Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Presently , two cellular ligands for LFA 1 have been identified , termed ICAM 1 and ICAM 2 . ^^^ These studies provide evidence that ICAM 1 and ICAM 2 are not important target cell ligands for NK effector cell LFA 1 and that other target cell ICAM may exist . . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
This supports recent evidence for the existence of an additional ligand for LFA 1 , other than ICAM 1 and ICAM 2 . . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Thus , targeting LFA 1 alpha with mAb results in homotypic aggregation of T cell lines which is independent of ICAM 1 / LFA 1 interactions , but may involve other LFA 1 ligands such as ICAM 2 or ICAM 3 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Pop . 3 cells also express high levels of LFA 1 , ICAM 1 , and ICAM 2 , and a subset of them are VLA 4 alpha positive . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Blocking LFA 1 , LFA 3 , and ICAM 1 with monoclonal antibodies inhibited the adherence of T cells to thyroid follicular cells in assays of cell clustering ; antibodies against ICAM 2 had no effect . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Priming of CD4+ T cells with ICAM 1 induced higher expression of both CD 18 and CD 28 than that with either B 7 or ICAM 2 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
These new data showing that ICAM 1 , ICAM 2 and LFA 3 are , like LFA 1 , expressed on HC emphasize the ability of HC to act as APC . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
The addition of mAb directed at the CD11a or CD 18 molecules almost completely inhibited the responses to ICAM 2 Rg . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule 2 ( ICAM 2 ) , a cell surface glycoprotein , is a second counter receptor for lymphocyte function associated Ag 1 ( LFA 1 ) . ^^^ Furthermore , COS cells transfected with mouse ICAM 2 complementary and genomic DNA bind to purified human LFA 1 , demonstrating the conservation of the function of ICAM 2 as a ligand for LFA 1 and conservation across species of sequences that are critical for binding to human LFA 1 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
In common with ICAM 1 and ICAM 2 , ICAM R is a ligand for the beta 2 integrin CD11a / LFA 1 ( CD 18 ) . . ^^^ It has been found that cell cell adhesion which is dependent on expression of the leukocyte function associated antigen LFA 1 is not always blocked completely by antibodies raised against ICAM 1 and ICAM 2 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
It seems likely that the additional ligand for LFA 1 , ICAM 2 , is expressed on DC and contributes significantly to DC T cell adherence and T cell activation . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Characterization of ICAM 2 and evidence for a third counter receptor for LFA 1 . ^^^ Using this mAb , LFA 1 dependent binding to both stimulated and unstimulated endothelium was found to be totally accounted for by ICAM 1 and ICAM 2 . ^^^ Homotypic aggregation of an Epstein Barr virus transformed B cell line , JY , was found to be solely ICAM 1 and ICAM 2 dependent , while in the case of the T cell lymphoma cell line , SKW 3 , anti ICAM 2 mAb in conjunction with anti ICAM 1 mAb could not inhibit the LFA 1 dependent aggregation . ^^^ Using a cell binding assay to purified LFA 1 in conjunction with anti ICAM 1 and anti ICAM 2 mAb , we have demonstrated that this putative third ligand for LFA 1 exists on SKW 3 and other cell lines . . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
We have examined the expression and function of the cell adhesion molecules LFA 1 ( CD11a / CD18 ) , ICAM 1 ( CD 54 ) , and ICAM 2 in murine fetal thymic ontogeny and in the adult thymus . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
A monoclonal antibody ( mAb ) was raised that , in combination with blocking mAb to ICAM 1 and ICAM 2 , can completely inhibit binding of these cell lines to purified LFA 1 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
The intercellular adhesion molecules ICAM 1 and ICAM 2 are the cell surface ligands for the lymphocyte function associated antigen LFA 1 ( CD11a / CD18 ) and are thought to mediate cell cell adhesion interactions required by the immune system . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
