| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| However , the TFP linewidth in the presence of Ca 2 ( + ) bound S100a was 65 Hz greater than in the presence of Ca 2 ( + ) bound S100b . ^^^ This suggests a slower TFP exchange rate for S100a than for S100b . ^^^ Thus , the TFP linewidths observed for each isoform may reflect differences in structural and modulatory properties of the Ca 2 ( + ) dependent hydrophobic domains on S100a and S100b . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| This is exemplified by the isolation and separation of a group of Ca ( 2+ ) activated proteins , Calmodulin , S100a and S100b , from bovine brain extract , using a melittin Eupergit C affinity column which is developed with Ca ( 2+ ) chelator gradients . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| In contrast , the binding affinity of TRP to S100b protein in the presence and absence of metal ions was lower than to S100a and S100ao proteins . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| The fluorescence intensity of 2 p toluidinylnaphthalene 6 sulfonate ( TNS ) bound to S100a or S100a0 protein decreased by adding TFP in the presence of Ca2+ , while that bound to S100b protein decreased by adding TFP in the presence of Zn2+ , indicating that TFP binds to S100a protein and S100a0 protein in a Ca2+ dependent manner and to S100b protein in a Zn2+ dependent manner . ^^^ From these results together with other experimental findings it was suggested that ( 1 ) TFP binds to S100a protein and S100a0 protein in the presence of Ca2+ , with half saturation points of 18 and 3 microM , respectively , ( 2 ) TFP binds to S100b protein only in the presence of Zn2+ , ( 3 ) alpha subunit of S 100 protein binds to TFP specifically in a Ca2+ dependent manner and beta subunit in a Zn2+ dependent manner . . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| These results suggest that a predominant form of S 100 protein in human myocardial cells is not S100a ( alpha beta ) or S100b ( beta beta ) , but S100a0 ( alpha alpha ) . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| The immunohistochemical study revealed that S 100 alpha is mainly localized in slow twitch muscle fibers , whereas the beta subunit of S 100 protein ( S 100 beta ) was not detected in both types of muscle fibers , an observation indicating that the predominant form of S 100 protein in the slow twitch muscle fiber is not S100a or S100b , but S100a0 . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Calcium and zinc binding properties of bovine brain S 100 alpha alpha , S100a ( alpha beta ) , and S100b ( beta beta ) protein : Zn2+ regulates Ca2+ binding on S100b protein . ^^^ Flow dialysis measurements of calcium binding to bovine brain S 100 alpha alpha , S100a ( alpha beta ) , and S100b ( beta beta ) proteins in 20 mM Tris HCl buffer at pH 7 . 5 and 8 . 3 revealed that S 100 proteins bind specifically 4 Ca2+ eq / mol of protein dimer . ^^^ Zinc binding studies on S100a and S 100 alpha alpha protein showed that the Trp containing S 100 proteins bind zinc more weakly than S100b protein . ^^^ Calcium binding studies on zinc bound S100a proved that calcium and zinc binding sites were distinct although there was no increase in zinc bound S100a affinity for calcium , as in S100b protein . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| A rapid separation method for bovine brain S 100 alpha alpha , S100a , and S100b protein using fast protein liquid chromatography on a Mono Q column and its application in preparation of a large amount of S 100 alpha alpha protein are described . ^^^ Incubation of S100a with calcium and KCl proved that calcium binding to the putative calcium binding sites ( site 1 alpha , 1 beta ) triggers a time and temperature dependent conformational change in the protein structure which decreases the antagonistic effect of KCl on calcium binding to sites 2 alpha and 2 beta and provokes subunit exchanges between protein dimers and the emergence of S 100 alpha alpha and S100b ( beta beta ) proteins . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Addition of exogenous S100a and S100b to brain extracts had different effects on assembly ; S100a caused an inhibition of assembly while S100b stimulated the early phase of assembly . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| The method enabled to estimate the subunit compositions of S100a , S100b , and S100a0 protein purified from bovine brain , and revealed a micro heterogeneity of S 100 subunits as applied to the mixtures of S 100 protein prepared from bovine , human and rat brain . . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| A rapid high resolution method of purification of the Trp containing S 100 proteins ( S100a , S100a ' ) and of the S100b protein has been developed . ^^^ The principle of this method is based on the fact that S100b protein becomes highly hydrophobic upon Zn2+ binding , whereas S100a and S100a ' are not affected . