| Interacting proteins: Q92529 and P04629 |
Pubmed |
SVM Score :0.0 |
| N Shc : a neural specific adapter molecule that mediates signaling from neurotrophin / Trk to Ras / MAPK pathway . ^^^ |
|
| Interacting proteins: Q92529 and P04629 |
Pubmed |
SVM Score :0.0 |
| Grit , a GTPase activating protein for the Rho family , regulates neurite extension through association with the TrkA receptor and N Shc and CrkL / Crk adapter molecules . ^^^ |
|
| Interacting proteins: Q92529 and P04629 |
Pubmed |
SVM Score :0.0 |
| The results indicate that these Shc family members possess both unique and overlapping functions in regulating neural development and suggest physiological roles for ShcB / ShcC in TrkA signaling . . ^^^ |
|
| Interacting proteins: Q92529 and P04629 |
Pubmed |
SVM Score :0.0 |
| ShcB and ShcC activation by the Trk family of receptor tyrosine kinases . ^^^ Although a previous study suggested that ShcB and ShcC do not strongly interact with the Trk receptors ( 1 ) , we find that ShcB and ShcC bind the Trk receptors in a phosphotyrosine dependent manner via their N terminal phosphotyrosine binding domain at Tyr ( 499 ) ( TrkA ) and Tyr ( 515 ) ( TrkB ) , they are tyrosine phosphorylated in response to neurotrophin stimulation , and they enhance the activation of mitogen activated protein kinase in Trk expressing cells . ^^^ Moreover , neurotrophin treatment of primary cortical neurons stimulates ShcB / ShcC Trk interaction and the tyrosine phosphorylation of ShcB / ShcC , indicating that they are bona fide targets of the Trk receptors in vivo . ^^^ Collectively , these results demonstrate that ShcB and ShcC , and their co immunoprecipitating proteins , are activated by the Trk receptors in primary neurons . . ^^^ |
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| Interacting proteins: Q92529 and P04629 |
Pubmed |
SVM Score :0.0 |
| Comparative expression profiles of Trk receptors and Shc related phosphotyrosine adapters during retinal development : potential roles of N Shc / ShcC in brain derived neurotrophic factor signal transduction and modulation . ^^^ |
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| Interacting proteins: Q92529 and P04629 |
Pubmed |
SVM Score :0.0 |
| Because the Shc family proteins ( ShcA , ShcB , and ShcC ) are adaptors for various receptors , including Trk receptors , and are regulators of neuronal cell development , we speculated that they may play a role in neuroblastoma . ^^^ |
|
| Interacting proteins: Q92529 and P04629 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92529 and P04629 |
Pubmed |
SVM Score :0.0 |
| NA |
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