent interactions with intercellular adhesion molecule 1 , and oxygen derived free radicals produced by neutrophils are implicated in the production of aspirin induced gastric mucosal injury . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This study examined the relationship between exercise induced changes in the concentration of circulating immunocompetent cells and their surface expression of adhesion molecules : L selectin ( CD62L ) and three beta 2 integrins [ LFA 1 ( CD11a / CD18 ) , Mac 1 ( CD11b / CD18 ) , and p150 / 95 ( CD11c / CD18 ) ] . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
With regard to surface marker profile , the established cells were positive for CD11a , CD 13 , CD 18 , CD 33 , CD 34 , CD41b , CD42b , CD 54 , and c kit antigens , but negative for HLA class 2 antigen and glycophorin . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The beta 2 integrin consists of lymphocyte function antigen 1 ( LFA 1 , CD11a / CD18 ) which binds to the major ligand intracellular adhesion molecules 1 and 2 ( ICAM 1 and ICAM 2 ) , Mac 1 ( CD11b / CD18 , ligand iC3b ) and p 150 , 95 ( CD11c / CD18 , ligand iC3b ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
IL 2 stimulation of NK cells resulted in an increase in the expression of adhesion molecules involved in binding of NK cells to bone marrow fibroblasts ( BMF ) and extracellular matrix ( ECM ) proteins including the beta 1 chain CD 29 , alpha chains of VLA 4 and 5 , beta 2 chain CD 18 and alpha L chain CD11a . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Ia , CD 54 , CD11a and CD 18 ) were not affected . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies against CD 54 ( ICAM 1 ) and CD11a ( LFA 1 ) prevent and inhibit endotoxin induced uveitis . ^^^ We studied the effect of monoclonal antibodies ( mAbs ) against CD 54 ( intercellular adhesion molecule 1 ; ICAM 1 ) and CD11a ( lymphocyte function associated antigen 1 ; LFA 1 ) on the prevention and treatment of endotoxin induced uveitis ( EIU ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Previous studies have shown that lymphocyte function associated antigen 1 ( LFA 1 ) molecules containing the human alpha ( CD11a ) and human beta ( CD 18 ) subunits but not the murine alpha and human beta subunits can bind to human intercellular adhesion molecule 1 ( ICAM 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We show that IFN beta downregulates both basal and IFN gamma induced expression of VLA 4 ( very late activation antigen 4 ) antigen on monocytes , but has no effect on the expression of CD11a , CD11b , CD11c , L selectin , CD 18 , ICAM 1 , beta 1 integrin or CD 44 on monocytes or ICAM 1 on EAhy 926 cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
On day 6 , most T cells coexpressed the CD11a , CD 18 , CD 54 , CD45R0 antigens and consisted of activated ( CD25+ ) CD4+ and CD8+ cells in nearly equal proportions . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Interestingly , all CD8+ T cells , although bearing different 5 beta T cell receptors , expressed marked signs of activation , i . e . , CD45R0 , CD 38 and major histocompatibility complex class 2 molecules , and also high amounts of CD11a and CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The MoAb OKM 1 against CD11b , which blocks fibrinogen binding to CD11b / CD18 as well as the MoAbs IOT 16 and IOT 18 directed against CD11a and CD 18 , respectively , had no effect . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD 29 , CD 18 , and CD11a were also present on each of these cell lines . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The level of expression of CD 9 , but not that of CD11a , CD 18 , CD 19 , CD 44 , or CD 54 , was found to correlate with the level of aggregation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A single administration of 500 micrograms of an antibody to the adhesion molecule , leucocyte function associated antigen ( LFA 1 , CD11a ) , prevented all thyroid allograft rejection for at least 70 days . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Cord blood T cells expressed normal percentages of the cellular adhesion molecules , CD11a , CD 18 and LFA 3 ; however , the antigen density of each of these molecules was less than that found on adult T cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Among various molecules known to provide costimulatory function , the expression of CD 54 ( ICAM 1 ) and CD11a / CD18 ( LFA 1 ) on MAIDS B cells was increased , whereas that of CD 2 , heat stable Ag ( CD 24 ) , CD 80 ( B 7 1 ) , and CD 86 ( B 7 2 ) was unchanged from normal . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A panel of 21 alpha subunit ( CD11a ) and 10 beta subunit ( CD 18 ) anti LFA 1 mAbs was screened for ability to activate LFA 1 . ^^^ The epitope recognized by mAb MEM 83 was distinct from that recognized by mAb NKI L 16 , an anti CD11a mAb previously reported to induce LFA 1 activation , in that it was constitutively present on freshly isolated peripheral blood mononuclear cells and was not divalent cation dependent for expression . ^^^ Using an in vitro translated CD11a cDNA deletion series , we have mapped the MEM 83 activation epitope to the `` 1 ' ' domain of the LFA 1 alpha subunit . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Epstein Barr virus ( EBV ) negative and EBV carrying Burkitt lymphoma ( BL ) lines that remain phenotypically similar to the in vivo tumor cells ( operationally defined group 1 BLs ) express high levels of CD 10 and CD 77 , and lack immunoblastic markers such as CD 23 and CD 39 , and the cell adhesion molecules CD11a , CD 18 , CD 54 and CD 58 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The beta 2 integrins are composed of a common 95 kD beta subunit ( CD 18 ) and one of three possible alpha subunits : CD11a , CD11b , or CD11c . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
All cell lines from MS and controls expressed increased levels of LFA 1 ( CD11a ) , LFA 2 ( CD 2 ) , LFA 3 ( CD 58 ) , ICAM 1 ( CD 54 ) , and VLA 4 ( CDw49d ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Activation of human neutrophil LFA 1 ( CD11a ) by leukotriene B 4 . ^^^ The involvement of LFA 1 in LTB 4 induced HA of neutrophils was suggested initially by the inhibitory effect of monoclonal anti CD 18 and anti CD11a antibodies . ^^^ The binding to neutrophils of a monoclonal anti LFA 1 antibody ( NK 1 L16 ) specific for an activation epitope of CD11a was increased a maximum of 28 fold and sixfold , respectively , after 1 and 5 min of preincubation with 10 nM LTB 4 and fivefold after 5 min with PMA . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Activation was not seen when cells were attached to the substrates using antibodies directed to other cell surface proteins including CD 71 ( transferrin receptor ) , CD 7 , and CD11a ( LFA 1 ) , demonstrating the specificity of activation for immobilized anti CD 3 antibodies . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In this study , seven mAb directed against human CD11a and two mAb directed against human CD 18 , the alpha and beta chains of the leukocyte functional Ag 1 molecule , respectively , were analyzed for their ability to inhibit several leukocyte functional Ag 1 mediated interactions . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies to both the alpha chain ( CD11a ) and the beta chain ( CD 18 ) of LFA 1 induced Ca2+ mobilization to different levels , suggesting epitope specificity for activation potential . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
However , no statistically significant differences were found between PMNL from DS children and those from controls in phagocytosis , oxidative burst , and expression of the markers CD11a , CD11b , CD 16 , and CD 18 . ^^^ Furthermore , no overexpression of CD11a and CD 18 was present as a consequence of gene overdosage in PMNL from DS children . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Thirteen patients were investigated using the following monoclonal antibodies ( mAbs ) : CD 2 , LFA 3 ( CD 58 ) , ICAM 1 ( CD 54 ) , LFA 1 ( CD11a ) , the alpha / beta and gamma / delta T cell receptor , pan T cells and broadly distributed monocyte / macrophage ( m / m phi ) [ Fc gamma RII ( CD 32 ) , 25F9 , RM3 / 1 ] . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast , Western blot analysis revealed no obvious qualitative abnormality in either CD11a ( the alpha chain of LFA 1 ) or CD 44 on CLL cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Of note , anti CD 14 mAb decreased the expression of CD 54 , but not that of CD11a or CD 18 , on monocytes , suggesting that inhibition of the soluble anti CD 3 induced IFN gamma production by anti CD 14 mAb might be a result from decrease in CD11a / CD18 CD 54 mediated interactions between CD4+ T cells and monocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Flow cytometry analysis revealed that these cells express CD 45 , CD 56 , CD 2 , CD 7 , CD11a , CD 18 , CD 69 and the intermediate affinity ( p 70 ) IL 2 receptor ( IL 2R ) but not CD 57 , CD 16 , CD 3 , CD 4 , CD 5 , CD 8 , CD45RA , CD 25 , or the high affinity p 55 IL 2R . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Exposure of NK cells to IL 2 or of EC to IL 1 , TNF , or IFN gamma augmented transendothelial migration . mAb directed against CD 18 and CD11a inhibited binding and migration of NK cells across resting or IL 1 activated EC , whereas anti CD11b and c mAb did not . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Treatment of leukocytes with phorbol myristate acetate ( PMA ) caused significant increases in the expression of adhesion molecules , CD11a , CD11b , CD11c , and CD 18 , on the surface of the leukocytes . ^^^ Monoclonal antibodies against CD11a , CD11b and CD 18 , and ICAM 1 , an adhesion molecule in the side of endothelial cells , abolished significantly the endothelial cell injury induced by PMA stimulated leukocytes . ^^^ The monoclonal antibodies against CD11a , CD11b , CD 18 , and ICAM 1 also showed inhibitory effects on the increase in intracellular fluorescence intensity of the endothelial cells exposed to PMA stimulated leukocytes . ^^^ Both the early increase in peroxide production and late cell lysis were abolished by specific antibodies against CD11a , CD11b , CD 18 , and ICAM 1 , but not CD11c . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast , monoclonal antibodies against CD11a and CD 18 significantly inhibited the increased conversion of XD to XO induced by PMA activated neutrophils . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Flow cytometric analysis revealed higher expression of CD11a , CD11b , CD 18 and CD49d on NK LAK compared with T LAK . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD 18 cDNA carrying the abnormalities were cotransfected with normal CD11a or CD11b cDNA into COS cells . ^^^ Expression of the LFA 1 ( CD11a / CD18 ) and Mac 1 ( CD11b / CD18 ) antigens on COS cells was not detected , suggesting that these two mutations are sufficient to account for LAD . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In CDC stage B / C patients , whose monocytes ' ability to phagocytose bacteria and migrate across confluent endothelial monolayers was diminished , surface expression of CD49e and CD62L and the percentage of monocytes expressing CD 18 , CD11a , CD 29 , CD49e , CD 54 , CD 58 , CD 31 , and HLA 1 were significantly decreased . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We show that the well established differences in kinetics of mitogen and antigen induced T cell proliferation in vitro is paralleled by differential kinetics in the expression of the T cell adhesion and activation antigens leukocyte function associated antigen 1 ( LFA 1 ; CD11a / CD18 ) , interleukin 2 receptor ( IL 2R ; CD 25 ) , and intercellular adhesion molecule 1 ( ICAM 1 ; CD 54 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
According to previous findings , basophils express CD 9 ( p 24 ) , CD11a ( LFA 1 alpha chain ) , CD11b ( C3biR ) , CD11c ( CR 4 ) , CD 13 ( aminopeptidase N ) , CDw 17 ( lactosylceramide ) , CD 18 ( beta chain of beta 2 ) , CD 25 ( IL 2R alpha chain ) , CD 26 ( dipeptidylpeptidase ) , CD 31 ( PECAM ) , CD 35 ( CR 1 ) , CD 38 ( T 10 ) , CD 43 ( leukosialin ) , CD 44 ( Pgp 1 ) , CD 45 ( pan leukocyte Ag ) , and CD 63 ( basophil activation Ag ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of adhesion molecules in vitro was differential : the number of cells carrying CD11c , CD 29 , CDw49b , CDw49d , CDw49e , CDw49f , CD 54 , CD 56 and ELAM 1 being significantly overrepresented among the nickel induced lymphoblasts whereas the number of blasts carrying CD 44 was underrepresented and those of CD11a , CD 18 , CD 58 and LAM 1 remained unchanged . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
IL 8 selectively induced expression of HLA DR antigen , but had no effect on the expression of other cell surface antigens ( CD11a , CD 18 , CD 36 and CD 54 ) . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Adhesive glycoproteins CD11a and CD 18 are upregulated in the leukocytes from patients with ischemic stroke and transient ischemic attacks . ^^^ The purpose of the present pilot study is to delineate whether the expression of leukocyte adhesion molecules , CD11a and CD 18 , are upregulated in patients with ischemic stroke and transient ischemic attack . ^^^ Using immunofluorescence phenotyping and flow cytometry , leukocyte membrane expression of CD11a and CD 18 were measured within 72 h after onset of ischemia . ^^^ No difference of CD11a and CD 18 IF was detected between stroke and TIA groups . ^^^ Follow up measurement of CD11a and CD 18 showed a trend of decrease , but CD11a IF remained significantly elevated compared with the control group ( p < 0 . 017 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Activities found in four lots each of horse ATG ( ATGAM , Upjohn ) , rabbit and horse ATG ( thymoglobulin and lymphoglobulin , Merieux ) , horse ALG ( Minnesota ) , and rabbit ATG ( Fresenius ) have been compared for CD 2 , CD 3 , CD 4 , CD 5 , CD 7 , CD 8 , CD11a , CD 18 , CD 28 , CD 44 , CD 45 , and TCR alpha / beta antigens . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition , these cells were weakly positive for CD11b ( Mac 1 ) and CD 54 ( ICAM 1 ) , but were negative for lymphocyte specific CD11a ( LFA 1 ) and CD11c ( p 150 , 95 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Immunohistochemistry was performed using monoclonal antibodies against macrophage markers ( ED 1 , CD 4 , RT 1 B , and ED 2 ) , chains of the beta 2 integrins ( CD 18 , CD11a , and CD11b ) , T and B cell markers ( CD 8 , T cell receptor , interleukin 2 receptor , and MRC OX 33 ) , and markers of mesangial cell proliferation ( proliferating cell nuclear antigen , alpha smooth muscle actin ) . ^^^ Second , the presence of CR 3 ( i . e . , CD11b and CD 18 ) and LFA 1 ( i . e . , CD11a and CD 18 ) on the macrophage infiltrate indicates that both ligands are important for cells to enter the mesangium and periglomerular areas . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In this study we evaluated the possible expression of CD11a and CD 18 antigens on thyrocytes of patients with Hashimoto ' s thyroiditis and on thyrocytes of patients with Graves ' disease and simple goiter as controls ; we used both alkaline phosphatase immunostaining and indirect immunofluorescence on cryostatic tissue sections . ^^^ The results showed that LFA 1 ( both CD11a and CD 18 ) positivity on thyroid follicles may occur in glands of patients with Hashimoto ' s disease , with a pattern very similar to that of CD 54 : this was observed in five of seven specimens . ^^^ Follicular thyroid cells of autoimmune thyroiditis may coexpress ICAM 1 ( CD 54 ) and its natural ligand LFA 1 ( CD11a / CD18 ) . ^^^ The leukocyte functional associated antigen 1 ( LFA 1 ) intercellular adhesion molecule 1 ( CD11a CD18 / CD54 ) intercellular adhesion system plays a crucial role in several immunologic phenomena , including adhesion between lymphocytes and epithelial cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
After a continuous infusion of a nonlethal dose of E . coli LPS ( . 5 mg / kg ) or TNF ( 6 . 0 10 10 ( 5 ) units ) into rats , PMN were recovered by centrifugal elutriation and discontinuous density gradient centrifugation from the liver ( LPS treated ) and whole blood ( LPS and TNF treated ) and compared for CD11b / c , CD11a , and CD 18 upregulation and their capacity for basal and agonist stimulated O 2 production . ^^^ Immunofluorescence flow cytometry studies of rat whole blood PMN demonstrated that , upon LPS infusion , there was a time dependent upregulation of CD11b / c and CD 18 , but not of CD11a . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Hi and lo CD 43 MO expressed comparable amounts of CD 14 , CD 45 , and intercellular adhesion molecule 1 ( CD 54 ) ; hi CD 43 MO expressed somewhat more lymphocyte function associated antigen 1 alpha chain ( CD11a ) and CD 18 than their lo CD 43 MO counterparts . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
However , as determined by flow cytometry , pentoxifylline did not alter TNF alpha induced upregulation of intercellular adhesion molecule 1 or vascular cellular adhesion molecule 1 on endothelioma cells nor did it affect constitutive CD11a , CD 18 , or alpha 4 integrin expression on T lymphoma cells , suggesting that rather than affecting quantitative expression of these adhesion molecules , pentoxifylline might modulate their avidity . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The beta subunit gene ( CD 18 ) is constitutively expressed on all leukocytes , however , the alpha subunit genes for LFA 1 , Mac 1 and p 150 , 95 ( CD11a , CD11b and CD11c , respectively ) show cell and developmental stage specific expression . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Double fluorescence activated flow cytometry was used to assess HML 1 expression with T cell subtype antigens ( CD 3 , CD 4 , CD 8 ) or activation markers interleukin 2 receptor ( IL 2R ) ( CD 25 ) , HLA DR , and lymphocyte function associated antigen ( LFA 1 ) ( CD11a ) were assessed by flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In the present study we investigated the membrane expression of selectin ligands ( CD15 / Le ( 10 ) , CDw65 / VIM2 , CD15s / sLe ( 10 ) , beta 2 integrins ( CD11a / LFA 1 , CD11b / Mac 1 ) and CD 45 phosphatase isoforms ( CD45RA , CD45O ) on leukaemic cells from 28 patients with acute myeloid malignancies cultured with and without all trans retinoic acid ( ATRA ) . ^^^ In spite of the well recognized expression of CD11a throughout all stages of normal myeloid differentiation , APL blast cells were found to virtually lack LFA 1 expression . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Surface expression of the beta 2 integrin chains ( CD11a , CD11b , CD11c and CD 18 ) , and the beta 1 integrin chains ( CD49b , CD49d , CD49f and CD 29 ) , as well as that of members of the immunoglobulin superfamily ( CD 2 , CD 54 , CD 56 and CD 58 ) , were analyzed by one or two color flow cytometry . ^^^ Fluorescence values for CD 2 , CD11a , CD 18 and CD 56 were higher in LAL than in PBL . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The anergized CD8+ T cell subset expressed lower levels of the alpha ( CD11a ) chain of the cell adhesion molecule lymphocyte function associated Ag 1 ( LFA 1 ) and failed to mediate cytotoxicity , but retained the capacity to proliferate , express IL 2R , produce IFN gamma , and express granzyme mRNA , which imply a partial defect in TCR transduced signals . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The lack of susceptibility to HIV 1 infection in human hematopoietic progenitor TF 1 cell line correlates with the absence of LFA 1 ( CD11a ) surface adhesion molecule . ^^^ The only difference observed concerned the LFA 1 CD11a protein that has already been shown to be necessary for cell fusion in HIV 1 infected T 4 lymphocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Fifty to ninety percent of lung and BAL T cells from vehicle sensitized or OA sensitized and challenged mice expressed the adhesion molecules CD11a ( LFA 1 ) , CD 54 ( ICAM 1 ) , and CD49d ( VLA 4 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Using flow cytometry analysis , the % s of CD 18 , CD11a and CD11b positive cells and the absolute numbers of fluorescent molecules were determined . ^^^ In this study , we assessed the LFA 1 ( CD18 / CD11a ) and CR 3 ( CD18 / CD11b ) expression on peripheral polymorphonuclear leukocytes ( PB PMN ) and crevicular fluid polymorphonuclear leukocytes ( CF PMN ) , by subjects with a healthy periodontium ( n = 7 ) , gingivitis ( n = 8 ) , early onset periodontitis ( n = 17 ) and adult periodontitis ( n = 8 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The aim of the present study was to compare the preventive effect of a nondepleting monoclonal antibody specific for the LFA 1 alpha chain ( CD11a ) on the rejection of bone marrow , vascularized cardiac , and nonvascularized skin grafts in the same haplotype disparate mouse strain combination . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In vitro binding of MNC from naive animals to chronically rejecting allografted kidneys generally confirmed the immunohistological observations , peaking at 12 wk ; this binding was significantly inhibited by mAbs against specific adhesion molecules ( CD11a , CD 18 , and ICAM 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies against ICAM 1 and LFA 1 ( CD11A ) induce specific tolerance to peripheral nerve allograft in rats . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Beta 2 ( CD 18 ) mutations abolish ligand recognition by 1 domain integrins LFA 1 ( alpha L beta 2 , CD11a / CD18 ) and MAC 1 ( alpha M beta 2 , CD11b / CD18 ) . ^^^ Recombinant alpha L beta 2 ( LFA 1 , CD11a / CD18 ) and alpha M beta 2 ( MAC 1 , CD11b / CD18 ) were expressed on COS cells , and function was assessed by adhesion to ICAM 1 or iC3b , respectively . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Anti leucosialin induced aggregation of HMC 1 cells was completely inhibited by mAb against CD11a ( LFA 1 ) and CD 18 ( beta 2 chain ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A monoclonal against the beta chain of LFA 1 ( CD 18 ) cross reacted strongly , but there was only a very poor cross reaction with a monoclonal against the alpha chain of CD11a . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
During the third trimester fetal expression of CD 18 , CD11b , and CD11c on neutrophils and CD11b on monocytes was lower , and maternal expression of CD11a on neutrophils and CD 18 , CD11a and CD11c on monocytes was higher than were the control adult values . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Prolonged incubation of Farage cells with IL 4 for 6 8 days led to increased expression of CD11a ( LFA 1 ) CD 39 , CD 40 , and to disappearance of CD 21 and CD 38 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The alpha L beta 2 ( CD11a / CD18 ) integrin LFA 1 ( lymphocyte function associated antigen 1 ) mainly contributes to the firm arrest of leucocytes on the endothelium . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The extract induced adhesion was significantly diminished by monoclonal antibodies ( MAb ) directed against either CD11a , CD11b , or CD 18 on neutrophils , and by MAbs against intercellular adhesion molecule 1 ( ICAM 1 ) , but not E or P selectin , on endothelial cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
T cell adhesion to purified ICAM 3 was completely inhibited by cell pretreatment with mAbs to the LFA 1 alpha ( CD11a ) or the LFA beta ( CD 18 ) integrin chains . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD11a is the alpha subunit of the leucocyte adhesion and costimulation molecule LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Efficacy of antibodies to adhesion molecules , CD11a or CD 18 , in rabbit models of uveitis . ^^^ Antibodies to two different leukocyte molecules , CD11a and CD 18 , and antibodies to the endothelial ligand for CD11a / CD18 , ICAM 1 ( intercellular adhesion molecule 1 , CD 54 ) , were studied in inflammation after intravitreally injected interleukin 1 , intravitreally injected endotoxin , or an ocular reversed passive Arthus reaction . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Because leukocyte integrin expression on PMNs affects transendothelial migration , we also compared surface expression of CD 18 , CD11a , and CD11c on PMNs from the two age groups . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The percentage of BAL lymphocytes showed a relationship with the expression of macrophage antigens in 11 out of 15 antigens studied ( all except adhesive molecules CD11a , CD11c , CD 18 and the antigen 25F9 present on mature macrophages ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Three out of three different MoAbs against the beta chain of the LFA 1 molecule ( CD 18 ) and two out of three MoAbs against the alpha chain ( CD11a ) had an enhancing effect on T cell proliferation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The monoclonal antibodies against CD11a , CD11b , CD 18 , and ICAM 1 showed almost complete inhibition of the increase in intracellular peroxide levels of the endothelial cells exposed to PMA stimulated leukocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Pretreatment of effector cells by anti LFA 1 alpha ( CD11a ) and anti LFA 1 beta ( CD 18 ) MAbs significantly inhibited cytolysis of all types of EGF R+ tumor cells , while anti CD 2 and anti VLA 4 MAbs were virtually ineffective . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The cryostat sections were stained with adenosine triphosphatase as well as with the indirect immunoperoxidase technique employing murine monoclonal antibodies to HLA DR , ICAM 1 , CD 1 , CD11a , and CD 18 . ^^^ RESULTS HLA DR and ICAM 1 expression by epidermal cells , combined with perivascular accumulation of mononuclear cells with CD11a and CD 18 expression , was observed in all sites injected with IFN gamma . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
That manganese was exerting its effect via an LFA 1 dependent mechanism was confirmed using monoclonal antibodies to CD11a which negated the increased conjugation frequency due to manganese . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Anti LFA 1 ( CD11a ) monoclonal antibody interferes with neonatal induction of tolerance to alloantigens . ^^^ For this purpose , BALB / c mice neonatally injected with F 1 cells were treated from day 1 up to day 15 with a non cytotoxic anti LFA 1 ( CD11a ) mAb . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
At optimal doses , anti CD11a or anti CD 18 mAb completely inhibited Th 1 proliferation induced by either LC or DC . ^^^ In marked contradistinction , the capacity of LC to present KLH to our Th 2 clones was resistant to treatment with the same mAb against ICAM 1 , CD11a or CD 18 . ^^^ Expression of the adhesion molecules ICAM 1 and LFA 1 ( CD11a / CD18 ) on mouse epidermal Langerhans cells ( LC ) and on spleen dendritic cells ( DC ) from BALB / c mice was examined by staining with specific mAb and was evaluated by flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In the current study we used immunogold ultrastructural techniques to identify the exact sites of expression of ICAM 1 ( CD 54 ) in the glomerulus and the expression of CD11a and CD 18 by infiltrating glomerular leukocytes in the first 24 hours of accelerated anti GBM disease in rats . ^^^ These adherent and migrating leukocytes expressed abundant surface CD11a and moderate CD 18 particularly at their sites of adhesion to glomerular endothelium . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ In contrast PMNL expressed only very sparse surface CD11a , suggesting that another beta 2 integrin , Mac 1 , which shares a common beta chain with LFA 1 may be the more important PMNL counter receptor for ICAM 1 in the glomerulus . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Analysis of beta 2 integrins on SLP cells showed not only an increased cell surface density of both CD 18 and CD11a but also differential expansion of CD8+ T cells coexpressing CD 18 ( 54 . 0 + / 10 . 3 % ) , CD11a ( 53 . 7 + / 8 . 1 % ) , and S6F1 , an epitope of CD11a , ( 65 . 3 + / 7 . 8 % ) on Day 8 compared with Day 0 ( 20 . 0 + / 2 . 5 % , 19 . 3 + / 1 . 9 % , and 38 . 0 + / 7 . 0 % , respectively ) . ^^^ Monoclonal antibodies to CD 18 and CD11a inhibited SLP by 55 + / 6 . 3 % in HTLV 2 infected persons in a dose dependent manner . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
On the other hand , conditioned medium from hypoxia incubated HUVEC failed to activate PMN , as determined by the lack of PMN calcium concentration increase , the failure of superoxide anion production enhancement , as well as the absence of effects on the integrin CD 18 , CD11a , and CD11b expression . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Anti lymphocyte function associated antigen 1 ( anti LFA 1 ) ( CD11a ) , anti very late antigen 4 ( anti VLA 4 ) ( CD49d ) and anti CD 18 block binding of mitogen activated lymphocytes to brain endothelium and the effects of anti LFA 1 and anti VLA 4 are additive . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Specific monoclonal antibodies directed against CD11a , CD 18 , and VLA 4 were able to block adherence of lymphocytes to stimulated BBEC . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Neutrophil integrin expression ( CD 18 , CD11a , CD11c ) , aggregation , and transendothelial migration were studied in vitro . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD11a , CD11b , CD11c , CD 18 , CD49b , and CD49f failed to demonstrate any immunostaining with type 2 cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
All circulating T cells constitutively express the adhesion molecule leukocyte function associated antigen 1 ( LFA 1 ; CD11a / CD18 ) at either low or high surface density . ^^^ In the present paper we have compared the expression of the LFA 1 alpha chain CD11a on peripheral T cells obtained from indigenous Africans with permanent residence in Africa to T cells from indigenous Danes with permanent residence in Denmark . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Characterization of CTLL 2 Lck cells revealed markedly elevated levels of both the alpha ( CD11a ) and beta ( CD 18 ) chains of the cell adhesion molecule lymphocyte function associated 1 ( LFA 1 ) and increased binding of these T cells to a recombinant protein representing the extracellular domain of the LFA ligand , intercellular adhesion molecule 1 ( ICAM 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Furthermore , expression of adhesion molecules VLA ( CD 29 ) and LFA 1 ( CD11a ) on CD4+ and CD8+ T cells was determined . ^^^ LFA 1 ( CD11a ) was present on almost all T lymphocytes and its density did not differ between patients and controls . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
However , the mean fluorescence associated with ICAM 1 on monocytes and CD11a and CD 18 expression on lymphocytes was related to clinical stage of disease . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The leukocyte integrins consist of a common beta 2 chain ( CD 18 ) covalently linked to one of three different alpha chains ( CD11a , CD11b , CD11c ) . ^^^ Blockage of CD 18 , however , would affect all leukocytes , as would antibodies to CD11a / CD18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Peritoneal mast cells also were found to express the accessory molecules ICAM 1 ( CD 54 ) and LFA 1 beta ( CD 18 ) but not LFA 1 alpha ( CD11a ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Interestingly , we observed that in contrast to activating antibodies against CD 18 , activating antibodies against CD11a were incapable of inducing adhesion of LFA 1 to all three ligands . ^^^ LFA 1 ( CD11a / CD18 ) mediates leukocyte adhesion by binding to one of its ligands : ICAM 1 , ICAM 2 or ICAM 3 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expressions of lymphocyte function associated antigen 1 alpha ( LFA 1 alpha ; CD11a ) and VLA alpha 5 ( CD49e ) occurred in 5 of 14 and 4 of 14 specimens , respectively . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The Fc gamma RII ( CD 32 ) , the MHC class 2 antigen HLA DR and the adhesion molecules CD11a ( LFA 1 alpha ) , CD 18 and CD 54 ( ICAM 1 ) showed an unimodal distribution . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Several in vivo studies indicate that not only monoclonal antibodies ( mAbs ) directed against the common beta subunit ( CD 18 ) but also to the individual alpha subunits ( CD11a , CD11b ) can effectively inhibit different types of inflammation . ^^^ In this study we report that in the adjuvant arthritis ( AA ) alpha CD11a , alpha CD11b , or even alpha CD 18 treatment could not prevent disease development . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast to controls , the retrobulbar adipose tissue showed an increase of HLA DR expression , an activation of intercellular adhesion molecule 1 ( ICAM 1 , CD 54 ) , as well as a marked infiltration of activated T cells ( especially CD 4 ) and macrophages ( CD 68 ) , whereas a positive staining for interleukin 2 receptors ( CD 25 ) , T cells ( CD 2 ) , B cells ( CD19 / 22 ) , complement factors ( C3b ) , and LFA 1 ( CD11a ) was present only in a few patients ' specimens . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We investigated the expression of the lymphocyte function associated ( LFA ) 1 adhesion molecule , recognized by the CD11a and CD 18 monoclonal antibodies , in 53 patients with B cell chronic lymphocytic leukemia ( B CLL ) and in 37 controls . ^^^ The mean percentage of control lymphocytes expressing CD11a and CD 18 positivity was 92 + / 5 . 5 and 90 + / 8 . 7 , respectively and , in patients with B CLL , 14 . 2 + / 10 . 3 and 14 . 8 + / 10 . 3 respectively ( p < 0 . 001 ) . ^^^ No statistical difference was found between CD11a and CD 18 expression and the Rai clinical stages . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The role of CD11a , CD 18 and CD49d adhesion molecules . ^^^ The PMA and rIL 2 induced lymphocyte binding to IL 1 induced EC was inhibited by anti CD11a , CD 18 and CD49d mAbs ; on the other hand , the enhanced binding of PHA stimulated lymphocytes to EC could not be blocked by these mAbs . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We tested the promoter sequences from the leukocyte integrin CD11a ( LFA 1 ) , CD11b ( Mac 1 ) , and CD 18 subunits in retroviral vectors to express a reporter gene , adenosine deaminase , in the human leukocyte cell lines K 562 and HL 60 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The binding frequencies ( % positive ) for anti CD 2 , CD 3 , CD 5 , CD 6 , CD 7 , CD 8 , CD11a , CD 14 , CD 18 , CD 19 , CD 45 , T cell receptor , and HLA DR were not significantly affected . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
There was a quantitative increase in mean fluorescence intensity of expression of CD11a and CD 18 in DH 39 . ^^^ Northern blotting showed increased CD11a and CD 18 mRNA in DH 39 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The combination of these MoAbs ( anti CD 29 , CD 18 , CD11a , CD49d , VLA 5 , CD 44 , CD 54 , ICAM 2 , ICAM 3 MoAbs ) decreased but did not completely abrogate binding of IM 9 to BMSCs . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
SEB induced proliferation of T cells was inhibited by monoclonal antibodies to CD 2 , CD11a , CD 18 , CD 28 , CD 44 , CD 58 and ICAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Now , data which reveal that exposure of HL 60 cells to this factor also brings about an increase in the mean level of surface expression of CD11c , the alpha chain of another leukocyte integrin ( p 150 , 95 ) , but leaves CD11a , the alpha chain of the third leukointegrin ( LFA 1 ) , virtually unchanged ( < 10 % ) are presented . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Surface expression of the beta 2 integrin chains ( CD 18 , CD11a , CD11b , CD11c ) , as well as that of members of the immunoglobulin superfamily ( CD 2 , CD 54 , CD 56 , CD 58 ) , were analysed by one or two colour flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
PIF has no significant inhibitory effect on staining of CR 1 ( CD 35 ) , CR 2 , ( CD 21 ) , 20 kDa homologous restriction factor ( CD 59 ) , decay accelerating factor ( CD 55 ) , LFA 1 ( CD11a ) , or p150 . 95 ( CD11c ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In 68 patients with different leukemias the expression of the following adhesion molecules was examined : CD11a , CD 18 , CD 54 , CD 44 , CD 58 , and CD 59 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We then used flow cytometry to measure expression of the four membrane complement regulatory molecules , decay accelerating factor ( DAF ; CD 55 ) , complement receptor 1 ( CR 1 ; CD 35 ) , membrane cofactor protein ( MCP ; CD 46 ) and CD 59 ; two adhesion molecules of the integrin family LFA 1 ( alpha chain , CD11a ) , complement receptor 3 ( CR 3 ; alpha chain , CD11b ) , and their common beta chain ( CD 18 ) ; the major receptor for immune complexes Fc gamma RIII ( CD 16 ) , and the leucocyte common antigen tyrosine phosphatase ( L CA ; CD 45 ) . ^^^ PMN from RA expressed significantly less of all the complement C 3 convertase regulators ( CD 55 , CD 46 , CD 35 ) , all the adhesion molecules ( CD11a , CD11b , CD 18 ) and the phosphatase CD 45 than did blood PMN from age and sex matched control individuals . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Immunoperoxidase studies using monoclonal antibodies disclosed that interstitial foam cells were positive for antibodies of the monocyte / macrophage lineage and also expressed adhesion molecules ( CD11a , b , c , LFA 1 ) and MHC class 2 antigens . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The effects of the cytokine tumour necrosis factor alpha and the calcium ionophore A 23187 upon CD11a , CD11b , CD11c and CD 18 leucocyte membrane expression was analysed in whole blood using monoclonal antibodies and flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Immunophenotypic study revealed that leukemic cells in her peripheral blood were positive for ICAM 1 ( CD 54 ) but negative for LFA 1 alpha ( CD11a ) and LFA 1 beta ( CD 18 ) , whereas infiltrating leukemic cells in the subcutaneous plasmacytoma of the left thigh were positive for LFA 1 alpha and LFA 1 beta but negative for ICAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Effect of inhibitors of distinct signalling pathways on neutrophil Q 2 generation in response to tumor necrosis factor alpha , and antibodies against CD 18 and CD11a : evidence for a common and unique pattern of sensitivity to wortmannin and protein tyrosine kinase inhibitors . ^^^ In these studies we show that stimulation of O 2 generation by Tumor necrosis factor alpha ( TNF ) , or antibodies against the common beta 2 chain of leukocyte integrins ( CD 18 ) , or LFA 1 ( CD11a ) displays a common and unique pattern of sensitivity or insensitivity to inhibitors of different signalling pathways . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The involvement of LFA 1 and ICAM 1 in CD 45 mediated adhesion was supported by the observation that CD11a ( LFA 1 alpha ) mAb R7 . 1 , CD 18 ( LFA 1 beta ) mAb R3 . 3 , and CD 54 ( ICAM 1 ) mAb R6 . 1 or RR / l all strongly inhibited CD 45 and PMA induced aggregation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
After staining with specific fluorescent monoclonal antibodies , flow cytometric analysis was performed to evaluate the expression of CD11b ( = Mac 1 , CR 3 , or C3bi receptor ) , CD11a ( = leukocyte function antigen 1 or LFA 1 , or gp 180 / 95 ) , CD 54 ( = intercellular adhesion molecule 1 or ICAM 1 ) , and CD 45 ( = leukocyte common antigen ) on circulating leukocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of the Leu CAM proteins ( CD11a , CD11b , CD11c , CD 18 ) was also evaluated during the culture period . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The results from studying the expression of CD11a and CD 18 , the two subunits of LFA 1 , and CD 54 during stimulated DNA synthesis and differentiation suggest that IL 4 induced , or enhanced , aggregation was mainly mediated by a selective up regulation of CD 54 . ^^^ It was further demonstrated by antibody blockade to either CD11a , CD 18 or CD 54 that aggregation could be inhibited without affecting induced DNA synthesis or differentiation . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Description of the leukocyte function associated antigen 1 ( LFA 1 or CD11a ) promoter . ^^^ The CD11a / CD18 ( leukocyte function associated antigen 1 or LFA 1 ) leukocyte integrin is expressed at high levels on the cell surface of T lymphocytes and macrophages , where it mediates homotypic and heterotypic adherence between leukocytes and other cell types by binding to intracellular adhesion molecules 1 and 2 on the conjugate cell . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This enhancement was inhibited by a combination of CD11a , CD 18 , and ICAM 1 specific mAbs implicating a role of CD11a / CD18 in leukocyte adhesion to endothelium and diapedesis as part of the inflammatory process . ^^^ CD11a / CD18 ( LFA 1 ) integrin engagement enhances biosynthesis of early cytokines by activated T cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of LeuCAM on freshly isolated cells was studied using the peroxidase antiperoxidase method with monoclonal antibodies ( MoAb ) detecting CD11a , CD11b , CD11c , and CD 18 . ^^^ Compared with nonsmokers , the samples from SA and IPF patients contained an increased number of AM expressing CD11a , CD11b , CD11c , and CD 18 ( all p < 0 . 008 ) , which was correlated to the number of AM / ml BAL ( p < 0 . 008 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We therefore determined neutrophil integrin expression under various experimental conditions using a Fluorescence Activated Cell Sorter ( FACS ) after the cells had been labelled with fluorescent conjugated antibodies to the integrin subunits CD11a , CD11b and CD 18 . ^^^ Levels of labelled CD11b and CD 18 increased after activation with the chemotactic peptide formyl methionyl leucyl phenylalanine ( fMLP ) in a dose and time dependent manner , but CD11a did not , indicating that CD11a would not be a useful marker of neutrophil activation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Resting microglia constitutively expressed the LFA 1 alpha and beta chain ( CD11a and CD 18 ) in the white matter , rather than in the intact , control facial nucleus . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies against CD11a and CD 18 inhibited the binding of lymphocytes to untreated and TNF treated HUVEC and EA . hy 926 cells and ICAM 1 expression was increased on both monolayers following treatment with TNF . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Diffuse CD11a ( LFA 1 ) expression on lymphocytes was consistent throughout gestation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Furthermore , pretreatment with individual monoclonal antibodies against cell adhesion molecules ( CD11a , CD11bc , CD 18 , and intercellular adhesion molecule 1 ) reduced not only the infiltration of leukocytes but also the area of infarction in the reperfused hearts . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Analysis of blood neutrophils obtained 4 hours after reperfusion has indicated up regulation of CD11b and CD 18 but not CD11a . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Both the aggregate formation and the proliferative effects of LZ 8 were blocked by addition of monoclonal antibody to either CD 18 or CD11a , the counterreceptor complex components for ICAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The aspirin induced increase in PMN adherence to HUVEC was significantly reduced by monoclonal antibodies against CD 18 , CD11b , CD11a , and intercellular adhesion molecule 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Sodium dodecyl sulfate polyacrylamide gel electrophoresis of immunoprecipitates obtained from lysates of 125I labeled macrophages with rabbit polyclonal antibodies against the CD11a c / CD18 complex or against CD 18 , revealed four radioactive bands corresponding to CD11a , CD11b , CD11c , and CD 18 . ^^^ Monoclonal antibodies against CD11b and CD 18 inhibited by 80 and 90 % , respectively , the oxidative burst activation of the macrophages by type 1 fimbriated Escherichia coli , whereas monoclonal antibodies against CD11a , CD11c , and CD 43 were without effect . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Human lymphocyte function associated antigen 1 ( LFA 1 , CD11a / CD18 , alpha L / beta 2 ) is a cell surface heterodimer , which , together with Mac 1 ( CD11b / CD18 , alpha M / beta 2 ) and p 150 , 95 ( CD11c / CD18 , alpha X / beta 2 ) , constitutes the leukocyte integrin beta 2 ( CD 18 ) subfamily . ^^^ Characterization of the CD11a ( alpha L , LFA 1 alpha ) integrin gene promoter . ^^^ To elucidate the molecular basis for the leukocyte restricted expression of LFA 1 , the promoter region of the CD11a gene has been isolated and functionally characterized . ^^^ Transient expression of CD11a promoter based reporter gene constructs in both LFA1+ and LFA 1 cell lines demonstrated that the fragment spanning from 880 to +83 is involved in the tissue specific expression of LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies ( mAbs ) to the beta 2 chain ( CD 18 ) and to the alpha chain of LFA 1 ( CD11a ) reduced the number of IFN alpha producing cells ( IPCs ) by 30 50 % , but mAbs to CD11b or c caused no inhibition . ^^^ The results suggest that LFA 1 ( CD11a / CD18 ) participates in the early phase of the IFN alpha response and may be activated by cytokines such as IL 3 and GM CSF . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Anti CD11a ( LFA 1 ) and anti CD 54 ( ICAM 1 ) monoclonal antibodies prevented both platelet localization and hemorrhagic necrosis , and these determinants were detected on mouse platelets by immunofluorescence . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Adhesion of peripheral blood mononuclear cells to lung tumour cell lines could be inhibited by monoclonal antibodies ( MAb ) ( CD11a ; CD 18 ) against the receptor of ICAM 1 , the leukocyte function associated antigen 1 ( LFA 1 ) , but not by a MAb ( CD 54 ) against ICAM 1 itself . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Mononuclear leukocytes exhibiting strong surface LFA 1 ( CD11a and CD 18 ) expression were seen adherent to the endothelium of interstitial capillaries , with ICAM 1 and LFA 1 antigens present at sites of contact . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
When the specimen was treated with purified anti human monoclonal antibody CDw49d anti ( VLA 4 ) , purified anti human monoclonal antibody CDw49e anti ( VLA 5 ) , most of the cells in the cartilage pannus junction stained , but there were few staining cells against purified anti human monoclonal antibody CD11a anti ( LFA 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Role of polymorphonuclear neutrophil leukocytes and their integrin CD11a ( LFA 1 ) in the pathogenesis of severe murine malaria . ^^^ This syndrome may be due to an increase of production of tumor necrosis factor alpha which upregulates the endothelial expression of ICAM 1 and thus leads to adhesion of CD11a / CD18 ( LFA 1 ) bearing cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Cell surface marker analysis revealed that the cells were CD 4 , CD11a , CD11c , CD 13 , CD 14 , CD 18 , CD 33 , and HLA DR positive . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