The lymphocyte function associated molecule 1 ( LFA 1 , CD11a / CD18 ) is an integrin that mediates adhesion of immune cells by interaction with two members of the Ig superfamily , ICAM 1 and ICAM 2 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Two main molecular adhesion pathways have been characterized involving the CD 2 molecule binding the LFA 3 molecule and the LFA 1 molecule binding the ICAM 1 or ICAM 2 molecule . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Structure and regulation of the leukocyte adhesion receptor LFA 1 and its counterreceptors , ICAM 1 and ICAM 2 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Freshly isolated LC did not display ICAM 1 ( CD 54 ) , ICAM 2 , LFA 1 ( CD11a ) , and LFA 3 ( CD 58 ) , as detected by double color FACS analysis , using HLA DR expression for LC identification . ^^^ ICAM 2 and LFA 1 were undetectable on cultured LC and attempts to induce this expression by different culture conditions remained unsuccessful . mAb against ICAM 1 , LFA 1 , LFA 3 , and CD 2 , continuously present during culture , inhibited the T cell proliferative response to Candida albicans presented by cultured LC . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
To study the distribution of intercellular adhesion molecule receptor ( ICAM R , or ICAM 3 ) , a novel ligand for the leukointegrin lymphocyte function associated antigen 1 ( LFA 1 ) , in normal and rheumatoid synovial membranes and to compare this with the distribution of ICAM 1 , ICAM 2 , vascular cell adhesion molecule 1 ( VCAM 1 ) , and endothelial leukocyte adhesion molecule 1 ( ELAM 1 ) . ^^^ Although ICAM R is a ligand for LFA 1 and shares considerable sequence homology with ICAM 1 and ICAM 2 , it does not appear to be expressed by the endothelium of normal or inflamed synovial vessels . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Other ICAM 3 residues critical to adhesive interactions , such as Q 75 , conserved in ICAM 1 and ICAM 2 , but not VCAM 1 , may confer specificity to LFA 1 binding . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Furthermore , the aggregation induced by rapamycin was blocked by antibodies to the alpha ( CD11a ) or beta ( CD 18 ) subunits of the integrin , LFA 1 , or to its ligands , ICAM 1 and ICAM 2 , and did not occur in LFA 1 deficient YAC mutants . ^^^ However , the surface expression of LFA 1 , ICAM 1 , or ICAM 2 was not augmented in cells aggregated by rapamycin . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
We therefore examined the expression of the more recently identified LFA 1 ligand , ICAM 3 ( CD 50 ) , in comparison to ICAM 1 and ICAM 2 on blood DC and sought a functional role for ICAM 3 in DC mediated T lymphocyte responses . ^^^ However , the anti ICAM 3 mAb CAL 3 . 10 inhibited a DC stimulated MLR to a greater extent than anti ICAM 1 or anti ICAM 2 reagents and appeared to act by blocking the DC ICAM 3 T lymphocyte LFA 1 interaction . ^^^ As ICAM 3 is the predominant LFA 1 ligand on resting blood DC , we postulate that DC may utilize ICAM 3 for initial DC T lymphocyte interactions , and that ICAM 1 , which is up regulated upon DC activation , and / or ICAM 2 , may contribute to DC migration or later phases of the T lymphocyte activation process . . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
The beta 2 integrin consists of lymphocyte function antigen 1 ( LFA 1 , CD11a / CD18 ) which binds to the major ligand intracellular adhesion molecules 1 and 2 ( ICAM 1 and ICAM 2 ) , Mac 1 ( CD11b / CD18 , ligand iC3b ) and p 150 , 95 ( CD11c / CD18 , ligand iC3b ) . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
The present study examined the presence on human LC of the LFA 1 ligands ICAM 2 ( CD 102 ) and ICAM 3 ( CD 50 ) and their functional role in the activation of allogeneic T cells . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
