| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.87928044 |
| These studies suggest that direct interactions between NF kappa B and glucocorticoid receptor may partly account for the antiinflammatory properties of glucocorticoids in vivo . . 0.87928044^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.63043485 |
| Transcriptional activation of the u PAR gene involves PKC dependent mechanisms , and glucocorticoid suppression is probably due to interactions between the glucocorticoid receptor and another transcriptional activating system such as activator protein 1 ( AP 1 ) and / or nuclear factor kB ( NF kB ) . . 0.63043485^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.65871921 |
| These results suggests that NF kappaB interaction with the glucocorticoid receptor does not displace NF kappaB from its DNA binding site but rather changes the complex into a transcriptionally inert form . . 0.65871921^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.55514453 |
| The interactions between NF kappaB and the glucocorticoid receptor result in differing effects on histone modifications and chromatin remodelling . 0.55514453^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.54982374 |
| The interactions between NF kappaB and the glucocorticoid receptor result in differing effects on histone acetylation and deacetylation . 0.54982374^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :1.054701 |
| There was a significant reduction in the interaction between GR and AP 1 in these steroid resistant patients , although interaction with other transcription factors activated in inflammation ( NF kappa B and CREB ) was unaffected . 1.054701^^^ To study this reduced DNA binding , we examined the ability of the nuclear translocated transcription factors activator protein 1 ( AP 1 ) , nuclear factor kappa B ( NF kappa B ) and cyclic AMP response element binding protein ( CREB ) to bind to their DNA binding sites and to interact with GR in PBMC from patients with steroid sensitive and steroid resistant asthma . 0.80286175^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.67268939 |
| These studies demonstrate that cross signaling between AP 1 and NF kappa B with GR may explain the anti inflammatory properties of glucocorticoids in airway epithelial cells . . 0.67268939^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.85354773 |
| Thus , synergistic and antagonistic interactions between GR , NF kappa B , and STAT 5 involve ( a ) cross talk mechanisms influencing the activation of STAT 5 and ( b ) promoter dependent interactions modulating the DNA binding activity of the transcription factors . . 0.85354773^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.56060103 |
| We have studied the interaction between GR and NF kappa B using in vivo like conditions . 0.56060103^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Taken together , these findings suggest that the activated glucocorticoid receptor inhibits signaling pathways which include expression of the EGR 1 and NF kappa B genes and that such effects may contribute to a block in TPA induced monocytic differentiation . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Thus , the induction of angiotensinogen gene transcription involves interaction between the glucocorticoid receptor and either one of the APRE binding proteins : either the cytokine inducible NFkB or the constitutive family of C / EBP like proteins , bound to adjacent enhansons in a mutually synergistic enhancer complex . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| We have tested the activity of this IE protein with a set of well defined promoters containing a TATA box and one type of upstream factor binding site ( for Sp 1 , NF kappa B , heavy metal responsive factors , octamer factors or glucocorticoid receptor ) . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| In the corresponding promoter regions of the various exons , possible response elements for the glucocorticoid receptor , as well as potential binding sites for the AP 1 , AP 2 , and NF kappa B transcription factors are found . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| The newly identified NF kappa B enhancer ( TGGAAATTCC ) is bound by a TNF alpha induced nuclear protein and appears to be the key element in rapid transcription induction by TNF alpha ( and TPA ) , while transactivation of this element is repressed by the ligand bound glucocorticoid receptor . ^^^ We propose a negative cross talk between the NF kappa B transcription factor and the glucocorticoid receptor . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| These data suggest that the activated glucocorticoid receptor prevents ( by a protein / protein interaction ) the binding of transcription factor NF kappa B , but not AP 1 , to the NOS 2 promoter , thereby inhibiting the induction of NOS 2 transcription . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Most of them do not carry a classical binding site for regulation by a glucocorticoid receptor , but have instead regulatory sequences for transcription factors such as AP 1 or NF kappa B . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| The rat MPG promoter does not contain a TATA box , but has a CCAAT sequence element and putative binding sites for the transcription factors Sp 1 , AP 2 , AP 3 , Ets 1 , PEA 3 , NF 1 , p 53 , c Myc , NF kappa B , and the glucocorticoid receptor . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| In this report we present evidence that the ligand activated glucocorticoid receptor ( GR ) is able to repress RelA mediated activation of the ICAM 1 NF kappa B site . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| In transfection experiments , DEX treatment in the presence of cotransfected glucocorticoid receptor ( GR ) inhibits NF kappa B p 65 mediated gene expression and p 65 inhibits GR activation of a glucocorticoid response element . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Anti inflammation : direct physical association and functional antagonism between transcription factor NF KB and the glucocorticoid receptor . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Interestingly , dexamethasone , but not pentamidine , decreased TBT induced NF kappaB activation , confirming in vivo that the glucocorticoid receptor interacts functionally within the nucleus with other transcription factors opposing one another ' s activity . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Inhibition of inflammatory response is primarily mediated via the glucocorticoid receptor and the two transcription factors , AP 1 and NF kappa B , which are of crucial importance for the expression of pro inflammatory cytokines and other genes involved in the inflammatory process . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Distinct domains of the RelA NF kappaB subunit are required for negative cross talk and direct interaction with the glucocorticoid receptor . ^^^ The RelA subunit of NF kappaB and the glucocorticoid receptor mutually repress each others transcriptional activity , thus providing a mechanism for immunosuppression . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| I kappaB alpha independent downregulation of NF kappaB activity by glucocorticoid receptor . 1 kappaB alpha is an inhibitor protein that prevents nuclear transport and activation of the transcription factor NF kappaB . ^^^ Here , we show by the use of a mutant glucocorticoid receptor and steroidal ligands that hormone induced 1 kappaB alpha synthesis and inhibition of NF kappaB activity are separable biochemical processes . ^^^ A dimerization defective glucocorticoid receptor mutant that does not enhance the 1 kappaB alpha level is still able to repress NF kappaB activity . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Redox regulation of transcription factors has recently been demonstrated for AP 1 , NF kappaB , Sp 1 and glucocorticoid receptor in vitro and in vivo . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Because the DNA binding activity of the Gal 4 fusion protein was not affected by DEX , it can be concluded that the reduction of gene activation was caused by interference of the activated glucocorticoid receptor with the transactivation potential of the NF kappaB p 65 subunit . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NF kappa B and the glucocorticoid receptor ( GR ) physically interact , resulting in repression of NF kappa B transactivation . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| In vitro studies have shown protein protein interactions between NF kappaB and the glucocorticoid receptor , possibly explaining their mutual repression of transcriptional activity . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| The p 65 ( RelA ) component of nuclear factor kappaB ( NF kappaB ) and the glucocorticoid receptor ( GR ) mutually repress each other ' s ability to activate transcription . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoids ( GCs ) influence a great variety of cellular functions by at least three important modes of action : the activation ( or repression ) of genes controlled by binding sites for the glucocorticoid receptor ( GR ) , the induction of apoptosis in lymphocytes and the recently discovered cross talk to other transcription factors such as NF kappaB . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Although all three compounds inhibited PMA induced AP 1 transcriptional activity in cell based reporter assay , these compounds exhibited differential effects in separate transcriptional reporter assays for NF kappaB and glucocorticoid receptor . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoids suppress expression of inflammatory genes by binding glucocorticoid receptor with NF kappaB , and increasing expression of inhibitory protein of NF kappaB , IkappaBalpha . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Ligand induced differentiation of glucocorticoid receptor ( GR ) trans repression and transactivation : preferential targetting of NF kappaB and lack of 1 kappaB involvement . 1 . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| After binding to the glucocorticoid receptor ( GR ) , they repress the synthesis of proinflammatory cytokines via inhibition of the transcription factors AP 1 and NF kappa B . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| TrxR reduce sulfhydryl groups like in cysteins either directly or via their cofactor thioredoxin and thus are involved in protein folding and critical protein protein and protein DNA interactions , e . g . modulation of dimerization and / or DNA binding and ligand binding of transcription factors ( glucocorticoid receptor and other steroid receptors , NF kappa B ) . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Interaction of glucocorticoid receptor isoforms with transcription factors AP 1 and NF kappaB : lack of effect of glucocorticoid receptor beta . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| We argue that negative cross talk between the glucocorticoid receptor and NF kappaB may provide a basis for the molecular mechanism underlying the negative action of corticosteroids on serotonin signaling in the brain . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| In contrast , LPS up regulates mRNA for the glucocorticoid receptor which ligand anti inflammatory steroid dexamethasone ( DEX ) strongly suppresses the LPS induced expression of COX 2 , although both 15d PGJ ( 2 ) and DEX suppressed COX 2 promoter activity by interfering with the NF kappaB signaling pathway . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| CBP ( CREB binding protein ) integrates NF kappaB ( nuclear factor kappaB ) and glucocorticoid receptor physical interactions and antagonism . ^^^ Nuclear factor kappaB ( NF kappaB ) and the glucocorticoid receptor ( GR ) are transcription factors with opposing actions in the modulation of immune / inflammatory responses . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoids inhibit cytokine induced transcription factors ( NFkB , AP 1 ) and cytokines enhance glucocorticoid receptor ( GR ) transcriptional activity , thus reciprocally fine tuning immunological control mechanisms . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| This is associated with reduced glucocorticoid receptor ( GR ) expression , increased levels of membrane CD 28 , increased NF kappaB DNA binding activity , and increased binding to the CD 28 response element in the interleukin 2 gene promoter . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| In contrast , glucocorticoid repression of TNF driven IL 6 gene expression does not depend on abrogation of histone acetyltransferase activity , but originates from interference of the liganded glucocorticoid receptor with the contacts between NF kappa B p 65 and the promoter configuration around the TATA box . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Cytoplasmic catalytic subunit of protein kinase A mediates cross repression by NF kappa B and the glucocorticoid receptor . ^^^ Negative transcriptional regulation or cross coupling between NF kappa B ( RelA ) and the glucocorticoid receptor ( GR ) is proposed to play a regulatory role in human physiology and disease . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| It has been shown that the molecular mechanism by which cytokines and glucocorticoids mutually antagonize their functions involves a mutual glucocorticoid receptor ( GR ) / nuclear factor kappa B ( NF kappa B ) transrepression . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| The immunosuppressive effects of glucocorticoids arise largely by inhibition of cytokine gene expression , which has been ascribed to interference between the glucocorticoid receptor and transcription factors such as AP 1 and NF kappa B as well as by competition for common coactivators . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Because dexamethasone interferes with NF kappaB activation , we determined whether dexamethasone inhibits prostate cancer growth by working through the glucocorticoid receptor ( GR ) to interfere with NF kappaB IL 6 pathway . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| However , in Caco 2 cells glucocorticoid receptor overexpression resulted in a marked decrease in NF kappaB activity even in absence of dexamethasone . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Overexpression of the human glucocorticoid receptor alpha and beta isoforms inhibits AP 1 and NF kappaB activities hormone independently . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Herpes simplex virus type 1 infection and glucocorticoid treatment regulate viral yield , glucocorticoid receptor and NF kappaB levels . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor alpha ( TNF alpha ) and its downstream transcription factor nuclear factor kappa B ( NF kappa B ) suppress glucocorticoid action , contributing to tissue resistance to glucocorticoids in several pathologic inflammatory states . p 160 nuclear receptor coactivators on the other hand , contribute to the transcriptional signal of the glucocorticoid receptor ( GR ) through interaction with it via LXXLL motifs in their nuclear receptor binding ( NRB ) domain . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Inhibition of NF kappa B binding correlates with increased nuclear glucocorticoid receptor levels in acute alcohol treated human monocytes . ^^^ DNA binding of NF kappaB has been suggested to be regulated by other nuclear regulatory factors , including the glucocorticoid receptor ( GR ) . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Corticosteroids reverse histone acetylation at the site of inflammatory gene transcription , either by direct binding of the activated glucocorticoid receptor to NF kappa B associated co activators or by recruitment of histone deacetylases to the activated transcription complex . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| The promoter context determines mutual repression or synergism between NF kappaB and the glucocorticoid receptor . ^^^ The presence of only one GRE in the vicinity of the KB sites abolished this repression and allowed synergistic transcriptional activation by NF kappaB and the glucocorticoid receptor ( GR ) . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NF kappaB signalling is inhibited by glucocorticoid receptor and STAT 6 via distinct mechanisms . ^^^ Proteins from other pathways are also known to regulate NF kappaB negatively , notably the glucocorticoid receptor ( GR ) and IL 4 responsive STAT 6 . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoids exert their pharmacological effects by binding to a glucocorticoid receptor ( GR ) , which promotes expression of its target genes or suppresses transcription mediated by other transcriptional factors , such as nuclear factor kappaB ( NF kappaB ) . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Chlamydia pneumoniae activates epithelial cell proliferation via NF kappaB and the glucocorticoid receptor . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoid ligands specify different interactions with NF kappaB by allosteric effects on the glucocorticoid receptor DNA binding domain . ^^^ Glucocorticoids inhibit inflammation by acting through the glucocorticoid receptor ( GR ) and powerfully repressing NF kappaB function . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| RESULTS : In two validation studies , TELiS accurately detected in vivo activation of NF kappaB and the Type 1 interferon system by HIV 1 infection and pharmacologic activation of the glucocorticoid receptor in peripheral blood mononuclear cells . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| A novel class of phenylpyrazole fused Wieland Miescher ketone derivatives are high affinity , receptor specific , selective modulators of glucocorticoid receptor ( GR ) mediated transcription in vitro , dissociating transactivation , AP 1 repression , and NF kappaB repression from each other . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that : ( 1 ) LPSs , IL 1beta , or overexpression of p65RelA inhibit glucocorticoid receptor ( GR ) mediated CAR transactivation ; ( 2 ) these suppressive effects can be blocked both by pyrrolidine dithiocarbamate , an inhibitor of NF kappaB activation , or by overexpression of SRIkBalpha , a NF kappaB repressor ; and ( 3 ) the GR agonist dexamethasone induces histone H 4 acetylation at the proximal CAR promoter region , whereas LPSs and IL 1beta inhibit this acetylation as assessed via chromatin immunoprecipitation assay . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| HIV 1 Vpr enhances production of receptor of activated NF kappaB ligand ( RANKL ) via potentiation of glucocorticoid receptor activity . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoid receptor ( GR ) mediated transrepression of the transcription factors AP 1 and NF kappaB , responsible for most of the anti inflammatory effects of glucocorticoids , is initiated by the tethering of GR to the promoters of target genes . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Coimmunoprecipitation revealed that 15d PGJ ( 2 ) induced a protein protein interaction between PPARgamma and the glucocorticoid receptor ( GR ) in TNFalpha treated HASM cells , which was enhanced by fluticasone and salmeterol . 15d PGJ ( 2 ) , fluticasone , and salmeterol all inhibited TNFalpha induced histone H 4 acetylation at the eotaxin promoter and NF kappaB p 65 binding to the eotaxin promoter and induced PPARgamma and GR association with the eotaxin promoter , as analyzed by chromatin immunoprecipitation assay . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Clinical usefulness of glucocorticoid receptor beta expression and NF kappaB activity in patients with ulcerative colitis ] . ^^^ Recently , it has been reported that glucocorticoid response is related to the expression of human glucocorticoid receptor beta ( hGRbeta ) and nuclear factor kappa B ( NF kappaB ) activity . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| In ectoderm targeted transgenic mice overexpressing the glucocorticoid receptor ( GR ) [ keratin 5 ( K 5 ) GR mice ] , the NF kappaB activity is greatly decreased due to functional antagonism between GR and NF kappaB . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoid exerts its anti inflammatory effect mainly through the suppression of both AP 1 and NF kappaB by its receptor , glucocorticoid receptor ( GR ) . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Hypertonic sodium chloride induction of cyclooxygenase 2 occurs independently of NF kappaB and is inhibited by the glucocorticoid receptor in A 549 cells . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Differential effects of selected natural compounds with anti inflammatory activity on the glucocorticoid receptor and NF kappaB in HeLa cells . ^^^ Herein , we investigated the effects of structurally diverse alkaloids with anti inflammatory activity ( berberine , sanguinarine , chelerythrine , and colchicine ) on two important anti inflammatory and pro inflammatory players , i . e . glucocorticoid receptor ( GR ) and nuclear factor kappa B ( NF kappaB ) , respectively . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| The balance between expression of intranuclear NF kappaB and glucocorticoid receptor in polymorphonuclear leukocytes in SIRS patients . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Histone deacetylase 2 mediated deacetylation of the glucocorticoid receptor enables NF kappaB suppression . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| To test the hypothesis that the interaction between nuclear factor kappaB ( NF kappaB ) and glucocorticoid receptor alpha ( GRalpha ) is a key pathogenetic mechanism regulating the progression of systemic and pulmonary inflammation in sepsis and acute respiratory distress syndrome ( ARDS ) , we used an ex vivo model of systemic inflammation . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| The glucocorticoid receptor ( GR ) , activator protein 1 ( AP 1 ) , nuclear factor kappa B ( NF kappaB ) and c jun N terminal kinase ( JNK ) regulate the above mentioned processes ; we therefore assessed their role in BD . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| The interaction of the transcription factors , activator protein 1 ( AP 1 ) , nuclear factor kappa B ( NF kappa B ) , and cAMP responsive element binding protein ( CREB ) with DNA and glucocorticoid receptors ( GR ) was analyzed in human peripheral blood mononuclear cells by gel mobility shift assays . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| In summary , these results demonstrate that the inhibition of NF kappaB by glucocorticoids involves two critical amino acids in the C terminal zinc finger of the GR . ^^^ Furthermore , the results from the use of mineralocorticoid receptor and anti glucocorticoids suggest that the mechanisms for GR mediated repression of NF kappaB and AP 1 are different . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that RIP 140 antagonized all GR mediated responses tested , which included activation through classical GRE , the synergistic effects of glucocorticoids on AP 1 and Pbx1 / HOXB1 responsive elements , as well as gene repression through a negative GRE and cross talk with NF kappaB ( RelA ) . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Transrepression results from the inhibitory interaction between the GR and other transcription factors like AP 1 and NF kappa B . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Increases in glucocorticoid binding after somatostatin treatment were associated with similar increases in the ability of GR to transactivate a minimal promoter containing two glucocorticoid response elements ( GRE ) and to interfere with the activation of nuclear factor kappaB ( NF kappaB ) . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Our results indicated that FK 506 induced potentiation of GR mediated repression of synovial COX 2 gene transcription is the result of increased translocation of GR to the nucleus and subsequent repression of NF kappaB transactivation . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| These findings demonstrate that MP may suppress post traumatic inflammatory reaction by inhibiting both the AP 1 and NF kappaB transcription cascades via a GR mechanism . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| GR acts as a direct inhibitor of NF kappa B induced HAT activity and also by recruiting HDAC 2 to the NF kappa B / HAT complex . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| In vitro , effects of physiologic concentrations of etanercept on cytokine protein and mRNA , and NFKB and GR transcription factor activity , were determined using MOT and U 937 cell lines and peripheral blood mononuclear cells . ^^^ MOT TNF alpha expression tripled , mRNA for IL 12 p 40 doubled , GR activity declined in U 937 cells , NFKB was unaffected . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Thus , the ability of the transcription factors AP 1 and NF kappaB to induce gene transcription is attenuated by GR . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| This anti inflammatory role of GR was due at least in part to interference with NF kB , leading to a strong reduction in the kB binding activity without altering the transcriptional levels of the inhibitor IkBa . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| To explore the role of transcription factors in the pathogenesis of MCNS and the therapeutic effects of glucocorticoids , we examined the DNA binding abilities of NF kappaB , AP 1 , and GR in peripheral blood mononuclear cells ( PBMC ) from 6 children with MCNS and 6 healthy controls by electrophoretic mobility shift assay ( EMSA ) . ^^^ There were strong correlations between urinary protein and the baseline DNA binding ability of NF kappaB or AP 1 , or GR . ^^^ These results suggested that the abnormal activation of NF kappaB and AP 1 and the reduction of GR DNA binding abilities may be involved in the pathogenesis of MCNS . ^^^ Inhibition of NF kappaB and AP 1 and enhancement of GR DNA binding abilities by DEX may form the molecular basis of the effects of glucocorticoids in MCNS . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| A transgenic reporter gene controlled by NF kappa B exclusively is also repressed , suggesting that protein protein interaction with other transcription factors such as NF kappa B forms the basis of the anti inflammatory activity of GR . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| GR also antagonized the activity of transcription factors , including NF kappa B , NF AT , and AP 1 , through direct and indirect mechanisms . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| However , group A acted through the NF kappaB pathway to inhibit COX 2 as the response was blocked by the inhibitor geldanamycin which prevents dissociation of GR and the effect was blocked by APDC , the NF kappaB inhibitor . ^^^ In terms of PGE ( 2 ) generation , there is clear evidence of two entirely separate mechanisms of glucocorticoid action , one of which correlates with NF kappaB mediated genomic actions whilst the other , depends upon rapid effects on a cell signalling system which does not require dissociation of GR . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoids , acting via glucocorticoid receptors ( GR ) , are potent anti inflammatory agents , acting to oppose nuclear factor kappa B ( NF kappa B ) function . ^^^ VP22GR , resulting from the addition of VP 22 to the N terminal of GR , was equipotent with the wild type GR in opposing NF kappa B p 65 driven expression of an NF kappa B reporter gene . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Activated GR also antagonized NF kappaB activity through protein protein interaction involving direct complexing with , and inhibition of , NF kappaB binding to DNA ( Simple Model ) , or association with NF kappaB bound to the kappaB DNA site ( Composite Model ) . ^^^ In addition , and according to the Transmodulation Model , GRE bound GR may interact with and inhibit the activity of kappaB bound NF kappaB via a mechanism involving cross talk between the two transcription factors . ^^^ Lastly , GR may compete with NF kappaB for nuclear coactivators , including CREB binding protein and p 300 , thereby reducing and inhibiting transcriptional activation by NF kappaB . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Taken together , these findings suggest that rifampicin inhibits anti CD 95 induced apoptosis in Jurkat T cells by modulating the expression of various molecules regulating apoptosis and its effect appears to be mediated via GR and at least in part through NF kappaB signaling pathway . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| These involve interference with activation / transcription factors such as AP 1 and NF kappaB , as well as binding of the GC GR complex to specific DNA sequences , called glucocorticoid response element `` GRE , ' ' with ensuing CAM gene inhibition . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Expression of NF kappaB and , interestingly , also JNK 1 and p 38 inhibited the activity of the GR . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Although the functional NF kappaB sites were retained in the truncated and mutant c IAP 2 promoter constructs , dexamethasone did not inhibit the TNF alpha induction of luciferase activity , indicating that GR repression through the NF kappaB sites did not occur . ^^^ Regulation of the c IAP 2 gene is therefore unique , as GR and NF kappaB signaling pathways are usually mutually antagonistic , not cooperative . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Treatment of cells with BCNU to inhibit glutathione reductase ( GR ) enhanced the CpG induced intracellular oxidation and decreased the GSH / GSSG , with increased activation of NF kappaB and a doubling in the CpG induced production of IL 6 and TNF alpha . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Coexpression of the coactivator SRC 1a or P 65 subunit of NF kappa B with GR led to enhancement or repression , respectively . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Chromatin immunoprecipitation showed that co treatment with IL 1beta and the glucocorticoid budesonide increased the SCF promoter occupancy by NF kappaB and GR , as compared with IL 1beta and budesonide alone . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| MIAs activate c Jun N terminal kinase ( JNK ) , which phosphorylates and inactivates GR , whereas proinflammatory cytokines , such as IL 6 or IL1beta , induce AP 1 or NF kB activation , respectively , leading to GR inhibition . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| In the present study , we examined the effects of dexamethasone ( Dex ) and Hsp 90 inhibitors , alone and in combination , on the activation of GR and proinflammatory transcription factors such as nuclear factor kappaB ( NF kappaB ) and activator protein 1 ( AP 1 ) . ^^^ These results suggest that Hsp 90 inhibitor itself inhibits the activation of NF kappaB and AP 1 , however , impedes Dex induced inhibition of IL 1beta induction by attenuating Dex mediated activation of GR and inhibition of the proinflammatory transcription factors . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| A common mechanism for LXR and GR mediated repressive actions on gene transcription is inhibition of nuclear factor ( NF ) kappaB ; however , EMSAs and pharmacological interference with NF kappaB signaling provided no evidence for the involvement of NF kappaB in the repressive action of Dex and T 1317 on GH induced akr1b7 expression . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| It is assumed that transrepression of transcription factors such as AP 1 and NF kappa B is the main mechanism by which glucocorticoids mediate their anti inflammatory activity , whereas the side effects of GCs are mainly mediated by GR DNA interaction either by activation or by negative regulation of gene expression . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| The same GRIP 1 corepression domain was required for GR mediated repression at the nuclear factor kappaB ( NF kappaB ) tethering GRE of the human IL 8 gene . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| In particular , most immunosuppressive and anti inflammatory effects are exerted by an interaction of GR with the activating protein 1 ( AP 1 ) and nuclear factor kappaB ( NF kappaB ) families of transcription factors without DNA binding . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Thus , impaired nuclear translocation of GR and the lack of transcriptional suppression of NF kappa B by GC were identified as the molecular mechanisms responsible for the observed GC resistance in spleens of socially stressed mice . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| In osteosarcoma cells , RU 486 revealed a higher potency than cyproterone acetate to prevent responses to dexamethasone induced GR transactivation and NF kappa B transrepression . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Our data clearly indicate that interference of GR transgenic protein with nuclear factor kappa B ( NF kappaB ) transcription factor had resulted in NF kappaB blockage in K 5 GR / ras+ tumors . ^^^ We discuss the role of NF kappaB blockage in tumor suppressor effect of GR . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Results show that , in exercised OVA sensitized mice , treatment with the GR antagonist RU 486 blocked the exercise induced reductions in cellular infiltration of the airways ( p < . 05 ) , KC and soluble VCAM 1 protein levels in the bronchoalveloar lavage fluid ( p < . 05 ) , and NF kappaB translocation and DNA binding within the lung to levels similar to those observed in sedentary OVA sensitized mice . ^^^ Together , these results suggest that GR nuclear translocation and NF kappaB activation play roles in mediating the anti inflammatory effects of exercise in allergen mediated lung pathology . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| DNA binding of GR and NF kappaB are also demonstrated for these effects . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Although the gene activating properties of GR are mainly associated with undesirable side effects , its negative interference with the activity of transcription factors , such as NF kappaB , greatly contributes to its antiinflammatory and immune suppressive capacities . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| The present study shows that PELP 1 does indeed coactivate ER mediated transcription but also serves as a corepressor of other nuclear hormone receptors ( NR ) and non NR sequence specific transcription factors tested , including GR , Nur 77 , AP 1 , NF kappaB , and TCF / SRF . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| GR inhibition of many proinflammatory response genes occurs through induction of the synthesis of anti inflammatory proteins as well as through repression of proinflammatory transcription factors , such as nuclear factor kappaB ( NF kappaB ) or activator protein 1 ( AP 1 ) . ^^^ In this review , we discuss the molecular mechanisms underlying GR inhibition of inflammatory responses , with an emphasis on repression of NF kappaB and AP 1 and their respective signaling pathways . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| In this study , we examine endogenous target genes regulated by a GR mutant that in contrast to the wild type GR is unable to repress stimulated nuclear factor kappaB ( NF kappaB ) activity , whereas repression of activator protein 1 ( AP 1 ) activity is maintained . ^^^ Gene expression profiling of human embryonic kidney 293 cells , which express the wild type GR and the GRR488Q mutant allowed identification of endogenous genes preferentially repressed by GR interference with NF kappaB activity . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Further studies showed decreased p 27 expression , increased PKC alpha expression and enhanced basal and LPS induced NF kappaB activity in RAW ( GR ) cells as compared to the RAW control cells . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| It is postulated that an excess of cytokine induced transcription factors , such as NF kB , may form complexes with activated glucocorticoid receptors ( GCR ) , preventing GCR interaction with DNA . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Moreover , CCI induced a significant downregulation of nuclear factor kappaB ( NF kappaB ) within the ipsilateral spinal cord dorsal horn , which also was attenuated by either RU 38486 ( 4 > 2 = 0 . 5 microg = vehicle ) or a GR antisense oligonucleotide . ^^^ The immunohistochemical data indicated a pattern of colocalization between GR and EAAC 1 as well as GR and NF kappaB within the spinal cord dorsal horn . ^^^ Since , NF kappaB has been shown to regulate the expression of those cellular elements linked to inflammation and tissue injury and its activity can be negatively regulated by GR activation , these results suggest that spinal GR through NF kappaB may play a significant role in the regulation of EAAC 1 expression after peripheral nerve injury , a cellular pathway that may contribute to the development of neuropathic pain behaviors in rats . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| One of the examples of two signal pathways regulating opposite gene expression are NF kB and GR mediated signal pathways . ^^^ NF kB is transcription factor which induces the expression of many genes that participate in immune and inflamatory response , while GR is transcription factor that serves as antiinflammatory agent and immune suppressor . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Here , we report that Vpr uses the GR pathway as a recruitment vehicle for the NF kappaB co activating protein , poly ( ADP ribose ) polymerase 1 ( PARP 1 ) . ^^^ The recruitment of PARP 1 by the Vpr GR complex prevents its nuclear localization , which is necessary for Vpr to suppress NF kappaB . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Our data suggest that the specific action of DEX on GR may enhance the cytotoxicity of cisplatin in selected GR rich cancer cells by suppressing NF kappaB activation . . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| These results indicate that several factors define the responsiveness of the inner ear to GC , including the availability of ligand or receptor , and the nuclear translocation of GR and NF kappaB . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| GR signaling was further characterized by analyzing nuclear factor kappaB ( NF kappaB ) nuclear translocation and protein expression . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| These compounds are efficacy selective in an NFkB GR agonist assay ( representing transrepression effects ) over an MMTV GR agonist assay ( representing transactivation effects ) . 52 and 60 have NFkB pIC ( 50 ) = 8 . 92 ( 105 % ) and 8 . 69 ( 92 % ) and MMTV pEC ( 50 ) = 8 . 20 ( 47 % ) and 7 . 75 ( 39 % ) , respectively . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoids activate glucocorticoid receptors ( GR ) , which act as transcription factors and inhibit transcription induced by NF kappaB and AP 1 . ^^^ |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|