| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| Basement membrane proteins , laminin , and collagen type 4 , as well as vitronectin and fibronectin , were identified in the intima and there was corresponding expression of integrin and non integrin receptors ( e . g . , CD 29 , CD49b , CD49d , CD49e , CD49f , CD 51 , CD 61 , CD 44 ) for these matrix proteins . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| Primary mast cells were found to react with mAbs directed against the common beta chain of beta 1 integrins ( CD 29 ) , the alpha chain of VLA 4 ( CD 49 d ) and VLA 5 ( CD 49 e ) , the beta chain of beta 3 integrins ( CD 61 ) , and the alpha chain of the vitronectin receptor ( VNR ) ( CD 51 ) . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| The second integrin shares the same beta subunit ( beta 3 or GPIIIa ) , but has a distinct alpha subunit that comigrates with the alpha subunit ( alpha 5 ) of the vitronectin receptor ( VnR ) on endothelial cells and reacts with a monoclonal antibody , LM 142 , which was raised against an integrin from M 21 melanoma cells . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| Polyclonal antibodies ( pab ) directed against human platelet GPIIb / IIIa and the vitronectin receptor ( VnR ) , and mouse monoclonal antibodies ( mab ) against human GPIIb , GPIIIa or the GPIIb / IIIa complex were used . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor alpha and interferon gamma modulate the expression of the vitronectin receptor ( integrin beta 3 ) in human endothelial cells . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| Both OCs and FBGCs expressed the alpha chains of the vitronectin receptor ( CD 51 ) and of the VLA 2 ( CDw49b ) and VLA 4 ( CDw49d ) molecules as well as their respective beta chains , gpIIIa ( CD 61 ) and CD 29 . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| The heterodimeric vitronectin receptor ( VNR ) and platelet glycoprotein IIb / IIIa ( GPIIb / IIIa ) are two members of the integrin family of cell adhesion receptors that share the same beta subunit ( GPIIIa ) . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| Glycoprotein IIIa ( GPIIIa or beta 3 subunit ) is the common beta subunit of the beta 3 subfamily of integrins , which , when associated with glycoprotein IIb ( GPIIb ) , constitutes the receptor for fibrinogen and other adhesive proteins at the platelet surface ( the GPIIb IIIa complex ) and , when associated with the alpha 5 subunit , constitutes the vitronectin receptor present in several cell types . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| We have been studying two populations having an unusually high frequency of Glanzmann disease , Iraqi Jews and Arabs living in Israel , and were able to distinguish the populations on the basis of immunodetectable GPIIIa and platelet surface vitronectin receptor ( alpha 5 beta 3 ) expression . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| We found that polyclonal antibodies to the platelet GPIIb IIIa complex , GPIIIa , and the human vitronectin receptor inhibited TSP mediated cell adhesion by 63 68 % . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| A cDNA encoding a new form of the shared beta subunit ( beta 3 ) of the platelet integrin gpIIb / IIIa and the vitronectin receptor was isolated from a placental cDNA library by screening with a beta 3 ( gpIIIa ) DNA probe . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| The proband ' s platelets bound more antibodies against the vitronectin receptor alpha 5 beta 3 than normal platelets , suggesting a normal GPIIIa ( beta 3 ) gene and a defect in the GPIIb gene . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| Transfection of CS 1 melanoma cells with a cDNA encoding the wild type integrin beta 3 subunit , results in de novo alpha 5 beta 3 expression and cell attachment , spreading , and migration on vitronectin . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| Almost all of the vitronectin adherent cells expressed CD 51 , CD 61 , kit , and tryptase , and exhibited metachromasia with toluidine blue . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| Further , while GPIIIa is expressed in other tissues as part of the vitronectin receptor , GPIIb is only expressed on maturing megakaryocytes and the platelets derived from them . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| As judged by monoclonal antibody binding studies , surface glycoprotein ( GP ) IIb / IIIa ( alpha IIb beta 3 ) expression was less than 15 % of normal and alpha 5 beta 3 vitronectin receptor expression was 15 % to 19 % of normal , suggesting that the defect was in GPIIIa ( beta 3 ) . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| Receptor expression was measured by flow cytometry with monoclonal murine anti human antibodies CD 9 ( p 24 ) , CD42B ( Ib ) , CD41b ( IIb ) , CD 61 ( IIIa ) , CD41a ( IIb / IIIa ) , CD49b ( VLA 2 ) , CD62p ( P selectin ) , CD 31 ( PECAM 1 ) , and CD51 / CD61 ( vitronectin ) . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| Receptor expression was measured by flow cytometry with monoclonal antibodies to p 24 ( CD 9 ) , Ib ( CD42b ) , IIb ( CD41b ) , IIIa ( CD 61 ) , IIb / IIIa ( CD41b / CD61 ) , very late antigen 2 ( CD49b ) , P selectin ( CD62p ) , platelet / endothelial cell adhesion molecule 1 ( CD 31 ) ; and vitronectin ( CD51 / CD61 ) . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| In contrast , changing Gln 344 , the homologue to Arg 327 in the alpha subunit of the vitronectin receptor , to His did not prevent the surface expression of alphav GPIIIa complexes . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| Low ETS 1 expression cells could not spread on a vitronectin substratum , and the phosphorylation of focal adhesion kinase was markedly impaired because of the reduced expression of integrin beta 3 . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| Cell colony density was evaluated basally ( endothelial plus colon tumor cells ) and following the addition of : purified vWF , vWF plus vWF blocking antibodies , antibodies against various integrins and adhesion molecules ( alpha 2 b integrin , beta 1 integrin , beta 3 integrin , intercellular adhesion molecule 1 , intercellular adhesion molecule 2 , vitronectin receptor CD 61 CD51 , laminin alpha6 / beta4 receptor ) , and various drugs inhibiting the hemostatic system ( ticlopidine , heparin , acetyl salicylic acid [ ASA ] , defibrotide , indobuphen , dipyridamole , sulfinpyrazone ) . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| The GPIIIa ( beta 3 integrin ) is an integral part of two glycoprotein receptors the GP ( IIb / IIIa ) fibrinogen receptors in platelets and the GP ( V / IIIa ) vitronectin receptors in endothelium and vascular smooth muscle cells ( vSMC ) . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| Megakaryocytic cells isolated from these cultures ( 1 ) express several markers characteristic of this lineage ( CD 41 , CD 61 , CD 62 P , CXCR 4 , PAR 1 , etc . ) , ( 2 ) respond by calcium flux and phosphorylation of various intracellular proteins to stimulation by thrombin and ( 3 ) adhere to fibrinogen and vitronectin . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| CD 61 or beta 3 integrin also associates with alpha 5 ( CD 51 ) to form the vitronectin receptor , which is expressed in many tissues . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| The present studies were undertaken ( 1 ) . to confirm whether the disulfide rich repeat region of GPIIIa contains target epitopes for antiplatelet antibodies in patients with ITP ; ( 2 ) . to determine whether these antigens were defined by peptide sequences in the absence of post translational modification ; and ( 3 ) . to correlate observed immunologic reactivity with the recently solved 10 ray crystallographic structure of an analogous integrin complex , the vitronectin receptor , alpha ( 5 ) beta ( 3 ) . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| Quantitative flowcytometric analysis showed an elevated number of vitronectin receptors , a component of which is GPIIIa , on the patient ' s platelets . ^^^ |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04004 and P05106 |
Pubmed |
SVM Score :0.0 |
| NA |
|