Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
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Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
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Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
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Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
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Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
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Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
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Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
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Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.95717081
HeLa cell glucocorticoid receptor bound [ 3H ] triamcinolone acetonide with a dissociation constant ( KD = 1 . 3 nM at 0 degrees C ) that was similar to those of mouse and rat glucocorticoid receptors . 0.95717081^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
This study describes the distribution and frequency of estrogen receptor ( ER ) , progesterone receptor ( PR ) , androgen receptor ( AR ) , and glucocorticoid receptor ( GR ) in a large series of patients with primary metastatic breast cancer . 329 patients were in this series . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Included in addition to effects of estrogen receptor ( ER ) status are the effects of androgen receptor ( AR ) , progesterone receptor ( PR ) , and glucocorticoid receptor ( GR ) on therapy perfornamce . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In support of these findings , danazol bound to the 8 S androgen receptor of rat prostate cytosol and to the glucocorticoid receptor of rat liver cytosol , but danazol did not bind well to the estrogen receptor of the rat uterus . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
DHEA was incapable of inhibiting the binding of [ 3H ] DHT to the androgen receptor or [ 3H ] dexamethasone to the glucocorticoid receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The action of MNNG , as assessed in terms of a ) the affinities for both the glucocorticoid receptor and androgen receptor of mouse , b ) the effects on the turnover of hydrocortisone and dihydrotestosterone in the glandular stomach of mouse , c ) the induction of ornithine decarboxylase in the same tissue , and d ) the interfering effect on the hydrocortisone linked acceleration of water turnover at the whole body level of a mouse , points to the steroid mimetic nature of the carcinogen . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The Mr 90 , 000 heat shock protein free androgen receptor has a high affinity for steroid , in contrast to the glucocorticoid receptor . ^^^ Thus these observations indicate that , in contrast to the glucocorticoid receptor , hsp 90 is not required for the high affinity steroid binding of the androgen receptor . ^^^ In addition , the hsp 90 free androgen receptor prebound with radioinert R 1881 was efficiently relabeled with [ 3H ] R 1881 , while the triamcinolone acetonide bound , transformed glucocorticoid receptor failed in ligand exchange . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The region of RAP 01 which binds androgen receptor complexes has previously been shown to interact with glucocorticoid receptors and contains a 17 bp sequence homologous with the consensus sequence for glucocorticoid receptor binding . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
ZK 98734 bound to the rat thymus glucocorticoid receptor and to the rat ventral prostate androgen receptor with a greater affinity than ZK 98299 . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In order to evaluate age related changes in glucocorticoid receptor and androgen receptor of cultured human pubic skin fibroblasts in young and aged men , we determined both [ 3H ] dexamethasone binding and [ 3H ] methyltrienolone ( R 1881 , potent androgenic steroid ) binding , using dispersed whole cell assay . ^^^ These findings indicate that there were no significant age related changes in binding site and affinity of glucocorticoid receptor in cultured human pubic skin fibroblasts , whereas binding sites of androgen receptor significantly decreased in those of aged men as compared to young men , without significant change in affinity . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Four steroids had an affinity for the glucocorticoid receptor higher than for the androgen receptor . ^^^ The assumption is made that the steroids tested also behave as antagonists when binding to the glucocorticoid receptor in muscle and behave as agonists when binding to the androgen receptor . ^^^ These indices might be of predictive value to determine whether these steroids exert their anabolic action in muscle through the glucocorticoid receptor or through the androgen receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Glucocorticoids specifically inhibit androgen induced androgen receptor augmentation in DDT1MF 2 cells , but not in the GR variant suggesting that growth inhibition is related to inhibition of androgen receptor augmentation . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The presence of typical glucocorticoid and androgen receptors in SC 3 cells was also demonstrated ; dexamethasone did not bind to androgen receptor and testosterone did not bind to glucocorticoid receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The structural requirements for the interaction of about 80 cyclic hydrocarbons and related compounds with the androgen receptor of rat ventral prostate , the estrogen receptor of human breast tumor MCF 7 cells , and the glucocorticoid receptor of rat liver were examined by comparing their abilities to compete with radioactive hormones for binding to the respective receptors . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In the present study , we found that 6MP was bound in kidney cytosol from adrenalectomized / ovariectomized female mice as well as Tfm / Y mice , which lack androgen receptors . 6MP was bound with high affinity ( Kd = 1 . 2 10 10 ( 8 ) M ) by a binder that was present in 7 8 times greater concentration than the androgen receptor and had the specificity of a glucocorticoid receptor . 6MP was bound with similar specificity in liver cytosol . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Temperature also activated glucocorticoid receptor complexes efficiently but activated progesterone and androgen receptor complexes less well . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Since methyltrienolone also binds glucocorticoid receptor which exists in rat liver , the apparent binding of androgen receptor is faulty when measured in the presence of glucocorticoid receptor . ^^^ The binding of methyltrienolone to glucocorticoid receptor can be blocked by the presence of a 100 fold molar excess of unlabeled synthetic glucocorticoid , triamcinolone acetonide , without interfering in its binding to androgen receptor , because triamcinolone does not bind to androgen receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The apparent isoelectric points were 5 . 4 , 5 . 6 and 6 . 2 for the glucocorticoid receptor , and 5 . 9 , 6 . 2 and 8 . 5 for the androgen receptor . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Competition experiments as well as sucrose density gradient analysis indicated that R 1881 , in addition to its binding of the androgen receptor , was also bound to glucocorticoid receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
LG 100127 and LG 100128 each interacted with the human androgen receptor but did not interact with the human glucocorticoid receptor , estrogen receptor , vitamin D receptor , or retinoid receptors . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In the present study the affinity of gestodene to the progesterone receptor ( PR ) , the androgen receptor ( AR ) , the glucocorticoid receptor ( GR ) , the mineralocorticoid receptor ( MR ) and the estrogen receptor ( ER ) was re evaluated by steroid binding assays and compared to those obtained for 3 keto desogestrel and progesterone . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Domains of the human androgen receptor and glucocorticoid receptor involved in binding to the nuclear matrix . ^^^ To obtain insight in the molecular mechanism of the interaction of steroid receptors with the nuclear matrix , we studied the binding of several deletion mutants of the human androgen receptor ( hAR ) and the human glucocorticoid receptor ( hGR ) to the nuclear matrix . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Androgen receptor ( AR ) and glucocorticoid receptor ( GR ) belong to the same subfamily of steroid / nuclear receptors and have been shown to bind qualitatively to the same hormone response element ( HRE ) DNA sequences . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Estrogen receptors ( ER ) were found in KATO 3 cells , transplanted NUGC 3 , and AZ 521 tumors , whereas glucocorticoid receptors ( GR ) were found only in NUGC 3 tumor and no androgen receptor was found in any cell lines or transplanted tumors . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We examined the patterns of conformational changes in the androgen receptor , glucocorticoid receptor , and progesterone receptor induced by binding of their cognate agonists and antagonists . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Comparable fragments of the androgen receptor ( AR ) ( amino acids 540 607 ) and of the glucocorticoid receptor ( GR ) ( amino acids 412 515 ) were expressed in E . coli as fusion proteins with protein A . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Collectively , androgen receptor binds to DNA with properties similar to , but not identical with , those of glucocorticoid receptor , indicating that regions outside the DNA binding domain are important to ensure androgen specificity of transcriptional regulation . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The ARE specificity of In 1c observed in CV 1 cells was diminished in PC 3 and HeLa cells transiently cotransfected with an androgen receptor or glucocorticoid receptor expression vector together with an In 1c reporter vector ; however , the ARE activity of In 1c was greater than its GRE activity in these cell lines . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Association of the 90 kDa heat shock protein ( HSP 90 ) is required for the high affinity ligand binding of the glucocorticoid receptor ( GR ) , but not for that of the androgen receptor [ Ohara Nemoto , Y . , Nemoto , T . , & Ota , M . ( 1991 ) J . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Multiple nonreceptor factors are involved in androgen specificity , with respect to both the elevation of androgen receptor activity and the inactivity of glucocorticoid receptor ( GR ) , since clustered base changes at any of several sites reduce or abolish androgen induction and do not increase glucocorticoid response . ^^^ These HRE sequence effects on expression correspond in a qualitative manner with receptor binding , i . e . , GR shows a threefold difference in affinities for HREs amongst which androgen receptor does not discriminate . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The 19 nonsteroid , RU 486 , has the ability to bind strongly to the progesterone and glucocorticoid receptor and , less strongly , to the androgen receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
To study the possible structural impact of these mutations , three dimensional models of the normal androgen receptor and of each mutant were built by homology with the glucocorticoid receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In contrast , one element ( 5 ' GGTTCTTGGAGTACT 3 ' ) which was recently described in the promoter region of the probasin gene selectively interacts with the DNA binding domain of the androgen receptor and not with that of the glucocorticoid receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
To better understand the contribution of the GR N terminal transactivation domain in mediating murine thymocyte apoptosis , we stably transfected GR , GR variants , and the androgen receptor ( AR ) into receptor negative S 49 murine thymoma cells . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Human preadipocytes contained glucocorticoid receptor ( GR ) mRNA and androgen receptor ( AR ) mRNA , whereas we were unable to detect oestrogen receptor ( ER ) mRNA and progesterone mRNA in human preadipocytes . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Binding of glucocorticoid receptor or androgen receptor DNA binding domains to the hormone response element , visualized by gel mobility shift , was unaffected in the proximal binding site mutant , markedly decreased in the distal binding site mutant , and abolished in the double mutant . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Both androgen receptor and glucocorticoid receptor are able to induce prostate specific antigen expression , but differ in their growth stimulating properties of LNCaP cells . ^^^ Androgen receptor positive LNCaP cells were stably transfected with a rat glucocorticoid receptor ( GR ) expression plasmid . ^^^ Transfection experiments with the newly derived cell lines showed that , like androgen receptor , GR can induce activity of a prostate specific antigen promoter fragment linked to the luciferase gene . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Cortisol effects are mediated via a glucocorticoid receptor , and testosterone effects via an androgen receptor , the density of which appears to be higher in visceral than subcutaneous adipose tissue . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Interactions of GRIP 1 with the estrogen receptor were more strongly affected by mutations in NR Box 2 , whereas interactions with the androgen receptor and glucocorticoid receptor were more strongly affected by NR Box 3 mutations . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