During DHR , blood lymphocyte expression of L selectin , VLA 4 ( CD49d ; alpha chain ) , and lymphocyte function associated antigen 1 ( both CD11a ( alpha chain ) and CD 18 ( beta chain ) ) did not change . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Fetal human cardiac myocytes ( FHCM ) and a cell line derived from FHCM , termed W 1 , constitutively express low levels of MHC class 1 antigens and significant levels of ICAM 1 ( CD 54 ) , and LFA 3 ( CD 58 ) but do not express LFA 1 alpha ( CD11a ) , LFA 1 beta ( CD 18 ) , GMP 140 ( CD 62 ) , BB 1 B7 , VCAM 1 , and ELAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This reversal of the IFN alpha mediated suppression of B cell function was not blocked by any of the mAb to CD11a , CD 18 , CD 54 , or monomorphic determinants of HLA DR . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
It is LFA 1 dependent because CD11a and CD 18 mAbs inhibit homotypic aggregation , whereas CD11b and CD11c mAbs do not . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
With regard to the integrin family , monocytes expressed beta 1 ( CD 29 ) , alpha 4 , alpha 5 , alpha 6 , beta 2 ( CD 18 ) , CD11a , CD11b , and CD11c subunits , but not alpha 5 ( CD 51 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We investigated 49 acquired immunodeficiency syndrome related lymphomas ( ARLs ) for Epstein Barr virus ( EBV ) by Southern blotting and in situ hybridization and , in positive cases , used cryostat immunohistology to compare EBV latent gene expression ( EBV encoded small RNA 1 [ EBER 1 ] , EBV nuclear antigen 2 [ EBNA 2 ] , latent membrane protein 1 [ LMP 1 ] and host cell immunophenotype ( CD11a , CD 18 , CD 54 , CD 58 , CD 21 , CD 23 , CD 30 , CD 39 , CDw 70 , immunoglobulin ) patterns with those reported in other EBV infections . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Except for CD11b , all other leukocyte integrins examined ( CD11a , CD11c and CD 18 ) and their ligand ( CD 54 ) were highly expressed in non CLL cases . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Cross linking of a number of non GPI linked antigens ( CD11a , CD 18 , CD 31 , CD 35 , CD 43 , and CD 45 ) neither induced calcium fluxes , nor activated the oxidative burst . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of LeuCAM on freshly isolated cells was studied using a sensitive peroxidase antiperoxidase method with monoclonal antibodies ( mAB ) against CD11a , CD11b , CD11c , and CD 18 . ^^^ Compared with nonsmoker AM , significantly more AM from smokers expressed CD11b ( p < 0 . 001 ) , CD11c ( p < 0 . 001 ) , CD 18 ( p < 0 . 001 ) , and CD11a ( p < 0 . 004 ) , whereas there was no difference in the expression of other common epitopes of human macrophages such as CD 68 , CD 71 , CD 45 , HLA DQ , and HLA DR . ^^^ The number of AM expressing CD11a , CD11c , and CD 18 showed a correlation to the total number of AM obtained by BAL ( p < 0 . 001 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Cells exposed to phorbol myristate acetate ( PMA ) had increased expression of CD11a , CD11b , CD 18 , CD45RO , and HLA DR , whereas expression of CD 15 and CD 30 was markedly decreased . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In this reaction , CD 69 , CD 2 , and the beta 2 integrins ( CD11a , b , c , and CD 18 ) and also other molecules such as a 25 to 35 kD glycoprotein play an important part . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The regulation of expression of CD11a ( LFA 1 ) , CD 44 , CD45RA and CD45RO and of the class 2 molecules DR and DP in response to PMA , was similar in both cell lines . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The mAbs 72 87 , F 10 150 , MD2B7 and MUC76A were found to be homologous to CD11a whereas BAQ30A seemed to be homologous to CD 18 , instead of proposed initial specificity to CD11a . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of adhesion molecules , CD11a , CD11b and CD 18 , and of the function associated molecules CD 3 , CD 4 , CD 8 , CD 16 , CD 19 , CD 56 and CD 57 was assayed on peripheral blood leukocytes from normal control subjects ( n = 10 ) , and from patients with adult periodontitis PD ( n = 9 ) , ankylosing spondylitis AS ( n = 11 ) and rheumatoid arthritis RA ( n = 14 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
These responses were specific for CD 53 , as cross linking of CD11a , CD 18 , CD 35 , CD 43 , CD 44 , CD 45 , or CDw 50 did not induce leukocyte activation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In this study we report the expression of adhesion molecules ( CD11a , CD11c , CD 18 and ICAM 1 ) , lymphocyte surface markers ( CD 3 , CD 4 , CD 8 and CD 22 ) and HLA DR molecules in 25 epiretinal membranes obtained from eyes undergoing vitrectomy for the treatment of retinal detachment complicated by epiretinal membrane formation . ^^^ The results showed that cells expressing the adhesion molecules CD11a , CD11c and CD 18 were present in 5 of 25 , 17 of 25 and 11 of 23 membranes , respectively . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Cellular aggregation was inhibited by anti CD 18 mAb , anti ICAM 1 mAb , and other anti CD11a mAb . ^^^ Moreover , incubation with the HP1N mAb triggered a Ca2+ influx into the cytosol ; this effect was clearly observed upon cross linking of cell bound HP1N and was also substantiated with other anti LFA 1 ( CD11a and CD 18 ) mAb . ^^^ To this end , we have employed a monoclonal antibody ( HP1N ) raised against recombinant interleukin 2 ( rIL 2 ) activated NK cells , which recognizes the alpha chain of the LFA 1 heterodimer ( CD11a ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Farage cells do not express surface immunoglobulins ( sIg ) but display a high level of CD 19 , CD 21 , CD 22 , CD 23 , CD 39 , CD 40 B cell antigens , and various adhesion proteins , such as CD11a ( LFA 1 ) , CD 29 ( VLA 4 ) , CD 44 , CD 54 ( ICAM 1 ) , and CD 58 ( LFA 3 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Antibodies to CD11a , CD 18 , VLA 4 alpha , and VLA 5 alpha failed to inhibit binding of AML cells to bone marrow fibroblasts but anti VLA 5 alpha antibodies inhibited AML cell binding to fibronectin by approximately 50 % . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
However , a decrease in CD 23 , CD11a ( lymphocyte function associated antigen LFA 1 ) , and CD 58 ( LFA 3 ) expression and an increase in CD 38 ( a plasma cell associated antigen ) , CD 54 ( intracellular adhesion molecule ICAM 1 ) , and HLA class 1 in the tumor cells relative to the LCLs was observed . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Consistent with this interpretation , CD 28 8+ T cells were morphologically large , granular lymphocytes and expressed CD 54 ( intercellular adhesion molecule 1 ) , CD 58 ( lymphocyte function associated Ag 3 ( LFA ) ) , and high levels of CD11a ( LFA 1 ) , but did not express Ag associated with acute activation ( e . g . , HLA DR , CD 25 , CD 69 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
While surface density of CD 56 and CD 16 antigens was lower , that of beta 2 integrins ( CD 18 , CD11a , CD11b ) was higher on A NK than on NA NK cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The formation of clusters could be prevented by addition of MoAbs against CD11a ( LFA 1 alpha ) or CD49d ( VLA 4 alpha ) , resulting in an apoptotic appearance of virtually all B lymphocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A non lymphocyte depleting monoclonal antibody to the adhesion molecule LFA 1 ( CD11a ) prevents sensitization to alloantigens and effectively prolongs the survival of heart allografts . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Peak plasma concentrations to be expected under these experimental conditions are less than 1 micrograms / ml . ( d ) The surface receptors found to be affected include among others : CD 2 ( LFA 2 ) and CD11a ( LFA 1 alpha ) and CD 18 ( LFA 1 beta ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To inhibit leukocyte sequestration directly , mice were treated with anti CD11a ( LFA 1 ) or anti CD11b ( Mac 1 ) before endotoxin challenge . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Rosetting of armed U 937 cells could be inhibited with MoAbs versus the alpha chains of CD11a ( LFA 1 ) , 11b ( Mac 1 ) , or 11c ( p 150 , 95 ) by 67 % , 70 % , and 61 % , respectively ( P < . 007 ) , whereas binding of ICs to U 937 cells was unaffected . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Anti CD 2 and CD11a ( LFA 1 ) mAbs partially blocked IL 1 beta production by 25 % and 35 % , respectively . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Preincubation of the IL 3 treated cultures with anti IL 3 , anti leukocyte function associated antigen 1 ( LFA 1 ) alpha chain ( CD11a ) , and anti intercellular adhesion molecule 1 ( ICAM 1 ) inhibited cell fusion . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies against the selectins , CD 18 , CD11a , CD11b , and ICAM 1 have all been shown to significantly reduce the influx of neutrophils into sites of inflammation in various animal models . . ^^^ Once the marginated neutrophil forms a stationary adhesion with endothelial cells , it is stimulated by chemotactic factors to downregulate the selectin based adhesion and upregulate adherence dependent on beta 2 integrins , principally CD11a / CD18 ( LFA 1 ) and CD11b / CD18 ( Mac 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To determine the role of various adhesion molecules during the processes of lymphocyte binding and transmonolayer migration ( diapedesis ) , lymphocytes were treated with monoclonal antibody ( mAb ) specific for CD11a ( alpha L subunit of leucocyte functional antigen 1 ; LFA 1 ) , CD 18 ( beta 2 subunit of leucam family ) and CD49d ( alpha 4 subunit of very late activation antigen 4 ; VLA 4 ) and EC with mAb specific for CD 54 ( intercellular adhesion molecule 1 ; ICAM 1 ) and CD 106 ( vascular cell adhesion molecule 1 ; VCAM 1 ) . ^^^ Binding of the highly adhesive but non migratory Con A activated lymphocytes was inhibited by mAb to CD11a ( reduced to 73 % and 65 % of control lymphocyte adhesion ) and CD 18 ( 42 % and 54 % ) on non activated and IL 1 beta treated EC , respectively , but not by mAb to ICAM 1 or VCAM 1 . ^^^ Diapedesis of the highly migratory T cell line lymphocytes was also blocked by antibodies to CD11a ( reduced to 11 % and 10 % of control T cell migration ) , CD 18 ( 29 % and 43 % ) but in addition was also inhibited by anti ICAM 1 ( 17 % and 53 % ) on non activated and IL 1 beta treated EC , respectively . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Flow cytometric comparisons of labeled and unlabeled cells demonstrated that fluorescence labeling of neutrophils and eosinophils with CFDA did not alter basal surface expression of the beta 2 integrins ( i . e . , CD11a CD11b or , CD 18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Phorbol ester ( TPA ) induced increase in cell surface expression of adhesion structures , i . e . intercellular adhesion molecule 1 ( ICAM 1 , CD 54 ) , beta 2 integrin LFA 1 ( CD11a ) , complement regulatory cell membrane protein protein ( CD 59 ) and leukocyte common antigen ( CD 45 ) in human erythroid / myeloid leukemia cell line K 562 was inhibited by staurosporine , an inhibitor with broad , non selective protein kinase inhibitory profile , but not by CGP 41 , 251 , a benzoylated staurosporine derivative with the selective protein kinase C ( PKC ) inhibitory activity . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD11a , CD11b , CD 18 , and CD 35 was studied by flow cytometry on neutrophils and monocytes . ^^^ Adherence of human monocytes to haemodialysis membranes : LFA 1 ( CD11a / CD18 ) CR 1 ( CD 35 ) and CR 3 ( CD11b / CD18 ) triggering promotes the biosynthesis of platelet activating factor and adherence . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Apart from a slight increase in the expression of integrin alpha 4 beta 1 ( very late activation antigen 4 , VLA 4 ) , no changes in the expression of other adhesion molecules , such as sialyl Lewis 10 , CD 44 , and leukocyte function associated antigen 1 ( LFA 1 ) , which is known to be a heterodimer of CD11a and CD 18 , were observed after treatment with IFN alpha . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The aim of this study was to analyze the expression of CD11a and CD 18 within the CD8+CD45RA+ population in young HIV infected individuals at different stages of disease as a marker of activation and of disease progression . ^^^ Blood cells from 82 HIV infected individuals and 23 age matched healthy controls were stained with unconjugated CD11a , CD 18 , PE goat F ( ab ' ) 2 anti mouse , FITC CD45RA , and TRI Color CD 8 . ^^^ The relative increase of CD11a and CD 18 expression in CD8+CD45RA+ T lymphocytes parallels the decrease of CD4+ cells and the progression of disease : an inverse correlation between the percentages of CD4+ cells / microliter and CD8+CD45RA+CD11abright cells ( p < 0 . 001 ) and a direct correlation between the number of CD4+ lymphocytes per microliter and both the number of CD8+CD45RA+CD11adim cells ( p < 0 . 001 ) and the number of CD8+CD45RA+CD11abright ( p = 0 . 002 ) was observed . ^^^ CD8+CD45RA+ T lymphocytes present two distinct subpopulations expressing the CD11a molecule ( LFA 1 alpha chain ) with different intensity . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Peripheral blood neutrophils showed decreased expression of CD11b ( p = 0 . 1 ) , CD 18 ( p = 0 . 07 ) , and L selectin ( p = 0 . 09 ) , which approached statistical significance without any associated effects on CD11a , CD15s , or CD 44 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Identification of Sp 1 binding sites in the CD11c ( p 150 , 95 alpha ) and CD11a ( LFA 1 alpha ) integrin subunit promoters and their involvement in the tissue specific expression of CD11c . ^^^ The leukocyte integrins LFA 1 ( CD11a / CD18 ) and p 150 , 95 ( CD11c / CD18 ) mediate cell cell and cell extracellular matrix interactions during inflammatory responses and signal transduction into the cytoplasm . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Reduced expression of membrane proteins was not confined to those anchored through GPI several transmembrane molecules including CD11a CD11b and CD 18 were also reduced on apoptotic PMN , whilst other were little changed ( CD 35 , CD 46 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This study was designed to determine whether acute exercise alters the activity of CD11a ( LFA 1 ) on NK cells . ^^^ Splenic natural killer cell activity ( NKCA ) was determined using a standard 51Cr release assay , using fresh splenocytes or splenocytes which had been incubated for 3 days with 100 U rIL 2 . 10 micrograms / ml of mAb to LFA 1 ( anti CD11a ) or an equal volume of culture medium were added to the effector : target suspensions prior to 4 . 5 h incubation . ^^^ These results suggest that acute exercise renders mouse splenocytes more resistant to the blockade effect of anti CD11a ( LFA 1 ) and , as result , may alter killing of tumour target cells in vitro . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of molecules of the beta 2 integrin family ( CD11a , CD11b , CD11c , and CD 18 ) was explored on 2 human megakaryocytic cell lines and on platelets from different donors by immunofluorescence and flow cytometry using a large panel of mAb . ^^^ CD11a , CD11b , CD11c and CD 18 were detected on the megakaryocytic cell lines DAMI and HEL . ^^^ A low and variable expression of CD11a , CD11b and CD 18 determinants was also detected on resting platelets ; this expression was markedly increased when platelets were activated by thrombin . ^^^ Expression of CD 18 was closely correlated to that of CD11a or CD11b when comparing the fluorescence intensity observed in different experiments . ^^^ This binding was increased when platelets were activated by thrombin and was decreased by an anti CD11a , CD 18 and anti CD 54 mAb . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This was confirmed using COS 7 and WOP cells doubly transfected with alpha M ( CD11b ) and beta 2 ( CD 18 ) or with alpha L ( CD11a ) and beta 2 when it was found that the Ab bound only the alpha M beta 2 transfectants . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Analysis of expression of other adhesion molecules demonstrated that CD11a , CD 18 , CD 44 , CD 45 , CD 48 , CD 54 , and CD62L were significantly increased by either anti CD 2 or anti CD 3 mAbs while the combination was not synergistic . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Whereas CD11a was increased only on monocytes , CD11b , CD11c , and CD 18 were strongly enhanced on monocytes and polymorphonuclear cells ( PMNs ) after treatment with MDPs . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Several studies indicate that the 1 domain located in the alpha chain ( CD11a ) of leukocyte function associated antigen 1 ( LFA 1 ; CD11a / CD18 ) plays an essential role in ligand recognition . ^^^ We recently identified three distinct epitopes ( IdeA , IdeB , and IdeC ) within the CD11a 1 domain , recognized by antibodies that block binding of LFA 1 to intercellular adhesion molecules ( ICAM ) 1 , 2 , and 3 . ^^^ In the present study , we used a series of human / murine CD11a 1 domain chimeras , to localize a fourth 1 domain epitope ( IdeD ) , recognized by three independently derived anti CD11a antibodies that selectively block the binding of LFA 1 to ICAM 3 , but not to ICAM 1 . ^^^ Although mutation of Asp 182 and Ser 184 failed to abolish ICAM 3 adhesion of LFA 1 transfectants , alignment of these residues with the crystal structure of the CD11a 1 domain suggested that the IdeD epitope is located in close proximity to residues ( Ile 126 and Asn 129 ) recently implicated in the ICAM 3 binding site . ^^^ Taken together , these data indicate that distinct regions of the CD11a 1 domain contain epitopes for antibodies that either selectively inhibit binding of LFA 1 to ICAM 3 , or interfere with both ICAM 1 and ICAM 3 binding of LFA 1 . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Most TDC were LFA 1 ( CD11a ) + , CD18+ , ICAM 1 ( CD 54 ) + and CD 53 ( OX 44 ) + , but only certain subsets expressed CD11b and thymocyte markers Thy 1 , CD 2 , CD 4 and CD 8 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We examined the expression of adhesion molecules of the integrin family ( CDw49b , CDw49d , CDw49e , CDw49f , CD 18 , CD11a CD11c , and CD11b ) , the immunoglobulin superfamily ( CD 54 , CD 56 , CD 58 , and CD 31 ) , the selectin family ( ELAM 1 , LECAM 1 , and CD 62 ) , and CD 44 , CD41b , and CD42b on platelets , megakaryocytes , and megakaryocytes with CP . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In a retrospective study based on 107 B CLL patients , the expression of the adhesion molecules CD 44 , CD11a , CD11b , CD11c , CD 18 , CD 25 and CD 54 was analysed in bone marrow cryostat sections by immunohistochemistry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
At the low cation concentration , stopping was largely inhibited by antibodies to the neutrophil integrins CD 18 or CD11b , but not CD11a . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Receptor ligation with either immobilized MoAb to CD 18 or Fas induced membrane disruption and DNA degradation in LAK cells independently of K 562 , and MoAb to CD 18 , CD11a , or CD11b enhanced DNA fragmentation induced by anti Fas . ^^^ In conclusion , ( 1 ) K 562 induced death of LAK cells involves primarily CD 18 , although other molecules , such as Fas , may also be involved ; ( 2 ) K 562 mediated apoptosis of LAK cells requires tyrosine phosphorylation and protease activity ; ( 3 ) engagement of Fas by immobilized MoAb or Fas L on target cells can also kill LAK cells ; and ( 4 ) Fas immobilized MoAb synergizes with coimmobilized MoAb to CD11a , CD11b , or CD 18 for LAK cell killing . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition , it is unlikely that the O 2 ( ) induced chemotactic response is due to soluble HIV 1 proteins from infected cells or to amplified expression levels of cell surface functional molecules such as CD 4 and LFA 1 ( CD11a and CD 18 ) as well as HIV 1 Env gp 120 on uninfected and / or infected cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Engagement of adhesion molecules ( CD 18 , CD11a , CD 45 , CD 44 , and CD 58 ) enhances human immunodeficiency virus type 1 replication in monocytic cells through a tumor necrosis factor modulated pathway . ^^^ Cross linking of CD 18 , CD11a , or CD 45 by immobilized antibodies produced up to an 11 fold enhancement of HIV 1 release in the OM10 . 1 monocytic cell line in a tumor necrosis factor alpha ( TNF alpha ) dependent manner . ^^^ After phenotypic differentiation of OM10 . 1 cells , engagement of cell membrane proteins CD 18 , CD11a , CD 44 , CD 45 , or CD 58 by soluble antibodies enhanced HIV 1 replication in a TNF alpha dependent manner . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
When the reactivity of mNI 11 and mAbs binding human differentiation antigens such as CD11a , CD11b , CD11c , CD 14 , CD 16 , CD 18 , CD 23 , CD 28 , CD 29 , CD 31 , CD 43 , CD 44 , CD45RA , CD49d , CD 50 , CD 54 , CD 58 , CD 80 , CD 102 , CD 106 , HLA class 1 , or HLA class 2 antigen was compared , no mNI 11 reactivity resembling that of these mAbs was found . mNI 11 markedly induced homotypic cell aggregation of U 937 cells when they were stimulated with LPS . ^^^ The mNI 11 induced aggregation was blocked by the addition of ethylenediaminetetraacetate , and also when incubated at 4 degrees C . mAbs to CD11a / CD18 ( lymphocyte function associated antigen 1 ; LFA 1 ) and CD 54 ( intercellular adhesion molecule 1 ; ICAM 1 ) completely blocked the LPS U 937 cell aggregation induced by mNI 11 . ^^^ The mNI 11 induced LPS U 937 cell adhesion to HUVECs was not reduced in the presence of LFA 1 ( CD11a / CD18 ) or ICAM 1 ( CD 54 ) mAbs . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The induction of IL 1 beta mRNA during anti CD 3 mitogenesis was significantly inhibited by anti CD 2 mAb , whereas mAb against CD11a , CD 18 , CD 69 , or CD 5 molecules had no effect . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The leukocyte integrin LFA 1 ( CD11a / CD18 ) plays an important role in lymphocyte recirculation and homotypic interactions . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The distribution of RCMV , intercellular adhesion molecule 1 ( ICAM 1 ) and its leucocyte receptor CD11a ( LFA 1 ) were investigated by immunohistochemistry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Infiltrating mononuclear cells expressed CD11a ( 68 % ) , CD 18 ( 73 % ) , CD11b ( 13 % ) , CD11c ( 21 % ) , CD 58 ( 13 % ) , CD 4 ( 44 % ) , CD 8 ( 17 % ) , CD62L ( L selectin ) ( 18 % ) , CD49d ( 38 % ) , CD49e ( 15 % ) , CD 2 ( 56 % ) , and CD 44 ( 77 % ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The adhesion molecule , lymphocyte function associated antigen ( LFA 1 ) consisting of two subunits , CD11a and CD 18 , mediates lymphocyte migration into tissue and cell effector functions . ^^^ The majority of CD25+ T cells were expressing CD11a and CD 18 with low density . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The ratios of CD11a , CD 18 , HLA DP on T cells and CD 54 on B cells of 54 patients with active systemic lupus erythematosus ( SLE ) were examined . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Results demonstrated increase in CD8+ cell and decrease in CD4+ cell , CD4+ / CD8+ , and CD4+ / CD45RA+ cell , as well as decrease in expression of CD11a and CD 18 on CD4+ cell surface , Expression of CD11a and CD 18 on CD8+ cell , and CD 54 on CD20+ cell increased , Moreover , increase in CD 18 on CD8+ cell correlated inversely with decrease in CD4+ CD45RA+ cell ( P < 0 . 05 ) and positively with increase in CD 54 on CD20+ cell ( P < 0 . 01 ) . ^^^ Peripheral blood lymphocyte phenotype ( CD 3 , CD 4 , CD 8 , CD 20 , CD45RA and CD45RO ) and adhesion molecule phenotype ( CD11a / LFA 1 alpha , CD18 / LFA 1 beta and CD54 / ICAM 1 ) were investigated in 35 patients with systemic lupus erythematosus ( SLE ) by using flow cytometric analysis and dual immunofluorescence staining method . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Glomerular expression of intercellular adhesion molecule 1 ( ICAM 1 ) ( CD 54 ) and membrane cofactor protein ( MCP ; CD 46 ) and positive infiltrating cells in leukocyte function associated antigen 1 ( LFA 1 ) alpha ( CD11a ) and C3bi receptors ( CR3 / CD11b , CR4 / CD11c ) were examined by the indirect immunoperoxidase method on 43 sets of repeated renal biopsy specimens from patients with immunoglobulin A nephropathy . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Adhesion of neutrophils from patients with BD to HUVEC stimulated with tumour necrosis factor ( TNF ) , interleukin 1 ( IL 1 ) , and lipopolysaccharide ( LPS ) and adhesion molecule ( CD11a , CD11b , CD 18 and L selectin ) expression on the patient ' s neutrophils and lymphocytes were determined , and the serum concentration of IL 8 was measured . ^^^ Patients ' sera induced an increase in surface expression of CD11a and CD 18 on normal neutrophils and intercellular adhesion molecule 1 ( ICAM 1 ) expression on HUVECs . ^^^ Monoclonal antibodies to CD11a , CD11b , CD 18 , and ICAM 1 caused varying degrees of inhibition of neutrophil adhesion . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The majority of PCL T cells exhibited markers of the thymus dependent lineage ( CD 2 , CD 3 , TcR alpha beta , CD 8 alpha beta or CD 4 ) and surface antigens associated with memory and activation ( CD45RO , CD11a , CD 18 , CD49d , HLA DR ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
These three compounds had no effect on the expression of CD 99 , CD 45 , CD11a , CD 18 or other [ correction of others ] known integrins expressed at the surface of the cells studied . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Human PMNs ( 2 . 5 10 10 ( 5 ) ) were saturated with specific monoclonal antibodies for the beta 2 subunits ( CD11a , CD11b , CD 18 ) or nonspecific monoclonal antibodies for 30 minutes on ice before a 1 hour incubation with sICAM 1 ( 75 ng / ml ) at 37 degrees C . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Adhesion of basophils to endothelial cells was inhibited by mAb recognizing CD 18 , CD11a , and / or CD11b , with the pattern and magnitude of inhibition dependent upon the activation state of the basophils and endothelium . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A dose searching trial of an anti LFA 1 monoclonal antibody in first kidney transplant recipients . 25 . 3 , a mouse IgG 1 monoclonal antibody ( MoAb ) , directed at the alpha chain of the LFA 1 molecule ( CD11a ) has been used in prophylaxis of rejection in recipients of cadaveric kidney graft . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In this study , we examined the preventive effect of monoclonal antibodies ( MAb ) against CD11b ( 1B6 ) , CD11a , or CD 18 ( CL 26 ) on platelet activating factor ( PAF ) induced bowel injury . ^^^ Some rats wee also injected intravenously with 1B6 ( anti CD11b ) , anti CD11a , CL 26 ( anti CD 18 ) , or combined anti CD11a and 1B6 , 30 min before PAF . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Combined blockade of CD11a and CD 18 was also more effective than either blocking intervention alone . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Cell interaction molecules lymphocyte function associated antigen 1 ( LFA 1 ) ( CD11a ) , intracellular adhesion molecule 1 ( ICAM 1 ) ( CD 54 ) , ICAM 3 ( CD 50 ) and B7 . 2 ( CD 86 ) were up regulated on HL 60 R 7 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Lymphocytes were treated with antibodies specific for CD11a ( alpha L subunit of LFA 1 ) , CD 18 ( beta 2 subnit of the leucam family ) and CD 49 d ( alpha 4 subnit of very late activation antigen 4 , VLA 4 ) , and the RPE with antibodies specific for CD 54 ( intracellular adhesion molecule 1 , ICAM 1 ) and CD 106 ( vascular cell adhesion molecule 1 , VCAM 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Despite extensive research in this field , only three members of this integrin subfamily have been described : CD11a / CD18 ( LFA 1 ) , CD11b / CD18 ( Mac 1 ) , and CD11c / CD18 ( p 150 , 95 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast , CD 18 ( beta 2 integrin ) , CD 61 ( beta 3 integrin ) , ICAM 2 , CD11a , CD11b and CD11c were all absent from these cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To reduce the high risk of graft rejection in this setting without increasing the conditioning regimen , a protocol based on the infusion of an antiadhesion antibody directed against the CD11a ( leukocyte function associated antigen 1 [ LFA 1 ] ) molecule was performed by the European Bone Marrow Transplantation European Society for Immunodeficiency group with promising results . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD11a , but not CD11b , was responsible for most of the CD 18 mediated binding . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We investigated the expression of adhesion molecules including LFA 1 alpha ( CD11a ) , Mac 1 ( CD11b ) , LFA 1 beta ( CD 18 ) , VLA beta 1 ( CD 29 ) , H CAM ( CD 44 ) , VLA 4 ( CD49d ) , VLA 5 ( CD49e ) , ICAM 1 ( CD 54 ) , N CAM ( CD 56 ) , LFA 3 ( CD 58 ) , VNR beta ( CD 61 ) , and LECAM 1 ( CD62L ) on fresh myeloma cells and human myeloma cell lines . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
These deficits , in part , are due to functional and quantitative defects in neonatal Mac 1 ( CD11b / CD18 ) , whereas LFA 1 ( CD11a / CD18 ) function is similar to that found in adults ( D . ^^^ We conclude that although neonatal animals have significantly less neutrophil CD11a , the diminished levels did not contribute to a reduced ability to emigrate to the peritoneum and , like adult animals , neonatal animals primarily utilize LFA 1 for accumulation in this model . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Surface expression of LFA 1 , Mac 1 , p 150 , 95 , and VLA 4 on neutrophils , lymphocytes , and monocytes was measured by fluorescent antibody cell sorting with monoclonal antibodies against CD11a , CD11b , CD11c , CD 18 , CD49d , and CD 29 respectively . ^^^ We tested the hypothesis that the expression of the beta 1 chain integrin VLA 4 ( CD49d / CD29 ) and the beta 2 chain integrins LFA 1 ( CD11a / CD18 ) , Mac 1 ( CD11a / CD18 ) , and gp 150 , 95 ( CD11c / CD18 ) is increased on leukocytes in patients with active WG . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Furthermore , SA 1042 does not interfere with the binding of monoclonal antibodies directed to other molecules , gp 41 , CD 4 , CD11a , CD 18 , CD 26 , CD 44 or CD 54 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Human PBL were grown on ePTFE in culture and labeled with monoclonal antibodies to CD11a , b , c , and / or CD 18 . ^^^ CD 18 was constitutively expressed and CD11a decreased over time . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
METHODS : Co stimulatory activity was measured by cross linking antibodies to CD11a or CD 18 with anti CD 3 antibodies to plastic and then measuring the proliferative response of CD4+ T cells to these antibodies . ^^^ RESULTS : A house duct mite allergen specific CD4+ T cell line ( TH 2 ) demonstrated much greater dependence on both CD11a and CD 18 than a mycobacterial antigen specific CD4+ T cell line ( TH 1 ) . ^^^ OBJECTIVE : This study was therefore performed to investigate co stimulatory properties of the LFA 1 ( CD11a / CD18 ) complex in the activation of human CD4+ T cell lines and clones of TH 0 , TH 1 and TH 2 subsets . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of other integrin , selectin , or immunoglobulin superfamily molecules ( CD11a , CD 18 , CD 44 , CD 45 , CD 48 , CD 54 and CD62L ) were all significantly increased by anti CD 2 or anti CD 3 mAbs . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We measured the levels of soluble intercellular adhesion molecule 1 ( sICAM 1 ) , CD11a , CD11b , CD 18 , endotoxin , and various inflammatory cytokines to clarify the relationship between adhesive molecules and cytokines in sepsis . ^^^ No significant difference was observed in the CD11a , CD11b , and CD 18 levels between the two groups . ^^^ The sICAM 1 levels significantly correlated with the levels of endotoxin , tumor necrosis factor alpha ( TNF alpha ) , and IL 8 , but CD11a , CD11b , and CD 18 levels did not correlate with endotoxin or cytokine levels . ^^^ These findings suggest that ICAM 1 production is induced by endotoxins and cytokines produced in excess by inflammatory reactions and that endotoxins and cytokines are involved in qualitative , but not quantitative changes in LFA 1 ( CD11a / CD18 ) and Mac 1 ( CD11b / CD18 ) . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Strategies targeting lymphocyte function associated antigen 1 ( LFA 1 , CD11a / CD18 ) and intercellular adhesion molecule 1 ( ICAM 1 ) have previously been shown to produce long term survival of solid organ allografts in animals only when both CD11a and ICAM 1 are targeted for a brief ( 6 7 days ) time or when extended ( 14 weeks ) treatment with anti CD11a monoclonal antibody ( mAb ) is administered . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Analysis of the effect of IL 5 on surface molecule expression by FACS analysis revealed increased expression of CD11b molecules and decreased expression of L selectin , but no change in the expression of CD11a , CD 18 , CD 29 , CD49d and CD 32 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To investigate the mechanism of synovial pannus formation in rheumatoid arthritis , immunohistochemical and immunoelectron microscopic studies with monoclonal antibodies against the adhesion molecules , CD 54 ( ICAM 1 ) , CD11a ( LFA 1 ) , CDw49a ( VLA 1 ) , CDw49b ( VLA 2 ) , CDw49c ( VLA 3 ) , Cdw49d ( VLA 4 ) and CDw49e ( VLA 5 ) , were carried out to determine the pattern of distribution of these molecules at the rheumatoid synovial cartilage junction . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CONCLUSIONS : These data indicate that the functional expression of CD11a ( LFA 1 ) on CD8+ T cells is suppressed in cancer involved regional lymph nodes in patients with gastrointestinal carcinoma . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Immunohistochemistry was performed for CD 18 , CD11a , CD11b , CD11c , alpha d , ICAM 1 , ICAM 2 , and ICAM 3 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of CD 18 , CD11a , CD11b and CD11c on the surface of polymorphonuclear leukocytes was examined by flow cytometry with monoclonal antibodies . ^^^ OBJECTIVES : This study evaluated the role of neutrophil adhesion molecules LFA 1 ( CD11a / CD18 ) , Mac 1 ( CD11b / CD18 ) and p 150 , 95 ( CD11c / CD18 ) in patients undergoing percutaneous transluminal coronary angioplasty ( PTCA ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Some of these TCR antagonistic analogues carrying relatively conservative amino acid substitutions partially activated the T cells to induce large increases in size and expression levels of CD 4 , CD11a ( LFA 1 ) , CD 28 , CD49d ( VLA 4 ) , and CD 95 ( Fas ) , and small increases in CD 25 and CD 44 expressions on the cell surface . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
When the reactive patterns between mNI 58A and the mAbs to various human differentiation antigens ( CD11a , CD11b , CD11c , CD 14 , CD 16 , CD 18 , CD 23 , CD 28 , CD 29 , CD 31 , CD 43 , CD 44 , CD45RA , CD 50 , CD 54 , CD 58 , CD 80 , CD 102 , CD 106 , HLA class 1 and class 2 antigen ) were compared , that of mNI 58A was found to be similar to those of the leukocyte function associated antigen 1 ( LFA 1 ) mAbs . ^^^ The U 937 cells markedly adhered to the tumor necrosis factor alpha ( TNF alpha ) stimulated human umbilical vein endothelial cells ( HUVECs ) and also to the extracellular matrix protein , fibronectin , but mNI 58A did not enhance or block these adhesion process . mNI 58A precipitated two glycoproteins with molecular weight 180 kDa and 95 kDa as determined by SDS PAGE analysis , which were identical to the LFA alpha ( CD11a ) and beta ( CD 18 ) chains of leukocyte integrin precipitated by the CD11a mAbs , respectively . ^^^ Sequential immunoprecipitation studies using the CD11a mAb ( 2F12 ) also indicate that mNI 58A recognizes an epitope on the alpha chain of the LFA 1 molecule . ^^^ The ability of mNI 58A to block the PMA U 937 cells and to induce the spread formation of these cells suggests that mNI 58A is a novel mAb reacting with an epitope on the alpha chain of LFA 1 different from those recognized with the existing CD11a mAbs . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Frozen brain sections were prepared and stained with monoclonal antibodies to complement receptor type 3 ( OX 42 ) , major histocompatibility complex ( MHC ) class 1 and class 2 antigens ( OX 18 and OX 6 , respectively ) , a pan macrophage / monocyte marker ( ED 1 ) , intercellular adhesion molecule 1 ( ICAM 1 ) , LFA 1 alpha chain ( CD11a ) and beta chain ( CD 18 ) , and T cells ( CD 5 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies ( MoAbs ) that recognize chymopapain resistant epitopes on several coexpressed cell surface markers were identified : these included MoAbs directed against CD11a , CD 13 , CD 18 , CD 38 , CD45RO , CD 51 , HLA DR , Thy 1 , c kit , flt 3 ( STK 1 ) , and mdr 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The adhesion between FDCs and B cells is mediated by ICAM 1 ( CD 54 ) LFA 1 ( CD11a ) and VCAM VLA 4 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
No significant changes in the cell surface expression of adhesion molecules CD11a , CD11b , CD11c , CD 18 , CD 54 , CD 44 , CD49d ( alpha 4 integrin ) and CD62L ( L selectin ) were observed on MV infected monocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In this study , we investigated the role of adhesion molecules , such as CD 2 , CD11a , CD 18 , and CD 54 in the recruitment of pit cells to the liver . ^^^ Immunostaining for electron microscopy , and two color flow cytometry showed that most pit cells expressed CD 2 , CD11a , CD 18 , and CD 54 . ^^^ After intravenous injections into rats with anti CD 2 , anti CD11a , and anti CD 18 antibodies , the number of pit cells per square millimeter in frozen sections of liver tissue decreased . ^^^ These results indicate that blocking of CD 2 , CD11a , CD 18 , and CD 54 antigens on blood LGL and / or liver endothelium decreased the number of pit cells in the liver . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies against CD11a and CD 18 significantly inhibited the increased conversion of XD ( xanthine dehydrogenase ) to XO induced by PMA activated neutrophils . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Whereas the roles of the common beta chain ( CD 18 ) and of the alpha subunit of MAC 1 ( CD11b ) have been studied extensively , the role of the alpha subunit of LFA 1 ( CD11a ) remains less well defined . ^^^ This phenomenon involves interactions between neutrophil beta 2 integrins ( CD11a / CD18 [ lymphocyte function associated antigen 1 , or LFA 1 ] , CD11b / CD18 [ membrane attack complex 1 , or MAC 1 ] , and CD11c / CD18 [ p 150 , 95 ] ) and their endothelial ligands . ^^^ CONCLUSIONS : These results suggest the involvement of the alpha subunit of LFA 1 ( CD11a ) in neutrophil mediated reperfusion injury incurred by transplanted hearts . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Differential leukocyte count was performed on cytospin preparations and the expression of integrin alpha ( CD11a , CD11b , CD11c ) and beta ( CD 18 ) chains was assessed on granulocytes and mononuclear cells by immunocytology . ^^^ The numbers of neutrophils expressing CD11b and CD 18 , but not CD11c or CD11a , were increased in the subjects with airway obstruction compared with those without airway obstruction . ^^^ No significant correlations were found between CD11a , CD11b , CD11c , CD 18 positive mononuclear cells and lung function measurements . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
DLGL are CD56bright and express the CD 2 , CD11a , CD 18 , CD 38 and CD 50 molecules , dimly the CD 54 molecule , and poorly the CD 102 and CD 69 molecules . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Treatment of Dex induced monocytes with antibodies against RM3 / 1 , CD11a , CD11b , CD11c , CD 14 and CD 18 resulted in suppression of adhesion to stimulated HUVEC by 46 % , 18 % , 17 % , 12 % , 25 % and 15 % , respectively . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The autologous MECLR was inhibited in samples from all patients by mAb to CD 2 ( LFA 2 ) , CD11a ( LFA 1alpha ) , CD 18 ( LFA 1beta ) , ICAM 1 , CD 58 ( LFA 3 ) and an antiserum to IL 1beta . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
When the monoclonal antibody immobilization of granulocyte antigen assay was used , three sera samples reacted with Fc gamma receptor 3 , three with the 58 to 64 kDa protein carrying the neutrophil antigen NB 1 , one with CD11a , and one with CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Lymphocyte function associated antigen 1 ( LFA 1 ; CD11a / CD18 ) is involved in leukocyte adhesion during cellular interactions essential for immunologic responses and inflammation . mAbs against LFA 1 have been shown to inhibit several T cell dependent immune functions in vitro and prevent graft failure after bone marrow transplantation in vivo . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
RESULTS : Conjunctival dendritic cells exhibited surface markers both in normal and inflammatory conditions : class 2 antigens HLA DR and HLA DQ , CD1a , vimentin , CD11a and CD 18 ( LFA 1 ) , CD 22 , CD45RO and CD 50 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies ( 2 mg / kg ) to ICAM 1 and the alpha chain ( CD11a , CD11b ) or the beta chain ( CD 18 ) of beta 2 integrins had no significant effect on hepatic neutrophil count after endotoxin . ^^^ In contrast , these antibodies inhibited peritoneal neutrophil infiltration in response to glycogen administration by 28 % ( CD11b ) , 60 % ( CD11a , ICAM 1 ) , and 92 % ( CD 18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of surface adhesion molecules on granulocytes , monocytes ( CD11a , CD11b , CD11c , CD 18 , L selectin ) , and platelets ( P selectin , gpIIb IIIa ) was determined after incubation with different graft surfaces [ expanded polytetrafluoroethylene ( ePTFE ) or woven Dacron ] . ^^^ Both graft materials demonstrated increased expression of CD11a and CD 18 adhesion molecules on white blood cells at 30 min , followed by a downregulation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We have generated mice deficient in the beta 2 integrin LFA 1 by targeted disruption of the CD11a gene in embryonic stem cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We found that the combination of anti ICAM 1 ( 1 mg / kg ) added to the donor lung flush , and anti CD11a , anti CD 18 , and anti ICAM 1 ( 2 mg / kg i . v . of each ) given to the recipient prior to reperfusion , resulted in significantly improved lung graft pAO 2 by ABG , and decreased alveolar protein , cell count , and myeloperoxidase activity compared with control animals . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We investigated the roles of CD11a , CD11b , CD 18 , and CD 54 adhesion molecules in non adherent peripheral blood mononuclear cells ( NPBMC ) induced DNA fragmentation of cytomegalovirus ( CMV ) infected cells . ^^^ Treatment of NPBMC with monoclonal antibodies to CD11a , CD11b , CD 18 , and CD 54 significantly reduced cytotoxicity against CMV infected cells . ^^^ A combination of anti CD11a , anti CD11b , and anti CD 18 antibodies further inhibited cytotoxicity against CMV infected cells . ^^^ These results indicate that LFA 1 ( CD11a / CD18 ) , Mac 1 ( CD11b / CD18 ) , and ICAM 1 ( CD 54 ) adhesion molecules are involved in natural killer ( NK ) cell induced DNA fragmentation in CMV infected cells . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
No changes in HLA DR or in other adhesion protein ( CD11a , CD11c , CD 18 , CD 54 ) expression were detected , and levels were similar in both patients and normal controls . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Finally , crosslinking of CD11a or CD11b , but not of CD 18 , with mAbs and F ( ab ' ) 2 fragments produced a delay in spontaneous apoptosis , whereas crosslinking of L selectin with mAb or its natural ligand , sulfatides , accelerated the apoptotic process . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Moreover , CD11a and CD 18 were among two adhesion molecules which showed a sharp increase in expression , whereas no changes on expression of CD11b , CD 44 and CD 54 were detected . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Comparable expression of CD 18 , CD11a , CD11b , and CD11c could be detected by immunofluorescence in leukocytes from samples drawn from either arm before tourniquet application . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD 50 ( ICAM 3 ) has been identified as the third CD11a / CD18 ( LFA 1 ) counter receptor . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD 18 , the beta chain of the beta 2 integrin family of adhesion molecules , is associated with three different alpha chains ( CD11a , b , and c ) and is expressed on the surface of all types of leukocytes . ^^^ Pretreatment of PMN with anti CD 18 , but not an isotype matched control monoclonal antibody ( MAb ) or anti CD11a MAb , blocked the binding of 14C labeled CneF to PMN . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
