| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| Analysis of biochemical pathways implicated in signal transduction by growth factor receptors indicated that both phospholipase C type gamma ( PLC gamma ) and the p21ras GTPase activating protein ( GAP ) are substrates for the erbB 2 kinase in NIH 3T3 fibroblasts . ^^^ However , under conditions in which activation of the erbB 2 kinase induced DNA synthesis at least fivefold more efficiently than the EGFR , the levels of erbB 2 or EGFR induced tyrosine phosphorylation of PLC gamma and GAP were comparable . ^^^ Thus , our results indicate that differences in tyrosine phosphorylation of PLC gamma and GAP do not account for the differences in mitogenic activity of the erbB 2 kinase compared with either the EGFR or platelet derived growth factor receptor in NIH 3T3 fibroblasts . . ^^^ |
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| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| The hypothesis is supported by the fact that many cancer cells have some dysfunction in gap junctional intercellular communication , many tumor promoting chemicals and several oncogenes ( i . e . , ras , src , mos , neu , but not myc ) reduce gap junctional intercellular communication , and several growth factors ( i . e . , EGF , TGF beta , bovine pituitary extract ) inhibit gap junction function . ^^^ |
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| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| Inhibition of gap junctional intercellular communication and malignant transformation of rat liver epithelial cells by neu oncogene . ^^^ A retrovirus containing a neu oncogene was introduced into a Fischer F 344 rat liver epithelial cell line ( WB F 344 ) to study the effect of the expression of neu oncoprotein on gap junctional intercellular communication ( GJIC ) , the ability to form colonies in soft agar and the ability to form tumors in rat liver by these cells . ^^^ |
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| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| The expression of Cx 43 gap junctions was compared to the levels of estrogen , progesterone , and erbB 2 tyrosine kinase receptors . ^^^ Cx 43 gap junctions were not observed in ductal carcinomas in situ , infiltrating ductal carcinomas , and infiltrating lobular carcinomas , and they seem to be independent of estrogen , progesterone , and erbB 2 receptor status . ^^^ |
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| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| Cytosol from EGF treated A 431 human epidermoid carcinoma cells was used as a source of PTPase activity , and tyrosine phosphorylated ErbB 2 , EGF receptor , phospholipase C gamma 1 , and the Ras GTPase activating protein were used as substrates to monitor PTPase activity . ^^^ EGF stimulated PTPase activity that was selective toward these substrates , as it dephosphorylated ErbB 2 and the EGF receptor , but not phospholipase C gamma 1 and the Ras GTPase activating protein . ^^^ |
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| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| PLC gamma , ras GAP and Shc have been proposed to be in vivo substrates for the neu encoded p185neu receptor tyrosine kinases . ^^^ We compared the tyrosine phosphorylation levels of PLC gamma , ras GAP and Shc in two NIH3T3 derived cell lines , transformed B 104 1 1 and non transformed DHFR / G8 cells in which point mutation activated and normal rat neu genes were transfected and expressed , respectively . ^^^ |
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| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| Analyses of the members of the HRG stimulated complex revealed that RAFTK is associated with p 190 RhoGAP ( p 190 ) , RasGAP and ErbB 2 , and plays an essential role in mediating the tyrosine phosphorylation of p 190 by Src . ^^^ |
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| Interacting proteins: P20936 and P04626 |
Pubmed |
SVM Score :0.0 |
| In three of four tumors examined with activated wild type p21ras , we observed increased c erbB 2 receptor expression and decreased Ras GAP expression . ^^^ |
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