RESULTS : cDNA fragments for alpha estrogen receptor and androgen receptor but not for beta estrogen receptor , progesterone receptor , and glucocorticoid receptor were amplified from CRL 5813 cells . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We examined the 500 bp upstream of exon 1 in all three H . burtoni genes and identified putative binding sites for glucocorticoid receptor , androgen receptor , and progesterone receptor , as well as the transcription factors Ap 1 and Sp 1 . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In this context ARA 70 , previously called RFG and ELE 1 , has been described as a putative coactivator that specifically enhances the activity of the androgen receptor ( AR ) but not that of the glucocorticoid receptor ( GR ) , the progesterone receptor , or the estrogen receptor ( ER ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Here we report that , in addition to NID , another region of coactivator GRIP 1 ( amino acids 1011 1121 ) , called the auxiliary NID ( NIDaux ) , is required in vitro and in vivo for efficient interaction with a subset of NRs , including the glucocorticoid receptor ( GR ) , androgen receptor , and retinoic acid receptor alpha . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In addition , band shift assays demonstrated that although the synthetic glucocorticoid receptor , GR DNA binding domain ( GR DBD ) , and the synthetic androgen receptor , AR 2 , could interact with the TAT GRE ( dissociation constants Kd of 63 . 9 and 14 . 1 respectively ) , only AR 2 but not GR DBD binding could be detected on ARBS 1 and ARBS 2 . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Swapping of different fragments between the androgen and glucocorticoid receptor DNA binding domains demonstrates that ( 1 ) the first Zn finger module is not involved in this sequence selectivity and ( 2 ) that residues in the second Zn finger as well as a C terminal extension of the DNA binding domain from the androgen receptor are required . ^^^ The glucocorticoid receptor requires 12 C terminal amino acids for high affinity DNA binding , while the androgen receptor only involves four residues . ^^^ Our data demonstrate that the mechanism by which the androgen receptor binds selectively to the PB ARE 2 is different from that used by the glucocorticoid receptor to bind a consensus response element . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Here we report that the C terminal region of p 160 coactivators glucocorticoid receptor interacting protein 1 ( GRIP 1 ) , steroid receptor coactivator 1 ( SRC 1a ) , and SRC 1e binds the N terminal AF 1 activation function of the androgen receptor ( AR ) , and p 160 coactivators can thereby enhance transcriptional activation by AR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We demonstrate that this element displays selectivity for the androgen receptor as opposed to glucocorticoid receptor both in in vitro binding assays and in transfection experiments . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
However , physiologically relevant binding to the POU domain appeared to be a property restricted to only a few nuclear receptors as only GR , progesterone receptor ( PR ) , and androgen receptor ( AR ) , were found to interact physically and functionally with Oct 1 and Oct 2 in transfected cells . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
This is confirmed by the fact that several imperfect direct repeats of the 5 ' TGTTCT 3 ' core recognition sequence are recognized by the androgen receptor and not by the glucocorticoid receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
PNRC was also found to interact with the ligand binding domains of all the nuclear receptors tested including estrogen receptor ( ER ) , androgen receptor ( AR ) , glucocorticoid receptor ( GR ) , progesterone receptor ( PR ) , thyroid hormone receptor ( TR ) , retinoic acid receptor ( RAR ) , and retinoid 10 receptor ( RXR ) in a ligand dependent manner . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Overexpression of the human homologue of RDI 1 , Rho GDIalpha , increases ERalpha , ERbeta , androgen receptor , and glucocorticoid receptor transcriptional activation in mammalian cells but not activation by the unrelated transcription factors serum response factor and Sp 1 . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Functional interaction of human Cdc 37 with the androgen receptor but not with the glucocorticoid receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Although the androgen receptor ( AR ) and the glucocorticoid receptor ( GR ) bind the same consensus DNA sequence , androgen specific responses can be achieved by non conventional androgen response elements ( AREs ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The results indicate that the androgen receptor activation function 2 interacts specifically and with greater avidity with the single FXXLF motif than with the LXXLL motif region of p 160 coactivators , whereas this region of the glucocorticoid receptor interacts preferentially with the LXXLL motifs . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Androgen receptor ( AR ) and glucocorticoid receptor ( GR ) influence distinct physiologic responses in steroid responsive cells despite their shared ability to selectively bind in vitro to the same canonical DNA sequence ( TGTTCT ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The derivative of PF1092C , CP 8481 , ( ( 4aR , 5R , 6R , 7S ) 6 ( 2 furancarbonyloxy ) 7 hydroxy 4a , 5 , 6 , 7 tetrahydro 3 , 4a , 5 trimethylnaphtho [ 2 , 3 b ] furan 2 ( 4H ) one ) possessed better affinity for both progesterone receptors and showed less cross reactivity for other steroid receptors , such as rat androgen receptor , human glucocorticoid receptor , and human estrogen receptor , and was a more potent modulator of the progesterone receptor than PF1092A . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
GT 198 potently stimulated transcription mediated by estrogen receptor alpha and beta , thyroid hormone receptor beta 1 , androgen receptor , glucocorticoid receptor , and progesterone receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Both fetal and adult precursors contained glucocorticoid receptor transcripts , but only adult precursors expressed estrogen receptor alpha and beta together with the androgen receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
It was reported earlier that Hsp 90 might not be as important for the androgen receptor ( AR ) activity as for the glucocorticoid receptor ( GR ) and the progesterone receptor ( PR ) activities . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We have examined the ability of PCBs to interfere with transcriptional activation of the androgen receptor ( AR ) and glucocorticoid receptor ( GR ) in an in vitro transcription based reporter assay system . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In transient transfection experiments using chimeric receptors , the inability of the glucocorticoid receptor to transactivate via the slp ARU as well as the isolated slp HRE 2 was rescued by the replacement of its DNA binding domain with that of the androgen receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We demonstrate that while the DNA binding domain of the oestrogen receptor is unable to dimerize on direct repeats , dimeric binding can be rescued by replacing the second Zn finger and part of the hinge region by the corresponding fragment of the androgen receptor , but not the glucocorticoid receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
RanBPM , a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The suppression of TR 4 mediated transactivation is selective because TRA 16 shows only a slight influence on the transactivation of androgen receptor , glucocorticoid receptor , and progesterone receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
However , ginsenoside Rb 1 failed to activate the glucocorticoid receptor , the retinoic acid receptor , or the androgen receptor in CV 1 cells transiently transfected with the corresponding steroid hormone receptors and hormone responsive reporter plasmids . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
CP 8668 showed no significant affinity for human glucocorticoid receptor or human estrogen receptor and very weak affinity for rat androgen receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The observed effects of progestins and antiprogestins on C 4I cells were also presented in C33A cells ( 16 % androgen receptor positive ) and Me 180 cells ( 22 % progesterone receptor positive , 9 % androgen receptor positive and 17 % glucocorticoid receptor positive ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Expression of androgen receptor and glucocorticoid receptor ( GR ) but not progesterone receptor was detected . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
However , ginsenoside Rh 1 failed to activate the glucocorticoid receptor , the androgen receptor , or the retinoic acid receptor in CV 1 cells transiently transfected with the corresponding steroid hormone receptors and hormone responsive reporter plasmids . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
LRP 16 promoter controlled luciferase expression vector ( pGL 3 S ( 0 ) ) was co transfected with various nuclear receptors , including estrogen receptor alpha and beta ( ERalpha and ERbeta ) , glucocorticoid receptor alpha ( GRalpha ) , androgen receptor ( AR ) and peroxisome proliferator activated receptor gamma and alpha ( PPARgamma and PPARgamma ) into COS 7 cells , and the relative luciferase activity was measured using Dual luciferase report assay systems . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We report that cisplatin dose dependently inhibited transcriptional activity of the androgen receptor and the glucocorticoid receptor ( GR ) in transient reporter assays . ^^^ Other Hsp 90 regulated proteins , i . e . the phosphokinases raf 1 , lck , and c src , were not affected , indicating a specific functional interference of cisplatin with the steroid receptors GR and androgen receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Liganded androgen receptor repressed TGF beta transactivation , whereas mineralocorticoid receptor did not , and studies with rat GR mineralocorticoid receptor chimeras confirmed that the GR C terminal domains were required for repression . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Paxillin functions as a coactivator for androgen receptor and glucocorticoid receptor , but not estrogen receptor alpha , similar to its close relative Hic 5 / ARA55 . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Androgen receptor ( AR ) , as well as glucocorticoid receptor ( GR ) , is unique since most , if not all , of its activities are mediated via the constitutive activity of the activation function 1 ( AF 1 ) function . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
As an alternative , non transcriptional approach , we constructed fluorescent cellular sensors by expressing yellow fluorescent protein ( YFP ) fused to the ligand binding domains ( LBDs ) of estrogen receptor alpha ( ERalpha ) , estrogen receptor beta ( ERbeta ) , androgen receptor ( AR ) , and the glucocorticoid receptor ( GR ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The purpose of the current study was to establish the role of the glucocorticoid receptor ( GR ) and androgen receptor ( AR ) transcription factors in the transactivation of rat aryl sulfotransferase ( SULT1A1 ) gene transcription and to identify the functional hormone responsive element ( s ) in the SULT1A1 gene . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Observations reported here reveal that estrogen receptors alpha and beta ( ERalpha and ERbeta ) , androgen receptor , and glucocorticoid receptor bind in vitro to vinexin alpha , a multiple SH 3 motif containing protein associated with the cytoskeleton . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Asoprisnil demonstrates a high degree of receptor and tissue selectivity , with high binding affinity for PR , moderate affinity for glucocorticoid receptor ( GR ) , low affinity for androgen receptor ( AR ) , and no binding affinity for estrogen or mineralocorticoid receptors . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Immunohistochemistry was used to detect the expression of progesterone receptor , estrogen receptor , glucocorticoid receptor ( GR ) , and androgen receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Among the three steroid receptors examined , androgen receptor ( AR ) and glucocorticoid receptor ( GR ) mRNAs were significantly down regulated ( 29 % and 35 % , respectively ) in the testis , but there was no change in estrogen receptor alpha . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The coactivation of Cdc25B can be extended to the glucocorticoid receptor ( GR ) , progesterone receptor ( PR ) , and androgen receptor ( AR ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In addition to its role in focal adhesion signaling , Hic 5 acts in the nucleus as a coactivator for some steroid hormone receptors such as the glucocorticoid receptor ( GR ) and androgen receptor ( AR ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We characterized the specifically androgen regulated gene ( SARG ) , which is expressed in the androgen receptor ( AR ) and glucocorticoid receptor ( GR ) positive cell line lymph node carcinoma of the prostate 1F5 ( LNCaP 1F5 ) . ^^^ ARE SARG+4 . 6 was able to bind to the androgen receptor , but not to the glucocorticoid receptor , correlating with its androgen specific activity in transfections . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the expression of glucocorticoid receptor ( GR ) , oestrogen receptor ( ER ) , progesterone receptor ( PR ) and androgen receptor ( AR ) in nasal mucosa . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Expression of androgen receptor ( AR ) , estrogen receptor alpha ( ERalpha ) and beta ( ERbeta ) , progestin receptor ( PR ) and glucocorticoid receptor alpha and beta was investigated by the means of RT PCR , immunocytochemistry , ligand binding or Western blot . 22RV1 cells were proved to express androgen receptor and less glucocorticoid receptor beta on mRNA level . ^^^ The confirmed mutation of the androgen receptor at codon H 874 slightly apart from the steroid binding pocket seemed not to cause alteration of natural steroid hormone binding . mRNA expression of all progestin and estrogen receptor isoforms as well as glucocorticoid receptor alpha could not be detected . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Almost devoid of affinity to the androgen receptor , as derived from investigations in the mouse fibroblast cell line 29 + / GR + , RUM is rapidly metabolised to the potent antiandrogen RU 58841 by cultured human foreskin fibroblasts and keratinocytes , male occipital scalp skin dermal papilla cells , and by cells of the sebaceous gland cell line SZ 95 . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The 11beta benzaldoxime substituted SPRMs showed high PR binding affinities , reduced glucocorticoid receptor affinities compared with the antiprogestin mifepristone , marginal androgen receptor binding affinities , and no binding to estrogen receptors . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The multifunctional oncoprotein beta catenin interacts with the activation function 2 domain of androgen receptor ( AR ) to stimulate androgen receptor transcriptional activity , increase sensitivity , and broaden specificity of ligand interactions . beta Catenin interacts with androgen receptor in close proximity to the binding groove for P 160 coactivators such as transcriptional intermediary factor 2 ( TIF 2 ) / glucocorticoid receptor interacting protein 1 ( GRIP 1 ) . beta Catenin can also bind directly to TIF2 / GRIP1 . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : Tumor cell lines from 19 patients with advanced epithelial ovarian cancer were analyzed for glucocorticoid receptor , estrogen receptor , progesterone receptor , and androgen receptor expression . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