While transcripts for both CD11a ( alpha subunit ) and CD 18 ( beta subunit ) were readily detected in LCLs , BL lines contained the transcript for the alpha subunit only . ^^^ Treatment of BL cells with phorbol ester for 72 h induced expression of the beta subunit mRNA and the CD11a and CD 18 antigens on the cell surface . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The same protocol was performed after treatment of the MNC and mAb against LFA 1 ( CD11a ) or alpha E beta 7 ( CD 103 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of the intercellular adhesion molecule 1 ( ICAM 1 ) , and the integrins CD 49 , CD11b / c , and CD11a ( LFA 1 alpha chain ) was analyzed in an experimental model of pulmonary fibrosis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A flow cytometric analysis revealed that SN12C MM 3 showed a strong expression of sialyl Lewis 10 ( sialyl Le ( 10 ) ) carbohydrate antigen and a slightly stronger expression of CD11a ( LFA 1 alpha chain ) and CD 54 ( ICAM 1 ) compared with the other three cell lines . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Microglial cells were induced to express major histocompatibility ( MHC ) class 1 and class 2 antigens and small amounts of leukocyte function associated molecule 1 ( LFA 1 , CD11a ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Nucleosomes impaired neither the conjugation step nor the expression of adhesion molecules at the effector ( CD11a , CD 18 , CD 2 ) or target ( CD 54 , CD 58 ) cell surface . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Antibody blocking studies demonstrated that DC binding to untreated and TNF alpha treated endothelium was dependent upon the expression of CD11a , CD 18 and CD49d , and the simultaneous application of anti CD 18 and anti CD49d antibodies produced an approximate 70 % inhibition of adhesion ( P < 0 . 001 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The effect of p BQ appeared to be specific for IL 2 production , since de novo induction of the IL 2 receptor alpha chain ( CD 25 ) and ICAM 1 ( CD 54 ) and upregulation of LFA 1 alpha / beta ( CD11a and CD 18 ) were unaffected . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To better define the specific function of Mac 1 ( CD11b ) versus LFA 1 ( CD11a ) and the other CD 11 integrins in vivo , we have disrupted murine CD11b by targeted homologous recombination in embryonic stem cells and generated mice which are homozygous for a mutation in CD11b . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The autoreactivity in SLE has been elucidated in drug induced SLE : hypomethylation of DNA leads to overexpression of integrin CD11a / CD 18 , increased binding of T cells to macrophages and B cells , a higher rate of apoptosis of macrophages , and elevated B cell activity with consecutive production of autoantibodies . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
When the reactivity of mNKES and mouse mAbs recognizing the human adhesion associated antigen ( CD 10 , CD11a , CD11b , CD11c , CD 14 , CD 16 , CD 18 , CD 23 , CD 28 , CD 29 , CD 31 , CD 43 , CD 44 , CD45RA , CD 50 , CD 54 , CD 58 , CD 80 , CD 102 , CD 106 , and HLA class 1 , and HLA class 2 antigen ) with various cell lines was compared , mNKES reactivity was found to be unique , not resembling that of any of these mouse mAbs . ^^^ The mAbs reactive with CD11a / CD18 ( leukocyte function associated antigen 1 ; LFA 1 ) and CD 54 ( intercellular adhesion molecule 1 ; ICAM 1 ) completely blocked the IM 9 cell aggregation induced by mNKES , and induction of IM 9 cell aggregation by mNKES was significantly blocked in the presence of the protein kinase C inhibitors sphingosine and H 7 and completely blocked by cytochalasin B and cytochalasin D , which inhibit microfilament formation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The current study demonstrated that KLH IC ligation to either CR 2 or Fc gammaRII resulted in activation of a second co stimulatory molecule , LFA 1 ( CD11a , CD 18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of eight markers ( CD 16 , CD 18 , CD 32 , CD 44 , CD 71 , HLA Class 1 , HLA DR , and HLA DQ ) was significantly ( p < 0 . 05 ) higher on AM of AA than on N ; expression of six markers ( CD11a , CD 16 , CD 18 , CD 71 , HLA Class 1 , and HLA DR ) was higher on AM of AR than on N , with differences in CD 44 levels approaching statistical significance ( p = 0 . 07 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Keratinocytes were activated and expressed CD 54 ( intercellular adhesion molecule 1 ) ; perivascular lymphocytes were mostly CD2+ , CD3+ , and CD4+ and exhibited CD11a through CD 18 ( leukocyte function associated antigen 1 ) and often HLA DR and / or CD62L ( leukocyte endothelial cell adhesion molecule 1 ) ; and endothelial cells were activated with a strong expression of CD 54 ( intercellular adhesion molecule 1 ) , CD62E ( endothelial leukocyte adhesion molecule 1 ) , and CD 31 ( platelet endothelial cell adhesion molecule 1 ) in lesser amounts . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This process did not increase production of TNF alpha and did not change the surface expression of CD 18 , CD11a or CD11b . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
RESULTS : Conjunctival dendriform cells reliably expressed several antigens : class 2 antigens HLA DR and HLA DQ , CD1a , vimentin , CD11a and CD 18 ( LFA 1 ) , CD 14 , CD 22 , CD 36 , CD45RO , ICAM 3 and CD 63 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Among the beta 2 integrins , the levels of Mac 1 ( CD11b ) and p150 . 25 ( CD11c ) were positive , while LFA 1 ( CD11a ) was not detectable . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The HMC 1 cells clearly expressed CD11a , CD 18 and CD 54 , while expression of CD11b and CD11c was low . ^^^ The apparent molecular weights were 180 kDa ( CD11a ) , 95 kDa ( CD 18 ) and 90 kDa ( CD 54 ) as determined by Western blot analysis . ^^^ Phorbol myristate acetate ( PMA ) induced a time and dose dependent up regulation of CD11a , CD11b , CD11c , CD 18 and CD 54 that was inhibited by cycloheximide , suggesting a dependence on de novo protein synthesis . ^^^ Enhanced expression of CD11a , CD11b , CD11c and CD 18 could also be confirmed at the gene level as demonstrated by semi quantitative reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ Only LTB 4 was shown specifically to up regulate CD11a and CD 18 , but not CD11b or CD11c . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Exposure of NK cells to IL 2 and IL 12 augmented their adhesive ability , while IL 4 had an inhibitory effect . mAb directed against CD 18 and CD11a inhibited binding and migration of NK cells across resting or IL 1 activated EC , whereas anti CD11b and Cd11c did not . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Interestingly , anti CD11a alone did not inhibit cytotoxicity , anti CD 18 alone did only inhibit cytotoxicity moderately ( 25 % ) whereas anti CD11a and anti CD 18 in combination almost abrogated cytotoxicity against tumor targets P 815 and YAC 1 . ^^^ Finally we demonstrate that pre incubation of T LAK cells with anti bodies to CD11a and CD 18 in combination inhibited their migration into the B 16 tumors by more than 50 60 % . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
However , adhesion to myeloperoxidase was inhibited by monoclonal antibodies to alpha M ( CD11b ) or to beta 2 ( CD 18 ) integrin subunits , but not by antibodies to alpha L ( CD11a ) , alpha M ( CD11c ) , or to other integrins . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of CD11a ( alpha chain of lymphocyte function associated antigen 1 , LFA 1 ) on CD3+ cells in the BAL fluid of patients with sarcoidosis was not different from that of normal subjects . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Various truncated and chimeric forms of LFA 1 alpha ( CD11a ) and beta ( CD 18 ) chains were generated and transfected into murine fibroblast TNR 2 cells . ^^^ The role of LFA 1 ( CD11a / CD18 ) cytoplasmic domains in binding to intercellular adhesion molecule 1 ( CD 54 ) and in postreceptor cell spreading . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Up regulation of ICAM 1 was also observed following stimulation with other mAb specific for CD11a ( S6F1 ) , CD11b ( JML H 11 ) , and CD 18 ( IB 4 ) ; all of these mAb recognized members of the beta 2 integrin family , but not with isotype matched control mAb . ^^^ Stimulation with mAb YH 384 specific for LFA 1 alpha ( CD11a ) up regulated ICAM 1 expression on THP 1 cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Granulocyte and monocyte surface adhesion molecule expression was determined indirectly using a panel of monoclonal antibodies against CD11a , CD11b , CD11c , CD 18 , and L selectin in donor white blood cells exposed to patient plasma . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of two adhesion molecules , ICAM 1 ( CD 54 ) and ICAM 3 ( CD 50 ) , infiltrating cells positive for their ligand , LFA 1 ( CD11a ) , and the markers of total leukocytes ( CD 45 ) , T cells ( CD 3 ) , granulocytes / monocytes ( CD 15 ) , and macrophages ( CD 68 ) in renal interstitium were examined by an indirect immunoperoxidase method . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Eighteen of the mAbs to different human CD antigens ( CD11a , CD 14 , CD 18 , CD 21 , CD 27 , CD 29 , CD49a , CD49b , CD49d , CD49e , CD 51 , CD 61 , CD62L , CD62P , CD 63 , CDw 78 , CD 98 , CD 100 ) stained bovine antigens with an almost identical cellular distribution to that reported in humans . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The addition of mAb WT 1 against rat LFA 1 ( CD11a ) antigen had no effect on adhesion , suggesting that the cell cell interaction is not mediated by the expression of LFA 1 antigen . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD11a , the alpha chain of LFA 1 , which is a member of the LeuCAM family of integrins , has been implicated in the formation of HIV induced syncytia and may contribute to the depletion of CD 4 positive lymphocytes seen in patients with HIV infection . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD11a to c and CD 18 were distributed in bimodal form on DLGL , part of the cells being negative . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Surface expression of integrins was measured by FACS analysis in 19 healthy subjects ( 16 males , 3 females , 36 . 6 + / 8 . 7 years , 177 . 1 + / 7 . 5 cm , 70 . 3 + / 8 . 1 kg ) before and after submaximal exercise ( 3 h run ) using monoclonal antibodies against cd11a , cd11b , cd11c , cd 18 , cd 29 and cd 49 . ^^^ Nevertheless , the expression ( indicated by the mean log fluorescence ) of cd11a ( 94 + / 24 vs . 78 + / 14 ) and cd 18 ( 128 + / 31 vs . 102 + / 21 ) on lymphocytes and of cd11a ( 104 + / 25 vs . 85 + / 16 ) , cd11c ( 497 + / 171 vs . 408 + / 126 ) cd 29 ( 109 + / 16 vs . 89 + / 16 ) , cd 49 ( 69 + / 8 vs . 54 + / 11 ) on monocytes was decreased after exercise ( all P < 0 . 05 ) . ^^^ Since leucocyte adhesion is mediated by integrins , we tested the hypothesis that surface expression of the integrin adhesive receptors LFA 1 ( cd11a / cd18 ) , MAC 1 ( cd11b / cd18 ) , gp 150 / 95 ( cd11c / cd18 ) , and VLA 4 ( cd29 / cd49 ) is decreased by moderate endurance exercise . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A panel of monoclonal antibodies against CD11a , CD11b , CD11c , CD 18 and L selectin was used . ^^^ RESULTS : The expression of CD11a adhesion molecules only showed slight variations regarding granulocytes , but was more pronounced on monocytes , however , without significant differences between the two patient groups , CD11b , CD11c and CD 18 molecules on both granulocytes and monocytes were significantly upregulated 60 min after the endovascular procedure compared to conventional aneurysm repair , and L selectin molecules were by this time correspondingly cleaved off . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast , Pro alpha 1 was equally effective by increasing the expression of CD 18 and CD11a on lymphocytes from the patients and from normal controls . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
No cross reactions were detected with mAbs against CD11a and CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
On alveolar macrophages obtained after the release of aortic cross clamp , macrophages as compared with alveolar macrophages obtained before cardiopulmonary bypass , there was a significant enhancement of CD11a , CD11b , CD11c , and CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The panel included probes specific for the CD 45 , CD 34 , P glycoprotein ( mdr 1 ) , Ly 6A / E ( Sca 1 ) , heat stable antigen ( CD 24 ) , Fc receptor for IgG FcgammaRII ( CD 32 ) , CD 44 , CD 22 , and ICAM 1 ( CD 54 ) genes , as well as alphaL ( CD11a ) , alphaM ( CD11b ) , beta 2 ( CD 18 ) , alpha 4 ( CD49d ) , alpha 5 ( CD49e ) , beta 1 ( CD 29 ) , and beta 7 integrin subunit sequences . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
First , CD45RA CD45R0 ( + ) cells are reminiscent of memory type T cells in that they express elevated levels of CD 95 ( Fas ) and the integrin family members CD11a , CD 18 , CD 29 , CD49d , and CD49e , compared to naive CD8+ T cells , and are able to secrete not only interleukin ( IL ) 2 but also interferon gamma , tumor necrosis factor alpha , and IL 4 . ^^^ The CD8+CD45RA+CD27 population contains T cells expressing high levels of CD11a , CD11b , CD 18 , and CD49d , whereas CD62L ( L selectin ) is not expressed . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expressions of CD11b , CD 18 and CD 54 , but not CD11a or CD11c , were higher on monocytes freshly isolated by density gradient separation and plastic adherence as compared with cells labelled directly in whole blood . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
MS HBECs were isolated from a surgical specimen obtained from an MS patient undergoing brain surgery for vascular aneurysm . 48 h after the first single administration of beta IFN 1b , PBMNCs of 10 MS patients were analyzed for HLA DR , CD11a , CD 18 and VLA 4 expression and the adhesion between PBMNCs and both stimulated and unstimulated MS HBECs evaluated . sICAM 1 and sVCAM 1 dosage in the serum of the patients was checked as well . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition , the number of conjugates and the expression of some adhesion molecules ( CD11a , CD11b , CD 18 , CD 2 , and CD62L ) were not modified by ox LDL . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Microsequencing of tryptic peptides from the two proteins showed complete homology with CD11a and CD 18 , the two subunits of the beta 2 integrin , lymphocyte function associated antigen 1 ( LFA 1 ) . ^^^ Anti CD11a and CD 18 monoclonal antibodies also inhibited RTX toxin mediated cytolysis . ^^^ Transfection of CD11a and CD 18 integrin genes into a cell line ( K 562 ) that is not sensitive to either RTX toxin resulted in LFA 1 expressing cells , KL / 4 , that were sensitive to both toxins . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monocyte expression of Fc gammaRI , Fc gammaRII , Fc gammaRIII , CD11a , CD11b , CD 18 , and HLA DR also significantly increased with peak expression at 48 hours . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Antiadhesion antibodies specific for the alpha chain of the leukocyte function associated antigen 1 ( LFA 1 , CD11a ) and the CD 2 molecules were infused pre BMT and post BMT to help prevent graft rejection , in addition to a conditioning regimen of busulfan ( BU ) , cyclophosphamide ( CP ) , and etoposide ( VP 16 ) or antithymocyte globulin ( ATG ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We also observed up regulation of homing receptors containing LFA 1 ( CD11a ) and alpha 4 ( CD49d ) on GT CD 4 cells over the course of infection . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This proliferative response was markedly inhibited by mAbs against human class 1 MHC , class 2 MHC and CD 4 antigens , and partially inhibited by mAbs against integrin beta 2 subunit ( CD 18 ) and LFA 1 ( CD11a ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
There was decreased percentage expression of CD11a , CD 18 , and ICAM 3 in Crohn ' s disease and ulcerative colitis compared with normal , but an increased MFI for these molecules among patients with Crohn ' s disease . ^^^ CD11a and CD 18 histograms typically had two peaks of expression . ^^^ We hypothesize that the decreased percentage expression and increased MFI of CD11a , CD 18 , and ICAM 3 may suggest that cells up regulate these ligands following activation and are egressing into tissue . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
It could be reduced with monoclonal antibodies ( MoAbs ) against CD11a and CD 18 on IFN gamma or TNF alpha activated HUVEC but was generally enhanced after treatment of HUVEC with MoAbs against CD 54 , CD62E , or CD 106 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
At least two intravascular monocyte subsets , probably central and marginating cells , were distinguished by their size and differential expression of CD 43 , CD 4 , CD11a , CD 18 , and L selectin . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Feeding the FO diet significantly reduced both the proportion of CD 2 positive L DC and the level of CD 2 expression on L DC compared with feeding each of the other diets ; the proportions of L DC staining positive for CD 40 , CD 18 , CD 54 , CD11a , and MHC 2 were unaffected by diet . ^^^ However , FO feeding reduced the level of expression of CD 18 , CD11a , MHC 2 , and CD 54 on L DC compared with feeding the other two diets ; the level of expression of CD 40 was unaffected by diet . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We also studied fluctuations in CD11a and CD 18 levels on lymphocytes and monocytes , as well as changes in serum sICAM 1 and sVCAM 1 concentrations . ^^^ A tendency to increase in both CD11a and CD 18 on the surface of lymphocytes was detected , while an increase in serum sVCAM 1 was seen at 3 h . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Increased adhesiveness was not associated with an abnormal expression of CD11a , CD11b , CD11c , CD 18 , CD62L , or CD 15 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The absence of changes in the expression of vascular cell adhesion molecule , integrin ligands ( CD11a , CD 18 , integrin alpha 4 ) , and sialyl Lewis 10 indicates a specific effect of soluble E selectin on ICAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We have studied the post injury expression of the lymphocyte , monocyte and neutrophil adhesion molecules CD11a ( LFA 1 ) , CD11b , CD11c , CD 29 ( beta 1 integrin ) and CD62L ( L selectin ) in a group of 36 trauma patients , 13 of whom had suffered major trauma ( ISS > or = 16 ) , 15 moderate trauma ( ISS = 9 15 ) and eight minor trauma ( ISS < 9 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
By immunhistology , alveolar , interstitial CD11a , CD 18 and VLA 4 positive leukocytes were counted . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Both BCP 1 and HBL 6 cells lack expression of important cytoadhesion molecules including CD11a and CD 18 ( LFA 1 alpha and beta chains ) , CD 29 , CD 31 , CD 44 , CD 54 ( ICAM 1 ) , and CD62L and E ( L and E selectins ) . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Immunohistochemistry was performed for CD 18 , CD11a , CD11b , CD11c , alphad , ICAM 1 , ICAM 2 , and ICAM 3 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In this study the contact between leukocytes and uncoated polyethylene terephthalate or pyrolytic carbon coated polyethylene terephthalate ( PET and PET PC , respectively ) was inspected by analyzing whether the expression of some adhesion molecules involved in leukocyte activation , namely LFA 1 ( CD11a / CD 18 ) , Mac 1 / CR3 ( CD11b / CD18 ) , and LECAM 1 ( CD62L ) can be modified . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In the lungs , the percentage of human leucocytes expressing the alpha chain of the lymphocyte function associated antigen 1 ( LFA 1 ) ( CD11a ) was higher than those of CD49d+ or CD54+ cells , in contrast to the spleen and thymus , suggesting a potential role of LFA 1 in the human cell migration towards SCID mice lung . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Previous studies have shown that triggering multiple myeloma ( MM ) cells via CD 40 induces IL 6 mediated autocrine growth as well as increased expression of cell surface adhesion molecules including CD11a , CD11b , CD11c , and CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD11a ( the beta 2 integrin LFA 1 ) was expressed on > 95 % of all leukocytes and these data were thus similar to the overall leukocytosis data . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In this paper we describe the age dependent development of components involved in major maturational processes , including the appearance and varying expression of adhesion receptors ( CD11a , CD 18 , CD 28 , CD 29 , CD 44 , CD49d and CD 54 ) on CD4+ `` helper ' ' cells and CD8+ `` suppressor and cytotoxic ' ' cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of CD11a , CD11b and CD 18 on neutrophils was assessed by immunofluorescence flow cytometry 30 min after the stimulation of neutrophils with 10 ( 7 ) M platelet activating factor ( PAF ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The CD4 / 18 chimera did not affect the expression of endogenous LFA 1 or the association of CD11a and CD 18 . ^^^ The cytoplasmic domains of LFA 1 ( CD11a / CD18 ) are thought to play an important role in the regulation of LFA 1 function . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of CD 29 , CD 61 , CD 18 and CD11a on platelets was examined by flow cytometry in mice treated with leukaemia inhibitory factor ( LIF ) or megakaryocyte growth and development factor ( PEG rHuMGDF or mpl ligand ) . ^^^ These treatments decreased the expression of CD11a and CD 18 , whereas that of CD 29 or CD 61 was not markedly changed . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of CAM was analyzed by flow cytometry using monoclonal antibodies against CD49d , CD 29 , CD11a , CD11b , CD11c , CD 18 , CD62L , CD 54 and CD 44 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : Using immunofluorescence phenotyping and flow cytometry , the expression of leukocyte adhesion molecules CD 54 , CD11a , CD11b and CD 18 in peripheral blood were measured within 12 h after onset of ischemia in 20 patients with stroke . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Analysis of NKR P 1 ( CD 161 ) , CD 4 , CD62L , CD 43 , CD11a , CD 18 and MHC class 2 expression identified at least two monocyte populations in all experimental groups . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This study examined interaction of the CD11a , CD11b , and CD 18 subunits of the beta 2 integrin with ICAM 1 , transfected into Chinese hamster ovarian ( CHO ) cells to avoid effects of other adhesion molecules . ^^^ Blockade with a monoclonal antibody ( MAb ) to ICAM 1 or MAbs to CD11a , CD11b , or CD 18 reduced PMN mediated cytotoxicity to baseline . ^^^ To examine the role of adhesion in cytotoxicity , we studied beta 2 integrin mediated PMN adhesion to ICAM 1 transfected CHO cells and found that MAbs for CD11a , CD11b , and CD 18 all abrogated PMN cytotoxicity despite disparate effects on adhesion . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Major histocompatibility complex ( MHC ) class 1 , CD 29 , CD49d , and CD 51 were present on all stromal cell lines , MHC class 2 and CD 34 were consistently absent , and CD11a ( LFA 1 ) , CD 18 ( ICAM 1R ) , CD 54 ( ICAM 1 ) , CD 58 ( LFA 3 ) CD 56 ( N CAM ) , CD 106 ( 5 CAM ) , laminin , and collagen 4 were diversely expressed . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The morphology , phagocytic activity , production of hydrogen peroxide ( H2O2 ) and expression of lymphocyte function associated antigen 1 ( LFA 1 ; CD11a / CD18 ) , complement receptor type 3 ( CR 3 ; CD11b / CD18 ) , p 150 , 95 ( CD11c / CD18 ) , and platelet / endothelial cell adhesion molecule 1 ( PECAM 1 ; CD 31 ) by oral polymorphonuclear neutrophils ( PMN ) are assessed and the results compared with those of blood PMN . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The cell surface expression of the integrin proteins CD11a , CD11b , CD 18 and CD 29 on neutrophils was assayed by means of flow cytometry . ^^^ No differences were seen between patients and controls in cell surface expression of the integrin proteins CD11a , CD11b , CD 18 and CD 29 on neutrophils , nor was there any difference in these parameters between patients with and without extra glandular symptoms . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Altered expression of adhesion molecules CD 44 , CD 54 ( case 1 ) and CD11a and CD 18 ( case 2 ) may help to explain the poor outcome of these patients . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of CD11b , CD11c , and CD 18 on human neutrophils after G CSF treatment increased , but CD11a did not . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Lymphoid lineage markers included CD20 / CD22 coexpressed on 89 % of cells , CD 71 ( 70 % ) , CD11a ( 48 % ) , CD 18 ( 54 % ) , and surface lambda light chain ( 33 % ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Antibodies to LFA 1 ( CD11a ) , Mac 1 ( CD11b ) or CD 18 reduced neutrophil accumulation by 62 percent , 59 percent and 86 % , respectively , while anti VLA 4 was without effect . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A bispecific antibody was developed by somatic cell hybridization of two hybridomas , one producing a monoclonal antibody against the immunoglobulin idiotypic determinant of the murine B cell lymphoma 38C 13 and the other producing an antibody against the alpha subunit ( CD11a ) of the adhesion molecule LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The fish oil diet decreased the level of expression of CD 2 , CD11a , CD 18 and CD 44 on the surface of freshly prepared lymphocytes and of CD 2 , CD11a , CD 18 , CD 54 ( intercellular adhesion molecule 1 ; ICAM 1 ) and CD62L ( L selectin ) on the surface of concanavalin A ( Con A ) stimulated lymphocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Using a binding assay with 125I labeled fimbriae , we observed that fimbrial binding to the macrophages was inhibited by treatment with CD11a , CD11b , CD11c , or CD 18 antibody but not by that with CD 29 antibody . ^^^ Furthermore , Northern blot analyses showed that the fimbria induced expression of IL 1beta and TNF alpha genes in the cells was inhibited strongly by CD 18 antibody treatment and slightly by CD11a , CD11b , or CD11c antibody treatment . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of intercellular adhesion molecule 1 ( ICAM 1 ) , the ligand leucocyte function antigen 1 ( LFA 1 , CD11a ) , and complement receptor type 3 ( CR 3 , or Mac 1 , CD11b ) has been studied in murine kidneys acutely infected with the fatal malaria parasite Plasmodium berghei ANKA . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CBDC expressed the CD 4 , CD11a , CD 18 , CD45RA , CD 50 and CD 54 antigens but revealed no expression of the CD1a , CD11c , CD 40 , CD45R0 , CD 58 , CD 83 , CD 86 and CD 102 antigens . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The surface expression of CD11a , CD11b , CD 18 and VLA 4 adhesion molecules on normal human eosinophils were not modulated by eotaxin stimulation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We report lesser expression of CD11a ( LFA 1 ) and L selectin ( CD62L ) on the circulating neutrophils of HIV+ subjects compared with HIV controls . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
By extensive mutagenic analysis of the inserted domain ( 1 domain ) of the alpha chain ( CD11a ) of the leukocyte function associated antigen 1 ( LFA 1 ) , we have defined a putative binding surface for intercellular adhesion molecules 1 and 2 ( ICAM 1 and 2 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
METHODS : IEL and LPL were obtained from 18 CD patients and 20 controls by enzymatic extraction , and subsequently characterized by flow cytometry for CD 3 , CD 4 , CD 8 , CD 25 , LFA 1 alpha ( CD11a ) , CD 44 , alpha 4 and alpha E beta 7 integrin . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
However , we herein report that anti REC CTL uniquely express CD 103 , an integrin with known specificity for the epithelial cell restricted ligand E cadherin , and are deficient in expression of CD11a ( LFA 1 ) , an integrin known to play a critical accessory role in promoting lysis of LC targets . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We investigated the expression of adhesion molecules ( CD11a , CD11b , CD 18 , CD 31 , CD 54 , and CD62L ) on neutrophils from nasopharyngeal aspirates ( NPAs ) and peripheral blood ( PB ) of infants with respiratory syncytial virus ( RSV ) induced bronchiolitis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
No significant differences were noted between patients and normal controls in the proportions of neutrophils carrying the cell adhesion molecules CD11a / CD 18 , CD 15 and CD62L . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
However , it was inhibited by approximately 75 % by monoclonal antibodies to CD49d ( VLA 4 ) or CD11a ( LFA 1 ) but was not significantly affected by an antibody to CD11b ( Mac 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Flow cytometric analysis for CD11a , CD11b , and CD 18 expression was examined . ^^^ RESULTS : Ibudilast had an inhibitory effect on beta 2 integrin expression induced by PAF [ CD11a : 84 . 8 % versus 73 . 1 % ( preincubation with ibudilast ) , CD11b : 35 . 8 % versus 26 . 2 % , CD 18 74 . 9 % versus 65 . 6 % ] . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of PE CAM 1 ( CD 31 ) on monocytes and LFA 1 ( CD11a ) on lymphocytes was increased with age . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We studied the expression adhesion molecules CD11a , CD 18 , CD 44 , CD 54 and CD62L on the thoracic duct lymphocytes of rats treated with CsA . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We induced beta 2 integrin cross linking by plating PMN onto surface bound mAbs directed against either the common beta chain ( CD 18 ) or the individual alpha chains ( CD11a , CD11b , CD11c ) of LFA 1 , CR 3 , and gp150 / 95 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
During reperfusion , CD11b and CD 18 , but not CD11a , were upregulated on neutrophils [ bronchoalveolar lavage ( BAL ) and blood ] and lung macrophages . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The tumors showed immunoreactivity for CD 18 , CD 29 , and CD49d , but not for CD11a , mimicking the phenotype of human Epstein Barr virus ( EBV ) related lymphomas . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Despite the high level of cellular activation and proliferation induced by PMVEC coculture , the surface expression of adhesion molecules CD11a ( LFA 1 ) , CD11b , CD15s ( sialyl Lewis 10 ) , CD 43 , and CD 44 ( HCAM ) on the total CD34+ population was maintained , and the surface expression of CD49d ( VLA 4 ) , CD 54 ( ICAM ) , CD 58 , and CD62L ( L selectin ) increased after ex vivo expansion . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of the majority of the cell surface proteins studied was unaffected by HIV infection ( HLA class 1 , 2 , CD11a , CD 18 , CD 25 , CD 27 , CD 28 , CD 29 , CD 30 , CD 31 , CD 38 , CD 44 , CD45R0 , CD49d , CD 57 , CD 94 , CD 95 , and CXCR 4 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of adhesion molecules on CD34+ cells revealed a significant reduction of CD11a ( P = 0 . 009 ) , CD 18 , CD49d and CD62L ( P < 0 . 0001 ) at days 4 and 6 , compared to the baseline level . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Immunohistochemistry was performed using the APAAP method and directing specific mouse anti human monoclonal antibodies against ICAM 1 ( CD 54 ) , VCAM 1 ( CD 106 ) , E selectin ( CD62E ) , alpha LFA 1 ( CD11a ) , alpha Mac 1 ( CD11b ) , alpha p150 / 95 ( CD11c ) and the beta 2 integrin chain ( CD 18 ) . ^^^ CD 18 , LFA 1 ( CD11a ) , Mac 1 ( CD11b ) and p150 / 95 ( CD11c ) were markedly expressed on infiltrating immunocytes in HTX compared to CABG where no expression of beta 2 integrins was observed . ^^^ CD 18 , LFA 1 ( CD11a ) , Mac 1 ( CD11b ) and p150 / 95 ( CD11c ) were markedly expressed on infiltrating immunocytes in HTX compared to CABG where no expression of beta 2 integrins was observed . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast , DC expression of leucocyte function associated 1 ( LFA 1 , CD11a ) , Mac 1 ( CD11b ) , integrin beta 2 chain ( CD 18 ) and the DEC 205 receptor increased , while CD 40 levels were relatively unchanged 24 h after the treatment . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
RESULTS : NK cell adhesion to TNF a treated PAEC increased in a dose dependent manner by a maximum of 44 % , and was inhibited by mAbs against CD49d , CD11a , CD11b , CD 18 , and CD 2 , as well as porcine vascular cell adhesion molecules . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Neutrophil expression of CD11a , CD11b , and CD 18 was monitored by flow cytometry . ^^^ An increase in CD11b and CD 18 and a decrease of CD11a on neutrophils in parallel with complement activation was observed . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Critical role of CD11a ( LFA 1 ) in therapeutic efficacy of systemically transferred antitumor effector T cells . ^^^ In this study , the requirement of cell adhesion molecules , CD11a / CD18 ( LFA 1 ) , CD 54 ( ICAM 1 ) , CD49d / CD29 ( VLA 4 ) , and CD 106 ( VCAM 1 ) , for T cell infiltration into tumors and antitumor function was investigated . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CBDC expressed CD 4 , CD11a , CD 18 , CD45RA , CD 50 , CD 54 , and CD 123 , but showed no expression of CD1a , CD11c , CD 33 , CD 40 , CD45R0 , CD 80 , CD 83 , and CD 86 and only limited expression of CD 58 , CD 102 , and CD 116 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Mean fluorescence intensity of CD11a ( integrin alpha chain subunit of lymphocyte function antigen 1 , LFA 1 ) on lymphocytes transiently but significantly decreased , suggesting a mechanism for transient alteration of lymphocyte trafficking . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of the beta 2 integrins CD11a , CD11b and CD 18 , of CD 35 ( CR 1 ) , and of Fc gamma RII and Fc gamma RI ( CD 32 and CD 64 ) on monocytes was elevated in the RA patients compared with healthy controls , while the expression of the beta 1 integrins ( CD 29 , CD49d , CD49f ) was unaffected . ^^^ After 4 6 weeks of treatment with low dose prednisolone , the expression on the monocytes of CD11a , CD11b , CD 18 , CD 35 , CD 32 and CD 64 was normalized . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The CD1a+ cells reacted with antibodies against protein S 100 , HLA DR , the Lag antigen , CD 4 , CD11a , CD11b , CD 18 , CD 25 , CD 40 , CD 54 , CD 80 and CD 86 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies ( mAb ) to the known accessory molecules CD11a , CD 18 , CD 54 and CD 45 , all inhibited T cell proliferation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Although leukocyte infiltration was not normally detected by monoclonal antibodies for CD11a and CD 18 , it became remarkably evident at 1 day of MCAO . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Thus , HCL is characterized by high CD 54 , CD 44 , VLA 4 , CD11c , and CD 18 and by low or absent CD11a and L selectin , whereas FL confined to the lymph nodes is characterized by high CD11a , CD 18 , and CD 54 expression . ^^^ Cases with splenomegaly as their prominent feature bear high CD11a , CD 18 , CD 29 , and CD11c on the surface of the leukemic cells . ^^^ The main AM studied either by immunohistochemistry on lymph node sections or by flow cytometry in blood and bone marrow specimens are L selectin , CD11a / CD18 ( LFA 1 ) , CD 54 ( ICAM 1 ) , CD 44 ( HCAM ) , CD11c / CD18 ( gp150 / 95 ) , and CD49d / CD29 ( VLA 4 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Although CD49d and CD 90 participated in both cases , CD11a , CD 18 , and CD 2 receptors played a dominant role in the adhesion of T cells to thymic epithelium only . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In a retrospective immunohistochemical study based on 27 patients with stage 4 follicle center lymphoma ( FCL ) the expression of CD44standard ( CD44s ) , LFA 1 ( CD11a , CD 18 ) , VLA 4 ( CD49d , CD 29 ) and ICAM 1 ( CD 54 ) was analysed on lymphoma cells in bone marrow infiltrates . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies against CD 54 , CD11a , and CD 18 significantly inhibited the cytolysis , indicating that the killing involves the engagement of CD 54 with its ligands . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Study design : Expression of LFA 1 was measured by flow cytometry using monoclonal antibodies directed against CD11a and CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The effect of recombinant bovine somatotropin ( bST ) on the chemiluminescence , diapedesis , and expression of adhesion receptors ( CD11a , CD11b , CD 18 ) of isolated polymorphonuclear leukocytes was studied . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We have also found a significant increased expression of CD11a , CD 18 and CD 54 antigens on granulocytes , and higher percentage CD11b+CD18 ( + ) granulocytes out of all granulocytes in MS patients compared with control . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The phenotypic analysis indicates that these cells are more similar to mature macrophages than 2A10 monocytes . 2A10+ monocytes express higher levels of swine histocompatibility leukocyte Ag 2 , CD 16 , and the adhesion molecules very late Ag 4 ( CD49d ) and LFA 1 ( CD11a ) than 2A10 monocytes , while CD 14 and SWC 1 expression is lower . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We have also tested the effect of beta endorphin and met enkephalin on CD11a , CD11b , CD 18 and CD 16 molecule expression on PMN in vitro . ^^^ To assess the effect of opioid peptides on CD11a , CD11b , CD 18 and CD 16 molecule expression the whole blood samples were incubated with different concentrations of the opioids , then the white cells were labelled with respective PE conjugated MoAb and evaluated by flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Both alphaL ( CD11a ) and beta 2 ( CD 18 ) were reduced in CD 8 ( + ) TIL but not in CD 4 ( + ) TIL . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In the present study the changes expression of adhesion molecules CD11a , CD 18 ( LFA 1 ) , CD 54 ( ICAM 1 ) and L selectin ( CD62L ) and VLA 4 ( CD49d ) were analysed by flow cytometry . ^^^ The most significant finding was a significant decrease of ICAM 1 expression on monocytes and CD49d on monocytes and lymphocytes as well as an increase of L selectin expression on monocytes after treatment with DSCG , without any associated effect on CD11a and CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
PMN apoptosis was assessed every 6 hours with use of propidium iodide DNA staining and PMN function was assessed with use of respiratory burst activity , phagocytosis ability , and CD11a , CD11b , and CD 18 receptor expression as functional markers . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Similarly , both alphaL ( CD11a ) and beta 2 ( CD 18 ) were down regulated in TIL and LPL with CD8+ cytotoxic phenotype , but not in those with CD4+ phenotype . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Ten patients with multiple sclerosis and treated with interferon beta1b ( IFN beta1b ) were followed up for 1 year with quantitation of serum VCAM 1 and ICAM 1 levels , mean fluorescence intensity of HLA DR , VLA 4 , CD11a , and CD 18 on peripheral blood monocytes and lymphocytes , and adhesion of peripheral blood monocytes and CD45+ cells on endothelial cell monolayers . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : We tested the ability of the EG MPHA to detect granulocyte antigens using 5 human antibodies specific for NA 1 , NA 2 , NB 1 , 5b , and Sar ( a ) , and 8 different monoclonal antibodies for NA 1 , CD11a , CD11b , CD 13 , CD 16 , CD 18 and HLA class 1 . ^^^ RESULTS : NA 1 , NA 2 , NB 1 , 5b , Sar ( a ) , CD11a , CD11b , CD 13 , CD 16 , CD 18 and HLA class 1 antigens were present in the extracted granulocyte antigen preparation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The purified proteins reacted specifically with monoclonal antibodies specific for CD11a , CD11b , CD11c ( the alpha chains of beta ( 2 ) integrins ) , and CD 18 ( the beta chain of beta ( 2 ) integrins ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
RESULTS : Flow cytometric analysis showed that pit cells expressed CD 2 , CD11a , CD 18 and CD 54 . ^^^ Treatment of freshly isolated pit cells with monoclonal antibodies ( mAbs ) to CD11a and CD 18 inhibited not only the pit cell mediated CC531s cytolysis but also the pit cell induced apoptosis of CC531s cells . ^^^ The combination of mAbs to CD11a , CD 18 and CD 54 further increased the inhibition of pit cell mediated CC531s cytolysis and apoptosis . ^^^ The binding of pit cells to CC531s cells was also inhibited by anti CD11a , and CD 18 mAbs , but not by anti CD 2 mAb . ^^^ CONCLUSIONS : These results indicate that CD11a / CD18 ( LFA 1 ) present on pit cells plays an important role in pit cell mediated target cell adhesion , lysis and apoptosis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Acute stress induced a decrease in NK cell expression of CD 2 ( 17+ / 3 % ) ; and to a lesser degree induced a decrease in expression of LFA 1 ( CD11a : 8+ / 3 % ; CD 18 : 7+ / 3 % ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We analyzed the role of ICAM 1 , CD 18 , CD11a , CD11b , and CD11c during episodes of rejection or infection in patients after lung transplantation and compared the results to episodes without apparent complication . ^^^ ICAM 1 , CD 18 , CD11a , CD11b , and CD11c expressions were detected immunocytochemically on alveolar macrophages . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Using flow cytometry , we found an increased expression of adhesion molecules CD62L , CD 18 , CD11a , CD11b , CD49d and CD 54 in the exposed workers as compared with the control group ( P < 0 . 05 ) . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
These include : CD11a , CD 18 , CD 29 , CD 34 , CD 45 , CD49d , CD49e , and CD62L . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Blocking ICAM 1 ( CD 54 ) and LFA 1 ( CD11a ) inhibits experimental allergic conjunctivitis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Regarding other adhesion molecules on EoL 1 ( CD11a , CD 18 , CD49d ) , the expression was not significantly augmented by adherence to FN . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The blood was incubated with neutralizing monoclonal antibodies to CD 18 , CD11a , CD11b , CD 29 , CD49d , CD 54 , alpha4beta7 , or isotype matched control antibodies , respectively , at 4 degrees C for 30 min . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expanded CD8+ cells maintained their initial level of expression of CD 3 , CD11a , CD 18 and T cell receptor ( alphabeta heterodimer , TCR ( alphabeta ) ) but increased expression of CD45RO , CD 95 and of activation markers HLA DR and CD 25 in each culture vessel . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Structural basis for LFA 1 inhibition upon lovastatin binding to the CD11a 1 domain . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD11a ( leukocyte integrin LFA 1 alpha subunit ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
METHODS : Whole blood and SF cells were stained with monoclonal antibodies against CD11a ( LFA 1 ) , CD 15 s ( sialyl Lewis 10 ) , CD 44 , CD 54 , VLA 4 , and HLA DR counterstained with anti CD 14 antibodies as a Mphi marker for dual fluorescence analysis by flowcytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of LFA 1 on the decidual CD 56 ( bright ) NK cells was analysed using flow cytometry with fluorescent monoclonal antibodies ; CD 56 ( NKH 1 ) , CD 16 ( Fcg R 3 ) and CD11a ( LFA 1 alpha chain ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LFA 1 ( CD 18 , CD11a ) is a cell adhesion molecule that mediates critical immunological processes . ^^^ LFA 1 ( CD 18 , CD11a ) is a cell adhesion molecule that mediates critical immunological processes . ^^^ In this paper we report the discovery and characterization of ( R ) 5 ( 4 bromobenzyl ) 3 ( 3 , 5 dichlorophenyl ) 1 , 5 dimethylimidazolidine 2 , 4 dione ( BIRT 377 ) , an orally bioavailable small molecule that interacts specifically with LFA 1 via noncovalent binding to the CD11a chain and prevents LFA 1 from binding to its ligand , ICAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : The expression of alpha 2 through alpha 6 and beta 1 common chains of very late activation antigen ( VLA ) molecules and alphaL ( CD11a ) and beta 2 common ( CD 18 ) chains of leukocyte function associated antigen 1 molecule were studied in 137 patients with NHL . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The results demonstrate for the first time that Lkt binds to bovine CD11a and CD 18 ( lymphocyte function associated antigen 1 [ LFA 1 ] ) . ^^^ The binding was abolished by anti CD11a or anti CD 18 monoclonal antibody ( MAb ) . ^^^ Lkt induced calcium elevation in bovine alveolar macrophages ( BAMs ) was inhibited by anti CD11a or anti CD 18 MAb ( 65 to 94 % and 37 to 98 % , respectively , at 5 and 50 Lkt units per ml ; P < 0 . 05 ) . ^^^ Lkt induced cytolysis in neutrophils and BAMs was also inhibited by anti CD11a or anti CD 18 MAb in a concentration dependent manner . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The two subunits of LFA 1 , CD11a and CD 18 , showed decreased surface expression on lymphocytes from pertussis toxin treated animals compared to untreated animals . ^^^ Lower surface expression of CD11a and CD 18 was observed on all lymphocyte subsets and was correlated inversely with the extent of lymphocytosis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast to CD62L , the surface density of the beta 2 integrin LFA 1 ( CD11a ) was higher on circulating lymphocytes ( p < 0 . 001 ) ( but not monocytes or lymphocytes ) post infusion . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Several integrin molecules potentially involved in this process , i . e . , CD 29 , CD 18 , CD11a , CD11b and CD11c , were therefore studied by fluorescence activated cell sorting analysis . ^^^ Among the beta 2 integrins , the expression of LFA 1 ( CD11a ) and of Mac 1 ( CD11b ) , but not of p 150 , 95 ( CD11c ) , was induced by RA . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The studies revealed that the integrins CD11a , CD11b , CD 18 , CD49d , and CD 61 , as well as the additional adhesion receptors CD 54 , CD62L , and the transferrin receptor CD 71 were expressed on day 11 of gestation to various degrees on these embryonic cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
No such differences were found in CD11a molecule of LFA 1 integrin expression on lymphocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
It was not inhibited by antibodies to CD 18 , CD 29 , CD 2 , CD11a and CD11b . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Immunoreactivity of postreperfusion cardiac lymph with R15 . 7 ( anti CD 18 ) or MY 904 ( anti CD11b ) was positive in all animals but not for CD11a ( R7 . 1 ) , indicating a specific loss of Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Extracellular release of free fatty acids by rat T lymphocytes is stimulus dependent and is affected by dietary lipid manipulation . [ ( 3 ) H ] Arachidonic acid labelled rat T lymphocytes released radioactivity extracellularly when stimulated by the calcium ionophore A 23187 or by monoclonal antibodies to some cell surface structures ( CD 2 , CD 5 , CD11a , CD 18 , CD 54 , T cell receptor ) but not to others ( CD49d , CD62L ) ; release was greater with the calcium ionophore . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
