| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| Downstream from TrkA , a mitogen activated protein kinase cascade , which includes Erk 1 and Erk 2 , is operating . ^^^ |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| The enhanced responsiveness to NGF in E 2 cells is not due to receptor overexpression as judged by TrkA protein levels and tyrosine kinase activity , but may be associated with the increased and prolonged tyrosine phosphorylation of ERK 1 ( extracellular signal regulated kinase 1 ) and ERK 2 . ^^^ |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| This increase in trkA receptor phosphotyrosine is reflected in increased activation of both Erk 1 and Erk 2 and of the catalytic subunit of phosphatidylinositol 3 kinase . ^^^ |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| In the present study , we have addressed the existence of a differentiation specific mode of activation and subcellular distribution of the extracellular signal regulated kinases ERK 1 and ERK 2 in SH SY5Y / wt and SH SY5Y / TrkA . ^^^ |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| Consistent with the presence of trkB but not trkA , BDNF causes rapid phosphorylation of MAP kinases ERK 1 and ERK 2 , but NGF does not . ^^^ |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NGF treatment of PC12nnr5 cells expressing Trk with mutations in either substrate binding site resulted in normal neurite outgrowth and Erk 1 activity and tyrosine phosphorylation . ^^^ However , PC12nnr5 cells expressing Trk with mutations at both sites failed to stably extend neurites and efficiently induce Erk 1 activity and tyrosine phosphorylation in response to NGF . ^^^ We postulate that Trk receptors can activate Erk 1 by either SHC or PLC gamma 1 dependent signaling pathways . ^^^ |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| IL 6 and Trk / NGF synergized in enhancing tyrosine phosphorylation of the Erk 1 mitogen activated protein kinase and in activating expression of certain NGF target genes . ^^^ |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| Xaliproden does not activate the Trk receptor but causes a rapid increase in the activities of the ERK 1 and ERK 2 isoforms of MAP kinase , which then rapidly decrease to the basal level . ^^^ |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P27361 |
Pubmed |
SVM Score :0.0 |
| NA |
|