When the human mineralocorticoid receptor ( hMR ) was cloned and sequenced by the Evans laboratory , its close homology with the human glucocorticoid receptor ( hGR ) was noted ; subsequently , on the basis of its higher sequence similarity to the GR than to the progesterone receptor ( PR ) or androgen receptor ( AR ) , MR and GR have commonly been considered to share an immediate common ancestral `` corticoid receptor . ' ' When , however , homology is determined for the full length receptor , or helices 3 / 4 / 5 / 12 , MR is least like any of the other three receptors ; for the ligand binding domain , AR is clearly the least homologous . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The GREF matrix family represents androgen receptor , glucocorticoid receptor and progesterone receptor binding sites and the GATA matrix family represents GATA binding protein 1 6 binding sites . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
This revealed the presence of mRNA for the androgen receptor ( AR ) and glucocorticoid receptor ( GR ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
All members , including the glucocorticoid receptors ( GR ) , mineralocoroticoid receptors ( MR ) , estrogen receptors ( ER ) , progesterone receptors ( PR ) and androgen receptor ( AR ) , mediate the expression of a gene by binding to hormone responsive elements ( HREs ) as dimmers in a ligand dependent manner . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
One binding partner identified was Hic 5 ( also known as ARA 55 ) , a multiple LIM domain containing protein implicated in focal adhesion signaling and the regulation of specific nuclear receptors , including the androgen receptor and the glucocorticoid receptor ( GR ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Yellow fluorescent protein ( YFP ) N CoR was distributed as intranuclear discrete dots , while coexpression of androgen receptor ( AR ) , glucocorticoid receptor alpha , and estrogen receptor alpha ligand dependently triggered redistribution of YFP N CoR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Cytoplasmic receptors to androgens ( AR ) , estrogens ( ER ) , progesterone ( PR ) and glucocorticoids ( GR ) were studied in tumors and normal tissue of the testis in dogs . ^^^ Malignant seminomas and Sertoli cell tumors were characterized by higher occurrence and levels of AR , GR and PR than their benign counterparts . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Ancillary studies were carried out to exclude a potential overestimation of the AR content by interference with other steroid receptors , namely , progesterone ( PgR ) or glucocorticoid ( GcR ) receptors . ^^^ Results showed that the interaction by PgR or GcR upon AR measurement was not relevant . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Receptors were measured 3 weeks after primary culture in glial cells cultured in the presence or not of 50 nM estradiol and we have identified progesterone , glucocorticoid , estrogen , and androgen receptors ( PR , GR , ER and AR ) , but only PR was inducible by the estrogen treatment . ^^^ Specific binding sites for PR , GR , ER and AR were measured by whole cell assays after labeling cells with , respectively , [ 3H ] R 5020 , [ 3H ] dexamethasone , [ 3H ] OH tamoxifen or [ 3H ] R 1881 . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The enzyme activity spectra ( AR , SDH , GR , GPX , PFK , ALD , GAP DH , and LDH ) showed region related patterns , which could not be detected with analysis of the total lens . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Steroid hormone receptors including androgen receptor ( AR ) , glucocorticoid receptor ( GR ) , progesterone receptor ( PR ) , and mineralocorticoid receptor ( MR ) recognize and bind to identical consensus hormone response elements ( HREs ) , which consist of two hexameric half sites ( 5 ' AGAACA 3 ' ) arranged as inverted repeats with a 3 bp spacer . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
These constructs can be activated either by both the glucocorticoid receptor ( GR ) and the androgen receptor ( AR ) ( TAT GRE4x Luc and MMTV Luc ) or selectively by the AR ( Pem Luc ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
This study was designed to assess the multiple steroid receptor mediated activities of a series of synthetic ' progestins ' on breast cancer cell growth , using the human ZR 75 1 cell line which possesses functional estrogen ( ER ) , androgen ( AR ) , and glucocorticoid ( GR ) receptors as well as progesterone ( PgR ) receptors . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
By comparison with the previously published structure of Ar ( p ) isolated from Saccharomyces cerevisiae initiator tRNA ( Met ) , the ( 1 ' ' 2 ' ) glycosidic bond in Gr ( p ) has been postulated to have a beta spatial conformation . ^^^ The modified nucleotide Gr ( p ) is located at position 64 in the tRNA ( Met ) molecules , i . e . at the same position as Ar ( p ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Receptors of estrogens ( ER ) , progesterone ( PR ) , glucocorticoids ( GR ) and androgens ( AR ) were assayed in samples obtained from 142 patients with malignant melanoma . ^^^ GR were observed most often ( 57 % of cases ) , the percentage being significantly lower for ER ( 25 % ) and PR ( 18 % ) and extremely low for AR ( 4 % ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We investigated the effect of c Fos and / or c Jun co expression on transcription activation by the progesterone ( PR ) , glucocorticoid ( GR ) or androgen ( AR ) receptors using three different reporter genes and four different cell lines . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
A nuclear targeting signal similar in sequence and position to the glucocorticoid receptor and homologous to the SV 40 large T antigen was required for androgen induced nuclear uptake of wild type AR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Although nuclear GR never approached the normal population of nuclear androgen receptors ( AR ; approximately 16000 molecules / nucleus ) , the selective rise in chromatin associated receptors ensured that almost 60 % of chromatin sites remained occupied . ^^^ GR associated with prostate nuclear structures in a similar manner to AR , and exogenous GR bound saturably and with high affinity ( Kd 100 pmol / l ) to a similar number of sites as did AR . ^^^ In DNA cellulose competition analyses , synthetic oligonucleotides containing glucocorticoid response elements or putative androgen response elements competed similarly against immobilized non specific DNA for both AR and GR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Androgen ( AR ) , oestrogen ( ER ) , progesterone ( PR ) and glucocorticoid ( GR ) receptors were assayed in the high speed soluble fraction and in the nuclear extract from 73 carcinomas of the larynx . ^^^ Forty one , 26 , 15 , and 13 tumours expressed cytosolic GR , ER , AR , and PR , respectively , while 33 , 26 , 13 and 13 biopsies were nuclear positive for GR , ER , AR , and PR , respectively . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In addition , a chimeric receptor protein containing the amino terminus and DNA binding domains of AR fused to the previously defined ligand domain of the glucocorticoid receptor was found to be fully functional based on dexamethasone induced chloramphenicol acetyltransferase activity . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Receptors to estrogens ( ER ) , progesterone ( PR ) , glucocorticoids ( GR ) and androgens ( AR ) were assayed in 44 lung cancer patients to evaluate hormonal sensitivity of tumor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Untransformed cytosol receptors for progesterone ( PR ) , androgen ( AR ) , estrogen ( ER ) , and glucocorticosteroid ( GR ) in rabbit tissues contain a 59 kDa protein ( p 59 ) ( Tai , P . ^^^ In the present study , receptors from calf uterus ( PR , AR , ER , and GR ) and from human breast cancer MCF 7 cells ( PR and GR ) were also shown to be comprised of hsp 90 and p 59 . ^^^ In 0 . 4 M KCl , tungstate stabilized ( but not molybdate stabilized ) PR , AR , ER , and GR retained hsp 90 , but lost p 59 . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In an attempt to learn whether modulation of steroid hormone receptor by arachidonate is generalized or not , the arachidonate effect was examined in cytosol estrogen ( ER ) , progestin ( PR ) , androgen ( AR ) and glucocorticoid receptors ( GCR ) from the central and peripheral tissues of rats by sucrose density gradient centrifugation , and gel filtration on LH 20 columns or dextran coated charcoal absorption . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Cytosols from 12 nasopharyngeal angiofibroma tissues were analyzed for the presence of estrogen ( ER ) , progesterone ( PR ) , androgen ( AR ) , and glucocorticoid ( GR ) receptors , by using a dextran charcoal assay . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Glucocorticoid and androgen receptors ( GR , AR ) were determined both on tissue samples ( 7 cases ) and on five out of the seven cell cultures obtained by tumours . ^^^ GR and AR were present respectively in 5 and in 4 out of the tumour specimens assayed and in 4 / 5 and 2 / 3 of the tested cell cultures . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Accordingly , mRNA levels in total RNA extracted from 13 human breast cancer cell lines were measured by Northern analysis employing complementary DNA probes for the human oestrogen ( ER ) , progesterone ( PR ) , androgen ( AR ) , vitamin D 3 ( VDR ) and glucocorticoid receptors ( GR ) . ^^^ ER , PR and AR mRNAs were negatively associated with GR levels ( p less than or equal to 0 . 012 ) , while ER and AR mRNA levels were negatively correlated with mRNA for the epidermal growth factor receptor . ^^^ Our data demonstrate the coordinate expression of ER , PR and AR genes , and an inverse relationship between sex steroid hormone receptor and GR gene expression in human breast cancer cell lines . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Mouse L 929 fibroblasts contain androgen ( AR ) , estrogen ( ER ) and glucocorticosteroid receptors ( GR ) . ^^^ Cyproterone acetate , tamoxifen and RU 486 have specific affinity for AR , ER and GR , respectively . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The relative binding affinities of 48 steroids for four classes of hormone receptor ( progestin , PR ; androgen , AR ; glucocorticoid , GR ; mineralocorticoid , MR ) have been analyzed by correspondence analysis . ^^^ Distribution maps visualizing the results of the mathematical analysis revealed that the majority of the test steroids were within the zone of influence of AR and PR and had limited affinity for GR and MR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Estrogen ( ER ) , progesterone ( PR ) , glucocorticoid ( GR ) and androgen ( AR ) receptors were assayed in tumor samples from 8 cases of male breast cancer ( MBC ) and 20 cases of male gynecomastia . ^^^ Positive GR and AR values were also detected in 75 % of MBC cases . ^^^ With gynecomastic tissue , the proportion of receptor positive patients was 20 % ER , 20 % PR , 20 % AR , and 45 % GR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Estrogen ( ER ) , progesterone ( PR ) , androgen ( AR ) and glucocorticoid ( GR ) receptor levels were assayed in 70 malignant epithelial ovarian tumors from untreated patients and in 23 malignancies from those receiving preoperative chemotherapy . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
