| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| Peripheral blood lymphocytes derived from tuberous sclerosis ( TS ) patients showed unusually high levels of plasminogen activator ( PA ) activity after treatment with N methyl N ' nitro N nitrosoguanidine ( MNNG ) . ^^^ Serum obtained from peripheral blood of TS patients also enhanced the PA activity level when normal control lymphocytes were incubated with the serum prior to MNNG treatment . ^^^ Thus , it seems likely that serum from TS patients contains factors which are responsible for the unusual PA induction and which have a similar epitope to HuIFN beta . . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| The most affected segments were either vRNA 4 , vRNAs 4 and 7 , or vRNAs 4 , 6 , and 7 in cells infected , respectively , with ts mutants C 15 ( ts lesion in PB 1 gene ) , C 45 ( ts lesion in PA gene ) and CmN 3 ( ts lesion in NS gene ) . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| Also , the infusion of B cells taken from animals immunized with either MP or PA suppressed the antibody response of naive recipients to MP or PA , respectively , relative to controls , suggesting that Ts cells respond to determinants on immune B cells . ^^^ These studies suggest that Ta and Ts cells can modulate the antibody response to MP , SM , and PA in a positive and negative manner , respectively . . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| Furthermore , compared with a PA and TS reduces the occurrence of coordination problems and stop of inhalation when the aerosol is fired ; otherwise there seems to be little clinical difference between a PA and a TS . 5 . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| We found that the polymerase PA gene of the ca parent specifies the ca phenotype and that the PB 2 and PB 1 genes independently specify the ts phenotype . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| Reassortant SG3r was non ts and virulent , indicating that mutation of the PA gene was sufficient for the reversion of the ts and attenuation phenotypes expressed by SG3rFL . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| For the PA group , the components of MET metabolism were as follows : S , 20 + / 0 . 5 ; B , 24 + / 0 . 5 ; TM , 5 . 8 + / 0 . 6 ; RM , 1 . 8 + / 0 . 4 ; and TS , 4 . 0 + / 0 . 4 ( + / SE ) mumol . kg 1 . h 1 . ^^^ The increase in HCY recycling , relative to TS ( these two pathways of HCY disposal constitute the `` HCY locus ' ' ) , in the fed state did not reach statistical significance when compared with the PA state . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| Only reassortants which inherited the PA gene from ca B / AA / 1 / 66 expressed the ts phenotype in MDCK cells at 39 degrees C . ^^^ Isolation of a virulent , non ts revertant virus inheriting only the PA gene from ca B / AA / 1 / 66 established a direct relationship between expression of the ts phenotype and attenuated virulence . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| The kinase activity of the transforming protein pp60src in lysates of PA 17 infected cells cultured at permissive or restrictive temperatures was labile in RIPA buffer , as in the case of some previously examined ts T mutants . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| In cells infected with the ts 166 mutant having a ts mutation in gene 3 , coding for the PA polypeptide , a drastic reduction was observed in poly ( A+ ) cRNA synthesis under non permissive conditions . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| For this purpose , we measured PMV on the basis of tg , ts , 5 , tun , Pa and Clo in 15 working areas . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| The ts mutation in ts 451 could be extragenically suppressed by replacement of the PB 1 and / or PA protein genes of the mutant by the allelic genes of PR 8 . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| Mating the ts+ revertants with wild type virus yielded ts progeny in high frequency , indicating that the loss of ts phenotype was due to a suppressor mutation which was mapped to the PA gene in each of the four independently derived ts phenotypic revertants . ^^^ These studies suggest that single amino acid changes at aa 245 ( Glu Lys ) or 347 ( Asp Asn ) of the PA protein can completely suppress the ts and attenuation phenotypes specified by the Asp Ser mutation at aa 265 of the PB 2 protein of the A / Ann Arbor / 6 / 60 cold adapted virus . . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| Using the recombination analysis in chick embryo fibroblasts ( CEF ) we determined that influenza A / HK / 17 ir ca virus carries ts mutations in three `` internal ' ' genes , i . e . , PB 1 , NP and M , and influenza A / Vic / 30 ir ca virus carries ones in four genes , i . e . , PA , NP , M and NS . ^^^ Thereafter our data result in conclusion that ts mutations in the PA gene must lead to some insignificant contribution for the expression of general ts phenotype among the ca strains as far as this sign is clearly displayed by both viruses , although only one of them , i . e . , A / HK / 17 ir carries ts mutation in the HA gene . . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| The temperature sensitive defect of mutant ts 263 of fowl plague virus ( FPV ) is located in the acidic polymerase ( PA ) gene and is due to a single base substitution ( C2036T ) , which leads to an amino acid replacement ( Ala 671 to Val ) in a highly conserved region of the protein . ^^^ During passage at 33 degrees C ts 263 stably carries over a ninth RNA segment , which consists of a truncated PA gene . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| Ninety children , aged 1 3 years , undergoing day case adenoidectomy were randomly allocated to three groups : group TS received thiopentone 5 mg kg 1 and suxamethonium 1 . 5 mg kg 1 , group H 5 Vol . % halothane and group PA alfentanil 10 micrograms kg 1 and propofol 3 mg kg 1 for induction of anaesthesia . ^^^ Tracheal intubation was successful at the first attempt in all children in groups TS and H and but only in 80 % in group PA ( P = 0 . 001 ) . ^^^ Intubating conditions were excellent in 22 ( 73 % ) , 22 ( 73 % ) and one ( 3 % ) of the patients in groups TS , H and PA , respectively ( P = 0 . 001 ) . ^^^ Bradycardia occurred in 0 ( 0 % ) , four ( 14 % ) and six ( 21 % ) children in groups TS , H and PA , respectively ( P = 0 . 007 PA vs . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| When continuous controlled mechanical ventilation ( CMV ) was applied with ventilator frequency increased as little as 1 cycle / min > eupnea and Pa ( CO ( 2 ) ) and VT maintained at near eupneic control levels , EMG ( di ) was silenced and triangularis sterni EMG ( EMG ( ts ) ) became tonic within 2 to 5 ventilator cycles . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| Comparison of kj data for corresponding Ts located between +1 and 10 regions of Pa promoter in dsDNA and in ssDNA form in the open transcription complex , reported elsewhere , demonstrates that reactivity of pyrimidines in dsDNA is by 2 3 orders of magnitude smaller . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| Sequencing of the gene encoding ts 53 PA and recombinant virus rescue experiments revealed that an amino acid change from Leu to Pro at amino acid position 226 is causative of temperature sensitivity . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| Bulk samples ( n = 107 ) collected from farms across CT , MD , NY , PA , and VA were highly variable in total solids ( TS ) concentration , ranging from 11 to 213gL ( 1 ) , in suspensions ' pH ( 6 . 3 9 . 2 ) , and EC ( 6 . 2 53 . 3 dS m ( 1 ) ) . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| Result : The contractile responsiveness of PA and TA to KCl and PE decreased significantly or very significantly after TS 7 d and TSI 4 d . ^^^ The dilatory reactivity of PA and TA to ACh after TS 7 d had a significant or very significant increase , but reactivity of PA showed no change and TA showed only a tendency to increase after TS 14 d . ^^^ After preconditioning with 10 ( 5 ) moles / L L NAME , responsiveness of PA to PE after TS 7 d and TS 14 d had no difference among the three groups , but responsiveness of TA to PE after TS 7 d and TS 14 d had a significant decrease . ^^^ The dilatory reactivity of PA after TS 7 d decreased significantly or very significantly , and the remains showed no significant change . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| DESIGN , SETTING , AND PATIENTS : TS women ( n = 93 ) were compared with normal controls ( n = 25 ) and women with 46 , 20 primary amenorrhea ( PA ) ( n = 11 ) with a similar history of estrogen deficiency . ^^^ Similarly , increased IMT in TS and 46 , 20 PA women suggests that estrogen deficiency contributes to intimal thickening . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| A detailed mutational analysis revealed that a combination of two sites in NP ( A 114 and H 410 ) and one in PA ( M 431 ) controlled expression of ts , whereas these same changes plus two additional residues in M 1 ( Q 159 and V 183 ) controlled the att phenotype . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| Ions monitored were m / z 297 . 0 > 251 . 0 for CTS , m / z 295 . 0 > 249 . 0 for TS 2 A , and m / z 361 . 1 > 233 . 0 for FOFB with argon at a pressure of 0 . 2 Pa and collision energy of 25 eV for collision induced dissociation ( CID ) . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| MATERIAL AND METHODS : A total of 1408 human 2PN embryos were cryopreserved using a Planer Kryo 10 Series 3 freezing unit ( TS Scientific , Perkasie , Pa ) after dehydration / equilibration through Propanediol ( Sigma Chemical , St . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| The total surface area ( TS ) of the disc section was divided into an anterior surface area ( AS ) and a posterior area ( PA ) , in accordance with a line joining the center of the condyle ( C ) to the center of the articular tubercle of the temporal bone ( T ) . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| Previously , it has been determined that the PA and NP segments of MDV B control the ts phenotype while the att phenotype requires the M segment in addition to PA and NP . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| We therefore investigated the effects of TMS , DMS , and SPN on ( a ) PA induced by ADP and thrombin ; ( b ) PA induced by melanoma cell line B16 / BL6 ; and ( c ) experimental lung colonization as well as spontaneous lung metastasis of BL 6 cells in syngeneic C57BL / 6 mice . ^^^ In experiments on agonist induced PA , TMS inhibited PA and ATP secretion 5 fold more strongly than DMS or SPN . ^^^ Tumor cell ( BL 6 melanoma ) induced PA and ATP secretion were also strongly inhibited by TMS , but not by DMS or SPN . ^^^ Since many previous studies suggested that the ability of tumor cells to induce PA is related to the degree of malignancy ( e . g . , metastatic potential ) of tumor cells , we studied the effect of TMS on lung metastatic potential . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| The upper limit of the partial pressure measurement by KEMS of approximately 10 Pa does not apply for TMS , which enables measurements up to pressures of approximately 0 . 1 MPa . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| Paired pulse TMS was applied with a circular coil oriented to produce antero posterior ( AP ) current flow in the right motor cortex ( to preferentially evoke I 3 waves in corticospinal neurons ) and with postero anterior ( PA ) currents ( to preferentially evoke I 1 waves ) . ^^^ Paired pulse TMS was less effective in suppressing the muscle evoked potential ( MEP ) when the muscle was targeted for selective activation , with both AP and PA stimulation . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| In both sets of experiments , 3 types of TMS pulse were used : monophasic posterior anterior ( PA ) induced current in the brain , monophasic anterior posterior induced current ( AP ) , and biphasic PA / AP stimulation . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| A conditioning TMS pulse ( CP ) applied to left M 1 or dPM with an intensity of 80 % and 60 % active motor threshold ( CP ( 80 % AMT ) and CP ( 60 % AMT ) , respectively ) was followed by a test pulse ( TP ) over right M 1 induced by anterior posterior or posterior anterior ( TP ( AP ) , TP ( PA ) ) directed currents in the brain at interstimulus intervals ( ISIs ) of 3 8 and 10 ms . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| TMS pulses over the hand area of motor cortex activate different subpopulations of synaptic connections if the direction of the induced current in the brain is reversed from posterior anterior ( PA ) direction to anterior posterior ( AP ) . ^^^ We propose that the increased effectiveness of AP Sub PAS over PA Sub PAS is due to the fact that AP TMS more readily activates I 3 inputs to corticospinal neurons and hence that these are an important component of associative plasticity in the human motor cortex . . ^^^ |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04818 and Q9UL45 |
Pubmed |
SVM Score :0.0 |
| NA |
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