Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.54533293
NRAGE blocks the physical association of p75NTR with TrkA , and , conversely , TrkA overexpression eliminates NRAGE mediated NGF dependent death , indicating that interactions of NRAGE or TrkA with p75NTR are functionally and physically exclusive . 0.54533293^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.66916358
Immunohistomorphometry and in situ hybridization detected strong NGF and pro NGF expression in terminally differentiating inner root sheath keratinocytes , whereas TrkA was co expressed with p75NTR in basal and suprabasal outer root sheath keratinocytes . 0.66916358^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We have examined whether the low affinity neurotrophin receptor p75NTR modulates TrkA function by intracellular signaling . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Tyrosine kinase receptor ( trk ) mRNA encoding an essential component of the high affinity NGF receptor was also present at all stages . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The second NGF receptor is a member of the trk family of tyrosine kinase receptors , p140trkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Recent data indicate that the product of the trk gene , p140trk , is a critical component of the NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Messenger RNAs for trk and the low affinity NGF receptor in rat basal forebrain . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Furthermore , PC 12 mutants lacking the Trk NGF receptor tyrosine kinase also lack NGF inducible p21ras activation . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
TrkA is the NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Axonal transport of the trkA high affinity NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The present study was designed to clarify the in vivo function of trkA as an NGF receptor in mammalian neurons . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In contrast , trkA mRNA , which encodes the high affinity NGF receptor , was undetectable in either region . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The trkA protooncogene product ( p140trkA ) , a component of the NGF receptor , is not expressed by keratinocytes . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The binding of NGF delta 9 / 13 to Sf 21 cells ectopically expressing the TrkA NGF receptor was also abolished . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Developmental changes in nerve growth factor ( NGF ) binding and NGF receptor proteins trkA and p 75 in the facial nerve . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We first examined the basal forebrain tissues for developmental changes in expression of the high affinity NGF receptor ( trkA ) gene . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Analysis of the trk NGF receptor tyrosine kinase using recombinant fusion proteins . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
TrkA NGF receptor expression by non cholinergic thalamic neurons . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
This discovery suggests that the signaling NGF receptor , TrkA , can be used as a marker for nociceptive neurons . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Furthermore , colocalization studies show that many BDNF expressing sensory neurons also express trk A , the high affinity NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In contrast , the level of trkA , the NGF receptor , regulates these properties in caudate putamen cholinergic neurons . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Gene transcripts for the high affinity NGF receptor trkA were found exclusively in non germ cells . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
This down regulation does not occur in PC12nnr5 cells , which lack the p 140 ( trk ) NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Both cortical and basal forebrain explant cultures express the NGF receptor , TrkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Furthermore , bFGF induced expression of the high affinity NGF receptor ( trkA ) gene . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Mobility of TrkA is regulated by phosphorylation and interactions with the low affinity NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Here we report that activation of the TrkA NGF receptor in oligodendrocytes negates cell death by the p 75 receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To test this , double label immunohistochemistry for the NGF receptor ( trkA ) and sympathetic baskets was performed . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NGF binds to tropomyosin receptor kinase A ( TrkA ) and to 75 kDa NGF receptor ( p75NTR ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Human keratinocytes also synthesize and express the low ( p 75 ) and the high affinity ( trk ) NGF receptor ( NGF R ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The peripheral expression of trkA encoding for NGF receptor was investigated by RNase protection assay . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Intracelluar dynamics of a high affinity NGF receptor TrkA in PC 12 cell . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The C D loop in nerve growth factor ( NGF ) is involved in binding to the NGF receptor , TrkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
PS 1 protein accumulation was dose responsive to NGF and required the presence of the TrkA NGF receptor tyrosine kinase . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We have examined nerve growth factor ( NGF ) triggered signaling in two NIH3T3 cell lines exogenously expressing the NGF receptor , TrkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In contrast , no significant changes in the expression of the NGF receptor TrkA were noted under the same conditions . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Almost all BDNF mRNA expressing neurons coexpressed trkA , a high affinity NGF receptor , mRNA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
High affinity NGF receptor ( TrkA ) levels are decreased in AD brains as compared to age matched control brains . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The low affinity NGF receptor , p 75 , has long been thought merely to facilitate NGF binding to TrkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The adjacent nerves expressed the high affinity NGF receptor trk A . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The NGF receptor TrkA was found on all examined tumor cell lines and is not restricted to cells belonging to the nervous system . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Rat visual cortical neurones express TrkA NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Two classes of astrocytes in the adult human and pig retina in terms of their expression of high affinity NGF receptor ( TrkA ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In addition , we found that TrkA , the high affinity NGF receptor , was only found on fibers projecting into the barrel cortex . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Moreover , similar to previous observations in rat , the high affinity NGF receptor TrkA is also expressed in beta cells . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Autophosphorylation of NGF receptor TrkA and activation of ERK1 / 2 after NGF treatment were scarcely detected in GM1+ cells . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
TrkA is essential components of the high affinity NGF receptor necessary to mediate biological effects of the neurotrophins NGF . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
TrkA NGF receptor plays a role in the modulation of p75NTR expression . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
It has been associated with mutations in the NTRK 1 gene , located in 1q21 22 and encoding a high affinity NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NF 1 encodes a GAP for the NGF receptor TrkA , and NF 1 mutations promote survival after NGF withdrawal . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Nerve growth factor ( NGF ) contents in sciatic nerves and the expression of NGF receptor TrkA in DRGs were decreased . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Immobilization depended on the phosphorylation of the TrkA NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NGF binding to p75NGFR inhibited the toxicity of beta amyloid peptide , whereas NGF binding to TrkA , the high affinity NGFR , enhanced it . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
There was no detectable expression of high affinity tyrosine kinase receptor ( trkA ( NGFR ) ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
AEC expressed both high affinity ( TrkA ) and low affinity ( p 75 ( NGFR ) ) receptors for NGF . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Furthermore , we have compared the expression of trkA mRNA with that of the 75 kD low affinity neurotrophin receptor ( p75NTR ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Thus , without p75NTR , NT 3 substitutes for NGF , suggesting that p 75 alters the neurotrophin specificity of TrkA in vivo . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Signal transduction of nerve growth factor ( NGF ) and its TrkA and p75NTR receptors ] . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Cellular responses to NGF are facilitated by two receptors called trk A and p 75 neurotrophin receptor ( p75NTR ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The extracellular domain of p75NTR is necessary to inhibit neurotrophin 3 signaling through TrkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Inactivation of trkA , but not of p75NTR , and wortmannin prevented NGF induced p 53 nuclear translocation . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Sections were incubated with antibodies against the neurotrophin Trk receptors and p75NTR , and the neurotransmitters VIP and SP / NKA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
MGCM mediated cell death was reversed by p75NTR antiserum in p75NTR ( + ) / trkA ( ) 661w cells . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
An aging pathway controls the TrkA to p75NTR receptor switch and amyloid beta peptide generation . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
These melanoma lines express low affinity neurotrophin receptor p75NTR in relation to their brain metastatic potentials but the variants do not express trkA , the gene encoding a high affinity nerve growth factor ( NGF ) tyrosine kinase receptor p140trkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
They also express the neurotrophic protein tyrosine kinase ( Trk ) receptors TrkA , TrkB , and TrkC ; the low affinity neurotrophin receptor p75NTR ; and the glial derived neurotrophic factor receptors ( GFR ) alpha 1 , GFRalpha 2 , and GFRalpha 3 . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In this report , we demonstrate that K252a is a potent inhibitor ( IC 50 of 3 nM ) of the tyrosine protein kinase activity of the NGF receptor gp140trk , the product of the trk protooncogene . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NGF stimulated tyrosine phosphorylation of the pp140c trk NGF receptor and tyrosine phosphorylation of pp70trk are also inhibited by similar concentrations of staurosporine and K252A , whereas tyrosine phosphorylation of the EGF receptor , insulin receptor , and 5 src is not affected . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The product of the proto oncogene trk , p140trk , is a tyrosine kinase receptor that has been identified as a signal transducing receptor for NGF , while the role of the low affinity NGF receptor , p75NGFR , in signal transduction is less clear . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Exposure to RA leads neither to an increase in the expression of mRNA for trk , another component of the NGF receptor , nor to an increase in binding to high affinity receptors , suggesting that an increase in the expression of p75NGFR is sufficient to make cells more sensitive to NGF . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The cellular localization of mRNAs encoding the low affinity NGF receptor ( here referred to as LANR ) and the putative high affinity receptor for NGF , trk , have been studied in the human foetal spinal and sympathetic ganglia , and spinal cord , using in situ hybridization . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
All tissues examined coexpressed the low affinity NGF receptor ( LNGFR ) , whereas none of these tissues expressed the high affinity NGF receptor encoded by the trk protooncogene . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Colocalization of NGF binding sites , trk mRNA , and low affinity NGF receptor mRNA in primary sensory neurons : responses to injury and infusion of NGF . ^^^ The distributions of mRNAs for the protooncogene trk and the low affinity NGF receptor ( LNGFR ) were studied by hybridization with oligonucleotide probes on sections of adult rat primary sensory and sympathetic ganglia . ^^^ Among neurons in lumbar dorsal root ganglia and trigeminal ganglia , trk mRNA and NGF binding sites were closely colocalized ; this finding together with previous direct evidence in other cell types is taken to indicate that trk protein is an essential component of the high affinity NGF receptor in adult sensory neurons . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In PC 12 cells that overexpressed the tyrosine kinase encoded by the trk proto oncogene ( a component of the high affinity NGF receptor ) , the NGF induced activation of the regulatory proteins was potentiated . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Recent data have demonstrated that the product of the tyrosine kinase trk proto oncogene binds NGF and is a component of the high affinity NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
These factors utilize the Trk family of receptor tyrosine kinases , perhaps in conjunction with a second component known as the low affinity NGF receptor ( LNGFR ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
High affinity NGF binding requires coexpression of the trk proto oncogene and the low affinity NGF receptor . ^^^ Reconstitution experiments by membrane fusion and transient transfection into heterologous cells indicate that high affinity NGF binding requires coexpression and binding to both the low affinity NGF receptor and the tyrosine kinase trk gene product . ^^^ These studies reveal a new growth factor receptor mediated mechanism of cellular differentiation involving trk and the low affinity NGF receptor . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The binding of MA alpha 2M to trk , which is a part of high affinity NGF receptor , was studied with PC 12 ( 6 24 ) cells and NIH 3T3 fibroblasts expressing trk ( trk 3T3 ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
These findings suggest that the M 15 , N 60 , and 27 / 21 antibodies bind to a specific site on the surface of NGF where they competitively inhibit binding to the Trk NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Retrograde axonal transport and lesion induced upregulation of the TrkA high affinity NGF receptor . ^^^ In this study we examined the distribution and transport of the TrkA NGF receptor using two anti peptide polyclonal antibodies and a monoclonal antibody , all of which are TrkA specific . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Furthermore , such tight association of GM 1 with Trk appears to be specific , since a similar association was not observed with other growth factor receptors , such as low affinity NGF receptor ( p75NGR ) and epidermal growth factor receptor ( EGFR ) . ^^^ Thus , these results strongly suggest that GM 1 functions as a specific endogenous activator of NGF receptor function , and these enhanced effects appear to be due , at least in part , to tight association of GM 1 with Trk . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Evidence indicates that co expression of the two genes for the p 75 receptor and the Trk NGF receptor can potentially lead to greater responsiveness to NGF , and suggests additional levels of regulation for the family of neurotrophin factors . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Although multimeric complexes of trkA and p 75 were not detected by affinity crosslinking , immunoprecipitation of cross linked NGF receptor complexes with trk specific antibodies resulted in selective immunoprecipitation of crosslinked p 75 . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To begin to analyze putative relationships of growth factor responsiveness and growth factor / growth factor receptor expressions , IMR 32 , GIMEN , and LAN 1 cell lines were studied for the presence of bFGF , NGF , FGF receptors ( R ) 1 ( flg ) and FGFR 4 , trk , and low affinity NGF receptor ( p 75 ) mRNAs . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Deletion of a conserved juxtamembrane sequence ( KFG ) in the Trk NGF receptor resulted in impaired neurite outgrowth , somatic hypertrophy , and induction of c fos , c jun , and TIS 1 immediate early genes . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The ovary also expresses some of the neurotrophin receptors , including p 75 NGFR , trkB [ the receptor for NT 4 / 5 and brain derived neurotropic factor ( BDNF ) ] , and trkA ( the NGF receptor ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In situ hybridization studies confirmed that the high affinity BDNF receptor ( TrkB ) was much more widely expressed in neurons than was the high affinity NGF receptor ( TrkA ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In mutant PC 12 nnr 5 cells that lack the Trk NGF receptor , the purine analogue sensitive p 75 associated kinase activity was not inducible by NFG . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We document the presence of RNA message for the low ( LNGFR ) and the high affinity NGF receptor ( NTRK 1 ) by using RT PCR on fresh BM aspirate and on LTBMC . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Because of the synergistic effects of DHT and NGF , the regulation of NGF receptor mRNA by DHT was evaluated ; however , no significant induction of either trkA or p 75 mRNA expression by androgen was documented . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In contrast , expression of mRNAs encoding choline acetyltransferase , p 75 low affinity NGF receptor , neurotrophin tyrosine kinase receptors Trk and TrkB , and brain derived neurotrophic factor showed neuronal sparing in several other regions of the brain . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In this study , we analyzed the NGF level in wound fluid by a sensitive enzyme immunoassay and correlated the NGF level with the cytological localization of NGF , low affinity NGF receptor ( p75NGFR ) , and Trk receptor in the axotomized nerve by immunohistochemistry . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NGF mediated neuronal differentiation was observed solely in trkA expressing B 104 derived clones and was characterized by reduced cell growth , activation of NGF regulated genes , and downregulation of the endogenous low affinity NGF receptor gene ( gp75NGFR ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We have demonstrated the expression of Trk A messenger RNA coding for the high affinity NGF receptor in islet cells and the localization of Trk protein in both alpha and beta islet cells . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In this report we have characterized the expression of the signal transducing component of the NGF receptor , the Trk tyrosine receptor kinase , in prostate epithelial cells that bind exogenous NGF beta and an endogenous NGF beta immunoreactive protein in hPS . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
