| Interacting proteins: P09429 and P04150 |
Pubmed |
SVM Score :0.0 |
| Cell lines lacking Hmg 1 grow normally , but the activation of gene expression by the glucocorticoid receptor ( GR , encoded by the gene Grl 1 ) is impaired . ^^^ |
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| Interacting proteins: P09429 and P04150 |
Pubmed |
SVM Score :0.0 |
| Using both stable and transient transfection assays , we demonstrate that the overexpression of high mobility group protein 1 C ( HMGI C ) , a Ras / ERK inducible HMG 1 family member , represses glucocorticoid receptor ( GR ) / dexamethasone ( Dex ) stimulated alpha ENaC / reporter activity in salivary epithelial cells . ^^^ A low level of ectopically expressed PIAS 3 cooperatively inhibits GR / Dex dependent alpha ENaC transcription in the presence of HMGI C . ^^^ Moreover , overexpression of antisense HMGI C construct is capable of reversing the repression mediated by Ras V 12 on GR and STAT 3 dependent transcriptional activation . ^^^ Together , our results demonstrate that Ras / ERK mediated induction of HMGI C is required to effectively repress GR / Dex stimulated transcription of alpha ENaC gene and STAT 3 mediated transactivation . ^^^ |
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| Interacting proteins: P09429 and P04150 |
Pubmed |
SVM Score :0.0 |
| We prove here that in living cells , the glucocorticoid receptor and HMGB 1 interact only within chromatin and not in the nucleoplasm and decrease each other ' s mobility . ^^^ GR and HMGB 1 interact only within chromatin and influence each other ' s residence time . ^^^ Thus , the formation of a GR HMGB 1 chromatin complex is more likely than one would expect from independent binding to chromatin of GR and HMGB 1 . ^^^ |
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| Interacting proteins: P09429 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09429 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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