| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.60768461 |
| We have also shown that TBP , Ada 2 , and CBP can interact with both the tau 1 core and the GR ligand binding domain , offering a possible mechanism for synergistic interaction between the tau 1 core and other receptor activation domains . 0.60768461^^^ |
|
| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.50479682 |
| Our results support a model in which TBP binding interaction with the GR AF 1 induces significantly greater helical structure in the AF 1 domain . 0.50479682^^^ |
|
| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.86585328 |
| It is known that the GR can interact in vitro with TBP , but the direct interaction of TBP with GR has not been previously characterized quantitatively and has not been appreciated as an important step in assembling the transcriptional complex . 0.86585328^^^ |
|
| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.0 |
| These results are consistent with a model in which binding of the glucocorticoid receptor to glucocorticoid regulatory elements on the surface of nucleosome B induces a chromatin transition that is necessary for transcription factor ( NF 1 and TFIID ) recruitment to the MMTV promoter . ^^^ |
|
| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.0 |
| Taken together , these results indicate that the tau 1 transactivation domain of the human glucocorticoid receptor interacts directly with the general transcriptional apparatus through some target protein ( s ) that is distinct from the TATA binding factor . ^^^ |
|
| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.0 |
| ASC 2 also interacted with other nuclear receptors , including retinoic acid receptor , thyroid hormone receptor , estrogen receptor alpha , and glucocorticoid receptor , basal factors TFIIA and TBP , and transcription integrators CBP / p300 and SRC 1 . ^^^ |
|
| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.0 |
| Additionally , since SPT 3 has been shown to contact yeast TBP directly and is the likely homolog of human TBP associated factor TAFII 18 , we propose that RSP5 / hRPF1 and SPT 3 establish a functional link between activated PR and GR and the general transcription apparatus . . ^^^ |
|
| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.0 |
| These results suggest a mechanism by which the GR tau 1 domain might contribute to gene activation by recruitment of the TFIID complex to target promoters . . ^^^ |
|
| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.0 |
| The GR and TATA binding protein ( TBP ) bound to the cognate overlapping elements in a mutually exclusive manner . ^^^ The GR preferentially inhibited the binding of TBP . ^^^ The isolated DNA binding domain of the GR is sufficient to compete for TBP binding . ^^^ The integrity of both half sites of the glucocorticoid response element ( GRE ) is required to effectively compete for TBP binding , and competitive binding of the GR is dependent on dimerization . ^^^ |
|
| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.0 |
| Our results support a model wherein competitive DNA binding of GR and TBP for their overlapping sites explains conditional repression of the osteocalcin gene by glucocorticoids . . ^^^ |
|
| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P20226 |
Pubmed |
SVM Score :0.0 |
| NA |
|