| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| While signaling by either the TCR or glucocorticoid receptor ( GR ) can induce apoptosis in thymocytes , recent studies have shown that combining these signals results in survival of CD 4 ( + ) CD 8 ( + ) thymocytes . ^^^ |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| RU 486 , a glucocorticoid receptor antagonist , significantly abrogated apoptosis in CD 4 ( ) CD 8 ( ) , CD 4 ( + ) CD 8 ( + ) , and CD 4 ( ) CD 8 ( + ) subsets and also prevented loss in cell numbers . ^^^ |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| The expression of glucocorticoid receptor ( GCR ) in double negative ( DN ) , double positive ( DP ) and CD 4 or CD 8 single positive ( SP ) cell populations was assessed . ^^^ |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| Subsets of both human CD 4 and CD 8 T cells bound the GR antigen . ^^^ |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| MAIDS mice inoculated with CD 4 ( + ) T cells from GR treated mice were also resistant to C . albicans infection . ^^^ The susceptibility of normal mice inoculated with type 2 T cells was reversible by ( 1 ) administration of GR and ( 2 ) inoculation of CD 4 ( + ) T cells from GR treated mice and injection of a mixture of mAbs targeted against type 2 cytokines ( IL 4 and IL 10 ) . ^^^ Type 2 cytokines were not detected in sera of MAIDS mice inoculated with CD 4 ( + ) T cells from GR treated mice , while they were present in sera of MAIDS mice treated with saline . ^^^ These results suggest that , by inducing CD 4 ( + ) T cells which suppress type 2 cytokine production by MAIDS associated Th 2 cells , GR improves the resistance of MAIDS mice to C . albicans infection . . ^^^ |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| In the adult , GR is specifically induced to high levels in CD 25 ( + ) CD 4 ( ) CD 8 ( ) thymocytes and returns to basal levels in CD 4 ( + ) CD 8 ( + ) thymocytes of wild type and positively selecting female HY TCR transgenic mice , but not negatively selecting male HY TCR transgenic mice . ^^^ |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| Furthermore , reduced hepatic T cell GR expression in ANIT fed rats was associated with reduced hepatic CD 4 ( + ) T cell sensitivity to dexamethasone inhibitory effects ( that is , inhibition of interleukin 2 receptor expression ) . ^^^ |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| In group 4 , the average percentage of CD 3 ( 70 + / 4 % ) and CD 4 ( 44 + / 5 % ) were significantly higher than in those of Gr . 1 ( CD 3 = 51 + / 11 % , CD 4 = 30 + / 12 % ) , Gr . 2 ( CD 3 = 52 + / 7 % , CD 4 = 30 + / 8 % ) , and Gr . 3 ( CD 3 = 52 + / 9 % , CD 4 = 26 + / 8 % ) . ^^^ |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| T ; median CD 4 T lymph values were 27 % in gr . ^^^ |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| Similarly , mice expressing reduced GC receptor ( GR ) levels due to the presence of an antisense transgene have fewer CD 4 ( + ) CD 8 ( + ) thymocytes , which was due to an impaired transition from CD 4 ( ) CD 8 ( ) precursors and increased apoptosis . ^^^ Furthermore , whereas more CD 4 ( + ) T cells survived the selection process in mice expressing single peptide MHC class 2 complexes and reduced GR levels , these cells largely failed to recognize the same MHC molecules bound with foreign peptides . ^^^ |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04150 and P01730 |
Pubmed |
SVM Score :0.0 |
| NA |
|