PNT 1 was shown to efficiently block the chemical crosslinking of NGF , BDNF , and NT 3 to their cognate Trk receptors and to the low affintiy NGF receptor expressed on neuronal and nonneuronal cells . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
It was previously demonstrated that the high affinity NGF receptor , Trk A , which is sufficient for NGF signal transduction , is expressed in different beta cell lines and in normal rat islet cells in primary culture . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Our findings indicate that GM 1 promoted survival can be mediated in part by the Trk NGF receptor as well as by TrkB , and potentially by tyrosine kinase receptors for additional neurotrophic growth factors . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Colocalization studies revealed that between 66 % and 76 % of trk immunoreactive basal forebrain neurons also expressed immunoreactivity for the low affinity p 75 NGF receptor , an excellent marker for cholinergic basal forebrain cells . ^^^ In this experiment , most single labeled basal forebrain neurons contained only trk immunoreactivity , whereas 4 % of basal forebrain neurons expressed only the low affinity p 75 NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Our findings indicate that C 6 2B glioma cells do not possess high affinity NGF receptor and thus are unresponsive to NGF and that expression of trkA in neuroectoderm derived cells elicits some of the NGF responses characteristic of neuronal cells . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Maximal inhibition of VGF mRNA induction was achieved using K 252a , an inhibitor of the NGF receptor Trk tyrosine kinase , and by mutating both Y 490 ( SHC association site ) and Y 785 ( PLC gamma 1 association site ) of Trk . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Immunohistochemical localization of the high affinity NGF receptor ( gp 140 trkA ) in the adult human dorsal root and sympathetic ganglia and in the nerves and sensory corpuscles supplying digital skin . ^^^ Recently , a protein tyrosine kinase of congruent to 140 kDa molecular weight , encoded by the proto oncogene trkA , has been identified as the high affinity NGF receptor ( gp 140 trkA ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The detection of relatively high amounts of NGF synthesis in the BF S was supported in studies demonstrating rapid NGF receptor ( Trk ) activation in the basal forebrain by exogenous NGF and in experiments showing that NGF mRNA was inducible in the BF S by 1 , 25 dihydroxyvitamin D 3 . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In the present study , we used immunocytochemistry to show that the high affinity NGF receptor protein , gp140trk ( trk ) is detectable in embryonic spinal tissue sections and in cord dissociates . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We have analyzed murine CD4+ T cell clones for their ability to express transcripts encoding NGF , low affinity NGF receptor , and trk protooncogene , the signal transducing receptor subunit for NGF . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In NGF binding studies using anti trkA and anti low affinity NGF receptor ( LNGFR ) immunoglobulin ( Ig ) G , essentially all binding of NGF can be inhibited . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We now report that melanocyte stimulation with phorbol 12 tetra decanoate 13 acetate ( TPA ) , previously reported to induce p 75 NGF receptor , also induces trk in melanocytes , and TPA effect is further potentiated by the presence of keratinocytes in culture . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The potency of binding of all hNGF variants to the low affinity NGF receptor p 75 was largely unaffected indicating distinct structural contributions of the NH 2 terminal region of hNGF to the binding to TrkA versus p75 . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
While Shc is also found bound to the activated NGF receptor , Trk , no complexes were detectable that contained both Trk and Grb 2 or Sos . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Function perturbing antibodies to the p 75 low affinity NGF receptor potentiated the NT 3 responses of both forms of TrkA in the transfected PC12nnr5 cell lines , suggesting that the low affinity NGF receptor suppresses the ability of TrkA to respond to NT 3 . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Clinical response to retinoic acid was noted only in the two children with tumors coexpressing trk protooncogene mRNA , encoding an essential part of the nerve growth factor ( NGF ) high affinity receptor , and low affinity NGF receptor gene ( LNGFR ) mRNA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Using in situ hybridization and immunohistochemistry , we now show that the expression of this receptor is selectively concentrated in a subset of neurons where its appearance is closely associated with that of the NGF receptor TRK . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
High levels of BDNF transcripts were observed in the sensory epithelia of all vestibular end organs . mRNAs of low affinity NGF receptor , trkB and trkC , but not of trk , were expressed in the spiral and vestibular ganglia . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Immunocytochemical staining of C 6 cells with antibodies directed against either the low affinity NGF receptor gp75NGFR or trk proto oncogene products demonstrated a heterogeneous cellular distribution of both antigens . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Expression and functionality of the trkA proto oncogene product / NGF receptor in undifferentiated hematopoietic cells . ^^^ The expression of the low affinity NGF receptor ( p 75 ) and the trkA proto oncogene product was analyzed in a series of human hematopoietic cell lines at protein and RNA levels . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Our findings that neither mitogen nor Ag stimulation induced the expression of the low affinity NGF receptor in 9 / 6 T cells indicate that trk alone is sufficient to mediate biologic activity of NGF in T lymphocytes . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NGF promotes neurite outgrowth and proliferation from such cells , indicating that Trk is sufficient to mediate such responses in the absence of significant levels of the endogenous 75 kDa low affinity NGF receptor ( p 75 ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
If this is the case , neurons in the prevertebral ganglia should express another neurotrophin receptor , in addition to the NGF receptor ( trkA ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
On the other hand , expression of the high affinity NGF receptor ( trkA ) is restricted to cholinergic neurons in basal forebrain and striatum . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The biological responsiveness of neural cells to nerve growth factor ( NGF ) appears to require expression and ligand binding to both the low affinity NGF receptor ( LNGFR ) and the proto oncogene product trk , the latter being a receptor tyrosine kinase . ^^^ Immunolocalization of the LNGFR and the high affinity component of the NGF receptor , trk ( HNGFR ) was studied by electron microscopic morphometric analysis on cultured PC 12 pheochromocytoma cells , C 6 glioma cells and neonatal rat dorsal root ganglia neurons using a double immunogold labeling technique . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Several lines of evidence suggest that NGF is also the ligand for trkE ; ( 1 ) normal human keratinocytes bind NGF with high affinity , ( 2 ) NGF stimulates keratinocyte growth in an autocrine fashion , ( 3 ) NGF exerts its biological effect on keratinocytes through the stimulation of a trk specific tyrosine kinase , and ( 4 ) keratinocytes lack trkA but do express large amount of trkE . trkE might also be the NGF receptor by other human peripheral tissues , such as pancreatic islets , and might represent a non neuronal receptor for this ligand . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Thus , trkA expression in HTLA 230 cells is sufficient to generate a functional NGF receptor complex that leads to growth arrested and differentiated NB cells in vitro and in vivo in the presence of NGF . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We have investigated the role of trkA , the tyrosine kinase NGF receptor , in mediating the survival response of embryonic neurons to NGF . ^^^ The failure of trkA to result in an NGF promoted survival response in ciliary neurons is not due to absence of the low affinity NGF receptor , p 75 , in these neurons . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In situ hybridization and image analysis were then used to determine neuronal levels of p 75 NGF receptor , trkA , and T alpha 1 alpha tubulin mRNAs , with the latter providing a correlative measure of neuronal sprouting . ^^^ These data therefore suggest that , in addition to promoting local sprouting , increased target derived NGF increases the levels of p 75 NGF receptor relative to trkA on terminal neurites , by differentially regulating receptor synthesis . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Since previous studies have shown that these three neurotrophins bind to the low affinity NGF receptor , p75NGFR , with similar affinity , our data suggest that the retrograde transport of neurotrophins by motoneurons may be mediated by additional components , such as the trk family of proto oncogenes . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In contrast , although the mRNAs for the NGF receptors p75NGFR and trkA were also expressed in DRG neurons from OVX and intact animals , expression of both NGF receptor mRNAs was upregulated in sensory neurons during proestrus , as compared to the OVX condition . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Trk immunoreactivity was observed in basal forebrain and striatal cholinergic neurons , whereas low affinity NGF receptor immunoreactivity was observed in basal forebrain but not striatal cholinergic neurons . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In contrast to TrkA , the high affinity NGF receptor that transduces NGF signals for survival and differentiation , the function of the low affinity NGF receptor , p75NGFR , remains uncertain . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The neuron like differentiation of PC 12 cells is induced by nerve growth factor ( NGF ) through stimulation of a membrane bound protooncoprotein signaling pathway containing the NGF receptor Trk , the tyrosine kinase Src , and the GTP binding protein Ras . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Expression of mRNA for the trk protooncogene , encoding a tyrosine kinase receptor essential for functional NGF signal transduction , and mRNA for the low affinity NGF receptor ( LNGFR ) was examined in 45 neuroblastomas and 3 benign ganglioneuromas using Northern blot analysis . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The retinoid produced a two to threefold increase in level of p75LNGFR mRNA ( the low affinity NGF receptor ) , without altering expression of the trk protoon cogene ( the high affinity NGF receptor carrying tyrosine kinase activity ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We now report that trkA , the NGF receptor tyrosine kinase , is involved in the acute activational process that leads to the first ovulation . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We have investigated the role of trkA , the tyrosine kinase NGF receptor in mediating the survival response of embryonic chicken neurons to NGF . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Our cellular data support the concept that staurosporine acts to inhibit the NGF receptor Trk ( Nye et al . : Mol Biol Cell 3 : 677 686 , 1992 ) , but that downstream steps can be activated by the higher concentration of staurosporine to bypass Trk and lead to neurite generation . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Support for the latter hypothesis comes from our recent observations of co expression of estrogen receptor mRNA with the mRNAs for the neurotrophins and their receptors ; differential and reciprocal up regulation of estrogen and NGF receptor mRNA and protein expression by estrogen in adult female rat sensory neurons , PC 12 cells ; and cerebral cortical cultures ; and putative estrogen response elements in the NGF , BDNF , trkA and p 75 genes . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The high affinity NGF receptor is thought to be a complex of two receptors , gp 75 and the tyrosine kinase TrkA , but direct biochemical evidence for such an association had been lacking . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We performed high sensitivity flow cytometry and Western blotting to study the expression of the low affinity NGF receptor ( p75NGFR ) and of the transmembrane tyrosine kinase ( Trk ) family of high affinity receptors for the different neurotrophic factors on Epstein Barr virus ( EBV ) transformed human B lymphocytes . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In agreement with this result , the mRNA encoding the low affinity NGF receptor ( LNGFR ) was detected in ROS 17 / 2 . 8 cells , unlike trkA transcripts which encode the high affinity receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
HTLA 230 , an NB cell line isolated from a patient with advanced disease , and its NGF receptor ( trkA ) expressing derivative ( 18 10 ) cells , consistently disseminated to the liver , the adrenal gland , and the bone marrow , but not the lungs . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The high affinity NGF receptor , trkA , is selectively expressed by nociceptive sensory neurons particularly those containing sensory neuropeptides such as substance P and CGRP . 4 . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The situation is complex , however , in that NT 3 ( / ) mutant mice show far greater neuron loss than mice deficient in the NT 3 receptor TrkC , suggesting that NT 3 may support many DRG neurons via actions on the NGF receptor TrkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
This study examines how the family of neurotrophin receptor tyrosine kinases ( Trks ) participates in the regeneration and replacement of olfactory neurons within the adult rat olfactory neuroepithelium . mRNA and protein products representing the high affinity nerve growth factor ( NGF ) receptor Trk A , its family members Trk B and Trk C , and the low affinity NGF receptor ( INGFR ) are all detected within both mature and regenerating olfactory neuroepithelium and within primary cultures of olfactory neurons . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Nerve growth factor ( NGF ) added to SH SY5Y cells stably transfected with the NGF receptor TRK A ( SH SY5Y / trk ) induces a similar differentiated phenotype . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To test the molecular nature of the NGF receptor responsible for the ability of NGF to rescue septal cholinergic neurons following axotomy , we infused polyclonal antibodies that act as specific agonists of trkA ( RTA ) into the lateral ventricle of fimbria fornix lesioned animals . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The contribution of nerve growth factor ( NGF ) to inflammatory hyperalgesia potentially could be mediated by any of the three peripheral cell types that express trkA , the high affinity NGF receptor : inflammatory cells , sympathetic neurons , and primary sensory neurons . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
TrkC , the high affinity NT 3 receptor , and trkA , the high affinity NGF receptor , are both expressed from the early OLP through the mature OL stage . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We have found evidence that part of the survival promoting activity of GM 1 is dependent on the presence , dimerization , and activation of the Trk NGF receptor tyrosine kinase and that GM 1 causes a detectable increase in Trk receptor autophosphorylation . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Postnatal changes in the expression of the trkA high affinity NGF receptor in primary sensory neurons . ^^^ In development approximately 70 80 % of dorsal root ganglion ( DRG ) cells are dependent on nerve growth factor ( NGF ) for their survival , while in the adult only some 40 % of DRG cells express the high affinity NGF receptor , trkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
