| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| All carcinomas in which tyrosine phosphorylated PLC gamma 1 was present also expressed detectable levels of the epidermal growth factor receptor or erbB 2 , two tyrosine kinases known to phosphorylate this enzyme . ^^^ |
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| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| Cytosol from EGF treated A 431 human epidermoid carcinoma cells was used as a source of PTPase activity , and tyrosine phosphorylated ErbB 2 , EGF receptor , phospholipase C gamma 1 , and the Ras GTPase activating protein were used as substrates to monitor PTPase activity . ^^^ EGF stimulated PTPase activity that was selective toward these substrates , as it dephosphorylated ErbB 2 and the EGF receptor , but not phospholipase C gamma 1 and the Ras GTPase activating protein . ^^^ |
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| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| Other tyrosine kinases such as the platelet derived growth factor receptor and erbB 2 , but not the insulin receptor , also stimulated PLC gamma 1 activity . ^^^ |
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| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| METHOD : We report the effects of two novel HER 2 binding affibody molecules ( Affibody ) , ( ZHER 2 : 4 ) 2 and ZHER 2 : 342 , on intracellular signal transduction pathways ( Erk1 / 2 , Akt and PLCgamma 1 ) using quantitative immunoblotting techniques and their biological effects in cell culture . ^^^ |
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| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| We also determined whether there was any correlation between prognostic factors ( numbers of metastatic axillary nodes , histologic grade , c erbB 2 , p 53 , and E cadherin ) and the overexpression of PLC gamma 1 protein . ^^^ |
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| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| In contrast , c erbB 2 / EGFR expressing cells displayed baseline transient calcium oscillations after EGF treatment due to short term PLC gamma 1 tyrosine phosphorylation and short term IP 3 and DAG turnover . ^^^ A third cell line expressing a point mutated c erbB 2 receptor that lacks the autophosphorylation Y 1248 was generated to investigate whether the different PLC gamma 1 activation was attributed to this structure . ^^^ Neither PLC gamma 1 tyrosine phosphorylation nor IP 3 and DAG turnover and calcium oscillations were observed in this cell line , indicating the modulation of the PLC g 1 activation time course by c erbB 2 signaling . ^^^ In summary , c erbB 2 up regulation switches on the cell migration program by modulating the time course of PLC gamma 1 activation . . ^^^ |
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| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04626 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|