| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :1.2109614 |
| When present simultaneously in the cell nucleus Fos and Jun were shown to form a specific and stable protein / protein complex with the glucocorticoid receptor . 1.2109614^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.65870445 |
| Interactions between the glucocorticoid receptor ( GR ) and c Jun / c Jun homodimer ( JUN ) on the promoter DNA of mouse mammary tumor virus long terminal repeat ( MMTV LTR ) are reported here using the electrophoretic mobility shift assay ( EMSA ) . 0.65870445^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :1.0101551 |
| Interactions between the glucocorticoid receptor and the AP 1 complex have been shown to regulate the transcription of some genes , including glucocorticoid receptor itself . 1.0101551^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.75560542 |
| In addition to direct , molecular interactions between AP 1 and glucocorticoid receptor ( GR ) , there is also evidence that the two signalling pathways may interact at different levels , but in vivo interactions of this nature have not been well characterized . 0.75560542^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.90781895 |
| Transcriptional activation of the u PAR gene involves PKC dependent mechanisms , and glucocorticoid suppression is probably due to interactions between the glucocorticoid receptor and another transcriptional activating system such as activator protein 1 ( AP 1 ) and / or nuclear factor kB ( NF kB ) . . 0.90781895^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.93953606 |
| To study this reduced DNA binding , we examined the ability of the nuclear translocated transcription factors activator protein 1 ( AP 1 ) , nuclear factor kappa B ( NF kappa B ) and cyclic AMP response element binding protein ( CREB ) to bind to their DNA binding sites and to interact with GR in PBMC from patients with steroid sensitive and steroid resistant asthma . 0.93953606^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :1.2841625 |
| These studies demonstrate that cross signaling between AP 1 and NF kappa B with GR may explain the anti inflammatory properties of glucocorticoids in airway epithelial cells . . 1.2841625^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.5753757 |
| In addition , although GR stimulated mitogen activated protein ( MAP ) kinase , p42 / 44 ( mapk ) , consistent with GR induced AP 1 promoter activation , GR induced melanogenesis was not blocked by PD 98059 , an MEK 1 inhibitor , suggesting that MAPkinase induced by GR does not have a direct effect on the level of melanin content . 0.5753757^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.50304968 |
| AP 1 competes with the GC / GR complex for the binding site on DNA . 0.50304968^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Recent evidence indicates that one aspect of steroid receptor action is an interaction with other trans acting factors , such as the glucocorticoid receptor with the AP 1 transcription factor , for example . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Although in vitro synthesized glucocorticoid receptor can disturb the DNA binding of Jun homodimers , it does not interfere with the binding of Fos Jun heterodimers or of purified AP 1 in vitro . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The basic region of AP 1 specifies glucocorticoid receptor activity at a composite response element . ^^^ For example , AP 1 and glucocorticoid receptor bind and mutually affect their activities at a 25 bp composite element , plfG . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Potential binding sites for AP 1 and glucocorticoid receptor were identified upstream of the putative TATA box . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Overexpression of Fos and Jun from transiently transfected constructs resulted in a functional inhibition of the glucocorticoid receptor in these mouse mammary epithelial cells . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The 18 bp region contains possible binding sites for AP 1 and helix loop helix transcription factors as well as a glucocorticoid receptor half site . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Although it is not excluded , that also in the case of overlapping DNA binding elements protein protein interaction might in fact be responsible for repression instead of substitution , the two situations can be clearly distinguished by specific mutants in the glucocorticoid receptor and in Jun and Fos . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| In epithelial cells , one E 2 dimer could not cooperate with the AP 1 complex , the glucocorticoid receptor , or the NF1 / K factor , whereas several E 2 dimers could . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Regulation of alpha fetoprotein gene expression by antagonism between AP 1 and the glucocorticoid receptor at their overlapping binding site . ^^^ A 23 base pair DNA element containing the overlapping glucocorticoid responsive element and AP 1 sites can be positively regulated by glucocorticoid receptor in the absence of c jun / c fos products . ^^^ Thus , these data demonstrate that negative regulation of the AFP gene by glucocorticoid may be due to the interference of AP 1 activity by glucocorticoid receptor either by direct competition for DNA binding or via protein protein interaction . ^^^ AFP promoter activity induced by c jun / c fos can be repressed by cotransfected glucocorticoid receptor . ^^^ When plasmids expressing glucocorticoid receptor , c jun and c fos are cotransfected together , they repress each other . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoid receptor mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP 1 enhancer elements . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| This sequence , denoted a `` composite ' ' glucocorticoid response element ( GRE ) , was bound selectively in vitro both by the glucocorticoid receptor and by c Jun and c Fos , components of the phorbol ester activated AP 1 transcription factor . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Negative regulation is due to repression of AP 1 activity by the glucocorticoid receptor ( GCR ) . ^^^ Transcriptional interference between c Jun and the glucocorticoid receptor : mutual inhibition of DNA binding due to direct protein protein interaction . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Functional antagonism between oncoprotein c Jun and the glucocorticoid receptor . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| In addition , this region and the first intron contain numerous potential Sp 1 , GCF , CRE fos , GCN , AP 1 , AP 2 , UCE , and sequences similar to the glucocorticoid receptor binding site . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Furthermore , sequences similar to transcriptional enhancer elements such as the c fos serum responsive element and the consensus sequences for cAMP induction , activator protein 1 binding , and the glucocorticoid receptor binding are identified within the highly conserved 5 ' flanking regions of the genes from the two species . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The glucocorticoid receptor synergizes with Jun homodimers to activate AP 1 regulated promoters lacking GR binding sites . ^^^ Despite clear differences in their modes of activation and DNA binding specificities , a regulatory cross talk between AP 1 and SHR such as the glucocorticoid receptor ( GR ) , has been established . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| These results suggest that PPAR alpha and Jun interact and share inhibitory activities , similar to Jun and the glucocorticoid receptor . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| In the corresponding promoter regions of the various exons , possible response elements for the glucocorticoid receptor , as well as potential binding sites for the AP 1 , AP 2 , and NF kappa B transcription factors are found . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| In the upstream important sequences , there were the nearest sequences for AP 1 binding motif , AP 2 binding element , SP 1 binding sequence , cAMP response element , half site of glucocorticoid receptor ( GRE ) binding sequence , half site of thyroid hormor receptor ( TR ) or retinoic acid receptor ( RAR ) binding sequence and MTF 1 binding sequence . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoid and phorbol ester effects in 3T3 L 1 fibroblasts suggest multiple and previously undescribed mechanisms of glucocorticoid receptor AP 1 interaction . ^^^ These and additional observations suggest direct and gene specific effects of glucocorticoid receptor and AP 1 on the transcription of responsive genes , and for some of these genes the pattern of regulation is not accounted for by mechanisms described to date . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Taken together , these results suggest that unlike transactivation , transrepression of AP 1 activity by the nuclear glucocorticoid receptor is ligand independent . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The activation of the DNA MeTase promoter by Jun is inhibited in a ligand dependent manner by the glucocorticoid receptor . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Coordinate regulation of glucocorticoid receptor and c jun mRNA levels : evidence for cross talk between two signaling pathways ' at the transcriptional level . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| In this study , we show that an activation deficient glucocorticoid receptor mutant is as effective as the wild type receptor in repression of AP 1 activity , inhibition of interleukin 2 production , inhibition of c myc expression and induction of apoptosis . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Involvement of c Jun in the control of glucocorticoid receptor transcriptional activity during development of chicken retinal tissue . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The messenger RNAs encoding the immediate early genes of the leucine zipper family ( c fos , c jun , jun B ) , the Zinc finger family ( zif 268 ) , the glucocorticoid receptor family ( NGFI B ) and the interferon family ( PC 4 ) are increased within 2 h after the lesion and return to normal levels at 6 h . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Binding of the activated glucocorticoid receptor to c Jun or Fos is likely to contribute to the decreased AP 1 DNA binding activity following dexamethasone treatment . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP 1 . ^^^ We show here by point mutations in the DNA binding domain and by the choice of steroid ligands that repression of AP 1 activity and transactivation functions of the glucocorticoid receptor ( GR ) are separable entities . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Since previous studies have demonstrated that components of the AP 1 transcription factor can modulate glucocorticoid receptor activity in other systems , we examined the regulation of the proto oncogenes c fos and c jun in response to CRF . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The expression of human papillomavirus type 16 ( HPV 16 ) early genes , including E 6 and E 7 transforming genes , is regulated by several cellular factors binding to the noncoding region ( NCR ) , such as the glucocorticoid receptor , NF 1 , and AP 1 , all of which are positive regulators . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Cell specific bifunctional role of Jun oncogene family members on glucocorticoid receptor dependent transcription . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Moreover , our findings suggest that an interaction between AP 1 and glucocorticoid receptor also occurs in our model of dexamethasone mediated apoptosis . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The glucocorticoid receptor complex binds to a protein complex AP 1 ; consisting of the proteins c JUN and c FOS ) and prevents this complex from inducing activation of the procollagenase gene . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Fos is a preferential target of glucocorticoid receptor inhibition of AP 1 activity in vitro . ^^^ We have investigated the effect of the purified glucocorticoid receptor ( GR ) DNA binding domain ( GR residues 440 to 533 [ GR 440 533 ] ) on DNA binding and transcription activation by Fos Jun heterodimers and Jun homodimers . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| There may be an abnormal activation of AP 1 in steroid resistant asthma , and high concentrations of beta 2 agonists may induce a secondary resistance by an interaction between the transcription factor CREB and the glucocorticoid receptor . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| These data suggest that the activated glucocorticoid receptor prevents ( by a protein / protein interaction ) the binding of transcription factor NF kappa B , but not AP 1 , to the NOS 2 promoter , thereby inhibiting the induction of NOS 2 transcription . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Most of them do not carry a classical binding site for regulation by a glucocorticoid receptor , but have instead regulatory sequences for transcription factors such as AP 1 or NF kappa B . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| This enhancer contains multiple protein binding sites , including sites for ubiquitous factors ( NF 1 and AP 1 ) , the glucocorticoid receptor , and the hepatocyte enriched transcription factors hepatocyte nuclear factor 1 ( HNF 1 ) and C / EBP . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Coordinate regulation of glucocorticoid receptor and c jun gene expression is cell type specific and exhibits differential hormonal sensitivity for down and up regulation . ^^^ We have previously proposed a novel mechanism for the coupled regulation of glucocorticoid receptor ( GR ) and c jun transcription in triamcinolone acetonide ( TA ) treated AtT 20 cells . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Interaction of the Ubc 9 human homologue with c Jun and with the glucocorticoid receptor . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| These data demonstrate that CRF is a potent stimulus for corticotroph expression of c fos , jun B and fos B , and suggest that the subsequent increase in AP 1 may play a role in activation of gene expression and / or as a modulator of glucocorticoid receptor function . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Furthermore , this element is recognized by a factor in mouse fibroblast cell extracts that is distinct from the glucocorticoid receptor and from AP 1 , both of which have previously been shown to be able to bind to this site . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| In clone OEM Cl cells , which contain glucocorticoid receptor ( GR ) but are resistant to lysis by Dex , the basal , and even the fully induced , cJun levels are below the basal levels in OEM 07 and H 10 cells . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Since AP 1 and the glucocorticoid receptor have a central role in regulating cell proliferation and differentiation , we have studied AP 1 activity , stimulated by 100 ng / ml TPA in normal fetal rat calvarial cells and in transformed rat osteosarcoma cells ( ROS 17 / 2 . 8 ) . ^^^ Additionally , either the c Jun or glucocorticoid receptor could displace its counterpart from the GRE / TRE but not from consensus GRE and TRE oligonucleotides , indicating that the abrogation of AP 1 mediated gene suppression by glucocorticoids could involve competitive binding . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Mechanisms in interleukin 2 protection against glucocorticoid induced apoptosis : regulation of AP 1 and glucocorticoid receptor transcriptional activities . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| A 5 cells and A5GR , a stable A 5 transfectant containing excess copies of the glucocorticoid receptor ( GR ) gene , were examined for potential alterations in AP 1 that accompany the restoration of glucocorticoid dependent growth inhibition . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The involvement of the three different transcription factors glucocorticoid receptor ( GR ) , nur 77 , and activator protein 1 ( AP 1 ) in such a scenario is the focus of this review . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Further upstream an AP 1 site , overlapped by a steroid hormone response like sequence , mediates down regulation of BSP transcription induced by TPA that is abrogated by a complex interaction between Jun and the glucocorticoid receptor protein induced by dexamethasone . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The early molecular events of glucocorticoid induced apoptosis have been investigated by studying glucocorticoid receptor levels , as well as binding activities to GRE and AP 1 sequences , using nuclear extracts from dexamethasone ( Dex ) treated rat thymocytes . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Further , specific binding of glucocorticoid receptor protein to the GRE was observed ; binding could be competed out only by excess cold GRE and not by mutated HO 2 GRE , or AP 1 . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Here we report that overexpressed Bcl 2 relieves the glucocorticoid receptor mediated repressive function on the AP 1 activity and completely inhibits the activation of CPP 32 like cysteine proteases . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| We observed segments of strong homology among species , and identified consensus sequences for the binding of various transcription factors , including the glucocorticoid receptor , AP 1 , RXR and p 53 . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Inhibition of inflammatory response is primarily mediated via the glucocorticoid receptor and the two transcription factors , AP 1 and NF kappa B , which are of crucial importance for the expression of pro inflammatory cytokines and other genes involved in the inflammatory process . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The glucocorticoid receptor ( GR ) and c jun promoters both contain activator protein 1 ( AP 1 ) sites ( GR AP 1 site and c jun AP 1 site , respectively ) that vary from the consensus AP 1 site . ^^^ Occupancy and composition of proteins bound to the AP 1 sites in the glucocorticoid receptor and c jun promoters after glucocorticoid treatment and in different cell types . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Redox regulation of transcription factors has recently been demonstrated for AP 1 , NF kappaB , Sp 1 and glucocorticoid receptor in vitro and in vivo . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The glucocorticoid receptor and AP 1 are involved in a positive regulation of the muscle regulatory gene myf 5 in cultured myoblasts . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Antagonism of glucocorticoid receptor transcriptional activation by the c Jun N terminal kinase . ^^^ The mitogen activated protein kinases ERK ( extracellular signal regulated kinase ) , JNK ( c Jun N terminal kinase ) , and p 38 phosphorylate and activate transcription factors that promote proliferative and inflammatory responses , whereas glucocorticoid receptor ( GR ) activation inhibits cell growth and inflammation . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Taken together , we suggest that ursolic acid may induce the repression of matrix metalloproteinase 9 by stimulating the nuclear translocation of glucocorticoid receptor , and the translocated glucocorticoid receptor probably down modulating the trans activating function of AP 1 to 2 O tetradecanoylphorbol acetate responsible element of matrix metalloproteinase 9 promoter region . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoid receptor ( GR ) has been shown to suppress activator protein 1 ( AP 1 ) mediated transcription by several molecular mechanisms . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 regulation of corticotropin releasing factor ( CRF ) , glucocorticoid receptor , c fos and c jun messenger RNA in the NPLC KC cell line . ^^^ In this report , we have examined the effect of IL 1 ( beta form ) in the presence and absence of DEX on CRF mRNA ( mRNA ) expression as well as the expression of human glucocorticoid receptor ( GR ) mRNA and the mRNA of the proto oncogenes ( c jun and c fos ) that have been implicated in CRF regulation . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Regulation of the glucocorticoid receptor gene by the AP 1 transcription factor . ^^^ The glucocorticoid receptor ( GR ) is a ligand activated nuclear transcription factor , and AP 1 ( Fos / Jun or Jun / Jun ) is a transcription factor whose components are nuclear proteins encoded by c fos and c jun protooncogenes . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Transrepression of c jun gene expression by the glucocorticoid receptor requires both AP 1 sites in the c jun promoter . ^^^ Repression of the c jun gene is due to the transrepression activity of the glucocorticoid receptor ( GR ) , as determined using GR mutants lacking this activity . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| We examined the 500 bp upstream of exon 1 in all three H . burtoni genes and identified putative binding sites for glucocorticoid receptor , androgen receptor , and progesterone receptor , as well as the transcription factors Ap 1 and Sp 1 . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Unstimulated peripheral blood mononuclear cells ( PBMCs ) from corticosteroid resistant ( CR ) but not corticosteroid sensitive ( CS ) asthmatics demonstrate increased activating peptide 1 ( AP 1 ) and decreased glucocorticoid receptor ( GR ) DNA binding . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| In addition to cis acting DNA sequences that serve as binding sites for trans acting factors such as Sp 1 , AP 1 , AP 2 , AP 4 , and the glucocorticoid receptor , the hMTIIA promoter contains eight consensus metal response element sequences . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Furthermore , this mechanism appears to be specific for the RARs , since another potent inhibitor of AP 1 activity , the glucocorticoid receptor , does not affect AP 1 dimerization . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The cytoskeletal network controls c Jun expression and glucocorticoid receptor transcriptional activity in an antagonistic and cell type specific manner . ^^^ Depolymerization of the actin or microtubule network in cells of the intact retina mimics the effects of cell separation , repressing glutamine synthetase induction by a mechanism that involves induction of c Jun and inhibition of glucocorticoid receptor transcriptional activity . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoid receptor down regulates c Jun amino terminal kinases induced by tumor necrosis factor alpha in fetal rat hepatocyte primary cultures . ^^^ Glucocorticoid receptor ( GR ) can be precipitated with the fusion protein , GST c Jun ( 1 79 ) , bound to agarose beads . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Our research tested the hypothesis that elevated glucocorticoid hormone activates the glucocorticoid receptor ( GR ) and that this activated receptor interferes with the activator protein 1 ( AP 1 ) transcription factor . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Although all three compounds inhibited PMA induced AP 1 transcriptional activity in cell based reporter assay , these compounds exhibited differential effects in separate transcriptional reporter assays for NF kappaB and glucocorticoid receptor . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| We find that leptin induces c Jun expression and attenuates the transcriptional activity of the glucocorticoid receptor ( GR ) in granulosa cells . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| After 2 h of aldosterone treatment , fra 2 mRNA was upregulated by 130 % , whereas c myc , c jun , c fos , and glucocorticoid receptor mRNAs were downregulated by 23 43 % . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| After binding to the glucocorticoid receptor ( GR ) , they repress the synthesis of proinflammatory cytokines via inhibition of the transcription factors AP 1 and NF kappa B . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The c Jun protein inhibits the transcriptional activity of the glucocorticoid receptor and thus represses glutamine synthetase expression . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Increased AP 1 may sequester the glucocorticoid receptor to produce a CR state . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| This interaction appears to compromise transcription , since overexpressed hRARalpha , in the absence of RA , is able to repress the activity of several RNA polymerase 2 dependent activators , including AP 1 and the glucocorticoid receptor . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| We recently identified selective ligands of the glucocorticoid receptor that dissociate transactivation from activator protein 1 transrepression , and most importantly retain in vivo anti inflammatory activity . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| It has recently been reported that the glucocorticoid receptor inhibits activity of the AP 1 transcription factor by the ligand dependant binding of glucocorticoid receptor ( GR ) to the fos and jun components of AP 1 . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| In the present study , we sought to further localize and characterize glucocorticoid receptor ( GR ) and AP 1 interactions at a functionally defined negative glucocorticoid response element ( nGRE ) of the CRH promoter . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Estrogen responses at AP 1 sites require the integrity of the ERalpha AF 1 and AF 2 activation surfaces and the complementary surfaces on the p 160 coactivator GRIP 1 ( glucocorticoid receptor interacting protein 1 ) , the NID / AF 1 region , and NR boxes . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| These results strongly suggest that direct protein protein interaction between AP 1 and glucocorticoid receptor is not involved in the suppression of the CPS gene in JVS mice and that the AP 1 element is the cis element which is responsible for the suppression . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The DNA binding independent function of the glucocorticoid receptor mediates repression of AP 1 dependent genes in skin . ^^^ The glucocorticoid receptor ( GR ) mediates the biological effects of glucocorticoids ( GCs ) through activation or repression of gene expression , either by DNA binding or via interaction with other transcription factors , such as AP 1 . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Interaction of glucocorticoid receptor isoforms with transcription factors AP 1 and NF kappaB : lack of effect of glucocorticoid receptor beta . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoids inhibit cytokine induced transcription factors ( NFkB , AP 1 ) and cytokines enhance glucocorticoid receptor ( GR ) transcriptional activity , thus reciprocally fine tuning immunological control mechanisms . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Consistently with previous findings , a glucocorticoid receptor mutant ( GRdim ) , which is deficient in dimerization , DNA binding , and transactivation , but retains AP 1 transrepressing activity , was as efficient as wild type GR in mediating the same effects of dexamethasone on JNK in transfected Cos 7 cells . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoid receptor mediated suppression of activator protein 1 activation and matrix metalloproteinase expression after spinal cord injury . ^^^ RU 486 , a glucocorticoid receptor ( GR ) antagonist , reversed MP inhibition of AP 1 activation . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The immunosuppressive effects of glucocorticoids arise largely by inhibition of cytokine gene expression , which has been ascribed to interference between the glucocorticoid receptor and transcription factors such as AP 1 and NF kappa B as well as by competition for common coactivators . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| General GC responsiveness was not compromised , as evidenced by Dex mediated suppression of endogenous c Myc and cyclin D 3 , and induction of c Jun and the glucocorticoid receptor . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that glucocorticoid mediated inhibition of enhancer function involves glucocorticoid receptor ( GR ) binding to the NF AT / AP 1 sites . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The glucocorticoid receptor ( GR ) associated with col3A through protein protein interactions with AP 1 , regardless of AP 1 subunit composition , and repressed transcription . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Employing DNaseI protection and electrophoretic mobility shift assays ( EMSA ) , we now demonstrate that DNA transcription factor protein complexes are formed on the c fms first promoter at a composite regulatory element containing overlapping binding sites for AP 1 proteins , bHLH factors , and the glucocorticoid receptor ( GR ) . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Overexpression of the human glucocorticoid receptor alpha and beta isoforms inhibits AP 1 and NF kappaB activities hormone independently . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Mammalian cell culture studies have shown that several members of the nuclear receptor super family such as glucocorticoid receptor , retinoic acid receptor and thyroid hormone receptor can repress the activity of AP 1 proteins by a mechanism that does not require the nuclear receptor to bind to DNA directly , but that is otherwise poorly understood . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Nuclear export of glucocorticoid receptor is enhanced by c Jun N terminal kinase mediated phosphorylation . ^^^ The c Jun N terminal kinase ( JNK ) phosphorylates the glucocorticoid receptor ( GR ) and inhibits GR mediated transcription . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoid receptor antagonism of AP 1 activity by inhibition of MAPK family . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Antagonism of glucocorticoid receptor transactivity and cell growth inhibition by transforming growth factor beta through AP 1 mediated transcriptional repression . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The elements likely for nuclear receptors retinoic acid receptor , retinoic acid 10 receptor , hepatocyte nuclear factor 3 , glucocorticoid receptor , nuclear factor kappaB and activator protein 1 were also found . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Expression of c fos , rather than c jun or glucocorticoid receptor mRNA , correlates with decreased glucocorticoid response of peripheral blood mononuclear cells in asthma . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Receptor interacting protein 140 binds c Jun and inhibits estradiol induced activator protein 1 activity by reversing glucocorticoid receptor interacting protein 1 effect . ^^^ We have previously shown that induction is mediated by the direct interaction between c Jun and ERalpha , which stabilizes a multiprotein complex containing the coactivator GRIP 1 ( glucocorticoid receptor interacting protein 1 ) . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| These results suggest that AP 1 proteins and glucocorticoid receptor regulate transcription of the GnRH R promoter in a heterologous system . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Regardless of the AP 1 complex ' s composition , glucocorticoid receptor activation inhibits AP 1 and prevents apoptosis . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The interplay between the glucocorticoid receptor and nuclear factor kappaB or activator protein 1 : molecular mechanisms for gene repression . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Inhibition by dexamethasone of interleukin 13 production via glucocorticoid receptor mediated inhibition of c Jun phosphorylation . ^^^ In a cell free system , the phosphorylation of glutathione S transferase fused c Jun by recombinant JNK was not inhibited by dexamethasone but was inhibited by the addition of recombinant glucocorticoid receptor ( GR ) . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| In recent campaigns for safer analogs , compounds have been sought which differentiate functional repression of existing transcription factors such as AP 1 and NFkappaB from GR mediated transcriptional activation arising from binding at glucocorticoid receptor response elements ( GREs ) . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| We focus on the role of transcription factors such as nuclear factor kappa B , activator protein 1 , peroxisome proliferator activated receptor , vitamin D receptor and the glucocorticoid receptor that mediate pro and anti inflammatory effects and therefore represent direct or indirect targets for therapeutic intervention . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| A novel class of phenylpyrazole fused Wieland Miescher ketone derivatives are high affinity , receptor specific , selective modulators of glucocorticoid receptor ( GR ) mediated transcription in vitro , dissociating transactivation , AP 1 repression , and NF kappaB repression from each other . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoid receptor ( GR ) mediated transrepression of the transcription factors AP 1 and NF kappaB , responsible for most of the anti inflammatory effects of glucocorticoids , is initiated by the tethering of GR to the promoters of target genes . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| We investigated the antiproliferative mechanism by GCs in human embryonic kidney 293 cells with stably introduced glucocorticoid receptor ( GR ) mutants that discriminate between cross talk with nuclear factor ( kappa ) B ( NF ( kappa ) B ) and activator protein 1 signaling , transactivation and transrepression , and antiproliferative vs . non antiproliferative responses . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Inhibition of Jun N terminal kinase ( JNK ) enhances glucocorticoid receptor mediated function in mouse hippocampal HT 22 cells . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Identification of endogenous glucocorticoid repressed genes differentially regulated by a glucocorticoid receptor mutant able to separate between nuclear factor kappaB and activator protein 1 repression . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Studies are testing a hypothesis that hippocampal transcriptional mechanisms and gene expression profiles linked to activator protein 1 ( AP 1 ) and glucocorticoid receptor ( GR ) , mineralocorticoid receptor ( MR ) or cyclic AMP response element binding protein ( CREB ) families of transcription factors distinguish successful or unsuccessful aging and cognition . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Microtubule disarray in primary cultures of human hepatocytes inhibits transcriptional activity of the glucocorticoid receptor via activation of c jun N terminal kinase . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The major antiinflammatory effects of glucocorticoids appear to be due largely to interaction between the activated glucocorticoid receptor and transcription factors , notably nuclear factor kappaB ( NF kappaB ) and activator protein 1 , that mediate the expression of inflammatory genes . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoid exerts its anti inflammatory effect mainly through the suppression of both AP 1 and NF kappaB by its receptor , glucocorticoid receptor ( GR ) . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| These include activator protein 1 and nuclear factor kappa B , glucocorticoid receptor , and so on . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| They act through the glucocorticoid receptor ( GR ) , a ligand dependent transcription factor that binds to and represses activities of other DNA bound regulators , activator protein 1 and nuclear factor kappaB , utilizing a p 160 GRIP1 as a corepressor . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The glucocorticoid receptor ( GR ) , activator protein 1 ( AP 1 ) , nuclear factor kappa B ( NF kappaB ) and c jun N terminal kinase ( JNK ) regulate the above mentioned processes ; we therefore assessed their role in BD . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| However , the major anti inflammatory effects of glucocorticoids appear to be due largely to interaction between the activated glucocorticoid receptor and transcription factors , notably nuclear factor kappaB ( NF kappaB ) and activator protein 1 ( AP 1 ) , that mediate the expression of inflammatory genes . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Inhibition of glutamine synthetase induction occurs via a mechanism that involves elevation of c Jun protein accumulation and repression of glucocorticoid receptor transcriptional activity . ^^^ We postulate that the cytoskeletal dependent increase in c Jun accumulation is involved in cell contact control of both cell proliferation and transcriptional activity of the glucocorticoid receptor protein . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Several transcription factors have been implicated in the inflammatory process in asthma , including the glucocorticoid receptor ( GR ) , NFkappaB , Activator Protein 1 ( AP 1 ) , Nuclear Factor of Activated T cells ( NF AT ) , cyclic AMP Response Element Binding Protein and more recently , the CCAAT / Enhancer Binding Protein ( C / EBP ) , Peroxisome Proliferator activated Receptor ( PPAR ) and the bZIP transcription factor , Nrf 2 . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| We investigated the effect of c Fos and / or c Jun co expression on transcription activation by the progesterone ( PR ) , glucocorticoid ( GR ) or androgen ( AR ) receptors using three different reporter genes and four different cell lines . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| In addition , we demonstrate that GR is capable of inhibiting , in a hormone dependent fashion , Fos mediated transactivation of AP 1 dependent transcription . ^^^ We have mapped the domain of the GR which is required for repression of AP 1 dependent transcription , to the region of central DNA binding domain . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| A computer based search of this region of bovine CYP 17 for consensus sequences associated with binding of transcription factors ( i . e . , GR , PR , CREB / ATF , AP 1 , AP 2 , AP 3 , AP 4 , AP 5 , OTF , CTF / NF1 , SP 1 ) shows only the consensus CREB / ATF sequence TGACGT which is also found to be at approximately the same position in the human CYP 17 gene . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| FK 506 , not cyclosporin A , was demonstrated for the first time in vivo to enhance GR and a hypothesis is proposed that FK 506 might enhance GR and AP 1 signalings in a system reciprocally controlled by NO and H2O2 . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| LM2GR cells demonstrated similar activator protein 1 ( AP 1 ) activity but higher GR activity than LM 2 cells as determined by using AP 1 chloramphenicol acetyltransferase ( CAT ) and mouse mammary tumor virus CAT transient transfection assays , consistent with the higher level of GR mRNA in LM2GR cells . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Recent studies have demonstrated a marked reduction in the binding of GR to DNA ; this appears to be due to increased binding of GR to the transcription factor activator protein 1 ( AP 1 ) . ^^^ Secondary steroid resistance in asthma may arise in response to the release of cytokines that activate AP 1 and other transcription factors that bind directly to GR . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Several other transcription factors including NF IL 6 , AP 1 , AP 2 , GR , CREB , Oct 1 , and Sp 1 are not affected by IL 10 . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The interaction of the transcription factors , activator protein 1 ( AP 1 ) , nuclear factor kappa B ( NF kappa B ) , and cAMP responsive element binding protein ( CREB ) with DNA and glucocorticoid receptors ( GR ) was analyzed in human peripheral blood mononuclear cells by gel mobility shift assays . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| High levels of DEX treated extracts led to a relative repression of CRF induced AP 1 binding , suggesting that ligand activated GR may lower available AP 1 levels by direct protein : protein interaction . ^^^ These data suggest that in the corticotrope cell relatively high levels of activated GR may influence CRF induced AP 1 DNA binding via transient genomic actions on basal c jun and stimulated c fos and / or via direct protein : protein interactions . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| In particular , in the presence of members of the AP 1 family of regulatory factors , cJun and cFos , a composite response element , plfG , is GR specific . ^^^ Transcription from a plfG linked gene is stimulated by GR in the presence of cJun and repressed by GR in the presence of cJun and cFos . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Sequencing analysis of a 1 . 7 kb subfragment revealed that it contained the entire 5 ' untranslated region and 46 bp of the coding sequence of TS cDNA , an upstream canonical TATA box ( TATAAA ) , and several binding sites for transcription factors ( AP 1 , PEA 3 , PU . 1 , and GR ) , indicative of a promoter / first exon region of the TS gene . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The activities of GR and MR at plfG , a 25 base pair composite response element to which both the steroid receptors and transcription factor AP 1 can bind , are analyzed here . ^^^ Under conditions in which GR represses AP 1 stimulated transcription from plfG , MR was inactive . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Here we show that CaMKIV / Gr induces the transcription factor activation protein 1 ( AP 1 ) alone or in synergy with T cell mitogens and with the p21ras oncoprotein . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Because of the ability of the transcription factors for activator protein 1 to antagonize GR function , c jun and c fos mRNA levels were examined . ^^^ These results suggest that the transformed A 5 cells apparently contain functional GR but that the high level of c jun mRNA expression ( probably resulting from the activated Ki ras allele in these cells ) may antagonize their ability to respond to the growth inhibitory signaling of glucocorticoids . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| This domain is also required for GR repression of AP 1 . ^^^ Surprisingly , while both AP 1 and NF kappa B can be inhibited by activated GR , synergistic NF kappa B / AP 1 activity is largely unaffected . ^^^ These data suggest that NF kappa B , AP 1 , and GR interact in a complex regulatory network to modulate gene expression and that cross coupling of NF kappa B and GR plays an important role in glucocorticoid mediated repression of cytokine transcription . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| This increase might be related to the decline in GR activity since elevation of c Jun expression in the intact tissue inhibits the transcription activity of GR . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| It is well known that AP 1 and glucocorticoid receptors ( GR ) interact and suppress each other . ^^^ Thus , decreased AP 1 levels in chronically stressed animals may help enhance the negative feedback effects of GR and prevent hypersecretion of glucocorticoid , which is implicated in the pathogenesis of stress related diseases . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Characterization of nuclear protein binding ( AP 1 , GR , and STAT ) in the genetically obese ( fa / fa ) Zucker rat . ^^^ The objective of our studies reported herein was to compare constitutive binding activity of nuclear proteins ( AP 1 , GR , and STAT ) , that may be relevant to obesity related diseases in the obese ( fa / fa ) Zucker rat to lean ( Fa / ? ) littermates . ^^^ AP 1 , GR , and STAT liver nuclear protein binding activity was analyzed using the electrophoretic mobility shift assay ( EMSA ) . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| We have recently demonstrated that CR asthma is associated with decreased GR and increased AP 1 ( Fos ; Jun ) DNA binding in peripheral blood mononuclear cells as compared to corticosteroid sensitive asthma . ^^^ These results highlight the central role of the AP 1 / GR interactions in glucocorticoid action in CR asthma . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The ER / GR interaction was observed both in the presence of estradiol and tamoxifen , which has previously been shown to have estrogen like action at an AP 1 response element . ^^^ The ER / GR / AP 1 response element interaction was present , not only in a cell line originally derived from a uterine cervical adenocarcinoma ( HeLa ) , but also in a cell line derived from the hypothalamus ( GT 1 1 ) . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| In addition , we found that the steroid analog ZK 98299 known to induce GR transrepression of AP 1 had no inhibitory effect on RelA activity . ^^^ Furthermore , the results from the use of mineralocorticoid receptor and anti glucocorticoids suggest that the mechanisms for GR mediated repression of NF kappaB and AP 1 are different . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Previous studies have indicated that this repression is exerted in part through antagonism between the glucocorticoid receptors ( GR ) and the AP 1 family of transcription factors . ^^^ In vitro binding experiments as well as mutation analysis of GR suggest that the mechanism of GR antagonism of Nur 77 is very similar to that of the antagonism between GR and AP 1 . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The following studies utilized selective antisera for the transcriptional proteins , Fos and Jun , to examine whether these immediate early gene products are upregulated in response to the GR agonist , dexamethasone ( DEX ) . ^^^ These data show that discrete populations of preoptic / hypothalamic neurons express c fos and / or jun in response to GR activation . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Transcriptional repression functions of the wild type and chimeric receptors were measured using an activator protein 1 ( AP 1 ) transrepression assay and identified the GR HBD as a more potent transrepressor of AP 1 transcriptional activation than the AR HBD . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| In contrast , at certain `` composite GREs ' ' GR and AP 1 bind to nonconsensus sequences , and GR either activates or represses depending on the subunit composition of AP 1 . ^^^ To uncouple the contributions to regulatory behavior of binding sequences and binding element arrangements , we examined GR action at `` paired elements , ' ' combinations of a simple GRE and a consensus AP 1 site , separated by different distances . ^^^ We found that GR synergized with either c Jun or c Jun c Fos at paired elements with GRE AP 1 site separations of > / =26 base pairs . ^^^ In DNA binding studies , GR and AP 1 cooccupied the paired elements . ^^^ GR synergized with c Jun and repressed c Jun c Fos . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Depending on the type of lymphocytes , the mechanism of apoptosis induced by glucocorticoids fall roughly in two categories : induction of `` death genes ' ' by the activated GR ( 1 kappa B , c jun ) or repression of survival factors ( AP 1 , c Myc ) . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that RIP 140 antagonized all GR mediated responses tested , which included activation through classical GRE , the synergistic effects of glucocorticoids on AP 1 and Pbx1 / HOXB1 responsive elements , as well as gene repression through a negative GRE and cross talk with NF kappaB ( RelA ) . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| This may occur via direct binding of the GR to DNA ( transactivation ) or by inhibition of the activity of transcription factors such as AP 1 and NF kappaB ( transrepression ) . 2 . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The nuclear effects of RAP 46 and BAG 1L are specific since GR mediated inhibition of AP 1 activity was not affected . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Transrepression results from the inhibitory interaction between the GR and other transcription factors like AP 1 and NF kappa B . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| In addition , we have found that GR , independently from GREs , blocks the induction of keratin gene expression by AP 1 . ^^^ We conclude that GR suppresses keratin gene expression through two independent mechanisms : directly , through interactions of keratin nGREs with four GR monomers , as well as indirectly , by blocking the AP 1 induction of keratin gene expression . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Specifically , stress erythropoiesis was found to require the DNA binding dependent function of GR whereas the antitumor promoting activity of GR in skin is mediated by interaction with the transcription factor AP 1 . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Thus , the ability of the transcription factors AP 1 and NF kappaB to induce gene transcription is attenuated by GR . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| All of these factors ( GR , c Jun , OCT 1 ) have transcription activation domains , but STAT 3 is required for the observed transcriptional increase . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| To explore the role of transcription factors in the pathogenesis of MCNS and the therapeutic effects of glucocorticoids , we examined the DNA binding abilities of NF kappaB , AP 1 , and GR in peripheral blood mononuclear cells ( PBMC ) from 6 children with MCNS and 6 healthy controls by electrophoretic mobility shift assay ( EMSA ) . ^^^ There were strong correlations between urinary protein and the baseline DNA binding ability of NF kappaB or AP 1 , or GR . ^^^ These results suggested that the abnormal activation of NF kappaB and AP 1 and the reduction of GR DNA binding abilities may be involved in the pathogenesis of MCNS . ^^^ Inhibition of NF kappaB and AP 1 and enhancement of GR DNA binding abilities by DEX may form the molecular basis of the effects of glucocorticoids in MCNS . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| GR also antagonized the activity of transcription factors , including NF kappa B , NF AT , and AP 1 , through direct and indirect mechanisms . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| These involve interference with activation / transcription factors such as AP 1 and NF kappaB , as well as binding of the GC GR complex to specific DNA sequences , called glucocorticoid response element `` GRE , ' ' with ensuing CAM gene inhibition . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| We characterized functional interactions of GR and GRIP 1 in a repression complex where GR tethers to DNA bound activator protein 1 ( AP 1 ) , as at the human collagenase 3 gene , and tested whether the identified interactions were similar or different at other response elements . ^^^ At the AP 1 tethering GRE , we mapped the GRIP 1 corepressor activity to a domain distinct from the two known GRIP 1 activation domains ; it exhibited intrinsic GR independent repression potential when recruited to DNA via Gal 4 DNA binding domain . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| This defect does not appear to be due to a reduced expression of GR but may be associated with a failure of GR to translocate into the nucleus and / or a reduced ability to inhibit AP 1 actions . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| In particular , most immunosuppressive and anti inflammatory effects are exerted by an interaction of GR with the activating protein 1 ( AP 1 ) and nuclear factor kappaB ( NF kappaB ) families of transcription factors without DNA binding . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The binding activity of GRE activating protein 1 ( AP 1 ) site and cross competition analysis demonstrated specific pattern of expression during the ageing and DEX treatment , suggesting that GR modulates the activity of transcription factors AP 1 ( Fos / Jun proteins ) through protein protein interaction . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Several of the proteins interacting with GR also participate in other signal transduction pathways such as the AP 1 pathway and the nuclear factor kappaB pathway . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The present study shows that PELP 1 does indeed coactivate ER mediated transcription but also serves as a corepressor of other nuclear hormone receptors ( NR ) and non NR sequence specific transcription factors tested , including GR , Nur 77 , AP 1 , NF kappaB , and TCF / SRF . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| GC antagonism of AP 1 relies mainly on the transrepression function of the GC receptor ( GR ) and mediates essential physiological and pharmacological actions . ^^^ In this regard , chromatin immunoprecipitation assays show that GC induced GR JNK association correlates with an increase in the loading of inactive JNK on the AP 1 bound response elements of the c jun gene . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| MIAs activate c Jun N terminal kinase ( JNK ) , which phosphorylates and inactivates GR , whereas proinflammatory cytokines , such as IL 6 or IL1beta , induce AP 1 or NF kB activation , respectively , leading to GR inhibition . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| In the present study , we examined the effects of dexamethasone ( Dex ) and Hsp 90 inhibitors , alone and in combination , on the activation of GR and proinflammatory transcription factors such as nuclear factor kappaB ( NF kappaB ) and activator protein 1 ( AP 1 ) . ^^^ These results suggest that Hsp 90 inhibitor itself inhibits the activation of NF kappaB and AP 1 , however , impedes Dex induced inhibition of IL 1beta induction by attenuating Dex mediated activation of GR and inhibition of the proinflammatory transcription factors . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| The mitogen activated protein ( MAP ) kinases , p 38 and c Jun N terminal kinase ( JNK ) , are important mediators of target gene activation by TNF , and JNK activation was earlier shown to inhibit GR mediated transcriptional activation by direct phosphorylation of GR at Ser 246 . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the inhibitory effect of GR on both AP 1 and NF kappa B mediated gene activation was not affected by As . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| It is assumed that transrepression of transcription factors such as AP 1 and NF kappa B is the main mechanism by which glucocorticoids mediate their anti inflammatory activity , whereas the side effects of GCs are mainly mediated by GR DNA interaction either by activation or by negative regulation of gene expression . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| GR inhibition of many proinflammatory response genes occurs through induction of the synthesis of anti inflammatory proteins as well as through repression of proinflammatory transcription factors , such as nuclear factor kappaB ( NF kappaB ) or activator protein 1 ( AP 1 ) . ^^^ In this review , we discuss the molecular mechanisms underlying GR inhibition of inflammatory responses , with an emphasis on repression of NF kappaB and AP 1 and their respective signaling pathways . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Thus , our data suggest a mechanism for transrepression between two nuclear receptors , GR and NGFI B , that is unique , although quite similar to that proposed for transrepression between GR and activator protein 1 ( AP 1 ) or nuclear factor kappaB ( NFkappaB ) . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Here , we show that transcriptional repression of the Interleukin 5 gene involves recruitment of GR to a DNA region located within the IL 5 proximal promoter , which is bound by NF AT and AP 1 proteins . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Further functional analyses of the transcription factors suggested that SUMO 4 sumoylation represses AP 1 and AP 2alpha transcriptional activity , but enhances GR DNA binding capacity . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Down regulation of beta catenin by RNA interference impeded the expression of cyclin D 1 but not of c myc or c jun and had no significant effect on the proliferation of U2OS / GR cells . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Glucocorticoids activate glucocorticoid receptors ( GR ) , which act as transcription factors and inhibit transcription induced by NF kappaB and AP 1 . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| More than a decade ago our view of gene regulation by glucocorticoids ( GC ) and other steroid hormones underwent a dramatic change with the discovery of negative crosstalk ( transcriptional interference ) between the GC receptor ( GCR ) and transcription factor AP 1 ( Jun : Fos ) . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| Subsequent analysis of brain tissues revealed NBI 30775 induced increases in the nuclear translocation of glucocorticoid receptors ( GR ) and BAG 1 , an upregulation of mRNA transcripts encoding GR , mineralocorticoid receptors ( MR ) and CRH R 1 , and a suppression of the DNA binding activity of the transcription factor AP 1 . ^^^ Molecules such as GR , MR , BAG 1 and AP 1 have been identified as some of the drug ' s intracellular targets ; interestingly , changes in these molecules have also been seen in response to conventional antidepressants , showing that structurally and mechanistically unrelated anxiolytic and antidepressant drugs can influence common downstream pathways . . ^^^ |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|