| Coactivator TIF1beta interacts with transcription factor C / EBPbeta and glucocorticoid receptor to induce alpha 1 acid glycoprotein gene expression . ^^^ In this report , we have identified a novel transcriptional intermediary factor , TIF1beta , which could enhance the transcription of the agp gene by the glucocorticoid receptor ( GR ) and C / EBPbeta . ^^^ Immunoprecipitation experiments showed that the interaction between GR and TIF1beta is ligand independent . ^^^ The overexpression of the TIF1beta gene enhances GR regulated expression in a ligand and glucocorticoid responsive element ( GRE ) dependent manner . ^^^ |