| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.86301514 |
| Despite the extensive similarity between the c erbB 2 protein and EGF receptor , neither EGF nor TGF alpha bound to the c erbB 2 protein . 0.86301514^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| We conclude that this TGF alpha like ( gp 30 ) polypeptide is a novel growth factor with agonistic activity for both EGF and erbB 2 receptors . . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Overexpression of many growth factors / receptors , such as EGF , TGF alpha , EGF receptor and ERBB 2 , and reduction of type 1 receptor for TGF beta may be linked with new prognostic factors of gastric carcinomas . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The specificity of the elevated transcription of TGF alpha , TGF beta , bFGF and flg in glioblastoma cell lines is further suggested by the fact that the transcription of the proto oncogene c erbB 2 , which is overproduced in breast tumor cell lines , was not elevated in glioblastoma cell lines . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical studies on oncogene products ( EGF R , c erbB 2 ) and growth factors ( EGF , TGF alpha ) in human breast cancer : their relationship to oestrogen receptor status , histological grade , mitotic index and nodal status . ^^^ In this investigation , 83 human mammary carcinomas were examined for the expression of oestrogen receptor ( ER ) , epidermal growth factor receptor ( EGF R ) , epidermal growth factor ( EGF ) , transforming growth factor alpha ( TGF alpha ) , c erbB 2 , histological grade , mitotic index and nodal status , all of which are reportedly prognostically significant factors ( Bloom and Richardson 1957 ; Baak et al . 1985 ; Wright et al . 1989 ) . ^^^ ER expression was biochemically recognized in 43 . 4 % of mammary carcinomas , and EGF R , EGF , TGF alpha and c erbB 2 were histochemically recognized in 25 . 3 , 14 . 5 , 27 . 7 and 18 . 0 % of mammary carcinomas examined respectively , using conventional sections of buffered formalin fixed , paraffin embedded tissue and monoclonal or polyclonal antibodies . ^^^ There were significant relationships between negative ER and positive EGF R or TGF alpha ; positive EGF R and TGF alpha ; positive EGF R and c erbB 2 ; and positive c erbB 2 and TGF alpha . ^^^ Therefore , the present investigation indicates that the negative ER , single expression of c erbB 2 and co expression of EGF R and TGF alpha are important markers which contribute indirectly to prognosis , which reconfirms previous findings on the former two while adding the new finding that immunohistochemical demonstration of expression of EGF R and TGF alpha may provide useful information for selecting the appropriate treatment . . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| All three cell lines expressed transforming growth factor alpha ( TGF alpha ) , epidermal growth factor receptor ( EGFR ) , c erb B 2 , and c met genes . ^^^ RVH 6849 cells , however , expressed the most messenger RNA ( mRNA ) for TGF alpha , c erb B 2 , and c met . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| We have previously shown that overexpression of a human point mutated c Ha ras proto oncogene , the rat c neu ( c erbB 2 ) proto oncogene , or the human transforming growth factor alpha ( TGF alpha ) gene in MCF 10A cells leads to in vitro transformation of such cells . ^^^ To ascertain whether the introduction of two of these genes into MCF 10A human mammary epithelial cells induces a completely tumorigenic phenotype , we infected MCF 10A Ha ras and MCF 10A TGF alpha cells with a recombinant retroviral vector containing the human c erbB 2 proto oncogene and the hygromycin resistance gene . ^^^ Ten MCF 10A TGF alpha / c erbB 2 ( MCF 10A TE ) and 10 MCF 10A Ha ras / c erbB 2 ( MCF 10A HE ) hygromycin resistant clones were randomly selected and expanded into cell lines . ^^^ Moreover , both MCF 10A TE and MCF 10A HE clones exhibited a fivefold to 20 fold higher cloning efficiency in soft agar than MCF 10A Ha ras , MCF 10A c erbB 2 , or MCF 10A TGF alpha clones . ^^^ These results suggest that c Ha ras , c erbB 2 , and TGF alpha genes have an additive effect on the in vitro transformation of an immortalized human mammary epithelial cell line , but that additional genetic changes such as activation of other proto oncogenes or inactivation of a tumor suppressor gene may be necessary to elicit a fully tumorigenic phenotype . . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Several oncoproteins ( c myc , c Ha ras , c erbB 2 ) and growth factors / receptors ( EGF , EGF R , TGF alpha ) were immunostained . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Using MDP CM , the presence of a 25 kDa polypeptide distinct from EGF , PDGF , FGF , IGF , TGF alpha and TGF beta and TNF alpha , could be demonstrated by decorating a Western blot with soluble NEU and anti NEU antibodies . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| However , it is distinct from TGF alpha as determined by peptide mapping and its ability to induce activation of erbB 2 . ^^^ TGF alpha and EGF are incapable of directly inducing phosphorylation of erbB 2 . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Formalin fixed paraffin embedded tumor tissue from 51 node positive breast cancer patients were analyzed for the expression of neu , epidermal growth factor receptor ( EGF R ) , and transforming growth factor alpha ( TGF alpha ) using immunoperoxidase staining . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| There are abnormalities in the structure and / or function of several oncogenes and growth factors in human pancreatic cancer , notably the EGF receptor and its ligand TGF alpha , c erb B 2 proto oncogene , Ki ras oncogene and the tumour suppressor gene p 53 . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical demonstration of growth factors , TGF alpha , TGF beta , IGF 1 and neu oncogene product in benign and malignant human breast tissues . ^^^ The expression of growth factors , TGF alpha , TGF beta , IGF 1 and neu oncogene product was studied immunohistochemically in the tissue of 120 benign and malignant human breasts . ^^^ Carcinoma in situ and invasive breast carcinomas demonstrated a significantly higher percentage of stained cells than that observed in benign lesions ; forty ( 49 % ) of 82 invasive carcinomas were positive for TGF alpha , 31 ( 38 % ) for TGF beta , 31 ( 38 % ) for IGF 1 and 34 ( 41 % ) for neu product . ^^^ The concomitant expression of TGF alpha and neu oncogene product in cell surface was also observed . ^^^ However , TGF alpha , IGF 1 and neu overexpression showed no effect on the prognosis of the patients . . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| No amplifications were demonstrated for c Ha ras 1 , TGF alpha , c mos , c erbB 2 , or c erbA 2 . