| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| By heterodimerizing with its partner MAX , MYCN could bind to multiple DNA fragments within the 1 , 600 bp . ^^^ |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| The N myc oncoprotein is a transcriptional activator and associates with max and RB 1 proteins . ^^^ |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| Nmi interacts with c Myc , N Myc , Max , and fos , as demonstrated by yeast two hybrid and coimmunoprecipitation assays . ^^^ |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| The mycN / max protein complex in neuroblastoma . ^^^ As a consequence of amplification , elevated levels of the mycN protein are expressed . mycN contains a C terminal basic region ( BR ) that can bind to DNA , and a helix loop helix ( HLH ) leucine zipper ( Zip ) domain , which is responsible for the physical interaction with another HLH Zip protein , max . ^^^ The mycN protein , but not max , contains , near the N terminus , a region conferring the ability to activate the transcription of genes . mycN / max heterodimers probably activate and max / max homodimers repress transcription of , as yet , unidentified target genes . ^^^ |
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| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| Pleiotropic over expression of multidrug resistance related genes is correlated to MYCN and max mRNA accumulation during tumour progression in the IGR N 91 human neuroblastoma model . ^^^ Molecular analysis of tumour materials revealed a significant increase in MYCN and max gene transcript levels in the haemorrhagic area , as compared with the pearly and vascularized areas . ^^^ In this area of the tumours , multidrug resistance related genes , i . e . , MDRI , MRP , GST pi and topoisomerase 2 alpha were activated concomitantly with MYCN and max genes . ^^^ |
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| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| Both Max and Nmi also bind to MycN . ^^^ In contrast to the well defined binding of Max to Myc family proteins the interaction of Nmi with Myc or MycN is only poorly characterized . ^^^ |
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| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| MYCN is a member of the myc family of proto oncogenes which encode nuclear proteins that form heterodimers with MAX protein through their conserved HLHZip domains . ^^^ |
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| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| Employing co immunoprecipitation with either anti Myc or anti Max antibodies , we show that the transfected normal c Myc , N Myc , and L Myc oncoproteins associate with the endogenous Max protein in REF transformants , indicating that the Max interaction represents at least one component common to Myc family function . ^^^ |
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| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| The N Myc oncoprotein is associated in vivo with the phosphoprotein Max ( p20 / 22 ) in human neuroblastoma cells . ^^^ While the expression of N myc is restricted , expression of both Max ( p20 / 22 ) and the murine homolog Myn ( p20 / 22 ) was observed in cells of diverse human and murine embryonal lineages as detected by heterologous complex formation . ^^^ |
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| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| Max specifically associated with c Myc , N Myc , and L Myc proteins , but not with a number of other bHLH , bZip , or bHLH Zip proteins . ^^^ |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| Lack of correlation between N myc and MAX expression in neuroblastoma tumors and in cell lines : implication for N myc MAX complex formation . ^^^ MAX mRNA levels were independent of tumor stage and N myc genomic amplification . ^^^ Immunoprecipitations with a specific antibody to MAX detected two proteins of M ( r ) 21 , 000 and 22 , 000 in approximately equal amounts in all neuroblastoma lines regardless of N myc amplification and / or expression . ^^^ Thus , N myc expression might be a limiting factor in the formation of the N myc MAX heterodimer in neuroblastomas . . ^^^ |
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| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| We analysed the expression of c myc , N myc , L myc , max and RB 1 mRNAs in a panel of human gliomas and glioma cell lines and compared the findings with normal neural cells . ^^^ |
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| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| Differential patterns of DNA binding by myc and max proteins . c myc , N myc , and L myc genes are subject to highly variable degrees of tissue specific regulation . ^^^ |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| N Myc , like c Myc , preferentially forms heterodimeric DNA binding complexes with Max protein . ^^^ Mutational analyses of N Myc basic region ( BR ) , helix loop helix ( HLH ) and leucine zipper ( LZ ) regions revealed that all three regions are necessary for DNA binding by N Myc Max complexes , and that dimerization requires both HLH and LZ motifs , while BR sequences are needed only for DNA binding . ^^^ |