No correlations between ER / PR status and other parameters such as age , sex , stage , androgen and glucorticoid receptors ( AR , GR ) , lymphocytic count or plasma estradiol and progesterone levels were noted . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Estrogen ( ER ) , progesterone ( PR ) , androgen ( AR ) and glucocorticoid receptors ( GR ) were evaluated in thymus cytosols from 15 myasthenia gravis ( MG ) patients , using a dextran charcoal assay . ^^^ ER was found in 40 % , PR and AR in 53 % and GR in 100 % of MG thymi . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Estradiol ( ER ) , progesterone ( PR ) , androgen ( AR ) and glucocorticoid receptor ( GR ) levels were assayed in 25 breast cancer tumors . ^^^ This micromethod was highly correlated with the standard method : ER = 0 . 985 ( P less than 0 . 001 ) ; PR = 0 . 999 ( P greater than 0 . 001 ) ; AR = 0 . 989 ( P less than 0 . 001 ) ; GR = 0 . 867 ( P less than 0 . 001 ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We have examined in the bursa of Fabricius of Obese strain ( OS ) chickens , which spontaneously develop autoimmune thyroiditis , as well as in their healthy counterparts androgen ( AR ) , estrogen ( ER ) , progestin ( PR ) and glucocorticoid ( GR ) receptors in an attempt to elucidate possible further pathomechanisms , namely at the target site of steroid hormones . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Cytosolic glucocorticoid ( GR ) and androgen receptors ( AR ) were evaluated at varying time intervals ( 1 28 days ) post denervation in rat bulbocavernosus / levator ani muscles and the receptor content in the unilaterally denervated muscles compared to the contralateral innervated muscles . ^^^ Rats were adrenalectomized 3 days prior to GR or castrated 24 h prior to AR determinations . ^^^ Lowered AR were noted in the denervated muscles during very early time periods post denervation while increased GR were not observed until later . ^^^ The GR to AR ratio was consistently higher in denervated muscles regardless of the basis of comparison , however . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Cytosolic estrogen ( ER ) , progesterone ( PR ) , androgen ( AR ) and glucocorticoid receptors ( GR ) were evaluated in 10 meningiomas using a dextran charcoal coated method . ^^^ GR and AR were present in moderate levels , in 70 % of the tumors . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We have determined that a significant incidence of specific high affinity receptors for androgen ( AR ) , estrogen ( ER ) , and glucocorticoid ( GR ) is present in normal adult human lung and bronchogenic carcinoma cytosols . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Alterations in cytosolic glucocorticoid ( GR ) and androgen receptors ( AR ) in atrophic rat bulbocavernosus / levator ani muscles ( BCLA ) were investigated . ^^^ The data reflect differences in the behaviour of GR and AR in the atrophic BCLA and suggest a relative increase in sensitivity to glucocorticoids compared to androgens in the DEN muscle . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Progestin , estrogen , androgen , glucocorticoid as well as mineralocorticoid receptors ( PR , ER , AR , GR and MR , respectively ) were all evaluated with specific synthetic radioligands ( biochemical assays ) in 25 meningiomas , 9 gliomas and 4 brain metastases . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The cytoplasmic receptors for 17 beta estradiol ( ER ) , 5 alpha dihydrotestosterone ( AR ) , progesterone ( PR ) , and cortisol ( GR ) have been quantified in 36 specimens from the human ovary ( 13 disease free , 5 benign , and 18 malignant ) by a dextran coated charcoal ( DCC ) technique . ^^^ The occurrence of receptor positive biopsies were : ER 46 % , AR 85 % , PR 54 % , GR 92 % , in normal tissue ; ER 40 % , AR 100 % , PR 20 % , GR 50 % , in benign tumors ; and ER 67 % , AR 72 % , PR 50 % , GR 88 % , in malignant lesions . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In recent years experiments performed in animals showed that : 1 ) endogenous steroid hormones cross the blood brain barrier : 2 ) radiolabelled steroid hormones bind in specific areas of the CNS ; 3 ) all five classes of steroid receptors , i . e . oestrogen , progesterone , androgen , glucocorticoid and mineralocorticoid receptors ( OR , PR , AR , GR , MR ) , are present in brain tissues , especially in the hypothalamus and the limbic system ; 4 ) the interaction of steroid hormones and specific receptors induces the synthesis of proteins in the CNS ; 5 ) finally , in situ metabolism of steroid hormones has been evidenced by the presence of specific enzymes . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Cytosolic estrogen ( ER ) , progesterone ( PR ) , androgen ( AR ) , and glucocorticoid ( GR ) receptors were evaluated in 6 meningiomas and 12 gliomas ( 6 astrocytomas and 6 glioblastomas ) using a dextran coated charcoal method . ^^^ On the other hand , positive PR , GR , and AR levels were detectable in 100 % ( six ) of the meningiomas . ^^^ PR was present in 50 % ( six ) , AR in 42 % ( five ) , and GR in 58 % ( seven ) of the gliomas . ^^^ PR , GR , and AR values were statistically higher in meningiomas than in neuroepithelial tumors . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Nuclear transfer of androgen receptors ( AR ) and glucocorticoid receptors ( GR ) was determined in cultured genital skin fibroblasts from 10 normal controls and eight patients with abnormalities of the external genitalia . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The androgen ( AR ) and glucocorticoid receptors ( GR ) are related ligand activated transcriptional regulators which bind the same cis acting element and are coexpressed in a variety of cell types . ^^^ Prostate epithelial cell growth is sensitive to androgens , but is not affected by glucocorticoids , even though both AR and GR are expressed in these cells . ^^^ In this study , we compared the abilities of AR and GR to enhance transcription of several different reporter genes regulated by simple ( i . e . , noncompsite ) hormone response elements ( HREs ) in prostate and nonprostate cell lines . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We recently identified a protein , designated receptor accessory factor ( RAF ) , that interacts directly with and enhances the DNA binding of androgen ( AR ) and glucocorticoid ( GR ) receptor peptide fragments . ^^^ In addition , the interaction of AR or GR with RAF was competed by insulin and bacitracin , a competitive inhibitor of IDE . ^^^ The interactions of AR and GR with IDE may have important implications for both insulin and steroid mediated signaling . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Twenty two colorectal carcinomas were examined for the presence of estrogen ( ER ) , progesterone ( PR ) , androgen ( AR ) and glucocorticoid receptors ( GR ) by a charcoal dextran assay . 2 . ^^^ Most tumor biopsies and normal mucosa were completely AR negative , whilst GR was present in a larger fraction ( 63 % ) of tumoral specimens , occurring more commonly in colon than in rectum carcinomas . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Using the mobility shift assay , we have identified a factor that enhances specific DNA binding of truncated rat androgen ( AR ) and glucocorticoid ( GR ) receptors by 25 and 6 fold , respectively , through the formation of heteromeric complexes . ^^^ The interaction of RAF with AR and GR suggests that RAF might influence the ability of these nuclear receptors to activate transcription . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Based on the intensities of ARE binding and lack of binding to an ARE half site , it appears that , unlike the glucocorticoid receptor , AR binds DNA primarily as a dimer . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
With the radioligand binding assay , the maximal binding capacity ( Bmax ) and affinity ( Kd ) of alpha , beta adrenoceptors ( alpha AR , beta AR ) in the lung membrane and glucocorticoid receptor ( GCR ) in the lung cytoplasma of rats with experimental respiratory distress syndrome ( RDS ) induced by oleic acid have been measured . ^^^ Meanwhile , the content of beta AR and GCR decreased continuously , the Bmax at the same time were 364 + / 18 , 307 + / 55 , 240 + / 66 and 146 + / 28 , 153 + / 37 , 150 + / 32 fmol / mg protein respectively , significantly lower than their normal value ( 490 + / 61 , 227 + / 14 fmol / mg protein , n = 6 10 , P < 0 . 01 ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The cytoplasmic concentrations of ER , AR , PR , and GR were determined in 124 specimens of normal and abnormal endometrium and other uterine human tissues by the DCC technique . ^^^ In the endometrial carcinoma group , we observed that pretreatment with MAP leads to low cellularity , higher amount of AR , lower amounts of detectable ER , GR , and PR : the last receptor was almost always absent . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We studied messenger RNA ( mRNA ) expressions of receptors for glucocorticoid ( GR ) , thyroid hormone ( TR ) , androgen ( AR ) , and estrogen ( ER ) and their changes with age in the hippocampal subregions in postmortem human brain . ^^^ The ratio of mRNA containing neuron density to total neuron density significantly decreased with age for GR in CA 1 and CA 3 , and for AR in CA 1 . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Like AR , the glucocorticoid receptor was able to stimulate PSA promoter activity . ^^^ Both the AR and glucocorticoid receptor were 20 100 fold more active on ARR PSA and ARR thymidine kinase promoter constructs in LNCaP cells than in other cell types ( COS , HeLa , Hep3B , and T47D cells ) , indicating ( prostate ) cell specificity . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Androgen , mineralocorticoid and glucocorticoid receptors ( AR , MR and GR , respectively ) are ligand activated transcription factors that alter gene expression and have a wide variety of effects in the central nervous system . ^^^ High levels of AR , MR and GR mRNA have been found in the CA 1 pyramidal cell region of the rat hippocampus and all 3 of these proteins bind to a similar hormone response element in DNA suggesting the possibility of common receptor function or cross talk between these receptors at the level of transcription . ^^^ To begin to investigate this hypothesis , we examined the regulation of AR , MR and GR mRNA expression in the rat hippocampus following treatment with androgens in combination with gonadectomy and / or adrenalectomy . ^^^ GR , MR and AR mRNA were measured in the hippocampal subfields using in situ hybridization . ^^^ No changes in GR mRNA were observed in the CA 3 region or dentate gyrus , where AR expression is low or absent . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In COS 1 cells co transfected with androgen and glucocorticoid receptor cDNAs , dexamethasone mimicked the action of androgen in down regulating AR mRNA . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Site directed mutants were tested to identify elements affecting differential response of androgen or glucocorticoid receptors ( AR , GR ) . ^^^ While most mutations of C ' delta 2 affected induction by either steroid similarly , disruptions of the consensus HRE or an octamer like sequence were more severe for GR than AR activity . ^^^ In DNase 1 footprinting , full length AR and GR bound similarly to the consensus HRE but dissimilarly to nonconsensus sites . ^^^ This dissection of C ' delta 2 and C ' delta 9 in vitro reveals subtle distinctions in AR and GR interactions that may underlie specific hormonal response in vivo . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We have used artificial and natural mutant ARs from patients with androgen resistance to study their effects on dominant negative activity on wild type AR , GR , and PR function on mouse mammary tumor virus ( MMTV ) and tyrosine aminotransferase ( TAT ) promoters . ^^^ Surprisingly , wild type AR , which had approximately 20 % of the maximal transcriptional activity of GR on the MMTV promoter , also had dominant negative activity on dexamethasone regulated transcription mediated by GR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Reperfusion was carried out either abruptly ( AR ) or gradually ( i . e . , perfusion pressure stepwise increased from 40 to 75 mmHg within 30 min GR ) . ^^^ GR resulted in a significant improvement of percentage recovery of left ventricular systolic pressure as compared to AR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
A wide range of physiological and molecular biological evidence suggests that the receptors that mediate these effects , the androgen and glucocorticoid receptors ( AR and GR , respectively ) , influence each other ' s transcriptional activity . ^^^ We now show that coexpressed AR and GR indeed do interact at the transcriptional level and that this interaction is correlated with their ability to form heterodimers at a common DNA site , in vitro and in vivo . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The antibody reacted specifically with PR , but did not cross react with ER , AR , or GR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Intron 1 contains a 130 base pair complex response element ( D 2 ) that binds androgen ( AR ) and glucocorticoid receptor ( GR ) but transactivates only with AR in transient cotransfection assays in CV 1 cells using the reporter vector D 2 tkCAT . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We have found that overexpression of androgen ( AR ) , glucocorticoid ( GR ) , mineralocorticoid , and progesterone receptors in transiently transfected COS 1 cells induced HSF activity . ^^^ As overexpression of hsp 70 can eliminate HSF activation by AR , GR , and progesterone receptors , we favor the view that HSF activation can result from the sequestration , by steroid receptor ligand binding domains , of a negative regulator of HSF , such as hsp 70 or an hsp 70 associated protein . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The diagnosis : Stenosis aorte valvularis gr . majoris , Aorta bivelaris , and Stenosis r . sinistri ar . pulmonalis have been confirmed by the invasive method . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
