| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.90327146 |
| In the present study , the c erbB 2 gene product was shown by far Western blotting analysis to associate directly with both beta catenin and plakoglobin through its cytoplasmic domain core region , which showed extensive homology with epidermal growth factor receptor . 0.90327146^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.66053451 |
| Dominant negative inhibition of the association between beta catenin and c erbB 2 by N terminally deleted beta catenin suppresses the invasion and metastasis of cancer cells . 0.66053451^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.66870404 |
| An attempt was made to identify the kinases that participate in the aberrant tyrosine phosphorylation , and c erbB 2 protein was found to be directly associated with beta Catenin . 0.66870404^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.63440594 |
| At the invading front of cancers , the E cadherin cell adhesion system is inactivated by tyrosine phosphorylation of beta catenin ; an oncogene product , c erbB 2 protein , is found to associate directly with beta catenin . 0.63440594^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| Wnt 1 and 2 transfectants exhibited increased uncomplexed , cytosolic beta catenin , which was not observed with PDGFB , ras or erbB 2 transfectants . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| In order to investigate the relationships of expression and tyrosine phosphorylation of cadherin catenin molecules and expression of growth factor receptor tyrosine kinase with loose cell to cell adhesion , immunohistochemical staining for E cadherin , alpha and beta catenin , phosphorylated tyrosine residues and tyrosine kinase receptors , including c erbB 2 , epidermal growth factor receptor ( EGF R ) , c met and K sam , in 17 undifferentiated and 10 differentiated type human gastric cancers was performed . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| In addition to the cell adhesion function , beta catenin , which is an intracytoplasmic cadherin binding molecule and thought to be a regulator of cadherin mediated cell adhesion function , has been proven to associate with both the growth factor receptors , including c erbB 2 , EGF receptor and k sam and APC tumor suppressor gene product . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| Rare mutations of p 53 , Ki ras , and beta catenin genes and absence of K sam and c erbB 2 amplification in N methyl N ' nitro N nitrosoguanidine induced rat stomach cancers . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| Association of the c erbB 2 gene product with the cadherin catenin complex was proven to be mediated through beta catenin and plakoglobin using an in vitro protein protein precipitation system . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| We , therefore , immunohistochemically examined the expression of E cad , alpha catenin , beta catenin , CD 44 standard ( CD44s ) , and CD 44 variants ( CD44v ) including CD44v5 , CD44v6 , CD44v7 8 , and CD44v10 in normal adult livers and in 47 cases of CC ; and the results were then correlated with tumor grade , vascular invasion , metastasis , p 53 expression , proliferative fraction ( Ki 67 labeling ) , and c erbB 2 expression . ^^^ We found that the down regulation of E cad , alpha catenin , and beta catenin expression significantly correlated with tumor high grade , but not with vascular invasion , metastasis , p 53 expression , Ki 67 labeling , or c erbB 2 expression , except for beta catenin , the down regulation of which was associated with c erbB 2 down regulation . ^^^ These results suggest that membranous expression of E cad , alpha catenin , and beta catenin is reduced in a majority of CC and this down regulation correlates with CC high grade , and that beta catenin down regulation is associated with c erbB 2 down regulation . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : Immunohistochemistry ( ABC HRP method ) was peformed for the detection of c met , E cadherin and beta catenin . c met immunoreactivity was observed in 58 % of cases and was associated with the lobular type of breast carcinomas ( P = 0 . 012 ) , low histological grade ductal carcinomas ( P = 0 . 05 ) , favourable prognostic and predictive factors such as oestrogen and progesterone receptor immunohistochemical expression and negative c erbB 2 expression ( P = 0 . 05 , P = 0 . 014 and P = 0 . 03 , respectively ) . c met immunoreactivity did not correlate with lymph node status , tumour size and stage of the disease . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| Altered expression of beta catenin and c erbB 2 in early gastric cancer . ^^^ However , it is intriguing that 12 out of 14 cases with c erbB 2 overexpression also showed altered beta catenin expression , suggesting that both molecules are involved in the development of a certain set of differentiated EGCs . . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| Paraffin embedded tumor tissues were examined for protein expression of estrogen receptor ( ER ) , PR , Ki 67 , cyclin D 1 , TP 53 , HER 2 , beta catenin , and cyclin E using immunohistochemical approaches . ^^^ After age stratification , we found a significant difference in the frequency of tumors of BRCA 1 mutation carriers diagnosed before 50 years of age compared with age matched controls that stained positive for ER ( P = 0 . 01 ) , PR ( P = 0 . 03 ) , Ki 67 ( P = 0 . 008 ) , cyclin D 1 ( P < 0 . 001 ) , HER 2 ( P = 0 . 04 ) , and beta catenin ( P = 0 . 05 ) . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| STUDY DESIGN : In this retrospective case study , we evaluated archival nasopharyngeal carcinoma specimens for patterns of expression of E cadherin , beta catenin , c erb B 2 , and Ki 67 , which have been demonstrated to be important in other tumors . ^^^ The histopathological sections were stained using an automated immunohistochemical stainer ( NexES , Ventana Medical Systems , Tucson , AZ ) for E cadherin ( Zymed Laboratories [ San Francisco , CA ] and Transduction Laboratories [ Lexington , KY ] clones ) , beta catenin ( Zymed ) , c erb B 2 ( Ventana Medical Systems ) , and Ki 67 ( Novocastra , Burlingame , CA ) . ^^^ In contrast to recent studies , beta catenin expression is not altered and c erb B 2 expression not identified , suggesting that these markers are not important in the prognosis of nasopharyngeal carcinoma . . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| Pro oncogenic factors that also release beta catenin from the adherens complex and / or encourage translocation to the nucleus include ras , epidermal growth factor ( EGF ) , c erbB 2 , PKC betaII , MUC 1 , and PPAR gamma , whereas anti oncogenic factors that also inhibit nuclear beta catenin signaling include transforming growth factor ( TGF ) beta , retinoic acid , and vitamin D . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| In addition , c erbB 2 oncoprotein causes disruption of this cell adhesion system through beta catenin phosphorylation . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| Our data suggest that E6 / E7 cooperate with ErbB 2 in head and neck carcinogenesis , at least in part , via the conversion of beta catenin from a cell adhesion to a nuclear function , that is , to act as a potential transcriptional regulator . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical studies included the analysis of p 53 , c Met , c erbB 2 , beta catenin , and cyclooxygenase 2 . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| Moreover , an emphasis is placed on the importance of critical signaling pathways and postulated interactions , including those of ErbB 2 , hepatocyte growth factor / Met , interleukin 6 / glycoprotein130 , cyclooxygenase 2 , vascular endothelial growth factor , transforming growth factor beta , MUC 1 and MUC 4 , beta catenin , telomerase , and Fas pathways as potential molecular therapeutic targets in cholangiocarcinoma . . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| MMP 7 was studied along with clinicopathological parameters , disease free and overall survival , and p 53 , c erbB 2 , topoIIa , MMP 2 , uPAR and beta catenin . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| Mammary tissue and tumors from 5 different Wnt pathway activated transgenic mouse strains and 5 different ErbB 2 pathway activated transgenic mouse strains were studied for the amount and distribution of expression of beta catenin and LEF 1 . ^^^ LEF 1 was strongly expressed , and beta catenin had nuclear localization , in mammary tumors derived from Wnt pathway transgenic mice but not in ErbB 2 pathway transgenic mice . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| To study phenotype genotype correlations , ErbB / Ras pathway tumors ( transgenic for ErbB 2 , c Neu , mutants of c Neu , polyomavirus middle T antigene ( PyV mT ) , Ras , and bi transgenic for ErbB2 / Neu with ErbB 3 and with progesterone receptor ) from four different institutions were histopathologically compared with Wnt pathway tumors [ transgenes Wnt 1 , Wnt10b , dominant negative glycogen synthase kinase 3 beta , beta Catenin , and spontaneous mutants of adenomatous polyposis coli gene ( Apc ) ] . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| Abnormal expression of E cadherin , beta catenin , and c erbB 2 in advanced gastric cancer : its association with liver metastasis . ^^^ BACKGROUND AND AIMS : We investigated expression of E cadherin , beta catenin , and c erbB 2 in gastric cancer to identify molecular factor ( s ) relevant to development of liver metastasis , which is a frequent cause of mortality in gastric cancer patients . ^^^ PATIENTS AND METHODS : We analyzed by immunohistochemistry and compared expression patterns of E cadherin , beta catenin , and c erbB 2 in the tumor between 40 cases of gastric cancer ( GC ) without ( GC H ( ) ) and 16 with concurrent liver metastasis ( GC H ( + ) ) . ^^^ |
