| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| PSA is mainly responsible for gel dissolution in freshly ejaculated semen by proteolysis of the major gel forming proteins semenogelin 1 and 2 and fibronectin . ^^^ |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| PSA is mainly responsible for gel dissolution in freshly ejaculated semen by proteolysis of the major gel forming proteins , semenogelin 1 and 2 , and fibronectin . ^^^ |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| Functionally and structurally PSA is a kallikrein like serine protease , and its physiologic role is degradation of the major proteins of seminal coagulum ( semenogelin 1 and 2 , fibronectin ) , which leads to semen liquefaction . ^^^ |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : In semen , prostate specific antigen ( PSA or hK 3 ) digests the gel proteins semenogelin 1 and 2 , resulting in liquefaction and the release of motile spermatozoa . ^^^ METHODS : The proteolysis of human semenogelin 1 ( SgI ) and 2 ( SgII ) by PSA was characterized by purification of generated SgI and SgII fragments , N terminal sequencing , and mass spectrometry . ^^^ |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| PSA is a serine protease with substrates that include semenogelin 1 and 2 , insulin like growth factor binding protein 3 , fibronectin , and laminin . ^^^ |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| In spite of evidence demonstrating the importance of the seminal coagulation and liquefaction process in terms of global fertility and despite the fact that the seminal coagulum is composed of fibrin like material , it has always been addressed from the perspective of High Molecular Weight Seminal Vesicle ( HMW SV ) proteins ( Semenogelin 1 and 2 ) and their cleavage by prostate specific antigen rather than the conventional hemostatic factors . ^^^ |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| For this purpose we inserted different sequences of known PSA cleavage sites from the natural substrate of PSA , semenogelin 1 , into the activation peptide of factor 10 . ^^^ |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| Human seminal plasma contains high concentrations of prostatic acid phosphatase ( PAP ) , prostate specific antigen ( PSA ) , beta microseminoprotein ( MSP ) , semenogelin 1 ( SgI ) , and semenogelin 2 ( SgII ) , whereas only PAP and MSP are present in rodents . ^^^ |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| Truncated semenogelin 1 binds zinc and is cleaved by prostate specific antigen . ^^^ |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| In spite of the size difference , SgI ( 43 ) has many properties in common with SgI ( 50 ) , such as a very high iso electric point and susceptibility to proteolytic degradation by prostate specific antigen . ^^^ |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| In semen , the gel proteins SgI and SgII ( semenogelins 1 and 2 ) are digested by PSA ( prostate specific antigen ) , resulting in liquefaction and release of motile spermatozoa . ^^^ We characterized the binding of Zn2+ to SgI and SgII and found evidence that these proteins are involved in regulating the activity of PSA . ^^^ Moreover , Zn2+ inhibited PSA was activated by exposure to SgI or SgII . ^^^ |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| PCI was found to inhibit the PSA catalyzed degradation of insoluble coagula Sg 1 + 2 by forming a PSA PCI complex . ^^^ |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| On the basis of the PSA cleavage map for Sg 1 and 2 , a series of small peptides ( i . e . , < or = 7 amino acids ) was synthesized and coupled at the COOH terminus to 7 amino 4 methyl coumarin . ^^^ |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04279 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
|