The consistently high expression of ICAM 2 on all BL cell lines suggests that the accessory function in CTL recognition of these cells is mediated by the LFA 1 / ICAM 2 pathway . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Proliferation is also inhibited by mAbs to T cell CD 2 and LFA 1 beta chain ( CD 18 ) and by mAbs to LFA 3 ( CD 58 ) and CD 44 , which are expressed by T cells and EC . mAb to ICAM 1 ( CD 54 , a ligand for LFA 1 ) provides inconsistent inhibition , and mAb to ICAM 2 , used with or without anti ICAM 1 , is not inhibitory . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Intracellular adhesion molecule 2 ( ICAM 2 ) , one of the ligands of CD11a / CD18 ( LFA 1 ) , is mainly expressed on endothelial and hematopoietic cells . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Natural killer ( NK ) cells and CD8+ cytotoxic T lymphocytes ( CTL ) were shown to lyse C 1498 in vitro through the binding of leukocyte function antigen 1 ( LFA 1 ) on effectors and intercellular adhesion molecule 1 ( ICAM 1 ) and ICAM 2 on C 1498 target cells . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule ( ICAM ) 1 , ICAM 2 , and ICAM 3 have been identified as counter receptors for the leukocyte integrin lymphocyte function associated antigen 1 ( LFA 1 ) . ^^^ Similarly , purified Mac 1 does not support adhesion of ICAM 2 or ICAM 3 expressing L cell transfectants . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Three counter receptors for LFA 1 of the immunoglobulin family have been discovered : ICAM 1 , ICAM 2 , and ICAM 3 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Adhesion was also unaffected by antibodies to LFA 1 , ICAM 1 , ICAM 2 , LFA 2 , or LFA 3 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
The intercellular adhesion molecule 3 ( ICAM 3 ) has been identified as the third LFA 1 ligand in addition to ICAM 1 and ICAM 2 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Two ICAM 3 mAbs , CBR IC3 / 1 and CBR IC3 / 2 , were required to block LFA 1 dependent adhesion to purified ICAM 3 or LFA 1 dependent , ICAM 1 , ICAM 2 independent homotypic adhesion of lymphoid cell lines . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
ICAM 2 accounted for the majority of the LFA 1 dependent killing in the ICAM 1 negative target , neuro 2a / LN , while ICAM 1 played a primary role in the cytolysis of the ICAM 1+ transfectant . ^^^ Inhibition of lysis in the presence of anti ICAM 1 and ICAM 2 mAbs was comparable to that seen with the addition of anti LFA 1 mAb , indicating that other LFA 1 ligands were not involved in this system . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
LFA 1 ( CD11a / CD18 ) mediates leukocyte adhesion by binding to one of its ligands : ICAM 1 , ICAM 2 or ICAM 3 . ^^^ Here , we investigated whether stimuli known to induce adhesion to ICAM 1 were also capable of inducing LFA 1 mediated adhesion of T lymphocytes to ICAM 2 and 3 transfectants . ^^^ We observed that phorbol 12 myristate 13 acetate , Mn2+ , cross linking of CD 3 or activating antibodies against LFA 1 enhanced LFA 1 mediated T cell adhesion to ICAM 2 and 3 , although to a lesser extent than to ICAM 1 . ^^^ These results indicate that , similar to what has been reported for adhesion to ICAM 1 , activation of LFA 1 is also required for adhesion to ICAM 2 and 3 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
These results indicate that the interaction between LFA 1 and ICAM is a critical step in HIV mediated syncytia formation , and that ICAM 1 , ICAM 2 and ICAM 3 are the receptor molecules for the LFA 1 dependent syncytia formation . . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
U 266 and IM 9 myeloma cell lines express mainly CD 29 , CD49d , VLA 1 , CD 18 , CD 54 , ICAM 2 and ICAM 3 . ^^^ The combination of these MoAbs ( anti CD 29 , CD 18 , CD11a , CD49d , VLA 5 , CD 44 , CD 54 , ICAM 2 , ICAM 3 MoAbs ) decreased but did not completely abrogate binding of IM 9 to BMSCs . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
The three families of adhesion molecules that participate in this vital processes are the selectins , namely L selectin , E selectin and P selectin , the integrins : LFA 1 , CR 3 , p 150 . 95 and very late antigen 4 , and the immunoglobulin ( Ig ) superfamily which includes intercellular adhesion molecule 1 ( ICAM 1 ) , ICAM 2 and vascular cell adhesion molecule 1 ( VCAM 1 ) . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