A consensus glucocorticoid response element ( GRE ) can mediate transactivation by AR and other members of the AR / glucocorticoid ( GR ) / progesterone ( PR ) / mineralocorticoid ( MR ) receptor subfamily . ^^^ DR 1 demonstrated a strong preference for AR binding and transactivation when compared with GR . ^^^ To our knowledge , this is the first observation that a direct repeat of GRE like core motifs functions as a preferred hormone response element within the AR / GR / PR / MR subfamily of nuclear receptors . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In glial cells of the CNS , progesterone , glucocorticoid , estrogen and androgen receptors ( PR , GR , ER , AR ) were demonstrated and of these receptors , only PR was estrogen inducible . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Minor nucleosides found in several eukaryotic initiator tRNASiMet , O beta D ribofuranosyl ( 1 ' ' > 2 ' ) adenosine and guanosine ( Ar and Gr ) , as well as their pyrimidine analogues , were obtained from N protected 3 ' , 5 ' O ( 1 , 1 , 3 , 3 tetraisopropyldisiloxane 1 , 3 diyl ) ribonucle osides and 1 O acetyl 2 , 3 , 5 tri O benzoyl beta D ribofuranose in the presence of tin tetrachloride in 1 , 2 dichloroethane . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Androgen and glucocorticoid receptors ( AR , GR ) recognize a consensus DNA hormone response element ( HRE ) , but they activate target genes with precise specificity , largely dependent on the promoter and cell context . ^^^ We have assessed the role of different receptor domains in hormone specific response by testing chimeras of AR and GR for their ability to activate the androgen specific enhancer of the mouse sex limited protein ( Slp ) gene . ^^^ Activation was not due to differential DNA affinity but rather to the AR DNA binding domain escaping suppression directed at the GR DNA binding domain in this enhancer context . ^^^ These subtle distinctions in AR and GR behavior enforce transcriptional specificity established by the context of nonreceptor factors . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In contrast , loss of pRB activity inhibits AR but not glucocorticoid receptor activity . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Sections of benign prostatic hyperplasia and prostatic carcinoma from each patient were stained with antibodies to AR and GR using an avidin biotin peroxidase technique . ^^^ Nuclear staining intensity and percentage of nuclei stained were summed to obtain AR and GR immunostaining scores . ^^^ There was no relationship by multivariate regression analysis between AR or GR staining and age , serum prostate specific antigen , Gleason grade , or pathological stage . ^^^ In comparison with AR , the greater variability of GR staining in epithelium versus stroma of prostatic carcinoma warrants further study of GR , particularly in the area of stromal epithelial interaction . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The coactivators did not enhance the transcription activity of the progesterone receptor ( PR ) or the glucocorticoid receptor ( GR ) , showing their specificity for the AR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
AR or GR were not detected in tumor samples using biochemical assays . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We examined the interaction between the androgen ( AR ) and glucocorticoid receptor ( GR ) at the transcriptional level using mouse fibroblast cell lines harboring an integrated mouse mammary tumor virus ( MMTV ) promoter . ^^^ Consistent with this , nuclear GR levels dropped by greater than 50 % after Dex treatment whereas the AR was induced fourfold after 24 h of DHT treatment . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The latter inhibitor is more selective than the former because it did not show any inhibitory potency against P 450 aromatase as well as any affinity towards four steroid receptors ( AR , PR , GR , ER ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Here we show that the ARE / GRE can bind the DNA binding domain ( DBD ) of both the androgen ( AR ) and glucocorticoid receptor ( GR ) with a preference for the AR DBD . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We demonstrate that ERalpha , ERbeta and ERbeta 2 preferentially interact with motif 2 while GR , AR , PPARalpha and PPARgamma preferentially interact with motif 4 . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Full length TRAM 1 ( aa 1 1424 ) and the partial ( aa 459 1424 ) were AR and GR coactivators as was SRC 1 . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In addition , BRCA 1 was shown to interact physically with both the AR and the p 160 coactivator , glucocorticoid receptor interacting protein 1 . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Their relative binding potency to progesterone ( PR ) , androgen ( AR ) and estrogen ( ER ) receptors were determined in cell lysates of human breast tumor MCF 7 cells and to glucocorticoid ( GR ) receptors in that of human leukemic IM 9 cells . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
To examine the role of Oct 1 in androgen specific gene activation , we tested the interaction of Oct 1 with AR versus glucocorticoid receptor ( GR ) in vivo and in vitro . ^^^ Oct 1 coimmunoprecipitated from cell lysates with both AR and GR , but significant association with AR required both proteins to be DNA bound . ^^^ AR / GR chimeras revealed that interaction of the N and C termini of AR was required to communicate the DNA bound state that enhances interaction with Oct 1 . ^^^ Protease digestion assays of hormone bound receptors revealed further conformational changes in the ligand binding domain of AR , but not GR , upon DNA binding . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Basal expression of ARR2PBCAT in the nonprostatic COS 1 , MCF 7 , ZR 75 1 , and PANC 1 cell lines was very low ; however , CAT activity could be induced in response to androgens and glucocorticoids when cells were cotransfected with either the AR or GR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
A double stranded radiolabelled oligonucleotide containing this NEP ARR sequence formed DNA protein complex with AR but not GR proteins . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The biological activities of NET , MeNET and their potential metabolites were assessed by in vitro binding , transactivation and proliferation assays on progesterone ( PR ) , androgen ( AR ) , estrogen ( ER ) and glucocorticoid ( GR ) receptors and by in vivo progestagenic McPhail , androgenic Hershberger , estrogenic Allen Doisy tests and combined estrogenic and progestagenic ovulation inhibition tests . ^^^ Binding and transactivation activities of NET for AR ( DHT=100 % ) are 3 . 2 and 1 . 1 % , respectively , for ER none ( E2=100 % ) and for GR below 1 % ( DEX=100 % ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Protein DNA interaction assays revealed two factors binding the 5 ' part of the enhancer that differ widely in abundance between cells showing AR specific activation of the Slp element compared with those that also permit activation by glucocorticoid receptor ( GR ) . ^^^ Although this interaction was equivalent between AML1 / CBFalpha2 and AR or GR , AML3 / CBFalpha1 showed stronger interaction with AR than with GR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Total GCR ( P=0 . 005 ) , alpha / alpha 2 GCR ( P=0 . 005 ) and beta ( 2 ) AR ( P=0 . 03 ) mRNA levels all decreased significantly after intensive insulin treatment . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
A previous study reported that activation of the wild type glucocorticoid receptor ( wtGR ) suppressed the aggregation of expanded polyglutamine proteins derived from AR and huntingtin , whereas a mutant receptor containing an internal deletion , GRDelta 108 317 , increased polyglutamine protein aggregation , in this case primarily within the nucleus . ^^^ In this study , we use these two forms of GR to study expanded polyglutamine AR protein in different cell contexts . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Unlike the steroid hormone receptor coactivator 1 ( SRC 1 ) , beta catenin showed a strong interaction with AR but not with other steroid hormone receptors such as estrogen receptor alpha , progesterone receptor beta , and glucocorticoid receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Since both GR and AR are present in the MDA MB 453 cells , and both receptors can act through the MMTV promoter , compounds that act through either AR or GR activate the MMTV luciferase reporter . ^^^ As expected , AR agonists such as dihydrotestosterone ( DHT ) , and GR agonists such as dexamethasone ( DEX ) , corticosterone , and aldosterone induce luciferase expression at appropriate concentrations . ^^^ To distinguish AR from GR mediated ligands , chemicals were assayed concurrently with the antiandrogen , hydroxyflutamide ( OHF ) , which blocks AR but not GR mediated responses . ^^^ In summary , we have developed a cell line that can be used to screen chemicals , not just for AR but for GR mediated activities as well . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Human breast carcinoma cells ( MDA MB 453 ) containing endogenous copies of the androgen ( hAR ) and glucocorticoid ( GR ) receptors were transduced with replication defective human adenovirus type 5 containing the luciferase ( Luc ) reporter gene driven by the AR and GR responsive glucocorticoid inducible hormone response element found with the mammary tumor virus LTR ( Ad / MLUC7 ) . ^^^ Comparing the two assays , the transduced CV 1 cells were slightly more sensitive to AR mediated responses , but the transduced MDA 453 cells were more responsive to GR agonists . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Androgen and glucocorticoid receptor ( AR , GR ) , two closely related members of the nuclear receptor superfamily , can recognize a similar cis acting DNA sequence , or hormone response element ( HRE ) . ^^^ The AR gene itself is regulated by AR but not GR in a variety of cell types , including osteoblast like cells , as shown here . ^^^ A panel of AR / GR chimeric receptors was used to test which AR domains ( amino terminal , DNA binding or ligand binding ) confer androgen specific regulation of the 350 bp enhancer . ^^^ Further , a constitutively active AR consisting of only the AR amino terminus and DNA binding domain ( AA phi ) retained the capacity to activate the internal responsive region , unlike a constitutively active chimera harboring the GR amino terminus and AR DNA binding domain ( GA phi ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Substitution at the C 10 position of the tetracyclic core with linear , two atom appendages ( OCH ( 3 ) , OCF ( 2 ) H , NHMe , SMe , CH=CH ( 2 ) , Ctbd 1 ; CH , CH ( 2 ) OH ) provided molecules of high affinity ( K ( 1 ) = 2 8 nM ) for the human glucocorticoid receptor ( hGR ) with limited cross reactivity with other steroid receptors ( PR , MR , AR , ER ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The enzymatic activities of glutathione s transferase ( GST ) , NAD ( P ) H : quinone oxidoreductase ( QR ) , aldehyde reductase ( AR ) , and glutathione reductase ( GR ) were measured by kinetics methods using UV Vis spectroscopy , and analyzed statistically by Student ' s t test . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
GAL 4 MRC ( E962A ) interacts weakly with the GR or AR N terminal domains in the presence of aldosterone . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The fact that certain ultraviolet ( UV ) filters used in cosmetics display estrogenic activity prompted us to study potential actions on androgen receptors ( AR ) in the human breast carcinoma cell line MDA kb 2 , which expresses functional endogenous AR and glucocorticoid receptors ( GR ) and is stably transfected with a luciferase reporter plasmid . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Transcriptional activation of the beta ( 1 ) AR is the result of cooperative binding between c myc and the glucocorticoid receptor on the beta ( 1 ) AR promoter . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
This protein , named ANT 1 ( AR N terminal domain transactivating protein 1 ) , enhanced the ligand independent autonomous AF 1 transactivation function of AR or glucocorticoid receptor but did not enhance that of estrogen receptor alpha . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
This regulation is specific for the AR , since the related glucocorticoid receptor is transcriptionally active at the G ( 1 ) / S boundary . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Genotypes for CYP 21 , HSD3B2 , G972R variant of IRS 1 , N363S variant of GRL , W64R variant of ADRB 3 , CAG repeat in exon 1 of AR , MspAI polymorphism in CYP 17 , and R264C variant of CYP19 . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Luciferase assays demonstrated that SRAP enhances the transactivation activity of the AR , the glucocorticoid receptor and the peroxisome proliferator activated receptor gamma ( 1 ) in a ligand dependent manner . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Transient transfection assays revealed that p 44 enhances AR , glucocorticoid receptor , and progesterone receptor dependent transcription but not estrogen receptor or thyroid hormone receptor dependent transcription . p 44 was recruited onto the promoter of the prostate specific antigen gene in the presence of the androgen in LNCaP cells . p 44 exists as a multiprotein complex in the nuclei of HeLa cells . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
