| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.87892096 |
| There was a significant reduction in the interaction between GR and AP 1 in these steroid resistant patients , although interaction with other transcription factors activated in inflammation ( NF kappa B and CREB ) was unaffected . 0.87892096^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.66211239 |
| Since chronic desipramine , and not fluoxetine , is able to increase hippocampal glucocorticoid receptor ( GR ) expression , interactions of GR with CREB and SP 1 may determine the lack of effect of desipramine on binding activity of the two latter transcription factors in this brain region . 6 . 0.66211239^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| However , in F 9 embryonal carcinoma cells which lack endogenous functional cAMP response element binding protein , we have found that PKA is still able to control gene transcription through the glucocorticoid receptor ( GR ) by up regulating its hormone dependent trans activation . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| These results suggest that binding of GR to the negative glucocorticoid response element ( nGRE ) could lead to steric occlusion of positive transcription factors , such as cAMP response element binding protein and tissue specific factors or that GR bound to nGRE could interact with DNA bound positive factors in such a way as to prevent their transcriptional stimulatory activity . . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| This effect appears to be due to an interaction between the glucocorticoid receptor and the transcription factor , cAMP response element binding protein ( CREB ) , which is activated by high concentrations of beta 2 adrenoceptor agonists . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| The region upstream of the transcription start site is characterized by the presence of a TATA box at bases 32 / 26 , DNA binding elements for transcription factors c Myc , N Myc , Sp 1 and nuclear factor kappaB as well as putative activator protein ( AP ) 1 , cAMP response element binding protein ( CREB ) , hepatocyte nuclear factor ( HNF ) 1 , HNF 3 , TGT 3 , gut enriched Krppel factor ( GKLF ) , thyroid transcription factor ( TTF ) 1 and glucocorticoid receptor element ( GRE ) binding sites . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Hormone responsiveness is conferred by the tissue specific HSIII enhancer and involves ( 1 ) protein kinase A mediating the cAMP response , even though a consensus sequence for binding of the cAMP response element binding protein is not present ; ( 2 ) other serine / threonine kinases as deduced from inhibitor studies ; ( 3 ) glucocorticoid receptor protein bound to glucocorticoid response element half sites ; and ( 4 ) binding of the liver enriched transcription factor hepatocyte nuclear factor 1 ( HNF 1 ) to sites in the enhancer . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| A number of transcription factors , including CCAAT / enhancer binding protein beta ( C / EBPbeta ) , glucocorticoid receptor , cAMP response element binding protein ( CREB ) , and Nopp 140 , are known to participate in its induction . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Putative binding motifs for the transcription factors sex determining region Y gene product , transcriptional repressor CDP , hepatic nuclear factor 3beta , GATA binding factor 1 , glucocorticoid receptor , SRY related high mobility group box protein 5 and cAMP response element binding protein were identified in the 5 ' flanking region of the Pth gene . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| The functional synergy of the p 160 coactivators [ steroid receptor coactivator 1 , glucocorticoid receptor interacting protein ( GRIP 1 ) , or the activator for thyroid hormone and retinoid receptors ] , the histone acetyltransferases cAMP response element binding protein binding protein ( CBP ) and p 300 and the histone methyltransferase coactivator associated arginine methyltransferase ( CARM 1 ) depends on the methyltransferase activity of CARM 1 . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Glucocorticosteroid stimulated gene transcription is mediated by the glucocorticosteroid receptor ( GR ) that recruits coactivators of the p 160 family , forming a docking platform for secondary coactivators , such as cAMP response element binding protein ( CREB ) binding protein ( CBP ) or its close homologue , p 300 . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Here we show that the expression of spinal NMDAR and PKCgamma after chronic morphine is regulated by spinal GR through a cAMP response element binding protein ( CREB ) dependent pathway . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Mutual cross interference between glucocorticoid receptor and CREB inhibits transactivation in placental cells . ^^^ Inhibition by GR is only effective when the alpha subunit promoter is activated by CREB , implicating CREB as the target for GR mediated repression . ^^^ Reciprocally , overexpression of CREB interferes with GR mediated transcriptional activation of MMTV . ^^^ Despite the mutual cross interference with activation of gene expression , GR and CREB do not appear to have a high affinity protein : protein interaction in vitro . ^^^ Nonetheless , GR and CREB may interact directly in vivo possibly through a third protein or , more likely , may sequester a mutually required target protein . . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| GR markedly repressed transactivation by Gal 4 CREB and , to a lesser degree , the Gal 4 thyroid hormone receptor and Gal 4 VP 16 chimeric proteins . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| A similar effect may also be seen with high concentrations of beta 2 agonists that activate another GR binding transcription factor , CREB . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Several other transcription factors including NF IL 6 , AP 1 , AP 2 , GR , CREB , Oct 1 , and Sp 1 are not affected by IL 10 . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| The interaction of the transcription factors , activator protein 1 ( AP 1 ) , nuclear factor kappa B ( NF kappa B ) , and cAMP responsive element binding protein ( CREB ) with DNA and glucocorticoid receptors ( GR ) was analyzed in human peripheral blood mononuclear cells by gel mobility shift assays . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| We show that a full response to glucocorticoids requires two DNA segments : 1 ) a glucocorticoid response unit ( GRU ) , centered at about position 400 , which contains two accessory factor elements ( AF 1 and AF 2 ) and two glucocorticoid receptor binding sites ( GR 1 and GR 2 ) , and 2 ) a basal promoter / cyclic AMP response element ( E / CRE ) at about position 90 , which binds the transcription factor CREB . ^^^ A protein protein interaction was observed in vitro between GR and CREB that might account for the role of the E / CRE in the glucocorticoid response of the PEPCK gene . . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| There may be an abnormal activation of AP 1 in steroid resistant asthma , and high concentrations of beta 2 agonists may induce a secondary resistance by an interaction between the transcription factor CREB and the glucocorticoid receptor . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| GR also exerts negative actions on transcription , e . g . , by interfering with the function of several other transcription factors such as AP 1 , NK kappa B , CREB , and Oct 1 . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| In lung cells , high doses of beta 2 agonists reduce the ability of GR to bind DNA , a process which is mediated by CREB activation . ^^^ Inhibition of GR DNA binding by CREB raises the possibility that high dose beta 2 agonists could have functional antiglucocorticoid activity and may be a basis for the reported increase in asthma morbidity and mortality in industrialized countries , which have increasing per capita beta 2 agonist use . . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| The cAMP responsive element binding protein ( CREB ) and the glucocorticoid receptor ( GR ) have been reported to bind to a 60 bp promoter fragment of the alpha 1 GABAA receptor gene containing a classic cAMP responsive element ( CRE ) . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Relative mobility shift and binding studies suggest that CRE binding protein ( CREB ) , CREB modulator ( CREM ) , or CREB / CREM may be associated with the c jun AP 1 and / or GR AP 1 sites , but the association at these sites occurs at a lower binding affinity than for a consensus CRE . ^^^ These data raise the possibility that the promiscuous binding of CREB and / or CREM to the AP 1 site , and AP 1 transcription factors to one or more CREs , in the GR promoter may contribute to the regulation of GR gene expression . . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Our data suggest that several trans acting factors including CREB , AP 2 , and GR are likely to be involved in vasopressin gene transcription and that the positive and negative regulation of vasopressin gene transcription is complex . . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Shift mobility showed binding of CREB in vitro to a putative cAMP responsive element located at 1000 , suggesting that hGR may be upregulated by cAMP at the transcriptional level , thus adding a new mechanism ascribable to this second messenger , which in conjunction with the cAMP induced GR mRNA increased stability , would lead to a more precise control of the amount of GR protein within the cell . . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Recent studies have suggested that regular use of beta 2 agonists has adverse effects on asthma control , due to the cross talk between cAMP responsive element binding proteins ( CREB ) and glucocorticoid receptors ( GR ) . ^^^ The aim of this study was to investigate the interaction between GR and CREB on cytoplasmic protein level with a gel mobility shift assay and to determine the effect of this interaction on mRNA levels by Northern blot analysis . ^^^ After exposing human bronchial epithelial cells for 1 hr to either 1 microM terbutaline or budesonide , more binding of CREB and GR , respectively , was observed to their responsive elements in DNA . ^^^ Simultaneous exposure to terbutaline and budesonide also increased the binding of CREB and GR to DNA . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| These results suggest that the GS cGRE can potentially integrate signaling from both the cAMP and glucocorticoid receptor transduction pathways and that CREB / ATF 1 may play an important role in this process . . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| A mutual inhibition between GR and CREB occurs in vitro which raises the possibility of a negative interaction between corticosteroid and beta agonist drugs . ^^^ Biopsy samples of the bronchial mucosa were obtained after each treatment and analysed for the DNA binding activity of GR , CREB , and NFkappaB . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| CBP ( CREB binding protein ) integrates NF kappaB ( nuclear factor kappaB ) and glucocorticoid receptor physical interactions and antagonism . ^^^ To further characterize p 65 GR interactions , we examined the role of the transcriptional co integrator CREB binding protein ( CBP ) in their mutual antagonism . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we show that GR acts both as a direct inhibitor of CREB binding protein ( CBP ) associated HAT activity and also by recruiting HDAC 2 to the p 65 CBP HAT complex . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Analysis of the 2 . 5 kb 5 ' flanking sequence shows putative binding sites for several transcription factors , including GATA 1 , IRF 2 , Pit 1 , myogenin , CREB , Sp 1 , Ap 2 , MAZ , and GR . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Both factors make use of the coactivator cAMP response element binding protein ( CREB ) binding protein ( CBP ) to enhance their transcriptional activities , which led to the hypothesis that a mutual antagonism between p 65 or c Jun and activated glucocorticoid receptor ( GR ) results from a limited amount of CBP . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| In addition , this reactivation of the adult cells was also preceded by an increased expression of glucocorticoid receptor ( GR ) and cyclic AMP response element binding protein ( CREB ) , two transcription factors that together with TR appear to play important roles in the control of neonatal oligodendrocyte development . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Altered regulation of CREB by chronic antidepressant administration in the brain of transgenic mice with impaired glucocorticoid receptor function . ^^^ A transgenic animal model of depression with impaired glucocorticoid receptor function was used to investigate the effect of chronic antidepressant treatments on CREB expression in different brain areas . ^^^ Our findings suggest that life long central glucocorticoid receptor dysfunction results in an altered sensitivity with respect to the effects of antidepressants on the expression of CREB . . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Lastly , GR may compete with NF kappaB for nuclear coactivators , including CREB binding protein and p 300 , thereby reducing and inhibiting transcriptional activation by NF kappaB . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| The cyclic AMP response element binding protein ( CREB ) and the glucocorticoid receptor ( GR ) are altered by chronic treatment with antidepressants . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Chronic glucocorticoid receptor activation impairs CREB transcriptional activity in clonal neurons . ^^^ We provide evidence that chronic activation of the glucocorticoid receptor ( GR ) in clonal neurons inhibits the transcriptional activity of the cyclic AMP response element binding protein ( CREB ) , which is believed to be involved in memory processes . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Analysis of the 5 ' flanking region revealed that the promoter is TATA less , and contains consensus binding sites for transcription factors such as Sp 1 , glucocorticoid receptor ( GR ) , activating transcription factor ( ATF ) and cAMP response element binding protein ( CREB ) . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Studies are testing a hypothesis that hippocampal transcriptional mechanisms and gene expression profiles linked to activator protein 1 ( AP 1 ) and glucocorticoid receptor ( GR ) , mineralocorticoid receptor ( MR ) or cyclic AMP response element binding protein ( CREB ) families of transcription factors distinguish successful or unsuccessful aging and cognition . ^^^ Results from mRNA assays , in situ hybridization , electromobility shift assays and western immunoblot indicate changes in GR and CREB in AI rats . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| This result was further confirmed by the fact that GR induced the phosphorylation of CRE binding protein ( CREB ) and inhibition of glycogen synthase kinase 3beta phosphorylation as well as the production of cAMP , indicating that GR induces melanogenesis through cAMP signaling . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| In the present study , we found that chronic treatment of rats with the selective GR antagonist ORG 34116 decreased the immobility time in the forced swim test , increased baseline levels of phosphorylated CREB ( P CREB ) in the DG and neocortex and affected the forced swimming induced changes in P CREB levels in a time and site specific manner . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| Activation of the genes encoding gluconeogenic enzymes is mediated by hormone responsive transcription factors such as the cyclic AMP response element binding protein ( CREB ) and the glucocorticoid receptor ( GR ) . ^^^ Foxa 2 mediates these effects by enabling recruitment of CREB and GR to their respective target sites in chromatin . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| The GSE treatment also led to the down regulation of two transcription factors , cyclic AMP responsive element binding protein 1 ( CREB 1 ) and glucocorticoid receptor ( GR ) . ^^^ CREB 1 and GR are known to up regulate aromatase gene expression through promoters I . 3 / II and I . 4 , respectively . ^^^ |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|