It is , however , unknown whether other homologous neurotrophins also act outside the nervous system , and whether activation of basophils by NGF requires interaction with trk tyrosine kinase receptors , the low affinity NGF receptor ( LNGFR ) , or both . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Human recombinant NGF mediated phosphorylation of a 140 kDa Trk NGF receptor in the TSU pr 1 cell line was inhibited by treatment with 100 nM K252a . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The mechanism ( s ) underlying nerve growth factor ( NGF ) mediated rescue of neurons from apoptosis is poorly understood , although it is well established that the high affinity NGF receptor ( TrkA ) plays a pivotal role in mediating NGF effects . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We have studied the postnatal expression of neurotrophins , their cognate high affinity trk receptors and the low affinity NGF receptor ( p75LNGFR ) in the rat adrenal gland using RT PCR . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
These results suggest that the NGF effect is mediated by the high affinity NGF receptor , Trk A and that neurotrophin binding to the low affinity neurotrophin receptor , p 75 ( NTR ) , alone does not affect the promoter activity . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Inhibition of neuronal differentiation is accompanied by significant changes in the protein and mRNA expression pattern of the high affinity NGF receptor ( trkA ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To examine their roles in the TRK NGF receptor , these residues ( Tyr 670 , Tyr 674 , and Tyr 675 ) were mutated singly and in all combinations to phenylalanine and stably expressed in Trk deficient PC12nnr5 cells . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Using an oxidation sensitive compound , dihydrorhodamine , we measured ROS formation in a central nervous system derived neuronal cell line ( GT 1 1 trk ) and in superior cervical ganglion neurons , both of which express the transmembrane NGF receptor tyrosine kinase , trkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
A role for the local activation of the high affinity NGF receptor trkA was suggested by a strong inhibition of the turning response by ( 1 ) the addition of an antibody against the extracellular portion of trkA , ( 2 ) the elevation of the background concentration of NGF to saturate trkA , or ( 3 ) the presence of a concentration of the drug K252a that inhibits trkA activation . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Intracellular application of a phosphopeptide , Trk 490 , which prevents the binding of the adaptor protein shc to the activated NGF receptor , so blocking p 21 ras activation , reduced 1 ( max ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To identify nerve growth factor ( NGF ) target cells in normal and pathologic human lymphoid tissues , we have studied the expression of the low affinity NGF receptor ( p75LNGFR ) and the high affinity tropomyosin related kinase NGF receptor ( TrkA ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
This study examined whether ethanol exposure of the neonatal rat cerebellum altered the levels of either NGF or the expression of p 75 and trkA , which are two components of the NGF receptor . ^^^ Immunohistochemical labeling techniques indicated that both the p 75 and trkA NGF receptors were expressed on Purkinje cell dendrites in the developing cerebellum , with posterior lobules expressing higher levels of p 75 and trkA NGF receptor , compared with anterior lobules . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Nerve growth factor ( NGF ) treatment of rat PC 12 pheochromocytoma cells results in an increase in the tyrosine phosphorylation of the NGF receptor , TrkA , leading to differentiation to a neuronal phenotype . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
RESULTS : Our data have shown that in unstimulated conditions , human CD4+ T cell clones express both immunoreactivity for NGF and the TrkA NGF receptor irrespective of their cytokine profile . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To determine if human mast cells express the NGF receptors , TrkA tyrosine receptor and the low affinity NGF receptor ( LNGFR ) , we first analyzed the mRNA expression by RT PCR of TrkA and LNGFR in a human mast cell line ( HMC 1 ) and in human mast cells cultured in the presence of stem cell factor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Steady state expression of transcripts for neurofilament ( NF ) proteins ( NF L , NF H ) and the high affinity NGF receptor , trkA was decreased by diabetes in the contralateral ganglia to the crush ( all P < 0 . 05 ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The present data give evidence for the expression of TrkA , the so called high affinity NGF receptor , and of p75NTR , the so called low affinity NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We have investigated the expression of the signal transducing NGF receptor trkA on mRNA and protein level during development of chick sympathetic neurons obtained from lumbosacral , paravertebral chain ganglia between embryonic days ( E ) 6 . 5 and 10 . ^^^ These data provide evidence that sympathetic neurons upregulate the NGF receptor trkA and in this way acquire NGF dependency . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The fact that increased nerve growth factor ( NGF ) protein levels were found throughout brains of Alzheimer ' s disease patients led us to investigate neurotrophin synthesis in a human microglial cell line showing typical properties of human microglial cells , including expression of neurotrophins such as NGF , as well as the NGF receptor trkA and the low affinity neurotrophin receptor p 75 . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The neurotrophic activity of APP was independent of the TrkA NGF receptor because neither phospholipase C gamma 1 nor TrkA exhibited tyrosine phosphorylations with APP treatment . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Neurotrophin expression was not unique to adult tissues since pancreatic cells transiently expressed p 75 , the NGF receptor Trk A , and NGF during development . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To clarify the role of the common neurotrophin receptor p 75 in modulating the survival response of sensory and sympathetic neurons to NGF at different stages of development , we compared the actions of wild type NGF with a mutated NGF protein that binds normally to TrkA , the NGF receptor tyrosine kinase , but has greatly reduced binding to p 75 . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Next , we investigated the tyrosine phosphorylation of NGF receptor TrkA and the EGF receptor ( EGFR ) as well as mitogen activated protein kinase ( MAPK ) , which is a key protein in the intracellular signal transduction pathway . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
As determined by transient expression , two NGF response elements ( REs ) were required for transcription induced by NGF in SH SY5Y cells with stable expression of an exogenous NGF receptor TRK A gene ( SH SY5Y / trk ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In addition , our results show that MKP 1 mRNA is induced after NGF stimulation of fibroblasts expressing the NGF receptor TrkA , suggesting that MKP 1 is upregulated after activation of the TrkA receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The in vivo targeting efficacy of small molecule analogs of nerve growth factor ( NGF ) that bind the NGF receptor p 140 TrkA was evaluated and compared with that of a high affinity anti TrkA monoclonal antibody ( Mab 5C3 ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In contrast , human bone marrow cells consistently expressed mRNA for trkB ( the BDNF and NT 4 receptor ) and displayed variable expression of mRNA coding for trkA ( the tyrosine kinase NGF receptor ) and LNGFR ( the low affinity NGF receptor ) , whereas mRNA for trkC ( the NT 3 receptor ) was not expressed . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Using the mice which had received unilateral olfactory bulbectomy and in which antibodies to NGF had been continuously infused with into the contralateral olfactory blub , three kinds of analysis were performed : histological analysis of the olfactory epithelium by HE staining , immunohistochemical analysis of the olfactory epithelium using polyclonal antibodies to trk which forms the NGF receptor , and olfactory mediated behavioral analysis with cycloheximide . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Our previous studies have shown that cholera toxin B subunit , which specifically binds to the cell surface ganglioside GM 1 , and GM 1 itself can enhance the action of nerve growth factor ( NGF ) in responsive cells by enhancing the NGF induced autophosphorylation of the high affinity NGF receptor , Trk . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Two types of receptors mediate the actions of these polypeptides : the Trk family of tyrosine kinase receptors and the so called p 75 low affinity NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Furthermore , the high affinity NGF receptor ( TrkA ) was found at both the transcriptional and protein levels , while expression of the low affinity NGF receptor was detectable at the mRNA level only . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Recent experiments with NGF responsive cells revealed a specific role for the high affinity NGF receptor , TrkA , in the increases in secretory APP processing and a role for the low affinity neurotrophin receptor , p75NTR , in the transcriptional regulation of APP . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The reverse transcription polymerase chain reaction , immunocytochemical staining , and Western blotting revealed that cultured microglia express Trk A , B , and C , and low affinity NGF receptor , LNGFRp 75 . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We have studied the high affinity NGF receptor TrkA , during the regeneration of the tench ( Tinca tinca L . ) optic nerve , using immunocytochemical techniques . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Like suramin and NGF , PPS induced neurite outgrowth from the PC 12 cell line which correlated with tyrosine phosphorylation of the high affinity NGF receptor ( TrkA / gpl40 ) and ERK 1 / MAP kinase . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We have tested the localization and the molecular nature of the NGF receptor ( s ) responsible for this effect by activating cortical trkA receptors in monocularly deprived rats by cortical infusion of a specific agonist of NGF on trkA , the bivalent antirat trkA IgG ( RTA IgG ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Within this population , VR 1 mRNA is detected at widely varying levels in both the NGF receptor ( trkA ) positive , peptide producing cells that elicit neurogenic inflammation and the functionally less characterized glial cell line derived neurotrophic factor responsive cells that bind lectin Griffonia simplicifolia isolectin B 4 ( IB 4 ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The present study examined the effect of long term ( 90 days ) daily injections of an estrogen preparation , Premarin ( Wyeth Ayerst , Radnor , PA ) , to ovariectomized adult rats on lumbar DRG high affinity NGF receptor , trkA , mRNA levels , and on beta preprotachykinin ( beta PPT ) mRNA levels , which have been shown to be regulated by NGF . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The aim of the present study was , using an antibody specific to the high affinity NGF receptor ( trkA ) , to examine immunohistochemically the distribution of the NGF receptor in the mouse olfactory tract , under normal conditions and during regenerative processes . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
When human trk A cDNA was transfected into a human glioma cell line , U 251MG , which lacks expression of both endogenous trk A and low affinity NGF receptor , the transfectant expressed the exogenous trk A mRNA and a functional high affinity NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To investigate a putative role of nerve growth factor ( NGF ) in central plasticity linked to chronic pain , modifications in immunoreactivity ( IR ) for the high affinity NGF receptor , TrkA , were studied at spinal levels in a rat model of inflammatory chronic pain , adjuvant induced arthritis ( AIA ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Whereas the N 4 , L 38 , and NGFbeta peptide domains present within pro NGF were previously shown to induce phosphorylation of the high affinity NGF receptor , tropomyosin receptor kinase ( Trk ) , only the NGFbeta moiety was able to stimulate anchorage independent growth of prostate tumor cells . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To determine whether this action of NGF is mediated by the p140TrkA NGF receptor ( a member of the Trk tyrosine kinase family ) we used a murine basal forebrain cholinergic cell line , SN 56 , stably transfected with rat trkA cDNA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Identical results were obtained when a specific agonist of the NGF receptor TrkA , the bivalent anti rat TrkA IgG ( RTA ) , was infused into the cortex in place of NGF . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To understand the mechanism of neurotrophin stimulated calcium uptake , the regulation of calcium uptake and intracellular mobilization by nerve growth factor ( NGF ) was investigated using NIH 3T3 cells stably transfected with either the high affinity NGF receptor p 140 ( trk ) ( 3T3 Trk ) or the low affinity NGF receptor p 75 ( NGFR ) ( 3T3 p 75 ) . ^^^ These studies show that either NGF receptor will support increases in intracellular calcium but that p 140 ( trk ) does so by increasing both uptake and mobilization , whereas p 75 ( NGFR ) does so by increasing uptake only . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
SH 2 B has been shown to be required for nerve growth factor ( NGF ) mediated neuronal differentiation and survival , associate with NGF receptor TrkA , and be tyrosyl phosphorylated in response to NGF . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NGF receptor ( TrkA and p75NGFR ) expression was investigated in human thymuses , including normal thymuses , thymic hyperplasias , thymomas and thymic carcinomas . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The ganglioside GM 1 is known to protect neuronal cell lines from apoptosis induced by serum / growth factor withdrawal and its effect is mediated in part by the direct activation of the trkA NGF receptor [ G . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The trkA proto oncogene encodes a high affinity NGF receptor that is essential for the survival , differentiation and maintenance of many neural and non neural cell types . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Human monocytes / macrophages ( M / M ) infected in vitro with HIV type 1 ( HIV 1 ) are able to produce substantial levels of NGF that are associated with enhanced expression of the high affinity NGF receptor ( p 140 trkA ) on the M / M surface . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To define cellular mechanisms that modulate A ( 2A ) AR expression , A ( 2A ) AR mRNA and protein levels were examined in three PC 12 sublines : 1 ) PC12nnr5 cells , which lack the high affinity NGF receptor TrkA , 2 ) srcDN 2 cells , which overexpress kinase defective Src , and 3 ) 17 . 26 cells , which overexpress a dominant inhibitory Ras . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Anandamide ( ANA ) inhibits prolactin and nerve growth factor ( NGF ) induced proliferation of human breast cancer cells by decreasing the levels of the 100 kDa prolactin receptor ( PRLr ) and the high affinity trk NGF receptor , respectively , and by acting via CB ( 1 ) like cannabinoid receptors . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To investigate further its possible mode of action , the ability of monoamine activated alpha1M and normal alpha1M to bind and to activate the NGF receptor ( TrkA ) was investigated . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Moreover , the results showed that the optic nerves also expressed trkA NGF receptor and NGFmRNA , most likely by oligodendrocytes , implying that NGF is locally produced and suggesting that the presence of NGF might be regulated by an autocrine mechanism . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
While FGFR 1 interacts with FRS 2 constitutively , independent of ligand stimulation and tyrosine phosphorylation , NGF receptor ( TrkA ) binding to FRS 2 is strongly dependent on receptor activation . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
However , during development precursors to rat sympathetic neurons in the thoracolumbar region are not responsive to NGF because they lack the signal transducing NGF receptor , trkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
TrkA , the NGF receptor tyrosine kinase , was expressed in the nodose ganglion throughout development and there was a marked decrease in TrkA mRNA expression in the nodose ganglion of NGF / embryos . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Only the TrkA and not the p 75 NGF receptor was detected at m RNA and protein level , and only the TrkA NGF receptor was up regulated during NGF driven culture . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To study peripheral neuron development in the absence of neurotrophin signaling , we have generated mice that are double null for BAX and nerve growth factor ( NGF ) , and BAX and the NGF receptor TrkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In conjunction , evidence of reduced sympathetic innervation in the failing heart was apparent , as measured histologically by catecholamine fluorescence and by expression of the neuronal NGF receptor trkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Wild type SH SY5Y cells are unresponsive to nerve growth factor ( NGF ) , but cells transfected with the high affinity NGF receptor TrkA ( SH SY5Y / TrkA ) differentiate in response to NGF . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The discoidin domain receptor ( DDR 1 ) is characterized by a discoidin 1 motif in the extracellular domain , an unusually long cytoplasmic juxtamembrane ( JM ) region , and a kinase domain that is 45 % identical to that of the NGF receptor , TrkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The authors demonstrate for the first time the immunocytochemical expression of the low affinity neurotrophic growth factor ( NGF ) receptor p75LNGFR and the high affinity NGF receptor trkA in the human testis . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To test this hypothesis , we measured NGF content and NGF receptor expression , p 75 ( NTR ) ( low affinity neurotrophin receptor ) and trkA ( high affinity NGF receptor ) , in control and diabetic rat SMG , CG and superior cervical ganglia ( SCG ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In this study , we show that triggering of the high affinity NGF receptor TrkA with agonists protects monocytes from apoptosis induced by gliotoxin or UVB radiation . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Moreover , combined deep etching and immunogold techniques revealed the presence of the NGF receptor TrkA in the caveolae of PC 12 cells . ^^^ Taken together , our results demonstrate the presence of caveolae in PC 12 cells , which contain the high affinity NGF receptor TrkA , and the specific involvement of these cholesterol enriched plasma membrane microdomains in the propagation of the NGF induced signal . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
