| Interacting proteins: Q6W4X9 and P04155 |
Pubmed |
SVM Score :0.0 |
| We show that TFF 1 co elutes with MUC5AC but not MUC 6 on gel filtration and that immunoprecipitation and Western transfer analysis confirms that TFF 1 interacts with MUC5AC . ^^^ |
|
| Interacting proteins: Q6W4X9 and P04155 |
Pubmed |
SVM Score :0.0 |
| In this analysis , a cluster of extrapancreatic foregut markers , including pepsinogen C , MUC 6 , KLF 4 , and TFF 1 , was found to be up regulated in PanIN . ^^^ |
|
| Interacting proteins: Q6W4X9 and P04155 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry was performed for secretory mucins ( MUC5AC , MUC5B , MUC 6 ) , Trefoil factor family ( TFF ) peptides ( TFF 1 , TFF 2 ) , endocrine peptides ( gastrin , chromogranin A ) , and proliferating cells ( Ki 67 ) . ^^^ Infection was correlated with decreased MUC5AC , TFF 1 , and TFF 2 expression and increased MUC 6 and MUC5B expression . ^^^ |
|
| Interacting proteins: Q6W4X9 and P04155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6W4X9 and P04155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q6W4X9 and P04155 |
Pubmed |
SVM Score :0.0 |
| The expression of two trefoil peptides ( TFF 1 and TFF 2 ) and four mucins ( MUC 1 , MUC 2 , MUC5AC , and MUC 6 ) was evaluated by immunohistochemistry and reverse transcription polymerase chain reaction ( RT PCR ) in 29 gastric polyps , 10 hyperplastic and 19 adenomatous , eight of which displayed malignant transformation . ^^^ |
|
| Interacting proteins: Q6W4X9 and P04155 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry was performed for secretory mucins ( MUC 2 , MUC5AC , MUC5B , MUC 6 ) , TFFs ( TFF 1 , TFF 2 , TFF 3 ) , and proliferation ( Ki 67 ) . ^^^ MUC5AC and TFF 1 showed high levels and strong colocalization in the surface epithelium , whereas MUC 6 , MUC5B and TFF 3 were found in the deeper glandular structures . ^^^ |
|
| Interacting proteins: Q6W4X9 and P04155 |
Pubmed |
SVM Score :0.0 |
| Adenocarcinomas ( 14 duodenal , 10 gastric , 11 ampullary and 10 colorectal ) were examined immunohistochemically for the mucin gene products MUC 1 , MUC 2 , MUC5AC , MUC 6 and the trefoil peptides TFF 1 and TFF 2 . ^^^ The tumors ' expression profile for MUC5AC , MUC 6 and TFF 1 was used to distinguish between gastric and intestinal directed differentiation . ^^^ Further classification focusing on the expression profile for MUC5AC , MUC 6 and TFF 1 revealed that 21 % of the duodenal and 45 % of the ampullary carcinomas demonstrated mainly gastric differentiation ( positivity for all three markers or only two of them ) . ^^^ Among the markers used , MUC5AC , MUC 6 and TFF 1 are most useful for revealing differentiation pathways in duodenal and ampullary carcinoma . . ^^^ |
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| Interacting proteins: Q6W4X9 and P04155 |
Pubmed |
SVM Score :0.0 |
| Gastric carcinoma exhibits distinct types of cell differentiation : an immunohistochemical study of trefoil peptides ( TFF 1 and TFF 2 ) and mucins ( MUC 1 , MUC 2 , MUC5AC , and MUC 6 ) . ^^^ The expression of trefoil peptides ( TFF 1 and TFF 2 ) and mucins ( MUC 1 , MUC 2 , MUC5AC , and MUC 6 ) has previously been described in gastric polyps . ^^^ |
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| Interacting proteins: Q6W4X9 and P04155 |
Pubmed |
SVM Score :0.0 |
| RESULTS : MUC5AC and TFF 1 were colocalised in distal ductular and surface elements of the UACL and in foveolar cells of the stomach , whereas MUC 6 and TFF 2 were colocalised to acinar and proximal ductular structures in the UACL , in the fundus and deep antral glands of the stomach , and in Brunner ' s glands of the duodenum . ^^^ |
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| Interacting proteins: Q6W4X9 and P04155 |
Pubmed |
SVM Score :0.0 |
| Barrett ' s esophagus is characterized by expression of gastric type mucins ( MUC5AC , MUC 6 ) and TFF peptides ( TFF 1 and TFF 2 ) , but the risk of carcinoma development may be indicated by the intestinal type mucin , MUC 2 . ^^^ Sections were stained by immunohistochemistry for secretory mucins ( MUC 2 , MUC5AC , MUC5B , and MUC 6 ) , the proliferation marker Ki 67 , and mucin associated trefoil factor family ( TFF ) peptides ( TFF 1 , TFF 2 , and TFF 3 ) . ^^^ Ulcerating BE was distinguished by very low expression of MUC 6 and MUC5B , but very high expression of TFF 1 . ^^^ We conclude that BE is best characterized by the specific expression of the gastric type markers , MUC5AC , MUC 6 , TFF 1 , and TFF 2 . ^^^ |
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| Interacting proteins: Q6W4X9 and P04155 |
Pubmed |
SVM Score :0.0 |
| Expression was examined immunohistochemically of secretory mucins ( MUC 2 , MUC5AC , MUC5B , and MUC 6 ) , trefoil peptides ( TFF 1 , TFF 2 , and TFF 3 ) , and sucrase isomaltase ( SI ) . ^^^ TFF 1 , TFF 2 , and MUC 6 were found in 84 % , 92 % , and 65 % of GMD , respectively . ^^^ GMD was characterized by the expression of gastric type proteins MUC5AC , MUC 6 , TFF 1 , and TFF 2 and the absence of intestinal markers MUC 2 , TFF 3 , and SI . ^^^ |
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