| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.63314623 |
| The glucocorticoid receptor ( GR ) interacts with several coactivators , including steroid receptor coactivator 1 ( SRC 1 ) family and CREB binding protein ( CBP ) . 0.63314623^^^ |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :1.031043 |
| However , CBP does not physically interact with antagonist bound GR and does not enhance its repressive effect on p 65 . 1.031043^^^ |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.58738264 |
| Furthermore , we show that GR acts both as a direct inhibitor of CREB binding protein ( CBP ) associated HAT activity and also by recruiting HDAC 2 to the p 65 CBP HAT complex . 0.58738264^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| We have previously demonstrated the presence of a corticosteroid binding protein ( CBP ) in Candida albicans and speculated on its homology to the glucocorticoid receptor . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Here , we investigated the role of p300 / CBP ( CREB binding protein ) , a transcriptional coactivator of several groups of transcription factors , in Stat 5 mediated transactivation and in the cross talk between Stat 5 and the glucocorticoid receptor . p300 / CBP acts as a coactivator of Stat 5 . ^^^ Coimmunoprecipitation and mammalian two hybrid assays demonstrate a direct interaction between the carboxyl terminal transactivation domain of Stat 5 and p300 / CBP . p300 / CBP also positively interacts with the glucocorticoid receptor and enhances glucocorticoid receptor dependent transcriptional activation of the mouse mammary tumor virus long terminal repeat promoter . ^^^ Overexpression of p300 / CBP does not counteract the Stat 5 mediated inhibition of glucocorticoid receptor dependent transactivation , i . e . the repression of the glucocorticoid response by Stat 5 is not a consequence of competition for limiting amounts of p300 / CBP . . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Nuclear integration of glucocorticoid receptor and nuclear factor kappaB signaling by CREB binding protein and steroid receptor coactivator 1 . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Finally , the inhibition of class 2 gene expression by the glucocorticoid hormone could be attributed to the squelching of CBP by the glucocorticoid receptor . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Conditional modulation of glucocorticoid receptor activities by CREB binding protein ( CBP ) and p 300 . ^^^ Here , we show that one of the major coactivators of the glucocorticoid receptor ( GR ) , CREB binding protein ( CBP ) , can also function conditionally as a negative regulator of its activities . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Src potentiates activation functions in CREB binding protein ( CBP ) and glucocorticoid receptor interacting protein 1 ( GRIP 1 ) , and we discuss the possibility that the Src / JNK pathway enhances the activity of these coactivators , which are known to mediate AF 1 action . . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| In addition to PML protein , nuclear bodies contained SUMO 1 and the transcriptional regulators CREB binding protein ( CBP ) and glucocorticoid receptor ( GR ) . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| CHO K 1 cells transfected with ERalpha or ERbeta show ERE sequence dependent differences in the functional interaction of ERalpha and ERbeta with coactivators steroid receptor coactivator 1 ( SRC 1 ) , SRC 2 ( glucocorticoid receptor interacting protein 1 ( GRIP 1 ) ) , SRC 3 amplified in breast cancer 1 ( AIB 1 ) and ACTR , cyclic AMP binding protein ( CBP ) , and steroid receptor RNA activator ( SRA ) , corepressors nuclear receptor co repressor ( NCoR ) and silencing mediator for retinoid and thyroid hormone receptors ( SMRT ) , and secondary coactivators coactivator associated arginine methyltransferase 1 ( CARM 1 ) and protein arginine methyltransferase 1 ( PRMT 1 ) . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| The functional synergy of the p 160 coactivators [ steroid receptor coactivator 1 , glucocorticoid receptor interacting protein ( GRIP 1 ) , or the activator for thyroid hormone and retinoid receptors ] , the histone acetyltransferases cAMP response element binding protein binding protein ( CBP ) and p 300 and the histone methyltransferase coactivator associated arginine methyltransferase ( CARM 1 ) depends on the methyltransferase activity of CARM 1 . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| We have also shown that TBP , Ada 2 , and CBP can interact with both the tau 1 core and the GR ligand binding domain , offering a possible mechanism for synergistic interaction between the tau 1 core and other receptor activation domains . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Candidate factors have been identified by the observation that changes in glucocorticoid induction parameters in CV 1 cells could be reproduced by varying the cellular levels of coactivators [ transcriptional intermediary factor 2 ( TIF 2 ) , steroid receptor coactivator 1 ( SRC 1 ) , and amplified in breast cancer 1 ( AIB 1 ) ] , comodulator [ CREB binding protein ( CBP ) ] , or corepressor [ silencing mediator for retinoid and thyroid hormone receptors ( SMRT ) ] without concomitant increases in GR . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that neither the expression levels of p 65 and CBP nor their physical association are affected by activated GR . ^^^ In addition , the transactivation potential of a point mutated Gal 4 p65 variant with a decreased CBP interaction capability is still repressed by GR . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Furthermore , using cotransfection and antisense technology we have found that , unlike SRC 1 and GRIP 1 , which are not involved in the GR complex that suppresses keratin genes , histone acetyltransferase and CBP are . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Finally , GR competed with transcription factors for nuclear coactivators ( competition model ) , including CBP and p 300 . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Both factors make use of the coactivator cAMP response element binding protein ( CREB ) binding protein ( CBP ) to enhance their transcriptional activities , which led to the hypothesis that a mutual antagonism between p 65 or c Jun and activated glucocorticoid receptor ( GR ) results from a limited amount of CBP . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Mammalian two hybrid experiments show that the minimum TIF 2 segment with modulatory activity ( TIF2 . 4 ) does not interact with p 300 , CREB binding protein , or PCAF , which also modulates GR activities . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Most of the activities of GMEB 2 , such as homo and heterooligomerization , binding to GR and to CBP , DNA binding , and modulation of the above GR transcriptional properties , require large regions of the protein . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Glucocorticosteroid stimulated gene transcription is mediated by the glucocorticosteroid receptor ( GR ) that recruits coactivators of the p 160 family , forming a docking platform for secondary coactivators , such as cAMP response element binding protein ( CREB ) binding protein ( CBP ) or its close homologue , p 300 . ^^^ We show that , although the CBP / p300 binding domain of steroid receptor coactivator 1 is crucial for GR transactivation , neither CBP nor p 300 enhanced GR transcriptional activation , as shown by overexpression and small interfering RNA ( siRNA ) knocking down experiments . ^^^ Functional and pull down assays showed that beta catenin may be the coactivator replacing CBP in the GR transcriptional complex . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Lastly , GR may compete with NF kappaB for nuclear coactivators , including CREB binding protein and p 300 , thereby reducing and inhibiting transcriptional activation by NF kappaB . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| These activities include , homooligomerization , heterooligomerization , DNA binding , binding to GR and the transcriptional cofactor CBP , and GR modulation . ^^^ |
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| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|