TRK T 1 oncogene is generated by the rearrangement of the NGF receptor TrkA with TPR . ^^^ TRK T 1 oncogene is generated by the rearrangement of the NGF receptor TrkA with TPR . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Nerve growth factor ( NGF ) regulates the nociceptive properties including sensitivity to capsaicin of a subset of dorsal root ganglion neurons , which express the high affinity NGF receptor , trkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The TrkA NGF receptor extracellular region contains three leucine repeats flanked by cysteine clusters and two immunoglobulin like domains that are required for specific ligand binding . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Dorsal root ganglion ( DRG ) neurons that mediate nociception express the high affinity NGF receptor ( trkA ) gene and the preprotachykinin ( PPT ) gene . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
This effect is mediated by the activation of the NGF receptor TrkA because the specific inhibitor of Trk phosphorylation K252a also blocks NGF induced increase in insulin secretion , both in the presence and absence of exogenous NGF . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
At E 17 , almost all Na ( 5 ) 1 . 8 expressing neurons also express the high affinity NGF receptor TrkA , and only a small proportion bind to IB 4 , a marker for c ret expressing ( glial derived neurotrophic factor responsive ) neurons . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To further examine this assertion in vivo , we have studied two populations of NGF dependent neurones during the period of naturally occurring neuronal death in mice that lack BAX , NGF or the NGF receptor TrkA , alone and in combination . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The NGF receptor trkA is a tyrosine kinase receptor comprising an extracellular domain with a ligand binding site , a transmembrane spanning domain ( TMD ) , and an intracellular domain composed of a juxtamembrane region ( JMR ) , a tyrosine kinase domain , and a short carboxy terminal tail . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
CONCLUSION : Restoration of high affinity NGF receptor ( trkA ) expression in neuroblastoma cells could induce non reversal differentiation . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Inhibitors of phosphatidylinositol 3 kinase ( LY 294002 ) , mammalian target of rapamycin ( rapamycin ) , and the NGF receptor , TrkA ( K 252a ) , but not of mitogen activated protein kinase ( PD 98059 ) , prevented the recruitment of eEF1A 1 mRNA to polyribosomes . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The p 75 low affinity neurotrophin receptor ( p 75 ( LNTR ) ) appears to have various functions that include enhancing nerve growth factor ( NGF ) mediated survival by increasing TrkA ( high affinity NGF receptor ) efficiency , and mediating apoptosis by acting as a ligand regulated pro apoptotic receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
This response reached maximal levels as early as 5 min after the initiation of the coincubation and was completely blocked by anti NGF Ab or by an inhibitor for a tyrosine kinase of the trkA NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In addition , the effect of albumin seemed to depend on the activity of the NGF receptor , TrkA , suggesting that the glutamate synthesized and released due to the presence of albumin promotes neuronal survival through the activity of TrkA . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
PURPOSE : To determine the presence of nerve growth factor ( NGF ) , NGF mRNA , and NGF receptor ( TrkA ) in rabbit ocular tissues , and whether changes occur in NGF and NGF mRNA levels after experimental iridectomy . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Pharmacological and dominant negative inhibition and kinase assays indicate that Bgamma promotes neuritogenesis by stimulating the MAP kinase cascade downstream of the TrkA NGF receptor but upstream or at the level of the B Raf kinase . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The expression level of TrkA in PC 84 cells was comparable to that in PC 12 cells ; whereas that of another NGF receptor , p 75 , was significantly lower . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
RESULTS : We found that RA increased the expression of both trkA and p 75 NGF receptors in NCI N 592 and GLC 8 cell lines and prevented the loss of both NGF production and NGF receptor expression occurring when NGF treatment was discontinued . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Adrenergic mouse pheochromocytoma ( MPC ) cells from heterozygous neurofibromatosis knockout mice show little or no expression of the NGF receptor trk A and do not undergo neuronal differentiation in response to NGF . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Increased expression of nerve growth factor ( NGF ) and high affinity NGF receptor ( p 140 TrkA ) in human osteoarthritic chondrocytes . ^^^ OBJECTIVE : We aimed to investigate the expression of nerve growth factor ( NGF ) and high affinity NGF receptor ( p 140 TrkA ) on chondrocytes from human healthy and osteoarthritic cartilage . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In the older GK rats , both mRNA and protein expression of nerve growth factor ( NGF ) in the sciatic nerve were significantly reduced ( p < 0 . 001 and p < 0 . 05 ) , and NGFR TrkA ( high affinity NGF receptor ) and NGFRp 75 ( low affinity NGF receptor ) protein expression was reduced in dorsal root ganglia ( DRG ) ( both p < 0 . 05 ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
RESULTS : These results revealed a low amount of NGF in the plasma of old subjects associated with a reduced expression of mRNA for NGF receptor trkA in peripheral lymphocytes . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Pathways responsible for transducing the sensitisation of TRPV 1 by TrkA , the NGF receptor , were characterised by observing the effects of inhibitors of key members of NGF activated second messenger signalling cascades . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Here we show that survival of sympathetic neurons supported by NGF on distal axons requires the kinase activity of the NGF receptor , TrkA , in both distal axons and cell bodies . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
METHODS : Retroviral vectors were constructed to express the high affinity NGF receptor ( TrkA ) and low affinity NGF receptor ( p 75 ( NTR ) ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Quantitative in situ hybridization was used to detect changes in neuronal PACAP mRNA expression and to correlate this expression with neuronal mRNA expression of the NGF receptor tyrosine kinase ( trk ) A . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Previous studies have shown that the activation kinetics of the NGF receptor , TrkA , and downstream protein kinases appear rapid and seemingly transient after NGF treatment of naive PC 12 cells . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Importantly , the constitutive growth of breast cancer cells was strongly inhibited by either NGF neutralizing antibodies or K 252a , a pharmacological inhibitor of NGF receptor TrkA , indicating the existence of an NGF autocrine loop . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
METHODS : Rat lenses were dissected and the expression of NGF , NGF mRNA and high affinity NGF receptor ( TrkA ) was evaluated by immunohistochemistry , immunoenzymatic assay ( ELISA ) and in situ hybridization ( ISH ) techniques . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Finally , levels of TrkA NGF receptor in sensory neurons of T 13 and L 1 dorsal root ganglia ( DRG ) , which supply the uterus , were assessed using densitometric immunohistochemistry . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NGF protein levels in the culture medium , NGFmRNA and high affinity NGF receptor ( Tyrosine kinase A : TrkA ) expression in the cells were evaluated in basal conditions and after stimulation with pro inflammatory cytokines or with the neuropeptide cholecystokinin 8 ( CCK 8 ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In B5P cells , a clonal cell line of PC 12 cells overexpressing tyrosine kinase NGF receptor ( TrkA ) , cPA elicited transphosphorylation of TrkA . cPA elicited ERK activation was blocked by K252a and PKI . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We show here that their respective receptors , TrkA , TrkB , TrkC , as well as p 75 ( NTR ) ( the low affinity NGF receptor ) , are expressed in vitro by the nasal ensheathing cells ; the three neurotrophins promote purification and proliferation of these glial cells , with an optimal concentration of 50 ng / ml ; and human ensheathing cells can be easily biopsied and highly purified using a serum free medium supplemented with NT 3 . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In PC 12 cells , it activated the high affinity NGF receptor , TrkA , and displayed NGF like bioactivity by promoting neurite outgrowth and cell survival after serum deprivation . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The pharmacological inhibition of phosphatidylinositol 3 kinase ( PI3K ) by wortmannin significantly suppressed the survival supporting activity of MC 14 , whereas the NGF receptor ( tyrosine kinase A or TrkA ) inhibitor K252a showed no detectable effect on MC 14 activity . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The objective of the present report was to study the expression of the low affinity nerve growth factor ( NGF ) receptor p 75 and of the activated high affinity NGF receptor TrkA in malignant mesothelioma ( MM ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Gene expression of NGF and its high affinity receptor ( TrkA ) are reduced in tumour tissues , whereas the number of cells immunopositive to the low affinity NGF receptor ( p 75 ) is increased . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We have now detected , by immunohistochemistry , beta 3 subunits in 82 % of small / medium and 67 % of large diameter sensory neurons in intact human dorsal root ganglia : 54 % of beta 3 small / medium neurons were NGF receptor trkA negative . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
It activated NGF receptor , TrkA and its downstream signaling pathways in PC 12 and promoted the survival of neuronally differentiated PC 12 cells deprived of serum . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The peptide activated signal transduction pathways of the NGF receptor TrkA in PC 12 cells and supported the survival of the cells after serum deprivation . ^^^ The peptide mediated gene expression was not affected in PC 12 cells by co incubation with a blocking antibody against the low affinity NGF receptor p 75 and was significantly enhanced in NIH3T3 cells stably transfected with TrkA cDNA , suggesting the involvement of the high affinity NGF receptor TrkA without the participation of p 75 . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In the cell culture model of nerve growth factor ( NGF ) deprived sympathetic neurons , we find that CEP 11004 induced a approximately 3 fold increase in the mRNA and protein levels of TrkA , the NGF receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Treatment of PC 12 cells with buthionine sulfoximine ( BSO ) reduced the levels of GSH , a major cellular reductant , and enhanced NGF induced neuronal differentiation , activation of AP 1 and the NGF receptor tyrosine kinase , TrkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Because NGF signals through the tyrosine kinase ( TrkA ) NGF receptor and / or the p75NTR receptor , we used rescue experiments with a PC 12 cell mutant lacking TrkA to show that NGF induced PPARgamma activation is dependent on TrkA activation . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We demonstrate that NGF depolarizes the membrane of PC 12 cells within a minute and by using transfected NIH 3T3 Trk and p 75 cells we show that both the high affinity NGF receptor p 140 ( trk ) and the low affinity NGF receptor or p 75 ( NGF ) may be involved in the depolarization . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
When normal mybolasts were examined in vivo for expression of NGF receptors , p 75 ( NTR ) was detected on myoblasts but the high affinity NGF receptor , trk A , was not co expressed with p 75 ( NTR ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Furthermore , hyperoxic exposure increased the expression of TrkB in peribronchial smooth muscle but had no effect on the distribution of the specific NGF receptor TrkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In embryonic day ( E ) 15 rat trigeminal ganglion ( TG ) , NGF receptor TrkA is expressed by small diameter neurons , NT 3 receptor TrkC and BDNF receptor TrkB are expressed by large diameter neurons . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To test the hypothesis that trkA ( the high affinity NGF receptor ) is selectively expressed in nociceptive dorsal root ganglion ( DRG ) neurons , we examined the intensity of trkA immunoreactivity in single dye injected rat DRG neurons , the sensory receptor properties of which were identified in vivo with mechanical and thermal stimuli . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Thus , we tested the hypothesis that exposure to ethanol would affect NGF synthesis as well as expression of NGF receptor trkA in this cell population . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Expression levels of the NGF receptor TrkA , and NGF induced increases in mRNAs for the immediate early genes ( IEGs ) c fos and NGF inducible ( NGFI ) genes NGFI A , NGFI B and NGFI C , were identical among subclones . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Using intrathecal antisense against the NGF receptor , receptor tyrosine kinase ( TrkA ) , we found NGF to act at the primary afferent nociceptor directly in the Sprague Dawley rat . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We developed indirect ELISA methods for : choline acetyltransferase ( ChAT ) ; the vesicular acetylcholine transporter ( VAChT ) ; the high affinity choline transporter ( HACT / CHT ) ; TrkA , the high affinity NGF receptor ; the p 75 neurotrophin receptor ( p 75 ( NTR ) ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
These results suggest the signal transduction pathway from NGF receptor TrkA to transcription factor Sp 1 protein binding to the promoter Sp 1 like motif in NGF induced rat SPHK 1 gene expression . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Rat weight , estrous cyclicity , ovarian morphology , ovarian mRNA , and protein expression of alpha 1 AR subtypes , beta 2 AR , the NGF receptor tyrosine kinase A ( TrkA ) , p 75 neurotrophin receptor ( p75NTR ) , and tyrosine hydroxylase ( TH ) were analyzed . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In this study , we investigated alterations in the NGF pathway in keratoconus affected corneas and found a total absence of the NGF receptor TrkA ( TrkA ( NGFR ) ) expression and a decreased expression of NGF and p 75 ( NTR ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Meanwhile , nerve growth factor ( NGF ) is critically involved in cell survival and neuroprotective effects via the extracellular signal related kinase ( ERK ) pathway or the phosphatidylinositol 3 kinase ( PI 3 K ) pathway mediated by the high affinity NGF receptor , tropomyosin related kinase A ( TrkA ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In chick retina , migratory RGCs express p 75 ( NTR ) , whereas layered RGCs express the high affinity NGF receptor TrkA , which may switch the pro apoptotic signaling of p 75 ( NTR ) into a neurotrophic one . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The expression of NGF is high in injured and inflamed tissues , and activation of the NGF receptor tyrosine kinase trkA on nociceptive neurons triggers and potentiates pain signalling by multiple mechanisms . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Furthermore , since mutations to the NGF receptor , TrkA , have been noted to alter the behaviour of PC 12 cells in response to NGF , a PC 12 subline that expresses a mutated TrkA receptor was utilized to illustrate that a Y785F mutation in the cytoplasmic tail of TrkA results in increased migration in response to the stimulus compared to the control PC12s . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To further explore details of this mechanism , the expression of nerve growth factor ( NGF ) , production of which is induced by inflammatory cells and of the NGF receptor TrkA was examined in the PNS and the dorsal root ganglion using immunohistochemistry and a ribonuclease protection assay . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The compound induced sustained extracellular signal regulated kinase ( ERK ) activation that is crucial for neurite outgrowth activity without activating NGF receptor , TrkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Binding to isolectin B 4 ( IB 4 ) and expression of tyrosine kinase A ( trkA ) ( the high affinity NGF receptor ) have been used to define two different subgroups of nociceptive small dorsal root ganglion ( DRG ) neurons . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The p 75 ICD was not recruited into the TrkA containing high molecular weight complex , indicating that gamma secretase mediated removal of the p 75 TM domain may perturb the interaction with TrkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