This study details the expression of ICAM 1 and ICAM 2 , a ligand for LFA 1 , on cells of the DC lineage and examines their contribution to the DC stimulated MLR response . ^^^ Functional studies with CBR IC2 / 2 , an antibody known to block ICAM 2 binding to LFA 1 , did not have a significant inhibitory effect on the DC stimulated allogeneic MLR . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
The extracellular domain of LW consists , like that of ICAM 2 , of two immunoglobulin like domains , and the critical residues involved in the binding of LFA 1 to ICAMs were partially conserved in LW . . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
In fact , a receptor ligand interaction occurs between CD11a / CD18 ( LFA 1 ) and CD 2 molecules , expressed on the effector cells , and the respective counterparts on target cells , i . e . , ICAM 1 , ICAM 2 , or LFA 3 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
The leukocyte specific integrins CD11a / CD18 ( lymphocyte function associated antigen 1 ( LFA 1 ) ) and CD11b / CD18 ( complement type 3 receptor ( Mac 1 ) ) , which bind to the intercellular adhesion molecules ICAM 1 and ICAM 2 , play a key role in adhesion . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
One of the mAb to ICAM 2 partially or completely inhibits binding of cells expressing LFA 1 to purified ICAM 2 , and binding of cells expressing ICAM 2 to purified LFA 1 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Furthermore , the adhesion strengthening interaction observed for healthy neutrophils could be specifically inhibited by monoclonal antibodies ( mAbs ) to Mac 1 , but not to lymphocyte function associated antigen 1 ( LFA 1 ; CD11a / CD18 ) or intercellular adhesion molecule 2 ( ICAM 2 ; CD 102 ) . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Three ligands have been described for the leucocyte integrin LFA 1 , namely intercellular adhesion molecule ( ICAM ) 1 , ICAM 2 , and ICAM 3 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
In contrast , CD 18 ( beta 2 integrin ) , CD 61 ( beta 3 integrin ) , ICAM 2 , CD11a , CD11b and CD11c were all absent from these cells . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
These experiments were carried out in the presence of neutralising antibodies to CD 18 , CD11b , LFA 1 , E selectin , P selectin , intracellular adhesion molecule 1 ( ICAM 1 ) , and ICAM 2 ; a novel CD11b / CD18 antagonist , neutrophil inhibitory factor ( rNIF ) ; adenosine receptor agonists ( 5 ' N ethycarboxamido adenosine / N6 cylopentyladenosine ( NECA / CPA ) ) and a platelet activating factor ( PAF ) receptor antagonist lexipafant . ^^^ Adhesion of stimulated neutrophils to resting monolayers was Mac 1 , CD 18 dependent and ICAM 1 , ICAM 2 , E selectin , P selectin , PAF independent . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Intercellular adhesion molecule 2 ( ICAM 2 ) functions as a ligand for lymphocyte function associated antigen 1 ( LFA 1 ) and is involved in leukocyte adhesion . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Receptors of adhesion molecules ( ICAM 2 , ELAM 1 , LFA 1 ) were strongly expressed , mainly at the microvascular level in both unaffected and affected skin in the progressive phase , but were only weakly or not at all expressed in the stabilized phase , again in unaffected and affected skin . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
To identify potential molecular substrates for leukocyte trafficking and activation in multiple sclerosis ( MS ) brain , we determined the immunocytochemical distribution of the beta , integrin lymphocyte function associated antigen 1 ( LFA 1 ) and its major ligands , intercellular adhesion molecule ( ICAM ) 1 , ICAM 2 , and ICAM 3 in MS tissue . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Immunohistochemistry was performed for CD 18 , CD11a , CD11b , CD11c , alpha d , ICAM 1 , ICAM 2 , and ICAM 3 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Thy 1 induced HTA can not be blocked with MAb targeting intercellular adhesion molecule 1 and 2 ( ICAM 1 , ICAM 2 ) or LFA 1 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