ARA67 / PAT1 functions as a repressor with better suppressive effects on AR compared to glucocorticoid receptor and estrogen receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Compared with the glucocorticoid receptor , the DNA binding domain dimer interface of the AR has additional interactions that stabilize the AR dimer and increase the affinity for nonconsensus response elements . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In this study , we tested and compared the endocrine disruption activities of compounds in materials used to package foods ( bisphenol A , bisphenol F , and bisphenol A diglycidylether BADGE ) with natural molecules ( genistein , apigenin , kaempferol , and tangeretin ) in the human breast cancer cell lines MCF 7 ( ER ( + ) ) and MDA MB 453 ( AR ( + ) ; GR ( + ) ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The amino acid sequence of the VDR shows a significant homology with other members of the nuclear hormone receptor superfamily , including receptors for glucocorticoids ( GR ) , oestrogen ( ER ) , androgen ( AR ) , progesteron ( PR ) , thyroid hormone ( T3R ) , retinoic acid ( RAR ) , retinoid 10 ( RXR ) and over 150 orphan receptors . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Conversely , experiments in cell culture systems demonstrated significant antagonism of cortisol induced transcriptional activation by oxandrolone in cells expressing both the AR and GR . ^^^ Furthermore , the AR antagonists 2 hydroxyflutamide and DDE also repressed GR transactivation in an AR dependent manner . ^^^ A mutant AR lacking a functional nuclear localization signal ( AR ( 4RKM ) ) was active in oxandrolone mediated repression of GR even though oxandrolone bound AR ( 4RKM ) failed to enter the nucleus and did not affect nuclear import of GR . ^^^ These data indicate a novel action of oxandrolone to suppress glucocorticoid action via crosstalk between AR and GR . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Both ( E ) and ( Z ) GS also displayed high affinity for other steroid receptors , including the androgen ( AR ) , glucocorticoid ( GR ) , and progesterone receptors ( PR ) with Ki values ranging from 224 to 315 nM . ^^^ In cell based functional cotransfection assays , GSs behaved as antagonists of AR , GR , and MR , but as agonists of PR . ^^^ In addition , GS displayed activity in functional assays in cell lines expressing endogenous AR , GR , ER , and PR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Gel retardation experiments confirm the presence of active responsive elements for AR , estrogen receptor , glucocorticoid receptor and thyroid hormone receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In the following paragraphs non steroidal ligands which have full or partial agonistic activity will be described for the following receptors : PR , GR , AR , LXR and FXR . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
This review will focus on the cross regulation of AR and Wnt / beta catenin / Tcf but will also consider the dynamic manner in which RAR / RXR , GR , TR , VDR , ER , and PPAR modulate canonical Wnt signaling . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
SHP acts as transcriptional inhibitor of a large set of nuclear receptors , among which ER , AR , CAR , RXR , GR , LXR and ERRgamma . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
This coactivator , which contains multiple tetratricopeptide repeat ( TPR ) motifs from amino acid ( aa ) 294 , is identical to a component of U 5 small nuclear ribonucleoprotein particles and binds specifically to the AR or glucocorticoid receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The results showed that the apparent binding capacity ( Ro ) and the apparent dissociation constant ( Kd ) of GCR were 8468 + / 993 sites per cell and 10 . 2 + / 0 . 6 nM ( n = 6 ) , respectively , under unstressed condition . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The kainic acid induced decreases in hippocampal GR and MR binding were due to decreases in the maximum number of binding sites ( Bmax ) with no change in the apparent affinity ( KD ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
If a low concentration of the mixed agonist corticosterone ( 0 . 5 nM , close to the Kd for the MR ) was continuously perfused in vitro , 5HT responses were steadily depressed with a delay of 2 h , while high levels of corticosterone ( 5 nM , around Kd for GR ) only temporarily reduced 5HT responses . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Scatchard plot of the specific binding of 3H dexamethasone to the macrophages indicated that the Kd and Ro of glucocorticoid receptor was approximately 3 . 0 nM and 5 , 500 binding sites per cell , respectively . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Also 3 weeks post injection androgen and glucocorticoid receptor binding capacity ( Bmax ) and binding affinity ( Kd ) and the in vitro responsiveness of tumor cells to dihydrotestosterone and hydrocortisone were measured . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
On the other hand , sustained hypersecretion of corticosterone evoked by repeated stress significantly reduced the number of GR in rat liver cytosol without any change in Kd . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The affinity of glucocorticoid receptors ( Kd ) was strikingly decreased ( 9 . 36 + / 3 . 44 nM in group 1 ; 3 . 2 + / 1 . 5 nM in group 2 ; 2 . 0 + / 0 . 8 nM in controls ; P less than 0 . 01 ) . [ 3H ] Thymidine incorporation was decreased dose dependently by dexamethasone in controls and patients ; the effect was significantly blunted ( P less than 0 . 05 ) in group 1 patients , which suggests that activation of glucocorticoid receptor is impaired as a result of the glucocorticoid receptor abnormality . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : During a ten year period , a total of 1318 subjects were randomly selected on the basis of a process involving the community rosters in seven regions ( Cantons ) of Switzerland : ( Canton of Berne ; Canton of Zurich ; Western cantons ( GE , VD , NE ) ; Eastern cantons ( SG , AI , AR , TG , SH ) ; Southern cantons ( VS , GR , TI ) ; Central cantons ( LU , GL , ZG , UR , SZ , OW , NW ) and Northern cantons ( JU , FR , SO , AG , BL ) ) and encompassing all adult age groups ( 20 89 years ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
THG binds with high affinity but unselective to the androgen ( AR ) , progesterone ( PR ) , glucocorticoid ( GR ) and mineralocorticoid ( MR ) receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Further studies demonstrated that glucocorticoid receptor binding could be detected in the nucleus and cytoplasm , with a Kd of 5 10 10 ( 9 ) M . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
GR capacity was determined with [ 3H ] RU 28362 ( Kd = 0 . 39 nM , Bmax = 120 fmol / mg ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Due to its unique biochemical and biological characteristics , the 240 kD polypeptide is clearly a novel intermediate filament associated protein for which we have proposed the designation gyronemin ( Gr . gyros : around ; nemin : filament ) . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The glucocorticoid receptor number ranged from 6 . 2 10 10 ( 16 ) mole / microgram prot to 8 . 6 10 10 ( 16 ) mole / microgram prot , while the KD varied from 1 . 0 10 10 ( 8 ) M to 2 . 8 10 10 ( 8 ) M . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The recombinant proteins were found to bind steroids with the normal specificity for a glucocorticoid receptor but with reduced affinity ( Kd for triamcinolone acetonide approximately 70 nM ) . ^^^ However , synthesis of the corresponding fragments of glucocorticoid receptor in vitro using rabbit reticulocyte lystate resulted in the formation of proteins that bound triamcinolone acetonide with high affinity ( Kd 2nM ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The DNA binding domain of the GR ( 20 kD ) , expressed in bacteria , binds to the GRE as a monomer as well as a dimer and can form heterodimers with the native 94 kD GR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The rat liver glucocorticoid receptor also interacts with high affinity with 2G8 antiphosphotyrosine antibody coupled to Sepharose ( Kd value of 0 . 21 nM ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The maximal binding capacity ( Ro ) and dissociation constant ( Kd ) of glucocorticoid receptor ( GCR ) in peripheral leukocytes were estimated by radioligand binding method and the plasma cortisol levels measured in 25 stroke patients ( hemorrhagic 15 , ischemic 10 ) , compared with 12 healthy controls , the plasma cortisol level in stroke patients were significantly higher . ^^^ Ro of GCR in 15 hemorrhagic stroke , 10 ischemic stroke patients and 12 controls were 3496 + / 424 , 5678 + / 1101 and 5940 + / 763 sites / cell respectively kd of GCR were 10 . 47 + / 4 . 17 , 7 . 01 + / 3 . 24 and 5 . 81 + / 1 . 05 nmol / L respectively . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The number of specific [ 3H ] zacopride binding sites per milligram of protein was increased 6 fold in a 10 , 000 to 100 , 000 10 g membrane fraction as compared to the homogenate . [ 3H ] Zacopride bound to these membranes with high specificity ( greater than 90 % ) , exhibited high affinity for a homogeneous population of binding sites ( Kd = 0 . 3 nM ) and its binding was inhibited competitively by other 5 HT 3 compounds with the following rank order of potency : ICS 205 930 greater than GR 38032F greater than or equal to quipazine greater than BRL 24924 approximately MDL 72222 much greater than metoclopramide greater than 2 CH 3 5 HT 3 . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
A cell line derived from a human leiomyosarcoma , SK LMS 1 , has cystolic [ Bmax 201 . 6 + / 39 . 7 , means + / SD , fm / mg cytosol protein KD 14 . 6 + / 7 . 8 nM ( n = 8 ) ] and nuclear [ Bmax 189 . 2 + / 87 . 3 fM / mg DNA , KD 4 . 8 + / 0 . 26 nM ( n = 5 ) ] glucocorticoid receptor , by Scatchard analysis of tumors grown in male athymic mice . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The Kd of LAGS predicts that they can be half saturated by plasma corticosteroids in some physiological circumstances and , therefore , that they can play relevant roles in the rat liver . [ 3H ] dexamethasone was used as a ligand in exchange assays , to study the relative abundance of GR and LAGS in cell fractions of rat liver . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The type 2 glucocorticoid receptor of the spinal cord shows an affinity lower ( Kd 3 . 5 nM ) than that of the hippocampal type 2 site ( Kd 0 . 7 nM ) when incubated with [ 3H ] dexamethasone . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In wild type leukemia cells , the binding sites of cortivazol , those with both higher ( Kd approximately 5 10 10 ( 10 ) M ) and lower ( Kd approximately 1 10 10 ( 8 ] affinity appear to be on forms of the glucocorticoid receptor itself , and not on two different classes of molecules . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Scatchard analysis indicated that the 30 and 300 fM doses of hurIL 1 significantly decreased the Bmax ( maximum number of available binding sites ) , but did not alter the Kd ( affinity of the glucocorticoid receptor for ligand ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
GR cells contain a high affinity ( Kd approximately 10 ( 11 ) ) , low capacity receptor with a high specificity for 1 , 25 ( OH ) 2D3 . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We show that : In both cases , there is an actual competition of each antiglucocorticoid with the agonist dexamethasone for the same binding site ; the two Kd values derived from the two plots are almost identical for each antiglucocorticoid ; RU 486 can be distinguished from the three other antiglucocorticoids by its high biological efficacy and its high affinity for the glucocorticoid receptor in whole cells at 37 degrees C ( identical to its affinity in cytosol at 0 degree C ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The dissociation constant ( Kd ) was elevated and the Bmaxs of the GR in the cytosol were decreased by the lower concentration of Dex . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Thirty eight cancers ( 56 . 7 % ) had high affinity ( Kd less than 1 . 0 nM ) levels of GR . ^^^ Seven cancers ( 10 . 4 % ) had only low affinity GR ( Kd greater than 1 . 0 nM ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The glucocorticoid receptor capacity Ro and the dissociation constant Kd were determined in the liver of Xenopus laevis by Scatchard analysis . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In contrast , steroid binding with characteristics of the glucocorticoid receptor ( concentration of binding sites , 32 146 fmol / mg cytosol protein ; Kd , 1 . 7 3 . 1 10 10 ( 9 ) M ) was readily detectable in cytosol of all three adrenocortical carcinomas and all three pheochromocytomas examined . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The affinity of GR for CORT ( Kd , approximately 2 . 5 5 nM ) was 6 to 10 fold lower than that of CR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
However , the affinity ( Kd ) of the glucocorticoid receptor for dexamethasone was the same in both types of cells . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The rank order of potency of steroids to effect these changes ( betamethasone = dexamethasone greater than fludrocortisone greater than hydrocortisone = triamcinolone greater than aldosterone ) correlated with their glucocorticoid potency . [ 3H ] Dexamethasone binding to intact cells yielded a KD value of 3 . 47 + / 0 . 38 nM for binding to the glucocorticoid receptor which correlated well with the EC 50 for dexamethasone to alter beta adrenergic receptors . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
These inhibition values correlate well with the known Kd values for the high affinity type 1 B receptor ( 0 . 5 nM ) and for the lower affinity type 2 glucocorticoid receptor ( 2 . 5 5 nM ) , respectively , suggesting that ACTH secretion , CBG production , and thymus wet weight are regulated by the association of B with these receptor types . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
There were no differences in glucocorticoid receptor in lymphocytes from the two groups with regard to Kd and number of binding sites per cell . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
