| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.90625222 |
| PURPOSE : To show the presence and localization of type 1 growth factor receptors ( ErbB 2 , ErbB 3 and ErbB 4 ) in rat corneal and conjunctival epithelia and investigate the association of ErbB 2 with its intramembrane ligand Muc 4 . 0.90625222^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.64501105 |
| Since rat Muc 4 was shown to interact with ErbB 2 tyrosine kinase receptor and to either promote cell survival and differentiation or cell proliferation , it is postulated that MUC 4 may also participate in pancreatic carcinogenesis . 0.64501105^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| Sialomucin complex ( SMC , Rat Muc 4 ) is a heterodimeric glycoprotein complex consisting of a mucin subunit ASGP 1 ( ascites sialoglycoprotein 1 ) and a transmembrane subunit ASGP 2 , which can act as a ligand for the receptor tyrosine kinase ErbB 2 . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| Decreased interaction between trastuzumab and its target receptor HER 2 , which is due to steric hindrance of HER 2 by cell surface proteins such as mucin 4 ( MUC 4 ) , may block the inhibitory actions of trastuzumab . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| The relative expression of mucin antigens MUC 1 , MUC 2 , MUC 3 , MUC 4 , MUC5AC , MUC5B , and MUC 7 and glycoprotein antigens KSA , carcinoembryonic antigen , prostate specific membrane antigen ( PSMA ) , HER 2 / neu , and human chorionic gonadotropin beta on different cancers and normal tissues is difficult to determine from available reports . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| These results confer a new biological role for MUC 4 as a ligand for ErbB 2 in cell signalling . . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| The homology of MUC 12 with epidermal growth factor like growth factors and its down regulation in colorectal cancers , together with known interactions between rat MUC 4 and c erbB 2 growth factor receptors , suggests that MUC 12 may be involved in epithelial cell growth regulation . . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| Second , MUC 4 can bind the receptor tyrosine kinase ErbB 2 and alter its cellular signaling . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| Although no soluble ligand has been identified for ErbB 2 , we have recently shown that ASGP 2 , the transmembrane subunit of the cell surface glycoprotein Muc 4 ( also called sialomucin complex , SMC ) , can act as an intramembrane ligand for ErbB 2 and modulate its activity . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To show the presence and forms of sialomucin complex ( rat Muc 4 ) and receptor tyrosine kinase ErbBs in the rat lacrimal gland and analyze for complexes of ErbB 2 and its ligand Muc 4 . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| Rat Muc 4 ( sialomucin complex ) reduces binding of anti ErbB 2 antibodies to tumor cell surfaces , a potential mechanism for herceptin resistance . ^^^ Using A 375 human melanoma cells and MCF 7 human breast adenocarcinoma cells stably transfected with tetracycline regulatable Muc 4 , we have investigated whether overexpression of Muc4 / SMC can repress antibody binding to cell surface expressed ErbB 2 . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| In this context , we investigated whether neutrophil elastase may regulate expression of MUC 4 , a membrane tethered mucin that has recently been identified as a ligand for ErbB 2 , the major heterodimerization partner of the epidermal growth factor receptor . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| MUC 4 is a novel intramembrane ligand for the receptor tyrosine kinase ErbB2 / HER2 / Neu , triggering a specific phosphorylation of the ErbB 2 in the absence of other ErbB ligands and potentiating phosphorylation and signaling through the ErbB2 / ErbB3 heterodimeric receptor complex formed in the presence of neuregulin . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| ErbB 2 and its ligand Muc 4 ( sialomucin complex ) in rat lacrimal gland . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| Due to the size , glycosylation , and location in the plasma membrane of the sialomucin complex Muc 4 , which has been implicated in ErbB 2 signaling , in the repression of apoptosis and cell adhesion , and in tumor metastasis , studies were initiated to determine whether its presence could influence cell sensitivity to anticancer drugs . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| Because MUC 4 is an intramembrane ligand for receptor tyrosine kinase ErbB 2 and is related with regulation of p 27 , we also compared the MUC 4 expression with ErbB 2 and p 27 expressions in ICC MFs . ^^^ The patients with MUC 4 and ErbB 2 double positive expression showed a short survival period compared to non expressing patients . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| MUC 4 and ERBB 2 expression in major and minor salivary gland mucoepidermoid carcinoma . ^^^ This study investigates MUC 4 and ErbB 2 receptor expression in major and minor salivary gland mucoepidermoid carcinoma and correlates patterns of expression with clinical outcomes . ^^^ METHODS : MUC 4 antigens and ErbB 2 receptor expression are localized by immunohistochemical studies that use archival formalin fixed and paraffin embedded tissue . ^^^ MUC 4 antigen positivity is seen in two of the five cases with 2+ and 3+ staining for ErbB 2 . ^^^ Although limited by small sample size , analysis reveals ErbB 2 overexpression is not consistently associated with MUC 4 antigen positivity and might be associated with increased risk of death . . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| A role for human MUC 4 mucin gene , the ErbB 2 ligand , as a target of TGF beta in pancreatic carcinogenesis . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| Decreased accessibility and lack of activation of ErbB 2 in JIMT 1 , a herceptin resistant , MUC 4 expressing breast cancer cell line . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| METHODS : The expression profiles of MUC 4 , ErbB 2 , p 27 , and MUC 1 were investigated in IDC tissues from 135 patients by means of immunohistochemistry . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Recent studies have identified MUC 4 mucin as a ligand for activation of ErbB 2 , a receptor tyrosine kinase that modulates epithelial cell proliferation following epithelial damage in airways of asthmatics . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| Muc 4 ErbB 2 complex formation and signaling in polarized CACO 2 epithelial cells indicate that Muc 4 acts as an unorthodox ligand for ErbB 2 . ^^^ Muc 4 serves as an intramembrane ligand for the receptor tyrosine kinase ErbB 2 . ^^^ The time to complex formation and the stoichiometry of the complex were determined to be < 15 min and 1 : 1 by analyses of Muc 4 and ErbB 2 coexpressed in insect cells and A 375 tumor cells . ^^^ In polarized CACO 2 cells , Muc 4 expression causes relocalization of ErbB 2 , but not its heterodimerization partner ErbB 3 , to the apical cell surface , effectively segregating the two receptors . ^^^ The ability of Muc 4 to segregate ErbB 2 and other ErbB receptors and to alter downstream signaling cascades in polarized epithelial cells suggests that it has a role in regulating ErbB 2 in differentiated epithelia . . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| MUC 4 and ErbB 2 expression in squamous cell carcinoma of the upper aerodigestive tract : correlation with clinical outcomes . ^^^ MUC 4 modulates cell signaling pathways as an intramembrane ligand of ErbB 2 . ^^^ The hypotheses of the study were that MUC 4 expression would correlate with ErbB 2 expression and that MUC 4 expression would correlate with clinical outcomes in squamous cell carcinoma of the upper aerodigestive tract . ^^^ METHODS : MUC 4 and ErbB 2 receptor expression was localized by immunohistochemical studies using archival formalin fixed and paraffin embedded tissue . ^^^ Membrane expression of MUC 4 and ErbB 2 was seen in 12 % and 13 % of tumors , respectively . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| Expression , location , and interactions of ErbB 2 and its intramembrane ligand Muc 4 ( sialomucin complex ) in rat mammary gland during pregnancy . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| Moreover , an emphasis is placed on the importance of critical signaling pathways and postulated interactions , including those of ErbB 2 , hepatocyte growth factor / Met , interleukin 6 / glycoprotein130 , cyclooxygenase 2 , vascular endothelial growth factor , transforming growth factor beta , MUC 1 and MUC 4 , beta catenin , telomerase , and Fas pathways as potential molecular therapeutic targets in cholangiocarcinoma . . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| MUC 4 expression and its relation to ErbB 2 expression , apoptosis , proliferation , differentiation , and tumor stage in non small cell lung cancer ( NSCLC ) . ^^^ MUC 4 and ErbB 2 mediate intracellular signaling pathways that are linked to repression of apoptosis and either to proliferation or to differentiation of tumor cells . ^^^ This study investigates the expression of human MUC 4 in neoplastic and corresponding non neoplastic tissues , and the relation of MUC 4 expression in neoplastic tissues to ErbB 2 expression , apoptosis , proliferation , differentiation , and tumor stage in a series of 100 non small cell lung carcinomas ( NSCLCs ) . ^^^ MUC 4 and ErbB 2 expressions and cell proliferation ( PCNA ) were shown using immunohistochemistry . ^^^ MUC 4 expression was inversely correlated with AI ( p=0 . 0002 ) and was correlated with ErbB 2 expression ( p=0 . 022 ) , but not with PCNA counts and tumor stage . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| The mucin Muc 4 potentiates neuregulin signaling by increasing the cell surface populations of ErbB 2 and ErbB 3 . ^^^ We have previously demonstrated that Muc 4 , a transmembrane mucin that promotes tumor growth and metastasis , physically interacts with the ErbB 2 receptor tyrosine kinase and augments receptor tyrosine phosphorylation in response to the neuregulin 1beta ( NRG1beta ) growth factor . ^^^ In examining the mechanism underlying Muc 4 potentiated ErbB 2 signaling , we found that Muc 4 expression markedly augments NRG1beta binding to A 375 cells without altering the total quantity of receptors expressed by the cells . ^^^ Cell surface protein biotinylation experiments and immunofluorescence studies suggest that Muc 4 induces the relocalization of the ErbB 2 and ErbB 3 receptors from intracellular compartments to the plasma membrane . ^^^ |
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| Interacting proteins: Q99102 and P04626 |
Pubmed |
SVM Score :0.0 |
| MUC 4 , a large molecular weight membrane bound glycoprotein , has recently been identified as a potential ligand for the ErbB 2 receptor . ^^^ |
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