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Either the S100b or a mixture of S100a and S100b , both from a brain glial cell source , inhibited in vitro phosphorylation of purified F1 / GAP43 by purified PKC in a dose dependent manner . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Role of cysteines 85 alpha and 84 beta in the conformation and calcium binding properties of S 100 alpha alpha and S100b ( beta beta ) proteins . ^^^ Bovine brain S 100 alpha alpha , S100a ( alpha beta ) , and S100b ( beta beta ) protein dimers were labeled with the sulfydryl specific fluorescent probes monobromo ( trimethylammonio ) bimane ( bimane ) and 6 acryloyl 2 ( dimethylamino ) naphthalene ( acrylodan ) at cysteines 85 alpha and 84 beta . ^^^ Spectroscopic studies on the intrinsic absorption and fluorescence properties of S 100 alpha alpha and S100b proteins chemically modified on cysteines 85 alpha and 84 beta with iodoacetamide completed this study . ^^^ Calcium binding studies on bimane S 100 alpha alpha and S100b proteins showed that alkylated proteins had a much higher calcium binding affinity than native protein and that the antagonistic effect of KCl on calcium binding was much less pronounced . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Concentrations of alpha S 100 protein ( S100ao or alpha alpha form , and S100a or alpha beta form ) and beta S 100 protein ( S100b or beta beta form , and S100a or alpha beta form ) in various human tissues were determined by employing the enzyme immunoassay system specific to each subunit of bovine S 100 protein . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Three S 100 protein species ( S100a , S100b , S100a ' ) have been purified from bovine brain using a modification of standard preparative methods . ^^^ Characterization by urea / sodium dodecyl sulfate / polyacrylamide gel electrophoresis , UV absorption spectra , and fluorescence parameters provided evidence of a new tryptophan containing S 100 protein called S100a ' , which exhibits , as S100a and S100b , the properties of a Ca2+ binding protein . . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Ions binding to S 100 proteins : structural changes induced by calcium and zinc on S100a and S100b proteins . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Using a rat S100A1 cDNA probe , S100A1 expression has been documented in rat C 6 glioma cells , a cell line previously thought to express only the S100B protein . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Small angle 10 ray scattering of both S100b and a mixture of S100a and S100ao ( S100a , ao ) was measured over a protein concentration range of 1 . 5 to 10 . 0 mg / ml . ^^^ In the presence of TFP ( 1 mol TFP / mol of protein dimer ) , the radius of gyration of S100b and S100a , ao is found to be 19 . 5 + / 0 . 3A and 20 . 2 + / 0 . 3A , respectively , indicating that most S 100 proteins may exist as dimers under the conditions studied . ^^^ The observed difference ( 0 . 7 + / 0 . 3A ) in the radius of gyration between S100b and S100a , ao indicates that these dimers have different , asymmetrical shapes . . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Interaction of S100a and S100b with duck gizzard caldesmon was investigated by means of native gel electrophoresis , fluorescent spectroscopy and disulfide crosslinking . ^^^ S100a has higher affinity to caldesmon and is more effective than S100b in reversing caldesmon induced inhibition of actomyosin ATPase activity . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Other positive markers appeared after lesion included tumor necrosis factor ( TNFalpha ) and calcium binding proteins S100A and S100B , which appeared mainly within the first 48 hr after lesion and then started to decline . ^^^ The presence of S100A and S100B could be associated with both cell death after injury and the proliferation of new epithelium . 6 . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Immunostaining experiments showed the presence and localization of specific glial markers , such as glial fibrillary acidic protein and S100B , and the lack of the neuronal marker S100A . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| However , gel electrophoresis and Western blot analysis revealed proteins other than S100beta to be present in the pericardial cavity giving a falsely elevated serum S100a levels measured by immunoassay . ^^^ CONCLUSIONS : S100beta immunoassays are not specific for S100a and give a falsely elevated reading due to contaminants from the surgical field that cross react with the assay ' s antibody . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| We now know that the original two members of this family , S100A1 and S100B , can regulate a diverse group of cellular functions including cell cell communication , cell growth , cell structure , energy metabolism , contraction and intracellular signal transduction . ^^^ Interaction of these proteins with target proteins appear to involve cysteine residues ( one in S100A1 and two in S100B ) , as well as a stretch of 13 amino acids , in the middle of the molecule called the linker region , which connects the two EF hand calcium binding domains . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| To better understand the mechanisms that regulate the function of the calcium binding proteins S100A1 and S100B in developing systems , we have examined the level of , subcellular distribution of , and target proteins for these proteins in skeletal muscle ( L6S4 ) and neuronal ( PC 12 ) cell lines . ^^^ Both undifferentiated and differentiated L 6 and PC 12 cells express S100A1 and not S100B . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Identification of an S100A1 / S100B target protein : phosphoglucomutase . ^^^ Phosphoglucomutase was identified as a potential intracellular S 100 target protein because it interacted with two members of the S 100 family of calcium modulated proteins , S100A1 and S100B , in gel overlay experiments . ^^^ These results were confirmed by affinity chromatography experiments demonstrating that S100A1 and S100B bound to phosphoglucomutase Sepharose in a calcium dependent manner . ^^^ In the reverse experiment , phosphoglucomutase bound to S100A1 and S100B Sepharose in a calcium dependent manner . ^^^ These results suggest that the effects of S100A1 and S100B are not nonspecific effects of low molecular weight , acidic proteins . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| S100A1 and S100A2 can be detected in a few normal tissues only , whereas S100A4 , S100A6 , and S100B are expressed at higher levels in cancer tissues . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to evaluate the expression of the Ca ( 2+ ) binding S 100 proteins S100A1 , S100A2 , S100A3 , S100A4 , S100A6 and S100B in normal skin . ^^^ Paraffin embedded tissue of normal skin adjacent to 26 naevi , 39 primary cutaneous melanomas and 14 cutaneous melanoma metastases was incubated with polyclonal antibodies against the recombinant human S 100 proteins ( S100A1 , S100A2 , S100A3 , S100A4 , S100A6 , S100B ) using the alkaline phosphatase anti alkaline phosphatase method . ^^^ There was an intense cytoplasmatic reaction for S100A6 in all primary cutaneous melanomas and in nine of 14 ( 64 % ) metastases , S100B was positive in melanocytes and Langerhans ' cells , all primaries as well as in the metastases , S100A1 protein was not detected on any of the tissue specimens examined . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| S100A1 and S100B expression and target proteins in type 1 diabetes . ^^^ This study examines the effects of streptozotocin induced type 1 diabetes on the expression of the individual S100A1 and S100B isoforms as well as their binding proteins . ^^^ In summary , changes in the expression of S100A1 , S100B , and S 100 binding proteins occur in type 1 diabetes and represent important molecular events in the effects of insulin / insulin insufficiency on cell function . . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| The Ca ( 2+ ) binding proteins S100A1 , S100A2 , S100A4 , S100A6 and S100B were evaluated immunohistochemically in normal skin and skin appendage tumours . ^^^ Epidermal basal cells , epithelial cells of sebaceous glands , hair follicle sheet epithelia and eccrine duct reacted strongly with an antiserum against human S100A2 but were nonreactive or weakly reactive to S100A1 , S100A4 , S100A6 and S100B . ^^^ Mixed tumours of the skin containing neoplastic myoepithelial cells stained strongly for S100A2 and S100B but only faintly for S100A1 , S100A4 , S100A6 . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Annexin 6 binds S100A1 and S100B and blocks the ability of S100A1 and S100B to inhibit desmin and GFAP assemblies into intermediate filaments . ^^^ Annexin 6 , a member of a family of Ca ( 2+ ) dependent phospholipid and membrane binding proteins , interacts with the Ca ( 2+ ) regulated EF hand proteins , S100A1 and S100B , and blocks the ability of these two proteins to inhibit the assembly of desmin and glial fibrillary acidic protein ( GFAP ) into intermediate filaments in a Ca ( 2+ ) and dose dependent manner . ^^^ S100A1 and S100B each possess one annexin 6 binding site , characterized by an affinity for annexin 6 in the submicromolar range . ^^^ As S100A1 and S100B exist in solution as homodimers in which the two monomers are related by a 2 fold symmetry axis , each of the above S 100 homodimers likely crosslinks two annexin 6 molecules , a situation that appears typical of all the annexin S 100 protein complexes described thus far . ^^^ However , whereas in the cases of other annexin S 100 complexes the C terminal extension of the S 100 molecule appears indispensable for annexin binding , the annexin 6 binding site can not be restricted to the S100A1 and S100B C terminal extension . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| The fusion proteins interacting with the S100B bait were identified as S100B , S100A1 , and S100A6 . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| The levels of expression of the S100A1 , S100A2 , S100A3 , S100A4 , S100A5 , S100A6 and S100B proteins were immunohistochemically assayed and quantitatively determined in a series of 95 astrocytic tumors including 26 World Health Organization ( WHO ) grade 1 ( pilocytic astrocytomas ) , 23 WHO grade 2 ( astrocytomas ) , 25 WHO grade 3 ( anaplastic astrocytomas ) and 21 WHO grade 4 ( glioblastomas ) cases . ^^^ Very significant modifications occurred in the level of S100A1 protein expression ( and , to a lesser extent , in their of the S100A4 and S100B proteins ) in relation to the increasing levels of malignancy . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| The native form of S 100 is a mixture of two different S 100 isoforms : S100A1 ( 20 % ) and S100B ( 80 % ) . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| In this study , we further investigated the effects of S 100 ( S100B and S100A1 ) on electrical discharge activity and membrane currents of Helix neurons , using current and voltage clamp techniques . ^^^ Injection of S100A1 mimicked the effects of S100B s s on discharge activity and action potentials . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Replicating myoblasts and fused myotubes express the calcium regulated proteins S100A1 and S100B . ^^^ We investigated the expression and the subcellular localization of S100A1 and S100B , two Ca ( 2+ ) binding proteins of the EF hand type , in replicating myoblasts and fused myotubes . ^^^ Northern blot and reverse transcriptase polymerase chain reaction analyses revealed the presence of S100A1 mRNA and S100B mRNA respectively , in myoblasts . ^^^ In the present report we document that : ( 1 ) in replicating myoblasts S100B is localized to intracellular membranes , including Golgi membranes , vimentin intermediate filaments ( IFs ) and microtubule ( MT ) structures ; ( 2 ) in the same cells S100A1 is found associated with intracellular membranes ; ( 3 ) following treatment of replicating myoblasts with colchicine , a fraction of S100B remains colocalized with bundled and collapsed vimentin IFs , whereas another fraction follows the destiny of endoplasmic membranes ; ( 4 ) under the same conditions S100A1 , like a fraction of S100B , follows the collapse of the endoplasmic reticulum around the nucleus ; and ( 5 ) in fused myotubes S100A1 is found diffusely in the cytoplasm , whereas S100B is mostly found associated with vimentin IFs . ^^^ These data suggest that in the skeletal myogenic cell line used in the present study S100A1 and S100B might share binding sites on or close to intracellular membranes , but display a significant degree of target specificity with respect of IFs and MTs . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| S100B and S100A1 proteins in bovine retina : their calcium dependent stimulation of a membrane bound guanylate cyclase activity as investigated by ultracytochemistry . ^^^ The Ca 2 ( + ) binding proteins of the EF hand type , S100B and S100A1 , were detected in the outer segment of bovine retina photoreceptors where they are localized to disc membranes , as investigated by immunofluorescence and immunogold cytochemistry . ^^^ S100B and S100A1 stimulate a membrane bound guanylate cyclase activity associated with photoreceptor disc membranes in dark adapted retina in a Ca 2 ( + ) dependent manner , although with different Ca2+ requirements , as investigated by an ultracytochemical approach . ^^^ Other retinal cell types express S100B and S100A1 as well . ^^^ S100B is detected in the outer limiting membrane , fine cell processes in the outer nuclear layer and the outer plexiform layer , cell bodies in the inner nuclear layer and the ganglion cell layer , and the inner limiting membrane , whereas S100A1 has a more discrete distribution . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| The calcium modulated proteins , S100A1 and S100B , as potential regulators of the dynamics of type 3 intermediate filaments . ^^^ The Ca2+ modulated , dimeric proteins of the EF hand ( helix loop helix ) type , S100A1 and S100B , that have been shown to inhibit microtubule ( MT ) protein assembly and to promote MT disassembly , interact with the type 3 intermediate filament ( IF ) subunits , desmin and glial fibrillary acidic protein ( GFAP ) , with a stoichiometry of 2 mol of IF subunit / mol of S100A1 or S100B dimer and an affinity of 0 . 