| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.83102827 |
| We have previously shown that HSP 22 interacts with itself as well as with HSP 27 , MKBP , and cvHSP . 0.83102827^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| Coimmunoprecipitation experiments showed greater binding of both HSPB 8 mutants to the interacting partner HSPB 1 . ^^^ |
|
| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| A similar rapid induction was found for the small heat shock genes ( hsp 22 , hsp 23 , hsp 26 , and hsp 27 ) . ^^^ |
|
| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| Nine proteins have been assigned to date to the superfamily of mammalian small heat shock proteins ( sHsps ) : Hsp 27 ( HspB 1 , Hsp 25 ) , myotonic dystrophy protein kinase binding protein ( MKBP ) ( HspB 2 ) , HspB 3 , alphaA crystallin ( HspB 4 ) , alphaB crystallin ( HspB 5 ) , Hsp 20 ( p 20 , HspB 6 ) , cardiovascular heat shock protein ( cvHsp [ HspB 7 ] ) , Hsp 22 ( HspB 8 ) , and HspB 9 . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| Recently a new sHSP , HSP 22 ( HSPB 8 , H 11 ) , was identified in the human heart by its interaction with HSP 27 ( HSPB 1 ) . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| We studied expression of these proteins in porcine lens , brain , heart , liver , kidney , lung , skeletal muscle , stomach , and colon , and found a ubiquitous expression of Hsp 20 and HspB 8 as earlier reported for Hsp 27 and alphaB crystallin . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| Mutations in HSPB 1 and HSPB 8 , members of the small heat shock protein family , have recently been shown to cause some distal motor neuropathies . ^^^ |
|
| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| Hsp 27 , Hsp 20 and HspB 8 are both lysine and glutamine donors , alphaB crystallin only is a lysine donor , HspB 2 a glutamine donor , and HspB 3 no substrate at all . ^^^ |
|
| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| The relative levels of alphaB crystallin , HspB 8 , Hsp 20 , Hsp 27 , Hsp 60 , and Hsp 70 as well as nitric oxide synthases ( NOS ) ( endothelial NOS , inducible NOS , neuronal NOS ) were examined by Western blot analysis . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| Recently , mutations in HSPB 1 ( HSP 27 ) and HSPB 8 ( HSP 22 ) , two members of the small HSP superfamily , have been associated with inherited peripheral neuropathies . ^^^ In this review , we will summarize the current knowledge of small HSPs , in particular HSPB 1 and HSPB 8 , and discuss their role in health and disease . . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| In vitro , monocyte derived DCs were stimulated with recombinant alphaA crystallin , alphaB crystallin , HSP 20 , HSPB 8 , and HSP 27 . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| Genes for small heat shock proteins ( hsp 27 to hsp 22 ) are activated in late third instar larvae of Drosophila melanogaster in the absence of heat stress . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| The 67B locus contains a cluster of heat shock genes , four of which ( hsp 22 , hsp 23 , hsp 26 , hsp 28 ) are ecdysterone inducible . ^^^ Experiments on the transcription of these genes in salivary glands of pupating larvae showed that hsp 23 and hsp 28 mRNAs were most abundant in the larvae while hsp 26 and hsp 22 had intermediate or low level of accumulation , respectively . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| The inhibition was highly specific : expression of the closely related heat shock proteins hsp 22 , hsp 23 , and hsp 28 was unaffected . ^^^ |
|
| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| Perturbations were induced near hsp 27 and hsp 22 , coupled with an extensive domain of chromatin unfolding in the intergenic region between hsp 23 and the developmentally regulated gene 1 . ^^^ |
|
| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| Topoisomerase 1 was found to interact with the transcriptionally active genes hsp 22 , hsp 23 , hsp 26 , and hsp 28 after heat shock but not with the inactive genes before heat shock . ^^^ |
|
| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| Unique coding sequences for four heat shock proteins of Drosophila melanogaster , hsp 28 , hsp 26 , hsp 23 , and hsp 22 , are clustered in a 12 kilobase interval at chromosome subdivision 67B . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| By using a map of the unique region of DNA encoding the fur small heat shock proteins of Drosophila melanogaster ( hsp 22 , hsp 23 , hsp 26 , and hsp 28 ) , and a simple mapping technique , the positions of the DNase 1 hypersensitive sites of chromatin in the vicinity of these genes have now been determined . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| In addition to hsp 23 , the synthesis of the low molecular weight heat shock polypeptides hsp 22 , hsp 26 , and hsp 27 was also stimulated by ecdysterone , although to different extents . ^^^ |
|
| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| While hsp 23 and hsp 27 transcripts accumulate at relatively high levels , those of hsp 22 and hsp 26 are present at low and intermediate levels , respectively . ^^^ |
|
| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| During development , each of the four members of the small heat shock protein family ( Hsp 27 , Hsp 26 Hsp23 and Hsp 22 ) , which are coordinately induced in response to a heat stress , shows a specific pattern of expression in diverse tissues and cells . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| Genetic variation in total mRNA level of the six hsp genes ( hsp 22 , hsp 23 , hsp 26 , hsp 27 , hsp 70 and hsp 82 ) in the presence of heat shock was investigated by using seventy four second and seventy third chromosome lines of Drosophila melanogaster which have the same genetic background derived from a highly inbred stock . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| Drosophila melanogaster has four main small heat shock proteins ( Hsps ) , D . melanogaster Hsp 22 ( DmHsp 22 ) , Hsp 23 ( DmHsp 23 ) , Hsp 26 ( DmHsp 26 ) , and Hsp 27 ( DmHsp 27 ) . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| HSP 22 , a new member of the small heat shock protein superfamily , interacts with mimic of phosphorylated HSP 27 ( ( 3D ) HSP 27 ) . ^^^ According to the two hybrid data , HSP 22 interacts preferentially with the triple aspartate form of HSP 27 as compared with wild type HSP 27 . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| A newly identified 22 kDa protein that interacts with Hsp 27 ( heat shock protein 27 ) was shown to possess the characteristic alpha crystallin domain , hence named Hsp 22 , and categorized as a member of the sHsp ( small Hsp ) family . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| Thus , it has been demonstrated that mutation of either Hsp 27 or the related protein hsp 22 can be observed in specific families with hereditary motor neuropathy caused by premature axonal loss , possibly due to neuronal death and subsequent degeneration . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| Heat shock protein 22 ( HSP 22 ) is a molecular counterpart of HSP 27 , and its mutation is another cause of distal HMN . ^^^ We screened the mutation of HSP 27 and HSP 22 in 68 Japanese patients with axonal CMT or unclassified CMT and six Japanese patients with distal HMN . ^^^ We detected a heterozygous P182S mutation of HSP 27 in a patient with distal HMN , but we found no mutations in HSP 22 . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| The Drosophila melanogaster family of small heat shock proteins ( sHsps ) is composed of 4 main members ( Hsp 22 , Hsp 23 , Hsp 26 , and Hsp 27 ) that display distinct intracellular localization and specific developmental patterns of expression in the absence of stress . ^^^ Heat induced aggregation of citrate synthase was decreased from 100 to 17 arbitrary units in the presence of Hsp 22 and Hsp 27 at a 1 : 1 molar ratio of sHsp to citrate synthase . ^^^ In an in vitro refolding assay with reticulocyte lysate , more than 50 % of luciferase activity was recovered when heat denaturation was performed in the presence of Hsp 22 , 40 % with Hsp 27 , and 30 % with Hsp 23 or Hsp 26 . ^^^ |
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| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| Using the yeast two hybrid method , quantitative fluorescence resonance energy transfer in live cells , and cross linking , we found aberrantly increased interactions of mutant HSP 22 forms with themselves , with wild type HSP 22 , and with the other sHSPs , alphaB crystallin , and HSP 27 . ^^^ A mutation ( S135F ) in HSP 27 that is also associated with these disorders showed increased interaction with wild type HSP 22 also , suggesting linkage of these two etiologic factors , HSP 22 and HSP 27 , into one common pathway . ^^^ |
|
| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UJY1 and P04792 |
Pubmed |
SVM Score :0.0 |
| NA |
|