| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.57091923 |
| Using as bait the ErbB 2 C terminus , we identified Erbin , another PDZ domain containing protein that interacts specifically with ErbB 2 . 0.57091923^^^ |
|
| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.62295335 |
| ErbB 4 associates with the PSD 95 ( also known as SAP 90 ) family members including PSD 95 , SAP 97 , and SAP 102 whereas ErbB 2 interacts with Erbin and PICK 1 . 0.62295335^^^ |
|
| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| We have identified a new PDZ protein we named ERBIN ( ERBB 2 interacting protein ) that acts as an adaptor for the receptor ERBB2 / HER2 in epithelia . ^^^ |
|
| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : ERBIN , an ErbB 2 receptor interacting protein , belongs to a recently described family of proteins termed the LAP [ leucine rich repeats and PSD 95 / dLg A / ZO 1 ( PDZ ) domains ] family which has essential roles in establishment of cell polarity . ^^^ |
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| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| Basolateral targeting of ERBB 2 is dependent on a novel bipartite juxtamembrane sorting signal but independent of the C terminal ERBIN binding domain . ^^^ Furthermore , we find that the C terminal ERBIN binding domain of ERBB 2 is not necessary for its basolateral targeting in MDCK cells . . ^^^ |
|
| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| We also confirmed that the interaction with p 0071 was not essential for the membrane targeting of ERBIN , a recently identified p 0071 and ErbB 2 binding protein . ^^^ Furthermore , ERBIN and ErbB 2 were colocalized with PAPIN on the lateral membrane . ^^^ |
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| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| Although it interacts with the ErbB 2 C terminus through the PDZ domain , Erbin has no effect on ErbB 2 tyrosine phosphorylation or binding to the adaptor proteins Shc and Grb 2 . ^^^ |
|
| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| Erbin contains a class 1 PDZ domain that binds to the C terminal region of the receptor tyrosine kinase ErbB 2 , a class 2 ligand . ^^^ The crystal structure of the human Erbin PDZ bound to the peptide EYLGLDVPV corresponding to the C terminal residues 1247 1255 of human ErbB 2 has been determined at 1 . 25 A resolution . ^^^ The isopropyl group of valine at position 2 of the ErbB 2 peptide interacts with the Erbin Val ( 1351 ) and displaces the peptide backbone away from the alpha helix , elucidating the molecular basis of class 2 ligand recognition by a class 1 PDZ domain . ^^^ Phosphorylation of tyrosine 7 abolishes this interaction but does not affect the binding of the four C terminal peptidic residues to PDZ , as revealed by the crystal structure of the Erbin PDZ complexed with a phosphotyrosine containing ErbB 2 peptide . ^^^ Since phosphorylation of tyrosine 7 plays a critical role in ErbB 2 function , the selective binding and sequestration of this residue in its unphosphorylated state by the Erbin PDZ provides a novel mechanism for regulation of the ErbB 2 mediated signaling and oncogenicity . . ^^^ |
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| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| Erbin : sorting out ErbB 2 receptors or giving Ras a break . ^^^ |
|
| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| Delineation of the translocation breakpoints showed that the ERBB2IP ( erbb 2 interacting protein or Erbin ) gene is disrupted in 5q13 . 1 and GPC 6 in 13q32 . ^^^ |
|
| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| Our data further indicate that the endocytosis deficiency of ErbB 2 and of EGFR ErbB 2 heterodimers / oligomers can not be explained by anchoring of ErbB 2 to PDZ containing proteins such as Erbin . ^^^ |
|
| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| The product of rat gene 33 was identified as an ErbB 2 interacting protein in a two hybrid screen employing the ErbB 2 juxtamembrane and kinase domains as bait . ^^^ |
|
| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| The ErbB 2 interacting protein receptor associated late transducer ( RALT ) was previously identified as a feedback inhibitor of ErbB 2 mitogenic signals . ^^^ |
|
| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96RT1 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|