| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.91171546 |
| We report here that CaM can interact in a calcium dependent manner with the untransformed glucocorticoid receptor ( GR ) complex containing hsp 90 . 0.91171546^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| Several findings show that this CaM ER interaction is very specific : lack of this interaction has been observed in the presence of trifluoperazine , an inhibitor of protein binding to CaM ; the receptor binds neither Sepharose , nor parvalbumin Sepharose ; competition of interaction of [ 3H ] ER complex with CaM Sepharose is observed by cold ER complex ; rat liver glucocorticoid receptor does not bind to CaM Sepharose . ^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| Calmodulin did not stimulate phosphorylation of the glucocorticoid receptor beyond that obtained with calcium alone . ^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| Calmodulin antagonists competitively inhibit dexamethasone binding to the glucocorticoid receptor . ^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| In vivo evidence for the generation of a glucocorticoid receptor heat shock protein 90 complex incapable of binding hormone by the calmodulin antagonist phenoxybenzamine . ^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| It is now clear that GCs can directly regulate cell adhesion molecule ( CAM ) gene transactivation through the classical glucocorticoid receptor ( GR ) pathways . ^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| The localization and ontogenic changes of expression of the mRNA for Ca2+ / calmodulin dependent protein kinase of the cerebellar granule cell type or type 4 ( CaM kinase Gr or 4 ) in the rat brain were examined by in situ hybridization histochemistry . ^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| Ca2+ / calmodulin dependent protein kinase enriched in cerebellar granule cells ( CaM kinase Gr ) is a neuronal calmodulin dependent protein kinase whose purification and partial cloning from rat brain has been described . ^^^ The deduced amino acid sequence was confirmed by comparison with the peptide sequence from purified CaM kinase Gr . ^^^ Screening a genomic library with a portion of the cDNA for CaM kinase Gr allowed the isolation of a genomic clone that contained at least 9 kilobases ( kb ) of the gene for CaM kinase Gr . ^^^ Analysis of the sequence revealed that the coding sequences for calspermin were contained within the CaM kinase Gr gene and that alternative splicing of internal exons may lead to the formation of the two different proteins , CaM kinase Gr and calspermin . . ^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of a Ras related GTP binding protein , Rap 1b , by a neuronal Ca2+ / calmodulin dependent protein kinase , CaM kinase Gr . ^^^ A neuron specific Ca2+ / calmodulin dependent protein kinase , CaM kinase Gr , phosphorylates selectively a Ras related GTP binding protein ( Rap 1b ) that is enriched in brain tissue . ^^^ Both CaM kinase Gr and cAMP dependent protein kinase , but not CaM kinase 2 , phosphorylate identical or contiguous serine residues in Rap 1b . ^^^ The rate of phosphorylation of Rap 1b by CaM kinase Gr is enhanced following autophosphorylation of the protein kinase . ^^^ Other low molecular weight GTP binding proteins belonging to the Ras superfamily , including Rab 3A , Rap 2b , and c Ha ras p 21 , are not phosphorylated by CaM kinase Gr . ^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| The granule cell enriched Ca2+ / calmodulin dependent protein kinase ( CaM kinase Gr ) is a recently discovered neuron specific enzyme . ^^^ A possible role in synapsin 1 phosphorylation and in nuclear Ca2+ signaling was supported by immunochemical and ultrastructural examination of CaM kinase Gr distribution . ^^^ CaM kinase Gr immunoreactivity was present in the molecular and granule cell layers of the rat cerebellum . ^^^ Thus , CaM kinase Gr may mediate and coordinate Ca 2 ( + ) signaling within different subcellular compartments . . ^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| The chorioallantoic membrane ( CAM ) of chicken embryos was used in an assay for this response , and normal mammary glands and various mammary growths from GR mice , including plaques , hyperplasic alveolar nodules , and hormone dependent and hormone independent tumors were tested . ^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| Expression of a Ca2+ / calmodulin dependent protein kinase , CaM kinase Gr , in human T lymphocytes . ^^^ Ca2+ / calmodulin dependent protein kinase type Gr ( CaM kinase Gr ) is a Ca2+ / calmodulin dependent protein kinase which is enriched in the brain and thymus . ^^^ In this study , we examined the expression of CaM kinase Gr in human lymphocytes and the regulation of its catalytic activity by antigen receptor signaling . ^^^ CaM kinase Gr was found selectively expressed in T lymphocytes in a developmentally regulated manner . ^^^ CD3 contribute to the activation of CaM kinase Gr . ^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| Using the recently developed models of the galactic cosmic radiation ( GCR ) environment and the energy dependent radiation transport code , we have calculated the dose at 0 and 5 cm water depth ; using a computerized anatomical man ( CAM ) model , we have calculated the skin , eye and blood forming organ ( BFO ) doses as a function of aluminum shielding for various solar minima and maxima between 1954 and 1989 . ^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| Using the Langley Research Center galactic cosmic ray ( GCR ) transport computer code ( HZETRN ) and the computerized anatomical man ( CAM ) model , crew radiation levels inside manned spacecraft on interplanetary missions are estimated . ^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| Prephosphorylation of tau by A kinase , C kinase , or CK 2 ( but not by CK 1 , CaM kinase 2 or Gr kinase ) increased both the rate and extent of a subsequent phosphorylation catalyzed by GSK 3 by several fold . ^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| As suggested by a previous study , T cell receptor induced phosphorylation events may be mediated by the Ca2+ / CaM dependent protein kinase type Gr ( CaM kinase Gr ) . ^^^ The CaM kinase Gr is only expressed in certain lymphoid cell lines , and the present study shows that ionomycin induced phosphorylation of Op 18 Ser16 is restricted to cells expressing this protein kinase . ^^^ Finally , CaM kinase Gr dependent in vitro phosphorylation of a crude cellular extract reveals a striking preference of this protein kinase for Op 18 compared to other cellular substrates . ^^^ In conclusion , the results suggest that Ser 16 of Op 18 is a major cytosolic target for activated CaM kinase Gr . . ^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| CaM kinase Gr is a Ca2+ / calmodulin dependent protein kinase that is enriched in brain and thymus . ^^^ Treatment of autophosphorylated CaM kinase Gr with acid phosphatase fully dephosphorylated the enzyme and reversed the changes in electrophoretic migration of both polypeptides . ^^^ The actual site ( s ) of autophosphorylation was determined by the purification and amino acid sequencing of tryptic peptides from 32P labeled CaM kinase Gr . ^^^ The functional and structural studies on CaM kinase Gr autophosphorylation imply that the enzyme is comprised of two regulatory domains , one on either side of a catalytic domain , followed by a C terminal , putative association domain . ^^^ |
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| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|