BACKGROUND : CD11a / CD18 comprise subunits of leukocyte function associated antigen ( LFA 1 ) , a T cell surface molecule important in T cell activation , T cell emigration into skin , and cytotoxic T cell function . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The aim of the present study was to evaluate the expression of lymphocyte function associated antigen 1 alpha ( LFA 1 alpha , CD11a ) and L selectin ( CD62L ) molecules on peripheral mononuclear cells in Graves disease and type 1 diabetes in comparison to healthy controls , since they were shown to play an important role in lymphocytes and / or monocytes migration into the organs affected by immune process and are suggested to contribute to the pathogenesis of Graves disease and type 1 diabetes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We have studied binding of fluorescein isothiocyanate ( FITC ) stained TNF alpha by PMN , the expression of CD11a , CD11b , and CD 18 molecules of beta 2 integrines and the expression of CD 10 ( neutral endopeptidase NEP ) and of CD 13 ( aminopeptidase N ; APN ) antigens on PMN in three different groups of MS patients . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of CD 14 , CD11a , CD 18 , CD 15 and CD 29 on uninfected and RSV infected THP 1 cells was assessed by flow cytometry in relation to differences in bacterial binding . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The Jurkat cell aggregation was not blocked by addition of CD11a ( LFA 1 ) and CD 54 ( ICAM 1 ) mAbs . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The antigens recognized by R 1 73 , R 2 40 and R 1 34 mAbs were defined by immunoprecipitation and Western blot analyses as CD11a , CD 18 and CD11b , respectively ; and the allografts expressed CD 54 , a ligand of CD11a or CD11b , suggesting leukocyte integrin dependent killing . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A simple culture system devoid of antigen presenting cells was used to examine the ability of immobilized antibodies to lymphocyte function associated antigen 1 ( LFA 1 ) ( CD11a ) , CD 28 and CD 4 or CD 8 to modulate the responses of normal murine CD4+ and CD8+ lymph node T cells to immobilized anti CD 3 antibody and interleukin 2 ( IL 2 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD11a , CD11b and CD 18 , measured by flow cytometry , were elevated in the non surviving group , the septic shock group and the multiple organ dysfunction syndrome group , suggesting a close connection between these adhesion molecules and burns complicated by infection . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Mobilization can be specifically prevented by pretreatment with antibodies against the beta 2 integrin LFA 1 ( CD11a ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The purpose of this study was to determine whether transient therapy directed against the adhesion molecule LFA 1 ( CD11a ) was sufficient to induce donor specific tolerance to pancreatic islet allografts . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of the surface integrin subunits CD11a , CD11b , and CD 18 on rat neutrophils isolated from peripheral blood was quantitated with flow cytometry . ^^^ The adhesive role of the integrin subunits CD11a , CD11b , and CD 18 was tested using specific neutralizing monoclonal antibodies . ^^^ RESULTS : Neutrophil CD11a , CD11b , and CD 18 surface integrin levels were 62 % ( n = 5 , P = 0 . 006 ) , 54 % ( n = 5 , P = 0 . 045 ) , and 38 % ( n = 5 , P = 0 . 009 ) greater in diabetic versus nondiabetic animals , respectively . ^^^ Pretreatment of leukocytes with either anti CD11b or anti CD 18 antibodies lowered the proportion of adherent diabetic neutrophils by 41 % ( n = 6 , P = 0 . 01 for each treatment ) , whereas anti CD11a antibodies had no significant effect ( n = 6 , P = 0 . 5 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The leukocyte integrin , lymphocyte function associated antigen 1 ( LFA 1 ) ( CD11a / CD18 ) , mediates cell adhesion and signaling in inflammatory and immune responses . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD11a is a subunit of LFA 1 , a cell surface molecule involved in T cell mediated immune responses . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To elucidate the mechanism of CAM related mediation of altered airway responsiveness in the atopic asthmatic state , the expressions and actions of intercellular adhesion molecule 1 ( ICAM 1 ) and its counterreceptor ligand lymphocyte function associated antigen 1 ( LFA 1 ; i . e . , CD11a / CD18 ) were examined in isolated rabbit airway smooth muscle ( ASM ) tissues and cultured human ASM cells passively sensitized with sera from atopic asthmatic patients or nonatopic nonasthmatic ( control ) subjects . ^^^ These proasthmatic changes in agonist responsiveness were ablated by pretreating the atopic sensitized tissues with a monoclonal blocking antibody ( MAb ) to either ICAM 1 or CD11a , whereas a MAb directed against the related beta ( 2 ) integrin Mac 1 had no effect . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We found that monoclonal antibodies against CD11a , CD11b , CD 18 , or LW ( ab ) block adhesion of transfectant L cells to immobilized ICAM 4 Fc protein and that the ICAM 4 / beta ( 2 ) integrin interaction was highly sensitive to the presence of the divalent cations Ca ( 2+ ) and Mg ( 2+ ) . ^^^ The red cell ICAM 4 / LW blood group glycoprotein , which belongs to the family of intercellular adhesion molecules ( ICAMs ) , has been reported to interact with CD11a / CD18 ( LFA 1 ) and CD11b / CD18 ( Mac 1 ) beta ( 2 ) integrins . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition , we analysed ( by flow cytometry ) whether this function correlated with modifications of the CD 2 , CD11a , CD11b and CD 18 molecules , which are involved in the adhesion of effector cells to the counter receptors ( CD 54 and CD 58 ) on osteosarcomas . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
INTRODUCTION : Leukocyte function associated antigen 1 ( LFA 1 , CD11a ) monoclonal antibody ( mAb ) affects many leukocyte functions without cell depletion . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Influence of beta ( 2 ) integrin adhesion molecule expression and pulmonary infection with Pasteurella haemolytica on cytokine gene expression in cattle . beta ( 2 ) Integrins are leukocyte adhesion molecules composed of alpha ( CD11a , b , c , or d ) and beta ( CD 18 ) subunit heterodimers . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Pre incubation of PMNL with monoclonal antibodies to CD11a and CD 18 that recognize alpha and beta chains of the LFA 1 integrin , a leukotoxin receptor on PMNL , inhibited the cytolysis , but not the release of granule components . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD 13 Ag and CD11a , CD11b , CD 18 molecule expression on peripheral blood mononuclear cells ( PBMC ) were studied as these cells ' adherent or transendothelial migration properties in three different multiple sclerosis ( MS ) patients groups ( total 38 ) : with clinically active MS ( acute exacerbation of MS and primary chronic progressive MS ( CP MS ) ) and with MS remission . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
While co stimulation through LFA 1 ( CD11a and CD 18 ) significantly reduced AICD in the CD 8 ( + ) CD 28 ( + ) subset , death was not prevented in CD 8 ( + ) CD 28 ( ) cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The CD11a / CD18 leukocyte integrin ( LFA 1 ; also known as alphaL / beta2 ) mediates leukocyte transendothelial migration during immune and inflammatory responses and participates in lymphoma metastasis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Additionally , the appearance of several activation ( CD 25 , CD 69 , HLA DR ) and adhesion ( CD11a , CD11b , CD11c , CD 18 , CD49b , CD49d , CD 54 ) receptors on CD 4 cells were analyzed . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition , the surface markers alpha 2 , alpha 3 , alpha 4 , CD11a , CD11b , CD 18 , CD 54 , and CD 8 found on lymphocytes and alpha 3 , alpha 4 , CD11a , CD 18 , and CD 8 surface markers found on granulocytes were also decreased in the patient population . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies against CD11a , CD 18 and CD 54 , but not CD11b , restored eosinophil suppression of T lymphocyte proliferation which was chymostatin resistant in coculture . ^^^ These cells also control interactions with lymphocyte between adhesion molecules , CD11a , CD 18 and CD54 . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
On the other hand , the beta 2 integrins CD11a , CD11b , CD11c and CD 18 were all expressed on MAC and DC . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Serial colonic sections ( 10 UC , 10 CD , and 10 controls ) were stained immunohistochemically for ICAM 1 , ICAM 2 , ICAM 3 , CD11a , CD11b , CD 18 , and PECAM 1 . ^^^ In conclusion , CD11b , CD 18 , and ICAM 2 seem to be important for PMN transepithelial migration in UC , whereas CD11a , CD11c , ICAM 1 , and ICAM 3 seem central in leukocyte locomotion and aggregation in CD . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Further , the changes of these markers and costimulatory molecules [ LFA 1 ( CD11a ) , ICAM 1 ( CD 54 ) , CD 40 and CD 40 ligand ( CD 154 ) ] were also examined in the responsive patients . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Both stressors led to an increased density of LFA 1 ( CD11a ) on mixed lymphocytes ( p values < . 01 ) , whereas CD11a density on monocytes and granulocytes remained unchanged . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We found that the expression of the integrin beta chain , CD 18 , was also maximized at 10 ( 8 ) M fMLP , along with only slight changes in the expression of integrin alpha chains ( CD11a , b , c ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We now extend our observations in 71 DLCL patients by analyzing malignant B cell expression of the following molecules important in T cell activation : ( a ) recognition molecules [ MHC 1 ( MAS and MCA ) and MHC 2 ( HLA DR , DP , DQ ) ] ; ( b ) CAMs [ leukocyte function antigen 1 ( CD11a and CD 18 ) and intracellular adhesion molecule 1 ( CD 54 ) ] ; and ( c ) CSMs [ B7 . 1 ( CD 80 ) and B7 . 2 ( CD 86 ) ] . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We have serially monitored the cell surface expression of integrins CD49d ( VLA 4 ) and CD11a ( LFA 1 ) on fresh T lymphocyte subpopulations from 5 MS patients monthly for 2 months prior to treatment and for 3 months on treatment with IFN beta1b . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Molecular and functional characterization of porcine LFA 1 using monoclonal antibodies to CD11a and CD 18 . ^^^ We describe in this report the production and characterization of monoclonal antibodies ( mAb ) to the swine homologues of CD11a and CD 18 antigens , and their use for phenotypic and functional analysis of porcine leukocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
When peripheral blood mononuclear cells ( PBMC ) obtained from healthy donors were cultured in the presence of culture supernatants of KC separated from the noninflamed gingivae ( Nor KC ) and cheek mucosae of patients with OLP ( OLP KC ) , the number of migrated PBMC across monolayered human umbilical vein endothelial cells ( HUVEC ) were increased to about 1 . 3 fold and 1 . 5 fold of the control level , respectively , with increases of the expression of CD11a , CD11b , CD 18 , and CD49d on PBMC and intracellular adhesion molecule 1 , vascular cell adhesion molecule 1 , and endothelial leukocyte adhesion molecule 1 on HUVEC . ^^^ The number of migrated PBMC was reduced to about 60 % of the control level by pretreatment of PBMC with anti CD11a or anti CD 18 MAb and reduced to about 70 % by pretreatment of HUVEC with anti CD 54 MAb . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In the present study , we used intravital microscopy of the cremaster muscle in CD11a gene targeted mice to examine the role of lymphocyte function antigen 1 ( LFA 1 , CD11a / CD18 ) in tumour necrosis factor alpha ( TNF alpha ) induced leucocyte rolling and firm adhesion in venules . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
End points were stimulated IL 6 levels and peripheral blood mononuclear cell ( PBMC ) CD11a ( LFA 1 ) expression and in vitro PBMC adhesion to human umbilical venous endothelial cells ( HUVEC ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Alveolar recruited monocytes showed a blood monocytic phenotype as assessed by cell surface expression of F4 / 80 , CD11a , CD11b , CD 18 , CD49d , and CD62L . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of adhesion molecules LFA 1 ( CD11a and ICAM 1 ( CD 54 ) on lymphocytes and chemokines IL 8 and MCP 1 concentrations in bronchoalveolar lavage of patients with asthma or chronic obstructive pulmonary disease ] . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In these subjects we determined , at baseline and after in vitro activation with 4 phorbol 12 myristate 13 acetate and N : formyl methionyl leucyl phenylalanine , the polymorphonuclear leukocyte membrane fluidity , obtained by labeling the cells with 1 [ 4 ( trimethylamino ) phenyl ] 6 phenyl 1 , 3 , 5 hexatriene , cytosolic Ca ( 2+ ) concentration , obtained by marking the cells with Fura 2 AM , and integrin pattern ( CD11a , CD11b , CD11c , and CD 18 ) , by using the indirect immunofluorescence with a flow cytometer . ^^^ At baseline there was no difference in membrane fluidity between normal subjects and hypertensives , whereas hypertensives showed an increase in cytosolic Ca ( 2+ ) content and an increase of the phenotypical expression of CD11a , CD11b , and CD 18 . ^^^ In normal subjects , after activation , we observed a significant increase of the expression of all adhesion molecules , whereas in hypertensives we found an increase of the expression of CD11b , CD11c , and CD 18 but also a decrease of CD11a . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
OBJECTIVE : The purpose of this study was to determine whether expressions of the cell adhesion molecules LFA 1 ( CD11a ) , VLA 4 ( CD49d ) , and L selectin ( CD62L ) on CD 34 ( + ) stem and progenitor cells in umbilical cord blood change during gestation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Extended studies demonstrated that : 1 ) ASM cells express mRNAs and proteins for the cell adhesion molecules ( CAMs ) / costimulatory molecules , CD 40 , CD40L , CD 80 , CD 86 , ICAM 1 ( CD 54 ) , and LFA 1 ( CD11a / CD18 ) ; 2 ) apart from LFA 1 , ASM cell surface expression of the latter molecules is up regulated in the presence of activated T cells ; and 3 ) pretreatment of ASM cells and tissues with mAbs directed either against CD11a or the combination of CD 40 and CD 86 completely abrogated both the activated T cell induced changes in expression of the above CAMs / costimulatory molecules in ASM cells and altered ASM tissue responsiveness . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Nuclear run on assays demonstrated that inhibiting DNA methylation increased transcription of CD11a but not CD 18 or beta actin mRNA . ^^^ Together , these results indicate that DNA methylation inhibitors can cause LFA 1 overexpression directly by demethylating the CD11a promoter . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
RESULTS : CD 20 , CD 22 , CD 24 , CD 40 , CD79a , CD79b , FMC 7 , CD11a , CD 18 , CD 44 were positive in the whole B cell population , whereas CD 10 , CD 86 , CD 103 , CD 154 and FasL were almost absent from the B lymphocyte population . 75 % were IgD positive . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We periodically drew blood from the dorsalis pedis vein and a brachial vein of 11 healthy test persons and 8 patients with stage 3 CVI during experimental venous hypertension in order to evaluate the expression pattern of leukocyte adhesion molecules involved in inflammation : LFA 1 ( CD11a ) , Mac 1 ( CD11b ) , p 150 , 95 ( CD11c ) , CD 18 , VLA 4 ( CD49d ) , and L selectin ( CD62L ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
All expressed high levels of CD11a ( LFA 1 ) , CD11b ( Mac 1 ) , and CD 54 antigens , with low levels of class 2 major histocompatibility complex . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We analyzed the phenotype of CB monocytes in the presence or absence of an inflammatory signal ( rIFN gamma ) and compared them to adult blood ( AB ) ; the expression of HLA DR and 17 different markers ( CD11a , CD11b , CD11c , CD 18 , CD 29 , CD 40 , CD 44 , CD49a , CD49d , CD49e , CD49f , CD 54 , CD 58 , CD62L , CD 80 , CD 86 and CD 102 ) was measured by flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
RESULTS : At 1 week of culture , cells expressed CD11a , CD 18 , CD 29 , CD49d , and CD49e . ^^^ At 14 weeks of culture , more mature CHMCs expressed CD11b , CD11c , CD 29 , CD49b , CD49c , CD49d , CD49e , CD 51 , CD 61 , and CD 54 and weakly expressed CD 18 and CD11a . ^^^ Compared with levels at week 1 , the levels of CD11a , CD 18 , CD49d , and CD49e at 4 weeks and beyond decreased during culture . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The effects of treatment with monoclonal antibodies against CD11a ( WT 1 ) and CD 18 ( WT 3 ) at a dose of 0 . 8 mg / kg on uterine blood flow and IUGR were investigated . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
On the other hand , CD11a , CD 18 , CD 31 , CD49d , or CD 54 was not markedly enhanced on the U 937 cells by culture with cytochalasin E , although the mean fluorescence intensities ( MFIs ) of CD11a , CD 18 , and CD 54 on U 937 was partially up regulated . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
FACScan analysis revealed that these tumor cells expressed high levels of intercellular adhesion molecule 1 ( ICAM 1 ) but did not express CD11a , CD11b , or CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD 18 and CD11a were evident in platelets from + / + , but not from CD 18 / mice , as seen by immunofluorescence or Western blots . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The effect of infection of sheep with the gastrointestinal nematode parasite Trichostrongylus colubriformis on expression of adhesion molecules CD11a , CD11b , CD11c , CD 18 , CD 44 , CD49d and CD62L by peripheral blood eosinophils was examined by flow cytometry . ^^^ In comparison with blood , the percentage of eosinophils expressing CD 18 increased and the percentage expressing CD62L decreased in exudates and the mean fluorescent intensity , an indicator of receptor number per cell , for CD11a and CD49d also decreased on exudate eosinophils . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We examined in 19 subjects with acute ischaemic stroke ( AIS ) the PMN integrin pattern ( CD11a , CD11b , CD11c , CD 18 ) , using indirect immunofluorescence and adopting a flow cytometer , at baseline and during activation , prolonged for 5 and 15 min , with 4 phorbol 12 myristate 13 acetate ( PMA ) . ^^^ After activation , we found in normals a constant and significant increase of all PMN adhesive molecules , while in AIS subjects , we found an increase in CD11b and CD 18 , a decrease in CD11a and no variation in CD11c . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Physiological concentrations of ICAM 1 ( 0 . 05 500 pM ) were separated from neutrophils by nitrocellulose filters , and cell migration was evaluated using the leading front technique . beta 2 integrins on neutrophils were blocked with antibodies to CD11a , CD11b , CD11c and CD 18 , and migration towards ICAM 1 was examined . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Fluorescence activated cell sorter analysis revealed downregulation of U 937 surface expression of CD11a , CD 18 , and VLA 4 after statin treatment . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In vitro activated gammadelta T cells showed dominant expression of LFA 1 ( CD11a ) , VLA alpha 4 ( CD49d ) , intermediate expression of VLA alpha 5 ( CD49e ) and L selectin ( CD62L ) , but low expression of CD44v6 and alphaEbeta 7 ( CD 103 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
By flow cytometry , we also measured the expression of leukocyte CD11a , CD11b , CD11c , CD 18 , CD 31 , CD49d , and CD62L ( L selectin ) in 13 patients . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
TNFalpha in both a dose and time dependent fashion induced expression of CD11a ( LFA 1 ) , CD 54 ( intercellular adhesion molecule 1 , ICAM 1 ) , CD 106 ( vascular cell adhesion molecule 1 , VCAM 1 ) , CD49d ( very late activating antigen 4 , VLA 4 ) , and / or MUC 1 on MM cell lines ; as well as CD 106 ( VCAM 1 ) and CD 54 ( ICAM 1 ) expression on BMSCs . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Flow cytometric analysis of membrane antigen density of neutrophils activated with bG CSF revealed an upregulation in the expression of CD11a ( > 114 % ) , CD11b ( > 148 % ) , CD11c ( > 87 % ) , and CD 18 ( > 109 % ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
IL 18 time and concentration dependently upregulated the expression of intercellular adhesion molecule 1 ( ICAM 1 ) in a monocyte population in human PBMC as determined by FACS analysis while the expression of CD11a , CD 18 , CD 29 , CD 44 , and CD62L in monocytes and that of ICAM 1 , CD11a , CD 18 , CD 29 , CD 44 , and CD62L in T cells was not influenced by IL 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Direct binding of ESM 1 to LFA 1 integrin was demonstrated by specific coimmunoprecipitation by CD11a and CD 18 mAbs . ^^^ Human endothelial cell specific molecule 1 binds directly to the integrin CD11a / CD18 ( LFA 1 ) and blocks binding to intercellular adhesion molecule 1 . ^^^ These results suggest that ESM 1 and ICAM 1 interact with LFA 1 on binding sites very close to but distinct from the 1 domain of CD11a . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
They expressed CD 4 , CD11a , CD11b , CD11c , CD 18 , CD 32 , CD 33 , CD45R0 , CD 48 , CD 50 , CD 54 , CD 58 , CD 64 , CD 86 , CD 102 , CD 116 , CD 123 , and HLA DR ; showed no expression of CD1a and CD 83 ; and weak expression of CD 16 , CD45RA , and CD 80 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD 18 ( A270V ) supports , at a diminished level , CD11b / CD18 ( Mac 1 , alphaMbeta 2 integrin ) and CD11c / CD18 ( p 150 , 95 , alphaXbeta 2 integrin ) expression and function but not CD11a / CD18 ( LFA 1 , alphaLbeta 2 integrin ) expression . ^^^ Conversely , CD 18 ( A341P ) supports a limited level of expression and function of CD11a / CD18 , but not of the other two CD11 / CD18 antigens . ^^^ CD 18 ( C590R ) and CD 18 ( R593C ) show a decreasing capacity to associate with the CD11a , CD11c and CD11b subunits . ^^^ CD 18 ( A270V ) supports , at a diminished level , CD11b / CD18 ( Mac 1 , alphaMbeta 2 integrin ) and CD11c / CD18 ( p 150 , 95 , alphaXbeta 2 integrin ) expression and function but not CD11a / CD18 ( LFA 1 , alphaLbeta 2 integrin ) expression . ^^^ Transfectants expressing the CD11a / CD18 with the C590R and R593C mutations are more adhesive than transfectants expressing wild type LFA 1 , and express the reporter epitope of the monoclonal antibody 24 constitutively . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Overexpression of protein kinase C zeta ( PKC zeta ) in the leukemic myeloid cell line U 937 ( U 937 PKC zeta cells ) , previously shown to induce leukemic cell differentiation , resulted in nearly complete downregulation of leukocyte integrins CD11a , CD11b , CD11d , and CD 18 , but not CD11c from the cell surface . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Comparing to control group adhesion molecules CD11b , CD 18 , CD 31 , CD49d , CD 54 and CD62L were increased on the surface of patient neutrophils whereas no differences were observed in the expression of CD11a abd CD 15 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Binding of LFA 1 ( CD11a ) to intercellular adhesion molecule 3 ( ICAM 3 ; CD 50 ) and ICAM 2 ( CD 102 ) triggers transmigration of human immunodeficiency virus type 1 infected monocytes through mucosal epithelial cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
AIMS : The present study analyzed exudation , cell migration , and CD11a and CD 18 subset cells of both local and systemic responses induced by fecal peritonitis in mice . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Incubation of PMNs with anti CD 16 prevented the up regulation of beta ( 2 ) integrins , particularly CD11b , which is the alpha chain of complement receptor type 3 , but also CD 18 , which is its beta chain , as well as CD11a and CD11c . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expressions of L selectin ( 93 . 0 + / 5 . 7 % , p < 0 . 05 vs arterial ) , CD11a ( 98 . 8 + / 3 . 8 % , p=0 . 06 ) , CD 18 ( 96 . 9 + / 4 . 0 % , p < 0 . 05 vs arterial ) , and ICAM 1 ( 89 . 1 + / 7 . 7 % , p < 0 . 05 ) on polymorphonuclear neutrophils ( PMN ) , and arteriovenous leukocyte counts ( arterial : 103 . 5 + / 5 . 4 % , venous : 91 . 1 + / 3 . 3 % , p < 0 . 05 ) decreased . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
BACKGROUND : Anti CD11a ( hu 1124 ) is a humanized monoclonal antibody directed against the CD11a subunit of LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Using an array of function blocking monoclonal antibodies ( mAb ) ( anti CD11a , CD11b , CD 18 , CD49d , CD 54 , and CD 106 ) , we characterized the adhesive interactions underlying the transendothelial and transepithelial leukocyte traffic in intact animals . ^^^ Comigrating neutrophils were found to primarily utilize CD11b , CD 18 , and CD 54 , but not CD49d , CD 106 , or , surprisingly , CD11a . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
OBJECTIVE : To explore the protein expression level of the lymphocyte function related antigen CD11a , CD 18 , CD 54 of breast cancer patients ' blood , cancer tissue and drainage lymph node , and the effect of chemotherapy as well as Yiqi Yangxue Granule on its expression level . ^^^ METHODS : The immunohistochemical assay and flow cytometry were used to determine the change of the protein expression level of CD11a , CD 18 , CD 54 on the lymphocyte of blood , cancer tissue and lymph node between before and after chemotherapy and chemotherapy plus Yiqi Yangxue Granule in 72 patients suffering from breast cancer . ^^^ RESULTS : In breast cancer patients , the level of CD 54 was increased more obviously than that of control group , the CD11a , CD 18 , CD 54 of lymphocytes in cancer tissue increased remarkably , while the CD 54 expression positive rate reached 100 % , the expression level of CD11a , CD 18 , CD 54 which increased significantly in negative lymph node obviously higher than that of positive lymph node . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Superoxide anion production by isolated peripheral blood granulocytes , their phagocytosis , and expression of cell adhesion molecules such as CD11a , CD11b , and CD 18 on granulocytes were measured by flow cytometry . ^^^ The levels of CD11a , CD11b and CD 18 expression on peripheral blood granulocytes and superoxide anion production by granulocytes were significantly suppressed by chemotherapy without CSF support . ^^^ The levels of CD11a and CD 18 expression on granulocytes were significantly enhanced by administration of M CSF . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In this study we analysed blood samples taken from the dorsalis pedis vein and a brachial vein of 11 healthy test persons and 8 patients with venous leg ulcer under experimental venous hypertension in order to examine changes in the expression of leukocyte adhesion molecules ( LFA 1 ( CD11a ) , Mac 1 ( CD11b ) , p 150 , 95 ( CD11c ) , CD 18 , VLA 4 ( CD49d ) and L selectin ( CD62L ) ) which are involved in the adhesion steps of leukocytes to endothelial cells for transmigration into tissues . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Following one week of diabetes , neutrophil CD11a , CD11b , and CD 18 expression was increased significantly , as were retinal ICAM 1 levels . ^^^ High dose aspirin also reduced the expression of CD11a , CD11b , and CD 18 , whereas meloxicam and etanercept did not . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
METHODS : Allogeneic skin transplantation was performed using BALB / c mice as donors and C57BL / 6J wild type or LFA 1 deficient ( CD11a ( / ) ) mice as recipients . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Although neutrophil CD11a , CD11b , and CD 18 levels were increased in 1 week diabetic animals , VEGF TrapA ( 40 ) did not alter the expression of these integrin adhesion molecules . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
METHODS : Rats were assigned to one of six groups including sham operation , intestinal IR ( 60 / 120 min ) and IR plus treatment with one of the following monoclonal antibodies against CD11a , CD11b , CD 18 , and ICAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
OBJECTIVE : The aim of this study was to analyze mutations in DNA from patients with leukocyte adhesion deficiency ( LAD ) , an immunodeficiency caused by absence of the beta ( 2 ) subunit ( CD 18 ) of the leukocyte integrins LFA 1 ( CD11a / CD18 ) , Mac 1 ( CD11b / CD18 ) , p 150 , 95 ( CD11c / CD18 ) , and CR 4 ( CD11d / CD18 ) . ^^^ We cotransfected the two mutant CD 18 proteins with normal CD11a , b , or c in COS cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Compared to healthy controls , there was decreased expression of CD11a , CD11b , CD 18 , CD49b , CD49c , CD49d , CD 54 , and CD 8 in patients ' lymphocyte populations and CD11a , CD 18 , CD49c , CD49d , and CD 8 in patients ' granulocyte populations . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Antibodies to CD 31 , CD 54 , CD62E , and CD62P on EC or CD11a , CD 18 , and CD 162 on NK cells had only minor effects on rolling adhesion . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
BACKGROUND : Leukocyte function associated antigen 1 ( LFA 1 ) , consisting of CD11a and CD 18 subunits , plays an important role in T cell activation and leukocyte extravasation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of adhesion molecules ( CD11a , CD11b , CD 18 , CD49d , CD 54 , CD62L ) on peripheral blood mononuclear cells ( PBMCs ) of asthmatics and the expression of E and P selectins , ICAM 1 , VCAM 1 on cultured human umbilical vein endothelial cells ( HUVEC ) after stimulation with PBMCs from CDAs before and after 3 and 6 months of SeS were assessed by standard monoclonal antibodies and analyzed by flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Up regulation of CD11a ( LFA 1 ) expression on peripheral CD4+ T cells in primary biliary cirrhosis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Blocking monoclonal antibodies were used against the platelet and neutrophil surface receptors glycoprotein complex IIb / IIla , P selectin , ICAM 2 , CD11a , CD11b , and CD 18 . ^^^ The difference between the Pi of cells suspended in SPPP or NPPP ( deltaPi SPPP NPPP ) in the presence of monoclonal antibodies anti CD 41 , anti CD62P , abciximab , anti CD11a , anti CD11b , and anti CD 18 was significantly less than the APi SPPP NPPP of cell suspensions without the addition of these monoclonal antibodies ( P < 0 . 01 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The beta 2 integrins leukocyte function antigen 1 ( LFA 1 , CD11a ) and macrophage antigen 1 ( Mac 1 , CD11b ) have been reported to play a role in the attachment of CD 34 ( + ) cells to stromal cells in the bone marrow . ^^^ Enhancement of mobilization was not observed in LFA 1 deficient ( CD11a ) mice , indicating that activated cells expressing LFA 1 mediate the synergistic effect , rather than LFA 1 mediated adhesion . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Resveratrol ( 10 microM ) enhanced the expression of adhesion molecules ( CD11a , CD11b , CD 18 , CD 54 ) in each of the cell lines except for Kasumi 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression patterns of CD11a , the alpha subunit of LFA 1 ; CD 18 , the beta subunit of LFA 1 ; and alpha d , a novel alpha subunit of the beta 2 integrin family were assessed for each of these lymphocyte subsets . ^^^ We aimed , therefore , to determine whether there was a corresponding alteration in the expression of CD11a / CD18 ( LFA 1 ) , the primary lymphocyte beta 2 integrin , among the principal subsets of lamina propria lymphocytes ( LPLs ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
After EB challenge , levels of 10 of 17 markers ( CD11a , CD11b , CD 14 , CD 18 , CD 23 , CD 32 , CD 63 , CD 64 , HLA class 1 , and HLA DR ) were significantly increased ( by 33 234 % , P < 0 . 05 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The aim of this study was to evaluate the association of the expression of the adhesion molecules CD11a , CD11b , CD 18 , CD 54 , CD49d , and CD 62 L in white blood cells and levels of soluble adhesion molecules ICAM 1 and L selectin in serum with occupational exposure to styrene . ^^^ Expression of the adhesion receptor antigens CD11a on lymphocytes , CD11b on monocytes , and CD 18 on granulocytes were unaffected . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The autoimmunity is due in part to the heterodimeric beta ( 2 ) integrin lymphocyte function associated antigen 1 ( LFA 1 ) ( CD11a / CD18 ) overexpression , and T lymphocytes from lupus patients hypomethylate the same CD11a promoter sequences , overexpress LFA 1 and demonstrate the same autoreactivity . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Flow cytometric analysis revealed that incubation with RLPs increased expression levels of CD11a , CD 18 , and CD49d in U 937 cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Analysis of 10 surface molecules , CD11a , CD 18 , CD 29 , CD49d , CD49e , CXCR 4 , CD62L , CD 31 , CD 43 , and CD 44 over a 5 day culture period showed that their expression levels were either maintained or up regulated on CD 34 ( + ) cells and the primitive Thy 1 ( + ) subset . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The leukocyte function associated antigen 1 molecule ( LFA 1 ) , a heterodimer of CD11a ( alphaL ) and CD 18 ( beta 2 ) integrin subunits , is an attractive therapeutic target because it plays an important role in key steps of inflammation and tissue rejection . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The hypomethylation effects are due , in part , to overexpression of lymphocyte function associated antigen 1 ( LFA 1 ) ( CD11a / CD18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD 18 was expressed as a mature and an immaturely glycosylated form in Jurkat T cell lines , and predominantly the immature form , not associated with CD11a , was found in Lck deficient cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Lkt binds to beta ( 2 ) integrins on the surface of bovine leukocytes . beta ( 2 ) integrins have a common beta subunit , CD 18 , that associates with three distinct alpha chains , CD11a , CD11b , and CD11c , to give rise to three different beta ( 2 ) integrins , CD11a / CD18 ( LFA 1 ) , CD11b / CD18 ( Mac 1 ) , and CD11c / CD18 ( CR 4 ) , respectively . ^^^ Immunoprecipitation of cell surface proteins of 2B2 with monoclonal antibodies specific for bovine CD 18 or murine CD11a suggested that bovine CD 18 was expressed on the cell surface of 2B2 as a heterodimer with murine CD11a . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Dual label confocal microscopy revealed that LFA 1 ( CD 18 and CD11a ) , but not CXCR 4 , colocalized with clustered CCR 6 in the presence of immobilized CCL 20 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We investigated the role of the leukocyte function antigen 1 and its two subunits CD11a and CD 18 in the lysis of bladder tumor cells by both effector cell populations . ^^^ We used flow cytometry to measure CD11a and CD 18 expression on BAK and LAK cells . ^^^ BAK and LAK cells expressed more CD11a and CD 18 on their surfaces than unstimulated peripheral blood mononuclear cells . ^^^ Cytotoxicity of both BAK and LAK cells was inhibited by a combination of anti CD11a and CD 18 monoclonal antibodies . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Peripheral blood was collected at the day prior to surgery and the morning of postoperative days 1 , 2 , 5 , and 7 for determination of the expression of leukocyte CD11a , CD 18 , CD11a / CD18 , CD11b , CD11b / CD18 ( immunofluorescent flow cytometry ) and the plasma soluble intercellular adhesion molecule 1 ( sICAM 1 ) , soluble E selectin ( sE selectin ) ( enzyme linked immunoabsorbent assay ) . ^^^ CPB caused a sustained increase in the leukocyte CD11a , CD 18 , CD11a / CD18 , CD11b / CD18 expression and the plasma sICAM 1 , sE selectin levels in patients ( P < 0 . 05 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Fluorescence activated cell sorting analyses showed that neither tumors nor ascitic cells grown in SCID mice expressed leukocyte function associated antigen ( LFA ) 1alpha ( CD11a ) , LFA 1lbeta ( CD 18 ) , LFA 2 ( CD 2 ) , LFA 3 ( CD 58 ) , intercellular adhesion molecule ( ICAM ) 1 ( CD 54 ) , ICAM 2 ( CD 102 ) , ICAM 3 ( CD 50 ) , or leukocyte endothelial adhesion molecule ( LECAM ) 1 ( CD62L ) , suggesting that these cytoadhesion molecules are not involved in tumor formation of RM P 1 cells in vivo . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The PMN adhesion molecules ( CD11a , CD11b , CD11c , CD 18 ) were evaluated using indirect immunofluorescence and a flow cytometer , at baseline and after in vitro activation with 4 phorbol 12 myristate 13 acetate ( PMA ) and N formyl methionyl leucyl phenyl alanine ( fMLP ) . ^^^ At baseline , in diabetic subjects the phenotypical expression of CD11a and CD11b was significantly reduced and CD11c was increased , whereas CD 18 was unchanged in comparison with normals . ^^^ Considering type 1 and 2 diabetic subjects separately , CD11a was reduced and CD11c was increased in both subgroups , CD11b was decreased only in type 1 diabetics and CD 18 , decreased in type 1 , was increased in type 2 subjects . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD 154 and LFA 1 ( CD11a ) represent conceptually distinct pathways of receptor / ligand interactions ( costimulation and adhesion / homing , respectively ) that have been effectively targeted to induce long term allograft acceptance and tolerance . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Transgenic mice have been generated that carry a CD 45 minigene under control of the human leukocyte function associated antigen ( LFA 1 , CD11a ) promoter . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
METHODS : In this comparative study , serum immunoglobulins , IgG subclasses , secretory IgA , serum complement components , lymphocyte subsets and CD11a , CD 18 , CD 54 molecules on lymphocytes were determined in 44 hospitalized patients of chronic HBV infection and 20 cases of healthy control subjects . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Likewise , none of the neutralizing mAbs against CD11a , CD 18 , CD 44 , CD49e , or CD 54 showed significant effects . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The adhesive mechanisms underlying I / R induced leukocyte rolling and adhesion were investigated using monoclonal antibodies against L , E and P selectin , and CD11a gene targeted mice were used to examine the role of lymphocyte function antigen 1 ( LFA 1 , CD11a / CD18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In this study , we examined the role of the adhesion receptor LFA 1 in ConA induced acute hepatic damage using LFA 1 ( / ) ( CD11a ) mice . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Cell surface expression of CD 18 , CD11a , CD11b , CD11c , CD 50 , and CD 54 was not affected by Na ( 2 ) SO ( 3 ) treatment . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Adhesion of dendritic cells derived from CD34+ progenitors to resting human dermal microvascular endothelial cells is down regulated upon maturation and partially depends on CD11a CD 18 , CD11b CD 18 and CD 36 . ^^^ Mature DC lacked expression of CD 31 , CD 36 , CD45RA and CLA , and expressed lower levels of CD11a , CD11b and CD49d as compared with precursors tested on day 5 . mAb against CD 18 , CD11a , CD11b , and CD 36 markedly inhibited DC binding , whereas anti CLA , anti DC SIGN , anti CD 29 and anti CD 49 mAb did not . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of the adhesion molecules , ICAM 1 , VCAM 1 , NCAM , CD 44 , CD49d ( VLA 4 , alpha chain ) , and CD11a ( LFA 1 , alpha chain ) on mouse oocytes , and pre and peri implantation stage embryos was examined by quantitative indirect immunofluorescence microscopy . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The increased expression of CD11a ( LFA 1 ) and CD 58 ( LFA 3 ) was noted on some cancer cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The cells were exposed to 1 nm FMLP , 5 pm free ICAM 1 , or antibodies binding ICAM 1 or the beta 2 integrins CD11a , CD11b , CD11c and CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
As evidenced by flow cytometry , ATRA ( at 1 microM ) clearly and donor independently suppressed the expression of all integrin chains investigated ( CD11a , CD11b , CD11c , and CD 18 ) , most strikingly of CD11a . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD11a , CD11b , and CD 18 expression on lymphocytes and PMN were also measured by flow cytometory . ^^^ RESULTS : CD11a and CD 18 expression levels on PMN and lymphocytes of PIH patients were significantly higher than those of normal pregnant women ( p < 0 . 05 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Flow cytometric analysis of paclitaxel or vinblastine treated P 815 cells revealed reduced cell surface expression of the adhesion molecules LFA 1 ( CD11a / CD18 ) and ICAM 1 ( CD 54 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Immunofluorescence reactions were carried out on cells , to study the distribution of activation ( HLA DR , CD 25 , CD 69 ) and adhesion ( CD11a , CD 18 , CD 54 ) molecules ; the flow cytometry technique was used to analyse cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Efalizumab ( anti CD11a , Raptiva ; Genentech , Inc . ) is a mAb that targets the T cell adhesion molecule , leukocyte function associated antigen 1 ( LFA 1 ) . ^^^ By binding to CD11a the alpha subunit of LFA 1 LFA 1 is prevented from binding with its ligand , intercellular adhesion molecule 1 ( ICAM 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We evaluated the expression of some PMN integrins ( CD11a , CD11b , CD11c , CD 18 ) , using flow cytofluorimetry , at baseline and after in vitro activation with 4 phorbol 12 myristate 13 acetate . ^^^ Type 2 diabetic subjects with MVC showed , compared to normals , an increase of CD11a and CD 18 and a decrease of CD11b and CD11c . ^^^ In type 2 diabetic patients with MVC the basal upregulation of CD11a and CD 18 may be related to the PMN spontaneous activation , while the behavior of CD11b may depend on its self consumption . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Typically , mature cells express lower densities of L selectin ( CD62L ) , the homing receptor for secondary lymphoid organs , and higher densities of LFA 1 ( CD11a ) , the molecule associated with trafficking to non lymphoid reservoir sites . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Using the pre procedural expression levels , patients with restenosis could be predicted by discriminant analysis with CD11a , CD11b , and CD 18 ( average recognition index = 95 . 5 % ) . ^^^ Moreover , CD11a , CD11b , and CD 18 may be helpful as indicators for the progression of CAD . . ^^^ Surface expression of leukocyte adhesion molecules Mac 1 ( CD11b / CD18 ) , LFA 1 ( CD11a / CD18 ) , L Selectin ( CD62L ) , ICAM 1 ( CD 54 ) , and MHC 2 ( HLA DR ) were assessed by flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
METHODS : Trace cytotoxicity test plates were utilized in the detection of CD 3 , CD 4 , CD 8 , CD11a , CD11b , CD 18 and CD 54 on lymphocytes by APAAP immunocytochemical staining . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LFA 1 , an adhesion molecule that also participates in the co stimulatory pathway , has also been targeted with a mAb that binds to the CD11a chain of LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Analysis with Kruskal Wallis test showed no statistical significant differences in the expression of CD 54 , CD11a , CD11b and CD 18 in three groups examined . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Small molecule LFA 1 antagonists compete with an anti LFA 1 monoclonal antibody for binding to the CD11a 1 domain : development of a flow cytometry based receptor occupancy assay . ^^^ The beta ( 2 ) integrin LFA 1 ( CD11a / CD18 ) is a leukocyte specific adhesion molecule that mediates leukocyte extravasation , antigen presentation , and T cell mediated cytolysis through its interaction with its counter receptors , ICAM 1 , ICAM 2 , and ICAM 3 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression levels of adhesion molecules ( CD 2 , CD11a , CD 18 , DNAX accessory molecule 1 ) , CD 16 , and CD 57 for CD56dim NK cells in CB were significantly lower than those in PB , and approximately one third of CB CD56dim NK cells were capable of forming conjugates with K 562 cells , compared with PB CD56dim NK cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Ab to the LFA 1 subunits CD11a and CD 18 blocked lysis by the NK cells , indicating that the new LFA 1 correlated with , and was essential for , the cytotoxic function of the in vitro generated cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The CD11a / CD18 ( leukocyte function associated antigen 1 [ LFA 1 ] ) integrin mediates critical leukocyte adhesive interactions during immune and inflammatory responses . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast , in both the baboon and human studies , other neutrophil surface antigens were only slightly decreased ( CD11a ) or increased ( CD11b , CD 18 , CD 35 , CD66b , and CD 63 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In the present study , we have investigated the effects of blocking monoclonal antibodies ( mAbs ) directed against CD49d ( alpha ( 4 ) integrin ) , CD 18 ( beta ( 2 ) integrin ) and the alpha sub units of beta ( 2 ) integrin CD11a ( LFA 1 integrin ) and CD11b ( Mac 1 integrin ) , on antigen ( Ag ) induced acute bronchoconstriction and cellular recruitment in allergic rabbits in vivo . ^^^ Furthermore , eosinophil recruitment and activation appears to be mediated by a combination of VLA 4 ( CD49d / CD29 ) and LFA 1 ( CD18 / CD11a ) . ^^^ However in contrast , lymphocyte recruitment appears to be mediated by a combination of LFA 1 ( CD18 / CD11a ) and Mac 1 ( CD18 / CD11b ) . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of CD 18 and CD11a , b , c on bovine monocytes and PMN were assessed in 8 Friesian Holstein cows by flow cytometry from 2 wk before calving to 5 wk after calving . ^^^ Compared with PMN , monocytes exhibited an expression level that was similar for CD 18 , higher for CD11a and CD11c , but lower for CD11b . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
BACKGROUND : Efalizumab is a humanized IgG ( 1 ) mAb against the lymphocyte function antigen 1 ( LFA 1 ) alpha chain , CD11a . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
