| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Liver type arginase ( arginase 1 ) is expressed almost exclusively in the liver and catalyzes the last step of urea synthesis , whereas the nonhepatic type ( arginase 2 ) is expressed in extrahepatic tissues . ^^^ Liver type arginase ( arginase 1 ) is expressed almost exclusively in the liver and catalyzes the last step of urea synthesis , whereas the nonhepatic type ( arginase 2 ) is expressed in extrahepatic tissues . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation experiments revealed the constitutive presence of arginase 1 in both unactivated and LPS activated cells and arginase 2 induction by LPS . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analysis showed that iNOS and arginase 1 proteins were also induced . mRNA for arginase 2 , an arginase isozyme , was not detected in the LPS activated peritoneal cells . mRNA for CCAAT / enhancer binding protein beta ( C / EBPbeta ) , a transactivator of the arginase 1 gene , was also induced , and the induction was more rapid than that of arginase 1 mRNA . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Liver type arginase ( arginase 1 ) is expressed almost exclusively in the liver and catalyzes the last step of urea synthesis , whereas the nonhepatic type ( arginase 2 ) is expressed in extrahepatic tissues and is probably involved in down regulation of nitric oxide synthesis . ^^^ Liver type arginase ( arginase 1 ) is expressed almost exclusively in the liver and catalyzes the last step of urea synthesis , whereas the nonhepatic type ( arginase 2 ) is expressed in extrahepatic tissues and is probably involved in down regulation of nitric oxide synthesis . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| It was 59 % identical with arginase 1 . mRNA for human arginase 2 was present in the kidney and other tissues but was not detected in the liver . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| The murine arginase 2 gene contains eight exons like the arginase 1 gene . ^^^ The six internal exons have intron / exon boundaries that are identical to the arginase 1 gene ; however , exon three of the arginase 2 gene has obtained a three base pair insertion . ^^^ The promoter region of the arginase 2 gene , which bears no resemblance to that of the arginase 1 genes , contains numerous potential binding sites for enhancer and promoter elements but does not contain a TATA box . . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| In contrast to our knowledge regarding macrophage iNOS expression , the stimuli and mechanisms that regulate expression of the cytosolic type 1 ( arginase 1 ) or mitochondrial type 2 ( arginase 2 ) isoforms of arginase in macrophages are poorly defined . ^^^ Dexamethasone , which did not induce either arginase or iNOS , almost completely abolished induction of arginase 1 mRNA by 8 bromo cAMP but enhanced induction of arginase 2 mRNA . ^^^ Lipopolysaccharide ( LPS ) induced arginase 2 mRNA , but 8 bromo cAMP plus LPS resulted in synergistic induction of both arginase 1 and 2 mRNAs . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| It is synthesized from ornithine by argininosuccinate synthetase and argininosuccinate lyase and is degraded by arginase , which consists of a liver type ( arginase 1 ) and a non hepatic type ( arginase 2 ) . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Arginase , which catalyzes the conversion of arginine to urea and ornithine , and consists of a liver type ( arginase 1 ) and a non hepatic type ( arginase 2 ) . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Arginase exists in two isoforms , the hepatic ( arginase 1 ) and extrahepatic types ( arginase 2 ) . ^^^ In contrast , both arginase 1 and arginase 2 are induced in LPS activated mouse peritoneal macrophages . ^^^ Early induction of iNOS , arginase 2 , AS , ODC , and cationic amino acid transporter 2 and late induction of arginase 1 were observed in LPS activated peritoneal macrophages . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Two isoforms of mammalian arginases exist , hepatic arginase 1 and extrahepatic arginase 2 . ^^^ Similar to murine BMMPhi , murine bone marrow derived dendritic cells , as well as a dendritic cell line , up regulated arginase 1 expression and arginase activity upon Th 2 stimulation , whereas arginase 2 was never detected . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| RESULTS : In RT PCR analysis , arginase 2 ( nonhepatic type ) mRNA was detected in retina and weakly in cornea , whereas arginase 1 ( hepatic type ) mRNA was not detected in any area . mRNAs for argininosuccinate synthetase , argininosuccinate lyase , ornithine aminotransferase and ornithine decarboxylase were present in all areas . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| The results show that RASMC contain basal arginase 1 ( AI ) activity , which is significantly enhanced by stimulating the cells with either interleukin ( IL ) 4 or IL 13 , but arginase 2 ( AII ) expression was not detected under any condition studied here . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| To understand the roles of arginase isoforms in EC arginine metabolism , bovine coronary venular EC were stably transfected with the Escherichia coli lacZ gene ( lacZ EC , control ) , rat arginase 1 cDNA ( AI EC ) , or mouse arginase 2 cDNA ( AII EC ) . ^^^ Western blots and enzymatic assays confirmed high level expression of arginase 1 in the cytosol of AI EC and of arginase 2 in mitochondria of AII EC . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| As stromal keratitis progressed ( days 8 15 p . i . ) arginase 1 mRNA was induced tenfold , in contrast to a moderate decrease in arginase 2 and a loss of iNOS expression . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Polyamines are essential for cell proliferation ; therefore , we hypothesized that arginase 1 or arginase 2 activities , via production of ornithine for polyamine synthesis , may be limiting for proliferation of endothelial cells ( EC ) . ^^^ Bovine coronary venular EC stably transfected with a lacZ gene ( lacZ EC , control ) , rat arginase 1 cDNA ( AI EC ) , or mouse arginase 2 cDNA ( AII EC ) were utilized to test this hypothesis . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Arginase is encoded by two recently discovered genes ( Arginase 1 and Arginase 2 ) . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to compare the effect of other heavy metal ions on the rat liver isozyme ( arginase 1 ) and the rat kidney isozyme ( arginase 2 ) . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| In conclusion , arginase 2 was induced in BDL livers , while the expression of arginase 1 was down regulated . ^^^ Reduction of arginase 1 in BDL livers may be responsible for the lowering of arginine levels in the plasma , while induction of arginase 2 could be important in regulating NO synthesis as well as other important mechanisms involved in liver cirrhosis . . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| NF kappa B dependent induction of arginase 2 , but not arginase 1 , was observed in RAW 264 . 7 macrophages cocultured with H . pylori . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Using RT PCR , renal tissues were examined further for the expression of iNOS , CAT 1 , CAT 2 , arginase 1 and arginase 2 . ^^^ In addition , the expression of arginase 2 and arginase 1 mRNA was attenuated by 30 minutes and one hour of reperfusion , and returned to baseline values after 24 hours of reperfusion . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical analysis showed that arginase 1 is induced in macrophages , whereas arginase 2 is induced in various cell types , including macrophages and myofibroblasts , and roughly colocalizes with the collagen specific chaperone heat shock protein 47 . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| There was no regional variation in arginase 1 or arginase 2 protein expression across the sub regions of the hippocampus . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Genes related to metabolism of basic amino acids , specifically the cationic amino acid transporter 2 , arginase 1 , and arginase 2 , were particularly prominent among the asthma signature genes . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Microarray analysis of the expression profiles of lung tissue in two murine models of asthma revealed high levels of arginase 1 and arginase 2 activity , in association with IL 4 and IL 13 overexpression , suggesting that arginine pathways are critical in the pathogenesis of asthma . . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| It is metabolized in macrophages by inducible nitric oxide synthase to produce nitric oxide , important in the cytotoxic mechanisms , and by arginase 1 ( ASE 1 ) and arginase 2 ( ASE 2 ) to synthesize L ornithine and urea , the first being the precursor for the production of polyamines needed for cell proliferation . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Using RT PCR mRNA for arginase 1 was clearly detectable with 30 PCR cycles , whereas mRNA for arginase 2 was hardly detectable with 35 PCR cycles . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Experiments on the intracellular distribution and the effects of the arginase inhibitors ornithine and N ( omega ) hydroxy L arginine ( NOHA ) , suggested the presence of both arginase 1 and arginase 2 in rat submandibular gland . . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Transcripts of murine arginase 1 and hypoxanthine phosphoribosyl transferase ( HPRT ; housekeeping gene ) or murine arginase 2 analyte and porphobilinogen deaminase ( PBGD ; housekeeping gene ) were quantified in such duplex RT PCRs . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Arginase 1 and arginase 2 mRNA expression was higher in macrophages from infected BALB / c compared with those from C57BL / 6 mice , whereas iNOS mRNA was up regulated at the same level in both phenotypes . ^^^ Moreover , increase of arginase 1 and arginase 2 mRNA levels and of macrophage arginase activity was directly induced by trypanosomes , with a higher level in BALB / c compared with C57BL / 6 mice . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| We found that the cationic amino acid transporter ( CAT ) 2 , arginase 1 , and arginase 2 were particularly prominent among the allergen induced gene transcripts . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| We examined the effects of unilateral vestibular deafferentation ( UVD ) on the expression of four enzymes associated with neuronal plasticity , neuronal nitric oxide synthase ( nNOS ) , endothelial nitric oxide synthase ( eNOS ) , arginase 1 and arginase 2 ( AI and 2 ) , in the rat EC and PRC using Western blotting . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Aortic arginase 1 and arginase 2 expression as well as arginase activity were evaluated by western blotting and the spectrophotometric method , respectively . ^^^ Finally , as compared with WKY rats , SHR exhibited increased expression of vascular arginase 1 ( +72 % , P < 0 . 05 ) and arginase 2 ( +91 % , P < 0 . 05 ) as well as increased arginase activity ( +26 % , P < 0 . 05 ) . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| There were no age related changes in total arginase activity or arginase 1 and arginase 2 protein expression . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Levels of arginase 1 protein and arginase 2 mRNA were increased in response to L / T treatment , and genistein prevented the L / T induced elevations in both arginase 1 protein and arginase 2 mRNA levels . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| To examine the interaction of human arginase 2 ( EC 3 . 5 . 3 . 1 ) with substrate and manganese ions , the His120Asn , His145Asn and Asn149Asp mutations were introduced separately . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| At the gene level , arginase 2 gene expression was upregulated by cAMP stimulation , while arginase 1 gene expression was not influenced . ^^^ Thus , in contrast to mammals , fish arginase 2 and not arginase 1 is differentially regulated and likely involved in the alternative activation of fish macrophages . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Induction of arginase 2 mRNA was also enhanced by rolipram but to a much lesser extent than arginase 1 . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : A recent microarray study implicated arginase 1 ( ARG 1 ) and arginase 2 ( ARG 2 ) in mouse allergic asthma models and human asthma . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| We found that the cationic amino acid transporter ( CAT ) 2 , arginase 1 , and arginase 2 were particularly prominent among the allergen induced gene transcripts . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| The expression of arginase 2 , but not arginase 1 , isoform was detected in monocytes and dendritic cells . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Whereas , the enhanced overall arginase activity at term gestation seems to be because of the induced functional arginase 1 in concert with the attenuated arginase 2 expression . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Reduced synthesis of nitric oxide ( NO ) contributes to the endothelial dysfunction and may be related to limited availability of L arginine , the common substrate of constitutive nitric oxide synthase ( NOS ) and cytosolic arginase 1 and mitochondrial arginase 2 . ^^^ Interestingly , the mitochondrial arginase 2 was constitutively expressed , whereas the cytosolic arginase 1 was barely detectable in HUVECs . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Liver type arginase ( EC 3 . 5 . 3 . 1 ) catalyzes the last step of urea synthesis and is expressed specifically in the liver of ureotelic animals . ^^^ |
|
| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| The gene for human liver type arginase ( EC 3 . 5 . 3 . 1 ) , a urea cycle enzyme , was cloned and the structure was determined . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| These spots were identified as arginase 1 ( liver type arginase ; EC 3 . 5 . 3 . 1 ) and mitochondrial enoyl CoA hydratase 1 ( EC 4 . 2 . 1 . 17 ) . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Except for a few differences , the structure of tRNA Arg 2 is very similar to the structure of tRNA Arg 1 reported by Murao et al . 3 . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| There was little or no cleavage of proalbumin Lille ( Arg 2 His ) or Christchurch ( Arg 1 Gln ) , and there was negligible cleavage of proalbumin Blenheim ( Asp 1 Val ) , despite the fact that it retains the dibasic processing signal . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| The sequences of Saccharomyces cerevisiae mitochondrial tRNA Arg 1 , tRNA Arg 2 , tRNA Gly , tRNA Lys 2 , tRNA Leu amd tRNA Pro are reported . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Determination of the distribution and kinetics of induction of mRNAs transcribed from the five auxin regulated genes of mung bean , which include Aux22s and SAUR as well as ARG 1 and ARG 2 , shows that they are heterogeneous in their mode of gene expression . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Ni2+ binds to a site in the N terminal region of the protein which is partially blocked by the presence of a propeptide as in proalbumin ( proAlb ) Varese ( Arg 2 > His ) , proAlb Christchurch ( Arg 1 > Gln ) and proAlb Blenheim ( Asp 1 > Val ) and by the presence of only an extra Arg residue ( Arg 1 ) as in Arg Alb and albumin ( Alb ) Redhill . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| The type strain of H . argentinensis is strain arg 1 ( = JCM 9737 ) , and the type strain of H . mukohataei is strain arg 2 ( = JCM 9738 ) . . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Type 2 arginase ( Arg 2 ) mRNA was detected in normal glomeruli ; nephritic glomeruli expressed both Arg 1 and Arg 2 mRNAs . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| METHODS : Four albumin preparations , modified chemically at lysine or arginine residues , respectively , to contain N epsilon carboxymethyllysine ( CML albumin ) , N epsilon carboxyethyllysine ( CEL albumin ) , glyoxal induced imidazolinones ( Arg 1 albumin ) or methylglyoxal induced imidazolinones ( Arg 2 albumin ) were applied . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Cloning and disruption of the Pichia pastoris ARG 1 , ARG 2 , ARG 3 , HIS 1 , HIS 2 , HIS 5 , HIS 6 genes and their use as auxotrophic markers . ^^^ Screening of a partial genomic database of Pichia pastoris allowed us to identify the ARG 1 , ARG 2 , ARG 3 , HIS 1 , HIS 2 , HIS 5 and HIS 6 genes , based on homology to their Saccharomyces cerevisiae counterparts . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Two arginases Arg 1 and Arg 2 were separated by DEAE Sepharose column . ^^^ |
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| Interacting proteins: P78540 and P05089 |
Pubmed |
SVM Score :0.0 |
| Although both Arg 1 and 2 mRNA and protein were present in whole heart , Arg 2 alone was found in isolated myocytes . ^^^ |
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