| Interacting proteins: P04792 and Q9UER7 |
Pubmed |
SVM Score :0.52597604 |
| However , we find no evidence that HSP 27 interacts with DAXX in DU 145 cells . 0.52597604^^^ |
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| Interacting proteins: P04792 and Q9UER7 |
Pubmed |
SVM Score :0.0 |
| Here we show that phosphorylated dimers of HSP 27 interact with Daxx , a mediator of Fas induced apoptosis , preventing the interaction of Daxx with both Ask 1 and Fas and blocking Daxx mediated apoptosis . ^^^ No such inhibition was observed with an HSP 27 phosphorylation mutant that is only expressed as oligomers or when apoptosis was induced by transfection of a Daxx mutant lacking its HSP 27 binding domain . ^^^ However , HSP 27 blocked Fas induced translocation of Daxx from the nucleus to the cytoplasm and Fas induced Daxx and Ask 1 dependent apoptosis . ^^^ |
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| Interacting proteins: P04792 and Q9UER7 |
Pubmed |
SVM Score :0.0 |
| Release of Daxx correlated with Hsp 25 suppression , suggesting that Daxx normally inhibits immediate Hsp 25 production . ^^^ |
|
| Interacting proteins: P04792 and Q9UER7 |
Pubmed |
SVM Score :0.0 |
| The interaction of HSP 27 with Daxx identifies a potential regulatory role of HSP 27 in Fas induced apoptosis . ^^^ We found that phosphorylated dimers of HSP 27 interact with Daxx , preventing its interaction with Ask 1 and Fas and blocking Daxx mediated apoptosis . ^^^ Expression of HSP 27 also prevents the translocation of Daxx from the nucleus to the cytoplasm which is induced upon expression of Ask 1 or stimulation of Fas . ^^^ Whereas the FADD axis can be modulated by expression of FLIP , a natural inhibitor of FADD , our results show that HSP 27 can accomplish a similar function for the Daxx axis . . ^^^ |
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| Interacting proteins: P04792 and Q9UER7 |
Pubmed |
SVM Score :0.0 |
| DAXX co immunoprecipitated with HSP 27 , suggesting an inhibitory role of HSP 27 in VP 16 mediated activation of the ASK1 / p38 / JNK pathway . ^^^ |
|
| Interacting proteins: P04792 and Q9UER7 |
Pubmed |
SVM Score :0.0 |
| While total RNA yield and abundance were not significantly altered , both iron and aluminum were found to induce HSP 27 , COX 2 , betaAPP and DAXX gene expression . ^^^ |
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| Interacting proteins: P04792 and Q9UER7 |
Pubmed |
SVM Score :0.0 |
| T cells and suppress expression of 17 genes including IL 6 , PlGF , Daxx , and HSP 27 . ^^^ |
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