Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins . ^^^
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
Importantly , we demonstrate that the phosphotyrosine binding domain of FRS 2 directly binds the Trk receptors at the same phosphotyrosine residue that binds the signaling adapter Shc , suggesting a model in which competitive binding between FRS 2 and Shc regulates differentiation versus proliferation . ^^^ The signaling adapter FRS 2 competes with Shc for binding to the nerve growth factor receptor TrkA . ^^^ Consistent with this model , FRS 2 binds Grb 2 , Crk , the SH 2 domain containing tyrosine phosphatase SH PTP 2 , the cyclin dependent kinase substrate p 13 ( suc 1 ) , and the Src homology 3 ( SH 3 ) domain of Src , providing a functional link between TrkA , cell cycle , and multiple NGF signaling effectors . ^^^ Importantly , overexpression of FRS 2 in cells expressing an NGF nonresponsive TrkA receptor mutant reconstitutes the ability of NGF to stop cell cycle progression and to stimulate neuronal differentiation . . ^^^
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
While FGFR 1 interacts with FRS 2 constitutively , independent of ligand stimulation and tyrosine phosphorylation , NGF receptor ( TrkA ) binding to FRS 2 is strongly dependent on receptor activation . ^^^
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
Herein , we demonstrate that acidic substitution of the activation loop tyrosines is sufficient to induce allosteric changes required for constitutive TrkA kinase activity as well as phosphorylation of TrkA signaling proteins such as Shc , PLCgamma 1 , FRS 2 and erk1 / 2 . ^^^
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
Grb 2 binding to TrkA is independent of Shc , FRS 2 , phospholipase Cgamma 1 , rAPS , and SH2B and is observed in in vitro binding assays , yeast two hybrid assays , and in co immunoprecipitation assays . ^^^
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
Thus , the activation of FRS 2 and Shc ( leading to MAPK activation ) is weaker in the DDR1 / TrkA chimeras than in TrkA alone , and the PLCgamma contribution becomes essential for full response . ^^^
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
Two fibroblast growth factor ( FGF ) receptor substrates ( FRS 2 and FRS 3 ) are involved in downstream signaling from activated FGF receptors and neurotrophin activated Trk receptors . ^^^
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
Overexpression of the signaling adapter FRS 2 reconstitutes the cell cycle deficit of a nerve growth factor non responsive TrkA receptor mutant . ^^^ Collectively , these data suggest a model in which NGF stimulated TrkA dependent activation of FRS 2 supports neurite outgrowth through a mechanism that likely involves the induction of p 21 ( Waf1 / Cip1 ) expression and the arrest of cells at G ( 1 ) / S . . ^^^
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
This interaction and phosphorylation of RasGrf 1 is dependent on the HIKE domain of TrkA ( a region shown to interact with pleckstrin homology domains ) but not on any of the phosphotyrosine residues that act as docking sites for intracellular signaling molecules such as Shc and FRS 2 . ^^^
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
Finally , in PC 12 cells , NGF stimulated tyrosine phosphorylation of SNT was dependent on the levels of Trk tyrosine kinase activity and was constitutively induced by expression of pp60v src . ^^^ However , Ras was not required for constitutive SNT tyrosine phosphorylation , suggesting that this protein functions distally to Trk and pp60v src but in a pathway parallel to that of Ras . ^^^
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
Trk also induces the tyrosine phosphorylation of SNT , a specific target of neurotrophic factor activity in neuronal cells . ^^^
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
In C 6 2B cells stably transfected with the rat trkA cDNA , NGF increased c fos mRNA , induced tyrosine phosphorylation of gp140trk , and SNT ( suc associated neurotrophic factor induced tyrosine phosphorylated target ) , and caused morphological changes within 72 h . ^^^
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
Both TrkC and TrkA mediate qualitatively similar increases in the tyrosine phosphorylation of phospholipase C ( PLC ) gamma 1 , Shc , SNT , and MAPK and the transcription of the c fos , c jun , NGFI A , and NGFI B immediate early genes . ^^^
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
This system utilizes a Trk receptor mutant ( Trk ( def ) ) lacking sequences Y 490 , Y 785 and KFG important for the activation of the major Trk targets ; SHC , PLC gammal , Ras , PI 3 kinase and SNT . ^^^
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q8WU20 and P04629	Pubmed	SVM Score :0.0
NA