OVCA 433 cells contain about 14 , 000 nuclear glucocorticoid receptors ( GR ) per cell ( measured at 37 degrees C ) , with an average affinity ( Kd ) for [ 3H ] Dex of 6 . 6 10 10 ( 9 ) M . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The nucleotide sequence of the NGFI B gene was determined , and it encodes a 61 kd protein with strong homologies to members of the glucocorticoid receptor gene family . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Neutrophil elastase produces 52 kD and 30 kD glucocorticoid receptor fragments in the cytosol of human leukemia cells . ^^^ We recently found that formation of 52 and 30 kilodalton ( kD ) glucocorticoid receptor fragments in cytosol of leukemia cells is due to proteolysis and is blocked by diisopropylfluorophosphate ( DFP ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The molecular weight ( 93 kD ) as well as the isoelectric point ( 5 . 6 ) evaluated by these methods corresponded well to data reported for the classical glucocorticoid receptor in rat liver . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Lymphocytes were found to contain 2000 10000 glucocorticoid receptor sites / cell and the Kd value was in the range of 0 . 5 9 10 10 ( 9 ) M . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The patient ' s GR in whole cell assays had an increased dissociation constant ( Kd ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Two types of specific gastrin binding sites were found on tumor cell membranes of control mice , one with high binding affinity ( Kd = less than 1 . 0 nM ) and low capacity ( GR ) , and the other with a very high capacity and a low affinity ( Kd = greater than 0 . 1 microM ) ( type 2 gastrin binding sites ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Binding of [ 3H ] GR was of high affinity ( Kd = 0 . 2 nM ) and saturable . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In addition , it was found that CORT binds to CR ( KD approximately 0 . 5 nM ) with 5 10 fold higher affinity than to GR ( KD approximately 2 . 5 5 nM ) . . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The DEX stimulation appeared to involve glucocorticoid receptor function , since the concentration of DEX required for half maximal stimulation of aromatase activity ( 4 . 2 nM ) was similar to the dissociation constant ( Kd , 4 . 3 nM ) of the receptor ( for DEX ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Untreated CM S cells expressed a single class of high affinity ( KD = 4 . 5 + / 2 . 3 nM ) glucocorticoid receptor sites ( GCr ) ( 27 , 530 + / 3752 sites / cell ) as measured by a whole cell assay at 37 degrees C using [ 3H ] triamcinolone acetonide as tracer , while CM S cells induced to macrophage differentiation by 10 ( 7 ) M TPA showed reduced levels of GCr ( 10 , 729 + / 2135 sites / cell ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Stable interstrain differences in stress induced natural killer activity and glucocorticoid receptor binding ( Bm and Kd ) have been revealed . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Scatchard analysis of the binding of [ 3H ] triamcinolone acetonide to the glucocorticoid receptor showed a binding capacity of 170 fmol / mg protein and a dissociation constant ( KD ) of 1 . 76 10 10 ( 9 ) M . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Glucocorticoid receptor concentrations and dissociation constants ( Kd ) for [ 3H ] dexamethasone binding to lymphocytes from patients with rheumatoid arthritis , Sjgren ' s syndrome , and other connective tissue diseases did not differ significantly from values for normal volunteers . ^^^ Kd values correlated positively with glucocorticoid receptor concentrations after PHA stimulation both in normal volunteers and in patients with connective tissue diseases . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The kinetics of binding of dexamethasone reveal a saturable binding site [ dissociation constant ( Kd ) , approximately 1 nM ] , and the binding site obeys a steroid specificity characteristic of a glucocorticoid receptor . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Cultured chromaffin cells were found to have a cytosolic , high affinity , saturable glucocorticoid binding protein with the steroid specificity of a classical glucocorticoid receptor and a Kd of approximately 1 nM . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
EGF binding is half maximal near 2 4 10 10 ( 9 ) M , a concentration equal to the Kd of dexamethasone for the glucocorticoid receptor in these cells . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
GR treatment reduced the concentration of cytosol mineralocorticoid receptors ( Bmax ) but did not affect the Kd . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The cytoplasmic glucocorticoid receptor of 10 . laevis liver has a high affinity for [ 3H ] dexamethasone ( Kd , 0 . 3 10 10 ( 8 ) M ) , and its binding specificity for a variety of steroids is similar to that found for mammalian glucocorticoid receptors . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
However , when an excess of RU 26988 was added to block the glucocorticoid receptor , a different straight line was produced by Scatchard ' s analysis with a Kd of 3 . 78 10 10 ( 10 ) M . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We show here that despite these differences , the glucocorticoid receptors of keloid cells do not differ from those of normal dermal fibroblasts in steroid specificity , dissociation constant ( Kd ) , total number of binding sites ( Bmax ) , or nuclear binding of glucocorticoid receptor complexes . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
When rat liver cytosol containing [ 3H ] dexamethasone glucocorticoid receptor complex is exposed to immobilized heparin ( Sepharose heparin ; Seph hep ) the steroid receptor complex binds to the substituted Sepharose avidly [ Kd = 3 . 5 ( + / 1 . 7 ) 10 10 ( 10 ) M ] , and 80 90 % of the receptor present is adsorbed to the solid phase after 40 min at 0 degree C . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Glucocorticoid receptor in the rat uterus . 3H Dexamethasone binding sites with a Kd of approximately 0 . 7 nM and a maximum number of binding sites of approximately 0 . 3 pmoles / mg protein were demonstrated in the uterine cytosol of adrenalectomized rats only if dithiothreitol was present in the incubation mixture and the simultaneous presence of molybdate further enhanced the binding in the cytosol . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
GR were present in T cells grown from each of 22 normal individuals ; the binding capacity ( mean = 3851 + / 2880 sites / cell ) and affinity ( Kd = 7 . 4 10 10 ( 9 ) ) were similar in rested cultured T cells ( CTC ) to those reported in peripheral blood T lymphocytes . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
There were no significant differences in parameters of whole cell GR among healthy controls , Cushing ' s disease ( n = 4 , R 0 = 131 , 225 + / 29 , 950 / cell , Kd = 3 . 1 + / 0 . 6 nM ) and Addison ' s disease ( n = 2 , R 0 = 131 , 600 + / 25 , 600 / cell , Kd = 3 . 2 + / 0 . 2 nM ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The mean equilibrium dissociation constant ( KD ) of the interaction of [ 3H ] dexamethasone with the GR was 1 . 2 10 10 ( 8 ) M . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Binding studies using [ 3H ] triamcinolone acetonide show that Swiss 3T3 cells contain a single class of glucocorticoid receptor of uniform affinity ( KD = 2 . 0 nM ) , and about 34 , 000 receptor sites per cell . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Homogenates prepared from a previously established cell line derived from rabbit cornea contain a macromolecule with many properties of a glucocorticoid receptor , namely high affinity ( KD = 6 10 10 ( 9 ) M ) and saturable capacity ( 135 femtomoles / mg protein ) for dexamethasone , extreme heat lability , and a pattern of competition similar to that found in other glucocorticoid target cells . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Glucocorticoid receptor sites in the leukemic hairy cells ranged from 5 , 710 to 11 , 400 sites / cell , and the mean dissociation constant ( KD ) between the receptor sites and [ 3H ] dexamethasone was 0 . 67 + / 0 . 03 10 10 ( 8 ) M . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Scatchard analysis of GR hormone binding function was performed , with FK 506 treatment of cytosols causing Kd values to decrease ( 3 . 36 nM ) as compared to vehicle ( 8 . 42 nM ) and no addition ( 9 . 82 nM ) controls . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
LLC PK 1 cells expressed low levels of MR ( 13 . 9 fmol / mg protein , dissociation constant ( Kd ) 0 . 3 10 10 ( 9 ) M for aldosterone ) and glucocorticoid receptors ( GR ; 18 . 5 fmol / mg protein , Kd 0 . 3 10 10 ( 9 ) M for dexamethasone ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
It has an absolute affinity ( KD ) of 0 . 5 nM for the glucocorticoid receptor and a relative receptor affinity 1 . 5 and 3 . 0 times greater than that of beclomethasone 17 monopropionate ( 17 BMP ) and budesonide , respectively . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Furthermore , the dissociation constant ( Kd ) of the glucocorticoid receptor in 105 d fetal preadipocytes was numerically smaller than the Kd of receptors derived from other age groups , although only significantly lower than that of the 75 d group ( P < . 05 ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Concentrations in the range of the glucocorticoid receptor Kd ( 3 nM ) increased peptide content , whereas higher concentrations ( 30 and 300 nM ) decreased IR GRF content in cells and media . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
A diminished GCR binding affinity at baseline was noted with an elevated median dissociation constant ( Kd ) of 29 . 0 nM ( interquartile range at the 25th and 75th percentile [ IQ ] of 22 . 3 and 44 . 5 nM ) compared with normal controls ( Kd 8 . 0 nM [ IQ 7 . 0 , 9 . 2 ] ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The GR Bmax , Kd and PLA 2 of actisis control group were 61 . 48 + / 27 . 60 ( fmol / mg pro . ) , 13 . 11 + / 2 . 88 ( nmol / L ) , 81 . 06 + / 15 . 97 ( U ) . ^^^ The GR Bmax and Kd of asthmatic animals decreased significantly since the 3rd day , but the PLA 2 activity increased significantly since the 1st day as compared to the control group ( P < 0 . 01 ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
No significant differences in the GR level , or in its Kd and activation , were observed among rats of 1 , 3 , and 12 months of age . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
LPS treatment increased the Kd of [ 3H ] aldosterone of the hippocampal MR 4 . 3 fold and the apparent maximum binding capacity ( Bmax ) of [ 3H ] aldosterone by 65 % during a time interval when the concentration of corticosterone , the endogenous ligand of both hippocampal MR and GR , was elevated in the intact rat . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Using both immunocytochemistry and binding studies with ( 3H ) dexamethasone , we localized GR in the nuclei of IL cells and showed the presence of saturable and high affinity type 2 receptor sites , with Kd approximately 3 . 9 nM . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Long term treatment with desipramine significantly increased the Bmax of GR at both 2 ( increase by 42 % ) and 72 h ( increase by 27 % ) after its last dose , but did not change the Bmax of MR and the Kd of GR and MR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Bmax and Kd values of glucagon receptors ( GR ) , measured by [ 125I ] glucagon binding to liver plasma membranes , remained unchanged following partial hepatectomy . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Using a monospecific polyclonal antibody against the rat glucocorticoid receptor in Western blot analyses we found significant expression of the 94 kD receptor protein in an enriched pancreatic acinar cell preparation . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We demonstrated that these cell lines possess GR that bind the synthetic glucocorticoid , dexamethasone , in vitro with high affinity ( Kd = 2 3 nM ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The equilibrium dissociation constants ( Kd ) for dexamethasone binding to the glucocorticoid receptor ranged from 2 . 8 12 . 5 nmol / L and were positively correlated with dexamethasone IC 50 values for lysozyme synthesis ( r = 0 . 57 ; P = 0 . 002 ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We have now identified the glucocorticoid receptor ( GR ) in the SCLC cell line COR L 24 using a whole cell ligand binding assay ( Kd = 5 . 7 nM ; Bmax = 11 fmol / million cells ) , while another cell line , DMS 79 , lacked significant glucocorticoid binding . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Omental adipose tissue contained 4 times the number of GR as sc abdominal adipose tissue ( 42 . 0 + / 4 . 1 vs . 10 . 5 + / 2 . 3 fmol / mg protein , respectively ; P < 0 . 001 ) with similar Kd values . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The L 2 cell glucocorticoid receptor exhibited specific binding of [ 3H ] TA which was saturable and appeared to be a single species of binding sites with an apparent KD = 4 . 9 + / 3 . 7 nM and Bmax = 395 . 4 + / 84 . 4 fmol / mg protein . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The study of the glucocorticoid [ 3H ] dexamethasone specific binding ( glucocorticoid receptors , GcR ) to the cells showed reduced number of binding sites ( 8 10 10 ( 3 ) vs 120 10 10 ( 3 ) binding sites / cell ) and reduced Kd value ( 5 . 6 + / 0 . 7 vs 10 . 1 + / 2 . 1 nM ) in FH fibroblasts when compared with normal fibroblasts . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
No differences in the GR binding parameters ( BMAX and Kd ) , receptor form and level , or ligand GR complex binding to glucocorticoid response element ( GR GRE ) were detected , leading us to conclude that H 2 associated factors do not regulate the relative intrauterine responses to CORT by modulating the adult GR . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The effects of long term ( 28 days ) and short term ( 2 days ) administration of imipramine or amitriptyline ( 10 mg / kg p . o . , twice daily ) on the density ( Bmax ) and affinity ( Kd ) of mineralocorticoid ( MR ) and glucocorticoid receptors ( GR ) were determined in the rat hippocampus . ^^^ Long term treatment with antidepressant drugs significantly increased the Bmax of GR ( by 22 45 % ; both 2 and 72 h after their last dose ) , but did not modify the Bmax of MR and the Kd of GR and MR . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
A [ 3H ] dexamethasone radioligand binding assay was used to measure the number of glucocorticoid receptors ( GR ) and dissociation constant ( Kd ) in PBMC from normal donors and patients with SR asthma , cultured in the absence and presence of these cytokines . ^^^ PBMC from normal donors incubated for 48 h in the presence of combination IL 2 + IL 4 had nuclear GR with significantly reduced binding affinity ( GR Kd = 36 . 1 + / 1 . 63 nM , mean + / SEM ; p = 0 . 0001 ) as compared with PBMC incubated with medium alone ( GR Kd = 6 . 74 + / 0 . 46 nM ) . ^^^ The cytosolic GR Kd remained unchanged . ^^^ The IL 2 + IL 4 induced alteration in PBMC GR Kd was associated with an increase in GR number ( 8348 + / 964 vs 1710 + / 228 sites / cell ; p = 0 . 0003 ) . ^^^ Freshly isolated PBMC from four patients with SR asthma had a significantly reduced GR binding affinity ( Kd = 40 . 0 + / 2 . 68 nM ; p = 0 . 0001 ) when compared with seven normal subjects ( 7 . 15 + / 0 . 41 nM ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
