| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :1.4269166 |
| Here , we demonstrate that MUC 1 associates constitutively with ErbB 2 in human breast cancer cells and that treatment with heregulin / neuregulin 1 ( HRG ) increases the formation of MUC 1 ErbB2 complexes . 1.4269166^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| The occurrence of epithelial membrane antigen ( EMA ) , low molecular weight cytokeratin ( CK ) and erbB 2 oncoprotein was investigated in twenty eight cases of Paget ' s disease of the nipple ( PD ) to determine their diagnostic usefulness . ^^^ Immunoreactivity for CK and erbB 2 oncoprotein was restricted to the Paget ' s cells , whereas EMA in some cases also stained the adjacent keratinocytes . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| For immunostaining , antibodies reacting with epithelial membrane antigen ( EMA ) , pankeratin , vimentin , CA 125 , CA 19 9 , carcinoembryonic antigen ( CEA ) , alpha fetoprotein ( AFP ) , alpha 1 antitrypsin ( AT ) , epidermal growth factor receptor ( EGFR ) , c erbB 2 , bcl 2 and p 53 proteins were used . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical staining showed nuclear immunoreactivity for c myc and cytoplasmic staining for CEA , EMA , CAM 5 . 2 , EGRF , c erbB 2 and pan cytokeratin in all the Paget cells . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical study showed that Paget cells were EMA and c erbB 2 positive in 100 % and 84 % , respectively . ^^^ Four of the six EMA positive and c erbB 2 negative cases of Paget ' s disease of the nipple in which the underlying tumor could be pathologically analyzed were associated with ductal carcinoma in situ of cribriform or mixed types . ^^^ These findings are helpful for differentiating Paget ' s disease from other lesions of the nipple , namely Bowen ' s disease and eczema which do not react with both antibodies , and from nipple adenoma which exhibits a positive staining with anti EMA antibody and no reactivity with anti c erbB 2 antibody . . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| The growth fraction ( MIB 1 ) , oestrogen receptor ( ER ) , progesterone receptor ( PR ) , p 53 mutant protein , c erbB 2 , epidermal growth factor receptor ( EGFR ) , NCRC11 / epithelial membrane antigen ( EMA ) and DNA plopidy were examined . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| The immunohistochemistry analysis was carried out evaluating in all cases : low and high cytoqueratines ( AE 1 , AE 3 ) , membrane epithelial antigen ( EMA ) , vimentin , carcinoembrionary antigen ( CEA ) , proliferative cell nuclear antigen ( PCNA ) and the oncoproteins p 53 and focal c erbB 2 . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry using the avidin biotin technique was applied for the expression of the markers p 53 ( D 07 ) , carcinoembryonic antigen ( CEA ) , c erbB 2 , epithelial membrane antigen ( EMA ) , and alpha fetoprotein ( AFP ) . ^^^ The tumour cells expressed p 53 , CEA , and EMA immunoreactivity and were negative for c erbB 2 and AFP . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| The cells were positive for cytokeratins ( AE1 / AE3 and CK 7 ) , EMA and c erbB 2 . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical co expression of c erbb 2 / Neu oncoprotein , altered tumour suppressor ( p 53 ) protein , EGF R and EMA in histological subtypes of infiltrating duct carcinoma of the breast . ^^^ Immunohistochemical staining of c erbB 2 ( Neu ) oncoprotein and mutant p 53 protein on 45 cases of infiltrating duct carcinoma ( IDC ) of the breast revealed 33 % membrane positivity of c erbB 2 oncoprotein , 46 % nuclear positivity of mutated p 53 protein , 33 % and 84 % membrane positivity of EGF R and EMA respectively . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemically , epithelial elements stained as follows : cytokeratin ( AE1 / AE3 & CAM 5 . 2 ) positive in 3 of 3 cases , EMA positive in 3 of 3 cases , vimentin negative in 3 of 3 cases , desmin negative in 3 of 3 cases , c erbB 2 positive in 1 of 2 cases . ^^^ Sarcomatoid elements stained as follows : AE1 / AE3 negative in 3 of 3 cases , CAM 5 . 2 rare positive cell in 1 of 3 cases , EMA focally positive in 3 of 3 cases , vimentin positive in 3 of 3 cases , desmin negative in 3 of 3 cases , c erbB 2 negative in 2 of 2 cases . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| In addition , each sample was analyzed immunohistochemically with proliferating cell nuclear antigen ( PCNA ) , p 53 , c erbB 2 , CEA and EMA antibodies . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| METHODS : In addition to routine staining immunohistochemical stains for CK ( AE1 / AE3 ) , CK 7 , CK 20 , EMA , alpha smooth muscle ( SM ) actin , S 100 protein , CD 34 , P 53 , Bcl 2 , c erbB 2 were performed . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| All cases were stained with hematoxylin and eosin ( H & E ) , Alcian blue pH 2 . 5 and periodic acid Schiff ( PAS ) preceded by diastase digestion and with immunohistochemistry using antisera anti cytokeratin 7 , cytokeratin 20 , protein S 100 , GCDFP 15 , c Erb B 2 , CAM 5 . 2 , and epithelial membrane antigen ( EMA ) . ^^^ The immunocytochemical profile of the cancer cells was similar to that of TC , but in addition the neoplastic cells were c Erb B 2 and EMA positive in all cases , and one case also displayed numerous cells immunoreactive with anti GCDFP 15 antibody . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| They expressed vimentin , HNK 1 , HBA 71 , Ki 67 , cyclin D 1 , Fli 1 , S 100 , p 21 , p 27 , and p 53 and were negative for cytokeratin , EMA , p 14 , p 16 , MDM 2 , Rb , and c erb b 2 antigens . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| They were variably positive for vimentin and negative for epithelial membrane antigen ( EMA ) , steroid receptors , p 53 , and HER 2 / neu . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry revealed that the sarcomatous cells were positive for alpha smooth muscle actin ( alpha SMA ) , vimentin , calponin , S 100 protein , epithelial membranous antigen ( EMA ) , cytokeratin ( large spectrum ) and cytokeratin 14 ( CK 14 ) in the cytoplasm , and p 53 , erbB 2 and progesterone receptor in the nuclei , but negative for desmin and estrogen receptor . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Tissue blocks were reviewed and sections containing both carcinomatous and sarcomatous elements were stained for epithelial membrane antigen ( EMA ) , vimentin , vascular endothelial growth factor ( VEGF ) , CD45RO , c erbB 2 , p 53 , CD 34 , Ki 67 , S 100 , estrogen , and progesterone receptors . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical studies for AE1 / AE3 , CEA , EMA , CK 7 , 34betaE12 , NSE , synaptophysin , chromogranin A , Leu 7 , vimentin , S 100 , SMA , calponin , estrogen receptor , progesterone receptor , c erbB 2 , E cadherin , Ki 67 and p 53 were also carried out . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| High expression of the cell surface molecules c ErbB 2 and episialin make it a potentially useful model for research in immune therapy . . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| MUC 1 ( episialin ) expression in non small cell lung cancer is independent of EGFR and c erbB 2 expression and correlates with poor survival in node positive patients . ^^^ AIM : To examine tumour samples immunohistochemically for MUC 1 ( episialin ) , epidermal growth factor receptor ( EGFR ) , and c erbB 2 , since the disruption of the cell cell adhesion system by MUC 1 and the c erbB oncoprotein family is known to be important in the development of metastasis in human cancers . ^^^ METHODS : 93 tumour samples from patients with early stage non small cell lung cancer treated with surgery alone were examined for episialin , EGFR , and c erbB 2 . ^^^ No correlation was observed between episialin and EGFR or c erbB 2 expression . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| For this purpose , the expression of HLA class 1 antigen and TAP 1 molecule ( a transporter in the antigen processing 1 transport protein ) were studied with epidermal growth factor , receptor ; c erbB 2 ; episialin ; wild type and mutant p 53 ; bcl 2 oncoprotein expression ; and angiogenic factor expression ( vascular endothelial growth factor and thymidine phosphorylase ) . ^^^ A strong association of c erbB 2 and MUC 1 ( episialin ) expression with HLA class 1 expression was observed ( p = 0 . 005 and 0 . 009 , respectively ) . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| The authors examined several loci ( ERBB 2 , INT 2 , MUC 1 ) for gene amplification or loss of heterozygosity by Southern blotting and for gene expression by immunohistochemistry in breast tumors from patient groups selected by survival . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Though no point mutation at 12 codon of K ras was detected , expression of c erb B 2 product and MUC 1 antigen was positive . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Use of transcriptional regulatory elements of the MUC 1 and ERBB 2 genes to drive tumour selective expression of a prodrug activating enzyme . ^^^ In order to exploit differences in gene expression between normal and malignant cells for genetic prodrug activation therapy , we have generated recombinant retroviruses containing the herpes simplex virus thymidine kinase coding region cloned downstream of sequences derived from the 5 ' flanking regions of the MUC 1 and ERBB 2 genes . ^^^ These results suggest that one may be able to develop a tumour selective therapy by utilizing the transcriptional regulatory regions of the MUC 1 and ERBB 2 genes to drive the expression of suicide genes . . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Using flow cytometry , the expression of HLA 1 , ERBB 2 and MUC 1 was found to be comparable in ' normal ' MCF 10F , transformed BP 1 and tumorigenic BP 1 Tras cells . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| The relative expression of mucin antigens MUC 1 , MUC 2 , MUC 3 , MUC 4 , MUC5AC , MUC5B , and MUC 7 and glycoprotein antigens KSA , carcinoembryonic antigen , prostate specific membrane antigen ( PSMA ) , HER 2 / neu , and human chorionic gonadotropin beta on different cancers and normal tissues is difficult to determine from available reports . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| To evaluate the antigen profile of disseminated cells found in BM aspirates from 20 breast cancer patients , we applied a quantitative immuno cytochemical double marker assay and typed for 4 common tumor associated cell surface antigens ( c erbB 2 , CO 17 1A , MUC 1 , LewisY ) . ^^^ CK+ cells co expressed c erbB 2 , CO 17 1A , MUC 1 and LewisY in 87 % , 78 % , 79 % and 79 % of patients , respectively ; however , the frequency of double positive cells per sample varied considerably . ^^^ The mean percentage of double positive cells per total number of CK+ cells was 41 % for c erbB 2 ( range 0 92 % ) , 47 % for CO 17 1A ( range 0 75 % ) , 49 % for MUC 1 ( range 0 67 % ) and 32 % for LewisY ( range 0 59 % ) . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| In breast cancer , these molecular targets have included principally tumor associated antigens , such as carcinoembryonic antigen ( CEA ) and the polymorphic epithelial mucin antigen , MUC 1 , and more recently the growth factor receptors , EGF R and HER 2 / neu . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| This review focuses on the next step of using tissue specific promoters such as Muc 1 , CEA , PSA , HER 2 , Myc , L plastin and secretory leukoproteinase inhibitor promoters . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| CMI and humoral immune reactivity have been demonstrated to autologous tumor and a variety of tumor associated antigens ( TAA ) have been implicated including CEA , HER 2 / neu , MAGE 1 , p 53 , T / Tn and MUC 1 . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Cell surface expression of the following was examined : EGP 2 ; MUC 1 ; EGFr ; E and N cadherin ; the alpha 2 , alpha 3 , alpha 5 , beta 1 and beta 4 integrins ; c erb B 2 ; and N CAM . c erb B 2 was expressed in a higher percentage of the bone metastasizing MT 1 cells than the MA 11 cells , whereas E cadherin was expressed in MA 11 but not MT 1 cells . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| In addition to finding the predicted overexpression of known breast cancer markers HER 2 / neu and MUC 1 , the powerful coupling of SAGE and DNA arrays resulted in the identification of genes and potential pathways not implicated previously in breast cancer . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Tumor associated antigens , such as MAGE antigens , SART antigens , MUC 1 antigen , c erbB 2 antigen or cancer / testis antigens can be served to target antigens for BsAb production . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Cytotoxicity assays utilizing T 2 cells loaded with peptides as target cells indicated that none of the examined CTL epitopes derived from HER 2 / neu , Muc 1 , Ep CAM 1 , and p 53 were recognized by the CTL clones generated . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| In this immunohistochemical study we analysed the expression of three tumor antigens , p 53 , HER 2 / neu and MUC 1 in relation to the expression of major histocompatibility complex ( MHC ) class 1 and 2 on tumor cells , and we searched for the presence of ( activated ) immune effector cells at the tumor site . ^^^ HER 2 / neu and MUC 1 staining was positive in 8 / 29 ( 28 % ) and 21 / 28 ( 75 % ) , respectively . ^^^ CONCLUSIONS : As only three out of 29 patients were negative for the tumor antigens p 53 , HER 2 / neu and MUC 1 , immunotherapy aiming at all three could serve almost all patients with ovarian cancer . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| To assess the utility of this technology in breast cancer staging , we determined the relative expression levels of 12 cancer associated genes ( mam , PIP , mamB , CEA , CK 19 , VEGF , erbB 2 , muc 1 , c myc , p 97 , vim and Ki 67 ) in 51 negative control normal lymph nodes and in 17 histopathology positive ALNs . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| A direct association of CA 9 expression with epidermal growth factor receptor , c erbB 2 , and MUC 1 expression was also noted ( P < 0 . 04 ) . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Pro oncogenic factors that also release beta catenin from the adherens complex and / or encourage translocation to the nucleus include ras , epidermal growth factor ( EGF ) , c erbB 2 , PKC betaII , MUC 1 , and PPAR gamma , whereas anti oncogenic factors that also inhibit nuclear beta catenin signaling include transforming growth factor ( TGF ) beta , retinoic acid , and vitamin D . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| These include MUC 1 , Thomsen Friedenreich and Sialosyl Tn antigens and HER 2 / neu . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Breast cancer vaccines include Theratope , MUC 1 mucin peptides and HER 2 / neu peptide vaccines . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| We provide evidence that patients with advanced breast and ovarian cancer can be efficiently vaccinated with autologous DC pulsed with HER 2 / neu or MUC 1 derived peptides . ^^^ In a second patient immunized with the HER 2 / neu peptides , MUC 1 specific T lymphocytes were induced after seven immunizations , suggesting that antigen spreading in vivo might occur after successful immunization with a single tumor antigen . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Eight of 24 patients made an antibody response to HER 2 / neu , four of 24 to MUC 1 and one of 24 to p 53 . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| To clarify the clinical significance of TSG expression in gastric carcinoma , the expression of various TSG candidates ( p 53 , E cadherin , FHIT , smad 4 , rb , VHL , PTEN , MGMT , p 16 , and KAI 1 ) , as well as other proteins ( bcl 2 , MUC 1 , MUC 2 , MUC5AC , MUC 6 , CEA , CD 44 , beta catenin , C erbB 2 , and cyclin B 2 ) , was evaluated immunohistochemically in 329 consecutive gastric carcinomas using the tissue array method . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Interestingly , these polyclonal cytotoxic T cells recognized selectively two epitopes derived from the MUC 1 and Her 2 / neu tumor Ags . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Besides the well known over expression of HER 2 / neu , CEA , and MUC 1 , multiple antigens of the MAGE family were frequently co expressed . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : Breast cancers are known to frequently ( over ) express several well characterized tumor associated antigens ( TAAs ) such as carcinoembryonic antigen , MUC 1 , Her 2 / neu , and cancer / testis antigens such as NY ESO 1 , SSX 2 , and members of the MAGE family . ^^^ EXPERIMENTAL DESIGN : Using MUC 1 and Her 2 / neu derived HLA A * 0201 restricted peptides as model antigens , we analyzed antigen dependent IFN gamma release of T cells by enzyme linked immunospot ( ELISpot ) assay , intracellular cytokine flow cytometry ( CytoSpot ) , and quantitative real time PCR . ^^^ By doing this , we detected in 7 of 13 ( 54 % ) of HLA A * 0201 ( + ) breast cancer patients a pre existent specific cellular immune response to at least one of the investigated TAAs ( MUC 1 , Her 2 / neu , carcinoembryonic antigen , NY ESO 1 , and SSX 2 ) . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| We found that transient transfection of activated ErbB 2 into human embryonic kidney 293 / MUC1 cells resulted in the repression of MUC 1 expression . ^^^ Further , transient transfection of activated ErbB 2 resulted in the inhibition of Muc 1 transcriptional activation in luciferase reporter assays . ^^^ These data suggest that the activation of ErbB 2 , which only occurs in c Neu tumors , selectively inhibits Muc 1 expression . . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| We also describe the recent development and validation of the most studied mucins ( MUC 1 and MUC 16 ) , ErbB 2 ( Her2 / neu ) and folate binding protein as target based immunotherapy of ovarian cancer . . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Tissue microarrays ( TMAs ) were used to determine the immunohistochemical profile of eight proteins including E cadherin , EGFR , oestrogen and progesterone receptor ( ER and PR ) , MIB 1 , ERBB 2 , MUC 1 , and P 53 . ^^^ The five variables that were significantly associated with IBC in multivariate analysis were E cadherin > or = 300 [ HR = 5 . 