OBJECTIVE : To compare the expression of cell adhesion molecules ( CAMs ) among VLA 4 ( CD 49 d ) , VLA 5 ( CD49e ) , LFA 1 ( CD11a ) , L selectin ( CD62L ) , and PECAM 1 ( CD 31 ) which are more related to the homing of hematopoietic stem and progenitor cells ( HSPC ) on the ex vivo expanded CD34+ subset with that of fresh isolated AC133+ cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Exposure of 1 10 10 ( 6 ) cells / ml of KG1a cells to 100 ng / ml PF 4 the increased total adherence of KG1a cells was mediated by PECAM 1 ( CD 31 ) , CD 44 , LFA 1 ( CD11a ) and Mac 1 ( CD11b ) but not by P selectin ( CD62P ) and E selectin ( CD62E ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Our results give diagnostic power to only three antigens , HLA DR , CD11a and CD 18 , all of which are characteristically expressed at low levels by APL cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In each case , this was accompanied by a significant reduction in the percentage of cells expressing the differentiation markers CD11a , CD11b , and CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
These cells were also ICAM 1 ( CD 54 ) and LFA 1 ( CD11a ) positive . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
OBJECTIVE : The aim of this study was to investigate the expression of intercellular adhesion molecule 1 ( ICAM 1or CD 54 ) and the alpha subunits of its ligands ' lymphocyte function associated antigen 1 ( LFA 1 ) ( alphaL subunit or CD11a ) and Mac 1 ( alphaM subunit or CD11b ) on peripheral blood leucocytes in infants with cow ' s milk allergy ( CMA ) and in healthy controls . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
BACKGROUND : The purpose of the study was to evaluate the effects of cyclosporine ( CsA ) , FK 506 and mycophenolate mofetil ( MMF ) on graft infiltrating leukocytes ( CD 4 , CD 8 , CD11a , CD 18 ) after cardiac transplantation in rats . ^^^ Immunohistochemistry was performed using monoclonal antibodies ( MAb ) against CD 4 , CD 8 , CD11a and CD 18 . ^^^ RESULTS : CsA and FK 506 reduced the presence graft infiltrating leukocytes ( CD 4 , CD 8 , CD11a , CD 18 ) in the PVS of intra and epicardial arteries when compared with control animals . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
An immunophenotype analysis of the plasma cells showed positivity of cytoplasmic IgM , 10 , CD 5 , CD 38 , CD11a ( LFA 1 ) , CD 44 ( HCAM ) , CD49d ( VLA 4 ) and CD 54 ( ICAM 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Using flow cytometry analysis , the co addition of Fe citrate significantly suppressed CD 18 ( beta 2 integrin ) and CD 54 ( ICAM 1 ) but not CD11a ( alpha integrin ) expression on Con A stimulated monocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Efalizumab , a humanized monoclonal antibody , binds to the alpha subunit ( CD11a ) of LFA 1 and inhibits the activation of T cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Northern and Western blotting analyses showed that TNF alpha enhanced the expression of CD11a in the cells at both the mRNA and protein levels but did not do so for CD 18 expression . ^^^ Furthermore , the results of an assay of caspase 3 intracellular activity ( PhiPhiLuxG1D2 ) showed that Ltx induced caspase 3 activation was completely neutralized by CD 18 antibody treatment , although significant neutralization was also observed with anti CD11a antibody . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Along with the bovine CD 18 encoding cDNA , which is available for a long time , the sequence data provided here will allow the successful expression of bovine CD11a , thus giving the first opportunity to express the Bos taurus beta ( 2 ) integrin CD11a / CD18 ( LFA 1 , alpha ( L ) beta ( 2 ) ) in vitro as a tool to examine the specificities of inflammation in the bovine species . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The recognition of equine lymphocyte antigens by monoclonal antibodies ( mAbs ) directed against human CD11a , CD 18 , CD 21 , CD 23 , CD 29 and DR , as well as mouse CD 23 was studied by flow cytometry . ^^^ Unlike anti CD11a , CD 21 , CD 23 and DR mAbs , anti CD 18 and CD 29 mAbs labelled the same percentage of horse peripheral blood lymphocytes ( PBL ) as human PBL . ^^^ The molecular targets of anti CD11a , CD 18 and CD 29 mAbs were confirmed by immunoprecipitation of the membrane proteins . ^^^ Our results suggest that anti CD 18 , CD 29 and DR mAbs recognise similarly expressed molecular homologues on equine cells , but that anti CD11a , CD 21 and CD 23 mAbs recognise either different molecules or homologues that are expressed at different levels on horse cells . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In 27 subjects with VAD we examined , at baseline and after in vitro activation with 4 phorbol 12 myristate 13 acetate ( PMA ) , the PMN integrin pattern ( CD11a , CD11b , CD11c , CD 18 ) using indirect immunofluorescence and a flow cytometer . ^^^ At baseline VAD subjects showed an increase of CD11a and CD 18 and a decrease of Cd11b and Cd11c as compared to normal subjects . ^^^ After activation , in normal subjects , we found an increase in the expression of all integrins , while in VAD subjects we observed an increase of CD11b and Cd11c and a decrease of Cd11a and CD 18 . ^^^ In VAD subjects , at baseline , the upregulation of Cd11a and CD 18 may reflect PMN in vivo activation ; after in vitro activation , the decrease of CD11a may be related to the lack of cytoplasmic deposits of this molecule , while CD 18 might be internalized . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
METHODS AND RESULTS : The expression of leukocyte ( ie , neutrophil , monocyte and lymphocyte ) surface CD11a , CD 18 , intracellular adhesion molecule 1 ( ICAM 1 ) , very late antigen 4 alpha ( VLA 4 alpha ) and L selectin was investigated by flow cytometry in 20 patients who were initially diagnosed with CAD ( CAD group ) , 15 patients with coronary re stenosed vessels ( RESTE group ) , 20 undergoing HD ( HD group ) and 20 without CAD ( CONT group ) . ^^^ On the other hand , there were no significant differences in the expression of CD11a , CD 18 , L selectin or VLA 4 alpha between the HD group and CONT group , but monocyte L selectin was increased in the CAD group compared with the CONT group . ^^^ CONCLUSIONS : Because CD11a and CD 18 are expressed on the cell surface as a heterodimer and ICAM 1 is a ligand for CD11a / CD18 , this increased expression of CD11a and ICAM 1 may affect the development of initial atherosclerotic coronary stenosis , but not re stenosis . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The following phenotypic and functional parameters of the monocyte population were studied by flow cytometry : surface molecules expression ( CD 18 , CD11a , CD11b , CD 14 , CD 15 , CD 45 , HLA DR , and Toll like receptor [ TLR ] 4 ) , myeloperoxidase ( MPO ) content , and intracellular cytokine production ( tumor necrosis factor [ TNF ] alpha , interleukin [ IL ] 1beta , IL 6 , and IL 8 ) . ^^^ RESULTS : Cardiac surgery with CPB induced down modulation of surface molecules expression on peripheral monocytes , especially at 24 h after CPB , for CD 18 , CD11a , and CD11b ( P < 0 . 003 ) and for the CD 15 adhesive cluster ( P = 0 . 0028 ) and HLA DR ( P < 0 . 001 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Most of the DCs express immunocytochemically detectable antigens like : S 100 , CD1a , CD 40 receptor , adhesion molecules ( ICAM 1 or CD 54 , LFA 1 and LFA 3 ) , integrins ( CD11a , CD11c and CD 18 ) , CD 45 , CD 54 , co stimulatory molecules ( B 7 1 or CD 80 , B 7 2 or CD 86 ) , F 418 , MHC class 1 and 2 and DEC 205 , multilectin receptor , immunostimulatory cytokine ( IL 12 ) and , of course , Fc and complement receptors . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
DESIGN : This study utilized quantitative flow cytometry to determine whether the expression of surface adhesion molecules : CD 18 , CD11a , CD11b , and CD11c on cord blood neutrophils using mean channel fluorescence values ( MCF ) . ^^^ RESULTS : MCF values were significantly higher in infants born to pre eclamptic women vs controls : CD 18 ( 432 . 0+ / 236 . 3 vs 230 . 5+ / 97 . 9 ; p=0 . 002 ) , CD11a ( 552 . 9+ / 272 . 4 vs 326 . 9+ / 268 . 6 ; p=0 . 003 ) , CD11b ( 937 . 2+ / 521 . 9 vs 576 . 6+ / 352 . 9 ; p=0 . 025 ) , and CD11c ( 228 . 5+ / 130 . 3 vs 133 . 0+ / 77 . 1 ; p=0 . 006 ) , respectively . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies directed against CD 18 , CD11a , CD11b , CD11c , CD 21 , CD 3 , CD 4 , CD 8 and Major Histocompatibility Complex class 1 and 2 ( MHC 1 and MHC 2 ) were also employed . ^^^ Most of the infiltrating cells were positive for CD 18 and CD11a . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We measured the number of leukocytes and enzymes and the expression levels of CD11a , CD 18 , very late after activation antigen 4 alpha , intracellular adhesion molecule 1 ( ICAM 1 ) and L selectin by flow cytometry before and after coronary intervention , and at 6 , 12 , 18 , 48 and 72 hours of MI in 5 patients ( AMI group ) . ^^^ In the AMI group the expression of monocyte CD11a was significantly increased after 6 hours , and CD 18 and ICAM 1 expression were also significantly increased after 12 hours , whereas that of monocyte L selectin was increased after 72 hours . ^^^ In conclusion , since CD11a and CD 18 are expressed on the cell surface as a heterodimer and ICAM 1 is a ligand for CD11a / CD18 , their increased expression may contribute to their adhesion to endothelium in ischemic regions and may lead to the formation of microaggregates . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
An antibody to CD11b but not CD11a blocked migration to an extent similar as with anti CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of adhesion molecules CD11a , CD11b , and CD 18 on granulocytes decreased directly after the LCP treatment . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Antibodies against L selectin , but not against CD11a , CD11b , or CD 18 , reduced epsilon at 100 s ( 1 ) by > 85 % . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The defect in T cell proliferation with SEA was more severe in splenocytes from mice deficient in CD 18 , CD11b , or CD11d than in CD11a deficient splenocytes , with a normal response in CD11c deficient splenocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Directly fluorescence conjugated antibodies that were directed against adhesion molecules ( LFA 1 ( CD11a ) , HCAM ( CD 44 ) , VLA 2 ( CD49b ) , ICAM 1 ( CD 54 ) , NCAM ( CD 56 ) , LECAM 1 ( CD62L ) and CD 86 ) were used . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
When beta 2 ( CD 18 ) integrin or lymphocyte function antigen ( LFA ) 1 ( CD11a ) plus Mac 1 ( CD11b ) were blocked by mAb ( intact or Fab ' ) , the proportion of migrated PMN ( but not of non migrated PMN ) with active caspases was significantly increased ( 2 4 fold ) and this was associated with accelerated PMN apoptosis and death . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We present a review of the literature concerning treatment of psoriasis with humanized monoclonal antibody ( hu 1124 , efaluzimab , Xanelin ) against the CD11a component of lymphocyte function associated antigen 1 ( LFA 1 ) . ^^^ Efaluzimab inhibits the interaction of CD11a ( LFA 1 ) with various ICAM molecules . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In the present work we have investigated , by flow cytometric techniques , the expression of the two major integrins CD11a ( LFA 1 ) and CD49d ( VLA 4 ) that are the homing receptor cognate for ICAM 1 and VCAM 1 on human cord blood CD 34 hematopoietic progenitor and stem cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Both components of LFA 1 , CD11a and CD 18 , were downregulated during treatment , and surprisingly the integrins CD11b and beta 7 were similarly reduced . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD 18 , CD11a , CD11b , and CD 63 membranal levels were assayed by flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
RESULTS : In a test group of 58 APL patients , the most predictive immune profile was HLA DR ( low ) , CD11a ( low ) ( alpha ( L ) subunit of the leukocyte integrin LFA 1 ) , CD 18 ( low ) ( beta ( 2 ) subunit of LFA 1 ) . ^^^ HLA DR ( low ) , CD11a ( low ) , CD 18 ( low ) is a reliable surrogate antigen expression profile for PML / RAR alpha ( pos ) APL , irrespective of morphology and transcript isoform . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of adhesion receptors CD11a , CD11b , CD 18 , CD49d , and CD 54 on blood and peritoneal leukocytes was measured using flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of CD 8 , B 7 2 ( CD 86 ) , and to lesser extent MHCII , LFA 1 ( CD11a ) , and ICAM 1 ( CD 54 ) , was significantly enhanced at the invasion front of control tumors after LITT compared to hepatic resection . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Increased adhesion was not due to altered cell morphology or adhesion kinetics and occurred despite decreases in receptor expression ( CD 18 and CD11a ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
RESULTS : Good mobilizing patients , defined as those who collected their target in one apheresis procedure , had significantly fewer cells that expressed CD11a ( LFA 1 ) and CD 54 ( ICAM 1 ) and borderline fewer that expressed CD11c , CD49d ( VLA 4 ) , and CD49d ( VLA 5 ) . ^^^ Linear regression analysis identified number of prior chemotherapy courses and expression of CD11a ( LFA 1 ) as independent predictive factors for mobilization efficiency . ^^^ CONCLUSIONS : CD11a ( LFA 1 ) expression inversely correlates with mobilization efficiency . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In a group of patients with mild CRF we determined , at baseline and after in vitro activation with 4 phorbol 12 myristate 13 acetate ( PMA ) and N formyl methionyl leucyl phenylalanine ( fMLP ) , the polymorphonuclear leukocytes ( PMN ) beta 2 integrin pattern ( CD11a , CD11b , CD11c and CD 18 ) by using indirect immunofluorescence with a flow cytometer . ^^^ In normal subjects , after activation with both agents , we noted an increase of all adhesion molecules , while in CRF patients we found an increase in the expression of CD11b , CD11c and CD 18 but not of CD11a . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We investigated the expression of CD 226 and lymphocyte function associated antigen 1 ( LFA 1 ) ( CD11a ) during hemopoiesis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This was coupled with a significant up regulation of CD 18 and CD11a in splenic helper T cells and cytotoxic T cells , and of CD 18 in the circulating helper T cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Adhesion of both Mac 1 ( / ) and NIF ( + / + ) PMNs to endothelial cells in response to LPS was reduced in both types of PMNs and fully blocked only by the addition of anti CD11a monoclonal antibody . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In bone , ICAM 1 is expressed at the surface of osteoblasts ( Obs ) and its counter receptor , leukocyte function associated antigen 1 ( LFA 1 ; CD11a ) , at the surface of osteoclast ( Oc ) precursors . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The beta 2 integrins are found exclusively in leukocytes and they are composed of a common beta chain , CD 18 , and one of four unique alpha chains , CD11a ( alphaL subunit ) , CD11b ( alphaM subunit ) , CD11c ( alphaX subunit ) , or CD11d ( alphaD subunit ) . alphaX beta 2 which binds several ligands including fibrinogen and iC3b is expressed in monocytes / macrophages and dendritic cells playing an important role in the host defense . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The BoLFA 1 transductant expresses bovine CD 18 and CD11a as a heterodimer . ^^^ We found that LktA binds to both the CD 18 and CD11a subunits of BoLFA 1 cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
After hemolyzation with lysing solution , expression of CD11b , CD11a , CD 18 and CD49d on eosinophils was measured using flow cytometry . ^^^ RESULTS : The expression of CD11b , CD11a and CD 18 in allergic patients was significantly higher than that in normal subjects . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Flow cytometry revealed that PBMCs cultured with spermine decreased mean fluorescent intensities ( MFIs ) of CD11a and CD 18 in the lymphocyte light scattered region , but not in the monocyte region . ^^^ The decreases of CD11a and CD 18 MFIs were accompanied by the decrease in adherent capacity of PBMCs to HUVECs . ^^^ Polyamines , especially spermine , decrease LFA 1 ( CD11a / CD18 ) expression on human lymphocyte and adhesion capacity of PBMCs to HUVECs . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Neutrophils were treated with IL 15 and cell surface expression of CD11a , CD11b , CD11c and CD 18 was monitored by flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
On the fourth day of infestation , the results of flow cytometry indicated that 2 % of the host ' s splenocytes were expressing high levels of CD 49 ( alpha 4 integrin of VLA 4 ) and low levels of CD11a ( alphaL subunit of the integrin LFA 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In a group of 18 subjects with acute deep venous thrombosis ( DVT ) , evidenced by clinical examination and echo color Doppler , we examined the phenotypical expression of the polymorphonuclear leukocyte ( PMN ) beta 2 integrins ( CD11a , CD11b , CD11c , CD 18 ) , obtained by using a flow cytofluorimeter . ^^^ In DVT subjects , at baseline , the phenotypical expression of CD11b was decreased and that of CD11c was increased when compared with normal controls ; no difference was found in CD11a and CD 18 expression . ^^^ In normal subjects PMN activation with both activators led to a constant increase of all PMN adhesion molecules ; in DVT subjects CD11b , CD11c and CD 18 increased , while CD11a expression did not show any change . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To map the site involved in Mannheimia haemolytica leukotoxin ( LktA ) binding and biological activity within bovine CD 18 , bovine 10 human CD 18 chimeric constructs were generated and coexpressed with bovine CD11a in K 562 cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition , when myeloma cells were coincubated with 50 microM etodolac on bone marrow stromal cells ( BMSCs ) , myeloma cell adhesion to BMSCs was significantly inhibited compared with thalidomide or meloxicam coincubation , and the adhesion molecules VLA 4 , LFA 1 ( CD11a ) , CXCX 4 , and CD 44 were suppressed on myeloma cells treated with etodolac . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LktA binding to CD11a could be inhibited by a small molecule inhibitor of the 1 ( inserted ) domain , the major ligand binding interface on CD11a . 1 domain inhibition significantly blunts LktA induced intracellular calcium elevation and tyrosine phosphorylation of the CD 18 tail . ^^^ Furthermore , LktA also binds to the CD11a subunit of LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Along with the ovine CD 18 encoding cDNA , which is available for a few months , the sequence data provided here will allow the Ovis aries beta 2 integrin CD11a / CD18 ( LFA 1 , alpha ( L ) beta 2 ) expression in vitro as a tool to examine the specificities of inflammation in the ovine species . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Interesting was the broad species overlapping reactivity of mAb directed against CD 9 ( 11 out of 17 species ) , CD11a ( 11 / 17 ) , CD 14 ( 11 / 17 ) , CD 18 ( 13 / 17 ) , CD 21 ( 7 / 17 ) , CD 29 ( 10 / 17 ) , CD 44 ( 13 / 17 ) , CD 45 ( 9 / 17 ) , CD 47 ( 10 / 17 ) , and CD49d ( 13 / 17 ) , CD 61 ( 6 / 17 ) , CD 86 ( 7 / 17 ) , CD 91 ( 5 / 17 ) , and CD172a ( 10 / 17 ) , indicating evolutionary highly conserved epitopes on these surface molecules . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
BACKGROUND : Lymphocyte function associated antigen 1 ( LFA 1 , CD11a / CD18 , alpha L beta 2 ) is required for many cellular adhesive interactions during the immune response . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The CD11a partner in Sus scrofa lymphocyte function associated antigen 1 ( LFA 1 ) : mRNA cloning , structure analysis and comparison with mammalian homologues . ^^^ BACKGROUND : Lymphocyte function associated antigen 1 ( LFA 1 , CD11a / CD18 , alphaLbeta 2 ) , the most abundant and widely expressed beta 2 integrin , is required for many cellular adhesive interactions during the immune response . ^^^ RESULTS : The porcine LFA 1 CD11a ( alpha ) subunit coding sequence was cloned , sequenced and compared with the available mammalian homologues in this study . ^^^ CONCLUSION : Together with the pig CD 18 encoding cDNA , which has been available for a long time , the sequence data provided here will allow the successful expression of porcine CD11a , thus giving the first opportunity to express the Sus scrofa beta 2 integrin LFA 1 in vitro as a tool to examine the specificities of inflammation in the porcine species . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Wild type ( WT ) mice pretreated with neutralizing antibody against CD11a ( LFA 1 ) , CD11b ( Mac 1 ) , CD11a plus CD11b , or CD 18 alone failed to develop BP when injected with pathogenic anti mBP 180 IgG . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The lack of CD 18 results in the deficiency of all beta 2 integrins , i . e . , CD11a / CD18 ( LFA 1 ) , CD11b / CD18 ( Mac 1 / CR3 ) , CD11c / CD18 ( p 150 , 95 / CR4 ) , and CD11d / CD18 . ^^^ Similarly to CD 18 hypomorph mice , CD11c / mice expressed higher levels of MCP 1 , compared to both WT and CD11a / mice , as determined by in vitro analysis of MCP 1 secretion by bone marrow derived dendritic cells and in vivo analysis of MCP 1 mRNA expression in B . burgdorferi infected hearts . ^^^ Overall , our results suggest that the increased severity of Lyme carditis in CD 18 hypomorph mice is caused by deficiency in CD11a or CD11c , possibly via different mechanisms . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Here we show a crucial role for host MHC class 1 dependent NK cell reactivity for allograft tolerance in mice induced through either costimulation blockade using CD 154 specific antibody therapy or by targeting LFA 1 ( also known as CD11a ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
More infiltrating leukocytes ( CD 18 , CD11a , CD 44 ) and ED 1 positive macrophages were found in allografts of infected animals . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The leukocyte integrins CD11a / CD18 ( LFA 1 , alphaLbeta 2 ) and CD49d ( VLA 4 , alpha4beta1 , alpha4beta7 ) mediate leukocyte transendothelial migration during immune and inflammatory responses and provides co stimulatory signals for the activation of T lymphocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In this study , we examined the pathophysiological role of the beta ( 2 ) integrins CD 18 , CD11a , and CD11b in the pathogenesis of dextran sodium sulfte ( DSS ) induced experimental colitis . ^^^ The CD 18 null and CD11a null mice had significantly lower disease activity and cumulative histopathological scores compared to wild type mice . ^^^ Examination of specific leukocyte populations in the distal colon from various mice revealed significant attenuation of neutrophil and macrophage infiltrates in CD 18 , CD11a , and CD11b null mice . ^^^ This study demonstrates that genetic loss of CD 18 or CD11a is protective during experimental colitis and that CD11b may serve a regulatory role during development of disease . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Leukocytes were separated and stained with fluorescein isothiocyanate ( FITC ) conjugated mouse anti human CD11a , CD 18 , and CD 97 monoclonal antibodies for flow cytometry . ^^^ Significant decrease of CD11a density on monocytes , but markedly enhanced expression of CD 97 and CD 18 on polymorphonuclear neutrophil granulocytes ( PMN ) , and significantly increased proportion of CD 97 positive lymphocytes were found in the joint fluids as compared to the corresponding peripheral blood samples . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The LFA 1 ( CD11a and CD 18 ) integrin molecule is constitutively expressed on the T cell surface . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
T cells expressed CD 18 and CD11a with no expression of CD11b , whereas neutrophils expressed CD 18 , CD11a , and CD11b . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Efalizumab , a targeted inhibitor of T cell interactions , binds to the CD11a subunit of lymphocyte function associated antigen 1 ( LFA 1 ) , thereby preventing LFA 1 binding to intercellular adhesion molecule 1 ( ICAM 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The beta 2 integrin lymphocyte function associated antigen 1 ( LFA 1 ; CD11a / CD18 ) is important for lymphocyte trafficking and activation as well as recruitment to sites of tissue inflammation . ^^^ Transfer of CD4+CD25 T cells isolated from wild type ( wt ) mice into immunodeficient recipients [ recombinase activating gene 1 deficient ( RAG 1 / ] produced moderate to severe colitis , whereas RAG 1 / mice injected with CD11a deficient ( CD11a / ; LFA 1 / ) donor T cells displayed minimal macroscopic and histological evidence of colitis . ^^^ Taken together , our data suggest that T cell associated CD11a ( LFA 1 ) expression plays a dual role in the initiation of chronic gut inflammation by facilitating naive T cell priming / activation and expansion within MLNs and by augmenting pro inflammatory cytokine production following secondary stimulation by antigen presenting cells in the colonic interstitium . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Western analysis of soluble LFA 1 revealed a truncated 110 kDa CD11a chain and a minimally truncated 86 kDa CD 18 chain . ^^^ Here , we describe shedding of the integrin lymphocyte function associated antigen 1 ( LFA 1 ; CD11a / CD18 ) from human leukocytes during the cutaneous inflammatory response to the blistering agent cantharidin . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LFA 1 ( CD11a ) as a therapeutic target . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Leukocyte adhesion receptors ( LFA 1 ; Mac 1 ; p 150 , 95 ) are a family of heterodimeric cell surface adhesion molecules expressed exclusively in granulocytes , lymphocytes , and macrophages . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Plasmodium falciparum infected erythrocytes bind ICAM 1 at a site distinct from LFA 1 , Mac 1 , and human rhinovirus . ^^^ The ICAM 1 binding site is distinct from those recognized by LFA 1 , Mac 1 , and the human major type rhinoviruses . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To address the question whether leukocyte integrins are able to generate signals activating neutrophil functions , we investigated the capability of mAbs against the common beta chain ( CD 18 ) , or the distinct alpha chains of CR 3 , LFA 1 , or gp150 / 95 , to activate neutrophil respiratory burst . ^^^ Stimulation of neutrophils respiratory burst by both anti CD 18 , and anti LFA 1 or gp150 / 95 mAbs was totally inhibited by the microfilaments disrupting agent , cytochalasin B , and by a permeable cAMP analogue . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To address this question , we infected knockout ( KO ) mice that have defective expression of CD11a , CD11b , CD 18 , CD 62 , CD 103 , or beta 7 . ^^^ We found that the integrins CD11a and CD 18 are absolutely required for host resistance following infection with aerosolized M . tuberculosis . ^^^ Thus , LFA 1 ( CD11a / CD18 ) plays an essential role in immunity to M . tuberculosis infection . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The maximal free radical production and lag time of the free radical production of activated leukocytes were measured , and leukocyte adhesion molecules ( CD11a and CD 18 ) signing leucocyte activation were determined as well . ^^^ The CD11a and CD 18 expression of the granulocytes significantly decreased right after the revascularization , but with a gradual elevation , until the 7th day they exceed the ischaemic value . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Among them , CD 18 and its ligand ICAM 1 are particularly intriguing because CD 18 and its heterodimer binding chains CD11a and CD11b were correspondingly expressed in ex vivo expanded EPCs isolated from rat and murine bone marrows . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
BACKGROUND : Anti LFA 1 ( CD11a ) antibody increases allograft survival and / or induces tolerance in murine models , but its mechanisms of action remain to be elucidated . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
TRL 01 had the same immunophenotype as the original leukemia cells : positive for CD 13 , CD 33 , CD11a , CD 18 , CD 29 , CD49d , CD49e , CD 54 , CD62L , and CD 117 , and negative for CD 3 , CD 4 , CD 8 , CD 19 , CD 34 , CD41a , CD41b , CD 135 , and myeloperoxidase . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Over the past decade , Lymphocyte Function Associated Antigen 1 ( LFA 1 , alphaLbeta 2 , CD11a / CD18 ) has emerged as an attractive therapeutic target for the treatment of multiple inflammatory diseases . ^^^ Recent findings with different classes of small molecule antagonists will be highlighted with an emphasis on how their different mechanisms of action on the inserted domain ( 1 domain ) of CD11a have impacted our understanding of LFA 1 function and illuminated other potential avenues for therapeutic intervention . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule 1 ( ICAM 1 , CD 54 ) is a cell adhesion molecule that interacts with the leukocyte beta 2 integrins , LFA 1 and Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Antibody against the Leu CAM beta chain ( CD 18 ) promotes both LFA 1 and CR 3 dependent adhesion events . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Stimulation of cells with antibodies to the monocyte surface Ag MAC 1 , LFA 1 , and ICAM 1 did not result in M CSF secretion . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of LFA 1 ( CD11a / CD18 ) , a receptor for ICAM 1 , and other leukocyte adhesion molecules , including Mac 1 ( CD11b / CD18 ) and p 150 , 95 ( CD11c / CD18 ) , was only maintained by IL 2 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Dendritic cells displayed high forward and low intermediate side angle scatter , and expressed high levels of major histocompatibility complex ( MHC ) class 1 and class 2 molecules , the heat stable antigen ( HSA ) , the adhesion molecules Pgp 1 ( CD 44 ) , LFA 1 , ICAM 1 and low levels of Mac 1 and the leukocyte common antigen CD 45 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The role of the cytokines IL 1 alpha , IL 1 beta , and IL 6 and the cell adhesion molecules ICAM 1 , LFA 1 ( alpha and beta ) , and Mac 1 as accessory molecules for stimulation of T cells by the superantigen staphylococcal enterotoxin B ( SEB ) was examined . ^^^ The cell adhesion molecules ICAM 1 and LFA 1 but not Mac 1 also functioned as accessory molecules for SEB induced cluster formation and lymphocyte blastogenesis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The leukocyte integrins LFA 1 , Mac 1 and p 150 , 95 ( CD11a / CD18 , CD11b / CD18 , CD11c / CD18 ) mediate crucial leukocyte adhesive functions in immune and inflammatory reactions . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of the beta 2 integrins ( LFA 1 , CD11a / CD18 ; MAC 1 , CD11b / CD18 ; p 150 , 95 , CD11c / CD18 ) and ICAM 1 ( CD 54 ) by monocytes and granulocytes was studied using flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Our data show that ( 1 ) all three cell types express the CD 18 Ag of LFA 1 or Leu CAM , ( 2 ) rare KS cells from eyes can not cold target inhibit ECs , ( 3 ) KS cells express a distinct LAK cell Ag , which we have called LAK KS Ag , and ( 4 ) LAK KS Ag allows for cold target inhibition between different KS cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Exposure of LAK cells to mAb versus LFA 1 partially inhibited cytolysis ; mAb versus CD 18 inhibited cytolysis more completely . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
An immunodeficiency disease called `` leukocyte adhesion deficiency ( LAD ) ' ' that is defective in expression of leukocyte adhesion molecules of integrin family , LFA 1 , Mac 1 and p 150 , 95 , is discussed with special reference to its clinical features , laboratory findings , neutrophil functions , lymphocyte functions and molecular defects . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Homogeneous marrow stromal cell monolayers capable of supporting proliferation of cocultivated CD34hi cells expressed VCAM 1 and fibronectin ( ligands for VLA 4 and VLA 5 ) as well as ICAM 1 ( ligand for LFA 1 and Mac 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Generally , the lymphomatous cells also expressed high levels of MHC class 2 DR protein , CD 18 ( LFA 1 beta chain ) , and CD45RO . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Surface marker analysis showed an increased expression of F4 / 80 and Mac 1 on monocytes , Mac 1 expression on granulocytes and LFA 1 expression on resident peritoneal macrophages . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In normal skin positive staining for CD 18 was not observed , whereas in psoriasis both CD1a+ and CD1a DCs expressed beta 2 integrins , LFA 1 ( CD11a / CD18 ) , and gp 150 / 95 ( CD11c / CD18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In common with ICAM 1 and ICAM 2 , ICAM R is a ligand for the beta 2 integrin CD11a / LFA 1 ( CD 18 ) . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LFA 1 , Mac 1 , and p 150 , 95 are leukocyte adhesion proteins called beta 2 integrins . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Circulating integrins : alpha 5 beta 1 , alpha 6 beta 4 and Mac 1 , but not alpha 3 beta 1 , alpha 4 beta 1 or LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Addition of anti LFA 1 antibodies ( anti CD11a or CD 18 ) completely inhibited the lymphokine promoted aggregation , indicating that cluster formation was mediated by LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Soluble antibodies to LFA 1 or to the common beta chain ( CD 18 ) of the LFA 1 / CR3 / p150 , 95 family of cell adhesion molecules did not inhibit GBS uptake . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LFA 1 , Mac 1 , and p 150 , 95 comprise a family of cell surface glycoproteins that mediate adhesive interactions of myeloid and lymphoid cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Leukocyte adhesion deficiency is a disorder with mutations of the gene for the beta subunit , a component common to three adhesion molecules ; LFA 1 , Mac 1 and p 150 , 95 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
VLA 2 , VLA 5 , VLA 6 , LFA 1 , Mac 1 , p150 / 95 , beta 2 chain , HCAM , ICAM 1 , NCAM , and VCAM 1 were more expressed on ' normal ' as compared with ' leukemic ' bone marrow stromal cells , although this reached significance only for beta 2 chain and NCAM . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Leu CAMs ( CD11 / CD18 ) consisting of LFA 1 , Mac 1 , and p150 / 95 are leukocyte cell surface glycoproteins that are involved in various leukocyte functions . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Three leukocyte adhesion receptors have been described which mediate intercellular binding of leukocytes : LFA 1 ( CD11a / CD18 ) , Mac 1 ( CD11b / CD18 ) , and p150 / 95 ( CD11c / CD18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Both the integrins LFA 1 and Mac 1 bind to ICAM 1 , an immunoglobulin superfamily member . ^^^ Here , we show that the binding site on ICAM 1 for Mac 1 is unexpectedly distinct from that for LFA 1 and maps to the third NH 2 terminal immunoglobulin like domain . ^^^ Agents that interfere with carbohydrate processing provide evidence that the size of the N linked oligosaccharide side chains on ICAM 1 affects binding to Mac 1 but not to LFA 1 . ^^^ Thus , we suggest that the extent of glycosylation on ICAM 1 may regulate adhesion to LFA 1 or Mac 1 in vivo . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The elevated levels of cICAM 1 in LAD sera may be due to an inability to adsorb cICAM 1 to cell bound LFA 1 or may be an indirect result of the pathology accompanying the syndrome . cICAM 1 bound to mAb specific for four distinct ICAM 1 epitopes localized in domains D 1 , D 2 , D 4 , and D 5 , and displayed similar molecular size properties as recombinant soluble ICAM 1 on FPLC size exclusion chromatography . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
However , T dependent signalling of B cells was profoundly inhibited by mAb to CD 18 ( beta chain of LFA 1 ) on the T cell or CD 54 ( ICAM 1 ) on the B cell , demonstrating the importance of this pair of adhesion molecules in early T B cell interactions . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of lymphocyte function associated antigens , LFA 1 alpha / beta ( CD 11 a / 18 ) and LFA 3 ( CD 58 ) , involved in intercellular adhesion and the T cytotoxic pathway , were differentially regulated by EBV ; a crucial observation was the activation by immortalizing EBV isolates of LFA 1 beta chain ( CD 18 ) and of LFA 3 ( CD 58 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Leukocyte integrin P 150 , 95 ( CD11c / CD18 ) functions as an adhesion molecule binding to a counter receptor on stimulated endothelium . p 150 , 95 is a member of the beta 2 family of integrins , which includes both LFA 1 and Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Yet both anti CD 20 and anti IgM increase class 2 MHC , CD 18 ( LFA 1 beta chain ) and LFA 3 levels . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Blocking mAb directed to either CD11a / CD18 ( LFA 1 , a ICAM 1 counter receptor ) , CD11b / CD18 ( Mo 1 ) , or CD 18 ( common beta 2 integrin ) also blocked greater than 90 % of PMN transmigration . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition , CD 40 mAb induced increased surface expression of intercellular adhesion molecule 1 ( CD 54 ) , a ligand for CD11a / CD18 ( LFA 1 ) , and CD 18 mAb blocked aggregation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Addition of monoclonal antibodies 84H10 directed against ICAM 1 and MHM 23 directed against the common beta subunit of LFA 1 ( CD 18 ) resulted in greater than 50 % suppression of syncytia formation in cultures of these clones infected with cell free virus . ^^^ However , anti ICAM 1 and anti LFA 1 ( CD 18 ) antibodies did not reverse the TNF alpha induced enhancement of syncytia formation of HIV 1 infected clones 1B11 39 and 17D 9 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Neutrophil adhesion to interleukin 1 ( IL 1 ) stimulated human umbilical vein endothelial cells ( HUVEC ) involves the CD 18 family of leukocyte integrins ( lymphocyte function associated antigen 1 [ LFA 1 ] , Mac 1 , and p 150 , 95 ) and LECAM 1 ( DREG 56 / LEU 8 / LAM 1 antigen ) on neutrophils and intercellular adhesion molecule 1 ( ICAM 1 ) and endothelial leukocyte adhesion molecule 1 ( ELAM 1 ) on the endothelium . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LFA 1 , Mac 1 , and p 150 , 95 are a family of functionally important leucocyte integrins that share a common beta subunit and participate in cellular adhesion . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Consistent with this , homotypic adhesion induced by engagement of MHC class 2 antigens was observed with LFA 1 deficient B cell lines , and was independent of CD49d or CD 18 expression . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
HIV 1 infection of target monocytes or T cells by cell free virus was blocked completely or partially by some mAb that prevent cell cell interactions ( CD 4 , HLA DR , LFA 1 , LFA 3 ) , but not by others ( ICAM 1 , MAC 1 , gp150 . 95 , CD 2 , CD 3 , CD 14 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of LFA 1 , Mac 1 , and Mac 2 after this treatment was studied by FACS analysis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In order to avoid these pitfalls , we first isolated and cloned T lymphocytes from a patient with leukocyte adhesion deficiency ( LAD ) , an inherited disorder in which the defective expression of leukocyte integrins results in the production of LFA 1 T lymphocytes . ^^^ Using assay systems that did not involve LFA 1 mediated adhesion to antigen presenting cells or target cells , the T cell lines from the LAD patient were found to be intrinsically defective in all three of these parameters of T cell activation . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The characteristic changes in the surface markers ( Mac 1 , LFA 1 , and F4 / 80 ) of peripheral monocytes were also investigated in order to analyze the mechanism of protection by M CSF . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Adhesion of resting or activated neutrophils through the integrins LFA 1 and Mac 1 to ICAM 1 in a lipid bilayer does not occur at physiologic shear stresses ; however , static incubation of activated neutrophils allows development of adhesion that is greater than 100 fold more shear resistant than found on CD 62 . ^^^ Addition of a chemoattractant to activate LFA 1 and Mac 1 results in the arrest of neutrophils rolling on bilayers containing both CD 62 and ICAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The role of leukocyte function associated Ag 1 ( LFA 1 ) ( CD11a / CD18 ) in T cell endothelial cell ( EC ) interactions was assessed by utilizing CD11a / CD18 deficient T cell clones generated from a patient with leukocyte adhesion deficiency ( LAD ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We report the expression of LFA 1 and diethylaminoethyl ( DEAE ) Mac 1 alpha beta heterodimers on the cell surface of a fibroblastoid cell line , COS , by DEAE dextran cotransfection of the alpha and beta subunit cDNAs . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Leukocyte adhesion deficiency ( LAD ) is an inherited immunodeficiency disease that is characterized by the deficient expression of the leukocyte adhesion glycoproteins lymphocyte function associated antigen 1 ( LFA 1 ) , Mac 1 , and p 150 , 95 . ^^^ Here we demonstrate that expression of the LFA 1 alpha beta heterodimer in EBV transformed B lymphoblastoid cells from LAD patients can be recovered after transfection with the beta subunit cDNA contained in an EBV based vector . ^^^ Functional studies such as homotypic adhesion and adhesion to a purified counterreceptor for LFA 1 , intracellular adhesion molecule 1 , demonstrated that LFA 1 function had been restored in the stably transfected LAD patient cell lines . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LPG beads were unable to bind to macrophages isolated from individuals with a genetic deficiency in the CD 18 complex of leukocyte integrins ( CR 3 , p 150 , 95 , and LFA 1 ) , suggesting that one or more of these receptors were required for binding of LPG . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The monoclonal antibody IB 4 ( directed against CD 18 , the common beta subunit of structurally related adhesion receptors on phagocytes , LFA 1 , Mac 1 , and P 150 , 95 ) prevented the OZ mediated increase in PMN adherence to endothelial cells and the increase in endothelial permeability to 125I albumin . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We assessed the ability of a monoclonal antibody ( MoAb ) ( hybridoma : SP2 / 0 Ag . 14XBALB / c spleen cells ; isotype : murine IgG 1 ) to CD 18 that recognizes the beta chain of LFA 1 ( CD11a / CD18 ) , MAC 1 ( CD11b / CD18 ) and CD11c / CD18 to effect the neutrophils response to the proinflammatory chemotaxins leukotriene B 4 ( LTB 4 ) and 12 ( R ) hydroxy 5 , 8 , 11 , 14 eicosatetraenoic acid [ 12 ( R ) HETE ] in the mouse dermis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Transfected murine L cells or monkey COS cells expressing human ICAM 1 bind to purified Mac 1 in a specific and dose dependent manner ; the attachment to Mac 1 is more temperature sensitive , lower in avidity , and blocked by a different series of ICAM 1 mAbs when compared to LFA 1 . ^^^ In a reciprocal assay , COS cells cotransfected with the alpha and beta chain cDNAs of Mac 1 or LFA 1 attach to immunoaffinity purified ICAM 1 substrates ; this adhesion is blocked by mAbs to ICAM 1 and Mac 1 or LFA 1 . ^^^ Two color fluorescence cell conjugate experiments show that neutrophils stimulated with fMLP bind to HUVEC stimulated with lipopolysaccharide for 24 h in an ICAM 1 , Mac 1 , and LFA 1 dependent fashion . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Pretreatment of PMN with IB 4 , a MAb to the CD 18 integrin , the common beta subunit of the adhesion proteins LFA 1 , Mac 1 , and p 150 , 95 of PMN , reduced the increases in PMN adherence and the endothelial monolayer permeability induced by the 6 hr TNF alpha treatment . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
With respect to the mechanism underlying defective macrophage adherence in EFA deficiency , no change in the expression of cell surface adherence molecules ( Fc receptor , Mac 1 , or LFA 1 ) was noted with the deficiency state . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
It was proposed recently that LFA 1 and Mo 1 ( CD 18 family ) and GPIIb IIIa might be encoded by the same gene . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This rat alpha 1 sequence also contains a 206 amino acid 1 domain , inserted between repeats 2 and 3 , that is homologous to 1 domains found in the same position in the alpha subunits of several integrins ( VLA 2 , Mac 1 , LFA 1 , p 150 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Pretreatment of lymphocytes with antibodies against CD 11a and CD 18 ( LFA 1 alpha and beta chain , respectively ) could decrease the lymphocyte binding , whereas ICAM 1 pretreatment of tissue sections was ineffective . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The CD 11 complex is part of a larger complex composed of four glycoproteins ( CDw 18 ) precipitated by MoAb 60 . 3 , with properties suggesting that the CDw 18 complex is equivalent to the Mac 1 , LFA 1 , p 150 , 95 glycoprotein family implicated in adherence dependent leukocyte functions . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