These observations suggest that the trk protooncogene product , expressed in the absence of the fNGFR , binds NGF with properties characteristic of the sNGFR , which was identified as the high affinity NGFR on primary neurons and PC 12 cells . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Nerve growth factor ( NGF ) binds to a specific cell surface receptor ( NGFR ) that exists in high affinity ( now called trk ) and low affinity ( now called p75NGFR ) forms . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
These compounds were also found to inhibit the binding of [ 125I ] NGF to its receptors in membranes from PC 12 cells ( which express p 75 as well as trka receptors for NGF ) and DG 44 CHO cells ( transfected with full length p 75 NGFR ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Thirdly , two kinds of the neurotrophin family receptors were characterized , they are low affinity NGFR ( p 75 NGFR ) and the trk proto oncogene product such as p140trkA , p145trkB and p145trkC . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Regardless of the presence or absence of p 75 NGFR , neither DA group expresses trkA mRNA , indicating that these two major hypothalamic subsets of DNA neurons are NGF insensitive . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Colocalization experiments revealed that virtually all striatal trkA immunoreactive neurons ( > 99 % ) coexpressed choline acetyltransferase ( ChAT ) but not p 75 nerve growth factor receptor ( NGFR ) . ^^^ Within the septal / diagonal band complex virtually all trkA neurons ( > 95 % ) coexpressed both ChAT and p 75 NGFR . ^^^ More caudally , dual stained sections revealed numerous trkA / ChAT ( > 80 % ) and trkA / p75 NGFR ( > 95 % ) immunoreactive neurons within the nucleus basalis . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The enhancement of chemotactic response and heparanase production was detected at NGF concentrations sufficient to fully saturate both low and high affinity NGF receptors ( NGFR ) , the neurotrophin receptor ( p 75 ) and the trkA gene product , respectively . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Nineteen granular cell tumors ( GCT ) of adults , two congenital granular cell epulides and five epulides fibrosae were immunohistochemically examined to detect the expression of 75 kDa nerve growth factor receptor ( NGFR ) , trk gene product , phosphotyrosine ( PT ) , protein gene product 9 . 5 ( PGP9 . 5 ) and S 100 protein . ^^^ The NGFR immunoreactivity ( IR ) and trk gene product IR were expressed on almost all granular cells of GCT . ^^^ Congenital granular cell epulides and epulides fibrosae were negative for NGFR IR , trk gene product IR and PT IR . ^^^ NGFR and trk gene product expressed on GCT seems to be functional in terms of phosphorylation of the tyrosine residue in the receptor or downstream protein in signal transduction . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
This response was apparent by 24 h , did not occur with NGF treatment or when vector or TrkA NGFR were expressed and was reversed by dexamethasone pretreatment . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NGFR ) and TrkA receptors collaborate to rapidly activate a p 75 ( NGFR ) associated protein kinase . ^^^ In PC 12 cells , TrkA activation was necessary to elicit p 75 ( NGFR ) associated kinase activity . ^^^ These findings show that p 75 ( NGFR ) accelerates TrkA mediated signaling and , in addition , demonstrate that p75NGFR and TrkA collaborate to activate a previously undescribed p 75 ( NGFR ) associated protein kinase . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The R 3 peptide had no effects on cell survival , cell binding or uptake of [ 125 ] NGF , affinity cross linking of [ 125 ] NGF to p 75 ( NGFR ) or trkA monomers and homodimers , of NGF mediated trkA monomer tyrosine phosphorylation . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Both p 140 ( trk ) and p 75 ( NGFR ) nerve growth factor receptors mediate nerve growth factor stimulated calcium uptake . ^^^ Human p 140 ( trk ) and p 75 ( NGFR ) were transfected separately into 3T3 cells . ^^^ Nerve growth factor stimulates calcium uptake into both transfectants but not into untransfected 3T3 cells . p 140 ( trk ) cells were stimulated maximally by 25 ng / ml ; 100 ng / ml was submaximal for p 75 ( NGFR ) cells . ^^^ K 252a inhibits the effect of NGF on p 140 ( trk ) cells but not on p 75 ( NGFR ) cells ; brain derived neurotrophic factor stimulates calcium uptake in p 75 ( NGFR ) cells but not in p 140 ( trk ) cells . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The neurotrophins and their corresponding Trk and p 75 ( NGFR ) receptor subtypes are families of growth factors and receptors that have received relatively little attention with respect to neoplasia . ^^^ In this regard , we have focused on our studies of neurotrophin Trk / p75 ( NGFR ) expression and interactions in pancreatic ductal carcinoma ( PDAC ) and their potential role in the perineural invasive phenotype characteristic of this cancer . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Apparently , p 75 ( NGFR ) mediates apoptosis of these developing neurons in the absence of TrkA , and modulation of p 75 ( NGFR ) can promote neuronal survival . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Cholinergic medial septum neurons express TrkA and p 75 nerve growth factor receptor ( p 75 ( NGFR ) ) and interactions between TrkA and p 75 ( NGFR ) are necessary for high affinity binding and signaling of nerve growth factor ( NGF ) through TrkA . ^^^ Here , we investigated whether chronic and long term absence of p 75 ( NGFR ) ( and possibly reduced NGF transport and TrkA binding ) would affect the cholinergic septohippocampal system during aging in mice . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Several lines of evidence implicate nerve growth factor ( NGF ) signaling through its receptors ( TrkA and p 75 ( NGFR ) ) as a potential source of communication between the two systems . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The effect of NGF appeared to be mediated by its trkA receptors ( trkA ( NGFR ) ) , as suggested by the potent inhibition of both MCF 7 cell proliferation and trkA ( NGFR ) phosphorylation occurring upon treatment of cultures with the selective trkA ( NGFR ) inhibitor K252a . ^^^ Surprisingly , the antiestrogen drug tamoxifen ( TAM ) inhibited NGF induced MCF 7 cell proliferation and trkA ( NGFR ) phosphorylation in a concentration related fashion . ^^^ The effect of TAM seemed to be estrogen receptor independent , because the pure estrogen receptor antagonist ICI 182 . 780 was unable to block NGF induced trkA ( NGFR ) phosphorylation . ^^^ Our data underline the new emerging role of trkA ( NGFR ) in breast tumor growth , and suggest a related novel therapeutic use of TAM in breast cancer . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
A slight transient increase in the expression of p 75 ( NGFR ) mRNA was observed by 2 to 4 h after retinoid treatment of undifferentiated cells , whereas a larger increase in the expression of both TrkA and p 75 ( NGFR ) mRNA up to threefold the basal level , was observed by 2 to 6 h after retinoid treatment of NGF differentiated cells . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Here we show that inactivation of p 75 ( NGFR ) , but not of trkA , resulted in D ( 2 ) receptor loss in responder cells and prevented D ( 2 ) receptor expression induced by NGF in the nonresponder . ^^^ These data indicate that in prolactinoma cells the effect of NGF on D ( 2 ) receptor expression is mediated by p 75 ( NGFR ) in a trkA independent way and that NGF stimulation of p 75 ( NGFR ) activates NF kappaB , which is required for D ( 2 ) gene expression . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
RT PCR analysis and immunological methods demonstrate that human umbilical vein endothelial cells ( HUVECs ) express the NGF receptors trkA ( NGFR ) and p75NTR . ^^^ NGF treatment caused a rapid phosphorylation of trkA ( NGFR ) in HUVECs , determining a parallel increase of phosphorylated ERK1 / 2 . ^^^ Accordingly , NGF induced a significant increase in HUVEC proliferation that was abolished by the trkA ( NGFR ) inhibitor K252a . ^^^ Endogenous NGF was responsible for the basal levels of trkA ( NGFR ) and ERK1 / 2 phosphorylation observed in untreated HUVEC cultures . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Previously , we have shown using the double immunostaining method that the NGF receptors ( NGFR ) p 75 and TrkA are expressed mainly on subpopulations of GFAP+ astrocytes , and this expression increases progressively after ischemia . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Higher levels of expression of Trk receptors in cutaneous squamous cell carcinoma cells may predict perineural invasion and the increased p 75 ( NGFR ) expression found in cutaneous squamous cell carcinoma perineurally may allow p 75 ( NGFR ) immunohistochemical staining to be used for detecting sites of perineural invasion . . ^^^ BACKGROUND : Neural cell adhesion molecule ; nerve growth factor ; and its receptors TrkA , TrkB , TrkC , and p 75 ( NGFR ) regulate unique survival pathways in the cells of different noncutaneous malignancies exhibiting a perineural invasive phenotype . ^^^ OBJECTIVE : The objective was to evaluate neural cell adhesion molecule , nerve growth factor , TrkA , TrkB , TrkC , and p 75 ( NGFR ) expression when perineural invasion occurs in basal cell carcinoma and cutaneous squamous cell carcinoma . ^^^ METHODS : Four basal cell carcinomas and five cutaneous squamous cell carcinomas that were perineural invasion positive and four basal cell carcinomas and three cutaneous squamous cell carcinomas that were perineural invasion negative were evaluated for the expression of neural cell adhesion molecule , nerve growth factor , TrkA , TrkB , TrkC , and p 75 ( NGFR ) by immunohistochemical staining . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Brain derived neurotrophic factor ( BDNF ) belongs to the neurotrophin family which interacts with high affinity protein kinase receptors ( Trk ) and the unselective p 75 ( NGFR ) receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
OBJECTIVE AND METHODS : To examine the involvement of neurotrophic factor receptors in the testis with acute experimental testicular torsion , the expression of tyrosine kinase receptors ( trk ) A and B , and p 75 nerve growth factor receptor ( NGFR ) were studied in the rat testis with ischemia / reperfusion ( I / R ) injury , using Western blotting and immunohistochemistry . ^^^ CONCLUSION : It is postulated that trk A and B , but not p 75 NGFR , are involved differently in the survival of testicular cells during acute experimental testicular torsion . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
METHODS : Expression of NGF , trkA ( NGFR ) and p75NTR on human fibroblasts grown from conjunctival biopsies and incubated for 2 or 6 days with NGF were evaluated by immunofluorescence , RT PCR , flow cytometry and ELISA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
BACKGROUND AND AIM : The aim of the present study was to investigate the prognostic value of the two types of nerve growth factor receptors ( NGFR ) , namely high affinity receptor TrkA and low affinity receptor p75NGFR , in pancreatic cancer . ^^^ METHODS : The mRNA expression of NGFR for TrkA and p75NGFR was examined in 56 human primary pancreatic cancers using real time quantitative reverse transcription polymerase chain reaction . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Interestingly in the cornea , where NGF , trkA ( NGFR ) and p 75 ( NTR ) are expressed by epithelial cells and keratocytes , the NGF eye drop induces the healing of neurotrophic or autoimmune corneal ulcers . ^^^ NGF , trkA ( NGFR ) and p 75 ( NTR ) were found expressed by fibroblastic keratocytes . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Modulation by co expression of p75NTR with Trk receptors . ^^^ We examined neurotrophin induced sphingomyelin hydrolysis in cells expressing solely the low affinity neurotrophin receptor , p75NTR , and in PC 12 cells that co express p75NTR and Trk receptors . ^^^ NT 3 did not induce sphingomyelin hydrolysis in Trk C NIH 3T3 cells nor in cells expressing a mutated p75NTR containing a 57 amino acid cytoplasmic deletion , thus demonstrating the role of p75NTR in this signal transduction pathway . ^^^ However , in the presence of NGF , NT 3 was unable to induce sphingomyelin hydrolysis , raising the possibility that Trk was modulating p75NTR dependent sphingomyelin hydrolysis . ^^^ These data support that p75NTR serves as a common signaling receptor for neurotrophins through induction of sphingomyelin hydrolysis and that crosstalk pathways exist between Trk and p75NTR dependent signaling pathways . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
These data demonstrate that p75NTR is capable of signaling independently of the trk neurotrophin receptor ( p140trk ) and that ceramide may be a mediator in neurotrophin biology . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In the absence of p140proto trkA , the matrix dependent effects of NGF on metalloproteinase expression of brain metastatic 70W melanoma cells suggest a signaling role for the low affinity melanoma p75NTR receptor and its associated purine analogue sensitive kinase in signaling enhanced matrix penetration of NGF rich stromal microenvironments such as the brain . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) , and neurotrophin 3 ( NT 3 ) selectively bind to distinct members of the Trk family of tyrosine kinase receptors , but all three bind with similar affinities to the neurotrophin receptor p 75 ( p75NTR ) . ^^^ The biological significance of neurotrophin binding to p75NTR in cells that also express Trk receptors has been difficult to ascertain . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The prenatal development of the neurons immunoreactive for high affinity tropomycin related kinase ( trk ) receptor ( pan trk which recognizes trkA , trkB , and trkC ) and low affinity p 75 neurotrophin receptor ( p75NTR ) was examined in the human brain from embryonic weeks 10 to 34 of gestation . ^^^ The staining pattern for both trk and p75NTR remained unchanged at embryonic weeks 15 to 16 except for the addition of trk ir and p75NTR ir within the cortical subplate zone , hippocampus , and subthalamic nucleus . ^^^ This staining pattern for trk and p75NTR remained virtually unchanged from embryonic weeks 19 to 20 and embryonic weeks 16 to 20 , respectively . ^^^ From embryonic weeks 22 to 34 , the distribution of both trk ir and p75NTR ir neurons changed gradually . ^^^ During this period , neurons in most thalamic and some brainstem nuclei became progressively immunonegative for trk , whereas neurons in the neocortical subplate zone , corpus callosum , and hilar region of dentate gyrus gradually lost immunoreactivity for p75NTR . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Axonal accumulation of p75NTR and TrkA in the septum following lesion of septo hippocampal pathways . ^^^ Since NGF exerts its effects via p75NTR and TrkA receptors coexpressed in vast majority of these neurones and down regulated without NGF treatment after injury , in this study we aimed to examine how does the lesion to the cholinergic tracts affect distribution of both types of receptor proteins in damaged fibres . ^^^ We found accumulation of p75NTR and TrkA immunoreactive material ( so called `` pile up ' ' ) within axonal segments of distended appearance proximal to the transection at two days postlesion and its translocation towards cell bodies seven days postsurgery . ^^^ We observed p75NTR pile up to be more intense than TrkA , which may indicate different cellular concentrations of both receptors . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
K 252b potentiation of neurotrophin 3 is trkA specific in cells lacking p75NTR . ^^^ This is the first demonstration that K 252b potentiates a trkA mediated biological nonneuronal response by NT 3 that occurs independent of p75NTR and appears to be both ligand and receptor specific . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Likewise , p75NTR , when activated in the absence of a strong Trk signal , induces apoptosis of neurons , while in the presence of Trk it enhances responses to neurotrophin . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