As previously described , mouse LFA 1 does not bind to human ICAM 1 but we show here that mouse LFA 1 does bind to human ICAM 2 and 3 . ^^^ These results indicate that the LFA 1 binding sites for ICAM 1 and ICAM 2 and 3 , although in close vicinity , are distinct . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
The expression of ICAM 1 or ICAM 2 on RT10 . 3 cells significantly increased the stimulation of T cells in an LFA 1 ( CD11a / CD18 ) dependent manner as determined by thymidine incorporation . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
A bend between domains 1 and 2 of ICAM 2 and a tripod like arrangement of N linked glycans in the membrane proximal region of domain 2 may be important for presenting the recognition surface to LFA 1 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
T cell responses to TEC presented Sags were dependent on the presence of the adhesion molecules ICAM 1 , ICAM 2 , LFA 1 , and LFA 3 , but not on CD 4 and CD 8 molecules . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Retinoic acid induces aggregation of the acute promyelocytic leukemia cell line NB 4 by utilization of LFA 1 and ICAM 2 . ^^^ Aggregation was inhibited by neutralizing antibodies against LFA 1 and ICAM 2 . ^^^ Thus , tRA alters the adhesive properties of APL cells by inducing the expression of high avidity beta 2 integrins , aggregation is inhibited by LFA 1 and ICAM 2 MoAb , and tRA effects are rapidly reversible by MPSS . ^^^ Taken together , our findings provide a clinically relevant system for study of LFA 1 / ICAM 2 interaction and suggest a mechanism in part for retinoic acid syndrome and the effectiveness of MPSS in ameliorating retinoic acid syndrome . . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Tethering of PMN on platelet ICAM 2 via LFA 1 ( alphaLbeta 2 ) was observed , which may facilitate the transition between rolling on selectins and Mac 1 dependent arrest . ^^^ Mac 1 also bound to other unidentified ligands on platelets , which were not intracellular adhesion molecule 2 ( ICAM 2 ) , heparin , or heparan sulfate proteoglycans . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
No expression of intercellular adhesion molecule 2 ( ICAM 2 ) , E selectin ELAM 1 or lymphocyte function associated antigen 1 ( LFA 1 ) was observed on RPEC before or after virus infection . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Immunohistochemistry was performed for CD 18 , CD11a , CD11b , CD11c , alphad , ICAM 1 , ICAM 2 , and ICAM 3 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Adhesion molecules identified were intercellular adhesion molecule 1 ( ICAM 1 ) , ICAM 2 , ICAM 3 , vascular cell adhesion molecule 1 ( VCAM 1 ) , platelet endothelial cell adhesion molecule 1 ( PECAM 1 ) , E selectin , P selectin , L selectin , lymphocyte function associated antigen 1 ( LFA 1 ) , and very late activation antigen 4 ( VLA 4 ) . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Here we investigated in parallel the role of beta 2 integrin family members , LFA 1 ( CD11a / CD18 ) and Mac 1 ( CD11b / CD18 ) on monocytes , and the immunoglobulin supergene family members , ICAM 1 and ICAM 2 on HSF and on human umbilical vein endothelial cells ( HUVEC ) , in monocyte migration through HSF and HUVEC monolayers . ^^^ In contrast , both ICAM 1 and ICAM 2 mediated LFA 1 dependent monocyte migration through HUVEC . ^^^ However , neither ICAM 1 nor ICAM 2 was required for Mac 1 dependent monocyte migration through either cell barrier , indicating that Mac 1 can utilize ligands distinct from ICAM 1 and ICAM 2 on HSF and on HUVEC during monocyte transmigration . . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
For ICAM 1 and ICAM 2 , this glutamic acid residue is located on a flat surface , complementary to the flat surface of the 1 domain of the integrin to which they bind , lymphocyte function associated antigen 1 ( LFA 1 ) . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Surface bound platelets express ICAM 2 and GPIIbIIIa bound fibrinogen , which are ligands for LFA 1 and MAC 1 . ^^^ In addition , MAC 1 and LFA on PMN and ICAM 2 on platelets played a role in firm adhesion ; the effect of blocking antibodies was most evident at high shear . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
