| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| Multiple cis acting sequences to which nuclear proteins bind have been mapped , and transcription factors that can bind to these sequences have been identified ; these include C / EBP alpha , Sp 1 , USF , HNF 1 , CTF / NF1 , the glucocorticoid receptor , and RAR alpha . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| We present evidence that both purified C / EBP alpha and glucocorticoid receptor bind strongly to the APRE . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| Furthermore , in glucocorticoid receptor defective EDR 1 hepatoma cells , dexamethasone failed to stimulate C / EBP alpha and p 21 protein expression and promoter activities . ^^^ Our results have established a functional link between the glucocorticoid receptor signaling pathway that mediates a G 1 cell cycle arrest of rat hepatoma cells and the transcriptional control of p 21 by a cascade that requires the steroid induction of C / EBP alpha gene expression . . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| Further analysis indicated that GR specifically potentiated the induction of transcription by C / EBP beta , but not C / EBP alpha or delta , and that full induction could be obtained by the ligand binding domain ( LBD ) of GR alone . ^^^ C / EBP beta , but not C / EBP alpha or delta , reciprocally potentiated transcriptional activation by DNA bound GR LBD . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| FINDINGS : Both classes of drugs ( 10 ( 8 ) mol / L ) activated C / EBP alpha and the glucocorticoid receptor with different kinetic profiles , and inhibited proliferation . ^^^ The action of the drugs alone or in combination on transcription factor activity and proliferation was suppressed by either depletion of C / EBP alpha or in the presence of a glucocorticoid receptor blocker . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| The glucocorticoid receptor ( GR ) , in the presence of its hormone ligand , inhibited the activation of the PEPCK C gene promoter by C / EBP alpha or C / EBP beta but not by the adipocyte specific peroxisome proliferator activated receptor gamma 2 . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| We show that amlodipine dependent activation of p 21 ( Waf1 / Cip1 ) involves the action of the glucocorticoid receptor ( GR ) and C / EBP alpha . ^^^ Amlodipine induced p 21 ( Waf1 / Cip1 ) promoter activity and expression were abrogated by C / EBP alpha antisense oligonucleotide or by the GR antagonist RU 486 . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| The activity of the IL 6 and LIF responsive genes depends in part on transcription factors including several members of the C / EBP family , JunB and the glucocorticoid receptor . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| Apart from the glucocorticoid receptor , two liver specific nuclear factors possess multiple binding sites in each of these GRUs : C / EBP and a newly identified liver specific factor : HNF 5 . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| Thus , the induction of angiotensinogen gene transcription involves interaction between the glucocorticoid receptor and either one of the APRE binding proteins : either the cytokine inducible NFkB or the constitutive family of C / EBP like proteins , bound to adjacent enhansons in a mutually synergistic enhancer complex . . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| These factors include the glucocorticoid receptor , nuclear factor kappa B and members of the CAAT / viral enhancer ( C / EBP ) family of DNA binding proteins . . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| Several previously defined casein gene promoter regions capable of conferring hormone and extracellular matrix inducibility to reporter genes in mammary cells are suggested to be composite response elements , containing putative binding sites for the same set of hormonally and developmentally regulated factors : C / EBP , MGF / Stat5 , and the glucocorticoid receptor . . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| In addition , a 1000 bp region of the GR promoter has been sequenced which contains consensus sequences for putative DNA binding proteins involved in tissue specificity ( c / EBP ; HNFI ) or hormonal regulation ( steroid receptor ) . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| The C / EBP sites are located in close proximity to the previously characterized binding sites for the prolactin inducible mammary gland factor / signal transducer and activator of transcription 5 , the nuclear factor YY 1 , and the glucocorticoid receptor . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| In all these clones , the tTA trans activator not only modulates the activity of the luciferase gene , but also modulates the activity of a number of endogenous proteins , including C / EBP beta , the glucocorticoid receptor ( GR ) , and SP 1 . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| The specific regulatory effects of glucocorticoid receptor , C / EBP beta , and Ets proteins were documented by co transfection . . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| This enhancer contains multiple protein binding sites , including sites for ubiquitous factors ( NF 1 and AP 1 ) , the glucocorticoid receptor , and the hepatocyte enriched transcription factors hepatocyte nuclear factor 1 ( HNF 1 ) and C / EBP . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| The synergism was shown to be mediated by a complex hormone response region with multiple binding sites for Stat 5 , the glucocorticoid receptor , and CCAAT / enhancer binding proteins ( C / EBP ) . ^^^ In both cell types intact binding sites for Stat 5 and the GR were a prerequisite for the synergism , whereas C / EBP sites were only required in HC 11 cells . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| In the casein promoters , these include binding sites for Stat 5 , Yin Yang 1 ( YY 1 ) , GR and the CCAAT / enhancer binding protein ( C / EBP ) . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| Footprinting experiments showed that the GRU binds not only the glucocorticoid receptor ( GR ) , but also ubiquitous [ nuclear factor 1 ( NF 1 ) ] and liver enriched [ hepatocyte nuclear factor ( HNF ) 3 , HNF 6 , CAAT / enhancer binding protein ( C / EBP ) ] transcription factors . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoid receptor , C / EBP , HNF 3 , and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase 1 gene . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| The APRE contains overlapping recognition sequences for C / EBP ' s and glucocorticoid receptor ( GR ) . ^^^ Electrophortetic mobility shift assays show that this site can bind both GR and C / EBP . ^^^ However , using liver nuclear extract , which contains GR binding activity , only C / EBP binds to the APRE . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| The glucocorticoid receptor is responsible for a moderate stimulation of the promoter activity by dexamethasone and may interact with C / EBP factors to achieve a full transcription activity in basal conditions and in the presence of interleukin 1beta . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| A 102 bp glucocorticoid response unit within the URF , containing binding sites for HNF 3 , C / EBP , and the glucocorticoid receptor , is the main determinant of the hepatocyte specific and hormone controlled activity . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the human promoter is constitutively repressed in hepatocytes by single strand DNA binding proteins whose effects are relieved by C / EBP factors while the glucocorticoid receptor interacts with C / EBPs in chondrocytes to achieve full basal and interleukin 1beta stimulated transcription activity . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| Elements binding known transcription factors such as Sp 1 , Pit 1 , CCAAT enhancer binding protein ( C / EBP ) , glucocorticoid receptor and hypoxia inducible factor 1 ( HIF 1 ) were also identified . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| In additional experiments , we tested the role of glucocorticoids in sepsis induced activation of C / EBP beta and delta by treating rats with the glucocorticoid receptor antagonist RU 38486 . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| The activation of the GR , CCAAT enhancer binding protein ( C / EBP ) , and NF kappaB was induced within 1 to 6 h by C . pneumoniae . ^^^ Our results demonstrate that C . pneumoniae activates C / EBP beta , NF kappaB , and the GR in infected cells . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| In contrast , C / EBPalphap30 bound the C / EBP sites in the PU . 1 or GR gene with 3 6 fold reduced affinity . ^^^ Thus , the selective inhibition of GR expression by C / EBPalphap30 ER is due in part to its variable affinity for C / EBP sites . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| The GRU ( glucocorticoid response unit ) within the distal enhancer of the gene encoding carbamoyl phosphate synthase , which comprises REs ( response elements ) for the GR ( glucocorticoid receptor ) and the liver enriched transcription factors FoxA ( forkhead box A ) and C / EBP ( CCAAT / enhancer binding protein ) , and a binding site for an unknown protein denoted P 3 , is one of the simplest GRUs described . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| This region of the SULT2A 40 / 41 gene does not contain a consensus glucocorticoid receptor responsive element , but does contain two consensus sites for liver enriched CCAAT / enhancer binding protein ( C / EBP ) transcription factors . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| Similarly cotransfection of GR and C / EBP beta or C / EBP delta increases the promoter activity of reporter construct containing nucleoside A at 217 . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| We have also shown that : ( 1 ) reporter constructs containing the AGT gene promoter with nucleoside A at 217 have increased promoter activity on transient transfection ; and ( 2 ) the CCAAT box enhancer binding protein ( C / EBP ) family of transcription factors and glucocorticoid receptor ( GR ) bind preferentially to this region of the promoter when nucleoside A is present at 217 . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| In addition , LeTx also prevented the accessory protein C / EBP from binding to a GR responsive promoter . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| DNaseI footprint analysis revealed seven protected regions and electrophoretic mobility shift , super shift and competition assays identified individual DNA protein complexes capable of binding Sp 1 , estrogen receptor ( ER ) alpha , glucocorticoid receptor and CCAAT enhancer binding protein ( C / EBP ) gamma transcription factors . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| Several transcription factors have been implicated in the inflammatory process in asthma , including the glucocorticoid receptor ( GR ) , NFkappaB , Activator Protein 1 ( AP 1 ) , Nuclear Factor of Activated T cells ( NF AT ) , cyclic AMP Response Element Binding Protein and more recently , the CCAAT / Enhancer Binding Protein ( C / EBP ) , Peroxisome Proliferator activated Receptor ( PPAR ) and the bZIP transcription factor , Nrf 2 . ^^^ |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49715 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|