For nerve growth factor ( NGF ) , these are p75NTR ( p 75 ) and p140trk ( referred to as trk or trkA ) , which binds both BDNF and neurotrophin ( NT ) 4 / 5 , and trkC receptor , which binds only NT 3 . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To investigate the effect of p75NTR expression in neuroblastoma cells , we transfected the p75NTR cDNA into SK N BE cells , a neuroblastoma cell line that lacks expression of both p75NTR and TrkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The possibility that these neurotrophins may act in parallel and / or in sequence to regulate survival of developing granule neurons through different mechanisms is discussed in the light of findings on neurotrophin and p75NTR patterns , and p75NTR / high affinity Trk receptor coexpression . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The ongoing dissection of the roles of p75NTR and TrkA , B and C in neurotrophin signaling has generated a number of apparent paradoxes . ^^^ Limiting consideration to the role of p75NTR in cell death , a theory is proposed that is based on the following postulates : ( 1 ) that p75NTR displays a pro apoptotic intrinsic ( ligand independent , Trk independent ) receptor effect ( IRE ) , which is inhibited by ligand binding ; ( 2 ) that p75NTR and TrkA exhibit mutual repression of signaling ; and ( 3 ) that p75NTR and TrkA are required for the efficient generation of high affinity NGF binding sites . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In situ hybridization for p75NTR mRNA and trkA mRNA 6 months after bilateral fimbria fornix transection revealed a substantial loss of labelled cells . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Molecular modeling studies predict that Zn2+ binding to NGF will induce structural changes within domains of this neurotrophin that participate in the recognition of TrkA and p75NTR . ^^^ We demonstrate here that Zn2+ alters the conformation of NGF , rendering it unable to bind to p75NTR or TrkA receptors or to activate signal transduction pathways and biological outcomes normally induced by this protein . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To determine whether the p 75 neurotrophin receptor ( p75NTR ) plays a role in naturally occurring neuronal death , we examined neonatal sympathetic neurons that express both the TrkA tyrosine kinase receptor and p75NTR . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Reports of Trk receptor transcripts in non neural tissues raise the possibility that the sites of p75NTR expression during development may correlate with Trk receptor expression . ^^^ Coexpression of p75NTR with the Trk receptors in developing non neural tissues would support the hypothesis that there is a cooperative function between the two receptor subclasses . ^^^ To address these questions , p75NTR was localized relative to the three known Trk receptors in adjacent sections of rat embryos at stages of development when the highest levels of p75NTR have been observed in the muscle , maxillary pad , kidney , and lung . ^^^ Using in situ hybridization and immunhistochemical analyses , we show here that the Trk receptors are expressed extensively in non neural tissues during cell differentiation and tissue morphogenesis but in patterns that are generally reciprocal to that of p75NTR . ^^^ The results indicate p75NTR most likely functions independently of the Trk receptors in most developing non neural tissues . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The studies suggest that ligand mediated trkA activation has differential effects on cell motility phenomena and that the amphiphilic domain of p75NTR has a role in this differential signaling . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Nerve growth factor ( NGF ) , neurotrophin 3 , neurotrophin 4 , and brain derived neurotrophin exert their survival effect by binding to two transmembrane receptor types : trk receptors , which exhibit binding specificity , and the p75NTR receptor , which binds all neurotrophins . ^^^ Interestingly , levels of trkA protein were not increased on a per cell level , whereas levels of p75NTR increased nearly threefold . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Adjacent sections through the MS and NBM were processed for either immunocytochemical detection of choline acetyltransferase ( ChAT ) and p75NTR like immunoreactivity or for in situ hybridization detection and quantification of ChAT and trkA mRNA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The pheochromocytoma PC 12 cell line was used as a model system to characterize the role of the p 75 neurotrophin receptor ( p75NTR ) and tyrosine kinase ( Trk ) A nerve growth factor ( NGF ) receptors on amyloid precursor protein ( APP ) expression and processing . ^^^ These findings demonstrate that in PC 12 cells expressing p75NTR and TrkA receptors , binding of NGF to the p75NTR is required to mediate NGF effects on cell morphology and APP metabolism . ^^^ Lastly , we have shown that specific activation of TrkA receptors in contrast to p75NTR associated signaling stimulates neurite outgrowth and increases nonamyloidogenic secretory APP processing without increases in APP mRNA levels . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
These results show that neurotrophin action on neurotransmitter release was mostly mediated by Trk receptors with p75NTR having a little but significant positive role . ^^^ The role of TrkA and p75NTR receptors was investigated in NGF induced potentiation of glutamate release . ^^^ Antigen blot analysis showed the presence of TrkA , TrkB and p75NTR receptors in the visual cortex . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Reciprocal modulation of TrkA and p75NTR affinity states is mediated by direct receptor interactions . ^^^ Equilibrium binding of 125I nerve growth factor ( 125I NGF ) to cells coexpressing the tyrosine kinase receptor A ( TrkA ) and common neurotrophin receptor ( p75NTR ) , cells coexpressing both receptors where p75NTR is occupied , and cells expressing only p75NTR , revealed reciprocal modulation of receptor affinity states . ^^^ Analysis of receptor affinity states in PC 12 cells , PC 12 cells in the presence of brain derived neurotrophic factor ( BDNF ) , and PC12nnr5 cells suggested that liganded and unliganded p75NTR induce a higher affinity state within TrkA , while TrkA induces a lower affinity state within p75NTR . ^^^ These data are consistent with receptor allosterism , and prompted a search for TrkA / p75NTR complexes in the absence of NGF . ^^^ The heteroreceptor complex of TrkA and p75NTR alters conformation and / or dissociates in the presence of NGF , as indicated by the ability of low concentrations of NGF to prevent heteroreceptor crosslinking . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Previous work shows that gene expression for p75NTR in lumbar dorsal root ganglia ( DRG ) is deficient in streptozocin induced diabetic rats , while expression of trkA protein is unaffected . ^^^ We also investigated the novel effect of nerve growth factor ( NGF ) treatment on the levels of mRNA and protein of the NGF receptors , trkA and p75NTR , in normal and diabetic rats . ^^^ Anterograde and retrograde axonal transport of p75NTR within the sciatic nerve was similarly decreased in diabetic rats , while levels of transport of trkA were unaffected . ^^^ Treatment with systemic NGF reversed the diabetes induced deficit in p75NTR transcripts and protein within the DRG and left expression levels of trkA unchanged . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Radiolabeled NGF was transported in a receptor mediated fashion from the teeth to a subset of neurons in the trigeminal ganglion within 15 h , indicating that these neurons possess NGF receptors ( trk A and / or p75NTR ) . ^^^ Within the maxillary division of the trigeminal ganglion , trk A expression was elevated at 4 h post injury , with a maximum increase ( 2 fold ) after 52 h . p75NTR was increased by 28 h post injury and was increased 1 . 35 fold by 52 h . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
DEX elicited an increase in NGF mRNA and protein levels in the cerebral cortex and hippocampus as well as specific NGF responses , such as TrkA tyrosine phosphorylation in the septum , choline acetyltransferase ( ChAT ) and p 75 neurotrophin receptor ( p75NTR ) immunoreactivity , and a relative number of cholinergic neurons in the medial septum . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To stimulate TrkA and / or p75NTR signaling in PC 12 cells , we used NGF , brain derived neurotrophic factor ( BDNF ) , and NGF in the presence of an excess of BDNF or the monoclonal antibody 192IgG , to block p75NTR binding to NGF . ^^^ These findings suggest that in cells expressing p75NTR and TrkA receptors , binding of NGF to the p75NTR is required to mediate NGF effects on APP secretion . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
However , trk may act with p75NTR , as disruption of trk signalling alleviates the inhibitory response induced by NT 3 and RA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The trk receptors are responsible for the stereotypical survival and growth properties of the neurotrophins but defining the physiological function of the p75NTR has proven difficult . ^^^ The p75NTR binds each of the neurotrophins with low nanomolar affinity whereas the three trk receptors show strong binding preferences for individual neurotrophins ; in some cell types , p75NTR is the only neurotrophin receptor whereas in others it is co expressed with the trks . ^^^ Available data suggests that in cells where p75NTR is co expressed with trk receptors , p75NTR functionally collaborates with the trks to either enhance responses to preferred trk ligands , to reduce neurotrophin mediated trk receptor activation resulting from non preferred ligands or to facilitate apoptosis resulting from neurotrophin withdrawal . ^^^ In cells lacking trk expression , p75NTR can act autonomously to activate ligand dependent signaling cascades that may in some circumstances result in apoptosis but probably not through pathways utilized by its apoptotic brethren in the TNF receptor superfamily . ^^^ The p 75 neurotrophin receptor ( p75NTR ) and trkA , trkB and trkC mediate the physiological effects of the neurotrophins . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Neurotrophins exert their biological functions on neuronal cells through two types of receptors , the trk tyrosine kinases and the low affinity neurotrophin receptor ( p75NTR ) , which can bind all neurotrophins with similar affinity . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The effects of this delivery over 12 days were then determined on expression of growth associated protein 43 , trkA , p75NTR and preprotachykinin A ipsilateral and contralateral to the pump in dorsal root ganglia at L 4 and L 5 ( pooled ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In this report , we provide evidence that NGF and BDNF have functionally antagonistic actions on sympathetic neuron growth and target innervation , with NGF acting via TrkA to promote growth and BDNF via p75NTR to inhibit growth . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We show that NT 2 N cells express rRNAs for TrkA , TrkB , and TrkC tyrosine kinase receptors and the low affinity nerve growth factor receptor ( p75NTR ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
A similar dissociation of p75NTR and trk regulation has previously been reported in other neuronal systems during aging , suggesting that there may be a common underlying mechanism . ^^^ We have here examined the expression of neurotrophin receptor ( p75NTR , trkA , trkB , and trkC ) mRNA and protein in intact and axotomized primary sensory neurons of young adult ( 3 months ) and aged ( 30 months ) rats . ^^^ After axotomy , a down regulation of mRNA and protein levels was observed for all neurotrophin receptors ( p75NTR , trkA , trkB and trkC ) in both young adult and aged rats . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Nerve growth factor ( NGF ) , the prototypic member of the neurotrophin family of growth factors , exerts its action via two receptors , P75NTR and TrkA , the expression of which varies at the cell surface of neuroblastoma cells ( SH SY5Y cells ) in a cycle phase specific manner . ^^^ NGF was pro apoptotic on growing cells expressing preferentially P75NTR and exhibited a potent anti apoptotic effect on quiescent cells , when TrkA was prevalent at the cell surface , showing that NGF can have a dual action on SH SY5Y cells depending on the relative cell surface expression of TrkA and P75NTR . ^^^ On the other hand , we showed that the anti apoptotic activity of NGF was specifically mediated by an interaction with TrkA with no contribution of P75NTR , as demonstrated on SK N BE cells transfected with TrkA in which NGF was a potent anti apoptotic compound but did not exhibit any pro apoptotic activity . ^^^ These results support the hypothesis that the survival response to NGF depends on its binding to TrkA without any involvement of P75NTR which in turn selectively mediates the pro apoptotic activity of NGF with no contribution of TrkA and show that , depending on the growth state of the cells , NGF exhibits dual pro or anti apoptotic properties via P75NTR and TrkA , respectively . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The p 75 neurotrophin receptor ( p75NTR ) binds all known neurotrophins and has been suggested to either function as a coreceptor for the trk receptor tyrosine kinases or be involved in independent signaling leading to cell death . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Additionally , we characterized the molecular expression of NT high affinity ( Trk ) and low affinity ( p75NTR ) receptors in these cell lines by reverse transcription polymerase chain reaction . ^^^ The role of the neurotrophins ( NTs ) and their corresponding receptors ( NTRs ) TrkA , TrkB , TrkC , and p75NTR in neoplasia has received relatively little attention . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Neurotrophins are a family of proteins with pleiotropic effects mediated by two distinct receptor types , namely the Trk family , and the common neurotrophin receptor p75NTR . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The neurotrophin receptor ( p75NTR ) is best known for mediating tropic support by participating in the formation of high affinity nerve growth factor ( NGF ) receptor complexes with trkA , however , p75NTR more recently has been shown to act as a bona fide death signaling receptor , which can signal independently of trkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In order to dissect the potential role of p75NTR , the common neurotrophin receptor , in neurotrophin dependence , we expressed wild type and mutant p75NTR in cells that do not express endogenous p75NTR or Trk family members ( NIH3T3 ) . ^^^ Expression of wild type p75NTR created a state of neurotrophin dependence : cells could be rescued by nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) , or neurotrophin 3 ( NT 3 ) , but not by a mutant NGF that binds well to Trk A but poorly to p75NTR . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
While MC CM raised mRNA for trkA , the effect was not synergistic with NGF . mRNA for the common neurotrophin receptor ( p75NTR ) showed a modest synergistic increase . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Proteins for both the high affinity NGF specific tyrosine kinase binding site ( p140TrkA ; TrkA ) and the low affinity neurotrophin ( p75NTR ) receptor were present in all three GBM cell lines . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Dexamethasone induces TrkA and p75NTR immunoreactivity in the cerebral cortex and hippocampus . ^^^ Nerve growth factor ( NGF ) plays a crucial role in synaptic plasticity during brain development and adulthood by activating a dual receptor system composed of TrkA and p 75 ( p75NTR ) receptors . ^^^ The ability of glucocorticoids to increase NGF expression in the hippocampus prompted us to investigate whether the synthetic glucocorticoid dexamethasone ( DEX ) increases TrkA and p75NTR expression in NGF target cholinergic neurons in developing rats . ^^^ Immunohistochemical analysis of p75NTR and TrkA levels revealed a dramatic increase in p75NTR immunoreactivity ( IR ) in both basal forebrain and hippocampus and TrkA IR in the hippocampus . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The chapter discusses the presence of neurotrophin receptors on glial cells , glial cells as producers of neurotrophins , signaling pathways downstream Trk and p75NTR , and the significance of neurotrophins and their receptors for glial cells during development , in cell death and survival , and in neurological disorders . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Neurotrophins use two types of receptors , the Trk tyrosine kinase receptors and the p 75 neurotrophin receptor ( p75NTR ) , to regulate the growth , development , survival and repair of the nervous system . ^^^ The development and survival of neurons is thus based upon the functional interplay of the signals generated by Trk and p75NTR . ^^^ In the past two years , the signaling pathways used by these receptors , including Akt and MAPK induced signaling via Trk , and JNK , p 53 , and NF kappaB signaling via p75NTR , have been identified . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Using double labeling immunocytochemistry , the rat monoclonal antibody CHO 5 against mouse p75NTR was found to label mouse basal forebrain neurons , which also demonstrated immunoreactivity for choline acetyltransferase and the high affinity nerve growth factor receptor , TrkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The mRNAs for NGF , BDNF with exon 4 , NT 3 , p75NTR , and all Trk members were detected in the LN untreated liver . ^^^ LN treatment resulted in increases in the levels of NGF , BDNF with exon 4 , NT 3 , p75NTR , and TrkA mRNAs and further led to expression of BDNF mRNA with exon 3 . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In the present study , the changes in expression of the neurotrophins ( NGF , BDNF , and NT 3 ) and their cognate receptors ( i . e . , trk and p75NTR ) during the progression of normal prostatic epithelial cells to malignancy were documented . ^^^ These stromal cells lack both trk and p75NTR receptors . ^^^ In contrast , malignant prostate epithelial cells directly secrete a series of neurotrophins ( i . e . , NGF , BDNF , and / or NT 3 ) and express at least one if not more of the trk receptor proteins ( i . e . , trk A , B , and / or C ) , while no longer expressing the p75NTR receptors . ^^^ This is coupled to the ectopic expression of trk B and trk C , as well as to the continued expression of trk A , and the loss of expression of p75NTR receptors . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
METHODS : Immunocytochemistry and Western blot analyses were performed using primary antibodies raised against NTs ( nerve growth factor [ NGF ] , brain derived neurotrophic factor [ BDNF ] , NT 3 , and NT 4 / 5 ) and NT receptors ( TrkA , TrkB , TrkC , and p75NTR ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
