| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| Both apoE epsilon 4 and PRNP Val allelic effects were additive . ^^^ |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| We analyzed apolipoprotein E ( apo E ) genotypes in 53 Japanese sporadic Creutzfeldt Jakob disease ( CJD ) patients and 100 normal controls using the polymerase chain reaction ( PCR ) and restriction fragment length polymorphism ( RFLP ) methods . ^^^ The apo E allelic frequencies in Japanese sporadic CJD patients and our control population were as follows : epsilon 2 , 6 . 6 % versus 7 . 5 % ; epsilon 3 , 82 . 1 % versus 81 . 5 % ; epsilon 4 , 11 . 3 % versus 11 . 0 % . ^^^ These results indicate that there is no association between apo E genotype and sporadic CJD in Japan . . ^^^ |
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| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| We determined codon 129 of the prion gene and the Apo E variants in Creutzfeldt Jakob disease ( CJD ) using PCR and restriction digest . ^^^ We found a significant correlation between valine at codon 129 of the prion protein gene and the presence of plaque in CJD and a later age of onset in CJD cases possessing the Apo E 2 allele . ^^^ |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To analyze the distribution of apolipoprotein E ( Apo E ) phenotypes between patients with Creutzfeldt Jakob disease ( CJD ) and control subjects . ^^^ Patients with definite CJD had a mean ( SD ) Apo E concentration of 3 . 4 ( 2 . 0 ) mg / L ; patients with probable CJD , 3 . 1 ( 1 . 6 ) mg / L ; patients with possible CJD , 3 . 8 ( 2 . 2 ) mg / L ; and subjects with other diseases , 3 . 0 ( 1 . 7 ) mg / L . ^^^ CONCLUSIONS : We found no significant difference in the distribution of Apo E phenotypes between patients with CJD and controls . ^^^ The Apo E phenotype had no influence on the duration of CJD . ^^^ Our data do not support an association of Apo E 4 with either the duration or time at onset of CJD . . ^^^ |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| We assessed the apolipoprotein E ( ApoE ) genotype in 49 sporadic and ten familial Creutzfeldt Jakob disease ( CJD ) patients , in seven healthy siblings with a PRNP mutation and in 84 controls . ^^^ |
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| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| Interestingly , there was a significantly different ( P = 0 . 04 ) ACT distribution between CJD patients and controls in apolipoprotein E ( ApoE ) E 4 , and the interaction between ACT and ApoE was almost significant ( P = 0 . 053 ) . ^^^ |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| We investigated the risk associated with the codon 129 polymorphism in the prion protein gene ( PRNP ) and apolipoprotein E gene ( APOE ) isoforms for development of Creutzfeldt Jakob disease ( CJD ) ( n=126 ) and the possible influences on the disease pathology and its most important clinical characteristics . ^^^ |
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| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| Other genes specifically regulated by CSD were involved in oxidative stress responses ( major prion protein , glutathione S transferase 5 , and apolipoprotein E ) . ^^^ |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| From a series of 61 patients with CJD we found that epsilon 4 allele of the APOE gene was a risk factor for the disease ( p < 0 . 01 ) . ^^^ |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| We analyzed the sheep ApoE genotypic and the allelic frequencies in scrapie and control Suffolk sheep , but they did not significantly differ from those in the control sheep , even though PrP genotype matched populations were compared . ^^^ |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| METHODS : We examined the frequency of the APOE alleles in patients with various forms of transmissible spongiform encephalopathies , or prion diseases , including sporadic and iatrogenic Creutzfeldt Jakob disease ; familial Creutzfeldt Jakob disease associated with PRNP 178N / 129V and 200K / 129M point mutations and a 24 nucleotide repeat expansion ; fatal familial insomnia caused by the 178N / 129M mutation ; Gerstmann Strussler Scheinker disease associated with 102L / 129M mutation ; and kuru . ^^^ |
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| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| Immunocytochemically detectable apoE was restricted to compact plaque type PrP deposits after week 15 . ^^^ Immunocytochemically detectable apoE deposition follows PrP accumulation . . ^^^ |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| Additionally , APOE status was determined in patients with CJD . ^^^ Decreased levels of Abeta 1 42 did not correlate with the APOE epsilon 4 load in patients with CJD . ^^^ |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| In the present study we have compared the interaction of apoE with A beta , the gelsolin derived amyloid fragment AGel ( 183 210 ) and the amyloidogenic prion fragments PrP ( 109 122 ) and PrP ( 109 141 ) . ^^^ We show that , similar to A beta , also AGel and PrP fragments can form a complex with apoE , and that the interaction between apoE and the amyloidogenic protein fragments is mediated through the same binding site on apoE . ^^^ We also show that apoE increases the thioflavin T fluorescence of PrP and AGel and that apoE influences the content of beta sheet conformation of these amyloidogenic fragments . ^^^ |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| Analyses stratifying by APOE genotype , age , and gender failed to reveal any association between homozygosity for the 129 PRNP methionine or valine alleles and AD . . ^^^ |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| These immunohistochemical characteristics indicated that apoE colocalization occurred in moderate mature lesions in PDs , and apoE might play an important role in the aggregation of PrPsc after a conformational change from cellular PrP isoform to PrPsc . . ^^^ |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| Structural genomics studies with AD related genes , including APP , MAPT , APOE , PS 1 , PS 2 , A2M , ACE , AGT , cFOS and PRNP genes , demonstrate different genetic profiles in AD and DVC , with an absolute genetic variation rate ranging from 30 to 80 % , depending upon genes and genetic clusters . ^^^ |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| Structural genomic studies with AD related genes , including APP , MAPT , APOE , PS 1 , PS 2 , A2M , ACE , AGT , cFOS , and PRNP , demonstrate different genetic profiles in AD and DVC , with an absolute genetic variation rate in the range of 30 80 % , depending upon genes and genetic clusters . ^^^ |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02649 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
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