64 ( 2 . 92 10 . 87 ) ] , ER negative [ HR = 3 . 00 ( 1 . 67 5 . 51 ) ] , MIB 1 > 20 [ HR = 3 . 54 ( 1 . 87 6 . 71 ) ] , MUC 1 cytoplasmic staining [ HR = 2 . 72 ( 1 . 49 4 . 96 ) ] , and ERBB 2 positive 2+ or 3+ [ HR = 2 . 46 ( 1 . 26 4 . 78 ) ] . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Standard immunohistochemistry was performed with antigenic retrieval using different monoclonal antibodies ( MAbs ) : anti carbohydrate antigens : Lewis 10 ( KM 380 ) , sLewis 10 ( KM 93 ) , Lewis y ( C 14 ) and Tn , anti MUC 1 peptide core MAbs : C 595 , HMFG 2 and SM 3 , anti cytokeratins , anti protoncogenes ErbB 2 and ErbB 3 ( IgG ) MAbs and also anti CD 34 and anti CD 45 MAbs . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| We analyzed MART 1 , S 100 , MBP , and CD 63 for melanoma and p 53 , MUC 1 , cyclin B 1 , HER 2 / neu , and CEA for breast cancer . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| We examined the growth characteristics and colony forming ability of the established cell lines in terms of their cell cycle parameters and expression of tumor markers ( CEA , CA 19 9 , MUC 1 and c kit ) and oncogene ( c erbB 2 ) by flow cytometry . ^^^ Two cell lines formed colonies in the colony forming assays ; all three cell lines expressed CEA , CA 19 9 , MUC 1 and c erbB 2 and showed chromosomal aneuploidy . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Moreover , an emphasis is placed on the importance of critical signaling pathways and postulated interactions , including those of ErbB 2 , hepatocyte growth factor / Met , interleukin 6 / glycoprotein130 , cyclooxygenase 2 , vascular endothelial growth factor , transforming growth factor beta , MUC 1 and MUC 4 , beta catenin , telomerase , and Fas pathways as potential molecular therapeutic targets in cholangiocarcinoma . . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| Two additional groups were characterized by high c erbB 2 positivity and negative or weak hormone receptors expression but showed differences in MUC 1 and E cadherin expression . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| The vectors PAI 2 , C 595 and Herceptin target the membrane bound uPA , MUC 1 and HER 2 antigens expressed by cancer cells , respectively . ^^^ The expression of these receptors was tested in the ovarian cancer cell line OVCAR 3 ; MUC 1 was strongly expressed ( 3+ ) , uPA moderately expressed ( 2+ ) , but HER 2 was negative ( ) . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| METHODS : The expression profiles of MUC 4 , ErbB 2 , p 27 , and MUC 1 were investigated in IDC tissues from 135 patients by means of immunohistochemistry . ^^^ ErbB 2 , p 27 , and MUC 1 were not independent risk factors . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| The patients received either Muc 1 , CEA , gpl 00 , Her 2 or SART 3 PDAK cells generated in vitro , intravenously in combination with 350 , 000 U IL 2 weekly for 9 weeks , together with a planned dose escalation schedule of three transfers each of 1 10 10 ( 7 ) , 3 10 10 ( 7 ) and 1 10 10 ( 8 ) PDAK cells / kg for 6 patients , and with a uniform dose of 3 10 10 ( 7 ) PDAK cells / kg for the remaining 5 patients . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| These alterations can be categorized as `` early ' ' such as k ras mutation , HER 2 / neu , PSCA , MUC 5 , and fascin overexpression ; `` intermediate ' ' such as p 16 inactivation , MUC 1 , and cyclin D 1 overexpression ; and finally as `` late ' ' such as p 53 and DPC 4 inactivation , BRCA 2 mutation , and overexpression of ki 67 , 14 3 3sigma , and mesothelin . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| In order to enhance their immunogenicity , ovarian tumor cells ( SK OV 3 , which express two well characterized antigens HER 2 / neu and MUC 1 ) were killed by oxidation with hypochlorous acid ( HOCl ) . ^^^ In ELISPOT assays , T cells produced interferon gamma ( IFN gamma ) in response to the immunizing cellular antigen , and also to peptides coding for MUC 1 and HER 2 / neu HLA A 2 restricted epitopes , demonstrating efficient cross presentation of cell associated antigens . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| To further characterize these systems , immunocytochemical analysis was performed for differentiation antigens ( PEM 200 kDa , CEA , NCA 90 kDa ) , blood group related antigens ( Le ( 10 ) , sTn ) , oncogenes and tumor suppressor gene products ( Her 2 / neu protein , p 53 ) , metastasis related cathepsin D and CD63 / 5 . 01 Ag , and the chemokine monocyte chemotactic protein 1 ( MCP 1 ) . ^^^ |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|