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| This is substantiated by the facts that EGF and TGF alpha act as autocrine growth factors and then induce the expression of mRNAs for multi growth factors and their receptors ( EGF , TGF alpha , EGFR , ERBB 2 , PDGF ) . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Both EGF and TGF alpha stimulated EGFR phosphorylation , EGF and TGF alpha induced FOS , MYC and ERBB 2 oncogene expression . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| EGF or TGF alpha induced tyrosine phosphorylation of the chimeric receptor protein , stimulated DNA synthesis of EGF R neu expressing cells and led to a transformed cell morphology and growth in soft agar . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| These effects were specific for ras because neu transformed NOG 8 cells grew in soft agar at a comparable level to NOG 8 SR 2 cells yet did not show any increase in TGF alpha production or change in EGF receptor expression . . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Using ELISAs , we determined the concentrations of transforming growth factor alpha ( TGF alpha ) , the extracellular domain of the erbB 2 receptor ( erbB 2 ECD ) , and mutant p 53 protein in stored serum samples of asbestosis patients with and without cancer and control subjects ( without asbestosis or cancer ) . ^^^ The percentage of individuals in these three groups with increased serum concentrations of TGF alpha , erbB 2 ECD , and mutant p 53 , respectively , were : asbestosis patients with cancer , 36 % , 16 % , 19 % ; asbestosis patients without cancer , 38 % , 19 % , 6 % ; control subjects , 0 % , 5 % , 10 % . ^^^ In several of the cancer cases , increased concentrations of TGF alpha , erbB 2 ECD , and mutant p 53 were also detected in the stored serum samples collected years before the clinical diagnosis of disease . . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Transforming growth factor alpha ( TGF alpha ) is a potent mitogenic factor which acts by binding to the epidermal growth factor ( EGF ) . c erbB 2 is a member of the EGF receptor family and is known to be associated with cellular growth and differentiation . ^^^ All nine cases positive for TGF alpha were also positive for both EGF receptor and c erbB 2 protein . ^^^ Immunohistochemical studies indicate the expression of TGF alpha , EGF receptor and c erbB 2 protein in BPH tissues . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| In selected experimental groups , gene expression was determined of transforming growth factor beta 1 ( TGF beta 1 ) , prothrombin , c erb B 2 , transforming growth factor alpha ( TGF alpha ) , human Cyclophilin ( CyP ) , and 28S ribosomal RNA . ^^^ Little or no increase in expression of TGF alpha or the hepatocyte specific prothrombin gene was detectable in the first 48 hours , whereas levels of the oncogene c erb B 2 that is associated with cholangiocarcinoma were expressed from 48 to 96 hours . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Transcripts coding for transcription factors ( RB , P 53 , FOS , MYC , MYB , ERBA , REL ) , growth factors ( FGF 1 , FGF 2 , INT 2 , TGFA , TGFB , PDGF , IGF 1 , IGF 2 ) , interleukins , ( IL 1 , IL 2 , IL 3 , IL 4 , IL 6 , TNF ) , growth factor receptors or cytosolic protein kinases ( RAF , PIM , FES , MET , SRC , ROS , TRK , KIT , CSFR , IGFR , PDGFR , EGFR , NEU ) were quantified in cultured human mammary fibroblasts from normal tissues , benign tumours , carcinomas and post radiation fibrosis lesions by slot blot autoradiography and image analysis . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Gene expression of growth factors including epidermal growth factor ( EGF ) , transforming growth factor alpha ( TGF alpha ) , epidermal growth factor receptor ( EGFR ) , oncogenes such as c myc , N ras , c erbB 2 and tumor suppressor gene P 53 were studied in 4 human lung cancer cell lines using Northern blot technique . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Primary and metastatic ovarian cystadenocarcinomas , carcinomas of low malignant potential ( borderline tumors ) , benign ovarian cystadenomas , and normal ovaries were compared for immunoperoxidase detection of the ligands epidermal growth factor ( EGF ) , transforming growth factor alpha ( TGF alpha ) , amphiregulin ( AR ) , cripto , and the receptors , epidermal growth factor receptor ( EGF R ) , and c erbB 2 . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| To identify and modulate molecular SEBs in intraepithelial neoplasia of the upper aerodigestive tract , we studied expression of the epidermal growth factor receptor ( EGFR ) , transforming growth factor alpha ( TGF alpha ) , and HER 2 / neu genes in oral leukoplakia before , during , and after treatment with 13 cis retinoic acid , a vitamin A derivative . ^^^ Pretreatment expression of EGFR , TGF alpha , and HER 2 / neu in leukoplakia was increased when compared to normal appearing mucosa . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Reduction of RI alpha subunit of cAMP dependent protein kinase expression induces growth inhibition of human mammary epithelial cells transformed by TGF alpha , c Ha ras , and c erbB 2 genes . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Gene expression of TGF alpha , TGF beta 1 and C erbB 2 oncogene in human pancreatic carcinoma cell lines ] . ^^^ In this study , gene expression of TGF alpha ( a ligand of EGF receptor ) , TGF beta 1 and c erbB 2 oncogene were studied . ^^^ The presence of TGF alpha and c erbB 2 in human pancreatic carcinoma cell lines further verifies the occurrence of an autocrine growth regulation of this cancer . . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical detection of TGF alpha , EGF R , c erbB 2 , c H ras , c myc , estrogen and progesterone in benign and malignant human breast lesions : a concomitant expression . ^^^ The expression of transforming growth factor alpha ( TGF alpha ) , epidermal growth factor receptor ( EGF R ) and oncogenes c erbB 2 , c H ras , c myc , as well as estrogen ( ER ) and progesterone ( PR ) receptors were studied immunohistochemically in the tissue of 21 benign and 58 malignant human breast lesions . ^^^ Twenty nine ( 50 % ) of 58 carcinomas were positive for EGF R and c erbB 2 product , 55 ( 94 . 8 % ) for c myc product , 9 ( 15 . 5 % ) for c H ras product and 17 ( 29 % ) for TGF alpha . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Abnormal expression of p 53 , transforming growth factor alpha ( TGF alpha ) , epidermal growth factor receptor ( EGFR ) , and c erbB 2 occurs in a variety of cancers and in some cases is associated with poor prognosis . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Expression of EGF , TGF alpha , EGFR and c erbB 2 genes and their gene products in human pancreatic carcinoma cell lines . ^^^ The expression of mRNA for epidermal growth factor ( EGF ) , transforming growth factor alpha ( TGF alpha ) , EGF receptor ( EGFR ) and c erbB 2 genes and the immunoreactivity to these gene products were examined in 3 newly established human pancreatic carcinoma cell lines and their corresponding in vivo tumor lines using the Northern blot technique and the immunohistochemical method . ^^^ All 3 cell lines expressed TGF alpha , EGFR and 2 of the 3 lines expressed EGF and c erbB 2 mRNAs . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| All other growth factors and their receptors examined ( TGF alpha , EGFR , c met and c erbB 2 ) remained constant and were not affected by HGF treatment . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The mRNA expression of transforming growth factor alpha ( TGF alpha ) , epidermal growth factor receptor ( EGFR ) , c erbB 2 and c met proto oncogenes in eight newly established cell lines and 29 primary tumors of human non small cell lung carcinoma ( NSCLC ) have been investigated . ^^^ In vitro , the expressions of TGF alpha , c erbB 2 , and c met were consistently high in adenocarcinomas , while EGFR was expressed highest in a squamous cell carcinoma cell line . ^^^ There was linear correlation between the levels of expression of TGF alpha and EGFR or c erbB 2 , and between EGFR and c erbB 2 . ^^^ The c met expression was also correlated with those of TGF alpha , EGFR , and c erbB 2 . ^^^ In vivo , The mean mRNA levels of TGF alpha , EGFR , and c met , but not c erbB 2 , were higher in carcinomas than in normal lung tissues ( 2 . 8 , 1 . 7 , and 3 . 0 times , respectively ) ; however , only adenocarcinomas expressed a significantly higher level of c erbB 2 than their corresponding normal tissues ( 2 . 2 times ) . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| We analyzed by immunohistochemistry 19 typical lung carcinoids for the expression of the epidermal growth factor ( EGF ) , transforming growth factor alpha ( TGF alpha ) , EGF receptor ( EGFr ) , and EGFr related c erbB 2 protein ( p 185 ) . ^^^ Thus , EGFr was coexpressed with its ligands , TGF alpha and EGF , and the receptor encoded by c erbB 2 was detected in carcinoids positive for EGFr and TGF alpha . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| We examined 190 fresh , frozen thyroid tissue samples from 70 patients by immunohistochemistry with antibodies to EGF r , TGF alpha , c erbB 2 and c myc . ^^^ EGF r expression was detected in 17 out of 19 papillary carcinomas , TGF alpha expression in 10 , and c erbB 2 expression in 15 . ^^^ Concomitant expression of EGF r , TGF alpha and c erbB 2 was seen in 7 papillary carcinomas . ^^^ No EGF r , TGF alpha or c erbB 2 immunopositivity was found in normal appearing thyroid tissue ( 25 cases ) , whereas a few of the non neoplastic lesions ( colloid goitres and diffuse hyperplasias ) expressed either EGF r or TGF alpha . c myc expression was detectable in all tissue samples , and expression was invariably nuclear . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The expression of mRNAs for epidermal growth factor ( EGF ) , transforming growth factor alpha ( TGF alpha ) , EGFR , platelet derived growth factor ( PDGF ) A and B chain , PDGF receptor ( PDGFR ) , transforming growth factor beta ( TGF beta ) , erbB 2 and estrogen receptor ( ER ) genes was first examined in 6 human esophageal carcinoma cell lines , 6 xenoplanted and 15 surgically resected esophageal carcinomas . ^^^ The expression of mRNAs for TGF alpha , PDGF A and B chain and the erbB 2 genes was also increased after treatment with EGF . ^^^ TGF alpha increased the accumulation of mRNAs for EGF , TGF alpha , EGFR , PDGF A and B chain and the erbB 2 gene . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The frequency of expression and localization of cripto 1 ( CR 1 ) , amphiregulin ( AR ) , transforming growth factor alpha ( TGF alpha ) , epidermal growth factor receptor ( EGFR ) and erbB 2 were examined by immunohistochemistry in 45 carcinomas and adjacent non involved normal colon mucosa . ^^^ Thirty ( 66 . 7 % ) , 24 ( 53 . 3 % ) , 23 ( 51 . 1 % ) , 23 ( 51 . 1 % ) and 13 ( 28 . 9 % ) of the 45 carcinomas showed positive staining for CR 1 , AR , TGF alpha , EGFR and erbB 2 , respectively , whereas 7 ( 15 . 5 % ) , 17 ( 37 . 7 % ) , 15 ( 33 . 3 % ) , 20 ( 44 . 4 % ) and 0 ( 0 % ) of the corresponding non involved normal mucosa specimens were reactive . ^^^ Among 13 carcinomas with lymph node involvement , 10 ( 76 . 9 % ) , 8 ( 61 . 5 % ) , 10 ( 76 . 9 % ) , 8 ( 61 . 5 % ) and 7 ( 53 . 8 % ) exhibited positive staining for CR 1 , AR , TGF alpha , EGFR and erbB 2 , respectively . ^^^ There was a statistically significant association between the frequency of either TGF alpha ( P < 0 . 05 ) or erbB 2 ( P < 0 . 05 ) expression and lymph node metastasis . ^^^ These data suggest that AR and TGF alpha may play an important role in the development of colorectal carcinomas through an autocrine mechanism involving EGFR , and demonstrate that TGF alpha and erbB 2 may be more reliable indicators of metastasis or prognosis than CR 1 , AR or EGFR in human colon cancers . . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The expression of growth factors , such as transforming growth factor alpha ( TGF alpha ) , amphiregulin ( AR ) and CRIPTO , a type 1 tyrosine kinase growth factor receptor ( erbB 2 ) , and a tumor suppressor gene ( p 53 ) , that have been implicated in the development and / or the progression of breast cancer , was evaluated by immunohistochemistry in 100 human primary infiltrating breast carcinomas ( IBC ) . ^^^ Within the 100 IBC , 80 , 50 , 73 , 17 , and 34 tumors expressed moderate to high levels of TGF alpha , AR , CRIPTO , erbB 2 , and p 53 respectively . ^^^ In contrast , only 4 , 3 , and 2 out of 10 normal mammary gland samples were weakly positive for TGF alpha , AR , and CRIPTO expression , respectively , whereas none was positive for erbB 2 or p 53 . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Analysis of EGFR , TGF alpha , neu and c myc in 2 amino 1 methyl 6 phenylimidazo [ 4 , 5 b ] pyridine induced mammary tumors using RT PCR . 2 Amino 1 methyl 6 phenylimidazo [ 4 , 5 b ] pyridine ( PhIP ) , a mutagen found in cooked meat , has been shown to induce mammary gland tumors in rats . ^^^ In the current study , reverse transcription followed by polymerase chain reaction amplification was used to determine whether EGFR , TGF alpha , neu and c myc are differentially expressed in PhIP induced mammary gland tumors classified histologically as benign or malignant and to evaluate whether dietary fat intake influences the expression of these genes . ^^^ Of 23 total PhIP induced mammary tumors examined , 43 % , 57 % and 74 % had increased expression of EGFR , TGF alpha and neu mRNA respectively . ^^^ The percentage of dietary fat did not appear to influence the expression of EGFR , TGF alpha or neu in either tumors or mammary gland from control rats . ^^^ These results suggest that increased expression of EGFR , TGF alpha and especially neu is associated with PhIP induced mammary gland cancer in rats . . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Of the 68 early colorectal carcinomas , EGF , TGF alpha , cripto , EGFR and c ERBB 2 products were detected at various degrees 24 ( 35 % ) , 50 ( 74 % ) , 31 ( 46 % ) , 11 ( 16 % ) , and 34 ( 50 % ) , respectively . ^^^ A significantly higher incidence ( P < 0 . 05 ) of expression of the following was noted ; TGF alpha in the polypoid carcinomas with an adenoma component , and EGF and c ERBB 2 gene product in the carcinomas without an adenoma component . ^^^ TGF alpha might play a crucial role in carcinomas arising from adenoma , while EGF and c ERBB 2 gene products are strongly indicative of de novo carcinomas . . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Epidermal growth factor ( EGF ) and transforming growth factor alpha ( TGF alpha ) stimulate cellular proliferation , whereas epidermal growth factor receptor ( EGFR ) and c erb B 2 oncoprotein are involved in the regulation of cellular growth . ^^^ The present study investigated the prognostic value of these growth factors ( EGF and TGF alpha ) and oncogene products ( EGFR and c erb B 2 ) in TCC UUT . ^^^ Immunohistochemically , EGF was recognized as positive in 50 . 4 % of the samples , TGF alpha in 27 . 8 % , EGFR in 41 . 3 % , and c erb B 2 oncoprotein in 6 . 8 % . ^^^ The immunoreactivity for EGF and c erb B 2 oncoprotein was significantly ( P < 0 . 05 ) correlated with both stage and grade , whereas TGF alpha correlated only with stage and EGFR only with grade . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Transgenic mice expressing either the neu proto oncogene or transforming growth factor ( TGF alpha ) in the mammary epithelium develop spontaneous focal mammary tumors that occur after a long latency . ^^^ Since the epidermal growth factor receptor ( EGFR ) and Neu are capable of forming heterodimers that are responsive to EGFR ligands such as TGF alpha , we examined whether coexpression of TGF alpha and Neu in mammary epithelium could cooperate to accelerate the onset of mammary tumors . ^^^ To test this hypothesis , we interbred separate transgenic strains harboring either a mouse mammary tumor virus / TGF alpha or a mouse mammary tumor virus / neu transgene to generate bitransgenic mice that coexpress TGF alpha and neu in the mammary epithelium . ^^^ Female mice coexpressing TGF alpha and neu developed multifocal mammary tumors which arose after a significantly shorter latency period than either parental strain alone . ^^^ Taken together , these observations suggest that Neu and TGF alpha cooperate in mammary tumorigenesis through a mechanism involving Neu and EGFR transactivation . . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The fusion protein consists of the antigen binding domain of the ErbB 2 specific MAb , FRP 5 , and the natural EGFR ligand , TGF alpha , inserted at different positions in truncated Pseudomonas exotoxin A . ^^^ ScFv ( FRP 5 ) TGF alpha ETA protein displayed binding to EGFR and ErbB 2 , thereby inducing activation of the receptors , which was dependent on the cellular context and the level of EGFR and ErbB 2 expression . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Overexpression of growth factor receptors ( EGF receptor , c erbB 2 , c erbB 3 , TGF beta receptor 1 3 ) , growth factors ( EGF , TGF alpha , TGF beta 1 3 , aFGF , bFGF ) , adhesion molecules ( ICAM 1 , ELAM 1 ) and gene mutations ( p 53 , K ras , DCC , APC ) are present in a significant number of these tumors . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| When EGF and TGF alpha were both expressed , there was little or no expression of c erbB 2 . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Activation of erbB 2 and c src kinase were also observed in the epidermis of TGF alpha transgenic mice where expression of human TGF alpha was targeted to basal keratinocytes with the human K 14 promoter . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Several growth factors ( TGF alpha , HGF ) and their receptors ( EGFR , MET , ERBB 2 ) were expressed in the primitive IBS cells . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : EGF , transforming growth factor alpha ( TGF alpha ) , EGF receptor ( EGF R ) , and c erb B 2 were determined immunohistochemically in formalin fixed paraffin embedded tumor samples of 30 patients with locally confined RCCs . ^^^ On the contrary , there was a significant correlation between EGF and TGF alpha ( p < 0 . 001 ) , EGF and EGF R ( p = 0 . 028 ) , EGF R and c erb B 2 ( p = 0 . 0009 ) , and inversely related between TGF alpha and tumor stage ( p = 0 . 047 ) and between EGF R and malignancy grade ( p = 0 . 03 ) . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The computer analysis program , COMPARE , was used to search for cytotoxicity patterns in the NCI drug screen database that were highly correlated with EGF receptor , TGF alpha , or c erbB 2 mRNA expression patterns . ^^^ RESULTS : EGF receptor mRNA and TGF alpha mRNA levels were highest in cell lines derived from renal cancers , and c erbB 2 mRNA levels were highest in cells derived from breast , ovarian , and colon cancers . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The expression of genes involved in mitotic signal pathway ( EGF , TGF alpha , EGF R , erbB 2 , erbB 3 , c myc and c H ras ) was determined immunocytochemically . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Interestingly , while TGF alpha was expressed in the majority of PCA lines , the ligand Neu Differentiation Factor / Heregulin ( NDF ) was expressed only in an immortalized , non transformed prostate epithelial line . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the neuroregulin of glial origin neu differentiation factor ( NDF ) was found to facilitate the action of TGF alpha , suggesting that other growth factors may exert their biologic effects on GnRH neuronal function via a glia / neuron interaction . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| We have generated transgenic rats overexpressing the human transforming growth factor alpha ( TGF alpha ) and c erbB 2 genes in the mammary gland under the control of the mouse mammary tumour virus ( MMTV ) long terminal repeat promoter , and have analysed multiple lines of these rats to the second ( F 2 ) generation . ^^^ These animals model a spectrum of lesions found in human breasts and suggest that TGF alpha overexpression can act at a relatively early stage in the pathogenesis of breast cancer in the rat , resulting in a predominantly hyperplastic response , whereas overexpression of c erbB 2 plays a role in the induction of various benign lesions and more advanced breast carcinomas . . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| We have determined the expression of transforming growth factor alpha ( TGF alpha ) , amphiregulin ( AR ) , CRIPTO , the epidermal growth factor receptor ( EGFR ) , erbB 2 , erbB 3 , and tumor angiogenesis in a series of 195 patients with stage 1 IIIA non small cell lung cancer ( NSCLC ) treated with radical surgery to define their usefulness as prognostic indicators of survival . ^^^ A direct association was also detected for overexpression of TGF alpha and of erbB 2 or erbB 3 , respectively . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| In addition to these , only vascular endothelial growth factor , insulin like growth factor 1 and 2 , had significant mitogenic activity , whereas hepatocyte growth factor , nerve growth factor beta , platelet derived growth factors , basic fibroblast growth factor , EGF , transforming growth factor alpha ( TGF alpha ) , neu differentiation factor , and TGF beta were inactive . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| To define the role that TGF alpha production played in induction of tumorigenicity , a non tumorigenic TGF alpha negative clone of ErbB 2 overexpressing cells ( E 2 cells ) was transfected with an expression vector for TGF alpha ( E2alpha cells ) . ^^^ In vitro , ErbB 2 co immunoprecipitated with EGFR in lysates of unstimulated E6T and E2alpha TGF alpha producing cells , indicating that the lower TGF alpha levels were sufficient to induce in vitro heterodimerization . ^^^ These studies suggest that induction of the tumorigenic phenotype depends on achieving a threshold level of TGF alpha sufficient to activate downstream signalling by ErbB 2 containing active heterodimers . . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Fifty nine paraffin embedded astrocytic gliomas ( four WHO grade 1 , 21 WHO grade 2 , 17 WHO grade 3 and 17 glioblastomas , WHO grade 4 ) were immunohistochemically investigated for expression of transforming growth factor alpha ( TGF alpha ) , epidermal growth factor receptor ( EGF R ) and oncoprotein c erbB 2 by semiquantitative assessment . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Concentrating on ErbB 1 and two of its ligands , epidermal growth factor ( EGF ) and transforming growth factor alpha ( TGF alpha ) , and the Neu differentiation factor ( NDF / neuregulin ) and one of its receptors , ErbB 3 , we show that ligand binding variably accelerates endocytosis of the respective ligand receptor complex . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| In comparison , pancreatic carcinoma cell lines commonly demonstrated overexpression of EGFR , erbB 2 , TGF alpha , Met / HGFR , VEGF , and KGF , but they consistently showed marked down regulation of amphiregulin mRNA expression . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Exogenous TGF alpha activated EGFR , ErbB 2 and MAPK , whereas EGF activated only the EGFR . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| In the mammary gland , ER mediated mechanisms have been shown to regulate : various growth factors , such as TGF alpha and TGF beta ; enzymes , such as cathepsin D and plasminogen activator ; proto oncogenes , such as c fos , c myc and HER 2 / neu ; cyclines and other regulatory substances that provide signaling systems for cell division and differentiation ; other steroid receptors and epidermal growth factor receptors . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Sixty prostatic TURP ( transurethral resection of the prostate ) specimens exhibiting atypical adenomatous hyperplasia ( AAH ) and / or prostatic intraepithelial neoplasia ( PIN ) lesions were assayed by immunohistochemistry for androgen receptor ( AR ) , epidermal growth factor receptor ( EGFR ) , c erbB 2 , transforming growth factor alpha ( TGF alpha ) , vascular endothelial growth factor ( VEGF ) , fibroblast growth factor 2 ( FGF 2 ) , MIB 1 , E cadherin , and high molecular weight keratin . ^^^ A similar growth factor and receptor profile was demonstrated in the secretory epithelium of high grade PIN and carcinoma with a tendency to higher expression of membranous EGFR and c erbB 2 and cytoplasmic TGF alpha , and lower levels of FGF 2 than in low grade PIN or BPH glands . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| TGF alpha stimulated tyrosine phosphorylation of both the EGF receptor and c erbB 2 receptor in all four cell lines . ^^^ The inhibitor ZM 252868 , at concentrations > or =0 . 3 microM , completely inhibited TGF alpha stimulated tyrosine phosphorylation of the EGF receptor and reduced phosphorylation of the c erbB 2 protein . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The panel of potential SEBs of malignancy include p 53 , cytomorphometric indices , ploidy , PNCA , erbB 2 , erbB 3 , EGF receptor , TGF alpha tumor associated glycoprotein 72 , fatty acid synthetase and Lewis Y antigen . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| But no obvious difference of TGF alpha or c erbB 2 expression was found between HCC with and without recurrence , or with and without extrahepatic metastasis . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Tumor suppressor genes ( p 53 , p 16 ) , oncogenes ( c erbB 2 , H ras , K ras , cyclin D 1 , src ) , and growth factor / receptor ( TGF alpha , EGFR ) seem to cause the malignant transformation of Barrett ' s esophagus . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| We have reported that the transformation of human lung epithelial cells by c erbB 2 also requires an active ErbB 1 ( EGF receptor ) and the autocrine production of its ligand , TGF alpha . ^^^ Inhibition of ErbB 2 kinase activity by tyrphostin AG 825 prevented the constitutive activation of STAT 3 in the TGF alpha producing , ErbB 1 expressing cell line . ^^^ Our results demonstrate a requirement for ErbB 2 kinase activity to establish constitutive STAT 3 activation resulting from an autocrine ErbB 1 / TGF alpha loop . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Earlier studies demonstrated that a tumorigenic clone from T antigen immortalized nontumorigenic cells overexpressing ErbB 2 endogenously produced high levels of transforming growth factor ( TGF ) alpha , and that reducing TGF alpha by 93 % eliminated tumorigenicity . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| We studied the expression of TGF alpha and two EGFRs ( HER 1 and HER 2 ) in gastrointestinal stromal tumours ( GISTs ) of the stomach ( n = 9 ) and small intestine ( n = 6 ) using standard immunostaining techniques in paraffin embedded sections . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Then we examined the expression of p 53 , cripto , cyclin E , c met , c erbB 2 and TGF alpha immunohistochemically and compared the results between the two groups . ^^^ No obvious differences were observed in c erbB 2 , TGF alpha and c met expression . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Basal growth of MCF 7 cells was unaffected by co administration of the growth factors EGF , TGF alpha , IGF 1 , and IGF 2 , and the new agents did not inhibit EGFR and c erbB 2 autophosphorylation in cell lysates from MDA 468 or SkBr 3 cells , respectively , suggesting that receptor tyrosine kinases are not targets for these compounds . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| While interactions of WT and variant TGF alpha with the ErbBs all result in ErbB 2 activation , they produce different biological consequences , suggesting that the various TGF alpha precursors differentially modulate ErbB signaling . . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Immunoreactivity for EGF R , TGF alpha , p 53 and c erbB 2 with paraffin embedded carcinoma tissue was investigated using labeled streptavidin biotin methods . ^^^ Positive rates of carcinoma cells were 27 % , 33 % , 32 % and 26 % for EGF R , TGF alpha , p 53 and c erbB 2 , respectively . ^^^ By univariate analysis , significant differences in overall survival and disease free survival were noted according to the co expression of EGF R and TGF alpha ( p < 0 . 0001 , p < 0 . 0001 ) , co expression of EGF R and c erbB 2 ( p = 0 . 0029 , p = 0 . 0028 ) , nodal status ( p = 0 . 0028 , p = 0 . 0001 ) , tumor size ( p = 0 . 0001 , p < 0 . 0001 ) and c erbB 2 expression ( p = 0 . 0034 , p = 0 . 018 ) , respectively . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The mRNA content for six ligands [ EGF , transforming growth factor alpha ( TGF alpha ) , amphiregulin ( AR ) , betacellulin ( betaCL ) , heparin binding EGF like growth factor ( HB EGF ) , epiregulin ( EPI ) ] and two receptors [ EGF receptor 1 Human EGF Receptor ( HER 1 ) and 2 ( HER 2 ) ] was examined by a newly developed quantitative reverse transcription PCR method . ^^^ Five ligands and two receptors ( HER 1 and HER 2 ) were present in median concentrations of ( 10 ( 21 ) mol / microg RNA ) 0 . 39 ( AR ) , 11 ( betaCL ) , 2 . 4 ( EPI ) , 40 ( HB EGF ) , 1 . 4 ( TGF alpha ) , 75 ( HER 1 ) , and 39 , 000 ( HER 2 ) . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The expression of epidermal growth factor ( EGF ) receptor ( P = 0 . 037 ) , transforming growth factor alpha ( TGF alpha ; P < 0 . 001 ) , and HER 2 ( P = 0 . 066 ; positive trend ) correlated with activation of ERK1 / 2 . ^^^ In a multivariate analysis , both TGF alpha ( P < 0 . 0001 ) and HER 2 ( P = 0 . 045 ) were independently correlated with ERK1 / 2 activation . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : The goal of this work was to study the expression of epidermal growth factor receptor ( by use of monoclonal antibody EGFR 1 ) and HER 2 / neu ( by use of monoclonal antibody EGFR 2 ) , as well as EGFR activation [ phosphorylated EGFR ( P EGFR ) ] and autocrine stimulation [ ligand transforming growth factor alpha ( TGF alpha ) ] markers in a series of 24 testicular tumors [ 18 nonseminomatous germ cell tumors ( GCTs ) , 1 Leydig cell tumor , and 5 seminomatous GCTs ] . ^^^ EXPERIMENTAL DESIGN : Paraffin embedded sections of tumors were studied immunohistochemically for beta human chorionic gonadotropin ( beta HCG ) , EGFR 1 , HER 2 / neu , TGF alpha , and P EGFR expression . ^^^ Expression of HER 2 / neu , TGF alpha , and P EGFR was detected in 25 , 36 , and 27 % of EGFR positive , nonseminomatous GCTs , respectively . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| To determine whether MEC and ACC have different molecular characteristics , we examined the expression of erbB 2 , erbB 3 , epidermal growth factor receptor ( EGFR ) , and transforming growth factor alpha ( TGF alpha ) , important molecular features in other malignancies . ^^^ STUDY DESIGN / METHODS : Archival tissue sections of 22 MEC and 6 ACC tumors of the major salivary glands were evaluated immunohistochemically for expression of erbB 2 , erbB 3 , EGRF , and TGF alpha . ^^^ Conversely , erbB 2 , erbB 3 , EGFR , and TGF alpha may have a role in the development and progression of MEC . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The expression of epidermal growth factor ( EGF ) , epidermal growth factor receptor ( EGFR ) , transforming growth factor alpha ( TGF alpha ) , and of c erbB 2 was immunohistochemically investigated in resected gastric carcinoma ( in 39 cases of superspreading type and in 11 cases of penetrating type ) , to understand the differential biological features of these two types of gastric carcinoma . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Abnormal expression of TGF alpha , EGF R and c erb B 2 has been demonstrated in several human malignancies . ^^^ METHODS : The immunohistochemical expression of TGF alpha , EGF R , and c erb B 2 was studied in paraffin material of 62 clinical Wilms tumors . ^^^ RESULTS : Generally , TGF alpha , EGF R , and c erb B 2 were expressed in tissue of the normal kidney and at variable levels in the three cell types of Wilms tumor , i . e . , blastemal , epithelial , and stromal cells . ^^^ Immunoreactive blastema cells were found in 48 % , 44 % , and 34 % of tumors for TGF alpha , EGF R , and c erb B 2 , respectively . ^^^ It was found that TGF alpha , EGF R , and c erb B 2 blastemal and epithelial expression gradually increased from T 1 to T 3 . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| EXPERIMENTAL DESIGN : The localization of EGF r , TGF alpha , and erbB 2 was evaluated immunohistochemically in 60 archival specimens of SCC of the lung and in 60 lung specimens without cancer . ^^^ RESULTS AND CONCLUSIONS : The expression of EGF r , erbB 2 , and TGF alpha were significantly higher in SCC and associated precancerous lesions than in the normal bronchial epithelium and hyperplastic lesions of noncancer specimens . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| AR induced a slight induction of ErbB 2 on duct cells , whereas TGF alpha resulted in overexpression of the EGF receptor in cells within tubular complexes . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| In contrast to previously characterized chimeras of EGF with NRG 1 or TGF alpha , these variants did not only show high binding affinity for ErbB 2 / ErbB 3 heterodimers but also for ErbB 3 alone . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Many genes have been selected as targets for antisense therapy , including HER 2 / neu , PKA , TGF alpha , EGFR , TGF beta , IGFIR , P 12 , MDM 2 , BRCA , Bcl 2 , ER , VEGF , MDR , ferritin , transferrin receptor , IRE , C fos , HSP 27 , C myc , C raf and metallothionein genes . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Inhibition of ErbB 2 and ErbB 3 expression by quercetin prevents transforming growth factor alpha ( TGF alpha ) and epidermal growth factor ( EGF ) induced human PC 3 prostate cancer cell proliferation . ^^^ Co treating PC 3 cells with quercetin significantly attenuated EGF and TGF alpha induced growth and phosphorylation of ErbB 2 , ErbB 3 , c Raf , MAPK kinase 1 / 2 ( MEK1 / 2 ) , MAPK , Elk 1 and Akt 1 . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| We have investigated the protein expression pattern of the four ErbB receptors EGFR , Her 2 / neu , Her 3 and Her 4 , and correlated it with their putative ligands EGF , TGF alpha and HRG in 74 women with invasive breast cancer . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| METHODS : Expression patterns for terminal differentiation markers were used to characterize tumor types and to study tumor progression in transgenic mouse models of mammary neoplasia ( mice overexpressing Neu ( Erbb 2 ) , Hras , Myc , Notch 4 , SV 40 TAg , Tgfa , and Wnt 1 ) , in spontaneous mammary carcinomas , and in mammary neoplasms associated with infection by the mouse mammary tumor virus ( MMTV ) . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The extent of TGF alpha stimulated migration on collagen in these assays could be associated with erbB 2 expression levels . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Previous studies have shown that constitutive activation of epidermal growth factor receptor ( EGFR ) and ErbB 2 by elevated autocrine transforming growth factor alpha ( TGF alpha ) expression plays an important role in colon cancer progression . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| TGF alpha , c erbB 2 expression and neoangiogenesis in vulvar squamous cell carcinoma . ^^^ BACKGROUND : TGF alpha and c erbB 2 are important mediators of tumor neoangiogenesis linked to the epidermal growth factor receptor . ^^^ Thus , we analyzed TGF alpha c erbB 2 and tumor neoangiogenesis in vulvar carcinoma and determined their prognostic significance . ^^^ Tumors were stained immunohistologically for TGF alpha , c erbB 2 and factor 8 antigen . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| TGF alpha and ErbB 2 production in synovial joint tissue : increased expression in arthritic joints . ^^^ Concomitant expression of TGF alpha , EGFR , and ErbB 2 gives a strong proliferative drive in vitro and in vivo . ^^^ We aimed to determine whether TGF alpha , EGFR , and ErbB 2 are present in human synovial joints , especially during rheumatoid arthritis ( RA ) . ^^^ TGF alpha mRNA and TGF alpha , ErbB 2 , EGFR , and CD 68 immunoreactivity were detected in knee synovial biopsies ( 6 RA / 2 OA / 6 control ) using in situ hybridization and immunohistochemistry . ^^^ The increased expression of TGF alpha and ErbB 2 in RA SF and SM may give rise to an abnormal growth pattern , contributing to inflammatory synovial hyperplasia . . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Six genes were over expressed ( ERBB 2 , TGFA , HB EGF , AREG , EREG and EPGN ) , 3 were under expressed ( ERBB 1 , ERBB 4 and NRG 4 ) and 2 were over or under expressed ( ERBB 3 and BTC ) . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The family of factors related to EGF has also expanded recently and now includes transforming growth factor alpha , heparin binding EGF , amphiregulin , cripto and heregulin , as well as several other potential ligands for the c erbB 2 2 receptor . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Growth of epithelial ovarian cancer is influenced by several factors including transforming growth factor alpha and transforming growth factor beta , macrophage colony stimulating factor , tumor necrosis factor alpha , interleukin 1 and interleukin 6 , c erb B 2 ( HER 2 / neu ) , and mutant p 53 . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| C mel , c erb B 2 , c myc , c src 1 , p 53 , platelet derived growth factor A chain , gro , transforming growth factor alpha , epidermal growth factor receptor and tissue plasminogen activator were all expressed in at least some cell lines . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Altered gene expression of c myc , epidermal growth factor receptor , transforming growth factor alpha , and c erb B 2 in an immortalized human breast epithelial cell line , HMT 3522 , is associated with decreased growth factor requirements . ^^^ The EGF independence of S 2 was accompanied by an overexpression of the mRNAs for epidermal growth factor receptor ( EGF R ) , transforming growth factor alpha , and c erb B 2 as compared to the EGF dependent subline ( S 1 ) . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Some endometrial cancers and endometrial adenocarcinoma cell lines show amplified expression of proto oncogenes ( fos , fms , myc , myb , neu , and erb B ) and augmented production of growth factors ( colony stimulating factor 1 , epidermal growth factor , transforming growth factor alpha , and transforming growth factor beta ) and epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| All of the oncogenes tested , including activated human Ha ras , human transforming growth factor alpha , activated rat neuT , and human c erbB 2 activated by a point mutation in the transmembrane domain , caused transformation of the HC 11 cells , as shown by tumor formation in nude mice . ^^^ HC 11 cells expressing the neuT and activated c erbB 2 genes synthesized beta casein in response to lactogenic hormones , whereas those expressing the Ha ras or transforming growth factor alpha oncogenes were no longer able to respond to the lactogenic hormones . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The expression of genes which may be involved in the regulation of human mammary epithelial cell growth [ transforming growth factors alpha and beta ] and tumorigenesis [ c myc , erbB 2 , epidermal growth factor receptor ( EGFR ) , Ha ras , pS 2 ] has been compared in similarly cultured normal cell strains and tumor cell lines . ^^^ Steady state mRNA levels for transforming growth factor beta , erbB 2 , c myc , and Ha ras in the normal cells were greater than or comparable to those in all of the breast tumor lines . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Overexpression of HER 2 / neu , transforming growth factor alpha , and p 53 proteins have all been associated with poor prognosis in women with endometrial cancer . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| In addition , transforming growth factor alpha increased cisplatin induced cytotoxicity against NIH 3T3 cells overexpressing an epidermal growth factor receptor / c erbB 2 chimera . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Transgenic mouse strains overexpressing the oncogenes transforming growth factor alpha , neu , int 3 , polyoma virus middle T antigen , and simian virus 40 large T antigen have been previously shown to develop spontaneous mammary neoplasia . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Growth factor independent proliferation of rat mammary carcinoma cells by autocrine secretion of neu differentiation factor / heregulin and transforming growth factor alpha . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The epidermal growth factor receptor couples transforming growth factor alpha , heparin binding epidermal growth factor like factor , and amphiregulin to Neu , ErbB 3 , and ErbB 4 . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The EGF family includes EGF , transforming growth factor alpha , heparin binding EGF , amphiregulin , beta cellulin , epiregulin , and heregulins , whereas the receptor family ( the erbB genes ) consists of erbB 1 ( EGF receptor , EGF R ) , erbB 2 , erbB 3 , and erbB 4 . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Reduced ability of transforming growth factor alpha to induce EGF receptor heterodimerization and downregulation suggests a mechanism of oncogenic synergy with ErbB 2 . ^^^ The epidermal growth factor receptor ( EGFR ) is activated by a variety of ligands including EGF and transforming growth factor alpha ( TGFalpha ) , whereas no ligand for the homologous ErbB 2 oncoprotein has yet been identified . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Qualitatively similar results were found in mammary tumors from mice bitransgenic for the neu and transforming growth factor alpha genes ( both driven by the mouse mammary tumor virus promoter ) . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Increases of as much as 49 fold compared to parental levels were observed in transforming growth factor alpha , epidermal growth factor receptor , c erbB 2 , and / or c erbB 3 mRNA expression in 14 of the 17 resistant sublines . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Therefore , the lysability of MCF 10A cells overexpressing activated oncogenes ( Ha ras , erbB 2 , and a mutated p 53 ) , growth factors [ transforming growth factor alpha ( TGFalpha ) ] , or cAMP dependent protein kinase A subunits ( RIalpha , RIIbeta , and Calpha ) was evaluated comparatively at different effector : target ratios by a 51Cr release assay . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Human cDNAs corresponding to two epidermal growth factor related products that are overexpressed in human breast cancers , that for c erbB 2 ( HER 2 ) and for transforming growth factor alpha ( TGFalpha ) , have been cloned downstream of the mouse mammary tumor virus ( MMTV ) long terminal repeat promoter and injected into the pronucleus of fertilized oocytes of Sprague Dawley rats to produce transgenic offspring . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| We recently demonstrated that human lung epithelial cells , overexpressing ErbB 2 , formed tumors in nude mice only when high levels of transforming growth factor alpha ( TGFalpha ) were produced . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Evidence is provided for trophoblast cell expression of epidermal growth factor receptor ( EGFR ) , ErbB 2 , fibroblast growth factor receptor 1 ( FGFR 1 ) , transforming growth factor alpha , and heparin binding EGF . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The developed method has enabled us to demonstrate that prostate stromal cells in primary culture express EGF , heparin binding EGF ( HB EGF ) , amphiregulin , betacellulin , and epiregulin as well as the HER 1 and HER 2 receptors , whereas no transforming growth factor alpha mRNA is found . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| In contrast , BIBX1382BS was more potent at inhibiting signaling induced by TGF alpha than that induced by neuregulin 1 beta1 or anti ErbB 2 agonist antibodies . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| METHODS : Immunohistochemistry was used to compare expression of EGFR , c erbB 2 , c erbB 3 , epidermal growth factor , heparin binding epidermal growth factor like growth factor , and transforming growth factor alpha in bronchial biopsy specimens from normal and asthmatic subjects . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Prostate tissue expressed the EGF receptor ( HER 1 ) and HER 2 , and the ligands EGF , transforming growth factor alpha ( TGFalpha ) , heparin binding ( HB ) EGF , betacellulin and amphiregulin . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| The expression of COX 2 was then related to age , histological grade , nodal status , oestrogen receptor status , p 53 expression , c erb B 2 overexpression , mitotic counts , MIB 1 labelling index , apoptotic index , sialyl Tn expression , transforming growth factor alpha expression , microvessel density , and disease free survival in 46 patients with invasive ductal breast carcinoma . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Over the past year , the field has progressed from having a complete absence of 10 ray crystal structures to having eight such structures ; ErbB 2 alone or complexed with the two monoclonal antibodies pertuzumab ( Genentech Inc / Roche Holdings AG / Chugai Pharmaceutical Co Ltd ) and trastuzamab , ErbB 3 without a ligand , EGFR with a ligand bound in an unactivated monomeric conformation , and EGFR with either epidermal growth factor ( EGF ) or transforming growth factor alpha ( TGFalpha ) in a 2 : 2 dimeric complex . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Responders exhibited variable levels of inhibition of p ErbB 1 , p ErbB 2 , p Erk1 / 2 , p Akt , cyclin D 1 , and transforming growth factor alpha . ^^^ Clinical response was associated with a pretreatment TUNEL score > 0 and increased pretreatment expression of ErbB 2 , p ErbB 2 , Erk1 / 2 , p Erk1 / 2 , insulin like growth factor receptor 1 , p 70 S6 kinase , and transforming growth factor alpha compared with nonresponders . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Transforming growth factor alpha or heparin binding epidermal growth factor induced activation of EGFR and HER 2 was inhibited by ERRP in colon and breast cancer cells expressing high levels of EGFR or HER 2 . ^^^ ERRP and trastuzumab , but not cetuximab , attenuated heregulin alpha induced activation of colon and breast cancer cells that expressed high levels of HER 2 . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| We studied epithelial expression of EGF , transforming growth factor a , amphiregulin , heregulin ( HRG ) , betacellulin ( BTC ) , and their receptors , EGFR , HER 2 , and HER 3 , by immunohistochemical analysis in resected bronchial tissue from 20 subjects with ( forced expiratory volume in 1 second [ FEV ( 1 ) ] < 75 % of predicted value ) and 18 without ( FEV ( 1 ) > 85 % predicted value ) COPD . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Candidate prognostic biomarkers for breast cancer include elevated proliferation indices such as Ki 67 and proliferating cell nuclear antigen ( PCNA ) ; ER and PR overexpression ; markers of oncogene overexpression such as c erbB 2 , TGF a and EGFr ; indicators of apoptotic imbalance including overexpression of bcl 2 and an increased bax / bcl 2 ratio ; markers of disordered cell signaling such as p 53 nuclear protein accumulation ; alteration of differentiation signals such as overexpression of c myc and related proteins ; loss of differentiation markers such as TGF b 2 receptor and retinoic acid receptor ; and alteration of angiogenesis proteins such as VEGF overexpression . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| Here , this same weight cycling protocol was applied to MMTV Neu female mice , which develop MTs at a much younger age than do TGF a mice . ^^^ |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01135 and P04626 |
Pubmed |
SVM Score :0.0 |
| NA |
|