| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| Since clusterin ( apolipoprotein J ) mRNA levels are increased in prion related encephalopathies and clusterin immunoreactivity has been located in association with PrPSc in Gerstmann Strussler Scheinker brain , the expression of clusterin was determined in neuronal and astroglial cells chronically exposed to PrP 106 126 . ^^^ |
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| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| PrP accumulation was immunohistochemically demonstrated in autophagic vacuoles in degenerated muscle fibers , and this was accompanied by the accumulation of other molecules related to the neuropathogenesis of prion diseases such as clathrin , cathepsin B , heparan sulfate , and apolipoprotein J . ^^^ |
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| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| Clusterin ( apolipoprotein J ) has been recognized as one of the molecules associated with PrP in TSEs , and clusterin expression is increased in the central nervous system where abnormal PrP deposition has occurred . ^^^ |
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| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| The dorsal horns of the spinal cord in which BSE prion protein ( PrP ( BSE ) ) was deposited did not exhibit strong clusterin `` up regulation ' ' but showed increased clusterin immunolabelling with a punctate distribution in the neuropil . ^^^ Labelling of adjacent sections of the grey matter in BSE affected spinal cord and thalamus demonstrated that the clusterin was deposited in association with extracellular PrP ( BSE ) . . ^^^ |
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| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| Clusterin immunoreactivity was co localized with plaque type deposits but not with punctate type prion protein ( PrP ) deposits in human TSEs . ^^^ On the other hand , clusterin positive astrocytes were readily demonstrated in the regions of punctate PrP deposits , but not around plaque PrP deposits despite the presence of surrounding astrocytes . ^^^ Clusterin expression in astrocytes was not disease specific , but the punctate immunoreactivity for clusterin was more prominently demonstrated in TSEs with punctate PrP deposits . ^^^ Serial analysis in the mouse model of human TSE revealed that clusterin expression in astrocytes was enhanced in the lesions with punctate type PrP deposits during the disease progression . ^^^ Thus , the induction of clusterin expression in astrocytes could be more enhanced by punctate type PrP deposits than by plaque type deposits . ^^^ |
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| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| In addition , clusterin co localizes in PrPRES plaques in several human TSEs , including Creutzfeldt Jakob disease ( CJD ) . ^^^ Clusterin is up regulated in the cerebral cortex and cerebellum in CJD as revealed by DNA micro array technology . ^^^ Clusterin expression was examined in seven sporadic cases of CJD ( codon 129 genotype , PrP type : 4 MM 1 , 1 MV 1 , 1 MV 2 , 1 VV 2 ) and three age matched controls by immunohistochemistry , Western blotting and solubility . ^^^ Clusterin in CJD , but not clusterin in control brains , was partially resistant to protease digestion in Western blots of total brain homogenates immunostained with anti clusterin antibodies , which were processed in parallel with Western blots to PrP , without and with pre incubation with proteinase K . ^^^ Clusterin was recovered in the cytosolic , deoxycholate and SDS fraction in both CJD and control cases , but only clusterin from CJD was recovered in the urea soluble fraction and , especially , in the remaining pellet . ^^^ |
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| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| Clusterin is a multiple function protein which participates in Abeta amyloid , PrP ( res ) and a synuclein aggregation in Alzheimer disease , prionopathies and a synucleinopathies , respectively . gamma Tubulin is present in the centrosome and is an intracellular marker of the aggresome . ^^^ |
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| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| With the exception of bcl 2 mRNA decrease and a slight increase of SGP 2 in PrP 106 126 treated cells , no consistent alterations of these mRNA expressions were found in neuronal cells exposed to beta 25 35 or PrP 106 126 . ^^^ |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10909 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|