| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| Modulation of gene expression by calreticulin binding to the glucocorticoid receptor . ^^^ Here we report that the amino terminus of calreticulin interacts with the DNA binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element . ^^^ Together these results indicate that calreticulin may be important in gene transcription , regulating the glucocorticoid receptor and perhaps other members of the super family of nuclear receptors . . ^^^ |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| Transient transfection assays were carried out to investigate the effects of different intracellular targeting of calreticulin on transactivation mediated by glucocorticoid receptor . ^^^ We conclude that the ER , but not cytosolic , form of calreticulin is responsible for inhibition of glucocorticoid receptor mediated gene expression . ^^^ The N domain of calreticulin binds to the DNA binding domain of the glucocorticoid receptor in vitro ; however , we show that the N+P domain of calreticulin , when synthesized without the ER signal sequence , does not inhibit glucocorticoid receptor function in vivo . ^^^ Furthermore , expression of the N domain of calreticulin and the DNA binding domain of glucocorticoid receptor as fusion proteins with GAL 4 in the yeast two hybrid system revealed that calreticulin does not interact with glucocorticoid receptor under these conditions . ^^^ We conclude that calreticulin and glucocorticoid receptor may not interact in vivo and that the calreticulin dependent modulation of the glucocorticoid receptor function may therefore be due to a calreticulin dependent signaling from the ER . . ^^^ |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| Since glutamine synthetase and calreticulin are known to be involved in glucocorticoid receptor pathways , we tested a number of steroids for their effects on astrocyte proliferation . ^^^ |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| This pathway involves the Ca2+ binding protein calreticulin ( CRT ) , which directly contacts the DNA binding domain ( DBD ) of GR and facilitates its delivery from the nucleus to the cytoplasm . ^^^ |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| Nuclear export of the glucocorticoid receptor is accelerated by cell fusion dependent release of calreticulin . ^^^ Nuclear export of GR and other nuclear receptors has been proposed to depend on direct interactions with calreticulin , which is predominantly localized to the lumen of the endoplasmic reticulum . ^^^ We show that rapid calreticulin mediated nuclear export of GR is a specific response to transient disruption of the endoplasmic reticulum that occurs during polyethylene glycol mediated cell fusion . ^^^ Using live and digitonin permeabilized cells we demonstrate that , in the absence of cell fusion , GR nuclear export occurs slowly over a period of many hours independent of direct interaction with calreticulin . ^^^ |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| The results showed that the apparent binding capacity ( Ro ) and the apparent dissociation constant ( Kd ) of GCR were 8468 + / 993 sites per cell and 10 . 2 + / 0 . 6 nM ( n = 6 ) , respectively , under unstressed condition . ^^^ |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| Scatchard plot of the specific binding of 3H dexamethasone to the macrophages indicated that the Kd and Ro of glucocorticoid receptor was approximately 3 . 0 nM and 5 , 500 binding sites per cell , respectively . ^^^ |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| The maximal binding capacity ( Ro ) and dissociation constant ( Kd ) of glucocorticoid receptor ( GCR ) in peripheral leukocytes were estimated by radioligand binding method and the plasma cortisol levels measured in 25 stroke patients ( hemorrhagic 15 , ischemic 10 ) , compared with 12 healthy controls , the plasma cortisol level in stroke patients were significantly higher . ^^^ Ro of leukocytic GCR in hemorrhagic stroke were significantly lower than that of ischemic stroke and controls . ^^^ Ro of GCR in 15 hemorrhagic stroke , 10 ischemic stroke patients and 12 controls were 3496 + / 424 , 5678 + / 1101 and 5940 + / 763 sites / cell respectively kd of GCR were 10 . 47 + / 4 . 17 , 7 . 01 + / 3 . 24 and 5 . 81 + / 1 . 05 nmol / L respectively . ^^^ |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| The glucocorticoid receptor capacity Ro and the dissociation constant Kd were determined in the liver of Xenopus laevis by Scatchard analysis . ^^^ |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| Minimal inhibitory concentrations ( MIC ) and minimal bactericidal concentrations ( MBC ) were determined for ceftazidime ( GR 20263 pentahydrate ) , RO 13 9904 , cefoperazone , cefotaxime , lamoxactam , cefamandole and ampicillin using clinical isolates of beta lactamase producing and beta lactamase negative Haemophilus influenzae . ^^^ |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| Ro 13 9904 and GR 20263 , two new cephalosporins with broad spectrum activity : an in vitro comparison with other beta lactam antibiotics . ^^^ |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| The binding capacity ( Ro ) of high affinity glucocorticoid receptor ( GRH ) decreased significantly 1 h after injection and maintained at low level , whereas the Ro of GRL increased at 1 , 24 , and 48 h after injection . ^^^ |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| At endoscopy RO was diagnosed in 107 of 1687 patients ( 6 . 4 % ) : 17 ( 15 . 9 % ) grade 1 , 34 ( 31 . 8 % ) gr . 2 , 42 ( 39 . 3 % ) gr . 3 and 14 ( 13 . 1 % ) gr . 4 RO ( Savary Miller classification ) . ^^^ |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| When combined with Ro 48 8391 , the beta lactamase inhibitor Ro 48 8724 was superior to the combination of Ro 48 8391 and Ro 48 5545 in spectrum and enzyme inhibition against extended spectrum beta lactamase enzyme producing Escherichia coli and Klebsiella pneumoniae , and against Enterobacteriaceae with `` stably derepressed ' ' Bush Jacoby Medeiros gr 1 enzymes ( ceftazidime resistant Enterobacter and Citrobacter ) . ^^^ |
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| Interacting proteins: P27797 and P04150 |
Pubmed |
SVM Score :0.0 |
| On interaction experiments , ketanserin ( 5 HT ( 1D / 2A / 2C ) antagonist ) slightly enhanced tianeptine effects , while WAY 100635 ( 5 HT ( 1A ) antagonist ) , SB 224289 ( 5 HT ( 1B ) inverse agonist ) , SB 200646 ( 5 HT ( 2B / 2C ) antagonist ) , ondansetron ( 5 HT ( 3 ) antagonist ) , GR 127487 ( 5 HT ( 4 ) antagonist ) , Ro 04 6790 ( 5 HT ( 6 ) antagonist ) , DR 4004 ( 5 HT ( 7 ) antagonist ) , or fluoxetine ( an inhibitor of 5 HT reuptake ) blocked the facilitatory tianeptine effect . ^^^ |
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