TrkA expressing trigeminal sensory neurons display both neurochemical and structural plasticity despite a loss of p75NTR function : responses to normal and elevated levels of nerve growth factor . ^^^ Depleting p75NTR expression reduces both the survival of trkA positive sensory neurons and their afferent innervation of peripheral targets . ^^^ Although p75NTR deficient mice have 30 % fewer trigeminal neurons , levels of trkA mRNA expression are modestly elevated in these mutant mice as compared to control mice . ^^^ Thus , despite the survival of fewer trigeminal neurons , neither ganglionic levels of trkA mRNA expression nor the density of central afferent projections are depleted in p75NTR deficient mice . ^^^ In response to elevated levels of NGF protein , transgenic mice with and without p75NTR expression display both increased levels of trkA mRNA expression and a greater density of trigeminal central afferent axons as compared to control mice . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Furthermore , antisense p75NTR oligonucleotides rescued trkA , B , and C expressing neurons , while NGF and leukemia inhibitory factor targeted primarily the trkA positive neurons . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
PC 12 and INS 1 cells both express the nerve growth factor ( NGF ) receptors trkA and p75NTR and the epidermal growth factor receptor ( EGF ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
SCI induces the expression of the low affinity neurotrophin receptor p 75 ( p75NTR ) , that in the absence of the high affinity component , TrkA , can promote cell death by apoptosis . ^^^ DEX , given at high doses ( 20 mg / kg , s . c . ) but not at low doses ( 1 or 8 mg / kg ) prevented the increase in p75NTR mRNA and protein in SCI rats , without affecting the expression of TrkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Nerve growth factor is capable of stimulating a proliferative response via a high affinity Trk receptor present in normal and malignant prostate epithelia , and alternatively can mediate apoptosis via the low affinity p75NTR receptor that is progressively lost from the malignant prostate . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We show that p75NTR dependent Akt phosphorylation was independent of TrkA signaling , required active phosphatidylinositol 3 kinase , and was associated with increased tyrosine phosphorylation of p 85 and Shc and with reduced cytosolic tyrosine phosphatase activity . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Neurotrophins activate two different classes of receptors , the Trk family of receptor tyrosine kinases and p75NTR , a member of the TNF receptor superfamily . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The finding that two proteins , p75NTR and Trk , act as receptors for NGF in neurons generated the discovery of other neurotrophic factors / receptor families and has enhanced our understanding of the development , survival , regeneration , and degeneration of the nervous system . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In this review , we focus on the proapoptotic actions of the p 75 neurotrophin receptor ( p75NTR ) , and on the interplay between Trk and p75NTR that determines neuronal survival . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Sections of pancreatic cancer and normal pancreatic tissue were examined by immunohistochemistry for the expression of the neurotrophins NGF , BDNF , NT 3 , NT 4 , and their receptors TrkA , TrkB , and TrkC , as well as the low affinity receptor , p75NTR . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The biological action of neurotrophins is thus regulated by proteolytic cleavage , with proforms preferentially activating p75NTR to mediate apoptosis and mature forms activating Trk receptors to promote survival . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Specifically , experiments presented here demonstrate that the presence or absence of p75NTR does not alter Trk activity or NGF and NT 3 mediated downstream survival signaling in primary neurons . ^^^ TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR mediated death signal . ^^^ Developmental sympathetic neuron death is determined by functional interactions between the TrkA / NGF receptor and the p 75 neurotrophin receptor ( p75NTR ) . ^^^ A key question is whether p75NTR promotes apoptosis by directly inhibiting or modulating TrkA activity , or by stimulating cell death independently of TrkA . ^^^ Crosses of p75NTR / and TrkA / mice indicate that the coincident absence of p75NTR substantially rescues TrkA / sympathetic neurons from developmental death in vivo . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Expression of the nerve growth factor receptors TrkA and p75NTR in the visual cortex of the rat : development and regulation by the cholinergic input . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Neurotrophin signaling is mediated by Trk family tyrosine kinases such as TrkA , TrkB and TrkC , as well as by the pan neurotrophin receptor p75NTR . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Dystrophic axons were immunoreactive for neuropeptide Y , tyrosine hydroxylase , dopamine beta hydroxylase , trkA and p75NTR , an immunophenotype consistent with their origin from postganglionic sympathetic neurons , and contained large numbers of highly phosphorylated neurofilaments or tubulovesicular elements . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
METHODS : Expression of NGF , TrkA , and p75NTR was investigated in HCCs developing and regenerating livers , and primary hepatocyte cultures in B6C3F ( 1 ) mice by reverse transcription polymerase chain reaction , Northern blotting , and / or immunohistochemistry . ^^^ Although neither TrkA nor p75NTR was detectable in either HCC or normal hepatic cells , TrkA was shown in the walls of tumor associated arteries that contain abundant nerve fibers . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Their actions on neural tissue are thought to be mediated by interaction with high affinity ( trk family members ) or low affinity ( p75NTR ) cell surface receptors . ^^^ We have used immunofluorescence techniques with a panel of antibodies against known neurotrophin receptors ( trk A , trk B , trk C , p75NTR ) to map the locations of these receptors in the developing neuromuscular system of mice from our neurotrophin 3 ( NT 3 ) knockout colony . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The signal transducing systems that mediate the diverse biological functions of the neurotrophins are initiated by their interactions with two categories of cell surface receptors , the Trk family of tyrosine kinases and the p 75 neurotrophin receptor ( p75NTR ) . ^^^ While the Trk receptors are responsible for most of the survival and growth properties of the neurotrophins , the actions of p75NTR fall into two categories . ^^^ First , p75NTR is a Trk co receptor that can enhance or suppress neurotrophin mediated Trk receptor activity . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Ten cases of ON and five cases of nasopharyngeal carcinoma were examined for expression of trkA and p 75 neurotrophin receptor ( p75NTR ) using immunohistochemistry and double labelling fluorescence . ^^^ We found that all ON tissues from 10 cases expressed both trkA and p75NTR at different levels . ^^^ Double staining revealed that almost all trkA immunoreactive ON cells also contained p75NTR immunoreactivity . ^^^ By contrast , no trkA or p75NTR immunoreactivity was detected in nasopharyngeal carcinoma cells from five patients . ^^^ These results suggest that nerve growth factor may play a role in the generation of ON and staining of trkA and p75NTR may assist in the diagnosis of ON . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The contrary response of different cells to neurotrophins in terms of cell cycle regulation derives in part from the fact that these factors use two different receptor types to transmit their signals : members of the Trk family and the p 75 neurotrophin receptor ( p75NTR ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
On the one hand , p75NTR provides a positive modulatory influence on nerve growth factor ( NGF ) signaling through the high affinity neurotrophin receptor TrkA , and hence increases NGF survival signaling . ^^^ However , p75NTR may also signal independently of TrkA , causing cell death or cell survival , depending on the cell type and stage of development . ^^^ In mouse hippocampal cells lacking p75NTR ( p75NTR / ) activation of TrkA by NGF was not detectable . ^^^ P75NTR signaling independent of TrkA , such as increased neutral sphingomyelinase ( NSMase ) activity causing enhanced levels of ceramide , were not detected after exposure of hippocampal neurons to NGF . ^^^ Overall , our results indicate an essential role for p75NTR in supporting NGF triggered TrkA signaling pathways mediating neuronal survival in hippocampal neurons . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Perhaps the most fascinating aspect of Trk receptor mediated signaling is its interplay with signaling promoted by the pan neurotrophin receptor p75NTR . p75NTR activates a distinct set of signaling pathways within cells that are in some instances synergistic and in other instances antagonistic to those activated by Trk receptors . ^^^ Several of these are proapoptotic but are suppressed by Trk receptor initiated signaling . p75NTR also influences the conformations of Trk receptors ; this modifies ligand binding specificity and affinity with important developmental consequences . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Individual and combined effects of TrkA and p75NTR nerve growth factor receptors . ^^^ A long standing question in neurotrophin signal transduction is whether heteromeric TrkA p75NTR complexes possess signaling capabilities that are significantly different from homo oligomeric TrkA or p75NTR alone . ^^^ To address this issue , various combinations of transfected PC 12 cells expressing a platelet derived growth factor receptor TrkA chimera and the p75NTR selective nerve growth factor mutant ( Delta9 / 13 NGF ) were utilized to selectively stimulate TrkA or p75NTR signaling , respectively . ^^^ Whereas activation of TrkA signaling is sufficient for eliciting neurite outgrowth in PC 12 cells , signaling through p75NTR plays a modulatory role , especially in the increased formation of fine , synaptic `` bouton like ' ' structures , in which both TrkA and p75NTR appear to co localize . ^^^ In addition , a new interaction in the TrkA / p75NTR heteromeric receptor signal transduction network was revealed , namely that NGF induced activation of the MAPK pathway appears to inhibit the parallel NGF induced Akt pathway . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The neurotrophins are able to bind to two different receptors : all bind to a common receptor p75NTR , and each also binds to one of a family of Trk receptors . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Although neurotrophins did not regulate p75NTR processing , the alpha and gamma secretase mediated cleavage of p 75 is modulated by receptor tyrosine kinases ( Trks ) TrkA and TrkB but not TrkC . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
However , NGF rescue from growth factor withdrawal requires NGF signalling through the high affinity tyrosine kinase receptor ( TrkA ) , while NGF rescue from TNFalpha promoted cell death requires NGF signalling through the low affinity p75NTR receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To elucidate the underlying mechanisms expression of the neurotrophin receptors p75NTR , trkA , trkB , and trkC on eosinophils was analyzed by RT PCR and immunocytology . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Recent evidence indicates that some thymic cells of developing and adult laboratory animals express the neurotrophin NGF and its low affinity p75NTR and high affinity TrkA receptor . ^^^ The immunoreactivity of NGF , p75NTR , TrkA and cytokeratin was found in the epithelial thymocyte microenvironment . ^^^ They suggest a possible immunotrophic / immunoregulatory role of the NGF p75NTR TrkA system for T cell development in human thymus during senile involution . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Peptidomimetics of the loop 1 domain prevent death via p75NTR dependent signaling and peptidomimetics of the loop 4 domain prevent death via Trk related signaling . ^^^ Ongoing studies will determine whether these compounds act via p75NTR or Trk receptors . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Postganglionic sympathetic neurons , which are exquisitely sensitive to small changes in levels of target derived nerve growth factor ( NGF ) , express two transmembrane receptors : 1 ) the trkA receptor mediates neuron survival and neurite outgrowth ; and 2 ) the p 75 neurotrophin receptor ( p75NTR ) enhances neuronal responsiveness of trkA to NGF . ^^^ Elevating levels of NGF induces several morphological and neurochemical alterations in sympathetic neurons , including axonal sprouting , increased levels of p75NTR mRNA relative to trkA mRNA , and increased accumulations of NGF in hypertrophied somata . ^^^ In 5 week old SHR , levels of both p75NTR and trkA mRNA in mesenteric sympathetic neurons were significantly elevated compared to levels in age matched control rats . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
PC 12 cells express two types of membrane receptor for NGF : TrkA receptors and p75NTR receptors , and it was not clear from our studies which receptor was responsible . ^^^ We show here that brain derived neurotrophic factor , which activates p75NTR but not TrkA receptors , does not stimulate GSK3beta phosphorylation of MAP1B in PC 12 cells . ^^^ Similarly , NGF fails to activate GSK3beta phosphorylation of MAP1B in PC 12 cells that lack TrkA receptors but express p75NTR receptors ( PC 12 nnr ) . ^^^ Chick ciliary ganglion neurons in culture lack TrkA receptors but express p75NTR and also fail to show NGF dependent GSK3beta phosphorylation of MAP1B , whereas in rat superior cervical ganglion neurons in culture , NGF activation of TrkA receptors elicits GSK3beta phosphorylation of MAP1B . ^^^ These results suggest that the activation of GSK3beta by NGF is mediated through the TrkA tyrosine kinase receptor and not through p75NTR receptors . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
However , the spontaneous regression of neuroblastoma mimics the programmed cell death normally occurring in developing sympathetic cells expressing both TrkA tyrosine kinase A and p75NTR neurotrophin receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The presence of neurotrophins and the neurotrophin receptors p 75 ( p75NTR ) , tyrosine kinase A ( TrkA ) , TrkB and TrkC have been described in several immune cells . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In immunohistochemical studies , we found that keratinocytes in lesional and nonlesional psoriatic tissue express high levels of nerve growth factor ( NGF ) and that there is a marked upregulation of NGF receptors , p 75 neurotrophin receptor ( p75NTR ) and tyrosine kinase A ( TrkA ) , in the terminal cutaneous nerves of psoriatic lesions . ^^^ These observations , as well as recent findings about NGF induced chemokine expression in keratinocytes , further substantiate a role of the NGF p75NTR TrkA system in the inflammatory process of psoriasis . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
This article will describe how neurotrophin receptors , Trk and p 75 neurotrophin receptor ( p75NTR ) , are intimately involved in the axonal transport process . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The common neurotrophin receptor p75NTR enhances the ability of PC 12 cells to resist oxidative stress by a trkA dependent mechanism . ^^^ Many studies have demonstrated that p75NTR can enhance nerve growth factor induced survival mediated via the trkA receptor . ^^^ These data suggest that p75NTR enhances the ability of PC 12 cells to resist oxidative stress by a trkA dependent mechanism , potentially by allosteric mechanisms . ^^^ Further , potential trkA independent and pro apoptotic signaling of p75NTR does not contribute to apoptotic cell death of PC 12 cells in a setting of oxidative insult . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Inhibition could be mediated by either the p75NTR or TrkA receptor . ^^^ High dose NGF may induce cytoplasmic relocation of the receptor TrkA and axonal growth arrest independently of p75NTR . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
NGF regulates cell survival and cell death via binding to two different receptors , TrkA and p75NTR ( ref . 10 ) . ^^^ In contrast , proNGF selectively induces apoptosis through p75NTR but not TrkA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Neurotrophin effects on neuroblastoma cells : correlation with trk and p75NTR expression and influence of Trk receptor bodies . ^^^ Neurotrophins ( NTs ) bind to two different classes of cell surface receptors , Trk receptor tyrosine kinases and p75NTR , both of which are expressed by neuroblastoma cells . ^^^ NGF increased proliferation of Neuro 2a cells , which express p75NTR but no TrkA receptors on their surface . ^^^ On the other hand , SK N BE cell proliferation was decreased after NGF treatment , even though these cells also express p75NTR but no TrkA receptors on their surface . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The Ig like domains of Trk receptors and the cysteine rich repeats of p75NTR are involved in binding to the neurotrophins . ^^^ Here we show that NRH 2 is expressed in several neuronal populations that also express p75NTR and Trk receptors . ^^^ These results indicate that a transmembrane protein related to p75NTR is capable of modulating Trk receptor binding properties . . ^^^ Nerve growth factor ( NGF ) functions as a ligand for two receptors , the TrkA tyrosine kinase receptor and the p 75 neurotrophin receptor ( p75NTR ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
However , it is unclear whether the NGF high affinity receptor tyrosine kinase A ( TrkA ) and the NGF low affinity receptor p75NTR are altered in the state of sympathetic hyperinnervation in the heart . ^^^ The aim of this study was to determine the density and location of TrkA and p75NTR in canine ventricles with sympathetic hyperinnervation . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