These anti LFA 1 mAb did not bind to the Mac 1 positive P388D1 cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Regulated expression of the Mac 1 , LFA 1 , p 150 , 95 glycoprotein family during leukocyte differentiation . ^^^ The regulation of Mac 1 , LFA 1 , and p 150 , 95 expression during leukocyte differentiation was examined . ^^^ The resultant Mac 1 , LFA 1 , p 150 , 95 phenotype resembled hairy cell leukemia , a B cell plasmacytoid leukemia . ^^^ These cells acquired a Mac 1 , LFA 1 , p 150 , 95 profile that resembled that of granulocytes , with more Mac 1 than p 150 , 95 induced . ^^^ The contributions of Mac 1 , LFA 1 , and p 150 , 95 to aggregation of PMA differentiated U 937 cells were assessed . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Moreover , the NH 2 terminal protein sequence of the 125 kDa chain was homologous with the NH 2 terminal sequences of two other cell surface proteins , lymphocyte function associated antigen 1 ( LFA 1 ) and macrophage antigen 1 ( Mac 1 ) , which have been implicated as receptors for adhesion proteins of leukocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The molecule recognized by KB 90 appears to correspond to the p150 / 95 molecule in the family of leucocyte differentiation antigens of which the LFA 1 and Mac 1 molecules are members . ^^^ These reactions are clearly distinct from those of the LFA 1 and Mac 1 molecules . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of LFA 1 beta chain ( CD 18 ) did not correlate significantly with stage or survival , but had prognostic value in a subgroup of HR expression negative lymphomas ( P = 0 . 03 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LFA 1 , Mac 1 , and CD 45 ) but expressed ICAM 1 , NCAM , J11d , CD 44 , and MHC molecules . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Other PMN surface markers ( My 4 , My 7 , ICAM 1 , LFA 1 , LFA 3 , Mac 1 ) did not change significantly . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Leukocyte adherence is mediated by a superfamily of glycoproteins denoted LFA 1 ( the lymphocyte function associated antigen 1 ) , Mac 1 ( macrophage antigen 1 ) and p 150 , 95 . ^^^ The pkC stimulated adherence of monocytes to endothelium was inhibited by the presence of a monoclonal antibody to Mac 1 , while monoclonal antibodies to p 150 , 95 and LFA 1 did not influence adherence . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Using immunoprecipitation , sodium dodecyl sulfate gel electrophoresis , immunofluorescence and flow cytometry , we have studied the expression of LAR in human CD5+ B cells from chronic lymphocytic leukemia ( B CLL ) patients . 170 , 95 kDa Mac 1 and p 150 , 95 , as well as 180 , 95 kDa LFA 1 heterodimers are shown to be co expressed on CD5+ mu + kappa + B cells from a patient where they retain their known function in homotypic cell cell adhesion . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Function and regulation of the neutrophil MEL 14 antigen in vivo : comparison with LFA 1 and MAC 1 . ^^^ The CD11 / 18 ( LFA 1 , Mac 1 ) molecules participate in neutrophil adhesion to cultured endothelium in vitro and are critical for effective neutrophil localization into inflamed tissues in vivo . ^^^ In contrast , Mac 1 is up regulated on inflammatory neutrophils and little change is seen in the level of LFA 1 expression . ^^^ Anti LFA 1 , anti Mac 1 , or MEL 14 antibody given i . v . suppress neutrophil accumulation within the inflamed peritoneum ( 38 % , 30 % , and 37 % of medium control , respectively ) without affecting the levels of circulating neutrophils . ^^^ Finally , in ex vivo adhesion assays of neutrophil binding to high endothelial venules in inflamed lymph node frozen sections MEL 14 inhibits greater than 90 % . anti LFA 1 20 to 30 % and anti Mac 1 less than 10 % of the binding of bone marrow neutrophils to inflamed lymph node high endothelial venules . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD 18 antibodies react with the common beta chain of the human leukocyte function antigen ( LFA 1 ) * and thus block the functions mediated by the three identified molecules in humans . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Compared with non neoplastic leukocytes , large malignant lymphocytes appeared either negative or only weakly positive for the leukocyte surface glycoprotein , CD 18 that is the beta chain of the CDIIa / CD18 complex ( lymphocyte function associated antigen 1 , LFA 1 ) , which mediates cell to cell adhesion of lymphocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Cell to cell contact enhances the proliferation of acute myeloid leukemia ( AML ) cells in vitro without an apparent role of adhesion glycoproteins LFA 1 , MAC 1 and P 150 95 . ^^^ The role of the leukocyte function antigens ( LFA ) LFA 1 , Mac 1 , P 150 95 in this phenomenon was then analyzed , as these structurally related glycoproteins are involved in reactions requiring contact between hematopoietic cells . ^^^ LFA 1 , Mac 1 and P 150 95 were expressed on the AML cells of 15 , 6 and 8 patients , respectively . ^^^ Thus , no direct role for LFA 1 and / or Mac 1 and / or P 150 95 antigens in mediating contact induced AML proliferation could be demonstrated . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Serum E 27 appears to be directed at determinants of the LFA 1 alpha chain and not the beta chain since it immunoprecipitated LFA 1 molecules but not the Mac 1 molecules . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Receptor identity was explored using antibodies to the leukocyte adhesive receptors Mac 1 , LFA 1 , and p150 . 95 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Conjugation was also inhibited by an antibody ( MHM 23 ) recognizing the beta chain shared by LFA 1 , MAC 1 , and P150 / 95 molecules . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Depletion of CD 4 ( OKT 4 ) , HLADR ( OKIa ) , or LFA 1 ( MAC 1 ) positive populations failed to reduce NK activity . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LFA 1 , an antigen involved in cytolytic T lymphocyte mediated killing , and Mac 1 , the receptor for complement component C3bi , constitute a family of structurally and functionally related cell surface glycoproteins involved in cellular interactions . ^^^ In both mouse and man , Mac 1 ( OKM 1 ) and LFA 1 share a common 95 kDa beta subunit but are distinguished by their alpha chains , which have different cellular distributions , apparent molecular masses ( 165 and 177 kDa , respectively ) , and peptide maps . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Patients with recurring , life threatening bacterial infections have been identified who have moderate ( 95 % ) or severe ( greater than 99 % ) deficiency of Mac 1 and of the related LFA 1 and p 150 , 95 molecules . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The antiserum reacted with p 150 , 95 and two other antigens with the same beta subunit , Mac 1 and lymphocyte function associated antigen 1 ( LFA 1 ) . ^^^ While LFA 1 appears very early in neutrophil maturation , it is becoming clear that Mac 1 and p 150 , 95 are upregulated from an intracellular storage pool of peroxidase negative granules that appear during the myelocyte stage of differentiation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We present evidence that SGP 140 is distinct from the glycoprotein family ( Mac 1 , LFA 1 , and p150 / 95 [ CDw 18 ] ) that performs adhesive reactions of leukocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Neutrophil adherence to human endothelium in vitro occurs by CDw 18 ( Mo 1 , MAC 1 / LFA 1 / GP 150 , 95 ) glycoprotein dependent and independent mechanisms . ^^^ Components of the CDw 18 leukocyte surface glycoprotein complex ( Mo1 / LFA 1 / GP 150 , 95 or MAC 1 , LFA 1 family ) are required for some adhesion related functions of human neutrophils ( PMNs ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Their overall structures and biochemical properties are similar to those of a group of vertebrate receptors , including those for fibronectin , fibrinogen and vitronectin , and also the leukocyte antigens Mac 1 , LFA 1 and p 150 , 95 and the VLA family of cell surface antigens . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
These receptors are not part of the Mac 1 , LFA 1 , p ( 150 , 95 ) family , but do have homology to the platelet Fn receptor , gpIIb / IIIa . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A new finding is the blockage of helper T cell proliferation by anti Mac 1 as well as with anti LFA 1 antibodies , showing that accessory molecules may be as important as specific recognition of class 2 antigen molecules in the control of thymocyte proliferation and hence in thymocyte selection . ^^^ Mac 1 , like LFA 1 , belongs to a novel family of differentiation antigens involved in cell interactions . ^^^ The mechanism of syngeneic proliferation inhibition by anti Ia , anti Mac 1 , and LFA 1 antibodies may be the prevention of IL 2 receptor expression on thymocytes , and / or the inhibition of IL 2 secretion . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We have isolated cDNA clones encoding the beta subunit of the human LFA 1 , Mac 1 , and p 150 , 95 family of leukocyte adhesion proteins . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition , the alpha subunits from the LFA 1 , Mac 1 ( CR 3 ) , and p 150 , 95 family of heterodimers , the vitronectin receptor platelet GPIIb / IIIa family , and a position specific ( PS ) antigen important in Drosophila embryogenesis each showed average homologies of 31 40 % to individual VLA alpha sequences and 46 52 % homology to VLA alpha subunits including conservative substitutions . ^^^ Taken together , these results suggest that the VLA proteins , the LFA 1 , Mac 1 , and p 150 , 95 family , the GPIIb / IIIa , vitronectin receptor family , and the Drosophila PS antigens have evolved as four subgroups in a highly conserved supergene family of receptors involved in fundamentally important functions , such as cell adhesion , migration , and embryogenesis . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LFA 1 , Mac 1 and P150 / 95 ] . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The functional role of the LFA 1 molecule in the interaction between helper T lymphocytes and B lymphocytes was investigated using lymphocytes from patients with leukocyte adhesion deficiency , an inherited immunodeficiency characterized by a defective leukocyte expression of the LFA 1 , Mac 1 ( CR 3 ) and p 150 , 95 molecules . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA 1 , Mac 1 and p 150 , 95 . ^^^ The adhesion receptors Mac 1 , LFA 1 , and p 150 , 95 are cell surface alpha / beta heterodimers that play a key role in leukocyte adhesion processes . ^^^ The genes for Mac 1 , LFA 1 , and p 150 , 95 alpha subunits have been located to chromosome 16 by means of Southern blot analysis using a series of somatic cell hybrids . ^^^ The gene encoding the LFA 1 / Mac 1 / p150 , 95 beta subunit , and defective in leukocyte adhesion deficiency , has been located on chromosome 21 , band q 22 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of Mac 1 ( 3 , 4 fold increase ) was consistently enhanced more than p 150 , 95 ( 1 . 4 fold increase ) and LFA 1 expression was unchanged . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Both the LFA 1 antigen ( CD 11a , CD 18 ) and the IgG Fc receptor Fc gamma Rlow ( CD 16 ) are functionally relevant for the activation of these cells . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
At the second relapse , the cells from this patient expressed another myeloid associated antigen , LFA 1 molecule , recognized by the monoclonal antibody M 232 ( CD 18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A report that anti CD 18 ( LFA 1 ) antibodies blocked the UCHT 1 response with human monocytes raised the possibility that this molecule might also be involved in accessory function . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Mac 1 , LFA 1 human leukocyte adhesion glycoprotein family . ^^^ Monoclonal antibodies specific for p 150 , 95 , a third member of the Mac 1 and lymphocyte function associated antigen 1 ( LFA 1 ) leukocyte adhesion protein family , have been identified and used to study the biochemistry and cellular expression of p 150 , 95 . p 150 , 95 is a noncovalently associated heterodimer containing alpha 10 and beta subunits of Mr = 150 , 000 and 95 , 000 respectively . ^^^ Findings suggest that the p 150 , 95 alpha 10 beta complex shares a common beta subunit with the alpha L beta LFA 1 and alpha M beta Mac 1 complexes . ^^^ Patients with a previously demonstrated genetic deficiency in Mac 1 and LFA 1 fail to express p 150 , 95 . ^^^ Deficiency of the Mac 1 , LFA 1 , and p 150 , 95 alpha beta complexes on the surface of patient cells appears due to a defect in the common beta subunit . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The glycosylation and polypeptide chain length of the p 150 , 95 , Mac 1 , and lymphocyte function associated antigen ( LFA 1 ) alpha and beta subunits were compared by immunoprecipitation with subunit specific MAb and antisera , and by digestion with Endo H and N glycanase . ^^^ Mac 1 and LFA 1 alpha subunits have precursors of 160 , 000 Mr and 165 , 000 Mr , respectively , and contain N linked carbohydrates . ^^^ The polypeptide chain length for the Mac 1 alpha subunit is 137 , 000 Mr , and for LFA 1 is 149 , 000 Mr . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Periodontal manifestations of the heritable Mac 1 , LFA 1 , deficiency syndrome . ^^^ The clinical , histopathologic and functional consequences of the genetic deficiency of leukocyte Mac 1 , LFA 1 and p 150 , 95 were assessed among three affected patients , heterozygotes and unaffected individuals among two generations of a single kindred . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Differential function of LFA 1 family molecules ( CD 11 and CD 18 ) in adhesion of human monocytes to melanoma and endothelial cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The leukocyte adhesion receptors , p 150 , 95 , Mac 1 and LFA 1 are integral membrane glycoproteins which contain distinct alpha subunits of 180 , 000 150 , 000 Mr associated with identical beta subunits of 95 , 000 Mr in alpha beta complexes . p 150 , 95 alpha subunit tryptic peptides were used to specify oligonucleotide probes and a cDNA clone of 4 . 7 kb containing the entire coding sequence was isolated from a size selected myeloid cell cDNA library . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Binding of the adhesive protein complex ( LFA 1 / Mac 1 / p150 , 95 ) to concanavalin A . ^^^ Immunoprecipitation of the labeled proteins after solubilization in non ionic detergents , with monoclonal antibodies ( MAbs ) directed against a family of leukocyte membrane proteins ( LFA 1 , Mac 1 , p 150 , 95 , and the beta subunit these glycoproteins share ) , indicated that Mac 1 and p 150 , 95 were bound by Con A . ^^^ Similar experiments in a patient deficient in LFA 1 , Mac 1 , p 150 , 95 , and the beta subunit confirmed that Mac 1 alpha and the beta subunit were important Con A binding proteins . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To further investigate cell surface molecules concerned with platelet function , antisera against mouse platelets , thymocytes , and macrophages and monoclonal antibodies against Mac 1 ( complement receptor type 3 ) and leukocyte function associated glycoprotein type 1 ( LFA 1 ) were used to demonstrate LFA 1 like molecules on mouse platelets . ^^^ The alpha subunits of platelet and thymocyte LFA 1 showed identical electrophoretic mobility but differed significantly from the alpha subunit of macrophage Mac 1 . ^^^ Peptide mapping demonstrated the identity of the beta subunits of these three molecules but showed that the alpha subunit of Mac 1 was distinct from the alpha subunits of platelet and thymocyte LFA 1 . ^^^ Human platelets , which are inactive in immune adherence assays , are shown to lack LFA 1 and Mac 1 . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
MAb directed at the alpha subunits of Mac 1 ( alpha M ) , LFA 1 ( alpha L ) , p 150 , 95 ( alpha 10 ) , or their common beta subunit were used to characterize the contributions of the Mac 1 glycoprotein family to granulocyte adherence reactions . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The mouse leukocyte adhesion proteins Mac 1 and LFA 1 : studies on mRNA translation and protein glycosylation with emphasis on Mac 1 . ^^^ Translation in vitro of mRNA and immunoprecipitation with specific rabbit antisera showed that the unglycosylated precursor polypeptides of the mouse Mac 1 and lymphocyte function associated antigen ( LFA 1 ) alpha subunits are 130 , 000 Mr and 140 , 000 Mr , respectively . ^^^ The Mac 1 and LFA 1 alpha subunit translation products are immunologically noncross reactive , showing that differences between these related proteins are not due to post translational processing . ^^^ Mac 1 and LFA 1 alpha subunits could only be in vitro translated from mRNA from cell lines the surfaces of which express the corresponding Mac 1 and LFA 1 alpha beta complexes , showing tissue specific expression is regulated at the mRNA level . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The importance of the Mac 1 , LFA 1 glycoprotein family in monocyte and granulocyte adherence , chemotaxis , and migration into inflammatory sites : insights from an experiment of nature . ^^^ The Mac 1 , LFA 1 ( lymphocyte function associated 1 ) , p 150 , 95 family of glycoproteins , which share a common beta subunit of Mr 95 000 , are of widespread importance in leucocyte adhesion reactions . ^^^ Antibodies to the common beta subunit , to the Mac 1 alpha subunit , and to a lesser extent to the LFA 1 and p 150 , 95 alpha subunits , inhibit many of the same functional responses by normal cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The amino acid sequence of the amino termini of platelet GPIIb alpha and GPIIb beta and of the alpha chains of the leukocyte LFA 1 and Mac 1 glycoprotein complexes had significant sequence homology . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Patients with an inherited deficiency of the adherence glycoproteins LFA 1 , Mac 1 , and p 150 , 95 are unable to mobilize polymorphonuclear leukocytes ( PMNLs ) to peripheral sites of inflammation . ^^^ LFA 1 / Mac 1 / p150 , 95 deficient PMNL exhibited profoundly impaired movement stimulated by chemotactic factors when the cells were required to move over two dimensional surfaces . ^^^ No deficiency of translational mobility of PMNL from LFA 1 / Mac 1 / p150 , 95 deficient patients was observed in collagen gels . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Leukocyte adhesion deficiency : an inherited defect in the Mac 1 , LFA 1 , and p 150 , 95 glycoproteins . ^^^ These include Mac 1 ( complement receptor type 3 ) , lymphocyte function associated antigen 1 ( LFA 1 ) , and p 150 , 95 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
By immunofluorescence analysis , CD11b and CD 18 monoclonal antibodies specific for the 155 kd alpha polypeptide of Mo 1 ( gp 155 , 94 ) and the 94 kd beta peptide common to Mo 1 , LFA 1 ( gp 170 , 94 ) , and Leu M 5 ( p 150 , 94 ) ( surface molecules that promote leukocyte adhesion ) failed to bind to unstimulated and A 23187 calcium ionophore stimulated granulocytes or mononuclear cells of the affected dog as compared with strong specific binding to canine control cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The genetic deficiency of leukocyte surface glycoprotein Mac 1 , LFA 1 , p 150 , 95 in humans is associated with defective antibody dependent cellular cytotoxicity in vitro and defective protection against herpes simplex virus infection in vivo . ^^^ The role of the Mac 1 , LFA 1 , p 150 , 95 leukocyte glycoprotein family in mediating antiviral host defense was investigated by utilizing mononuclear cells ( MC ) obtained from eight patients with a genetic deficiency of Mac 1 , LFA 1 , and p 150 , 95 , and normal MC incubated with subunit specific monoclonal antibodies ( MAb ) directed against these glycoproteins . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Differential subunit association affects the site specific glycosylation of the common beta chain from Mac 1 and LFA 1 . ^^^ This cell line simultaneously synthesizes two structurally related glycoproteins , Mac 1 and LFA 1 . ^^^ Mac 1 and LFA 1 each contain two subunits in noncovalent association in an alpha 1 beta 1 structure . ^^^ For both Mac 1 and LFA 1 , the association of the alpha and beta chains occurs prior to any Golgi mediated processing of the oligosaccharide moieties on either one of the subunits . ^^^ To evaluate the effects of differential subunit association on the site specific glycosylation of the beta chain , [ 3H ] glucosamine labeled oligosaccharides were isolated from the beta chain of Mac 1 and LFA 1 and were compared by a variety of enzymatic and chromatographic techniques . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The function of LFA 1 in cell mediated killing and adhesion : studies on heritable LFA 1 , Mac 1 deficiency and on lymphoid cell self aggregation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Leukocyte adhesion deficiency ( LAD ) is a heritable disease involving deficient expression of three related leukocyte adhesion glycoproteins : LFA 1 , Mac 1 , and p 150 , 95 . ^^^ Mutant beta subunit precursors from LAD patients failed to associate with the LFA 1 alpha subunit . ^^^ Heterogeneous mutations in the beta subunit common to the LFA 1 , Mac 1 , and p 150 , 95 glycoproteins cause leukocyte adhesion deficiency . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Three membrane proteins , Mac 1 , LFA 1 , and p 150 , 95 each consisting of a specific alpha subunit and a beta subunit common to them , have been reported to be deficient in neutrophils from several patients with a neutrophil adhesion disease . ^^^ Using monoclonal antibodies to Mac 1 alpha , LFA 1 alpha , and to the beta subunit , it was deduced that the siblings ' neutrophils lacked the above three membrane proteins . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Sequence homology of the LFA 1 and Mac 1 leukocyte adhesion glycoproteins and unexpected relation to leukocyte interferon . ^^^ The lymphocyte function associated 1 ( LFA 1 ) and macrophage 1 ( Mac 1 ) glycoproteins mediate differing types of adhesion reactions on these cells . ^^^ LFA 1 participates in T lymphocyte and natural killer cell adhesion to target cells , whereas the Mac 1 antigen is identical to the complement receptor type 3 , which mediates adhesion of monocytes and granulocytes to C3bi sensitized particles . ^^^ LFA 1 and Mac 1 resemble one another in overall structure , having alpha subunits of relative molecular mass ( Mr ) 180 , 000 and 170 , 000 , respectively , which are non covalently associated with beta subunits of Mr 95 , 000 in alpha 1 beta 1 complexes . ^^^ Nonetheless , the shared beta subunit suggested that LFA 1 and Mac 1 might be members of a protein family containing diversified but evolutionarily related alpha subunits . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The LFA 1 , Mac 1 leucocyte adhesion glycoprotein family and its deficiency in a heritable human disease . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The LFA 1 , Mac 1 glycoprotein family and its deficiency in an inherited disease . ^^^ Soon after these molecules and at least some of their functions had been defined with monoclonal antibodies , an inherited disease , LFA 1 , Mac 1 deficiency , was discovered in humans . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Two well characterized antigens [ Mac 1 and lymphocyte function associated antigen ( LFA 1 ) ] , expressed on a variety of leukocytes , are members of a family of surface proteins associated with multiple recognition functions . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The severe and moderate phenotypes of heritable Mac 1 , LFA 1 deficiency : their quantitative definition and relation to leukocyte dysfunction and clinical features . ^^^ As shown with subunit specific monoclonal antibodies in immunofluorescence flow cytometry and 125I immunoprecipitation techniques , in addition to a NaB3H4 galactose oxidase labeling assay , granulocytes , monocytes , or lymphocytes from these individuals had a `` moderate ' ' or `` severe ' ' deficiency of Mac 1 , LFA 1 , or p 150 , 95 ( or a combination ) three structurally related `` adhesive ' ' surface glycoproteins . ^^^ The recognition of phenotypic variation among patients with Mac 1 , LFA 1 deficiency may be important with respect to therapeutic strategies . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Inherited deficiency of the Mac 1 , LFA 1 , p 150 , 95 glycoprotein family and its molecular basis . ^^^ The glycoproteins , Mac 1 , LFA 1 , and p 150 , 95 , have the subunit compositions alpha M beta , alpha L beta , and alpha 10 beta , respectively . ^^^ Using subunit specific monoclonal antibodies , both the alpha M and beta subunits of Mac 1 , the alpha L and beta subunits of LFA 1 , and at the least the beta subunit of p 150 , 95 , were found to be deficient at the cell surface by the techniques of immunofluorescence flow cytometry , radioimmunoassay , and immunoprecipitation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LFA 1 and Lyt 2 , 3 , molecules associated with T lymphocyte mediated killing ; and Mac 1 , an LFA 1 homologue associated with complement receptor function . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Mapping of antigenic and functional epitopes on the alpha and beta subunits of two related mouse glycoproteins involved in cell interactions , LFA 1 and Mac 1 . ^^^ Mouse Mac 1 , a complement receptor associated surface structure on macrophages , and LFA 1 , a function associated structure on lymphocytes , comprise a novel family of leukocyte differentiation antigens participating in adhesive cell interactions . ^^^ Mac 1 and LFA 1 contain alpha subunits of 170 , 000 and 180 , 000 Mr , respectively , and beta subunits of 95 , 000 Mr noncovalently associated in alpha 1 beta 1 complexes . ^^^ Cross reactive epitopes on Mac 1 and LFA 1 were found to be present on the beta subunits , which were immunologically identical . ^^^ Non cross reactive epitopes that are distinctive for Mac 1 or LFA 1 were localized to the alpha subunits . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Mac 1 NK that lysed Yac 1 displayed Qa 5 , LFA 1 , asialo GM 1 , Ly 5 . 1 , and NK 1 . 2 , but not Lyt 1 , Lyt 2 , Mac 2 , Mac 3 , or Mac 4 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Most clones express Thy 1 , Pgp 1 , ICAM 1 , HSA and B 220 antigen , but are negative for LFA 1 , CD 2 , Mel 14 , Fc receptor , Mac 1 , CD 4 and CD 8 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Compared with LFA 1 and Mac 1 , p 150 , 95 is less well functionally characterized . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In dermal vascular injury , a requirement for Mac 1 ( CD11b / CD18 ) but not for leukocyte function associated antigen 1 ( LFA 1 , CD11a / CD18 ) has been established . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In the sputum and peripheral blood eosinophils of asthmatics , Mac 1 was strongly expressed and LFA 1 , VLA 4 and sLe 10 were also expressed . ^^^ In addition , immunoreactivities of Mac 1 , LFA 1 , and VLA 4 were detected in eosinophils infiltrated into the bronchial submucosa , but sLe 10 was weakly detected . ^^^ These results suggest that binding between ICAM 1 and Mac 1 or LFA 1 , VCAM 1 and VLA 4 , not but ELAM 1 and sLe 10 , is mainly involved in eosinophil infiltration into the airway in allergic reaction such as bronchial asthma . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
No change in the expression of the beta 2 integrins Mac 1 and LFA 1 was apparent on peripheral blood neutrophils of the IL 8 transgenic mice . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Purification and structural characterization of LFA 1 , a lymphocyte function associated antigen , and Mac 1 , a related macrophage differentiation antigen associated with the type three complement receptor . ^^^ LFA 1 , an antigen associated with antigen specific T lymphocyte mediated killing , and Mac 1 , a macrophage differentiation antigen associated with type three complement receptor function , contain alpha chains of Mr = 180 , 000 and 170 , 000 , respectively , and beta chains of Mr = 95 , 000 . ^^^ The LFA 1 and Mac 1 beta chains are highly homologous or identical , whereas the alpha chains are highly different by tyrosyl tryptic peptide mapping ( Krzinger , K . , Ho , M . ^^^ T lymphoma cell lines express LFA 1 but not Mac 1 as shown by immunofluorescence and immunoprecipitation . ^^^ Conversely , some macrophage like lines express Mac 1 but not LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This study was designated to investigate the expression of three adhesion molecules ICAM 1 ( CD 54 ) , VCAM 1 , and ELAM 1 , and the counter ligands LFA 1 ( CD 18 ) , Mac 1 ( CD 11b / CD 18 ) , and VLA 4 ( CD 49d ) in frozen sections of endomyocardial biopsies ( EMB ) of heart allografts in relation to onset of CMV infection recorded as CMV antigenemia . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Four lines of evidence suggest that most are basophils : ( 1 ) The cells fulfill morphologic criteria for light microscopy . ( 2 ) Cell surface markers determined by immunofluorescence and flow cytometry revealed that the IgE bearing cells express the leukocyte antigens Fc gamma RII and the beta 2 integrins , LFA 1 and Mac 1 , but do not express the mast cell associated c kit receptor for stem cell factor . ( 3 ) The late phase histamine containing cells in late phase BAL fluids have the functional characteristics of basophils in their secretory responses to anti IgE , the f met peptide , and phorbol ester TPA . ( 4 ) The cells have a functional histamine type 2 receptor , a characteristic of basophils , not mast cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Quantitation of PMN adhesion molecules revealed a loss of L selectin ( 8 + / 5 % of control group , n = 3 ) , an increase in Mac 1 ( 776 + / 82 . 60 % of control group , n = 3 ) , and no change in LFA 1 when normal PMNs were incubated with plasma from rats pretreated with 4 LPS ( P < 0 . 05 ) . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
By immunohistochemical analysis , Mac 1 , LFA 1 , and VLA 4 were strongly positive in eosinophils and mononuclear cells infiltrated in the bronchial mucosa and submucosa . ^^^ Immunolocalization for ICAM 1 , the ligand of Mac 1 and LFA 1 , was detected in the endothelial cells of capillaries and venules , in the mononuclear cells in submucosa , and in the basal layer of the epithelium . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Three other ATL cell lines ( TL OmI , H 582 , HuT 102 ) were found to have little mRNA for the LFA 1 beta chain ( CD 18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Blocking mAbs to lymphocyte function associated antigen 1 ( LFA 1 ) , Mac 1 , and very late activation antigen 4 ( VLA 4 ) were used to evaluate the role of these integrins in the migration . ^^^ Migration to the joints was not inhibited by treatment of the animals with mAb to LFA 1 , Mac 1 , or VLA 4 alone , and was partially ( 50 % ) inhibited in only the most arthritic joint , the talar joint , by the combination of mAb to LFA 1 plus Mac 1 . ^^^ Treatment with the combination of the three mAbs to LFA 1 , Mac 1 , and VLA 4 completely eliminated monocyte migration to all joints and dermal inflammation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast , LFA 1 ( CD 18 ) expression was unaffected . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Differential expression of ICAM 1 , VCAM 1 and their ligands LFA 1 , Mac 1 , CD 43 , VLA 4 , and MHC class 2 antigens in murine Toxoplasma encephalitis : a light microscopic and ultrastructural immunohistochemical study . ^^^ Microglia also expressed Mac 1 and leukocyte function associated antigen 1 ( LFA 1 ) , which are both ligands of ICAM 1 , as well as CD 45 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We previously reported that mAb directed against the beta 2 chain of the leukocyte function associated antigen 1 ( LFA 1 ) adhesion molecule ( CD 18 ) blocked the invasion of LB cells into the spleen but not into the lymph nodes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
RESULTS : Infiltrating lymphocytes expressed LFA 1 , LFA 2 , VLA 4 , and VLA 5 , whereas some of the macrophages were also positive for p150 / 95 and MAC 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Keratinocytes at sites of cutaneous inflammation have increased expression of intercellular adhesion molecule 1 ( ICAM 1 ) , a cytokine inducible adhesion molecule which binds the leukocyte integrins LFA 1 and Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
T cell clones were treated with 3 distinct DNA methylation inhibitors or were stably transfected with a CD 18 cDNA in a mammalian expression vector , and the effects on LFA 1 expression and activation requirements were examined . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The effects of this mAb were compared with those of another anti rat CD 18 mAb which potently blocks the LFA 1 / Intercellular adhesion molecules ( ICAMs ) interactions . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
T lymphocytes and neutrophils tether and roll on plastic immobilized PNAd and E selectin at 1 . 8 dyn / cm2 wall shear stress , but fail to interact with immobilized ICAM 1 , a ligand for LFA 1 and Mac 1 , at the same flow rate . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The profound pathogenesis of the LAD has been defined as impairments in adhesion dependent leukocyte functions such as chemotaxis due to a lack of leukocyte cell surface expression of adhesion molecules of LFA 1 , Mac 1 and p150 / 95 , the beta 2 integrin . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
It is therefore of interest to evaluate eosinophil activation via intercellular adhesion molecule 1 ( ICAM 1 ) and the beta 2 integrin family , namely CR 3 ( Mac 1 ) , lymphocyte function associated antigen ( LFA ) 1 alpha and LFA 1 beta , which are ligands for ICAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibody to CD 18 , the beta chain of LFA 1 , did not induce this phenotype . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Stimulation of neutrophils with CBR LFA 1 / 2 induces binding to ICAM 1 through activation of both LFA 1 and Mac 1 . ^^^ Activation of Mac 1 by CBR LFA 1 / 2 was further confirmed by stimulation of neutrophil binding to fibrinogen , a ligand for Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The second conditioning regimen consisted of TBI and chemotherapy with the use of anti lymphocyte function associated antigen 1 ( LFA 1 ) and anti CD 2 monoclonal antibodies for patients with the moderate phenotype of LAD . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To study the influence of the cellular environment on the functional activity of leukocyte integrins and to analyze their involvement in hematopoietic cell differentiation , we have developed stable transfectants of LFA 1 , Mac 1 , and p 150 , 95 ( CD11a c / CD18 ) leukocyte integrins in cultured cell lines whose differentiation can be induced in vitro . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition , consecutive sections were stained with MoAbs against LFA 1 , CD45RO ( UCHL 1 ) DR human leucocyte antigen ( HLA DR ) , CD11b / CD18 ( Mac 1 ) , and CD11c / CD18 ( p 150 , 95 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : We analyzed the immunohistochemical localization of the adhesion molecules ( ICAM 1 , LFA 1 , Mac 1 , VCAM 1 , VLA 4 , P and E selectins ) in IBD , stressing phenotypical changes of endothelial cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Proliferation is also inhibited by mAbs to T cell CD 2 and LFA 1 beta chain ( CD 18 ) and by mAbs to LFA 3 ( CD 58 ) and CD 44 , which are expressed by T cells and EC . mAb to ICAM 1 ( CD 54 , a ligand for LFA 1 ) provides inconsistent inhibition , and mAb to ICAM 2 , used with or without anti ICAM 1 , is not inhibitory . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Cells with Langerhans ' cell histiocytosis morphology were stained for ICAM 1 , for the beta 1 integrins alpha 4 ( VLA 4 ) and alpha 5 ( VLA 5 ) , and for the beta 2 integrins LFA 1 , MAC 1 and p 150 , 95 . ^^^ They were less reactive than the cells of Langerhans ' cell histiocytosis for alpha 4 ( VLA 4 ) and LFA 1 , were positive for MAC 1 and p 150 , 95 and were characterized by prominent expression of the beta 1 integrins alpha 2 ( VLA 2 ) , alpha 3 ( VLA 3 ) and of VnR ( alpha v / beta 3 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
KIM 185 , a monoclonal antibody to CD 18 which induces a change in the conformation of CD 18 and promotes both LFA 1 and CR 3 dependent adhesion . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Despite extensive differences in N linked glycosylation , ICAM 3 purified from lymphoid cells and from neutrophils supports adhesion of LFA 1 bearing cells equally well ; however , neither supports adhesion of Mac 1 or p 150 , 95 expressing chinese hamster ovary cell transfectants . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The new compounds were shown to inhibit neutrophil adherence under conditions in which adherence is mediated by Mac 1 ( CD11b / CD18 ) and LFA 1 ( CD11a / CD18 ) ; they thus appear to target beta 2 integrins in their antiadhesion activity . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Residues critical for human ICAM 1 binding to the beta 2 integrin leukocyte function associated antigen 1 ( LFA 1 ) are highly conserved between all species , whereas those residues demonstrated to play an important role in interaction of human ICAM 1 with macrophage activation complex 1 ( Mac 1 ) are not highly conserved . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In vivo blood monocyte migration to acute inflammatory reactions , IL 1 alpha , TNF alpha , IFN gamma , and C5a utilizes LFA 1 , Mac 1 , and VLA 4 . ^^^ The role of the monocyte integrins , Mac 1 , LFA 1 , and VLA 4 , on the adhesion of rat blood monocytes to rat microvascular endothelial cells in vitro and the importance of these receptors in monocyte migration to inflammation in vivo were evaluated . ^^^ Monocyte adhesion to cytokine ( IL 1 , IFN gamma , and TNF alpha ) stimulated endothelial cells was mediated by Mac 1 , LFA 1 , and VLA 4 , but Mac 1 appeared to be less important than LFA 1 or VLA 4 . ^^^ Anti Mac 1 mAb treatment had no effect , whereas anti LFA 1 inhibited migration to C5a and the cytokines by 20 to 40 % . ^^^ Blocking both Mac 1 and LFA 1 decreased monocyte accumulation by 50 to 70 % to all stimuli . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This liver associated lymphocyte population also presented a significantly higher percentage of Mac 1 , ICAM 1 , and LFA 3 and an increased surface expression of LFA 1 , LFA 2 , and NCAM in comparison with peripheral blood lymphocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Furthermore , in the liquid culture of bone marrow cells in the presence of IL 13 , the number of CD 14 ( monocyte macrophage antigen ) positive cells decreased and CD 18 ( LFA 1 beta ) positive cells increased . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD11a / CD18 ( LFA 1 ) , CD11b / CD18 ( Mac 1 ) and CD11c / CD18 ( p 150 , 95 ) were monitored before and after standard cold and heat tests in 8 females with Raynaud ' s Disease and 8 matched controls . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The analyzed molecules included the beta 1 integrin or VLA family VLA 1 6 , the beta 2 integrins or leukocyte integrins LFA 1 , Mac 1 , and p 150 , 95 , the immunoglobulins LFA 3 , CD 2 , ICAM 1 and VCAM 1 and the selectins ELAM 1 and GMP 140 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Such studies have demonstrated that engagement of CD 18 , the beta subunit of the lymphocyte function related antigen 1 ( LFA 1 ) and major histocompatibility complex class 2 ( MHC 2 ) enhanced HIV replication . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Similarly , blood derived human phagocytes were stimulated to express adhesion molecules ( LFA 1 , MAC 1 , p 150 , 95 , ICAM 1 ) , to synthesize TNF alpha and IL 2 , and to develop a natural killer activity . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We show that the neutrophils from localized juvenile periodontitis patients with decreased neutrophil chemotaxis and increased adherence exhibit increased expression of the CD11 / CD18 family of adherence molecules , Mac 1 , leukocyte function associated antigen ( LFA 1 ) and p 150 , 95 , as compared with neutrophils obtained from systemically and periodontally healthy controls . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Our previous study revealed high expression of beta 2 integrin family ( CR 3 , LFA 1 alpha , CD 18 ) on hypodense eosinophils . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
It was found that a number of adhesion molecules , such as CD 2 , CD 4 , CD 8 , LFA 1 , CD 18 , ICAM 1 and Thy 1 , was partly involved in the nursing activity . ^^^ The inhibitory effect of mAb to CD 2 , LFA 1 , CD 18 and ICAM 1 on thymocyte engulfment was higher than their effect on thymocyte binding to the R TNC . 1 line . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition to these activities LFA 1 and ICAM 1 are implicated in the cell to cell transmission of human immunodeficiency virus ( HIV 1 ) since antibodies to CD 18 , CD 54 or synthetic peptide analogs of ICAM 1 antagonise the formation of virus induced syncytia ( Fecondo et al . , 1993 ; Gruber et al . , 1991 ; Hildreth and Orentas , 1989 ; Valentin et al . , 1990 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Antibodies to the beta 2 ( CD 18 ) chain of LFA 1 interfered with induction of p 120 , p 106 , and p 90 during cellular aggregation . ^^^ Although the role of LFA 1 dependent tyrosine phosphorylation in B cells is uncertain , patients with the leukocyte adhesion defect ( LAD ) exhibit humoral abnormalities . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Leukocyte adhesion deficiency ( LAD ) is an autosomal recessive disease caused by heterogeneous mutations within the gene encoding the common beta subunit ( CD 18 ) of the three leukocyte integrins LFA 1 ( CD11a / CD18 ) , Mac 1 ( CD11b / CD18 ) , and p 150 , 95 ( CD11c / CD18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Our results demonstrate that whereas expression of major histocompatibility complex ( MHC ) molecules , CD 45 , Mac 1 , LFA 1 , B cell markers , macrophage markers and some T cell markers ( as CD 2 , CD 4 and CD 8 ) did not undergo changes in culture , the level of expression of the adhesion molecules VLA 4 and ICAM 1 , and the T cell markers CD 5 , CD 25 and Thy 1 increased after 14 h incubation at 37 degrees C . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
As studies with adherent neutrophils indicated that TNF might act as activating leucocyte integrins to deliver signals involved in activation of cell functions , we investigated the effects of monoclonal antibodies ( mAb ) directed against VLA 4 ( CD49d / CD29 ) , LFA 1 ( CD11a / CD18 ) , CR 3 ( CD11b / CD18 ) or the common beta 2 subunit ( CD 18 ) on generation of eosinophil toxic oxygen molecules and spreading . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule 1 ( ICAM 1 ) is one of three immunoglobulin superfamily members that bind to the integrins lymphocyte function associated 1 ( LFA 1 ) and Mac 1 on leukocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The MMB3 . 19 line was derived from a B 6 mouse and expresses monocyte / macrophage markers , including Mac 1 , Mac 2 , F4 / 80 , and LFA 1 , in addition to H 2 class 1 and class 2 molecules . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
As reviewed above , leucocyte motility involves cell adhesion mediated by a class of molecules termed leucocyte integrins ( beta 2 integrins ) which vary in their alpha subunits and share CD 18 as a common beta subunit ( CD11a / CD18 = LFA 1 , CD11b / CD18 = Mac 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibody against LFA 1 ( CD 18 ) inhibits cellular and vascular rejection in rabbit cardiac allografts ] . ^^^ Results suggests that monoclonal antibody against LFA 1 ( CD 18 ) may hold promise as a therapeutic agent for both cellular and vascular rejection . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We have previously found that polymorphonuclear leukocyte ( PMNL ) migration to adjuvant arthritic joints of rats was only partially inhibited by mAbs to the adhesion molecules LFA 1 ( CD11a / CD18 ) and Mac 1 ( CD11b / CD18 ) , suggesting that there is a CD11 / CD18 independent mechanism for PMNL migration to inflamed joints . ^^^ This migration to the joints was not inhibited by mAbs to LFA 1 alone or mAbs to LFA 1 plus Mac 1 that almost completely inhibited PMNL accumulation in dermal inflammatory reactions induced by zymosan activated serum ( C5adesArg ) , endotoxin , IL 1 alpha , or TNF alpha in the same rats . ^^^ Intra articular injection of the cytokines IL 1 alpha and TNF alpha , but not IFN gamma , induced marked PMNL accumulation in the joints ; this was strongly inhibited by the treatment of rats with anti LFA 1 and anti Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In vitro binding of the monocytes was inhibited by mAbs against ICAM 1 , LFA 1 , CD 18 , and MAC 1 ; MAC 1 did not influence lymphocyte binding , although the other mAbs were effective . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
These data suggest that , in this model of neutrophil activation , the pathway for O 2 generation is a Mac 1 ( but not LFA 1 ) dependent pathway and also requires iC3b . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD 18 positive cells ( beta chain of antigen LFA 1 ) , cells CD11b+ , CD4+ , CD8+ and CD3+ were quantified in the blood of 32 acute leukemia patients , 38 chronic lymphoid leukemia patients and 15 mature cell lymphosarcoma patients . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We distinguish four categories of markers , which are characteristic of : ( 1 ) macrophage precursors and immature macrophages ( ER MP 12 , ER MP 20 , ER MP 54 , ER MP 58 ) ; ( 2 ) mature macrophages in general ( F4 / 80 , BM 8 , Mac 1 , Mac 2 , ER BMDM 1 ) ; ( 3 ) macrophage subsets ( ER HR 3 , ER MP 23 , ER TR 9 , Forssman antigen , MOMA 1 , MOMA 2 , Monts 4 , SER 4 ) , and ( 4 ) IFN gamma stimulated macrophages ( H 2Ia , LFA 1 , ICAM 1 , 158 . 2 , MBR 2 , TM 2 , TM 4 , and TM 5 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The adhesion molecule ICAM 1 mediates leucocyte adhesion to target structures and other immune cells by binding with the leucocyte adhesion receptors LFA 1 and MAC 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Increased adhesion is mediated through CD 18 ( LFA 1 / Mac 1 ) . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Signal transduction via phosphorylated adhesion molecule , LFA 1 beta ( CD 18 ) , is increased by culture of natural killer cells with IL 2 in the generation of lymphokine activated killer cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Immunohistochemical staining was used to document the serial expression of Mac 1 , intercellular adhesion molecule 1 ( ICAM 1 ) , and lymphocyte function associated antigen 1 ( LFA 1 ) in eyes of C3H / HeN mice with endotoxin induced uveitis . ^^^ Intercellular adhesion molecule 1 was first expressed on the ciliary body epithelium 6 hr after endotoxin injection and Mac 1 and LFA 1 were expressed on infiltrating inflammatory cells 12 hr after endotoxin injection . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