The increased binding induced by both cytokines and the TNF alpha induced sensitivity of SR 91 cells to NK 92 cell killing were abrogated by anti LFA 1 mAb as well as by a combination of antibodies against the three ligands of LFA 1 ( CD11a / CD18 ) , ICAM 1 ( CD 54 ) , ICAM 2 ( CD 102 ) and ICAM 3 ( CD 50 ) . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Mutating Thr 243 to alanine also had a profound effect on LFA 1 binding to ICAM 1 and 2 , as seen by complete loss of binding to ICAM 1 and a significant reduction ( 70 % decrease ) in binding to ICAM 2 . ^^^ Interestingly , mutating Lys 263 to alanine preferentially abolished LFA 1 binding to ICAM 2 . ^^^ In addition , this model , together with the ICAM 2 crystal structure , has been used to map residues that are likely to mediate LFA 1 1 domain binding to ICAM 2 . . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
LFA 1 interaction with ICAM 1 and ICAM 2 regulates Th 2 cytokine production . ^^^ By comparison , blocking CD28 / B7 costimulation inhibited IL 4 and IL 5 ( Th 2 cytokine ) production , whereas blocking LFA 1 / ICAM 1 or LFA 1 / ICAM 2 led to a significant increase ( 15 to 40 fold ) of Th 2 cytokines . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
We evaluated the relative contribution of ICAM 1 and ICAM 2 , known ligands on endothelium for LFA 1 and Mac 1 , in spontaneous neutrophil ( PMN ) transendothelial migration ( TEM ) across IL 1 activated HUVEC monolayers or TEM induced by C5a or IL 8 across unstimulated HUVEC grown on polycarbonate filters . ^^^ Adhesion blocking mAb to ICAM 1 [ R6 . 5 F ( ab ) 2 ] or ICAM 2 [ CBR IC2 / 2 F ( ab ) 2 ] tended to inhibit TEM under each condition but , in general , inhibition was significant only with both ICAM 1 and ICAM 2 blockade . mAb to LFA 1 partially inhibited migration to C5a or IL 8 across unstimulated HUVEC and inhibition was not altered by additional treatment of HUVEC with mAbs to ICAM 1 and 2 . ^^^ The results indicate that : ( 1 ) LFA 1 mediates PMN TEM primarily by interaction with ICAM 1 and ICAM 2 ; ( 2 ) ICAM 2 may function in concert with ICAM 1 in this role , especially on unstimulated endothelium , and ( 3 ) Mac 1 on PMN also plays a major role in TEM and can utilize yet to be identified ligands distinct from ICAM 1 or 2 , especially on unstimulated endothelium . . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Based on this crystal structure , we mutagenized ICAM 2 to localize the binding site for the integrin lymphocyte function associated antigen 1 ( LFA 1 ) . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
ICAM 2 , a constitutively expressed endothelial ligand for beta 2 integrins LFA 1 and Mac 1 , is involved in leukocyte adhesion to resting endothelium and in transmigration in vitro , however its role in inflammation is unclear . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Previous findings have shown that a peptide derived from the first Ig domain of ICAM 2 ( P 1 ) binds to LFA 1 ( CD11a / CD18 ) and Mac 1 ( CD11b / CD18 ) and activates leukocyte aggregation . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
The LFA 1 adhesion molecule is involved in cell adhesion events of leukocytes through binding to ICAM 1 , ICAM 2 and ICAM 3 . ^^^ Interestingly , we observed that LFA 1 / ICAM 1 co stimulation of T cells resulted in high production of the Th 2 cytokine IL 10 compared to ICAM 2 or ICAM 3 co stimulation . ^^^ In contrast , ICAM 2 and ICAM 3 induced a much stronger secretion of the Th 1 cytokine TNF alpha compared to LFA 1 / ICAM 1 induced co stimulation , despite the lower proliferation rate . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Here we show that cross linking of part of the LFA 1 molecules with Abs causes activation of free LFA 1 molecules ( not occupied by the Ab ) on the same cell , which then bind to ICAM 2 on other cells . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Adhesion molecules identified were intercellular adhesion molecule 1 ( ICAM 1 ) , ICAM 2 , ICAM 3 , vascular cell adhesion molecule 1 ( VCAM 1 ) , platelet endothelial cell adhesion molecule 1 ( PECAM 1 ) , E selectin , P selectin , L selectin , lymphocyte function associated antigen 1 ( LFA 1 ) , very late activation antigen 4 ( VLA 4 ) , Mac 1 ( CD18 / CD11b ) , and gp 150 , 95 ( CD18 / CD11c ) . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