This study examined the effects of hypomorphic p 75 neurotrophin receptor ( p75NTR ) expression and high levels of nerve growth factor ( NGF ) on trkA phosphorylation and downstream activation of p44 / 42 mitogen activated protein kinase ( MAPK ) . ^^^ These data provide new insight into the mechanism underlying enhanced neurite outgrowth in p 75 ( / ) neurons , demonstrating that trkA and MAPK signalling in sympathetic neurons are increased when p75NTR function is disrupted . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Compared to TrkA , the function of p75NTR in nerve growth factor ( NGF ) endocytosis is less clear , and it is unknown whether p75NTR by itself may internalize other neurotrophins besides NGF . ^^^ We directly compared TrkA and p75NTR for their ability to internalize NGF , and we also examined the endocytosis of iodinated brain derived neurotrophic factor ( BDNF ) and neurotrophin 3 ( NT 3 ) by p75NTR . ^^^ Cells expressing solely TrkA internalized NGF more efficiently than cells expressing p75NTR . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
By real time PCR and immunohistochemistry , stress exposed mice showed an up regulation of NGF and its low affinity receptor p75NTR ; the NGF high affinity receptor TrkA was moderately down regulated . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
This interest is based on the observation that CBF neurons , which provide the major source of cholinergic innervation to the cerebral cortex and hippocampus , undergo selective and severe degeneration in advanced AD and that the survival of CBF neurons depends upon NGF and its receptors , namely , trkA and p75NTR . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
To discriminate these effects we used two p75NTR receptor positive lines of cholinergic neuroblastoma cells , SN 56 and T 17 that are devoid of or express high affinity NGF ( TrkA ) receptors , respectively . cAMP and retinoic acid caused differentiation of both cell lines . ^^^ Data indicate that : ( 1 ) positive cholinotrophic effects of NGF required activation of both TrkA and p75NTR receptors ; ( 2 ) cAMP / RA evoked differentiation inhibited NGF effects mediated by TrkA receptors and activated its p75NTR dependent suppressing influences and ( 3 ) a differentiation evoked decrease of mitochondrial acetyl CoA and an elevation of mitochondrial Ca could augment impairment of cholinergic neurons by neurotoxic signals . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Functional interaction between p75NTR and TrkA : the endocytic trafficking of p75NTR is driven by TrkA and regulates TrkA mediated signalling . ^^^ However , information is still scarce about the role of the cellular localization of the TrkA co receptor , p75NTR ( where NTR is neurotrophin receptor ) , following stimulation by NGF . ^^^ In FRT ( Fischer rat thyroid ) cells , endogenous TrkA is localized exclusively on the basolateral surface , while transfected p75NTR is selectively distributed on the apical membrane . ^^^ This cellular system enabled us to selectively stimulate either p75NTR or TrkA and to analyse the role of receptor trafficking in their signalling capability . ^^^ We found that , after binding to NGF , p75NTR was co immunoprecipitated with TrkA and was transcytosed at the basolateral membrane . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
This prototypical neurotrophic factor stimulates neurons through two distinct classes of membrane receptors : the TrkA tyrosine kinase receptor , and the tumor necrosis factor receptor family member p75NTR , also known as the common neurotrophin receptor . ^^^ Both the survival and proliferation of breast cancer cells are strongly stimulated by NGF , mediated by TrkA and p75NTR respectively , utilising signaling pathways similar to those described for neurons . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Collectively , our results suggest that localized sources of NGF can direct axon outgrowth from trigeminal ganglion in a dose and age dependent fashion , mediated by p75NTR signaling through TrkA expressing axons . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The Trk family of receptor tyrosine kinases and the p 75 receptor ( p75NTR ) mediate the effects of neurotrophins on neuronal survival , differentiation and synaptic plasticity . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Because SCN neurons do not express TrkA , NGF might have exerted its effects either through direct signalling of the neurons via p75NTR or by enhancing the activity of the cholinergic afferents to the SCN , which arise from the nucleus basalis magnocellularis ( NBM ) . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We investigated expression of NGF and its receptors , TrkA and p75NTR , in hepatocellular carcinomas ( HCCs ) . ^^^ TrkA was detected in the smooth muscle cells of hepatic arteries , but it was negative in tumor cells as well as non neoplastic hepatocytes . p75NTR and alpha smooth muscle actin ( alphaSMA ) was expressed in HSCs in the background liver and fibroblast like cells in stromal septa , whereas HSCs within the HCC tissues were mostly negative for p75NTR but positive for alphaSMA . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The secreted brain derived neurotrophic factor precursor pro BDNF binds to TrkB and p75NTR but not to TrkA or TrkC . ^^^ A furin resistant pro BDNF , secreted from COS 7 cells , bound to TrkB Fc and p75NTR Fc , but not to TrkA Fc or TrkC Fc . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Differential endocytic sorting of p75NTR and TrkA in response to NGF : a role for late endosomes in TrkA trafficking . ^^^ NGF binds to two receptors , p75NTR and TrkA . ^^^ Both p75NTR and TrkA were internalized in response to NGF and colocalized with early endosomes . ^^^ However , surprisingly , the subsequent endosomal trafficking paths of both NGF receptors diverged : whereas p75NTR recycled back to the surface , TrkA moved to late endosomes and underwent lysosomal degradation . ^^^ Disrupting p75NTR recycling diminished TrkA activation in response to low concentrations of NGF , demonstrating a functional role for the recycling of p75NTR . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Dysfunction of nerve growth factor ( NGF ) and its high ( TrkA ) and low ( p75NTR ) affinity receptors has been suggested to underlie the selective degeneration of the nucleus basalis ( NB ) cholinergic cortical projection neurons in end stage Alzheimer disease ( AD ) . ^^^ Moreover , there is a loss of cortical TrkA in the face of stable p75NTR and increased proNGF levels , the precursor molecule of mature NGF , in early AD . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
As a first step toward exploring this , we studied in murine back skin ( C57BL / 6 ) whether intradermally injected interleukin 1beta ( IL 1beta ) , tumor necrosis factor alpha ( TNF alpha ) , and interferon gamma ( IFN gamma ) altered the cutaneous immunoreactivity patterns of nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) , neurotrophin 3 ( NT 3 ) , neurotrophin 4 ( NT 4 ) , Trk A , Trk B , Trk C and p75NTR and their receptors ( TrkA , TrkB , TrkC , p75NTR ) on the protein level in situ . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Because previous studies have revealed a bidirectional mode of neurotrophin action by virtue of signaling through either the neurotrophin receptor p75NTR or the Trk receptors , we tested the hypothesis that p75NTR is important for longterm depression ( LTD ) to occur . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Differential actions of nerve growth factor receptors TrkA and p75NTR in a rat model of epileptogenesis . ^^^ Kindling , an experimental model of epileptogenesis , and activation induced synaptic reorganization are modulated by nerve growth factor ( NGF ) , but whether NGF acts via its high affinity receptor TrkA and / or the common neurotrophin receptor p75NTR is unknown . ^^^ We previously demonstrated , and confirmed in this study , that inhibition of NGF binding to both TrkA and p75NTR inhibited kindling and decreased kindling induced mossy fiber sprouting . ^^^ Our results suggest that TrkA , but not p75NTR , plays a role in kindling , while both receptors modulate kindling induced mossy fiber sprouting . ^^^ This implicates different mechanisms of neurotrophin action on kindling ( mediated by TrkA ) and neuronal sprouting ( mediated by both TrkA and p75NTR ) and suggests that sprouting involves kindling independent neurotrophin action via p75NTR . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
We showed that aorta endothelial cells express mRNA for both the receptor tyrosine kinase TrkA and the p 75 neurotrophin receptor ( p75NTR ) that associates with TrkA when signalling occurs . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
A TrkA to p75NTR molecular switch activates amyloid beta peptide generation during aging . ^^^ In the present study , we show that two members of the neurotrophin receptor superfamily , TrkA ( tyrosine kinase receptor A ) and p75NTR ( p 75 neurotrophin receptor ) , differentially regulate the processing of APP ( amyloid precursor protein ) : TrkA reduces , whereas p75NTR activates , beta cleavage of APP . ^^^ We also show that normal aging activates Abeta generation in the brain by ' switching ' from the TrkA to the p75NTR receptor system . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In rat pheochromocytoma ( PC 12 ) cells , tyrosine kinase A receptor ( TrkA ) mediates neurotrophic or protective effects , while p 75 neurotrophin receptor ( p75NTR ) functions as a death receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Factors limiting the therapeutic application of neurotrophin proteins include their poor pharmacological properties and their pleiotropic effects mediated by interaction with Trk , p75NTR and sortilin receptors . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
TrkA and p75NTR in the ovary of adult cow and pig . ^^^ In this study we investigated the cell localization of the two main receptors for nerve growth factor ( NGF ) , TrkA and p75NTR , in the cow and pig ovary , using immunohistochemistry . ^^^ Specific immunoreactivity for TrkA and p75NTR was detected in the ovary of both species , but the pattern and intensity of immunostaining were marginally different between them . ^^^ Taken together , these results suggest a possible direct role of NGF on oocytes expressing TrkA and p75NTR , in addition to the well known roles in other ovary functions . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Transient exposure of the cells to 200 microM H2O2 triggered a significant reduction of cell viability and decreased the mRNA and protein levels of NGF , neurotrophin receptor P 75 ( P75NTR ) receptor and tyrosine kinase A ( TrkA ) receptor . ^^^ Incubation of cells with 10 microM huperzine A prior to H2O2 exposure significantly elevated their survival and restored the mRNA and protein levels of NGF , P75NTR receptor and TrkA receptor . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Survival and growth of sympathetic neurons is regulated by nerve growth factor acting through trkA and p75NTR receptors . ^^^ To determine if estrogen may influence sympathetic neurons via altered neurotrophin receptor expression , we investigated effects of acute or chronic estrogen administration on levels of trkA and p75NTR proteins , numbers of immunoreactive neurons , and numbers of neurons expressing trkA , p75NTR , and estrogen receptor alpha transcripts . ^^^ Reduced trkA expression after acute estrogen may transiently predispose neurons to degenerative events , while diminished p75NTR expression by chronic estrogen administration may exert long term effects on survival or axonal outgrowth in sympathetic neurons . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Furthermore , cells transfected with chimeric TNFalpha / NGF receptors demonstrated that the simultaneous presence of both p75NTR and TrkA signaling is necessary to synergize with TNFalpha to mediate iNOS expression . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
These results show that p75NTR negatively modulates dendritic morphology in adult hippocampal pyramidal neurons and documents a new case of functional antagonism between Trk and p75NTR signaling . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The functional effects of nerve growth factor ( NGF ) and its precursor , pro NGF , are thought to be mediated through binding of these ligands to one or both of their receptors , TrkA and p75NTR . ^^^ While the signaling pathways and downstream effects of NGF binding to TrkA are reasonably well known , those related to the binding of NGF and pro NGF to p75NTR are less well understood . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Expression of p75NTR and Trk neurotrophin receptors in the enteric nervous system of human adults . ^^^ Recent evidence suggests that the expression of p75NTR and Trk neurotrophin receptors is essential for neuronal survival , not only during development , but also in adulthood . ^^^ The aim of the present study was to investigate the cell localization and distribution of p75NTR and Trk receptors in the normal adult human enteric nervous system ( ENS ) using double label immunohistochemistry . ^^^ Immunoreactivity for p75NTR was observed in a few neurons , whereas Trk immunoreactivity was present in a higher percentage of neurons . ^^^ Furthermore , polynuclear cells , mast cells and folliculoreticular cells in the germinal layer of lymph nodes displayed p75NTR and / or Trk immunopositivity . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
In the present study , we have investigated the expression profile of neurotrophins NGF , BDNF and NT 3 and their high affinity ( TrkA , TrkB , TrkC ) and common low affinity ( p75NTR ) receptors before and during neural differentiation of rat BMSCs by RT PCR . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
The thymic stromal cells in the rat express the high ( TrkA , TrkB ) and low affinity ( p75NTR ) receptors for neurotrophins . ^^^ In this study we analysed the regulation of TrkA , TrkB and p75NTR expression in the rat thymus by thymocytes . ^^^ We observed massive thymocyte apoptosis 1 day after injection and , to a lesser extent , after 4 days , which was parallel with a reduction in the density of thymic epithelial cells normally expressing TrkA and p75NTR . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Under normal conditions , expression of the p 75 neurotrophin receptor ( p75NTR ) by sympathetic neurons can increase the affinity of the signaling receptor , trkA , to target derived nerve growth factor ( NGF ) at distal axons . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer ' s disease . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Differential expression of the neurotrophin receptors p75NTR , TrkA , TrkB and TrkC in human peripheral blood mononuclear cells . ^^^ Since neurotrophin receptor surface expression is essential for neurotrophin action , the aim of our study was to systematically investigate the expression pattern of the low affinity pan neurotrophin receptor p75NTR as well as the high affinity receptors TrkA , TrkB and TrkC in human peripheral blood mononuclear cells . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Neurotrophins bind to two sets of receptors , Trk receptor tyrosine kinases and the p75NTR receptor , to activate several different signaling pathways that mediate various biological functions . ^^^ While Trk receptor activation has been well studied and triggers the well characterized Ras / Rap MAPK , PI3K Akt , and PLCgamma PKC cascades , p75NTR signaling is more complex , and its in vivo significance has not yet been completely determined . ^^^ This review will update the neurotrophin signaling pathways known for Trk receptors to include newly identified Trk interacting molecules and will address surprising new findings that suggest a role for p75NTR in different receptor complexes and functions . . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Studies showing that neurotrophin binding to p75NTR can promote cell survival in the absence of Trk ( tropomyosin related kinase ) receptors , together with recent structural data indicating that NGF may bind to p75NTR in a monovalent manner , raise the possibility that small molecule p75NTR ligands that positively regulate survival might be found . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
A recent finding indicated that a furin resistant proNGF preferentially binds to p75NTR , initiating a pro apoptotic cascade even in the presence of TrkA . ^^^ We have investigated the effect of a non mutated 32 kDa human recombinant proNGF ( rhproNGF ) on cultured pig oligodendrocytes which express TrkA , p75NTR and sortilin . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
P75NTR , but not Trk , associates with neurotrophins in lipid rafts and coimmunoprecipitates with the truncated beta caveolin 1 isoform . ^^^ Finally , we directly visualize the retrograde transport of p75NTR ligands to cell bodies , which is insensitive to inhibitors of Trk retrograde transport , suggesting mechanistic differences . ^^^ We postulate that beta caveolin 1 containing lipid rafts and possibly intracellular endosomes might be compartments to which p75NTR : BDNF complexes are trafficked separately from Trk . . ^^^ BDNF , through p75NTR , promotes apoptosis and inhibits axonal growth of sympathetic neurons , antagonizing the pro survival and axon growth promoting actions of NGF through TrkA . ^^^ While the trafficking of the TrkA : NGF complex is well characterized , little is known about p75NTR : BDNF trafficking in these neurons . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
Proneurotrophins bind with high affinity to p 75 neurotrophin receptor ( p75NTR ) and lack the capacity to bind Trk receptors , suggesting that proneurotrophins can elicit apoptosis via p75NTR even in cells expressing survival promoting Trk receptors . ^^^ Surprisingly , exposure to both mature neurotrophins and proneurotrophins demonstrated that Trk phosphorylation did not prevent pro NGF induced apoptosis via p75NTR . ^^^
Interacting proteins: P08138 and P04629	Pubmed	SVM Score :0.0
RanBPM as a novel binding protein can interact with neurotrophin receptor p75NTR and tyrosine kinase receptor Met which has a similar tyrosine kinase structure as receptor TrkA has . ^^^