| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| Using ChIP assays the binding of Stat 3 to Her 2 promoter was confirmed . ^^^ |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| METHODS : The authors analyzed c erb B 2 expression in samples obtained from the head of the pancreas from 26 patients with CP ( 5 women , 21 men ) using immunohistochemical and molecular technique . ^^^ By in situ hybridization , c erb B 2 messenger ribonucleic acid ( mRNA ) grains were expressed at high levels in patients with CP with EHP in both ductal and acinar cells . ^^^ CONCLUSIONS : These findings indicate the c erb B 2 is not overexpressed in most patients with CP . ^^^ However , its overexpression in patients with CP with EHP suggest that c erb B 2 may contribute to the pathophysiologic processes that lead to pancreatic head enlargement . . ^^^ |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| When both are normal there is a 99 % probability of not suffering CP and when both are low there is a 90 % probability of developing CP , in particular nosocomial pneumonia ( NEU ) . ^^^ |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| PATIENTS AND METHODS : Using immuno histochemistry , Mib 1 evaluated proliferative activity and expression of p 53 , Bcl 2 , c erbB 1 , c erbB 2 , cytokeratin and vimentin were analysed in 17 benign and 12 malignant CP . ^^^ |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| We now show that the chaperone binding ubiquitin ligase CHIP efficiently ubiquitinates and down regulates ErbB 2 . ^^^ CHIP expression shortens the half life of both nascent and mature ErbB 2 protein . ^^^ In vitro ubiquitination assay shows that CHIP serves as a ubiquitin ligase for ErbB 2 , and both exogenously expressed and endogenous CHIP coprecipitate with the kinase . ^^^ Furthermore , CHIP association with ErbB 2 requires a chaperone intermediate and is increased by the chaperone binding drug geldanamycin , a potent stimulator of ErbB 2 ubiquitination and degradation . ^^^ |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| ErbB 2 degradation mediated by the co chaperone protein CHIP . ^^^ Here , we show that ErbB 2 serves as an in vitro substrate for the Hsp70 / Hsp90 associated U box ubiquitin ligase CHIP . ^^^ Overexpression of wild type CHIP , but not its U box mutant H260Q , induced ubiquitinylation and reduction in both cell surface and total levels of ectopically expressed or endogenous ErbB 2 in vivo , and this effect was additive with that of 17 allylamino geldanamycin ( 17 AAG ) . ^^^ The CHIP U box mutant H260Q reduced 17 AAG induced ErbB 2 ubiquitinylation . ^^^ Wild type ErbB 2 and a mutant incapable of association with Cbl ( ErbB 2 Y1112F ) were equally sensitive to CHIP and 17 AAG , implying that Cbl does not play a major role in geldanamycin induced ErbB 2 down regulation . ^^^ |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| METHODS : Using streptavidinbiotin complex ( SABC ) method , c erbB 2 oncongene protein , we examined immunohistochemically EGFR and TGF beta 1 expressions in wax tissue sections from 10 individuals with normal pancreas ( NP ) , 13 patients with chronic pancreatitis ( CP ) and 36 patients with pancreatic ductal adenocarcinoma ( PC ) . ^^^ |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| Because protein degradation is required for healthy cellular function , CHIP ' s ability to degrade proteins that are the signature of disease , eg , ErbB 2 in breast and ovarian cancers , could prove to be a point of therapeutic intervention . . ^^^ |
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| Interacting proteins: Q9UNE7 and P04626 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to compare the prevalence of K ras and c erbB 2 mutations in PA and CP in order to evaluate their usefulness in differential diagnosis of those diseases . ^^^ Prevalence of c erbB 2 amplification in patients with PA was 17 ( 65 . 3 % ) , which was not different from CP , 16 ( 56 . 5 % ) ( p=0 . 58 ) . ^^^ CONCLUSION : Those results may indicate that both K ras and c erbB 2 play a role in pancreatic carcinogenesis , however only K ras may provide an additional tool in differential diagnosis of CP and PC . . ^^^ |
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