RESULTS : Peripheral blood eosinophils constitutively expressed low levels of ICAM 1 and ICAM 2 ( < 10 FMI ) , moderate levels ( 10 50 FMI ) of CD 29 and L selectin , and high levels ( > 50 FMI ) of ICAM 3 , LFA 1 , and Mac 1 . ^^^ L selectin expression decreased at 6 and 24 h , but ICAM 2 , ICAM 3 , LFA 1 , and CD 29 expression did not show any significant change after calcium ionophore stimulation . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Serial colonic sections ( 10 UC , 10 CD , and 10 controls ) were stained immunohistochemically for ICAM 1 , ICAM 2 , ICAM 3 , CD11a , CD11b , CD 18 , and PECAM 1 . ^^^ In conclusion , CD11b , CD 18 , and ICAM 2 seem to be important for PMN transepithelial migration in UC , whereas CD11a , CD11c , ICAM 1 , and ICAM 3 seem central in leukocyte locomotion and aggregation in CD . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Consistent with this observation , immobilized , purified ICAM 2 , a specific counter receptor for LFA 1 , did not support the adhesion dependent phase of superoxide production . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
LFA 1 and its ligands , ICAM 1 , ICAM 2 , and ICAM 3 , can be expressed on the cells infected by HIV , as well as on the HIV virions themselves . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Agglutination induced by A 80 was inhibited by stromal cell derived factor 1 , T 22 , and phorbol 12 myristate 13 acetate but was not significantly altered by pretreatment of cells with pertussis toxin , wortmannin , or MAbs to LFA 1 , ICAM 1 , ICAM 2 , and ICAM 3 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Binding of LFA 1 ( CD11a ) to intercellular adhesion molecule 3 ( ICAM 3 ; CD 50 ) and ICAM 2 ( CD 102 ) triggers transmigration of human immunodeficiency virus type 1 infected monocytes through mucosal epithelial cells . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
ICAM 2 engagement by CD19+ cells of its natural receptor , LFA 1 , on CD4+ naive cells specifically induced AKT activity in the absence of an MHC peptide interaction . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Linear and cyclic peptides derived from the sequences of LFA 1 , ICAM 1 , ICAM 2 , VCAM 1 , and FN C 1 have been shown to have inhibitory effects in vitro and in vivo . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Blocking monoclonal antibodies were used against the platelet and neutrophil surface receptors glycoprotein complex IIb / IIla , P selectin , ICAM 2 , CD11a , CD11b , and CD 18 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
All the cytokines tested ( interleukin 1beta ( IL 1beta ) , IL 2 , IL 4 , IL 7 , IL 10 , interferon gamma ( IFN gamma ) ) as well as CAMs ( ICAM 1 , ICAM 2 , VCAM 1 , LFA 1 and CD 44 ) were expressed at substantial levels in both spleen and LNs . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Fluorescence activated cell sorting analyses showed that neither tumors nor ascitic cells grown in SCID mice expressed leukocyte function associated antigen ( LFA ) 1alpha ( CD11a ) , LFA 1lbeta ( CD 18 ) , LFA 2 ( CD 2 ) , LFA 3 ( CD 58 ) , intercellular adhesion molecule ( ICAM ) 1 ( CD 54 ) , ICAM 2 ( CD 102 ) , ICAM 3 ( CD 50 ) , or leukocyte endothelial adhesion molecule ( LECAM ) 1 ( CD62L ) , suggesting that these cytoadhesion molecules are not involved in tumor formation of RM P 1 cells in vivo . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Although the integrin LFA 1 is a counter receptor for both ICAM 2 and ICAM 3 , on DC , DC SIGN is the high affinity adhesion receptor for ICAM 2 / 3 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
IL 1beta is a co stimulator in activating Th cells , which manifests its activity together with LFA 1 , ICAM 1 and ICAM 2 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
RESULTS : Specific cation dependent binding of lymphocytes to bronchial endothelium was observed which was significantly inhibited by antibodies against P selectin , PSGL 1 , L selectin , LFA 1 , ICAM 1 and ICAM 2 but not E selectin , VLA 4 , VCAM 1 or Mac 1 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
