| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.67564305 |
| In addition , upon HRG stimulation of T47D cells , association of ErbB 2 with RAFTK was observed and found to be indirect and mediated by Src . 0.67564305^^^ |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| In contrast , the concurrent activation of MAPK and PKB / Akt by EGF treatment led to an inhibition of proliferation in SK BR 3 and can be attributed to missing EGFR / c erbB 2 heterodimers . ^^^ |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| However , expression of Gab 2 mutated at this site ( S159A Gab 2 ) not only enhanced HRG induced Gab 2 tyrosine phosphorylation and association with Shc and ErbB 2 , but also markedly increased tyrosine phosphorylation of ErbB 2 and other cellular proteins and amplified activation of the ERK and PKB pathways . ^^^ |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| However , we could also show that downstream of phosphoinositide 3 kinase ( PI3K ) , protein kinase B ( PKB ) acted as a previously unknown , potent inhibitor of integrin function and mediator of the disruptive effects of c erbB 2 on adhesion and morphogenesis . ^^^ The integrin linked kinase , previously identified as a PKB coactivator , was also found to be required for integrin inactivation by c erbB 2 . ^^^ In addition , the PI3K dependent mTOR / S6 kinase pathway was shown to mediate c erbB 2 induced inhibition of adhesion ( but not spreading ) independently of PKB . ^^^ Overexpression of MEK 1 or PKB suppressed adhesion without requirement for c erbB 2 activation , suggesting that these two pathways partake in integrin inhibition by targeting common downstream effectors . ^^^ |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| PKB mediates c erbB 2 induced epithelial beta 1 integrin conformational inactivation through Rho independent F actin rearrangements . ^^^ |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| Intriguingly , the transfection and increased expression of the prognostically significant HER 2 / neu PTK induced a selective increase in the expression of the PTP alpha , PTP 1B , and PTP H 1 tyrosine phosphatases . . ^^^ |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| The receptor ( R ) for epidermal growth factor ( EGF ) is expressed at high levels on human breast cancer cells and associates with ErbB 2 , ErbB 3 , and Src proto oncogene family protein tyrosine kinases ( PTKs ) to form membrane associated PTK complexes with pivotal signaling functions . ^^^ |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| Modification of any one of three transmembrane protein tyrosine kinase ( PTK ) genes , old 1 , old 2 ( formerly tkr 1 and tkr 2 , respectively ) , and daf 2 can extend the mean and maximum life span of the nematode Caenorhabditis elegans . ^^^ |
|
| Interacting proteins: Q14289 and P04626 |
Pubmed |
SVM Score :0.0 |
| HER 3 , but not HER 2 , mediates the phosphorylation of the C terminal region of PYK 2 to promote a mitogenic response through activation of the MAPK pathway . ^^^ |
|