There was no difference between Kd values of MR and GR binding in young and old dogs . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The results revealed high affinity ( Kd approximately 1 nM ) binding with a moderate capacity ( 42 . 9 + / 3 fmol / mg ) for 3H aldosterone ( with a 50 fold excess of cold RU 28362 ; mineralocorticoid receptor ) and high affinity ( Kd approximately 0 . 5 1 . 0 nM ) binding with higher capacity ( 183 . 2 + / 22 fmol / mg ) for 3H RU 28362 ( glucocorticoid receptor ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We have found that while the binding affinity ( Kd ) of MR and GR varies between tissues , there was no strain difference in any tissue . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
An open reading frame from yeast , which is highly homologous , encodes the previously uncharacterized 73 kD subunit of the yeast SWI / SNF complex required for transcriptional activation by the glucocorticoid receptor ( Cairns et al . , this issue ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In the current report , utilizing a [ 3H ] dexamethasone radioligand binding assay and Scatchard analysis , we found that IL 13 , a cytokine with similar actions as IL 4 , could induce diminished GCR binding affinity ( GCR Kd = 34 . 4 + / 2 . 3 nM with IL 13 vs Kd = 8 . 8 + / 0 . 7 nM for unstimulated control cells ; p < 0 . 001 ) in PBMC from normal subjects . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Bmax and Kd for GR showed a significant increase after 3 days and 1 week . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In addition , we also found good correlations between the Kd of several 5 HT 4 receptor ligands determined in cell membranes of mouse colliculi neurons and their Kd determined in previous studies in guinea pig striatum ( 0 . 95 ) and in human caudate ( 0 . 97 ) . [ 3H ] GR 113808 binding studies demonstrated that the 50 % decrease in 5 HT stimulated cAMP accumulation which followed a 5 min exposure period with 5 HT ( 10 microM ) was not accompanied by any significant decrease in the number of binding sites . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Lipopolysaccharide ( LPS ) and interleukin 1 beta ( IL 1 beta ) significantly increased the number of GR per cell ( median = 312 % and 171 % of control , respectively ; p < 0 . 05 ) , but significantly reduced the ligand affinity of these receptors , i . e . increased the Kd ( median = 410 % and 145 % of control , respectively ; p < 0 . 05 ) in BEAS 2B cells . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
A significant reduction ( p < 0 . 001 ) in the GCR binding affinity ( Kd ) was observed in ragweed allergic asthmatics during ragweed pollen season compared with PBMC obtained before and after ragweed season . ^^^ In vitro effects of allergen on PBMC GCR Kd were also examined by incubating PBMC from atopic asthmatics with allergen ( ragweed and cat ) versus Candida albicans . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We have shown that the apparent binding affinity of the glucocorticoid receptor in squirrel monkey lymphocytes is 5 fold lower than that in human lymphocytes ( apparent Kd , 20 . 9 + / 1 . 8 and 4 . 3 + / 0 . 2 nmol / L , respectively ; n = 3 ) , consistent with previous studies in mononuclear leukocytes isolated from the two species . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The limiting link in glucocorticoid and antiglucocorticoid realization are specific cytoplasmic glucocorticoid receptors ( GR ) which function is controlled by heat shock protein ( HSP ) of 90 kD molecular weight . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Binding experiments with [ 3H ] corticosterone demonstrated the presence of not only GR but also mineralocorticoid receptor ( MR ) : the dissociation constants ( Kd ) and the number of binding sites ( Bmax ) were 0 . 8 nM and 15 fmol / mg protein for MR and 5 . 0 nM and 73 fmol / mg protein for GR , respectively . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
This GR 125487 concentration is certainly sufficient to occupy all the 5 HT 4 brain receptors ( Kd = 10 ( 10 ) M ) but not to occupy 5 HT 3 receptors ( Kd > 10 ( 6 ) M ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Combined quantitative polymerase chain reaction ( PCR ) and cytosolic binding assay techniques are used to measure mineralocorticoid receptor ( MR ) and glucocorticoid receptor ( GR ) mRNA , Kd , and Bmax in various rat central nervous system ( CNS ) regions , namely amygdala , hypothalamus , hippocampus , cortex , pituitary , and cervical , thoracic , and lumbar spinal cord . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Immunoprecipitation experiments showed the GR antigen to be 110 120 kD Mr . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
No changes were found in the affinity ( Kd ) of the GR during infection , nor was there evidence of an infection associated decrease in plasma corticosteroid binding globulin . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We measured the number of glucocorticoid receptors ( GR ) in cord blood lymphocytes and the binding affinity ( Kd ) in 15 term and in 20 preterm babies . ^^^ The number of GR and the Kd were similar in the term and preterm ( with and without NRDS ) babies . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
There was no difference in the number of GR per cell among the three groups ( FMS : 6498 + / 252 , LBP : 6625 + / 284 , controls : 6576 + / 304 ) , but the dissociation constant ( Kd ) of the FMS ( 14 . 5 + / 0 . 9 nmol / l ) and LBP ( 14 . 7 + / 1 . 3 nmol / l ) subjects was significantly higher than that of the controls ( 10 . 9 + / 0 . 8 nmol / l ) ( p < . 05 ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
FP has an absolute affinity ( KD ) for the glucocorticoid receptor of 0 . 5 nmol / L and a relative receptor affinity 1 . 5 fold higher than beclomethasone 17 monopropionate ( 17 BMP ) and mometasone furoate , 3 fold higher than budesonide , and 20 fold higher than flunisolide and triamcinolone acetonide . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
METHODS : To evaluate the potential impact of inhaled fluticasone propionate on markers of airway inflammation [ GCR binding affinity ( Kd ) and eosinophil cationic protein ( ECP ) ] and oral GC requirements in steroid dependent asthmatics , we examined the effects of fluticasone propionate ( FP ) 500 microg or 1000 microg BID and placebo in a double blind , randomized study of 13 steroid dependent asthmatics at a single center . ^^^ Associated with the oral GC dose reduction on high dose FP therapy , were improvements in GCR binding affinity with the GCR Kd falling from 42 . 5 nM at baseline to 19 . 5 nM at 6 weeks ( P= . 08 ) . ^^^ The GCR KD values remained stable thereafter with values of 23 . 5 nM at 26 weeks ( P= . 02 ) and 19 . 5 nM at 52 weeks ( P= . 01 ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
We also studied in bronchial epithelial cells obtained by brushing from 13 untreated asthmatics , 18 steroid dependent asthmatics , 11 control volunteers , and 12 patients with chronic bronchitis , GR and heat shock protein 90 kD ( hsp 90 ) mRNA as well as the immunoreactivity of GR , intercellular adhesion molecule ( ICAM 1 ) , and granulocyte macrophage colony stimulating factor ( GM CSF ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The dissociation constants ( Kd ) for the high affinity glucocorticoid receptor of normal and oedematous udders are not significantly different , and nor are there differences between the total quantity of dexamethasone bound ( Bmax ) and mast cell density in normal and oedematous udders . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
RESULTS : The subjects with NA exhibited a significantly lower GR binding affinity at 4 am , detected by an elevated dissociation constant ( Kd ) of 22 . 2 + / 1 . 6 nmol / L compared with Kd at 4 pm ( 10 . 9 + / 0 . 7 nmol / L ; P = . 0001 ) . ^^^ The GR Kd of the NNA and control groups did not change significantly from 4 pm to 4 am . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
A significant reduction ( p < 0 . 001 ) in the GCR binding affinity ( Kd ) was observed in ragweed allergic asthmatics during ragweed pollen season compared with PBMC obtained before and after ragweed season . ^^^ In vitro effects of allergen on PBMC GCR Kd were also examined by incubating PBMC from atopic asthmatics with allergen ( ragweed and cat ) versus Candida albicans . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
GR binding parameters did not differ significantly between patients ( Kd 8 . 98 + / 1 . 07 nM , Bmax 183 + / 29 . 8 fmol / mg ) and controls ( Kd 9 . 36 + / 1 . 17 nM , Bmax 158 + / 16 fmol / mg ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Both preparations contained the novel 150 KD and the 94 KD classical GR peptides , suggesting that transcript 1A encodes both receptor forms . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
METHODS : A [ 3H ] dexamethasone radioligand binding assay was used to measure the number of glucocorticoid receptor sites ( R , given as number of sites per cell ) and glucocorticoid receptor binding affinity ( Kd , given in nM ) in peripheral blood mononuclear cells isolated from 26 healthy control blood donors and 27 patients with rheumatic diseases . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
In kidney and skin cytosol , [ 3H ] corticosterone binding was best fit with a model having a high affinity and a lower affinity site ; these sites are not consistent with the pharmacology of mammalian Type 1 ( MR ) and Type 2 ( GR ) receptors . [ 3H ] Corticosterone also bound to presumed CBG in plasma with high affinity ( Kd approximately 2 . 7 nM ) , but dexamethasone and androgens bound to plasma CBG with equivalently high affinity . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The aim of this study was to investigate the expression of GR and their apparent dissociation constant ( Kd ) in patients with IBD . ^^^ Expression of GR in IBD patients was suppressed to normal levels under steroid treatment ( 4 , 594 + / 2 , 237 ; p = 0 . 024 ) , but Kd remained elevated ( 13 . 56 + / 9 . 05 nmol / L ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The number of GCR sites per cell was analyzed with [ ( 3 ) H ] dexamethasone radioligand binding assay and binding affinity ( Kd given in nM ) in peripheral blood mononuclear cells isolated from 48 healthy children and 35 patients . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
RESULTS : Affinity ( Kd ) and number of GR was not different in PBMC of CFS patients when compared with the controls ( Kd , 12 . 9 + / 8 . 9 nmol vs 18 . 8 + / 16 . 2 nmol and GR number , 4 , 839 + / 2 , 824 / cell vs 4 , 906 + / 1 , 646 / cell ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Preparations containing GR , namely TJ 1 , TJ 9 and TJ 68 , significantly reduced the kd and increased the MDT of tolbutamide , while TJ 7 and TJ 40 had no effect on the early dissolution profile of tolbutamide . ^^^ The extent of decrease in the kd in the presence of TJ 1 , TJ 9 and TJ 68 was dependent on their GR contents . ^^^ In addition , GL , a major constituent of GR , induced a 50 % increase in MDT and a 30 % decrease in kd . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Average GR binding capacity and apparent dissociation constant ( Kd ) did not differ significantly between the obese and non obese groups . ^^^ There was no significant difference in average Kd between the groups nor was there a difference in the GR characteristics with respect to subjects ' age , plasma cortisol concentrations , or degree of adiposity . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
However , the physiological role of 11beta HSD 1 as prereceptor control device in regulating access of glucocorticoid hormones to the glucocorticoid receptor remains obscure in light of its low substrate affinities , which is in contrast to low glucocorticoid plasma levels and low Kd values of the receptors to cortisol . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The number of maximum binding sites ( Bmax ) and the dissociation constant ( Kd ) value of glucocorticoid receptor ( GR ) in Dunn OS cells were 19 , 560 sites / cell and 5 . 2 + / 0 . 8 nM , respectively . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The statistical difference of receptors per cell is significant between two groups ( p < 0 . 05 ) , patients with GIG having more GR binding sites , while the difference of Kd is not significant ( p > 0 . 05 ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
GR binding affinity ( Kd ) and receptor number ( n ) in peripheral blood monocytes ( PBM ) obtained from 10 normal subjects , 10 untreated , intermittent asthmatics and 10 severe asthmatics were assessed . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
RESULTS : Compared with the control group , after two weeks of high cholesterol feeding , increase of FV , FB , PV , PB and CC ( P < 0 . 05 ) , and decrease of GCR ( P < 0 . 01 ) and Bmax were found in cholesterol group , but with no significant change in Kd and CCK level . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The GR in Cushing patients had an increased Kd ( P < 0 . 05 ) preoperatively . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
Competitive binding revealed that MPA displays a higher relative binding affinity than NET A and progesterone ( prog ) for the human GR ( Kd of 4 . 2 nM for dexamethasone ( dex ) and Ki ' s of 10 . 8 , 270 and 215 nM for MPA , NET A and prog , respectively ) . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
The affinity of GR for DEX ( Kd = 11 . 2 + / 1 . 5 nM ) remained constant throughout the year while circulating CORT clearly increased during the reproductive season . ^^^
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10275 and P04150	Pubmed	SVM Score :0.0
NA