All of the internalized CD 18 was associated with alpha M ( CR 3 ) ; no endocytosis of alpha L ( LFA 1 ) was observed . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule , a ligand for the leucocyte integrins CD11a / CD18 ( LFA 1 ) and CD11b / CD18 ( Mac 1 ) , that plays an important role in a variety of inflammatory and immune mediated mechanisms , is strongly expressed in retroocular connective tissue from patients with Graves ' ophthalmopathy ( GO ) and involved in lymphocyte attachment to cultured retroocular fibroblasts via the ICAM 1 / LFA 1 mediated pathway . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Dendritic cells expressed major histocompatibility ( MHC ) class 1 and class 2 molecules , the leucocyte common antigen CD 45 , the rat leucocyte antigen OX 44 , the rat macrophage marker ED 1 , and the adhesion molecules Mac 1 , LFA 1 and ICAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Mac 1 and LFA 1 , members of the leukocyte or CD 18 integrin subfamily of adhesion molecules , rapidly change from a low avidity to a high avidity state on activation of neutrophils by various agonists . ^^^ We have focused on identifying cytoskeletal proteins that interact with the cytoplasmic domain of the beta subunit ( beta 2 or CD 18 ) common to the leukocyte subfamily of integrins , which include LFA 1 , Mac 1 , and p 150 , 95 . ^^^ Mac 1 and LFA 1 , members of the leukocyte or CD 18 integrin subfamily of adhesion molecules , rapidly change from a low avidity to a high avidity state on activation of neutrophils by various agonists . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To determine that the protective effect of MAb R15 . 7 was based on functional blocking of CD 18 , additional experiments were performed with identical concentrations of MAb 3 . 1 , which binds to the alpha subunit of LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Several functional defects have been found in neutrophils from leukocyte adhesion deficiency ( LAD ) patients who fail to express the CD11 / CD18 leukoadhesins : Mo 1 , LFA 1 , and p 150 , 95 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Leukocytes , including granulocytes and lymphocytes , from the LAD show defect in adhesion molecules of beta 2 integrin , LFA 1 , Mac 1 and p 150 , 95 , on its leukocyte membrane surface . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The role of the leukocyte adhesion molecules VLA 4 , LFA 1 , and Mac 1 in allergic airway responses in the rat . ^^^ The leukocyte adhesion molecules VLA 4 of the beta 1 integrin family , and LFA 1 and Mac 1 of the beta 2 family have a demonstrated role in leukocyte endothelial adherence and may play a role in airway inflammation in asthma . ^^^ We studied the effects of blocking VLA 4 ( CD49d / CD29 ) and both LFA 1 ( CD11a / CD18 ) and Mac 1 ( CD11b / CD18 ) airway responses and inflammation in rats . ^^^ Twelve rats were treated prior to challenge with anti rat VLA 4 monoclonal antibody ( mAb ) , 10 rats received both anti LFA 1 and anti Mac 1 mAb , and 14 rats received a control mAb . ^^^ The early response was significantly decreased in both the anti VLA 4 group ( 131 % baseline RL ) and the anti LFA 1 / Mac 1 group ( 118 % ; p < 0 . 05 ) compared with the control group ( 202 % ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Granulocytes from venous blood samples were separated on a Ficoll Hypaque gradient and the phenotypical expression of CD11a / CD18 ( LFA 1 ) , CD11b / CD18 ( Mac 1 ) and CD11c / CD18 ( p 150 , 95 ) was observed by double indirect immunofluorescence using specific monoclonal antibodies . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The mechanism underlaying this activation appear to involve the interaction of ICAM 3 with a beta 2 integrin , likely to be LFA 1 , since mAb to the CD 18 chain completely inhibited T cell activation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
They comprise 3 elements : LFA 1 ( CD11a / CD18 ) expressed at the surface of leucocytes , and in particular lymphocytes , M 01 or MAC 1 ( CD11b / CD18 ) , and p 150 . 95 ( CD11c / CD18 ) expressed only on granulocytes , monocytes and macrophages . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD 23 ligation promoted the expression of the monocyte marker , CD 14 , increased the expression of the common beta chain of the LFA 1 family ( CD 18 ) , and down regulated the expression of the promonocytic marker CD 33 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The panel of adhesion molecules studied included HLA ABC , HLA DR , CD 3 , LFA 1 , MAC 1 , ICAM 1 , PECAM 1 , VCAM 1 , and E selectin 1 . ^^^ RESULTS : The adhesion molecules ICAM 1 , HLA DR , PECAM 1 , CD 3 , VCAM 1 , LFA 1 , and MAC 1 were selectively expressed in areas of corneal inflammation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Epidermotropic neutrophilic granulocytes express MAC 1 ( CD11b / CD18 ) rather than LFA 1 ( CD11a / CD18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Finally , both LFA 1 ( CD11a / CD18 ) and Mac 1 ( CD11b / CD18 ) beta 2 integrins were required as well as the endothelial adhesion molecules E selectin and ICAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The molecules we analyzed included the VLA family VLA 1 6 , the leukocyte integrins LFA 1 , Mac 1 and p 150 , 95 , the immunoglobulins LFA 3 , CD 2 , ICAM 1 and VCAM 1 and the selectin ELAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The leukocyte specific integrins CD11a / CD18 ( lymphocyte function associated antigen 1 ( LFA 1 ) ) and CD11b / CD18 ( complement type 3 receptor ( Mac 1 ) ) , which bind to the intercellular adhesion molecules ICAM 1 and ICAM 2 , play a key role in adhesion . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The beta 2 integrins ( LFA 1 , Mac 1 , and p 150 , 95 ) are critical for many adhesive functions of leukocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Reactivity of LIL 13 with leukocyte function antigen 1 ( LFA 1 ) was excluded by competitive IIF and cytotoxicity tests with cross reacting anti human CD 18 or anti swine LFA 1 specific antibodies . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In this study we investigated the effect of EM on peripheral neutrophil adhesion molecules such as LFA 1 and Mac 1 obtained from six healthy subjects . ^^^ Pretreatment of neutrophils with each concentration ( 10 ng / ml approximately 100 micrograms / ml ) of EM resulted in no significant reduction in the expression of LFA 1 alpha , beta and Mac 1 . ^^^ These findings indicate that EM does not directly reduce the expression of LFA 1 alpha , beta and Mac 1 on peripheral neutrophil obtained from healthy subjects . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Receptors for the beta 2 integrin family ( LFA 1 and Mac 1 ) were not found , nor were receptors of the beta 3 integrin family , GPIIIa . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A major portion of polymorphonuclear leukocyte and T lymphocyte migration to arthritic joints in the rat is via LFA 1 / MAC 1 independent mechanisms . ^^^ However , the role of CD11 / CD18 molecules and their subtypes , such as LFA 1 and MAC 1 , in leukocyte migration to arthritis is not known . ^^^ Anti MAC 1 combined with anti LFA 1 did not inhibit PMNL or T lymphocyte migration to joints any more than anti LFA 1 alone . ^^^ However , the addition of anti MAC 1 to anti LFA 1 further inhibited PMNL migration to acute dermal inflammation by up to 90 % . ^^^ Furthermore , while LFA 1 and MAC 1 on PMNL and LFA 1 on T lymphocytes mediate much of the migration to dermal inflammation , the migration of these cells to arthritis has a major LFA 1 / MAC 1 independent component . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monoclonal antibodies against the LFA 1 subunit of the leukocyte adherence complex CD 18 inhibited the binding of marrow megakaryocytes or CMK cells to HUVEC . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
After whole blood lysis preparation , leukocytes were incubated with fluorescent antibodies to label LAM CD 11A / 18 ( LFA 1 ) , CD 11B / 18 ( Mac 1 ) , CD 11C / 18 ( p150 / 95 ) , and CD 54 ( ICAM 1 ) ( Becton Dickinson , San Jose , CA ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
METHODS : Immunohistochemical analysis was used to determine the distribution of the following adhesion molecules : lymphocyte function associated antigen 1 ( LFA 1 ; CD11a / CD18 ) , Mac 1 and p150 / 95 ( CD11bc / CD18 ) , intercellular adhesion molecule 1 ( ICAM 1 ) , and CD 44 in tissue sections from the ankle joints of rats with AIA . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Cytofluorimetric analysis of the NB 4 cell membrane molecules confirmed the increase under ATRA of VLA 4 , LFA 1 , MAC 1 and ICAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Blocking monoclonal antibodies ( mAbs ) to both LFA 1 and Mac 1 together , as well as a mAb to CD 18 , inhibited neutrophil accumulation in the inflamed joints by 50 75 % . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Mononuclear cells bearing CD 13 , CD 14 , CD 33 and HLA DR with macrophage like morphology were accumulated in the perivascular area and expressed VLA 4 , LFA 1 and Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Here we show that LFA 1 and Mac 1 can bind to ICAM 1 in the mouse as well . ^^^ Interestingly , we observed that binding of murine LFA 1 dominates over Mac 1 for binding to ICAM 1 . ^^^ Using three different murine macrophage cell lines that express distinct levels of LFA 1 and Mac 1 on their cell surface , we could only detect Mac 1 dependent adhesion to ICAM 1 when little or no LFA 1 is expressed on the cell surface . ^^^ When LFA 1 and Mac 1 are expressed at similar levels , the LFA 1 / ICAM 1 interaction dominates over Mac 1 / ICAM 1 interaction , indicating that there is a competition of LFA 1 and Mac 1 for ICAM 1 binding . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Cross linking of the alpha subunits of the beta 2 integrins demonstrated that only cross linking of Mac 1 but not LFA 1 or gp150 / 95 triggered tyrosine signaling . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Leukocyte adhesion deficiency ( LAD ) is a rare inherited immunodeficiency that is characterized by deficiency of the beta 2 integrin leukocyte adhesion molecules Mac 1 , LFA 1 , and p 150 , 95 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LFA 1 , and not Mac 1 , is crucial for the development of hyperreactivity in a murine model of nonallergic asthma . ^^^ Monoclonal antibodies ( mAbs ) directed against the alpha chains of LFA 1 ( FD441 . 8 ) and Mac 1 ( M1 / 70 ) were injected intravenously 2 h before and 2 h after the challenge . ^^^ Treatment with anti LFA 1 mAb totally inhibited the development of tracheal hyperreactivity measured 24 h after the challenge , whereas anti Mac 1 mAb had only a partial effect on this response . ^^^ The decrease in T cells in the blood , which was also evident 24 h after the challenge , was totally inhibited by treatment with anti LFA 1 , whereas anti Mac 1 had little effect . ^^^ The increase in the number of neutrophils in BALF at this time point was completely inhibited by both anti LFA 1 and anti Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule 1 ( ICAM 1 ) is a member of the immunoglobulin superfamily that interacts with two integrins , LFA 1 and Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The changes in expression of LFA 1 on monocytes , MAC 1 on granulocytes and p 150 , 95 ( CD11c / CD18 ) on monocytes and granulocytes during and after the operation did not reach statistical significance . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Our results also indicate that viral pathogenicity is associated with increased migration of inflammatory cells expressing VLA alpha 4 , LFA 1 alpha , Mac 1 alpha , ICAM 1 , and beta 2 integrin into the intestinal mucosa . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Granulocyte ( PMN ) and monocyte ( MNC ) expression of LFA 1 , Mac 1 , and CD 45 at the start ( t 0 ) , t 1 and t 2 was quantitated by flow cytometry analysis , after staining of the cells with specific fluorescinated monoclonal antibodies . ^^^ Again , no significant difference was found between NSBD and UPBD in LFA 1 , Mac 1 and CD 45 expression on PMN and MNC , during both CU and PAN HD . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule 1 ( ICAM 1 , CD 54 ) , an adhesion molecule of the immunoglobulin superfamily , is an endothelial cell surface ligand for such leukocyte integrins as lymphocyte function associated molecule 1 ( LFA 1 , CD11a / CD18 ) , Mac 1 ( CD11b / CD18 ) and CD 43 . ^^^ We examined the expression of ICAM 1 in renal tissues of Masugi nephritis rats and directly examined the role of ICAM 1 by administration of neutralizing monoclonal antibodies ( MAbs ) to rat ICAM 1 , LFA 1 alpha subunit ( LFA 1 alpha ) , beta subunit ( LFA 1 beta ) and Mac 1 alpha subunit ( Mac 1 alpha ) . ^^^ Proteinuria was significantly suppressed by the MAbs against ICAM 1 , Mac 1 alpha and LFA 1 beta . ^^^ These results indicate that both ICAM 1 / LFA 1 and ICAM 1 / Mac 1 pathways are involved in neutrophil infiltration into the glomeruli . ^^^ On the other hand , monocytic infiltration was prevented by the MAbs against ICAM 1 , LFA 1 alpha and LFA 1 beta but not by anti Mac 1 alpha MAb . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Addition of mAb to LFA 1 to mAb to Mac 1 did not result in greater inhibition . ^^^ This was in contrast to PMNL migration through human umbilical vein endothelium ( HUVE ) monolayers , where mAb to LFA 1 or to Mac 1 each partially inhibited PMNL transendothelial migration , and when these mAbs were combined , synergistic inhibition of migration was observed , reaching 90 95 % inhibition . ^^^ The results demonstrate the beta 2 integrin dependent PMNL migration in connective tissue may involve primarily Mac 1 , with little involvement of LFA 1 or ICAM 1 , a situation in marked contrast to PMNL migration across endothelium . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Furthermore , the adhesion strengthening interaction observed for healthy neutrophils could be specifically inhibited by monoclonal antibodies ( mAbs ) to Mac 1 , but not to lymphocyte function associated antigen 1 ( LFA 1 ; CD11a / CD18 ) or intercellular adhesion molecule 2 ( ICAM 2 ; CD 102 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Its ligands are the membrane bound integrin receptors LFA 1 and Mac 1 on leukocytes , CD 43 , the soluble molecule fibrinogen , the matrix factor hyaluronan , rhinoviruses , and Plasmodium falciparum malaria infected erythrocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Activated polymorphonuclear leukocytes induce constriction of canine coronary artery via Mac 1 , but not LFA 1 , and ICAM 1 . ^^^ The PMN induced vasoconstriction ( 5 10 10 ( 6 ) cells / ml : 98 + / 8 % of KCl induced constriction ) was inhibited when PMNs were pretreated with the monoclonal antibody against Mac 1 ( 54 + / 4 % of KCl induced constriction ) but not against LFA 1 against ICAM 1 ( 31 + / 2 % of KCl induced constriction ) . ^^^ These results suggest that activated PMNs may mediate adherent dependent constriction of canine coronary artery via Mac 1 ( CD11b / CD18 ) , but not LFA 1 ( CD11a / CD18 ) , with ICAM 1 . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
METHODS : The expression of the integrin VLA beta 1 , alpha subunits of the beta 2 integrins LFA 1 , Mac 1 , and p 150 , 95 , the members of the immunoglobulin family ICAM 1 and VCAM 1 , and the selectin ELAM 1 on corneas with bullous keratopathy ( BK ) secondary to intraocular surgery was studied immunohistochemically using an APAAP method . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
OBJECTIVE : Because recruitment and retention of lymphoid cells appear to be critical components of the pathogenesis of lichen planus , we have compared the expression and distribution of a panel of vascular adhesion molecules ( ELAM 1 , P selectin , ICAM 1 , VCAM 1 , PECAM 1 , CD 34 ) and leukocyte adhesion molecule ligands ( LFA 1 , Mac 1 , VLA 4 , L selectin ) in biopsies of this disease . ^^^ Almost all cells in the lichen planus infiltrates stained positive for ICAM 1 , L selectin , LFA 1 , and VLA 4 , and large numbers of cells also exhibited VCAM 1 , PECAM 1 , and Mac 1 immunoreactivity . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
These experiments were carried out in the presence of neutralising antibodies to CD 18 , CD11b , LFA 1 , E selectin , P selectin , intracellular adhesion molecule 1 ( ICAM 1 ) , and ICAM 2 ; a novel CD11b / CD18 antagonist , neutrophil inhibitory factor ( rNIF ) ; adenosine receptor agonists ( 5 ' N ethycarboxamido adenosine / N6 cylopentyladenosine ( NECA / CPA ) ) and a platelet activating factor ( PAF ) receptor antagonist lexipafant . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Anti integrin ( LFA 1 , VLA 4 , and Mac 1 ) antibody treatment and acute cardiac graft rejection in the rat . ^^^ Current experiments were designed to examine the effect of blocking Mac 1 , an important monocyte adhesion receptor and mediator of monocyte migration , together with anti LFA 1 and anti VLA 4 antibodies on cardiac graft survival and on the graft rejection pattern . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Experiments using monoclonal antibodies to block LFA 1 , Mac 1 , and p 150 , 95 ( three integrins vital for cell cell interactions ) mimic BLAD symptomatology and have led to the discovery of the reciprocal Intercellular Adhesion Molecule ( ICAM ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
By using polarized monolayers of human intestinal epithelia ( T 84 ) , PMN transepithelial migration has been shown to be dependent on the leukocyte integrin CD11b / CD18 ( Mac 1 ) , but not on CD11a / CD18 ( LFA 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To help define the role of adhesion molecules in HAM / TSP , we studied the expression of lymphocyte function associated antigen 1 ( LFA 1 ) , Mac 1 , very late antigen 4 ( VLA 4 ) , Sialyl Lewisx ( SLex ) , intercellular adhesion molecule 1 ( ICAM 1 ) , vascular cell adhesion molecule 1 ( VCAM 1 ) , endothelial leukocyte adhesion molecule 1 ( ELAM 1 ) and monocyte chemoattractant protein 1 ( MCP 1 ) in the spinal cord lesions of HAM / TSP . ^^^ Although the expression of ICAM 1 in the spinal cords was not distinctive between HAM / TSP and controls , infiltrating mononuclear cells in the spinal cords of HAM / TSP strongly expressed LFA 1 and Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Experiments with monoclonal antibodies to block LFA 1 , Mac 1 , and p 150 , 95 ( three integrins vital for cell cell interactions ) mimic BLAD symptomatology and have led to the discovery of the reciprocal intercellular adhesion molecule ( ICAM ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The number of LFA 1 and Mac 1 positive macrophages within the nerves was significantly reduced when liposomes were injected shortly after nerve transsection . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Secondly , IL 2 withdrawal resulted in a retarded apoptotic response in LFA 1 ( CD11a / CD18 ) negative T cells obtained from a leukocyte adhesion deficiency ( LAD ) patient , as compared to LFA 1 positive T cell lines . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
By flow cytometry , it could be shown that among several surface adhesion molecules ( ICAM 1 / CD54 , VLA 4 / CD49d , Mac 1 / CD11b , LFA 1 / CD11a , LFA 2 / CD2 , LFA 3 / CD58 , VCAM 1 ) , only the constitutively expressed immunoglobulin family member intercellular adhesion molecule 1 ( ICAM 1 ) is modulated by proinflammatory cytokines on HMC 1 mast cells . ^^^ This cytokine induced upregulation of ICAM 1 expression might reveal a putative regulatory mechanism of mast cell interaction with effector cells bearing the counterparts of ICAM 1 ( CD 54 ) , the molecules Mac 1 ( CD11b / CD18 ) and leukosialin ( CD 43 ) , and the principal ligand LFA 1 ( CD11a / CD18 ) . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
There were no significant differences , however , in the expression of CD 23 , CD 32 , Mac 1 and adhesion molecules ( ICAM 1 , leukocyte function associated antigen 1 alpha ( LFA 1 alpha ) , LFA 1 beta , very late antigen 4 ) on eosinophils of patients with strongyloidiasis positive for anti HTLV 1 antibodies in comparison with those negative for these antibodies . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of very late antigen 4 ( VLA 4 ) , lymphocyte function associated antigen 1 ( LFA 1 ) and macrophage antigen 1 ( Mac 1 ) on eosinophils from patients with eosinophilia was increased compared with those from healthy subjects . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The H 4 expression pattern and biochemical features , together with cross blocking , co capping , co modulation , and immunoprecipitation preclearing experiments showed that H 4 is different from other known co stimulatory molecules such as CD 69 , CD 2 , Ly 6 , CD 25 , OX 40 , Mac 1 and LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Human intercellular adhesion molecule 1 ( ICAM 1 ) plays an important role in immune responses as the major specific ligand for the beta 2 integrins LFA 1 and Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Flow cytometry analysis of the spleen cells removed at various times from M . intracellulare infected mice also indicated no change in the level of LFA 1 beta or MAC 1 , a finding comparable with that of the J774A . 1 cells . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In this study , we investigated the involvement of the adhesion molecules intercellular adhesion molecule 1 ( ICAM 1 ) , vascular cell adhesion molecule 1 ( VCAM 1 ) , very late activation antigen 4 ( VLA 4 ) , lymphocyte function associated antigen 1 ( LFA 1 ) and macrophage antigen 1 ( Mac 1 ) on eosinophil infiltration in the cutaneous late phase response ( LPR ) in OVA sensitized Balb / c mice by two approaches , immunostaining and inhibition assays with each monoclonal antibody . ^^^ Infiltrated eosinophils and mononuclear cells in the skin expressed Mac 1 ( eosinophils : 38 . 9 + / 1 . 55 % , mononuclear cells : 51 . 2 + / 2 . 15 % ) , LFA 1 ( eosinophils : 33 . 3 + / 0 . 95 % , mononuclear cells : 23 . 1 + / 1 . 07 % ) and VLA 4 ( eosinophils : 14 . 3 + / 1 . 6 % , mononuclear cells : 17 . 2 + / 1 . 38 % ) at 12 h . ^^^ On the other hand , pretreatment with anti mouse LFA 1 mAb or Mac 1 mAb did not significantly decrease the infiltration . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD 18 is a subunit for three beta 2 integrin molecules ( Mac 1 , p 150 , 95 , LFA 1 ) , which are expressed on the plasma membrane of neutrophils . ^^^ CD 18 is a subunit for three beta 2 integrin molecules ( Mac 1 , p 150 , 95 , LFA 1 ) , which are expressed on the plasma membrane of neutrophils . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In this study , we observed PAF induced up regulation of inducible adhesion molecules Mac 1 and LFA 1 beta on eosinophils of atopic patients compared with non atopic and normal subjects . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The sections were also stained immunohistochemically for the vascular endothelial adhesion molecules ICAM 1 , ELAM 1 ( E selectin ) , and VCAM 1 , and for the leukocyte ligands for ICAM 1 : LFA 1 ( CD11a / CD18 ) and Mac 1 ( CD11b / CD18 ) . ^^^ Infiltrating monocytes and lymphocytes expressed the LFA 1 ligand and infiltrating PMN expressed the MAC 1 ligand . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Inhibition and stimulation of LFA 1 and Mac 1 functions by antibodies against murine CD 18 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The transition to cell arrest involved both LFA 1 ( CD11a / CD18 ) and Mac 1 ( CD11b / CD18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
By recognizing a site distinct from that of beta 2 integrins Mac 1 or LFA 1 , fibrinogen binding to ICAM 1 may provide an alternative pathway of intercellular adhesion and / or modulate integrin dependent adherence during inflammation and vascular injury . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To elucidate the impaired neutrophil function in patients with chronic renal failure , we analyzed the expression of the adhesion molecules , LAM 1 , LFA 1 , Mac 1 , gp150 / 95 and phagocytosis activity of neutrophils in predialysis and hemodialysis patients by flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Migration of activated neutrophils into MEE was significantly inhibited by blocking surface expressed cell adhesion molecules ( CAM ) with anti CD11b ( Mac 1 alpha ) and anti CD 18 ( common beta 2 subunit ) antibodies ( P < 0 . 001 ) but not with anti CD11a ( LFA 1 alpha ) antibody . ^^^ In vitro regulation of neutrophil migration by beta 2 integrins ( LFA 1 and Mac 1 ) in patients with otitis media . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast to LFA 1 , Mac 1 appeared to recognize a CD 54 independent ligand constitutively expressed on the hepatocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
At the initial biopsy , there was no difference in the degree of glomerular C3c deposition , glomerular intercellular adhesion molecule ( ICAM ) 1 expression , or the numbers of cells bearing leukocyte function associated antigen 1 ( LFA 1 ) , Mac 1 , and ICAM 3 between the two groups . ^^^ At the follow up biopsy , the degree of glomerular C3c deposition , and the numbers of cells bearing LFA 1 , Mac 1 , and ICAM 3 , were significantly decreased only in group A ( P < 0 . 01 , P < 0 . 001 , P < 0 . 001 , and P < 0 . 01 , respectively ) . ^^^ Neither LFA 1 nor Mac 1 positive cells were positively correlated with ICAM 1 expression . ^^^ These results suggest that the glomerular leukocytes , infiltrating through Mac 1 / complement interaction , express ICAM 3 by themselves , and that LFA 1 / ICAM 3 interaction might participate in the glomerular aggregation of leukocytes in MPGN type 1 . ^^^ In this study , we could not conclude that LFA 1 / ICAM 1 or Mac 1 / ICAM 1 interaction was involved in the leukocyte accumulation in this disease . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Pretreatment of the A NK cells with monoclonal antibodies directed against CD 18 ( LFA 1 ) or CD49d ( VLA 4 ) resulted in a significant reduction in the number of binding cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The inflammatory reaction of the glomeruli of the kidneys was studied by immunohistochemical methods using 4 microm cryostat sections stained with specific monoclonal antibodies against neutrophils ( polymorphonuclear cells , PMNs ) and monocytes ( MOs ) , and against the adhesion molecules ICAM 1 and VCAM 1 on the endothelium , and LFA 1 , MAC 1 , and VLA 4 on the leukocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule 1 ( ICAM 1 , CD 54 ) is a member of the Ig superfamily and is a counterreceptor for the beta 2 integrins : lymphocyte function associated antigen 1 ( LFA 1 , CD11a / CD18 ) , complement receptor 1 ( MAC 1 , CD11b / CD18 ) , and p 150 , 95 ( CD11c / CD18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of intercellular adhesion molecule 1 ( CD 54 or ICAM 1 ) on epithelial cells during acute or chronic inflammation may favor the interaction between epithelial cells and leukocytes expressing the natural ligands of ICAM 1 , LFA 1 ( CD11a / CD18 ) , and Mac 1 ( CD11b / CD18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NIF specifically antagonized Mac 1 dependent adherence , but the peptide blocked neutrophil adherence that was dependent upon both Mac 1 and LFA 1 integrins . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The number of CD4+ T cells and macrophage antigen 1 ( Mac 1 [ + ] ) cells in the brain and spinal cord were not decreased by anti LFA 1 MAb treatment . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Using flow cytometry , high concentrations of ICAM 1 , VCAM 1 , and NCAM antigens were detected on undifferentiated ES cells , but their specific receptors , Mac 1 , LFA 1 , and VLA 4 , were not detected . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
These agents enhanced adhesion of PMN to human umbilical vein endothelial cells stimulated with tumor necrosis factor alpha ( TNF alpha ) , and this effect was also mediated by beta 2 integrins LFA 1 and Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Notably , antibodies directed against VLA 4 , other beta 2 integrins ( Mac 1 and p 150 ) , or other potential LFA 1 counterstructures that were expressed on the cell surface ( ICAM 1 and ICAM 3 ) did not block aggregation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Tethering of PMN on platelet ICAM 2 via LFA 1 ( alphaLbeta 2 ) was observed , which may facilitate the transition between rolling on selectins and Mac 1 dependent arrest . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Kinetics of the expression of LFA 1 alpha / CD11a , LFA 1 beta / CD18 , Mac 1 / CD11b , VLA 4 / CD49d , ICAM 1 / CD54 and L selectin / CD62L was determined on splenic CD4+ and CD8+ T cells and macrophages by flow cytometry . ^^^ In the spleen , a sustained increase in LFA 1 expression and a temporary increase at day 7 in the expression of VLA 4 , Mac 1 and ICAM 1 were detected on CD8+ T cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The degenerating nerves were invaded by Mac 1 , LFA 1 , and F4 / 80 positive macrophages ; significantly lower numbers of macrophages were present in ICAM 1 deficient nerves . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The present study was undertaken to determine whether polymorphonuclear neutrophils ( PMNs ) can contribute to hepatic ischemia reperfusion injury , and pretreatment with monoclonal antibodies ( mAbs ) to intercellular adhesion molecule 1 ( ICAM 1 ) , lymphocyte function associated antigen 1 ( LFA 1 ) , and CD 18 could improve energy metabolism and prolong the viability of the organ . ^^^ Monoclonal antibodies to ICAM 1 , LFA 1 , or CD 18 were injected intravenously 5 minutes before inducing ischemia . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast , the expression of FcRII , FcRIII , L selectin , LFA 1 and CD 18 on neutrophils was significantly reduced in the H MDS patients compared with the controls . ^^^ The L MDS neutrophils exhibited lower expressions of CR 1 , L selectin , LFA 1 and CD 18 than those of the controls . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Levels of L selectin , leukocyte functional antigen 1 ( LFA 1 ) , Mac 1 , and very late activation antigen 4 ( VLA 4 ) expression were determined on alphabeta and gammadelta T cells and monocytes by dual color immunofluorescent flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Cells infiltrating livers of IL 12 treated mice were primarily mononuclear leukocytes expressing LFA 1 , VLA 4 , MAC 1 , and CD 18 adhesion molecules but little L selectin . ^^^ Kupffer cells constitutively expressed LFA 1 and smaller amounts of MAC 1 , and high levels of ICAM 1 were constitutively expressed by liver sinusoidal lining cells , portal tract , and central vein endothelia . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Adhesion molecules such as ICAM 1 , Mac 1 , and LFA 1 may help regulate interactions of immune cells and inflammatory cells . ^^^ LFA 1 and Mac 1 were strongly expressed in these immune and inflammatory cells . ^^^ The increased expression of ICAM 1 is linked with massive infiltration of inflammatory cells that express LFA 1 and Mac 1 , and also with APCs that express HLA DR , suggesting that ICAM 1 exerts a key role in immuno inflammatory responses in gastric mucosa of patients with H . pylori associated gastritis . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Increase of cell attachment was dependent on lymphocyte function associated antigen 1 ( LFA 1 ) and on Mac 1 , since it could be blocked with antibodies against both respective integrin alpha chains . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
GM CSF induced adhesion was completely inhibited by incubation with monoclonal antibodies directed against the common beta 2 chain ( CD 18 ) of the LFA 1 , Mac 1 , p 150 , 95 complexes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
ICAM 1 binds to leukocyte function associated antigen ( LFA 1 ) or macrophage 1 antigen ( Mac 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Increased expression of neutrophil and monocyte adhesion molecules LFA 1 and Mac 1 and their ligand ICAM 1 and VLA 4 throughout the acute phase of myocardial infarction : possible implications for leukocyte aggregation and microvascular plugging . ^^^ METHODS : We measured the expression of neutrophil and monocyte lymphocyte function associated antigen 1 ( LFA 1 ) , Mac 1 , very late after activation antigen 4 ( VLA 4 ) and intercellular adhesion molecule 1 ( ICAM 1 ) by flow cytometry throughout the acute phase of acute myocardial infarction in 25 patients and 10 age matched control subjects . ^^^ The expression of LFA 1 , Mac 1 , VLA 4 and ICAM 1 on the monocyte cell membrane in patients with an acute myocardial infarction was increased compared with that in control subjects by 22 % ( on day 7 ) , 67 % , 13 % and 44 % ( all on day 4 ) , respectively ( all p < 0 . 001 ) . ^^^ In addition , the manifestation of increased density of LFA 1 and Mac 1 by activated leukocytes with monocytes also expressing ICAM 1 suggests that leukocytes may form microaggregates that could cause microvascular plugging . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule 1 ( ICAM 1 ) is an inducible glycoprotein that interacts with the leukocyte beta 2 integrins , LFA 1 and Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In the present study on idiopathic membranous glomerulonephritis ( MGN ) the expression of adhesion molecules ( ICAM 1 , VCAM 1 , PECAM 1 , E selectin , LFA 1 , Mac 1 ) was analyzed in different cellular compartments of the kidney using an indirect immunoperoxidase technique and monoclonal antibodies . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Here we investigated in parallel the role of beta 2 integrin family members , LFA 1 ( CD11a / CD18 ) and Mac 1 ( CD11b / CD18 ) on monocytes , and the immunoglobulin supergene family members , ICAM 1 and ICAM 2 on HSF and on human umbilical vein endothelial cells ( HUVEC ) , in monocyte migration through HSF and HUVEC monolayers . ^^^ Using function blocking monoclonal antibodies ( mAb ) , when both VLA 4 and VLA 5 on monocytes were blocked , treatment of monocytes with mAb to both LFA 1 and to Mac 1 completely inhibited monocyte migration across HSF barriers , although blocking either of these beta 2 integrins alone had no effect on migration , even when VLA 4 and VLA 5 were blocked . ^^^ This indicates that optimal beta 2 integrin dependent monocyte migration in synovial connective tissue may be mediated by either LFA 1 or Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Serial frozen sections of grafts and controls were stained by immunoperoxidase for rat MAC 1 , class 2 MHC , CD 2 , CD 4 , CD 8 , B cells , VLA 4 , LFA 1 , L selectin , ICAM 1 , and VCAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Experiments employing blocking antibodies to adhesion molecules demonstrated requirements for the beta 1 integrin VLA 4 , beta 2 integrins LFA 1 and Mac 1 , and L selection . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To address this phenomenon , we used the air pouch ( AP ) model in control and infected Swiss webster mice , analyzing the cellular , tissue response and local expression of adhesion molecules [ CD 18 ( beta ( 2 ) chain ) , CD 44 , ICAm 1 ( CD 54 ) , L selectin ( CD62L ) , CD49d ( alpha ( 4 ) chain ) , LFA 1 ( CD 11 alpha ) ] . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule 1 ( ICAM 1 ) is a ligand for the integrins lymphocyte function associated antigen 1 ( LFA 1 ) and complement receptor 3 ( Mac 1 ) , making it an important participant in many immune and inflammatory processes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
METHODS : To investigate the mechanisms of intraglomerular leukocyte infiltration in IgA nephropathy ( IgA N ) and membranoproliferative glomerulonephritis type 1 ( MPGN 1 ) , we immunohistochemically examined the intraglomerular expression of leukocyte function associated antigen 1 ( LFA 1 , CD11a / CD18 ) , macrophage 1 ( Mac 1 , CD11b / CD18 ) and intercellular adhesion molecule 1 ( ICAM 1 , CD 54 ) together with glomerular deposition of C3c and fibrinogen . ^^^ The LFA 1 / ICAM 1 pathway may play an important role in glomerular leukocyte infiltration in IgA N , while the Mac 1 / complement pathway may be important in MPGN 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Hydrodynamic shear shows distinct roles for LFA 1 and Mac 1 in neutrophil adhesion to intercellular adhesion molecule 1 . ^^^ Both LFA 1 and Mac 1 contributed equally to adhesion efficiency over the initial 30 seconds of stimulation , but adhesion was entirely Mac 1 dependent by 120 seconds . ^^^ We conclude that at low shear , neutrophil adhesion is modulated independently through either LFA 1 or Mac 1 , which initially contribute with equal efficiency , but differ over the duration of chemotactic stimulation . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LFA 1 , Mac 1 , CD 44 , ICAM 1 and P selectin were strongly expressed in the acute phase and to a lesser degree in the chronic phase of arthritis . ^^^ LFA 1 , Mac 1 , CD 44 , alpha 4 integrin , ICAM 1 and the selectins were found expressed on cells of the synovial infiltrate , LFA 1 , Mac 1 and ICAM 1 on the synovial lining layer , and VCAM 1 and P selectin on endothelial cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Surface bound platelets express ICAM 2 and GPIIbIIIa bound fibrinogen , which are ligands for LFA 1 and MAC 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Commercially available anti CD 18 ( beta 2 integrin , beta chain of LFA 1 , MAC 1 , and p 150 , 95 ) and LRTC 1 MAb immunoprecipitated proteins with identical mobilities on 1 D and 2 D SDS PAGE gels . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of the H 52 epitope on the beta 2 subunit is dependent on its interaction with the alpha subunits of the leukocyte integrins LFA 1 , Mac 1 and p 150 , 95 and the presence of Ca2+ . ^^^ In the presence of Ca2+ and Mg2+ , the H 52 epitope is expressed on the monomeric beta 2 subunit , the LFA 1 and Mac 1 heterodimers but not on p 150 , 95 , thus implying that this epitope is masked in p 150 , 95 . ^^^ However , expression of the H 52 epitope on Mac 1 , but not on LFA 1 , or the monomeric beta 2 subunit , is dependent on the presence of Ca2+ , thus suggesting that the chelation of Ca2+ causes a conformational change in Mac 1 which results in the loss of the epitope . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Characteristics of cation binding to the 1 domains of LFA 1 and MAC 1 . ^^^ The crystal structures of the 1 domains of integrins MAC 1 ( alphaM beta 2 ; CD11b / CD18 ) and LFA 1 ( alphaL beta 2 ; CD11a / CD18 ) show that a single conserved cation binding site is present in each protein . ^^^ Here we show that the purified recombinant 1 domain of LFA 1 ( alphaLI ) binds cations , but with significantly different characteristics compared with the 1 domain of MAC 1 ( alphaMI ) . ^^^ Antagonism of LFA 1 , but not MAC 1 , mediated cell adhesion by Ca2+ may be related to the Ca2+ binding activity of the LFA 1 1 domain . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition , in 19 cases the expression of adhesion molecules ( LFA 1 ( CD 18 ) , ICAM 1 ( CD 54 ) , alpha4beta1 integrin ( CD49d / CD29 ) , L selectin ( CD62L ) and CD 44 ) was studied . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
At relatively low shear rates ( 100 200 s ( 1 ) ) firm adhesion is mediated in equal measure by LFA 1 binding to ICAM 3 , and Mac 1 binding to an as yet undefined ligand . ^^^ In this report we used a mouse melanoma cell line expressing an estimated 700 , 000 ICAM 1 ( CD 54 ) to examine the relative roles of LFA 1 and Mac 1 over the kinetics of heterotypic cell adhesion in shear mixed suspensions . ^^^ A direct interaction between LFA 1 and ICAM 1 was preferred over the first minute of stimulation , whereas at later times adhesion was supported equally by Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Activated neutrophils aggregate in a shear field via bonding of L selectin to P selectin glycoprotein ligand 1 ( PSGL 1 ) followed by a more stable bonding of LFA 1 ( CD11a / CD18 ) to intercellular adhesion molecule 3 ( ICAM 3 ) and Mac 1 ( CD11b / CD18 ) to an unknown counter receptor . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Human PMNL migration in vitro across unstimulated human umbilical vein endothelial cells ( HUVEC ) , induced by C5a or IL 8 , was virtually all mediated by the CD 18 ( beta 2 ) integrins , LFA 1 and Mac 1 . ^^^ The integrins , LFA 1 and Mac 1 ( CD11 / CD18 ) , and VLA 4 mediated PMNL migration to arthritic joints . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Twenty atopic asthmatic ( AA ) subjects and nine controls were studied and the expression of lymphocyte function associated antigen 1 ( LFA 1 ; CD11a / CD18 ) , Mac 1 ( CD11b / CD18 ) and very late antigen 4 ( VLA 4 ; CD49d / CD29 ) on blood eosinophils was evaluated by specific monoclonal antibody ( Mab ) staining and flow cytometric analysis . ^^^ Compared with controls , eosinophils from AA showed increased expression of LFA 1 ( p < 0 . 005 ) , but not of Mac 1 or VLA 4 ( p > 0 . 1 ) . ^^^ In addition , LFA 1 expression correlated positively with blood eosinophil number ( r=0 . 792 , p < 0 . 05 ) , while no correlations were observed between Mac 1 or VLA 4 expression and blood eosinophil number . ^^^ The migration of eosinophils through human umbilical vein endothelial cells with or without anti LFA 1 , Mac 1 and VLA 4 blocking Mab was studied . ^^^ Cell migration was totally inhibited by preincubating eosinophils with anti LFA 1 ( p < 0 . 05 ) , while anti Mac 1 had no effect ( p > 0 . 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We investigated the expression of adhesion molecules in circulating neutrophils ( lymphocyte function associated antigen 1 [ LFA 1 ] , Mac 1 , and L selectin ) and endothelial cells ( soluble intercellular adhesion molecule 1 [ sICAM 1 ] ) in 23 patients with stable chronic obstructive pulmonary disease ( COPD ) , 18 subjects with exacerbated COPD , and 23 healthy volunteers . ^^^ Compared with control subjects , patients with stable COPD showed increased expression of Mac 1 ( p < 0 . 001 ) and lower levels of sICAM 1 ( p = 0 . 002 ) ; LFA 1 and L selectin expression was similar in patients and control subjects . ^^^ During exacerbations , compared with stable patients , the expression of Mac 1 and LFA 1 was reduced ( p < 0 . 001 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Cross linking of the LFA 1 ( CD11a / CD18 ) and MAC 1 ( CD11b / CD18 ) integrins on the surface of THP 1 monocytic cells induced the accumulation of tyrosine phosphoproteins . ^^^ In vitro kinase assays documented an increase in ERK 2 activity following both LFA 1 and MAC 1 cross linking . beta 2 Integrin cross linking also led to a marked increase in 4 h procoagulant activity ( PCA ) in THP 1 cells and purified human monocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta 2 integrins Mac 1 and LFA 1 . ^^^ This level of expression should be adequate for normal integrin function , but both the patient ' s Mac 1 on neutrophils and LFA 1 on T cells failed to bind ligands such as fibrinogen and intercellular adhesion molecule ( ICAM ) 1 , respectively , or to display a beta 2 integrin activation epitope after adhesion inducing stimuli . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Finally , in the skin both epidermal Langerhans cells ( LC ) and dermal DC are CD 8 ( ) DEC 205 ( high ) Mac 1 ( high ) , and do not express LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We evaluated the relative contribution of ICAM 1 and ICAM 2 , known ligands on endothelium for LFA 1 and Mac 1 , in spontaneous neutrophil ( PMN ) transendothelial migration ( TEM ) across IL 1 activated HUVEC monolayers or TEM induced by C5a or IL 8 across unstimulated HUVEC grown on polycarbonate filters . ^^^ In contrast , with IL 1 HUVEC , mAb to ICAM 1 significantly inhibited this LFA 1 independent TEM . mAb to Mac 1 alone partially inhibited TEM and , when combined with mAb to LFA 1 , migration was almost completely blocked with all TEM conditions tested . ^^^ The contribution of alternate ligands for Mac 1 in mediating Mac 1 dependent but ICAM 1 / 2 independent C5a induced TEM was examined using anti LFA 1 treated PMN and anti ICAM treated resting HUVEC . ^^^ The results indicate that : ( 1 ) LFA 1 mediates PMN TEM primarily by interaction with ICAM 1 and ICAM 2 ; ( 2 ) ICAM 2 may function in concert with ICAM 1 in this role , especially on unstimulated endothelium , and ( 3 ) Mac 1 on PMN also plays a major role in TEM and can utilize yet to be identified ligands distinct from ICAM 1 or 2 , especially on unstimulated endothelium . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Increased adhesion of TMM cells was impaired neither by antibodies to VLA 4 , LFA 1 , or Mac 1 nor by antibodies to their counter receptors VCAM 1 or ICAM 1 , suggesting that adhesion molecules distinct from VCAM 1 or ICAM 1 are involved in enhanced adhesiveness of the fibroblasts to myeloid leukemic cells . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of surface molecules involved in rolling ( CD62L , CD 15 ) and firm adhesion ( Mac 1 and LFA 1 ) to endothelial cells was assessed by flow cytometry , while the chemotactic response of PMN to IL 8 and to fMLP was investigated in a Boyden chamber assay . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of intercellular adhesion molecule 1 ( ICAM 1 ) by endothelial cells is important for the regulation of adhesion and transendothelial migration of a variety of leukocytes that express the integrins lymphocyte function associated antigen 1 ( LFA 1 ) and / or Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition to LFA 1 , neutrophils express the beta 2 integrin Mac 1 ( CD11b / CD18 ; CR 3 ) that apparently contains multiple sites that bind invading microbes directly or through surface fixed C 3 , resulting in activation of the phagocyte function . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To further elucidate the mechanism ( s ) involved in this process , we have used an in vitro transendothelial chemotaxis model . mAb neutralization studies performed in this system suggest that the integrins Mac 1 ( CD11b / 18 ) , VLA 4 ( alpha4beta1 ) and LFA 1 ( CD11a / 18 ) are involved in the transendothelial chemotaxis of eosinophils to eotaxin . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We show that CC chemokines induced a sustained increase in monocyte adhesion to intercellular adhesion molecule 1 that was mediated by Mac 1 ( alphaMbeta 2 ) but not lymphocyte function associated antigen 1 ( LFA 1 ; alphaLbeta 2 ) . ^^^ Differential kinetics for activation of Mac 1 ( sustained ) and LFA 1 ( transient ) avidity in response to stromal derived factor 1alpha were confirmed by expression of alphaM or alphaL in alphaL deficient Jurkat cells . ^^^ Coexpressing alphaM or chimeras in mutant Jurkat cells with a `` gain of function ' ' phenotype that results in constitutively active LFA 1 demonstrated that Mac 1 was not constitutively active , whereas constitutive activity was mediated via the alphaL cytoplasmic tail , implying the presence of distinct signaling pathways for LFA 1 and Mac 1 . ^^^ Transendothelial chemotaxis of monocytes in response to MCP 1 was dependent on LFA 1 ; however , Mac 1 was involved at MCP 1 concentrations stimulating its avidity , showing differential contributions of beta 2 integrins . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
