| Interacting proteins: Q13526 and P04626 |
Pubmed |
SVM Score :0.0 |
| Clinically useful information on the probability of relapse can be added by determining c erbB 2 ( p = 0 . 02 ) and progesterone receptors ( p = 0 . 04 ) in stage 3 and tumor ploidy ( p = 0 . 04 ) in pN 1 subgroups of patients . . ^^^ |
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| Interacting proteins: Q13526 and P04626 |
Pubmed |
SVM Score :0.0 |
| PIN 1 is an E2F target gene essential for Neu / Ras induced transformation of mammary epithelial cells . ^^^ Here we demonstrate that PIN 1 expression is mediated by the transcription factor E2F and enhanced by c Neu and Ha Ras via E2F . ^^^ Furthermore , overexpression of Pin 1 not only confers transforming properties on mammary epithelial cells but also enhances the transformed phenotypes of Neu / Ras transformed mammary epithelial cells . ^^^ In contrast , inhibition of Pin 1 suppresses Neu and Ras induced transformed phenotypes , which can be fully rescued by overexpression of a constitutively active cyclin D 1 mutant that is refractory to the Pin 1 inhibition . ^^^ Thus , Pin 1 is an E2F target gene that is essential for the Neu / Ras induced transformation of mammary epithelial cells through activation of cyclin D1 . . ^^^ |
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| Interacting proteins: Q13526 and P04626 |
Pubmed |
SVM Score :0.0 |
| We have shown that Pin 1 ablation is highly effective in preventing oncogenic Neu or Ras from inducing cyclin D 1 and breast cancer in mice , although it neither affects transgene expression nor mammary gland development . ^^^ |
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