| Interacting proteins: Q99933 and P04150 |
Pubmed |
SVM Score :0.0 |
| BAG 1 , a shorter isoform with only a duplication of the [ EEX ( 4 ) ] sequence , does not inhibit GR activity . ^^^ |
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| Interacting proteins: Q99933 and P04150 |
Pubmed |
SVM Score :0.0 |
| Differential effects of the hsp 70 binding protein BAG 1 on glucocorticoid receptor folding by the hsp 90 based chaperone machinery . ^^^ Inasmuch as BAG 1 has been found in association with several members of the steroid receptor family , we have examined the effect of BAG 1 on GR folding and GR . hsp90 heterocomplex assembly . ^^^ BAG 1 was present in reticulocyte lysate at a BAG 1 : hsp70 / hsc70 molar ratio of approximately 0 . 03 , and its elimination by immunoadsorption did not affect GR folding and GR . hsp 90 heterocomplex assembly . ^^^ At low BAG 1 : hsp70 / hsc70 ratios , BAG 1 promoted the release of Hop from the hsp 90 based chaperone system without inhibiting GR . hsp90 heterocomplex assembly . ^^^ However , at molar ratios approaching stoichiometry with hsp 70 , BAG 1 produced a concentration dependent inhibition of GR folding to the steroid binding form with corresponding inhibition of GR . hsp90 heterocomplex assembly by the minimal five protein chaperone system . ^^^ |
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| Interacting proteins: Q99933 and P04150 |
Pubmed |
SVM Score :0.0 |
| Hip does not affect glucocorticoid receptor folding by the hsp 90 based chaperone machinery except to oppose the effect of BAG 1 . ^^^ |
|
| Interacting proteins: Q99933 and P04150 |
Pubmed |
SVM Score :0.0 |
| Available data on the negative regulation of glucocorticoid receptor ( GR ) action by the BAG 1 proteins identify two modes of action : inhibition of the hormone binding activity of the GR and a more direct nuclear action at the level of regulation of the transactivation function of the receptor . ^^^ In the latter case , the BAG 1 proteins repress DNA binding by the GR in a process that requires prior binding of Hsp70 / Hsc70 to the receptor . ^^^ |
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| Interacting proteins: Q99933 and P04150 |
Pubmed |
SVM Score :0.0 |
| Essential role of the unusual DNA binding motif of BAG 1 for inhibition of the glucocorticoid receptor . ^^^ The co chaperone BAG 1 is involved in the regulation of steroid hormone receptors , including the glucocorticoid receptor ( GR ) . ^^^ More recently , BAG 1 was found in the nucleus where it decreases GR transactivation . ^^^ Surprisingly , this small , nonsequence specific DNA binding domain was nonetheless necessary for the inhibitory function of BAG 1 for GR dependent transcription , whereas the following serine and threonine rich E ( 2 ) 10 ( 4 ) repeat domain was not . ^^^ |
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| Interacting proteins: Q99933 and P04150 |
Pubmed |
SVM Score :0.0 |
| Subsequent analysis of brain tissues revealed NBI 30775 induced increases in the nuclear translocation of glucocorticoid receptors ( GR ) and BAG 1 , an upregulation of mRNA transcripts encoding GR , mineralocorticoid receptors ( MR ) and CRH R 1 , and a suppression of the DNA binding activity of the transcription factor AP 1 . ^^^ Molecules such as GR , MR , BAG 1 and AP 1 have been identified as some of the drug ' s intracellular targets ; interestingly , changes in these molecules have also been seen in response to conventional antidepressants , showing that structurally and mechanistically unrelated anxiolytic and antidepressant drugs can influence common downstream pathways . . ^^^ |
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| Interacting proteins: Q99933 and P04150 |
Pubmed |
SVM Score :0.0 |
| To induce apoptosis , GC bind to the GC receptor ( GR ) , which is regulated by various ( co ) chaperone proteins such as heat shock protein 70 ( HSP 70 ) , HSP 40 , HIP ( HSP 70 interacting protein ) , BAG 1 ( BCL 2 associated gene product 1 ) , HOP ( HSP 70 / HSP 90 Organizing protein ) , HSP 90 , P 23 , FKBP 51 , FKBP 52 and CYP 40 . ^^^ |
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| Interacting proteins: Q99933 and P04150 |
Pubmed |
SVM Score :0.0 |
| The anti apoptotic , glucocorticoid receptor cochaperone protein BAG 1 is a long term target for the actions of mood stabilizers . ^^^ Because BAG 1 attenuates glucocorticoid receptor ( GR ) nuclear translocation , activates ERK ( extracellular signal regulated kinase ) MAP ( mitogen activated protein ) kinases , and potentiates anti apoptotic functions of BCL 2 , extensive additional studies were undertaken . ^^^ Furthermore , small interfering RNA studies showed that these inhibitory effects on GR activity were mediated , at least in part , through BAG 1 . ^^^ Additionally , these studies suggest that regulation of GR mediated plasticity may play a role in the treatment of bipolar disorder and raise the possibility that agents affecting BAG 1 more directly may represent novel therapies for this devastating illness . . ^^^ |
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| Interacting proteins: Q99933 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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