ICAM 2 , a constitutively expressed endothelial ligand for beta 2 integrins LFA 1 and Mac 1 , is involved in leukocyte adhesion to resting endothelium and in transmigration in vitro , however its role in inflammation is unclear . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Infiltration of neutrophils and expression of MAC 1 , LFA 1 , VLA 4 seem to be under control of progesterone or estradiol . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Previous findings have shown that a peptide derived from the first Ig domain of ICAM 2 ( P 1 ) binds to LFA 1 ( CD11a / CD18 ) and Mac 1 ( CD11b / CD18 ) and activates leukocyte aggregation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In particular , attention has been drawn to the role exerted by those cytokine ( TNF alpha and IL 1 beta ) and adhesion molecules ( LFA 1 , Mac 1 , ICAM 1 ) that regulate interactions between leukocyte and endothelial cells leading to gastric microvessels occlusion and ischaemic / hypoxic endothelial epithelial cell damage . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CONCLUSIONS : These observations indicate that exposure of HT 29 cells to bile acids or ammonia induces CD11b / CD18 ( Mac 1 ) dependent but CD11a / CD18 ( LFA 1 ) independent neutrophil adhesion to intestinal epithelial cells , and ICAM 1 is unlikely involved in the interactions . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The trafficking of leukocytes through tissues is supported by an interaction between the beta 2 ( CD 18 ) integrins CD11a / CD18 ( LFA 1 ) and CD11b / CD18 ( Mac 1 ) and their ligand ICAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Neutralizing Abs against the beta 2 integrins , LFA 1 and Mac 1 , decreased IL 6 production by 40 and 50 % , respectively . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Acute thermal injury of rat skin resulted in a time dependent loss of L selectin and up regulation of Mac 1 ( CD11b / CD18 ) on blood neutrophils , with no changes in LFA 1 ( CD11a / CD18 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LFA 1 and Mac 1 expression or with impairment of polymorphonuclear leukocyte antibacterial activity . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Together these observations suggest that short exposure of HT 29 cells to TNF alpha and histamine induces CD11b / CD18 ( Mac 1 ) dependent but CD11a / CD18 ( LFA 1 ) independent neutrophil adhesion to intestinal epithelial cells , and ICAM 1 is not likely to be involved in the interactions . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
ICAM 1 binds to leukocyte function associated antigen ( LFA 1 ) or macrophage 1 antigen ( Mac 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To differentiate the unique and overlapping functions of LFA 1 and Mac 1 , LFA 1 deficient mice were developed by targeted homologous recombination in embryonic stem cells , and neutrophil function was compared in vitro and in vivo with Mac 1 deficient , CD 18 deficient , and wild type mice . ^^^ LFA 1 deficient mice exhibit leukocytosis but do not develop spontaneous infections , in contrast to CD 18 deficient mice . ^^^ After zymosan activated serum stimulation , LFA 1 deficient neutrophils demonstrated activation , evidenced by up regulation of surface Mac 1 , but did not show increased adhesion to purified ICAM 1 or endothelial cells , similar to CD 18 deficient neutrophils . ^^^ Evaluation of the strength of adhesion through LFA 1 , Mac 1 , and CD 18 indicated a marked reduction in firm attachment , with increasing shear stress in LFA 1 deficient neutrophils , similar to CD 18 deficient neutrophils , and only a modest reduction in Mac 1 deficient neutrophils . ^^^ Leukocyte influx in a subcutaneous air pouch in response to TNF alpha was reduced by 67 % and 59 % in LFA 1 and CD 18 deficient mice but increased by 198 % in Mac 1 deficient mice . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The enhanced TEM was inhibited by monoclonal antibodies ( mAb ) to LFA 1 , but not by mAb to Mac 1 or to VLA 4 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The first is to allow leukocyte infiltration of respiratory mucosa , since they express LFA 1 and Mac 1 , which are ligands of ICAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
As evident from antibody blocking experiments , PF 4 induced adhesion involved PMN expressed L selectin as well as leukocyte function associated molecule 1 ( LFA 1 ) , whereas IL 8 involved MAC 1 . ^^^ Because blocking antibodies to LFA 1 but not to L selectin or MAC 1 abrogated PF 4 dependent marker exocytosis from PMN , the costimulatory signal provided by EC appears to be elicited through cell cell contact via LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD 24 and CD 18 were found to co localize in rafts and cross linking with CTx lead to enhanced LFA 1 clustering . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
ICAM 1 ( CD 54 ) , the ligand for LFA 1 and Mac 1 , is up regulated during inflammatory reaction on the activated vascular endothelium . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
ICAM 1 interactions with the beta 2 integrins CD11a / CD18 ( LFA 1 ) and CD11b / CD18 ( MAC 1 ) on the surface of leukocytes are important for their transendothelial migration to sites of inflammation and their function as costimulatory molecules for T cell activation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
BACKGROUND : Lymphocyte function associate 1 ( LFA 1 ) , macrophage antigen 1 ( Mac 1 ) , and very late activation antigen 4 ( VLA 4 ) are involved in the infiltration of leukocytes into the tissues . ^^^ METHODS : We evaluated by immunocytochemistry the expression of VLA 4 , LFA 1 , and Mac 1 and their relationship with inflammatory cells and severity of disease in the induced sputum of 20 mild to moderate atopic asthmatic subjects and in 8 healthy subjects . ^^^ In contrast , LFA 1 and Mac 1 cellular expressions do not differ between asthmatic and control subjects and are not related to any specific cell type . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Adhesion molecules identified were intercellular adhesion molecule 1 ( ICAM 1 ) , ICAM 2 , ICAM 3 , vascular cell adhesion molecule 1 ( VCAM 1 ) , platelet endothelial cell adhesion molecule 1 ( PECAM 1 ) , E selectin , P selectin , L selectin , lymphocyte function associated antigen 1 ( LFA 1 ) , very late activation antigen 4 ( VLA 4 ) , Mac 1 ( CD18 / CD11b ) , and gp 150 , 95 ( CD18 / CD11c ) . ^^^ Concurrent analysis of leukocyte receptors indicated a preferential use of VLA 4 / VCAM 1 and LFA 1 / ICAM 1 at the adventitia and Mac 1 / ICAM 1 at the intima media junction . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
There is some disagreement in the literature over the respective roles of conformational changes in the 1 domain and of divalent cations ( Mg ( 2+ ) , Mn ( 2+ ) ) in the activation of LFA 1 for intercellular adhesion molecule binding . 10 ray crystallographic structures of the 1 domains of LFA 1 and Mac 1 in the presence and absence of cations show structural differences in the C terminal alpha helix ; this change was proposed to represent the active and inactive conformations of the 1 domain . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In dermal inflammation in the arthritic rats , LFA 1 accounted for most ( 69 % ) of the selectin independent monocyte migration to the chemoattractant C5a ( desArg ) ( zymosan activated serum ) , whereas LFA 1 and Mac 1 both contributed to selectin independent neutrophil recruitment to C5a ( desArg ) . alpha ( 4 ) integrin and P selectin in concert mediated monocyte recruitment to lipopolysaccharide and IFN gamma lesions ( 81 % ) . ^^^ Thus : ( 1 ) either alpha ( 4 ) or LFA 1 can mediate monocyte migration to arthritic joints in the absence of selectin function and alpha ( 4 ) together with P selectin is particularly important ; ( 2 ) LFA 1 is the predominant mechanism of selectin independent migration of neutrophils to inflamed joints ; and ( 3 ) in arthritic rats , selectin independent migration of monocytes and neutrophils to dermal inflammation is mediated by alpha ( 4 ) or LFA 1 or both LFA 1 and Mac 1 , depending on the leukocyte type , and inflammatory stimulus . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
These results indicate that canine neutrophils may utilize both LFA 1 and Mac 1 to adhere to adult cardiac myocytes , with LFA 1 triggered by a PAF like activity induced in myocytes by H ( 2 ) O ( 2 ) . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In the presence of different concentrations of budesonide ( 0 . 1 100 nM ) , we tested : a ) eosinophil migration induced by C5a through HBEC monolayers ; b ) ICAM 1 expression on HBECs , stimulated with C5a and c ) LFA 1 and Mac 1 expression on eosinophils , stimulated with C5a or with ah CD 23 mabs plus GM CSF . ^^^ Preincubation of the cells with different concentrations of budesonide was also effective in down regulating the C5a induced ICAM 1 expression on HBECs and the ah CD 23 and GM CSF induced LFA 1 and Mac 1 expression on eosinophils . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Cell arrest was dependent on application of shear and activation of Mac 1 and LFA 1 to bind ICAM 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We deleted the 1 domain from the integrin alpha ( M ) and alpha ( L ) subunits to give 1 less Mac 1 and lymphocyte function associated antigen 1 ( LFA 1 ) , respectively . ^^^ Binding to iC3b and factor 10 by 1 less Mac 1 was inhibited by the function blocking antibody CBRM1 / 32 , which binds to the beta propeller domain of the alpha ( M ) subunit . 1 less LFA 1 did not bind its ligands intercellular adhesion molecule 1 and 3 . ^^^ Thus , the 1 domain is not essential for the folding , heterodimer formation , and surface expression of Mac 1 and LFA 1 and is required for binding to some ligands , but not others . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Adhesion molecules LFA 1 ( CD 11a ) , Mac 1 ( CD 11b ) of t lymphocytes in bronchoalveolar lavage fluid and blood in patients with chronic respiratory tract disease ] . ^^^ The aim of our study was to assess the percentage of T lymphocytes expressing LFA 1 , Mac 1 and ICAM 1 in bronchoalveolar fluid ( BALF ) and blood of patients with sarcoidosis , atopic bronchial asthma and chronic bronchitis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The role of LFA 1 , Mac 1 , ICAM 1 and Ia in the induction of Th 2 type of immune response in spleen during murine syngeneic pregnancy . ^^^ Immunochemical localization of ICAM 1 , LFA 1 , Mac 1 and Ia in spleen have been carried out at different stages of pregnancy and formation of cell clusters and natural cell adhesion assay with splenocytes were carried out on day 1 ( D 1 ) pregnancy and compared with control . ^^^ Upregulation of ICAM 1 , LFA 1 , Mac 1 and Ia was observed during early pregnancy . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
RESULTS : Peripheral blood eosinophils constitutively expressed low levels of ICAM 1 and ICAM 2 ( < 10 FMI ) , moderate levels ( 10 50 FMI ) of CD 29 and L selectin , and high levels ( > 50 FMI ) of ICAM 3 , LFA 1 , and Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Cell adhesion was mediated via beta ( 2 ) integrin ( LFA 1 and Mac 1 ) activation : induced adhesion to HUVECs was inhibited by blocking mAbs anti CD 18 ( 70 % 90 % ) , anti CD11a ( 50 % 60 % ) , or anti CD11b ( 60 % 70 % ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Addition of anti E cadherin mAb or mAbs to any of the constitutively expressed adhesion molecule ( CD 99 , CD 31 , LFA 1 , or CD 18 ) to TGF beta 1 supplemented progenitor cell cultures inhibits LC precursor cell cluster formation , and this effect is , with the exception of anti E cadherin mAb , associated with inhibition of LC generation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To isolate LFA 1 / ICAM 1 interactions from Mac 1 / ICAM 1 interactions , full length chimeric ICAM 1 was developed and expressed in L cells with domains 1 and 2 from canine ICAM 1 and domains 3 5 from human ICAM 1 ( C 1 , 2 ; H 3 5 ) . ^^^ The following seven experimental conditions distinguished LFA 1 dependent H2O2 production from Mac 1 dependent production : It did not require exogenous chemotactic stimulation ; H2O2 release was more rapid , but the amount released was < 40 % of that mediated by Mac 1 adhesion ; it was inhibited by anti CD11a and anti ICAM 1 antibodies ; in contrast to that mediated by Mac 1 , it was not inhibited by anti CD11b antibody , neutrophil inhibitory factor ( NIF ) , or cytochalasin B or H 7 . ^^^ Thus , canine neutrophils seem to be able to utilize two members of the beta 2 integrin family to interact with ICAM 1 and signal H2O2 production , with LFA 1 at an early stage without prior chemotactic stimulation and Mac 1 at a later stage requiring chemotactic stimulation . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
METHODS AND RESULTS : PECAM 1 , CD 34 , ICAM 1 , VCAM 1 , VLA 4 , P and E selectin , the macrophage antigens Ki M1P and Mac 1 , and lymphocyte function antigen LFA 1 were identified immunohistochemically . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Leukocyte adhesion deficiency 1 ( LAD 1 ) is the result of mutations in the beta 2 subunit of the CD11 / CD18 integrins , LFA 1 , Mac 1 , p 150 , 95 and alphadbeta 2 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The intercellular adhesion molecule 1 ( ICAM 1 , CD 54 ) serves as a counter receptor for the beta 2 integrins , LFA 1 and Mac 1 , which are expressed on leukocytes . ^^^ This adhesion was inhibited by antibodies specific for either ICAM 1 or LFA 1 / Mac 1 , suggesting a role for these molecules in adhesion . ^^^ Nonetheless , within each cell line , blocking of ICAM 1 or LFA 1 / Mac 1 reduced LAK cell killing , suggesting that ICAM 1 is involved in mediating this killing . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Effect of integrin beta 2 subunit truncations on LFA 1 ( CD11a / CD18 ) and Mac 1 ( CD11b / CD18 ) assembly , surface expression , and function . ^^^ LFA 1 ( CD11a / CD18 ) and Mac 1 ( CD11b / CD18 ) are members of the beta 2 integrins involved in leukocyte function during immune and inflammatory responses . ^^^ We aimed to determine a minimized beta 2 subunit that forms functional LFA 1 and Mac 1 . ^^^ However , only the beta 2 variants terminating after Q 444 promote cell surface expression of LFA 1 and Mac 1 . ^^^ Thus , the major cysteine rich region and the three highly conserved cysteine residues at positions 445 , 447 , and 449 of the beta 2 subunit are not required for LFA 1 and Mac 1 surface expression . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This enables ICAM 1s to bind leukocyte integrin receptors such as LFA 1 ( CDI1a / CD18 ) and Mac 1 ( CDI1b / CD18 ) and therefore provide adaptive changes in the adhesion process between circulating cells and the endothelium . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The number of invading macrophages was determined by immunocytochemistry for three typical macrophage antigens ( F4 / 80 , Mac 1 , LFA 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Flow cytometric analysis of the 3 lines revealed constitutive surface molecule expression of Mac 1 , Mac 2 , F4 / 80 , LFA 1 , B 7 1 , B 7 2 , H2Kb , H2Db , and macrophage scavenger receptor , consistent with macrophage / monocyte lineages . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The leukocyte integrins LFA 1 and Mac 1 bind to endothelial intercellular adhesion molecule 1 ( ICAM 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Recent evidence is reviewed in support of the concept that integrin ( Mac 1 and LFA 1 ) activation results from signaling that occurs through selectin binding , chemotactic factor stimulation , and , possibly , LFA 1 binding . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The effect of antihuman CD 23 Mabs on : 1 ) eosinophil migration through human umbilical vein endothelial cells ( HUVECs ) ; and 2 ) eosinophil expression of the adhesion molecules leukocyte function associated antigen 1 ( LFA 1 , CD11a / CD18 ) , macrophage antigen 1 ( Mac 1 , CD11b / CD18 ) and very late activation antigen 1 ( VLA 4 , CD49d / CD29 ) was evaluated by specific Mab staining and flow cytometric analysis . ^^^ As compared to controls , freshly isolated eosinophils from atopic individuals showed enhanced migration through HUVECs ( p < 0 . 05 ) and increased LFA 1 expression ( p < 0 . 01 ) , but similar Mac 1 and VLA 4 expression ( p > 0 . 1 for both ) . ^^^ Similarly , incubation of the cells with antihuman CD 23 Mabs induced dose dependent upregulation of LFA 1 and Mac 1 expression , whereas no changes in VLA 4 expression were observed ( p > 0 . 1 ) . ^^^ Finally , the enhanced eosinophil migration induced by antihuman CD 23 Mab stimulation was significantly inhibited by antihuman LFA 1 ( 84+ / 14 % ( mean+ / SEM ) ; p < 0 . 01 ) and VLA 4 Mabs ( 47+ / 15 % ; p < 0 . 05 ) but not by antihuman Mac 1 Mabs ( p > 0 . 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
OBJECTIVE : To study the expression of L selectin , Mac 1 , LFA 1 on CML progenitor cells in relation to CML progression and therapeutic effect . ^^^ METHODS : The expression of adhesion molecules ( LFA 1 , Mac 1 , L selectin ) on bone marrow CD34+ cells from 34 CML patients were analyzed by three color flow cytometry . ^^^ IFN alpha and allo BMT restore the expression of Mac 1 , L selectin and LFA 1 to normal on CML CD34+ cells . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The use of lymphocyte function associated antigen ( LFA ) 1 deficient mice to determine the role of LFA 1 , Mac 1 , and alpha 4 integrin in the inflammatory response of neutrophils . ^^^ Here we use LFA 1 ( / ) mice , function blocking monoclonal antibodies , and intravital microscopy to investigate the roles of LFA 1 , Mac 1 , and alpha 4 integrins in neutrophil recruitment in vivo . ^^^ Blocking Mac 1 in the presence of LFA 1 significantly reduces emigration , suggesting cooperation between these two integrins . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Binding of a novel CD 18 activation epitope mAb to LFA 1 in response to soluble ICAM 1 binding was also blocked by inhibitory and was enhanced by activating IDAS mutations . ^^^ IDAS can control the affinity state of LFA 1 with concomitant 1 domain and CD 18 conformational changes . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We found that antibodies against VCAM 1 ( CD 106 ) , VLA 4 ( CD49d / CD29 ) , ICAM 1 ( CD 54 ) , and LFA 1 ( CD11a / CD18 ) did not influence the increased number of antigen specific T cells in the CSF However , upon intravenous ( i . v . ) injection , anti PECAM 1 ( CD 31 ) antibody or PECAM Ig chimeric molecule inhibited the trafficking of alpha / beta TCR+ Vbeta3+ Mac 1 cells into the CNS . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Blood samples taken 24 h preoperatively from 49 patients ( 3 18 years old ) were stained with monoclonal antibodies for adhesion molecules ( ICAM 1 , LFA 1 , Mac 1 ) or constitutive / activation markers ( CD 4 , CD 14 , CD 16 , CD 25 , CD 54 , CD 69 , HLA DR ) and measured on a microbead calibrated FCM . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Our results indicate that LktA induces tyrosine phosphorylation ( TP ) of the CD 18 tail of LFA 1 in bovine leukocytes . ^^^ The DeltaLktA mutant does not induce TP of the CD 18 tail , albeit binding to bovine LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The cecal peritoneum 24 hr after perforation was stained with specific antibodies against LFA 1 , Mac 1 , VLA 4 , ICAM 1 , VCAM 1 , and fibronectin diluted with cold University of Wisconsin ( UW ) solution in conjunction with immuno gold labeling . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Effects of IL 8 , Gro alpha , and LTB ( 4 ) on the adhesive kinetics of LFA 1 and Mac 1 on human neutrophils . ^^^ LFA 1 ( CD11a / CD18 ) appears to be more important than Mac 1 ( CD11b / CD18 ) in neutrophil emigration at inflammatory sites , but little is known of the relative binding characteristics of these two integrins under conditions thought to regulate firm adhesion . ^^^ The present study examined the effect of chemoattractants on the kinetics of LFA 1 and Mac 1 adhesion in human neutrophils . ^^^ Using well characterized monoclonal antibodies , we showed that activation of LFA 1 and Mac 1 by Gro alpha was completely blocked by anti CXC chemokine receptor R 2 , but activation of these integrins by interleukin 8 was most effectively blocked by anti CXC chemokine receptor R 1 . ^^^ The topographical distribution of beads also reflected significant differences between LFA 1 and Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In a purified system , HK and HKa inhibited the binding of soluble fibrinogen and ICAM 1 to immobilized Mac 1 , but not the binding of ICAM 1 to immobilized LFA 1 ( CD11a / CD18 , alphaLbeta 2 ) . ^^^ Accordingly , HK , HKa , and domain 5 inhibited the adhesion of Mac 1 but not LFA 1 transfected K 562 human erythroleukemic cells to ICAM 1 . ^^^ Taken together , HKa ( and particularly domain 5 ) specifically interacts with Mac 1 but not with LFA 1 , thereby blocking Mac 1 dependent leukocyte adhesion to fibrinogen and endothelial cells in vitro and in vivo and serving as a novel endogenous regulator of leukocyte recruitment into the inflamed tissue . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We developed a panel of mAbs that recognize activation epitopes on the CD 18 subunit , and show that stimulation of T lymphocytes appears to be accompanied by a conformational change in a subpopulation of LFA 1 that does not require ligand binding . ^^^ One activation epitope Ab binds to a site on CD 18 distinct from that of the blocking Abs , indicating that the blocking Abs suppress a conformational change in LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Subsequent challenge with LPS i . p . was associated with upregulation of Mac 1 and ICAM 1 on PMN , but not of VLA 4 or LFA 1 ( FACS analysis ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Data are now presented to show that , in addition to the LFA 1 and other integrin mediated leucocyte adhesions , cistifolin inhibits the Mac 1 ( CD11b / CD18 ) dependent monocyte adhesion to fibrinogen in a concentration dependent manner . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The average rolling velocities in venules were elevated in LFA 1 ( / ) mice ( 11 . 0 + / 0 . 7 microm / s ) and Mac 1 ( / ) mice ( 10 . 1 + / 1 . 1 microm / s ) compared to wild type mice ( 4 . 8 + / 0 . 3 microm / s ; P < . 05 ) , but were lower than in CD 18 ( / ) mice ( 28 . 5 + / 2 . 1 microm / s ) . ^^^ When both LFA 1 and Mac 1 were absent or blocked , rolling velocity became dependent on shear rate and approached that of CD 18 ( / ) mice . ^^^ In addition , leukocyte adhesion efficiency was decreased in LFA 1 ( / ) mice to near CD 18 ( / ) levels , but decreased only slightly in Mac 1 ( / ) mice . ^^^ Control of leukocyte rolling velocity in TNF alpha induced inflammation by LFA 1 and Mac 1 . ^^^ In this study , mice that are deficient for either one of the beta ( 2 ) integrins , alpha ( L ) beta ( 2 ) ( LFA 1 ) or alpha ( M ) beta ( 2 ) ( Mac 1 ) , were used to determine which of the beta ( 2 ) integrins are responsible for slowing rolling leukocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
TNF alpha stimulation increased the occurrence of adhesion molecules for neutrophil surface , lymphocyte function associated antigen 1 ( LFA 1 ) , and macrophage antigen 1 ( Mac 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule 1 ( ICAM 1 ) was up regulated by p 43 and mediated p 43 induced cell cell adhesion via the interaction with LFA 1 or Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A conformational switch in the 1 domain allosteric site ( IDAS ) and in CD 18 regulates LFA 1 affinity for endothelial ligands including intercellular adhesion molecule 1 ( ICAM 1 ) . ^^^ This was accompanied by a rapid redistribution of active LFA 1 , but not Mac 1 , into membrane patches , a necessary component for optimum adhesion efficiency . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
MATERIAL / METHODS : 140 EMBs from dilated cardiomyopathy ( DCM ) patients and 14 autopsy heart samples ( controls ) were immunostained for T lymphocytes ( CD 2 , CD 3 , CD 4 , CD 8 ) , beta ( 2 ) integrin+ infiltrates ( CD 18 , LFA 1 , Mac 1 ) and CAMs ( immunoglobulin superfamily : ICAM 1 , HLA class 1 , HLA DR , VCAM 1 , CD 58 ; selectins : CD62E and CD62P ; and the beta ( 1 ) integrin chain CD 29 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Inhibitory effect of olopatadine on antigen induced eosinophil infiltration and the LFA 1 and Mac 1 expression in eosinophils . ^^^ Olopatadine dose dependently repressed the IL 5 induced expressions of CD11a / CD18 ( LFA 1 ) and CD11b / CD18 ( Mac 1 ) on rat peritoneal eosinophils . ^^^ These results suggest that olopatadine may inhibit antigen induced eosinophil infiltration through repression of LFA 1 and Mac 1 expression . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
When monoclonal antibodies to mice VCAM 1 , CD11b or CD 18 were added separately to the co culture system , the number of TRAP positive cells that were generated from LFA 1 deficient mice was 20 30 % smaller than that generated from wild type mice . ^^^ The formation of TRAP positive cells from both LFA 1 deficient and wild type mice was especially inhibited by anti CD 18 antibody , in comparison to the addition of normal IgG serum . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monocyte and neutrophil expression of adhesion molecules Mac 1 , LFA 1 and 3 , ICAM 1 , and VLA 4 were measured at 0 , 120 , and 240 minutes by using laser flow cytometry . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Histomorphological evaluation of the vessels was performed , and endothelial expression of ICAM 1 , VCAM 1 , and E selectin was also evaluated , as well as distribution of LFA 1 , Mac 1 , VLA 4 , RM3 / 1 , 27E10 , and 25F9 bearing cells in the subepithelial tissue . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This heterophilic interaction was specifically attributed to a direct interaction of JAM 3 with the beta 2 integrin Mac 1 and to a lower extent with p150 . 95 ( alphaXbeta 2 , CD11c / CD18 ) but not with LFA 1 ( alphaLbeta 2 , CD11a / CD18 ) or with beta 1 integrins . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The study of humans with the beta 2 deficiency syndrome termed leukocyte adhesion deficiency ( LAD ) 1 and analysis of LFA 1 null mice has given further insight into integrin activation mechanisms and the in vivo roles of LFA 1 and other leukocyte integrins . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
METHODS : Blood eosinophils were isolated from seven atopic asthmatic patients and seven control subjects and the `` at baseline ' ' expression of lymphocyte function associated antigen 1 ( LFA 1 ) , macrophage antigen 1 ( Mac 1 ) and very late antigen 4 ( VLA 4 ) was assessed by monoclonal antibody staining and flow cytometry analysis . ^^^ Asthmatic patients underwent allergen challenge and the expression of LFA 1 , Mac 1 and VLA 4 by blood eosinophils was again evaluated 3 h and 24 h after allergen challenge . ^^^ RESULTS : As compared to controls , eosinophils from atopics showed at baseline enhanced LFA 1 expression ( P=0 . 0012 ) , but similar Mac 1 or VLA 4 expression ( P > 0 . 1 , each comparison ) . ^^^ Allergen challenge was also followed by a significant decrease in LFA 1 expression by eosinophils , at 3 h ( P=0 . 002 ) and at 24 h ( P=0 . 038 ) , while no changes in Mac 1 and VLA 4 were observed . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of the following cell adhesion molecules , their beta 1 and beta 2 integrin ligands and the cytokine tumour necrosis factor alpha ( TNF alpha ) was investigated by light and electron microscope immunohistochemistry in the liver tissue in 20 patients with colorectal and gastric cancer also presenting with liver metastases : intercellular adhesion molecule 1 ( ICAM 1 ) , vascular endothelial adhesion molecule 1 ( VCAM 1 ) , E selectin , leucocyte function associated antigen 1 ( LFA 1 ) , macrophage antigen 1 ( Mac 1 ) , and very late antigen 4 ( VLA 4 ) . ^^^ Tumour infiltrating host cells sowing positive immunoreactivity for ICAM 1 , VCAM 1 , LFA 1 , Mac 1 , and VLA 4 were located mainly at the boundary between liver parenchyma and the metastasis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Finally , end target chemoattractant responses were predominantly Mac 1 dependent , whereas nondominant chemoattractants used primarily LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of uPAR correlated with activation of beta ( 2 ) integrins lymphocyte function associated antigen 1 ( LFA 1 ) and macrophage antigen 1 ( Mac 1 ) , measured by using monoclonal antibodies ( mAbs ) 24 and CBRM1 / 5 . ^^^ Excessive adhesion of MNCs to HUVECs was inhibited by mAbs anti CD 18 ( 84 % ) , anti CD11a ( 51 % ) , and anti CD11b ( 57 % ) , indicating a major contribution of LFA 1 and Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To gain a profound insight into the underlying mechanisms , we phenotypically characterized pan leukocytes ( CD 18 ) , naive T lymphocytes ( CD 3 , CD 2 , CD 4 , CD 8 ) , activated lymphocytes ( LFA 1 , LFA 3 , VLA 4 , ICAM 1 , CD 69 , CD45R0 ) , macrophages ( Mac 1 , 27E10 ) , B lymphocytes ( CD 19 ) and NK cells ( CD 57 ) in DCM and control hearts . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
RESULTS : Specific cation dependent binding of lymphocytes to bronchial endothelium was observed which was significantly inhibited by antibodies against P selectin , PSGL 1 , L selectin , LFA 1 , ICAM 1 and ICAM 2 but not E selectin , VLA 4 , VCAM 1 or Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Leukocyte integrins LFA 1 , Mac 1 , and VLA 4 were preferentially localized to microvilli and ruffles of macrophages and lymphocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
HDACI induced homotypic aggregation was blocked by exposure to a monoclonal antibody specific for the beta chain ( CD 18 ) of an ICAM 1 ligand , LFA 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Therefore , the role of the adhesion molecules intercellular adhesion molecule 1 ( ICAM 1 ) , LECAM 1 , CD 18 , leukocyte function associated antigen 1 ( LFA 1 ) and platelet endothelial cell adhesion molecule 1 ( PECAM 1 ) on the BjV induced neutrophil accumulation and the correlation with release of LTB 4 , TXA 2 , tumor necrosis factor alpha , interleukin ( IL ) 1 and IL 6 have been investigated . ^^^ This results suggest that ICAM 1 , LECAM 1 , LFA 1 and PECAM 1 , but not CD 18 , adhesion molecules are involved in the recruitment of neutrophils into the inflammatory site induced by BjV . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
This entry is facilitated by the up regulation of VCAM 1 and ICAM 1 on HBMECs and a corresponding increase of LFA 1 , VLA 4 , and MAC 1 on monocytes . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
All starches regulate the expression of adhesion molecules LFA 1 and ICAM 1 , as well as receptor Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Monocytes migrate in the first 2 hours of inflammation making use of alpha4beta1 but not of Mac 1 or lymphocyte function associated antigen 1 ( LFA 1 ) integrins . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
IL 8 and T lymphocytes expressing adhesion molecules LFA 1 ( CD11a / CD18 ) , Mac 1 ( CD11b / CD18 ) Lsel in lower respiratory tract obstructive disease ] . ^^^ This study evaluated the concentration of IL 8 and count of T lymphocytes expressing adhesion molecules LFA 1 , Mac 1 , Lsel and their correlation in patients with asthma and COPD in periods of exacerbation and clinical improvement ( after seven days of anti inflammatory treatment ) . ^^^ The significant correlation observed in COPD patients between IL 8 concentration and counts of T cells expressing LFA 1 ( r = 0 . 44 ) , Mac 1 ( r = 0 . 49 ) , Lsel ( r = 0 . 42 ) in exacerbation period suggest a chemotactic influence of IL 8 on T lymphocytes . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Expression of the integrins LFA 1 , VLA 4 and Mac 1 and of members of the immunoglobulin superfamily of adhesion molecules ICAM 1 and VCAM 1 was suppressed in the central nervous system ( CNS ) following rEPF treatment . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In contrast , levels of beta ( 2 ) integrins ( e . g . , LFA 1 and Mac 1 ) , the molecules that would be necessary for C 8161 stable adhesion to the endothelium substrate , were found to be very low on these melanoma cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CTLs correlated with all endothelial CAMs markers studied ( P < 0 . 01 ) , the adhesion related phenotypes of infiltrates ( LFA 1 , VLA 4 , CD 18 ) and CD57+ NK cells ( P < 0 . 02 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Platelet activating factor ( PAF ) induced neutrophil lung sequestration may require cell surface adhesion molecules ( macrophage 1 antigen ( MAC 1 ) and lymphocyte function associated antigen 1 ( LFA 1 ) ) . ^^^ MAC 1 and LFA 1 expression were assessed by immunocytochemistry , and leukotriene B 4 ( LTB 4 ) was measured by enzyme immunoassay in induced sputum supernatants . ^^^ Compared with baseline and L PAF , PAF decreased the percentages of MAC 1 and LFA 1 positive neutrophils in PB at 5 min , but increased the percentages of MAC 1 and LFA 1 in neutrophil induced sputum . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
It was concluded that ( 1 ) the portion of the CD 18 stalk region deleted in mut 1 is critical for beta ( 2 ) integrin heterodimer expression but the portion of the cytoplasmic domain truncated in mut 2 is not ; and ( 2 ) the mut 2 cytoplasmic domain truncation impairs binding function of LFA 1 but not of Mac 1 . ^^^ Lymphocyte function associated antigen 1 ( LFA 1 ) and macrophage antigen 1 ( Mac 1 ) containing the mut 1 beta ( 2 ) subunit were expressed at very low levels compared with wild type ( wt ) beta ( 2 ) . ^^^ Mac 1 and LFA 1 expression with the mut 2 beta ( 2 ) subunit were equivalent to results with wt beta ( 2 ) . ^^^ Studies with the patient ' s neutrophils ( PMNs ) were consistent with functional impairment of LFA 1 but not of Mac 1 . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In addition , the level of ICAM 1 expression on sinusoidal endothelial cells greatly increased from 8 h after exposure to endotoxin , and these cells were adhered to neutrophils that expressed both LFA 1 and Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Lymphocyte function associated antigen 1 ( LFA 1 ) , macrophage 1 molecule ( Mac 1 ) and very late appearing antigen 4 ( VLA 4 ) , all ligands of ICAM 1 and VCAM 1 , were present on the transmigrated neutrophils and macrophages . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In vitro , RAGE dependent leukocyte adhesion to endothelial cells was mediated by a direct interaction of RAGE with the beta 2 integrin Mac 1 and , to a lower extent , with p 150 , 95 but not with LFA 1 or with beta 1 integrins . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Mac 1 , but not LFA 1 , uses intercellular adhesion molecule 1 to mediate slow leukocyte rolling in TNF alpha induced inflammation . ^^^ We have previously shown that Mac 1 and LFA 1 play a cooperative role in slow leukocyte rolling in inflamed vessels , and that , although both have a role in leukocyte adhesion , the contribution from LFA 1 exceeds that of Mac 1 . ^^^ In this study , we used mice deficient in ICAM 1 ( ICAM 1 ( null ) ) to study the function of ICAM 1 as an endothelial ligand for Mac 1 and LFA 1 . ^^^ Similarly , leukocyte adhesion efficiency in ICAM 1 ( null ) mice ( 0 . 11 + / 0 . 01 mm ) was similar to that in Mac 1 ( / ) ( 0 . 12 + / 0 . 03 mm ) mice but significantly increased compared with that in LFA 1 ( / ) ( 0 . 08 + / 0 . 01 mm ) mice and significantly reduced from that in wild type ( 0 . 26 + / 0 . 04 mm ) . ^^^ We conclude that endothelial ICAM 1 is the main ligand responsible for slow leukocyte rolling mediated by Mac 1 , but not LFA 1 . . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
JAMs associate through their extracellular domains with the leukocyte beta 2 integrins LFA 1 and Mac 1 as well as with the beta 1 integrin alpha4beta1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We examined the expression and dynamics of interleukin 1beta ( IL 1beta ) , tumor necrosis factor alpha ( TNF alpha ) , monocyte chemotactic protein 1 ( MCP 1 ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 2 , GRO / cytokine induced neutrophil chemoattractant 2alpha ( CINC 2alpha ) , intercellular adhesion molecule 1 ( ICAM 1 ) , leukocyte function associated antigen 1 ( LFA 1 ; CD11a / CD18 ) , and Mac 1 ( CD11b / CD18 ) in rat chronic reflux esophagitis . ^^^ Localization of adhesion molecules and cytokines was investigated by immunohistochemical staining , and numbers of LFA 1 or Mac 1 positive cells were quantified . ^^^ Numbers of LFA 1 and Mac 1 positive cells were significantly increased in rat chronic esophagitis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
ICAM 1 on endothelial cells mediates leukocyte adhesion by binding to leukocyte function associated antigen 1 ( LFA 1 ) and macrophage antigen 1 ( Mac 1 ) . ^^^ Recombinant mouse sICAM 1 induces the production of macrophage inflammatory protein 2 ( MIP 2 ) in mouse astrocytes by a novel LFA 1 and Mac 1 independent mechanism . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Loss of LFA 1 , but not Mac 1 , protects MRL / MpJ Fas ( lpr ) mice from autoimmune disease . ^^^ Mice deficient in LFA 1 , but not Mac 1 , showed significantly increased survival , decreased anti DNA autoantibody formation , and reduced glomerulonephritis . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Coincubation of eosinophils with integrin blocking monoclonal antibodies in adhesion assays showed that an association of the VLA 4 , LFA 1 , and Mac 1 integrins mediate the adhesion of SCA eosinophils to FN . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Contributions of LFA 1 and Mac 1 to brain injury and microvascular dysfunction induced by transient middle cerebral artery occlusion . ^^^ The objective of this study was to determine whether and how genetic deficiency of either lymphocyte function associated antigen 1 ( LFA 1 ) or macrophage 1 ( Mac 1 ) alters the blood cell endothelial cell interactions , tissue injury , and organ dysfunction in the mouse brain exposed to focal I / R . ^^^ Middle cerebral artery occlusion was induced for 1 h ( followed by either 4 or 24 h of reperfusion ) in wild type mice and in mice with null mutations for either LFA 1 or Mac 1 . ^^^ Mice with null mutations for LFA 1 or Mac 1 exhibited significant reductions in infarct volume . ^^^ However , after 24 h of reperfusion , leukocyte adhesion was reduced in both LFA 1 and Mac 1 deficient mice compared with their wild type counterparts . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The increase in costimulatory ( CD 80 and CD 86 ) and adhesion ( ICAM 1 , PGP 1 , LFA 1 , and Mac 1 ) in peripheral blood mononuclear cells was also attenuated by food restriction and to a lesser extent by fish oil alone . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
In particular , a specific interaction between kringle 4 and alphaMbeta 2 integrin ( Mac 1 ) but not leukocyte function antigen 1 ( LFA 1 ) was identified . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We examined the role of LFA 1 in CD 4 ( + ) T cell activation in vivo by using a system that allows for segregation of the migration and activation defects through the adoptive transfer of LFA 1 deficient ( CD 18 ( / ) ) CD 4 ( + ) T cells from DO11 . 10 Ag specific TCR transgenic mice into wild type BALB / c mice . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A number of receptor / ligand pairs have been shown to mediate costimulation , including CD28 / B7 molecules ( CD 80 and CD 86 ) , CD40 / CD40 ligand ( CD40L , CD 154 ) , and LFA 1 ( CD 18 ) / ICAM 1 ( CD 54 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Our purpose in this study was to examine the levels of soluble intracellular adhesion molecule 1 ( sICAM 1 ) and Mac 1 ( CD11b / CD18 ) , lymphocyte function associated antigen 1 ( LFA 1 ) in both neutrophils and lymphocytes in stable patients with COPD and in the healthy control groups consisting of non smokers , and in smokers without COPD and also to evaluate the relationship between the parameters related to the severity of the disease . ^^^ Flow cytometry was used for Mac 1 and LFA 1 levels . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To investigate mechanisms that may underlie the non progression that occurs in immunodeficiency virus infected chimpanzees , we amplified the protein coding regions of multiple non human primate ICAMs 1 5 and two ICAM ligands , leukocyte function associated antigen 1 ( LFA 1 ) and macrophage antigen 1 ( Mac 1 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Pneumococci also were used to challenge factor D deficient ( FD ( / ) ) , LFA 1 deficient ( LFA 1 ( / ) ) , and CD 18 deficient ( CD 18 ( / ) ) mice . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Lymphocyte function associated molecule 1 ( LFA 1 ; CD11a / CD18 ) influenced the capture phase of PMN binding to both melanoma cells and the endothelium , whereas Mac 1 ( CD11b / CD18 ) affected prolonged PMN melanoma aggregation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Reduction in the number of neutrophils was observed when antibodies against L selectin , CD 18 or LFA 1 were used , suggesting the involvement of these adhesion molecules in the effects of both PLA2s . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
We evaluated the inflammatory response and the expression of cellular adhesion molecules ( ICAM 1 , VCAM 1 , CD 18 , LFA 1 and Mac 1 ) in lungs of BALB / c mice infected with Paracoccidioides brasiliensis conidia . ^^^ CD 18 and Mac 1 but not LFA 1 were expressed with a high intensity on neutrophils and macrophages present in the inflammatory infiltrate . ^^^ CD 18 and Mac 1 but not LFA 1 were expressed with a high intensity on neutrophils and macrophages present in the inflammatory infiltrate . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Leukocyte cell adhesion molecules ( LFA 1 , Mac 1 and VLA 4 ) mobilization in circulating granulocytes were analysed by flow cytometry and endothelial cell adhesion molecules ( ICAM 1 and VCAM 1 ) were detected by immunohistochemistry on lung sections . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Beta 2 integrins / ICAM 1 adhesion mechanisms were examined and the results indicate LFA 1 and Mac 1 cooperate to mediate the PMN EC melanoma interactions under shear conditions . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The expression of the following cell adhesion molecules and their beta 1 and beta 2 integrin ligands was investigated in the liver tissue from 3 patients with non bacillar peliosis using light and electron microscope immunohistochemistry : intercellular adhesion molecule 1 ( ICAM 1 ) , vascular cell adhesion molecule 1 ( VCAM 1 ) , E selectin , platelet endothelial cell adhesion molecule 1 ( PECAM 1 ) , leukocyte function associated antigen 1 ( LFA 1 ) , macrophage antigen 1 ( Mac 1 ) , and very late antigen 4 ( VLA 4 ) . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Differential activation of LFA 1 and Mac 1 ligand binding domains . ^^^ Mutation of an invariant isoleucine residue in the 1 domains of alphaL and alphaM has previously been reported to activate LFA 1 and Mac 1 , respectively . ^^^ We find that mutation of the isoleucine residue in the proposed `` socket for isoleucine ' ' in full length alphaL does not lead to an active LFA 1 , although mutation of the equivalent residue in alphaM does convey constitutive activity to Mac 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Fundamentally different roles for LFA 1 , Mac 1 and alpha 4 integrin in neutrophil chemotaxis . ^^^ Although the LFA 1 , Mac 1 and alpha ( 4 ) integrins are required for chemotaxis , it is unknown how they are regulated or what specific role they play . ^^^ Here we show that these chemoattractants also activate and use Mac 1 and LFA 1 in a differential manner during chemotaxis . ^^^ Using integrin specific substrata , we demonstrate that cell movement in response to IL 8 is mediated by Mac 1 , whereas LFA 1 is required for directional migration . ^^^ By contrast , chemotaxis to fMLP requires Mac 1 for cell movement , whereas LFA 1 and alpha ( 4 ) integrin are required for directional migration . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
To evaluate this , we analyzed LFA 1 deficient ( CD 18 / ) CD4+CD25+ T cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Treating mice with antibodies to the beta 2 integrins LFA 1 and Mac 1 showed that LFA 1 was primarily responsible for mediating rolling on ICAM 1 in this model . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
CD 18 , the common beta subunit of beta 2 integrins , associates with four distinct alpha chains to give rise to four different beta 2 integrins : CD11a / CD18 ( LFA 1 ) , CD11b / CD18 ( Mac 1 ) , CD11c / CD18 ( CR 4 ) , and CD11d / CD18 . ^^^ Previously , we and others showed that CD 18 of LFA 1 serves as a receptor for Mannheimia haemolytica leukotoxin ( Lkt ) . ^^^ CD 18 , the common beta subunit of beta 2 integrins , associates with four distinct alpha chains to give rise to four different beta 2 integrins : CD11a / CD18 ( LFA 1 ) , CD11b / CD18 ( Mac 1 ) , CD11c / CD18 ( CR 4 ) , and CD11d / CD18 . ^^^ Level of expression of Mac 1 is higher than that of LFA 1 and other beta 2 integrins on polymorphonuclear leukocytes ( PMNs ) , which constitute the leukocyte subset most susceptible to Lkt . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
A reduction in the number of neutrophils was observed in the exudate when antibodies against LECAM 1 , CD 18 and LFA 1 were used , suggesting the involvement of these adhesion molecules in the effects of BaP 1 . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
LFA 1 ( CD11a / CD18 integrin ) influenced the capture phase of PMN binding to both melanoma cells and the endothelium , while Mac 1 ( CD11b / CD18 integrin ) affected prolonged PMN melanoma aggregation . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
BACKGROUND : Bone marrow macrophage surface expression of CD 18 ( MAC 1 , LFA 1 ) is involved in cellular binding to 5 CAM 1 and 5 CAM 2 adhesion molecules expressed on endothelial cells . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
Antibodies to HK receptors on leukocytes including Mac 1 , LFA 1 , uPAR , and C1qR inhibited IL 1beta secretion induced by tKa 98 % , 89 % , 85 % , and 62 % , respectively . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
The dissociation rates were calculated under low force conditions for ICAM 1 interactions with both beta 2 integrins , LFA 1 ( CD11a / CD18 ) and Mac 1 ( CD11b / CD18 ) , together and separately by using functional blocking antibodies on PMNs . ^^^
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20701 and P05107	Pubmed	SVM Score :0.0
NA