| Interacting proteins: P62834 and P04629 |
Pubmed |
SVM Score :0.63575125 |
| Linking the complex to Rap 1 activation , we coprecipitated activated TrkA and activated MAPK with activated Rap 1 in NGF treated cells . 0.63575125^^^ |
|
| Interacting proteins: P62834 and P04629 |
Pubmed |
SVM Score :0.0 |
| We show that PI 3 K is required for TrkA internalization and participates in NGF signaling to ERKs via distinct actions on the small G proteins Ras and Rap 1 . ^^^ We show here that Rap 1 activation requires both TrkA internalization and PI 3 K , whereas Ras activation requires neither TrkA internalization nor PI 3 K . ^^^ The results of this study suggest that PI 3 K may be required for the signals initiated by TrkA internalization and demonstrate that specific endocytic events may distinguish ERK signaling via Rap 1 and Ras . . ^^^ |
|
| Interacting proteins: P62834 and P04629 |
Pubmed |
SVM Score :0.0 |
| As a result , Trk receptor signaling activates several small G proteins , including Ras , Rap 1 , and the Cdc 42 Rac Rho family , as well as pathways regulated by MAP kinase , PI 3 kinase and phospholipase C gamma ( PLC gamma ) . ^^^ |
|
| Interacting proteins: P62834 and P04629 |
Pubmed |
SVM Score :0.0 |
| Moreover , Ang 2 induced the phosphorylation of TrkA ( maximum at 5 min of incubation in the presence of serum or at 20 min in cells depleted in serum for 2 h ) and a rapid increase in Rap 1 activity , both effects abolished in cells preincubated with 10 microm AG 879 . ^^^ |
|
| Interacting proteins: P62834 and P04629 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P62834 and P04629 |
Pubmed |
SVM Score :0.0 |
| NA |
|