The beta ( 2 ) integrin LFA 1 ( CD11a / CD18 ) is a leukocyte specific adhesion molecule that mediates leukocyte extravasation , antigen presentation , and T cell mediated cytolysis through its interaction with its counter receptors , ICAM 1 , ICAM 2 , and ICAM 3 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
In a comparison of LFA 1 ligands , intercellular adhesion molecule 2 ( ICAM 2 ) and ICAM 3 promoted LFA 1 directed perforin release , whereas ICAM 1 had little effect . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
Sialylation of ICAM 2 on platelets impairs adhesion of leukocytes via LFA 1 and DC SIGN . ^^^ Purified , immobilized platelet ICAM 2 supported 50 % less adhesion of LFA 1 bearing T cells than did purified HUVEC ICAM 2 and no adhesion was observed of monocyte derived immature dendritic cells via DC SIGN to platelet ICAM 2 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
High structural similarity to Dl domains of ICAM 1 and ICAM 2 , and common features in amino acid sequence between X 4 and ICAM 1 , suggest X 4 to possess binding activity for the alpha ( L ) integrin 1 domain of LFA 1 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
When the reactivity of mNI 11 and mAbs binding human differentiation antigens such as CD11a , CD11b , CD11c , CD 14 , CD 16 , CD 18 , CD 23 , CD 28 , CD 29 , CD 31 , CD 43 , CD 44 , CD45RA , CD49d , CD 50 , CD 54 , CD 58 , CD 80 , CD 102 , CD 106 , HLA class 1 , or HLA class 2 antigen was compared , no mNI 11 reactivity resembling that of these mAbs was found . mNI 11 markedly induced homotypic cell aggregation of U 937 cells when they were stimulated with LPS . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
When the reactive patterns between mNI 58A and the mAbs to various human differentiation antigens ( CD11a , CD11b , CD11c , CD 14 , CD 16 , CD 18 , CD 23 , CD 28 , CD 29 , CD 31 , CD 43 , CD 44 , CD45RA , CD 50 , CD 54 , CD 58 , CD 80 , CD 102 , CD 106 , HLA class 1 and class 2 antigen ) were compared , that of mNI 58A was found to be similar to those of the leukocyte function associated antigen 1 ( LFA 1 ) mAbs . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
DLGL are CD56bright and express the CD 2 , CD11a , CD 18 , CD 38 and CD 50 molecules , dimly the CD 54 molecule , and poorly the CD 102 and CD 69 molecules . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
When the reactivity of mNKES and mouse mAbs recognizing the human adhesion associated antigen ( CD 10 , CD11a , CD11b , CD11c , CD 14 , CD 16 , CD 18 , CD 23 , CD 28 , CD 29 , CD 31 , CD 43 , CD 44 , CD45RA , CD 50 , CD 54 , CD 58 , CD 80 , CD 102 , CD 106 , and HLA class 1 , and HLA class 2 antigen ) with various cell lines was compared , mNKES reactivity was found to be unique , not resembling that of any of these mouse mAbs . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
CBDC expressed the CD 4 , CD11a , CD 18 , CD45RA , CD 50 and CD 54 antigens but revealed no expression of the CD1a , CD11c , CD 40 , CD45R0 , CD 58 , CD 83 , CD 86 and CD 102 antigens . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
CBDC expressed CD 4 , CD11a , CD 18 , CD45RA , CD 50 , CD 54 , and CD 123 , but showed no expression of CD1a , CD11c , CD 33 , CD 40 , CD45R0 , CD 80 , CD 83 , and CD 86 and only limited expression of CD 58 , CD 102 , and CD 116 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
We analyzed the phenotype of CB monocytes in the presence or absence of an inflammatory signal ( rIFN gamma ) and compared them to adult blood ( AB ) ; the expression of HLA DR and 17 different markers ( CD11a , CD11b , CD11c , CD 18 , CD 29 , CD 40 , CD 44 , CD49a , CD49d , CD49e , CD49f , CD 54 , CD 58 , CD62L , CD 80 , CD 86 and CD 102 ) was measured by flow cytometry . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
They expressed CD 4 , CD11a , CD11b , CD11c , CD 18 , CD 32 , CD 33 , CD45R0 , CD 48 , CD 50 , CD 54 , CD 58 , CD 64 , CD 86 , CD 102 , CD 116 , CD 123 , and HLA DR ; showed no expression of CD1a and CD 83 ; and weak expression of CD 16 , CD45RA , and CD 80 . ^^^
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13598 and P05107	Pubmed	SVM Score :0.0
NA