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| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| These data support the hypothesis that N Myc affects neuroblastoma gene expression through the formation of a DNA binding heterodimeric complex with Max in vivo . . ^^^ |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| Retinoic acid induced growth arrest and differentiation of neuroblastoma cells are counteracted by N myc and enhanced by max overexpressions . ^^^ Since N Myc functions appear to be mediated by heterodimerization with Max , the ectopic overexpression of max in NB cells was also investigated . ^^^ In contrast to N Myc , Max strongly induced the differentiation by enhancing the effects of RA . ^^^ These findings suggest that the relative levels of N Myc compared to Max appears to be crucial in stimulating neuroblastoma growth or differentiation , and may contribute to explain the remarkable clinical behaviour of neuroblastomas . . ^^^ |
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| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| The immunoaffinity purified N Myc , Max , Mad , and , presumably , c Myc were highly phosphorylated , and phosphatase treatment increased the DNA binding activity of Myc , suggesting that the DNA binding activity of c Myc was regulated by phosphorylation in vivo . ^^^ |
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| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| In in vitro protein : protein association assays , dMax interacted with c Myc , N Myc , L Myc , Mad 1 , Mxi 1 , Mad 3 and Mad 4 , but not with itself or wild type Max . ^^^ |
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| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| METHODS : Expression of the c myc , N myc , and L myc proto oncogenes and of the max gene was investigated in 46 supratentorial glioblastomas from adult patients using in situ hybridization . ^^^ RESULTS : Seventy eight percent of the tumors expressed c myc m RNA , 84 % max m RNA , 57 % N myc m RNA , and 57 % L myc m RNA . ^^^ |
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| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| The Ndr 1 promoter activity was down regulated by N myc , and more strongly by the combination of N myc and Max in the cotransfection assay . ^^^ This repressive effect was mediated by the promoter region within 52 base pairs from the transcription start site but direct binding of N myc : Max to the promoter sequence was not demonstrated , which is analogous to the cases recently reported for transcriptional repression by c myc . c myc also repressed Ndr 1 promoter activity similarly to N myc . ^^^ The effect of N myc : Max was sensitive to Trichostatin A , indicating involvement of histone deacetylase activity in repression of the Ndr 1 promoter . ^^^ |
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| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To examine the expression of myc proto oncogenes ; c myc , L myc , and N myc , and their related genes max and mad , in the arthritic synovium . ^^^ RESULTS : As a novel finding , synovial cells were observed to express L myc , N myc as well as their related genes max and mad , in addition to the previously described presence of c myc proto oncogene in synovium . c myc , L myc , N myc , and mad were expressed in all patient samples studied , including the controls . ^^^ CONCLUSIONS : The L myc , N myc , max , and mad genes are expressed in synovial cells , in addition to c myc proto oncogene . ^^^ |
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| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| Nmi was initially identified through a yeast two hybrid interaction with N Myc but it also interacts with c Myc , Max , Fos , and several other transcription factors , including signal transducer and activator of transcription ( Stat ) proteins . ^^^ |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| However , the amount of max bound to the promoters was high before and after induction of N myc . ^^^ Therefore , our studies suggest that N myc competes with other max partners for binding to target promoters . ^^^ |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| From a family of 73 H 1 motifs belonging to ( H 1 Loop H 2 ) hu man sequences , the smallest evolutionary distance from our reference peptide was observed for the H 1 of N Myc , L Myc , c Myc , H 1 S6A , F8A of c Myc , and Max , in that order . ^^^ |
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| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| N Myc is a transcription factor that forms heterodimers with the protein Max and binds gene promoters by recognizing a DNA sequence , CACGTG , called E box . ^^^ |
|
| Interacting proteins: P04198 and P61244 |
Pubmed |
SVM Score :0.0 |
| Here we summarize the findings obtained from the myc / max / mad knockout mice generated to date , namely those in which the N myc , c myc , L myc , mad 1 , mxi 1 , mad 3 , mnt , or max genes have been targeted . ^^^ |
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