| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.54270211 |
| We have previously demonstrated the non covalent association of the protein tyrosine kinases p56lck and p60fyn together with a number of substrates for phosphorylation with rat thymocyte Thy 1 . 0.54270211^^^ |
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| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| Our objective was to examine p 56 ( lck ) protein levels , flow cytometric markers of T cell development ( CD 4 , CD 8 , TCRalphabeta , TCRgammadelta and CD 90 ) and absolute cell numbers in thymus , spleen and blood of zinc deficient ( ZD ) , diet restricted ( DR ) and control ( CTL ) rats . ^^^ |
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| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| A protein tyrosine kinase associated with the GPI linked proteins CD 59 , CD 55 , and CD 48 in human T cells , and with Thy 1 in mouse T cells was identified as p56lck , a protein tyrosine kinase related to Src . ^^^ |
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| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| Along with the aggregation of Thy 1 and CD 4 , nonreceptor protein tyrosine kinase p56lck was aggregated and activated . ^^^ |
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| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| Thus , lck is associated with CD 4 , CD 8 , and Thy 1 , whereas fyn is associated with the T cell antigen receptor and Thy 1 . ^^^ |
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| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| Large , detergent resistant complexes containing murine antigens Thy 1 and Ly 6 and protein tyrosine kinase p56lck . ^^^ Here we show that two murine antigens of this group , Thy 1 and Ly 6 , implicated in the activation of the T cells , are associated with each other , with the kinase p56lck and with several of potential kinase substrates in very large , detergent resistant complexes , the size of which is between 50 and 200 nm , as determined by ultrafiltration and gel chromatography . ^^^ |
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| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| Evidence was then provided that acceleration of the kinase activity of p56lck was involved in the CD3 / Thy 1 crosslinkage triggered signal . ^^^ |
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| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| The association of the protein tyrosine kinases p56lck and p60fyn with the glycosyl phosphatidylinositol anchored proteins Thy 1 and CD 48 in rat thymocytes is dependent on the state of cellular activation . ^^^ By immunoprecipitation from detergent lysates and in vitro immune complex kinase reactions the GPI anchored molecules Thy 1 and CD 48 are shown to be associated with multimolecular complexes of phosphoproteins including the protein tyrosine kinases p56lck and p60fyn in both rat and mouse thymocytes . ^^^ |
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| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| Here , we report that thymocytes from Thy 1 / mice [ 8 ] had altered cell cell contacts , and hyperresponsiveness to T cell receptor ( TCR ) triggering as demonstrated by the heightened activation of p56lck , phosphorylation of TCR subunits , Ca2+ fluxes and cell proliferation . ^^^ |
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| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| MBCD released substantial quantities of GPI anchored Thy 1 and glycosphingolipid GM 1 , and also other surface proteins including CD 45 , and intracellular Lck and Fyn kinases . ^^^ |
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| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| We show here that cross linking of PrPc with specific antibodies leads to 1 ) PrPc capping in Jurkat and human peripheral blood T cells ; 2 ) to cocapping with the intracellular lipid raft proteins reggie 1 and reggie 2 ; 3 ) to signal transduction as seen by MAP kinase phosphorylation and an elevation of the intracellular Ca2+ concentration ; 4 ) to the recruitment of Thy 1 , TCR / CD3 , fyn , lck and LAT into the cap along with local tyrosine phosphorylation and F actin polymerization , and later , internalization of PrPc together with the reggies into limp 2 positive lysosomes . ^^^ |
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| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| Thymic and splenic cell numbers as well as CD4 / CD8 cellularity were normal in lck FLIP ( S ) transgenic animals , which in contrast to CD 95 deficient mice do not accumulate Thy 1 ( + ) B 220 ( + ) CD 4 ( ) CD 8 ( ) peripheral T cells . c FLIP ( S ) overexpression leads to a significant decrease in activation induced T cell proliferation in vitro . ^^^ |
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| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04216 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|