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| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| To clarify the clinical significance of TSG expression in gastric carcinoma , the expression of various TSG candidates ( p 53 , E cadherin , FHIT , smad 4 , rb , VHL , PTEN , MGMT , p 16 , and KAI 1 ) , as well as other proteins ( bcl 2 , MUC 1 , MUC 2 , MUC5AC , MUC 6 , CEA , CD 44 , beta catenin , C erbB 2 , and cyclin B 2 ) , was evaluated immunohistochemically in 329 consecutive gastric carcinomas using the tissue array method . ^^^ |
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| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| A literature search was undertaken using PubMed and MEDLINE search engines , using the keywords p 53 , p 21 , p 16 , p 27 , SMAD 4 , K ras , cyclin D 1 , Bax , Bcl 2 , EGFR , EGF , c erbB 2 , HB EGF , TGFbeta , FGF , MMP , uPA , cathepsin , heparanase , E cadherin , laminins , integrins , TMSF , CD 44 , cytokines , angiogenesis , VEGF , IL 8 , beta catenin , DNA microarray , and gene profiling . ^^^ |
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| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| A subset of high grade pulmonary neuroendocrine carcinomas shows up regulation of matrix metalloproteinase 7 associated with nuclear beta catenin immunoreactivity , independent of EGFR and HER 2 gene amplification or expression . ^^^ Less is known on beta catenin transactivation in high grade pulmonary neuroendocrine tumors and on the status of beta catenin activating EGFR and human epidermal growth factor receptor 2 ( HER 2 ) or beta catenin target genes cyclin D 1 and matrix metalloproteinase 7 ( MMP 7 ) . beta catenin immunoreactivity was evaluated in 51 large cell neuroendocrine carcinomas ( LCNEC ) and 45 small cell lung carcinomas ( SCLC ) . ^^^ Nineteen cases were assessed for beta catenin gene exon 3 mutations , expression of MMP 7 , and expression / gene amplification of EGFR , HER 2 , and cyclin D 1 . beta catenin was expressed in all 96 high grade neuroendocrine tumors , the vast majority ( 94 % ) showing > 50 % immunopositive cells . ^^^ In LCNEC , but not in SCLC , the disarrayed patterns correlated with EGFR and HER 2 protein expression . beta catenin nuclear accumulation was found in nine tumors , including seven LCNEC and two SCLC , and was always associated with disarrayed immunoreactivity and increased MMP 7 , but not cyclin D 1 expression . ^^^ These cases , however , did not show beta catenin gene mutations or EGFR and HER 2 gene amplification or expression . ^^^ |
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| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| We examined that fascin down expression also led to a decrease of c erbB 2 and beta catenin at the protein level . ^^^ |
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| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| FAT , E cadherin , beta catenin , HER 2 / neu , Ki 67 immuno expression , and histological grade in intrahepatic cholangiocarcinoma . ^^^ METHODS : Thirty one cases of IHCC were graded and immunostained for FAT , Ki 67 , E cadherin , beta catenin , and HER 2 / neu . ^^^ Strong membranous staining of HER 2 / neu was found in 10 tumours and reduced membranous E cadherin and beta catenin in 19 and 18 tumours , respectively . ^^^ Upregulation of HER 2 / neu was also significantly associated with nuclear localisation of beta catenin ( p=0 . 01 ) . ^^^ CONCLUSIONS : Reduced immuno expression of E cadherin and FAT at their normal membranous location may be potential prognostic markers , and the overexpression of HER 2 / neu and beta catenin nuclear translocation may have a role in cholangiocarcinogenesis . . ^^^ |
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| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| Using a tissue microarray , caveolin 1 expression was also correlated with the expression of other antigens such as eostrogen receptor , progesterone receptor , epidermal growth factor receptor ( EGFR ) , HER 2 , beta catenin , E cadherin , p 53 , Ki 67 and with clinicopathological parameters . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry was applied on 141 paraffin embedded breast tissue specimens for the detection of phospho beta catenin , ER , PR , c erbB 2 , p 53 , Ki 67 , bcl 2 , uPAR and TIMP 1 . ^^^ Cytoplasmic phospho beta catenin was statistically higher in carcinomas of smaller tumor size ( P = 0 . 030 ) , lower stage ( P = 0 . 026 ) , decreased Ki 67 and high c erbB 2 immunoreactivity ( P = 0 . 052 and P = 0 . 037 , respectively ) . ^^^ |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|