| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| The novel dimer structure reported previously for calcyclin ( S100A6 ) is the common fold for the dimeric S100B proteins . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| S100B ( S100beta ) and S100A6 ( calcyclin ) are two 10 kDa Ca2+ and Zn2+ binding proteins coexpressed in melanoma and cell cycle regulated . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| In order to accurately determine the structural features that differentiate the various S 100 proteins , distance difference matrices and contact maps were calculated for the NMR structural ensembles of apo calcyclin and rat and bovine S100B . ^^^ Inter helical angles and distance differences for the proteins show that the positioning of helix 3 of calcyclin is most similar to that of bovine S100B , but that the helix interfaces are more closely packed in calcyclin than in either S100B structure . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| In order to understand the Ca ( 2+ ) induced structural changes in S 100 proteins , in depth comparative structural analyses were used to compare the apo and Ca ( 2+ ) bound states of calcyclin , the closely related S100B , and the prototypical Ca ( 2+ ) sensor protein calmodulin . ^^^ Using homology models of calcyclin based on S100B , a binding site in calcyclin has been proposed for the N terminal domain of annexin 11 and the C terminal domain of the neuronal calcyclin binding protein . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| In the typical EF hand , the position of helix 3 is similar to that of another member of the S 100 protein family , calcyclin ( S100A6 ) , and less like that of other S 100 family members for which three dimensional structures are available in the calcium free state ( e . g . , S100B and S100A1 ) . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| S100A1 and S100A2 can be detected in a few normal tissues only , whereas S100A4 , S100A6 , and S100B are expressed at higher levels in cancer tissues . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) binding proteins S100A6 and S100B in primary cutaneous melanoma . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to evaluate the expression of the Ca ( 2+ ) binding S 100 proteins S100A1 , S100A2 , S100A3 , S100A4 , S100A6 and S100B in normal skin . ^^^ Paraffin embedded tissue of normal skin adjacent to 26 naevi , 39 primary cutaneous melanomas and 14 cutaneous melanoma metastases was incubated with polyclonal antibodies against the recombinant human S 100 proteins ( S100A1 , S100A2 , S100A3 , S100A4 , S100A6 , S100B ) using the alkaline phosphatase anti alkaline phosphatase method . ^^^ There was an intense cytoplasmatic reaction for S100A6 in all primary cutaneous melanomas and in nine of 14 ( 64 % ) metastases , S100B was positive in melanocytes and Langerhans ' cells , all primaries as well as in the metastases , S100A1 protein was not detected on any of the tissue specimens examined . ^^^ Whereas S100B and S100A6 antibodies are useful markers for malignant melanoma , expression of S100A4 antibody is too low to be used for immunohistochemical staining . ^^^ The investigated S 100 proteins , including S100B and S100A6 , are also expressed in selected elements of normal skin . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| The Ca ( 2+ ) binding proteins S100A1 , S100A2 , S100A4 , S100A6 and S100B were evaluated immunohistochemically in normal skin and skin appendage tumours . ^^^ Epidermal basal cells , epithelial cells of sebaceous glands , hair follicle sheet epithelia and eccrine duct reacted strongly with an antiserum against human S100A2 but were nonreactive or weakly reactive to S100A1 , S100A4 , S100A6 and S100B . ^^^ Mixed tumours of the skin containing neoplastic myoepithelial cells stained strongly for S100A2 and S100B but only faintly for S100A1 , S100A4 , S100A6 . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| Chromatographic procedures and amino acid sequence analysis were used in this study to identify seven calcium binding proteins , annexin 6 , cap g , annexin 5 , calmodulin , S100A11 , S100B and S100A6 , associated with uveal melanoma , the primary ocular tumor of adults . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| Recently , NMR spectroscopy has provided the three dimensional structures of the S 100 family members S100A6 and S100B in both the apo and calcium bound forms . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| The levels of expression of the S100A1 , S100A2 , S100A3 , S100A4 , S100A5 , S100A6 and S100B proteins were immunohistochemically assayed and quantitatively determined in a series of 95 astrocytic tumors including 26 World Health Organization ( WHO ) grade 1 ( pilocytic astrocytomas ) , 23 WHO grade 2 ( astrocytomas ) , 25 WHO grade 3 ( anaplastic astrocytomas ) and 21 WHO grade 4 ( glioblastomas ) cases . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| Despite the numerous putative functions of S 100 proteins , their three dimensional structures of , e . g . , S100B , S100A6 , and S100A7 are surprisingly similar . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| This chapter will focus on the S100B and S100A6 proteins , which are highly expressed in the central nervous system . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| Differential expression of S100B and S100A6 ( 1 ) in the human fetal and aged cerebral cortex . ^^^ S100B and S100A6 ( calcylin ) are two members of the S 100 Ca ( 2+ ) binding protein family and have been localized in the mammalian nervous system . ^^^ In the present study , an immunocytochemical method was used to examine the spatio temporal protein expression patterns of S100B and S100A6 in normal human fetal hippocampus , entorhinal cortex and occipital cortex . ^^^ S100A6 positive cells were on the whole fewer in number than those of S100B in the brain regions examined . ^^^ The differential spatio temporal expression of S100B and S100A6 proteins suggests that the proteins play different roles in different brain regions during development and in adulthood . . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| A . , we investigated , by immunohistochemistry , the presence of different S 100 proteins ( S100A1 , S100A2 , S100A3 , S100A4 , S100A5 , S100A6 , S100A8 , S100A9 , S100A12 and S100B ) in C . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| METHODS : Formalin fixed , paraffin embedded tissues from fibrous papules ( FP , 20 ) , dermatofibromas ( DF , 20 ) , dermatofibrosarcoma protuberans ( DFSP , 5 ) , atypical fibroxanthomas ( AFX , 5 ) , oral fibromas ( 3 ) , digital fibroma ( 1 ) , and dermatomyofibroma ( 1 ) were evaluated with antibodies to S100A6 , S100B , factor XIIIa , and MAC 387 using a one hour capillary action based immunohistochemical procedure . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| METHODS : Formalin fixed , paraffin embedded archival tissues were evaluated by immunohistochemistry using antibodies specific for S100A6 and S100B in 38 intradermal nevi ( IDN ) . ^^^ Both GCT were negative with anti S100A6 but positive with anti S100B . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| The expression levels of seven different S 100 proteins ( S100A1 , S100A2 , S100A3 , S100A4 , S100A5 , S100A6 , and S100B ) were characterized by immunohistochemistry in the epithelial versus connective tissues of a series of 35 colon specimens , including 6 normal samples , 5 adenomas with low grade dysplasia , 5 adenomas with high grade dysplasia , and 19 cancers . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| The protein is found to possess essentially the same secondary structure found in other S 100 proteins such as S100A6 and S100B . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| Using a nitrocellulose overlay assay with 125I CacyBP / SIP and CacyBP / SIP affinity chromatography , we found that this protein binds purified S100A1 , S100A6 , S100A12 , S100B , and S100P but not S100A4 , calbindin D ( 9k ) , parvalbumin , and calmodulin . ^^^ Co immunoprecipitation of CacyBP / SIP with S100B from brain and with S100A6 from Ehrlich ascites tumor cells suggests that these interactions are physiologically relevant and that the ubiquitinylation complex involving CacyBP / SIP might be regulated by S 100 proteins . . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| The overall apo S100A3 structure resembles the structures of metal free S100B and S100A6 solution structures . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| The results of this study suggest that the calcium binding proteins S100A1 , S100A4 , S100A6 and S100A10 , but not S100B , are expressed in guinea pig smooth muscle , and could be potentially involved in the regulation of cytoplasmic Ca ( 2+ ) concentration and / or in signal transduction in smooth muscle . . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| AIMS : To investigate whether epidermoid cysts , branchial cysts , craniopharyngiomas and cholesteatomas express S 100 proteins differentially by immunohistochemical assaying the presence of S100A1 , S100A2 , S100A3 , S100A4 , S100A5 , S100A6 and S100B . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| S100A6 and S100A11 are specific targets of the calcium and zinc binding S100B protein in vivo . ^^^ Using S100B as bait , we identify S100A6 and S100A11 as specific targets for S100B . ^^^ S100A1 , the closest homologue of S100B , is capable of interaction with S100B but does not interact with S100A6 or S100A11 . ^^^ S100B , S100A6 , and S100A11 isoforms are co regulated and co localized in astrocytoma U 373 cells . ^^^ Furthermore , co immunoprecipitation experiments demonstrated that Ca ( 2+ ) / Zn ( 2+ ) stabilizes S100B S100A6 and S100B S100A11 heterocomplexes . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| Sgt 1 binds not only to S100A6 but also to S100B and S100P , other members of the S 100 family . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| The results validated the expression of S100A4 , S100A6 , and S100B in specific tumor types . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| The fixed tumour material from each meningioma was submitted to histochemical analyses targeting galectin 3 and its binding sites , the S100A5 , S100A6 and S100B proteins , and cathepsin B and D . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| This pattern of distribution partially overlaps that of the previously studied S100B and S100A6 proteins , indicating a possible functional cooperation between these proteins . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| Fourteen S 100 protein genes are located within the epidermal differentiation complex on human chromosome 1q21 and 13 S 100 proteins ( S100A2 , S100A3 , S100A4 , S100A6 , S100A7 , S100A8 , S100A9 , S100A10 , S100A11 , S100A12 , S100A15 , S100B , and S100P ) are expressed in normal and / or diseased epidermis . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| Detection of S100B , S100A6 and galectin 3 ligands in meningiomas as markers of aggressiveness . ^^^ Using 63 meningiomas ( 39 benign and 24 atypical ) , we performed a semi quantitative histochemical analysis of both the expression of galectin 3 and its ligand profile and the Ca2+ binding proteins S100A5 , S100A6 and S100B . ^^^ Our results thus suggest that the galectin 3 binding sites and S100B ( and S100A6 to a lesser extent ) could play a role in the aggressiveness characterizing atypical meningiomas . . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| These S100A6 neocortex labelled astrocytes were also positive for the glial fibrillary acidic protein ( GFAP ) and S100B protein . ^^^ Contrasting with S100A6 , the distribution for S100B and GFA astrocytic labelled cells was not restricted to the Abeta amyloid deposit in grey matter , but widely distributed throughout the neocortex . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| Cotransfection of S100A6 in cultured neonatal rat cardiac myocytes inhibits induction of the cardiac fetal gene promoters skeletal alpha actin ( skACT ) and beta myosin heavy chain ( beta MHC ) by PDGF , PE , AII , and the prostaglandin F2alpha ( PGF2alpha ) , induction of the S100B promoter by PE , and induction of the alpha MHC promoter by triiodothyronine ( T 3 ) . ^^^ Fluorescence microscopy demonstrated overlapping intracellular distribution of S100B and S100A6 in transfected myocytes and in postinfarct myocardium but heterodimerization of the two proteins could not be detected by co immunoprecipitation . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : A custom made tissue array , containing 291 tissue cores representing 28 tissue types and 21 tumour types , was used to produce sections that were immunostained for S100A2 , S100A6 , S100A8 , S100A9 , S100A11 , calbindin 1 , calbindin 2 , S100B and parvalbumin . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| A total of ten S 100 family members are reported in the literature to be expressed in brain S100A1 , S100A2 , S100A4 , S100A5 , S100A6 , S100A10 , S100A11 , S100A13 , S100B , and S100Z . ^^^ In addition , there was a 100 fold range in the mRNA levels for the six family members that were detected in mouse brain : S100A1 / S100B levels were 5 fold higher than S100A6 / S100A10 levels and 100 fold higher than S100A4 / S100A13 levels . ^^^ Five of these six family members ( S1100A1 , S100A6 , S100A10 , S100A13 , and S100B ) exhibited age dependent increases in expression in adult mice that ranged from 5 to 20 fold . ^^^ |
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| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND / AIMS : The authors investigated the expression of S100A1 , S100A6 , S100B , MelanA , and CEA in conjunctival naevi , primary acquired melanosis ( PAM ) , conjunctival melanoma , and uveal melanoma in order to assess their potential usefulness in the pathological differential diagnosis of these entities . ^^^ METHODS : Paraffin embedded sections of 18 conjunctival naevi , 14 PAM , 16 conjunctival melanomas , and 20 uveal melanomas were immunostained for S100A1 , S100A6 , S100B , MelanA , and CEA , and expression was scored semiquantitatively . ^^^ |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06703 and P04271 |
Pubmed |
SVM Score :0.0 |
| NA |
|