| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.56285815 |
| In the present study , we hypothesized that the DNA binding domain ( DBD ) of the GR , which is highly conserved among the nuclear receptors , is also responsible for communication with TRX in vivo . 0.56285815^^^ |
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| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| In mammalian cells , thioredoxin functions as an endogenous glucocorticoid receptor activating factor and as an adult T cell leukemia derived factor ( ADF ) that stimulates expression of interleukin 2 receptor in human T cell leukemia virus ( HTLV ) 1 transformed T cells . ^^^ |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| The drug is a potent alkylating agent and rapidly chloroethylates the active sites of the important thioproteins thioredoxin reductase ( TR ) , glutathione reductase ( GR ) and ribonucleotide reductase ( RR ) . ^^^ |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| Levels of thioredoxin reductase ( TR ) , glutathione reductase ( GR ) , superoxide dismutase ( SOD ) , and catalase ( CAT ) were determined in S91 / amel and S91 / I3 . ^^^ |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| Stress , catecholamines ( CA ) , cAMP and protein kinase A do not affect superoxide dismutase , catalase , thioredoxin reductase , thiol transferase and glutathione reductase ( GR ) . ^^^ |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| The heat stable cytosolic factor that promotes glucocorticoid receptor binding to DNA is neither thioredoxin nor ribonuclease . ^^^ |
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| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| Proof that the endogenous , heat stable glucocorticoid receptor activating factor is thioredoxin . ^^^ In this paper we show that NADPH dependent conversion of the rat liver glucocorticoid receptor from a nonbinding to a steroid binding form is blocked in an immune specific manner by antisera raised against purified rat liver thioredoxin reductase or thioredoxin . ^^^ These observations prove that the endogenous glucocorticoid receptor activating factor is thioredoxin and that the enzyme required for generating the steroid binding conformation of the glucocorticoid receptor by the endogenous receptor activating system is thioredoxin reductase . . ^^^ |
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| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| This enzyme distinguishes from other reducing enzymes such as thioredoxin that do not require GSH and GR for their catalytic activity . ^^^ |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| TrxR reduce sulfhydryl groups like in cysteins either directly or via their cofactor thioredoxin and thus are involved in protein folding and critical protein protein and protein DNA interactions , e . g . modulation of dimerization and / or DNA binding and ligand binding of transcription factors ( glucocorticoid receptor and other steroid receptors , NF kappa B ) . ^^^ |
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| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| In addition , overexpression of thioredoxin restored glucocorticoid receptor action on the alpha ENaC GRE in the presence of exogenous H ( 2 ) O ( 2 ) . ^^^ |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| Mammalian thioredoxin reductases ( TrxR ) are homodimers , homologous to glutathione reductase ( GR ) , with an essential selenocysteine ( SeCys ) residue in an extension containing the conserved C terminal sequence Gly Cys SeCys Gly . ^^^ |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| Since these cells have a much higher redox capacity than RAW 264 . 7 cells as judged by GR activity and thioredoxin reductase activity it wound minimize cellular damage , including inactivation of GR caused by nitrosative stress . . ^^^ |
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| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| Intracellular defense systems that protect cells from ROS induced damage include glutathione reductase ( GR ) , thioredoxin reductase ( TrxR ) , superoxide dismutase ( Sod ) , and catalase ( Cat ) . ^^^ |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| Our in vitro kinetic inhibition experiments with 4 OHEN showed that GST P 1 1 had a lower K ( 1 ) value ( 20 . 8 microM ) compared to glyceraldehyde 3 phosphate dehydrogenase ( GAPDH , 52 . 4 microM ) , P 450 reductase ( PR , 77 . 4 microM ) , pyruvate kinase ( PK , 159 microM ) , glutathione reductase ( GR , 230 microM ) , superoxide dismutase ( SOD , 448 microM ) , catalase ( 562 microM ) , GST M 1 1 ( 620 microM ) , thioredoxin reductase ( TR , 694 microM ) , and glutathione peroxidase ( GPX , 1410 microM ) . ^^^ |
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| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| The enzyme appeared to evolve by a carboxy terminal extension of GR such that the resulting carboxy terminal glutathionelike peptide became an intramolecular substrate for GR and a reductant for thioredoxin . ^^^ |
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| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| Cellular defense systems against reactive oxygen species ( ROS ) include thioredoxin reductase ( TrxR ) and glutathione reductase ( GR ) . ^^^ The fruit fly Drosophila lacks a functional GR , suggesting that the thioredoxin system is the major source for recycling glutathione . ^^^ |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| Thioredoxin reductase ( TR ) and glutathione reductase ( GR ) are the two critical enzymes in the response to oxidative stress in vivo . ^^^ |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| Escherichia coli thioredoxin reductase ( TR ) and glutathione reductase ( GR ) are dimeric proteins that require a flavin adenine dinucleotide ( FAD ) cofactor for activity . ^^^ |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| A most important antioxidative system consists of ( di ) thiols which are recycled by disulfide reductases ( DR ) , namely both glutathione reductases ( GR ) of the malarial parasite Plasmodium falciparum and man , and the thioredoxin reductase ( TrxR ) of P . falciparum . ^^^ |
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| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| Neutrophil thioredoxin reductase ( TR ) activity increased in basal post diving , and glutathione reductase ( GR ) activity was maintained . ^^^ |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| In an attempt to determine the depolymerization process , various types of Tg multimers , which were generated from deoxycholate treated / reduced Tg , partially unfolded Tg or partially unfolded / reduced Tg , were subjected to various GSH ( reduced glutathione ) reducing systems using protein disulfide isomerase ( PDI ) , glutathione reductase ( GR ) , glutaredoxin or thioredoxin reductase . ^^^ |
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| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| The concept of an evolutionary link between thioredoxin reductase and glutathione reductase ( GR ) is presently discussed and supported by the fact that almost all residues at catalytic and substrate recognition sites are identical . ^^^ |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrated that either antisense TRX expression or cellular treatment with H2O2 negatively modulates GR function and decreases glucocorticoid inducible gene expression . ^^^ Impaired cellular response to glucocorticoids is rescued by overexpression of TRX , most possibly through the functional replenishment of the GR . ^^^ Moreover , not only the ligand binding domain but the DNA binding domain of the GR is also suggested to be a direct target of TRX . ^^^ |
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| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that either antisense TRX expression or cellular treatment with H2O2 negatively modulates GR function and decreases glucocorticoid inducible gene expression . ^^^ Impaired cellular response to glucocorticoids is rescued by overexpression of TRX , most probably through the functional replenishment of the GR . ^^^ Moreover , not only the ligand binding domain but the DNA binding domain of the GR is also suggested to be a direct target of TRX . ^^^ |
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| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| The C terminal extension typical of mammalian TrxRs has two functions : ( 1 ) it extends the electron transport chain from the catalytic disulfide to the enzyme surface , where it can react with Trx , and ( 2 ) it prevents the enzyme from acting as a GR by blocking the redox active disulfide . ^^^ |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10599 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|