| Interacting proteins: Q03135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Reciprocal regulation of neu tyrosine kinase activity and caveolin 1 protein expression in vitro and in vivo . ^^^ Here , we examine the relationship between Neu tyrosine kinase activity and caveolin 1 protein expression in vitro and in vivo . ^^^ Our current results show that mutational activation of c Neu down regulates caveolin 1 protein expression , but not caveolin 2 , in cultured NIH 3T3 and Rat 1 cells . ^^^ Conversely , recombinant overexpression of caveolin 1 blocks Neu mediated signal transduction in vivo . ^^^ These results suggest a reciprocal relationship between c Neu tyrosine kinase activity and caveolin 1 protein expression . ^^^ |
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| Interacting proteins: Q03135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The methylation status of caveolin 1 gene had no clear relationship with age , cell grade , stage of tumor , and status of estrogen receptor , p 53 and c erbB 2 in the breast cancer tissues . ^^^ |
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| Interacting proteins: Q03135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Caveolin 1 is down regulated and inversely correlated with HER 2 and EGFR expression status in invasive ductal carcinoma of the breast . ^^^ Using a tissue microarray , caveolin 1 expression was also correlated with the expression of other antigens such as eostrogen receptor , progesterone receptor , epidermal growth factor receptor ( EGFR ) , HER 2 , beta catenin , E cadherin , p 53 , Ki 67 and with clinicopathological parameters . ^^^ Furthermore , a statistically significant inverse correlation between caveolin 1 and EGFR and HER 2 was noted ( P < 0 . 001 ) . ^^^ Caveolin 1 also shows an inverse correlation with EGFR and HER 2 , which fits with its function as a negative regulator of signal transduction . . ^^^ |
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| Interacting proteins: Q03135 and P04626 |
Pubmed |
SVM Score :0.0 |
| According to the known functions of their genes , the clusters were designated as proliferating cell ( CDC 42 , TOP2A , FGFR 3 , MYC , etc . ) , neoangiogenesis and blood cell ( LCK , VAV 1 , KDR , VEGF , MMP 9 , SYK , PTPRS , and FLT 4 ) , invasion 1 and invasion 2 ( ADAM 17 , TRPM 2 , DUSP 6 , VIM , CAV 1 , CAV 2 , JAK 1 , PTPNS 1 , FYN , and PDGFB ) , HER 2 , and PSA / PSM / HER3 . ^^^ The results suggested that , along with PSA , PSM ( FOLH 1 ) , kallikrein 2 , and a 2 macroglobulin , cell signaling genes EGFR , HER 2 , HER 3 , TOP 2 , KRT 8 , KRT 18 , VEGF , CD 44 , VIM , CAV 1 , and CAV 2 may serve as diagnostic and prognostic markers in PC . ^^^ |
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| Interacting proteins: Q03135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Further analysis by EST vNorthern and virtual microarray analysis reduced the candidate genes to six , with four down regulated genes , ANXA 1 , CAV 1 , KRT 5 and MMP 7 , and two up regulated genes , ERBB 2 and G1P3 in breast cancer . ^^^ |
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