5 1 . 0 microM in the presence of a few micromolar concentrations of Ca2+ . ^^^ Binding of S100A1 and S100B results in inhibition of desmin and GFAP assemblies into IFs and stimulation of the disassembly of preformed desmin and GFAP IFs . ^^^ S100A1 and S100B interact with a stretch of residues in the N terminal ( head ) domain of desmin and GFAP , thereby blocking the head to tail process of IF elongation . ^^^ The C terminal extension of S100A1 ( and , likely , S100B ) represents a critical part of the site that recognizes desmin and GFAP . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Other Ca ( 2+ ) binding proteins such as S100A1 , S100A2 , S100B , and calmodulin did not inhibit actin activated myosin Mg ( 2+ ) ATPase activity . ^^^ Calmodulin , S100A1 , and S100B reversed the inhibitory effect of calponin in a Ca ( 2+ ) dependent manner , S100A2 had no effect , and S100C had additional inhibitory effects . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| A . , we investigated , by immunohistochemistry , the presence of different S 100 proteins ( S100A1 , S100A2 , S100A3 , S100A4 , S100A5 , S100A6 , S100A8 , S100A9 , S100A12 and S100B ) in C . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| S100A1 , the closest homologue of S100B , is capable of interaction with S100B but does not interact with S100A6 or S100A11 . ^^^ Deletion of the C terminal domain or mutation of Phe ( 87 ) and Phe ( 88 ) residues has no effect on S100B homodimerization and heterodimerization with S100A1 but drastically decreases interaction between S100B and S100A6 or S100A11 . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Effects of S100A1 and S100B on microtubule stability . ^^^ S100A1 and S100B are members of a multigenic family of Ca ( 2+ ) binding proteins of the EF hand type highly abundant in astrocyte and striated muscle cells that have been implicated in the Ca ( 2+ ) dependent regulation of several intracellular activities including the assembly and disassembly of microtubules and type 3 intermediate filaments . ^^^ In the present work we tested S100A1 and S100B for their ability to cause microtubule and / or intermediate filament disassembly in situ using triton cytoskeletons obtained from U 251 glioma cells and rat L 6 myoblasts . ^^^ Our results indicate that : ( 1 ) both proteins cause a Ca ( 2+ ) dependent disassembly of cytoplasmic microtubules in a dose dependent manner ; ( 2 ) the S100A1 and S100B inhibitory peptide , TRTK 12 , blocks the S100A1 and S100B effects on microtubules ; ( 3 ) S100A1Delta88 93 , an S100A1 mutant lacking the C terminal extension , does not affect microtubule stability ; and ( 4 ) no obvious S100A1 or S100B dependent intermediate filament disassembly could be observed under the experimental conditions used in the present study , but S100A1 and S100B dependent microtubule disassembly results in a tendency of vimentin intermediate filaments to aggregate into bundles and / or to condense . ^^^ Together , these results suggest that S100A1 and S100B probably cause microtubule disassembly by interacting with the microtubule wall , and that the two proteins do not affect intermediate filament stability via interaction with preformed intermediate filaments , in agreement with previous biochemical investigation . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Here we show that two S 100 family proteins , S100B and S100A1 , activate RAGE in concert with amphoterin inducing neurite outgrowth and activation of transcription factor NF kappaB . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| S100A1 and S100B interactions with annexins . ^^^ Previous work has shown that S100A1 and S100B bind annexin 6 in a Ca ( 2+ ) dependent manner and that annexin 6 , but not annexin 5 , blocks the inhibitory effect of S100A1 and S100B on intermediate filament assembly . ^^^ We show here that both halves of annexin 6 ( i . e . , the N terminal half or annexin 6 a and the C terminal half or annexin 6 b ) bind individual S100s on unique sites and that annexin 6 b , but not annexin 6 a , blocks the ability of S100A1 and S100B to inhibit intermediate filament assembly . ^^^ We also show that the C terminal extension of S100A1 ( and , by analogy , S100B ) , that was previously demonstrated to be critical for S100A1 and S100B binding to several target proteins including intermediate filament subunits , is not part of the S 100 surface implicated in the recognition of annexin 6 , annexin 6 a , or annexin 6 b . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Two isoforms , S100A1 and S100B , at 2 10 microM significantly inhibit active tension , stiffness and ATPase of skinned single rabbit psoas muscle fibers at sub maximal ( pCa approximately 6 . 1 5 . 