| Interacting proteins: P04156 and P31948 |
Pubmed |
SVM Score :0.77136333 |
| Recombinant STI 1 ( His 6 STI1 ) added to hippocampal cultures interacts with PrPc at the neuronal surface and elicits neuritogenesis in wild type neurons but not in PrPc null cells . 0.77136333^^^ |
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| Interacting proteins: P04156 and P31948 |
Pubmed |
SVM Score :0.0 |
| The interaction sites were mapped to amino acids 113 128 from PrP ( c ) and 230 245 from STI 1 . ^^^ Cell surface binding and pull down experiments showed that recombinant PrP ( c ) binds to cellular STI 1 , and co immunoprecipitation assays strongly suggest that both proteins are associated in vivo . ^^^ Moreover , PrP ( c ) interaction with either STI 1 or with the peptide we found that represents the binding domain in STI 1 induce neuroprotective signals that rescue cells from apoptosis . . ^^^ |
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| Interacting proteins: P04156 and P31948 |
Pubmed |
SVM Score :0.0 |
| PrP cooperates with STI 1 to regulate SOD activity in PrP deficient neuronal cell line . ^^^ In the present study , elucidation of the mechanisms by which PrP ( C ) elicits the anti oxidative activities was facilitated by evidence of stress inducible protein 1 ( STI 1 ) mediating PrP ( C ) dependent superoxide dismutase ( SOD ) activation . ^^^ Immunoprecipitation revealed that PrP ( C ) was associated with STI 1 . ^^^ The inhibitory peptides against PrP ( C ) STI 1 binding [ STI 1 pep . 1 and PrP ( 113 132 ) ] indicated toxic activity in PrP ( C ) expressing cells by inhibiting SOD activity but not in Prnp ( / ) cells . ^^^ Furthermore , OR and N terminal half of the HR were required for the inhibitory effect of PrP ( 113 132 ) but not STI 1 pep . 1 . ^^^ |
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