6 ) , but not at maximal levels of activation ( pCa 4 . 0 ) . ^^^ S100A1 is a more potent inhibitor than S100B . ^^^ We propose S100A1 , and perhaps S100B , are viable candidates as physiological modulators of muscle contraction . . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| The expression levels of seven different S 100 proteins ( S100A1 , S100A2 , S100A3 , S100A4 , S100A5 , S100A6 , and S100B ) were characterized by immunohistochemistry in the epithelial versus connective tissues of a series of 35 colon specimens , including 6 normal samples , 5 adenomas with low grade dysplasia , 5 adenomas with high grade dysplasia , and 19 cancers . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Because of the similarity of the S100A1 dimer interface to that found for S100B , it was possible to calculate a model of the S100A1 / B heterodimer . ^^^ This model is consistent with a number of NMR chemical shift changes observed when S100A1 is titrated into a sample of ( 15 ) N labeled S100B . ^^^ As with S100B , it is likely that the second EF hand of apo S100A1 reorients dramatically upon the addition of Ca ( 2+ ) , which can explain the Ca ( 2+ ) dependence that S100A1 has for binding several of its biological targets . . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Annexin 5 , annexin 6 , S100A1 and S100B in developing and adult avian skeletal muscles . ^^^ In the present study , annexin 5 , annexin 6 ( or ANXA 5 and ANXA 6 , respectively , according to a novel nomenclature ) , S100A1 and S100B were analyzed for their subcellular localization in developing and adult avian skeletal muscles by confocal laser scanning microscopy , immunogold cytochemistry , and western blotting , and for their ability to form annexin S 100 heterocomplex in vivo by immunoprecipitation . ^^^ These four proteins displayed distinct expression patterns , ANXA 5 being the first to be expressed in myotubes ( i . e . at embryonic day 8 ) , followed by ANXA 6 ( at embryonic day 12 ) and S100A1 and S100B ( between embryonic day 12 and embryonic day 15 ) . ^^^ Immunoprecipitation studies indicated that ANXA6 / S100A1 and ANXA6 / S100B complexes formed in vivo . ^^^ Whereas , ANXA 5 was not recovered in S100A1 or S100B immunoprecipitates . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Olopatadine binds specifically to S 100 proteins , such as S100A1 , S100B , S100L , S100A12 , and S100A13 , in a Ca ( 2+ ) dependent manner but not to calmodulin . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| However , in the majority of these studies membrane bound guanylate cyclase was investigated following stimulation with natriuretic peptides , guanylin , or the Ca2+ sensor proteins , S100B and S100A1 . ^^^ Finally , S100B and S100A1 were found to colocalize with membrane bound guanylate cyclase on photoreceptor disc membranes and to stimulate enzyme activity at these sites in dark adapted retinas in a Ca2+ dependent manner . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Using a nitrocellulose overlay assay with 125I CacyBP / SIP and CacyBP / SIP affinity chromatography , we found that this protein binds purified S100A1 , S100A6 , S100A12 , S100B , and S100P but not S100A4 , calbindin D ( 9k ) , parvalbumin , and calmodulin . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| In the typical EF hand , the position of helix 3 is similar to that of another member of the S 100 protein family , calcyclin ( S100A6 ) , and less like that of other S 100 family members for which three dimensional structures are available in the calcium free state ( e . g . , S100B and S100A1 ) . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| The results of this study suggest that the calcium binding proteins S100A1 , S100A4 , S100A6 and S100A10 , but not S100B , are expressed in guinea pig smooth muscle , and could be potentially involved in the regulation of cytoplasmic Ca ( 2+ ) concentration and / or in signal transduction in smooth muscle . . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| S100A1 and S100B are members of a family of 20 kDa Ca2+ binding homodimers that play a role in signal transduction in mammalian cells . ^^^ S100A1 is the major isoform in normal heart and S100B , normally a brain protein , is induced in hypertrophic myocardium and functions as an intrinsic negative modulator of the hypertrophic response . ^^^ In order to examine the function of S100A1 , we first showed that , in contrast to S100B , S100A1 was downregulated in rat experimental models of myocardial hypertrophy following myocardial infarction or pressure overload . ^^^ Second , in co transfection experiments in cultured neonatal rat cardiac myocytes , S100A1 inhibited the alpha 1 adrenergic activation of promoters of genes induced during the hypertrophic response including the fetal genes skeletal alpha actin ( skACT ) , and beta myosin heavy chain ( MHC ) and S100B , but not the triiodothyronine ( T 3 ) activation of the promoter of the alpha MHC gene , that is normally expressed in adult myocardium . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| AIMS : To investigate whether epidermoid cysts , branchial cysts , craniopharyngiomas and cholesteatomas express S 100 proteins differentially by immunohistochemical assaying the presence of S100A1 , S100A2 , S100A3 , S100A4 , S100A5 , S100A6 and S100B . ^^^ Our data show that in contrast to S100B , which was rarely expressed , S100A1 , S100A2 , S100A4 and S100A5 were often present in these four types of epithelial lesions . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| In double labeling experiments with antibodies specific for S100A1 and S100B ( anti S 100 ) and proliferative cell nuclear antigen ( anti PCNA ) , myelin basic protein ( anti MBP ) , phosphorylated neurofilaments ( SMI 31 ) , glial fibrillary acidic protein ( anti GFAP ) , or glutamine synthetase ( anti GS ) , we detected S 100 like immunoreactivity in glial cells but never in neurons . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Redox modifications of the C terminal cysteine residue cause structural changes in S100A1 and S100B proteins . ^^^ The application of the analytical methodology based on the combination of RP HPLC and ESI MS allowed for the characterization of S nitrosylation and S glutathionylation in two representative S 100 proteins : S100A1 and S100B . ^^^ The GSNO related S nitrosylation of the conserved C terminal cysteine is strongly activated by the binding of Ca ( 2 ) to S100A1 and of Ca ( 2 ) and Zn ( 2 ) to S100B . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Analyses of alpha actinin , S100A1 and S100B were done in parallel for comparison . ^^^ At E 15 , S100A11 was found on the sarcolemma and internal membranes , likely longitudinal tubules , where the protein was co localized in part with S100A1 and S100B . ^^^ Our data suggests that , like S100A1 and S100B , S100A11 might have a role in the regulation of membrane activities , probably in relation to Ca ( 2+ ) fluxes in skeletal muscle cells . . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| METHODS : Immunohistochemical method was used to detect the expressions of S100A1 , S100B and the mutant P 53 in 36 RCC and 14 normal kidney tissues . ^^^ There was no significant correlation between the mutant P 53 and S100A1 or S100B expression ( P > 0 . 05 ) . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| A total of ten S 100 family members are reported in the literature to be expressed in brain S100A1 , S100A2 , S100A4 , S100A5 , S100A6 , S100A10 , S100A11 , S100A13 , S100B , and S100Z . ^^^ In addition , there was a 100 fold range in the mRNA levels for the six family members that were detected in mouse brain : S100A1 / S100B levels were 5 fold higher than S100A6 / S100A10 levels and 100 fold higher than S100A4 / S100A13 levels . ^^^ Although previous studies on S 100 function in the nervous system have focused on S100B , other family members ( S100A1 , S100A3 , S100A4 , S100A5 ) have been implicated in neurological diseases . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| Co expression / co location of S 100 proteins ( S100B , S100A1 and S100A2 ) and protein kinase C ( PKC beta , eta and zeta ) in a rat model of cerebral basilar artery vasospasm . ^^^ The present study reveals that , in endothelial cells , the S100B expression / location correlate well with those of PKC eta , and those of S100A1 with PKC beta . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND / AIMS : The authors investigated the expression of S100A1 , S100A6 , S100B , MelanA , and CEA in conjunctival naevi , primary acquired melanosis ( PAM ) , conjunctival melanoma , and uveal melanoma in order to assess their potential usefulness in the pathological differential diagnosis of these entities . ^^^ METHODS : Paraffin embedded sections of 18 conjunctival naevi , 14 PAM , 16 conjunctival melanomas , and 20 uveal melanomas were immunostained for S100A1 , S100A6 , S100B , MelanA , and CEA , and expression was scored semiquantitatively . ^^^ Conjunctival melanomas had high average scores for S100A1 and S100B ( 71 . 4 % , 62 . 9 % , respectively ) , while uveal melanomas also had high S100A1 but low S100B scores ( 88 . 5 % , 18 . 5 % , respectively ) . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| These effects could not be detected after stimulation with the homodimeric proteins S100A8 , S100A9 , S100A1 and S100B . ^^^ |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
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| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5T7Y6 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
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